CN105341906A

CN105341906A - Medical formula food for diabetes

Info

Publication number: CN105341906A
Application number: CN201510720206.6A
Authority: CN
Inventors: 马方; 陈伟; 刘鹏举; 何书励; 胡安然
Original assignee: Jing Shanmei Biotech Inc
Current assignee: Jing Shanmei Biotech Inc
Priority date: 2015-10-30
Filing date: 2015-10-30
Publication date: 2016-02-24

Abstract

The invention belongs to the technical field of medicinal and edible formulas and new resource foods, and particularly provides a medical formula food, a specific medical formula food or an unspecific formula food for patients suffering from diabetes. According to the requirements of the 'General Rules for Formula Foods for Special Medical Purposes', combining the constitution characteristics of the patients suffering from the diabetes, and reasonably mixing various 'medicinal and edible' traditional Chinese medicines according to the quintessence theory of traditional Chinese medicine science, the formula food is prepared by mixing extract essences extracted from medicinal and edible traditional Chinese medicines by adopting a half-bionic extraction method, various micro-capsulated probiotics, short chain polypeptides extracted through biological enzymolysis, prebiotics, amino acids, carbohydrate, grease with a health-care function, various vitamins and mineral substances and other technologies. The formula food not only can be used as a single nutrient source to meet the nutrient requirements of the patients suffering from the diabetes, but also has the efficacies of resisting ageing, strengthening the activity of insulin, reducing blood sugar, reducing blood lipid, reducing blood lipid, reducing weight and enhancing immunity.

Description

Diabetic medicine formula food

Technical field

The invention belongs to integration of drinking and medicinal herbs class formula and new resource food technical field, specifically the Traditional Chinese Medicine marrow of " Chinese medicine of integration of drinking and medicinal herbs " is theoretical and " multiple probio " combines, and adds with small peptide, prebiotics, amino acid, water-soluble dietary fiber, the medical science formula food preventing and treating diabetes, specific full nutritional formulas or the non-fully nutritional formulas that have the grease of health care, B B-complex, composite mineral matter to make for auxiliary material.

Background technology

The metabolic disease of diabetes to be one group with hyperglycaemia be feature, hyperglycaemia be then due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause, long-standing hyperglycaemia during diabetes, cause various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction, diabetes can cause multiple complications, if diabetes do not obtain enough control, some acute complicationses can be caused, as hypoglycemia, DKA, non-ketone hyperosmolar coma, serious long-term complications comprises: angiocardiopathy, chronic renal failure is (also known as diabetic nephropathy, the main cause of haemodialysis in developing country adult), PVR is (also known as diabetic eye diseases, can blinding, the principal disease of the non-aged adult's blinding of developing country), DPN and microangiopathies, wherein, microangiopathies may cause erectile dysfunction (impotence) and wound to be difficult to healing, the wound that foot is difficult to heal then may cause gangrene (being commonly called as " diabetes "), and then cause patient's amputation, if diabetes obtain enough control, and blood pressure fully to be controlled and in conjunction with good habits and customs (as non-smoking, the body weight etc. of keeping fit), then the danger suffering from above-mentioned complication can effectively reduced, World Health Organization's report of 2011 points out that the whole world has 3.46 hundred million people to suffer from diabetes, within 2004, estimate at 3,400,000 people and die from the consequence that hyperglycaemia causes, Diabetes Death more than 80% occurs in low income and middle income country, the origin cause of formation of diabetes roughly has following two kinds: 1. inherent causeall there is obvious genetic heterogeneity in 1 type or diabetes B, there is family's morbidity tendency in diabetes, 1/4 ~ 1/2 patient has Diabetes family history, have at least the genetic syndrome of more than 60 kinds can with diabetes clinically, type 1 diabetes has multiple DNA site to participate in morbidity, wherein close with DQ loci polymorphism relation in HLA antigen gene, multiple clear and definite gene mutation has been found at diabetes B, as insulin gene, insulin receptor gene, glucokinase gene, chondriogen etc. 2. environmental factorfeed too much, it is the topmost environmental factor of diabetes B that physical exertion reduces the obesity caused, the individuality with diabetes B genetic predisposition is easily fallen ill, and there is immune system abnormality in type 1 diabetes patient, in some virus as Coxsackie virus, rubella virus, parotid gland virus etc. cause autoimmune response after infecting, and destroy insulin β cell, " integration of drinking and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science, the traditional Chinese medical science is always emphasized " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet, allow people dispel slight illness in the process enjoying cuisines, avoid and have an injection, take medicine, even pain of surgery,

