CN104207144A - High-energy enteral nutrition multi polymerizer - Google Patents

High-energy enteral nutrition multi polymerizer Download PDF

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CN104207144A
CN104207144A CN201410503102.5A CN201410503102A CN104207144A CN 104207144 A CN104207144 A CN 104207144A CN 201410503102 A CN201410503102 A CN 201410503102A CN 104207144 A CN104207144 A CN 104207144A
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oil
vitamin
fiber
poly mixture
powder
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CN104207144B (en
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舒晓亮
钟静霞
杨旭艳
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Nantong Licheng Biological Engineering Co ltd
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Shanghai Richen Nutritional Polytron Technologies Inc
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Abstract

The invention provides a high-energy enteral nutrition multi polymerizer. The total energy of every 100g of the multi polymerizer is 450-500kJ. The energy ratio is as follows: 16-20% of protein, 35-50% of fat and 40-50% of carbohydrate. The multi polymerizer has the advantages of high fat, high energy, low carbohydrate and rich nutrition, meets the nutritional treatment guideline of modern medicine relevant to malignant tumor, has the obvious anti-tumor effect, and can improve the nutrition condition of tumor patients.

Description

A kind of high energy type EA poly mixture
Technical field
The present invention relates to alimentation composition, particularly high energy type EA poly mixture.
Background technology
The present invention relates to nutritional preparation field, along with environment, lifestyle change, tumor incidence also increases year by year.Especially malignant tumour has become the major disease that threatens China resident existence and social development.Malignant tumor patient energy, carbohydrate, fat and protein all have change significantly, the increase of energy consumption and inefficient energy utilization are considered to the underfed reason of tumor mice, the metabolic disorder of three large heat energy nutrients, wherein the most outstanding is abnormal carbohydrate metabolism, main manifestations is that the circulation of lactic acid glucose increases, although glucose utilization accelerates, body is poor to the utilization rate of glucose.
Carcinous dyscrasia is the complicated syndrome that cancer patient exists, and Clinical Manifestations is chronic, carrying out property Body weight loss, and patient is often with apocleisis, satiety and the performance such as weak.Carcinous dyscrasia patient is insensitive or only partly responsive to nutrition treatment, and the sensitiveness of Radiotherapy chemotherapy is declined, and tolerance reduces, and shorten life cycle.Cachexia is to cause cancer patient to have a delicate constitution and a key factor of high case fatality rate.Cachexia patient's sugar, protein, fat metabolism are abnormal, and gluconeogenesis phenomenon is lasting, and the synthetic patient better than body weight control of cancer patient hepatic glucose of body weight consumption increases by 40%.Body fat employ increase and fat consumption to increase be the another characteristic feature of cancer cachexia, this is with Secretion of Catecholamine increase, insulin resistance, tumour or the generation of other tissue also due to release fat factoring.Lipolysis impels the circulation of triacylglycerol aliphatic acid to strengthen, and this cyclic process consumed energy also causes weight loss.Protein metabolism is extremely greater than and synthesizes feature with the increase of total protein turnover rate and protein decomposition.Carcinemia patient increases because muscle protein decomposes and albumen is synthetic reduces, thereby whole body total protein concentration is reduced.
Enteral nutrition product for tumour patient on domestic market is few, is especially applicable to dyscrasia patient still less.Home brands product does not mostly have specific aim on formula Design, and formula is using casein and/or soybean protein as dietary protein origin, and it is single that aliphatic acid forms proportioning.
Summary of the invention
Because of the too fast growth of tumour, especially after organs shifts, body shows energy consumption increase, abnormal carbohydrate metabolism conventionally, lipid mobilization increases and endogenous nitrogen is lost, the present invention is directed to the metabolic characteristic of tumor organism, a kind of high energy type EA poly mixture is provided, improve gross energy, correct metabolic disorder.
The object of the invention is to realize by following measures:
A kind of high energy type EA poly mixture, every 100g gross energy is 450-500kJ, energy proportioning is: protein 16%-20%, fatty 35%-50%, carbohydrate 40%-50%.
Above-mentioned high energy type EA poly mixture, dietary protein origin is lactalbumin, makes it bioavailability the highest.The biological value 104 of lactalbumin, protein effect than 3.2, net utilization 92, three groups of data, higher than lactoprotein (biological value 91, protein effect than 3.1, net utilization 82), casein (biological value 77, protein effect than 2.5, net utilization 76) and soybean protein (biological value 74, protein effect than 2.1, net utilization 61), are all the splendid sources that proteinaceous nutrient supplements.Albumen powder of the present invention is selected one or more in WPC, sepg whey albumen or hydrolyzing lactoalbumin, can absorb to greatest extent albumen, utilize the immunocompetence of immunoglobulin (Ig) and lactoferrin in lactalbumin and anti-oxidation characteristics to improve immunity of organisms simultaneously.
Cancer cachexia fat is employed increase, and the carnitine of body transport aliphatic acid synthetic reduce or from urine excretion increase, cause that the carnitine level in blood plasma and tissue declines, limited LCFA (LCFA) and entered oxidation in mitochondria and utilize.Medium chain fatty acid (MCT) molecular weight is little, hydrolysis rate is faster than LCFA (LCT), and does not need carnitine transhipment, directly arrives liver by portal vein and decomposes produce power, it is 4 times of LCT that MCT digests and assimilates speed, and accretion rate is 10 times of LCT.Clinical trial result shows: MCT is