For food of special nutrients, there are corresponding regulation and Application and Development in the developed country such as the U.S., European Union; And the full nutritional formulas of wholefood clear stipulaties: 2.1.1 in China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 specific full nutritional formulas: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition;

Traditional Chinese medical science traditional medicine is thought: " spleen (i.e. digestive system) is the foundation of acquired constitution ", and stomach health is healthy basis, and 99% of human nutrition needs by intestinal absorption, and intestinal bowel disease is also the source of ten thousand diseases; But along with the age is larger, in enteron aisle, profitable strain (probio) ratio reduces gradually; As Bifidobacterium accounts for 98% infant period, be down to 10% to during the middle age, within 65 years old, only account for 5% later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies display, normal flora human consumption, immunity and disease-resistant etc. in have many irreplaceable effects; The change of gut flora composition and the generation of various diseases, particularly intestines problem develop closely related, and find from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is that one intervenes control method safely and effectively;

Contacting of intestinal microecology system and diabetes: type II diabetes (type2diabetes, T2D) be a kind of complicated endocrine system disease jointly caused by h and E factor, prolonged illness can cause multiple system damage, be in a bad way or stress time can there is the acute metablize confusion, as DKA etc., its cause of disease and pathogenesis more complicated, think genus polygenes at present, multifactorial different substantiality disease, human body intestinal canal microorganism plays significant role to maintenance human health, and in enteron aisle, remain dynamic balance, and this balance is when causing gut flora to get muddled because some factor is broken, human body may will suffer from various disease, research discloses: the intestinal microflora imbalance of moderate has only appearred in patients with NIDDM, further functional analysis shows, lost some beneficial bacteriums in patients with NIDDM enteron aisle, some harmful bacterias increase to some extent on the contrary, such as, produce butyric acid bacteria to reduce to some extent in patients with NIDDM, and butyric acid Principal tunable joint human body intestinal canal microecological balance, critical effect is played to intestinal health, simultaneously, in some conditioned pathogen increased Chinese colonies in this research, there is very much higher sample, in addition, microbial gene functional analysis also shows that the oxidative pressure etc. of intestinal environment may exist certain relation with diabetes indirectly,

Though direct probiotic oral has certain effect, but due to probio cannot field planting in enteron aisle, and stop, occupy-place is little, easily run off, withdraw rear harmful bacteria and easily recur, associated patient needs long-term taking, and treatment cycle is long, often uses afterwards that recurrence rate is very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by the key technology research to probio field planting mechanism in enteron aisle over nearly 3 years, make great efforts " Chinese medicine of the integration of drinking and medicinal herbs " compound seeking to improve probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can play field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity etc. of raising probiotic cell, based on above-mentioned key element, suitable food materials screen from tens of kinds " Chinese medicines of integration of drinking and medicinal herbs " in this seminar, Late Cambrian interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and jerusalem artichoke and stachyose, yeast, after Glu etc., very strong field planting effect is had to external source probio, prescription for probio in enteral microecological formulation is selected to provide experimental basis,

Favourable is in the market primary raw material in order to eat source property small peptide, add the corn stigma of medicine-food two-purpose, sealwort, lily, the extract of the root of kudzu vine, B B-complex and mineral matter, composition compound prescription, utilize the product that probio is primary raw material in addition, but also do not find the constitutive character in conjunction with diabetic, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility is with the Chinese medical extract elite of more than ten kinds medicine-food two-purposes, multiple probio, prebiotics is primary raw material, with small peptide, amino acid, there is the grease of health care, water-soluble dietary fiber, B B-complex, the medical science formula food that composite mineral matter auxiliary material is made, specific full nutritional formulas or similar products.

goal of the invention

The object of the invention is on the theoretical treatment method of succession traditional Chinese medical science marrow, the initiative extract by the probio of the intestinal microecology of the multiple diabetic of improvement and " Chinese medicine of integration of drinking and medicinal herbs " compound combines, add with small peptide, amino acid, carbohydrate, there is the grease of health care, multivitamin, several mineral materials is auxiliary material, the hyperlipemic patients institute essential nutrients of hypoimmunity can not only be supplemented, improve body nutrition condition, can also and utilize function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the medical science formula food of the acceptable applicable patients with diabetes mellitus of people, certain medical formula food or nonspecific medical science formula food.

Summary of the invention

This R&D team is according to the requirement of " special medicine purposes formula food general rule ", in conjunction with the constitutive character of diabetic, the advanced physiology of comprehensive nowadays American Harvard University, medicine, the achievement in research such as nutrition and clinical practice, according to " the middle residence that disappears benefit ", marrow theory (the liver of the Traditional Chinese Medicine of " equilibrium is taken good care of ", spleen, kidney three is dirty with being adjusted to main principle), adopt Chinese medical extract elite and the new resource food of more than three kinds or whole medicine-food two-purposes, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, there is the grease of health care, amino acid, multivitamin and mineral matter auxiliary material, not only can be used as the nutritional need of the full hyperglycemic patients of single source of nutrition, strengthen insulin active in addition, hypoglycemic, reducing blood lipid, the medical science formula food of effect of lowering blood-fat and reducing weight and develop immunitypty, certain medical formula food or nonspecific medical science formula food (compound prescription be combined into),

The main component of the present invention's formula is:

1. Chinese medical extract is dirty with being adjusted to main principle from the liver,spleen,kidney three theory of traditional Chinese medical science according to the constitutive character of diabetic, utilize the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to prevent and treat diabetes, and choose following several large class medicine and carry out compatibility; Wherein: Cr-enriched yeast strengthens insulin active, control blood sugar, fatty storage capacity can be regulated, help loss of weight, reduce the content of blood cholesterol and triglycerides, prevention cardiovascular disease, the calorific value of stevioside is only 1/300 of sucrose, do not absorbed after taking in human body, not producing heat, is the sweetener that diabetes and bariatric patients are suitable for; The fermentation preparation of corn stigma has the reduction blood sugar effect of highly significant; Sealwort has and improves immunity of organisms, hypoglycemic, reducing blood lipid, the effect such as antibacterial, antiviral, antitumor; Puerarin has hypoglycemic, expansion peripheral vascular, the particularly effect such as coronary artery dilator blood vessel, Antiaggregating activity on platelet, thus be provided with treatment diabetes, and the effect of the peripheral nerve injury improved caused by its microangiopathies and PVR and renal function pathology; There is the protein similar with insulin in seed of bitter gourd, have and fall hypoglycemic effect;

Medicinal and edible Chinese medicine extract of the present invention and new resource food refer to: Cordyceps sinensis, the stem of noble dendrobium, lucidum spore powder, glossy ganoderma, the Radix Astragali, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, Ligusticum wallichii, motherwort, the red sage root, the dried rhizome of rehmannia, cultivated land, the wind-weed, the root of straight ladybell, the tuber of dwarf lilyturf, rhizoma alismatis, the banksia rose, Cordyceps militaris, line leaf broom top, ampelopsis grossdentata leaf, Euglena, Qingqian Willow leaf, haematococcus pluvialis, Camellia nitidissima, the luxuriant isapgol husk of circle, tealeaves theanine, phoenix peony, Guangdong Cordyceps militaris, corn stigma, sealwort, lily, the root of kudzu vine, balsam pear, cassia seed, Chinese mesona herb, it shellfish ,sessileflower Acanthopanax Bark, dark plum, Radix Glycyrrhizae, barley seedling, hawthorn, roselle, Chinese yam, semen litchi, konjaku, sea-buckthorn, chlorella pyrenoidosa, currant lobate layer bacterium fermentation mycelium, Saussurea involucrata culture, first milk basic protein, Cr-enriched yeast powder, steviol glycoside, dragon protein, black fungus more than three kinds or whole mixtures wherein,

2. many kinds of probios: make probio major part can arrive enteron aisle by the strong acid environment of stomach, to promote the propagation of probio, regulate microecological balance in intestines, promote the absorption to trace element, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, obviously can reduce the level of intestinal endotoxemia and the generation of preventing liver injury; Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, has research application enteron aisle not absorb rifamycin antibiotic former times bright (rifaximin), by urease-producing in suppression enteron aisle and the growth of producing ammonium bacteria, prevents and treats the generation of diabetes;

Multiple probio of the present invention all adopts the probio after microencapsulation, and the probio described in it is that Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici are wherein a kind of, several or all mix; Wherein Bifidobacterium refers to that bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis) are wherein a kind of, several or all mix; Lactobacillus refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii subspecies, lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri are wherein a kind of, several or all mix;

3. small peptide: be oligopeptide, refer to the small molecule protein utilizing bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is at below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need directly to absorb through digestion, bioavailability is high, absorbing and utilizing the amino acid and complete protein that are better than dissociating, can be applicable in Protein intake food, especially for the crowd that abilities of digestive and absorption is low, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function improving small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,

Small peptide of the present invention refers to that marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix;

2, prebiotics: with short probio intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most enteron aisle spoilage organisms, but beneficial bacteria in human body can be promoted---the growth and breeding of lactobacillus, Bifidobacterium, thus spoilage organisms can be suppressed to grow, contribute to improving and maintaining enteron aisle normal function; Long-term edible can to delay senility, defaecation, raising immunity, the absorptivity that alleviates burden of liver, improve nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, knot intestinal pH is reduced, suppresses the growth of intestinal harmful bacillus; Water-Electrolyte in small intestine is made to be trapped in enteric cavity, produce and highly ooze effect, enterocinesia is stimulated to cause laxative, thus promote the discharge of intestinal endotoxin and other toxicants, lactulose also can directly endotoxin in deactivation enteron aisle, reduce gut pH, extensively model is applied to the treatment of the resistance of enhancing reducing blood lipid;

Prebiotics of the present invention is the extract of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, jerusalem artichoke, cotton seed compound sugar, stachyose, yeast, oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix;

5. carbohydrate: carbohydrate is by carbon, hydrogen and oxygen three kinds of element compositions, it is for human body provides nutrient the most cheap in three of heat energy kinds of main nutrients, when taking in sufficient, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,

Carbohydrate of the present invention refers to Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, trehalose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix;

6. there is the grease of health care to refer to there is health-care effect to the person, and finished product energy can be increased, make the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal); As the street cleaner that fish oil is human vas, can also prevention of arterial sclerosis, apoplexy and heart disease.Fish oil is the diseases such as hypertension, coronary heart disease, headstroke, diabetes, rheumatic arthritis, cancer; Linseed oil has fat-reducing, reduces cholesterol, improves the effects such as renal function; Peony seed oil has reducing blood lipid and hypotensive, strengthens autoimmunity, prevention diabetes, effect of anti-curing cancers; Samara oil prevents and treats hypertension, high fat of blood, effect of the illnesss such as vascular sclerosis;

Of the present invention have the grease of health care to refer to linseed oil, peony seed oil, samara oil, silybum marianum seed oil, phytosterin ester, imperial rice bran oil, tea seed oil, fish oil, fish oil extract, arachidonic acid oil, SPE, DHA algal oil, krill oil, Suaeda salsa seed oil, U.S. rattan fruit oil, rhus glabra oil, medium chain triglyceride, oxhide gelatin, smooth bark Lai wood fruit oil, amygdalus pedunculata pall oil, middle LCFA edible oil, acer truncatum seed oil, Epigallo-catechin gallate (EGCG), triglyceride oil, lutein ester one wherein, several or all mix,

7. amino acid: be divided into essential amino acid and nonessential amino acid, is the base unit forming protein, gives protein specific molecular morphosis, make it have biochemical activity; Absorb appropriate methionine and contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances; Leucine can repair muscle, and control blood sugar, and provide energy to bodily tissue, essential amino acid phenylalanine can suppress cancer growth, can reduce again the toxic and side effect of medicine; Lysine can improve absorption and the utilization of food protein, reaches balanced nutritious, enhancing development; Arginine contributes to changing the ammonia in blood into urea and excreting out; For hyperammonemia, hepatic dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses nervous by vegetative nerve and alimentary canal that is that cause festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improving water flood and adjustment mood;

Amino acid of the present invention refers to Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix;

8. vitamin and mineral matter: vitamin and mineral matter are the nutrients of needed by human, the nutrient of the vitamin added in the present invention to be vitamin and mineral matter be needed by human;

The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K1, vitamin C, Cobastab ₁, Cobastab ₂, Cobastab ₆, Cobastab ₁₂, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix;

The mineral matter added in the present invention is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;

In the present invention, the addition of vitamin and minerals performs with reference to " special medicine purposes formula food general rule ", and existing for 1000g finished product, addition is vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K ₁0.00001g, vitamin C 0.63g, Cobastab ₁0.016g, Cobastab ₂0.016g, Cobastab ₆0.015g, Cobastab ₁₂0.0023g, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine 0.15g, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g;

The present invention with microcapsules, biological enzymolysis, semi-bionic extraction, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or semi-bionic extraction after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, make product prevent and treat diabetes effect and significantly improve compared with the like product of market;

9. adopt above-mentioned integrated innovation technique various batching to be mixed solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving by about 150ml warm water, directly drink or take in through nasal feeding; Add appropriate amount of auxiliary materials make capsule, tablet or add sweetener and black sesame powder is made fast, instant food is convenient to go out carry edible, if make beverage, save spray-dried, add black sesame powder less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out in clean dried environment;

The characteristic of this full nutritional formulas of filling a prescription and the following aspects is mainly manifested in the effect of body:

1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with the constitutive character of diabetic, the achievement in research developments such as the advanced physiology of comprehensive nowadays American Harvard University, medicine, nutrition and clinical practice, vary with each individual, gold compatibility;

2. the present invention is according to the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of ", the Chinese medical extract elite of more than 10 kinds medicine-food two-purposes, multiple probio, prebiotics is adopted to be primary raw material, with small peptide, amino acid, the grease having health care, B B-complex, composite mineral matter auxiliary material, the organic assembling of various batching, various function is merged, and by the synergy between active ingredient, humidification effect;

3. have effective absorbency, utilize formula of the present invention, various component adopts the food of suitable ratio collocation preparation, in isotonic state after a certain amount of water-soluble solution, small intestine can be arrived quickly through stomach, absorb quick, complete, diabetic's desired nutritional can be supplemented rapidly, not increase liver kidney burden;

4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicine, containing several functions active component, not only increase the concentration of function factor, reduce the absorption of various impurity, contribute to alleviating liver kidney burden, have and strengthen the effect of resistance of human body, also have nourishing blood and invigorating qi, the cool blood that detoxifies, relieving restlessness is quenched the thirst, nourishing hepatic yin, clearing lung-heat and prevent and treat diabetes and prevent and treat effects of diabetes;

5. probio contained in the present invention's formula, multiple probio can safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and raising body are to the absorption of calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve host to the tolerance of radioactive ray, lactobacillus significantly increases intestinal mucosal immune globulin A (SIgA) content, to body intestinal mucosa local immunity, there is regulating action, regulate stomach, intestines Tiny ecosystem, calcium can be improved, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, the absorption of cholesterol can also be reduced,

6. formula food of the present invention with the food source property bioactive short peptide in multiple source for nitrogenous source, because small peptide does not need digestion and Absorbable rod, more be conducive to the utilization of body, can effectively improve diabetic's negative nitrogen balance, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa;

7. this prescription have employed this team by the achievement to probio key technology research of field planting mechanism in enteron aisle over nearly 3 years, improve " Chinese medicine of integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence combining prebiotics can play the key elements such as field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity of raising probiotic cell, and therefore the composition of this food formula greatly strengthen the field planting effect to external source probio;

8. prebiotics contained in the present invention's formula, by promoting the growth and breeding of probio in intestines, suppress the growth of spoilage organisms, form one protective barrier at intestinal mucosal surface simultaneously, the damage of enteron aisle spoilage organisms to intestinal mucosa can be resisted, reduce the absorption of intestinal toxic material, intestines peristalsis can also be promoted, accelerate the discharge of residuals in intestines, constipation can be prevented, and by promoting that the growth and breeding of beneficial bacteria of intestinal tract also can strengthen immunity of organisms, the bioactivator such as small peptide and active polysaccharide has synergy;

9. in the present invention's formula, contained carbohydrate is for human body provides three kinds of main nutrients of heat energy, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) that conveys hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce;

10. in the present invention's formula, the contained grease of health care that has not only has health-care effect to the person, and provides the energy needed for normal life for human body, makes the energy contained by the every 100g of finished product of the present invention should be not less than 295kJ (70kcal);

11, contained in the present invention's formula amino acid, it is the base unit forming protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances, muscle can be repaired, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development;

12, formula food of the present invention is containing multivitamin and mineral matter, can supplement rapidly the micronutrient needed for diabetic, small peptide by with the chelating of calcium, iron, zinc etc. after, further increase the absorptivity of mineral matter element;

13, not fatty and cholesterol in the present invention's formula, while supplementary protein, micronutrient, can not increase the absorption of fat, cholesterol, avoid the adverse effect of the high protein diet such as meat, egg.

Detailed description of the invention

Below by following examples, the invention will be further described, and it will contribute to understanding the present invention;

Case study on implementation one

It comprises following component by weight, the extract of medicine-food two-purpose and new resource food: Cordyceps sinensis 8g, stem of noble dendrobium 8g, lucidum spore powder 8g to realize the object of the invention diabetic medicine formula food ,glossy ganoderma 8g, Radix Astragali 12g, rhizoma atractylodis 12g, radix scrophulariae 12g, Radix Angelicae Sinensis 12g, radix paeoniae rubrathe 12g, Ligusticum wallichii 12g, motherwort 12g, red sage root 12g, dried rhizome of rehmannia 12g, cultivated land 12g, wind-weed 12g, the root of straight ladybell 12g, the tuber of dwarf lilyturf 12g, rhizoma alismatis 12g, banksia rose 10g, Cordyceps militaris 12g, line leaf broom top 12g, ampelopsis grossdentata leaf 11g, Euglena 12g, Qingqian Willow leaf 11g, haematococcus pluvialis 10g, Camellia nitidissima 8g, the luxuriant isapgol husk 10g of circle, phoenix peony 12g, the sub-15g of Guangdong Cordyceps militaris, corn stigma 12g, sealwort 11g, lily 11g, root of kudzu vine 10g, balsam pear 10g, cassia seed 9g, Chinese mesona herb 9g, it shellfish 9g ,sessileflower Acanthopanax Bark 9g, dark plum 9g, Radix Glycyrrhizae 9g, Cr-enriched yeast powder 8g, steviol glycoside 8g, barley seedling 6g, hawthorn 6g, roselle 6g, Chinese yam 5g, semen litchi 5g, konjaku 5g, sea-buckthorn 5g, black fungus 5g, tealeaves theanine 10g, chlorella pyrenoidosa 12g, currant lobate layer bacterium fermentation mycelium 12g, Saussurea involucrata culture 12g, first milk basic protein 12g, algae extrats 5g, dragon protein 4g above-mentioned more than three kinds or whole mixtures, multiple probio 300g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, the grease 100g having health care, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K ₁0.00001g, vitamin C 0.63g, Cobastab ₁0.016g, Cobastab ₂0.016g, Cobastab ₆0.015g, Cobastab ₁₂0.0023g, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine 0.15g, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

First by Cordyceps sinensis during making, the stem of noble dendrobium, lucidum spore powder, glossy ganoderma, the Radix Astragali, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, Ligusticum wallichii, motherwort, the red sage root, the dried rhizome of rehmannia, cultivated land, the wind-weed, the root of straight ladybell, the tuber of dwarf lilyturf, rhizoma alismatis, the banksia rose, Cordyceps militaris, line leaf broom top, ampelopsis grossdentata leaf, Euglena, Qingqian Willow leaf, haematococcus pluvialis, Camellia nitidissima, the luxuriant isapgol husk of circle, tealeaves theanine, phoenix peony, Guangdong Cordyceps militaris, corn stigma, sealwort, lily, the root of kudzu vine, balsam pear, cassia seed, Chinese mesona herb, it shellfish ,sessileflower Acanthopanax Bark, dark plum, Radix Glycyrrhizae, barley seedling, hawthorn, roselle, Chinese yam, semen litchi, konjaku, cycloheptaamylose is added after above-mentioned more than three kinds or the whole immersions of sea-buckthorn, after extracting with semi-bionic extraction, spray-dried and preparation flour, add the small peptide that biological enzymolysis extracts again, prebiotics, amino acid, Cr-enriched yeast powder, steviol glycoside, water-soluble dietary fiber, black fungus, algae extrats, chlorella pyrenoidosa, currant lobate layer bacterium fermentation mycelium, Saussurea involucrata culture, first milk basic protein, ground dragon protein, multivitamin and mineral matter are through pulverizing and carrying out pasteurization 1 hour after mixing, then the probio after microencapsulation is added, there is the grease of health care and mix the solid beverage making powdery, granule, and be distributed into 10g/ bag, after dissolving by 150mL warm water, directly drink or take in through nasal feeding, add appropriate amount of auxiliary materials make capsule, tablet or add sweetener and auxiliary material is made fast, instant food is convenient to go out carry edible, if make beverage, save spray-dried, add auxiliary material less, be distributed into 10-65mL/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require,

The present invention with microcapsules, biological enzymolysis, semi-bionic extraction, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or semi-bionic extraction after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat diabetes significantly improves compared with the like product of market.

Case study on implementation two

Above-mentioned diabetic medicine formula food also comprises following component by weight: the extract of medicine-food two-purpose and new resource food: Qingqian Willow leaf 30g, sealwort 30g, Cordyceps militaris 20g, corn stigma 16g, lily 14g, root of kudzu vine 13g, balsam pear 13g, cassia seed 12g, Chinese mesona herb 12g, sky shellfish 12g ,line leaf broom top 11g, ampelopsis grossdentata leaf 11g, Euglena 12g, haematococcus pluvialis 10g, Camellia nitidissima 8g, the luxuriant isapgol husk 10g of circle, tealeaves theanine 10g, phoenix peony 12g, the sub-15g of Guangdong Cordyceps militaris, chlorella pyrenoidosa 12g, currant lobate layer bacterium fermentation mycelium 12g, Saussurea involucrata culture 12g, first milk basic protein 12g, Radix Glycyrrhizae 11g, barley seedling 11g, hawthorn 10g, roselle 10g, Chinese yam 9g, semen litchi 9g, konjaku 9g, sea-buckthorn 8g, black fungus 8g, dark plum 7g, above-mentioned more than three kinds or whole of algae extrats 7g, corn oligopeptide powder 7g, multiple probio 300g, prebiotics 250g after dragon protein 6g, wheat oligopeptide 6g, microencapsulation, small peptide 150g, several amino acids 100g, carbohydrate 100g, the grease 100g having health care, water-soluble dietary fiber 100g, vitamin and mineral matter 25g.

Case study on implementation three

Above-mentioned diabetic medicine formula food also comprises following component by weight: the extract of medicine-food two-purpose: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, probio 250g, small peptide 200g, carbohydrate 150g, the grease 150g having health care, prebiotics 100g, several amino acids 100g.

Case study on implementation four

Above-mentioned diabetic medicine formula food also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Embodiment five

Above-mentioned diabetic medicine formula food also comprises following component by weight: prebiotics 700g, small peptide 500g, carbohydrate 300g, multiple probio 300g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Case study on implementation six

Above-mentioned diabetic medicine formula food also comprises following component by weight: carbohydrate 800g, small peptide 500g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

Claims

1. diabetic medicine formula food, it is characterized in that the constitutive character in conjunction with patients with coronary heart disease, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with the medicinal and edible Chinese medicine extract essence of more than three kinds or whole and new resource food, multiple probio, small peptide for primary raw material, with prebiotics, carbohydrate, amino acid, the medical science formula food that has the grease of health care, multivitamin, several mineral materials to make for auxiliary material;

Fill a prescription by following raw materials according and consumption thereof, the extract of medicine-food two-purpose and new resource food: Cordyceps sinensis 8g, stem of noble dendrobium 8g, lucidum spore powder 8g ,glossy ganoderma 8g, Radix Astragali 12g, rhizoma atractylodis 12g, radix scrophulariae 12g, Radix Angelicae Sinensis 12g, radix paeoniae rubrathe 12g, Ligusticum wallichii 12g, motherwort 12g, red sage root 12g, dried rhizome of rehmannia 12g, cultivated land 12g, wind-weed 12g, the root of straight ladybell 12g, the tuber of dwarf lilyturf 12g, rhizoma alismatis 12g, banksia rose 10g, Cordyceps militaris 12g, line leaf broom top 12g, ampelopsis grossdentata leaf 11g, Euglena 12g, Qingqian Willow leaf 11g, haematococcus pluvialis 10g, Camellia nitidissima 8g, the luxuriant isapgol husk 10g of circle, phoenix peony 12g, the sub-15g of Guangdong Cordyceps militaris, corn stigma 12g, sealwort 11g, lily 11g, root of kudzu vine 10g, balsam pear 10g, cassia seed 9g, Chinese mesona herb 9g, it shellfish 9g ,sessileflower Acanthopanax Bark 9g, dark plum 9g, Radix Glycyrrhizae 9g, Cr-enriched yeast powder 8g, steviol glycoside 8g, barley seedling 6g, hawthorn 6g, roselle 6g, Chinese yam 5g, semen litchi 5g, konjaku 5g, sea-buckthorn 5g, black fungus 5g, tealeaves theanine 10g, chlorella pyrenoidosa 12g, currant lobate layer bacterium fermentation mycelium 12g, Saussurea involucrata culture 12g, first milk basic protein 12g, algae extrats 5g, dragon protein 4g above-mentioned more than three kinds or whole mixtures, add probio 300g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, the grease 100g having health care, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K again ₁0.00001g, vitamin C 0.625g, Cobastab ₁0.016g, Cobastab ₂0.016g, Cobastab ₆0.015g, Cobastab ₁₂0.0023g, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine 0.15g, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,

2. diabetic medicine formula food according to claim 1, it is characterized in that described medicine-food two-purpose Chinese herbal medicine extract and new resource food are Cordyceps sinensis, the stem of noble dendrobium, lucidum spore powder, glossy ganoderma, the Radix Astragali, rhizoma atractylodis, radix scrophulariae, Radix Angelicae Sinensis, the radix paeoniae rubrathe, Ligusticum wallichii, motherwort, the red sage root, the dried rhizome of rehmannia, cultivated land, the wind-weed, the root of straight ladybell, the tuber of dwarf lilyturf, rhizoma alismatis, the banksia rose, Cordyceps militaris, line leaf broom top, ampelopsis grossdentata leaf, Euglena, Qingqian Willow leaf, haematococcus pluvialis, Camellia nitidissima, the luxuriant isapgol husk of circle, tealeaves theanine, phoenix peony, Guangdong Cordyceps militaris, corn stigma, sealwort, lily, the root of kudzu vine, balsam pear, cassia seed, Chinese mesona herb, it shellfish ,sessileflower Acanthopanax Bark, dark plum, Radix Glycyrrhizae, barley seedling, hawthorn, roselle, Chinese yam, semen litchi, konjaku, sea-buckthorn, chlorella pyrenoidosa, currant lobate layer bacterium fermentation mycelium, Saussurea involucrata culture, first milk basic protein, Cr-enriched yeast powder, dragon protein, steviol glycoside, black fungus more than three kinds or whole mixtures wherein.

3. diabetic medicine formula food according to claim 1, is characterised in that and can be prepared into powdery, capsule shape, tablet shape, beverage based food according to described formula mixing.

4. diabetic medicine formula food according to claim 1, also comprises following component by weight: the Chinese medical extract elite of several medicine-food two-purpose and new resource food 400g, prebiotics 350g, small peptide 350g, carbohydrate 300g, the grease 300g, the several amino acids 100g that have health care, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

5. diabetic medicine formula food according to claim 1, also comprises following component by weight: prebiotics 700g, small peptide 500g, carbohydrate 300g, multiple probio 300g, several amino acids 100g, B B-complex and mineral matter 25g; Energy contained by every 100g should be not less than 295kJ (70kcal).

6. diabetic medicine formula food according to claim 1, it is characterized in that described probio all adopt microencapsulation after probio, for Bifidobacterium, lactobacillus, streptococcus thermophilus, Pediococcus acidilactici are wherein a kind of, several or all mix; Wherein Bifidobacterium refers to that bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum, animal bifidobacteria (bifidobacterium lactis) are wherein a kind of, several or all mix; Lactobacillus refers to: lactobacillus acidophilus, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii subspecies, lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus, lactobacillus paraceasi, Lactobacillus crispatus, lactobacillus delbruockii subspecies bulgaricus, lactobacillus reuteri are wherein a kind of, several or all mix.

7. diabetic medicine formula food according to claim 1, it is characterized in that described prebiotics is the extraction mixture of Chinese yam, Poria cocos, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, inulin, cotton seed compound sugar, stachyose, yeast, oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide wherein several or all mix.

8. diabetic medicine formula food according to claim 1, is characterized in that described amino acid is Glu, GABA, pearl Gly-His-Lys, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine wherein several or all mix.

9. diabetic medicine formula food according to claim 1, is characterized in that described carbohydrate is Arabinose, fructose, swan-mussel polysaccharide, resistant dextrin, chitosan oligosaccharide, yeast beta-dextran, polyfructosan, trehalose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.

10. diabetic medicine formula food according to claim 1, is characterized in that described small peptide is marine collagen peptide, maize oligopeptide, wheat oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide is wherein several or all mix.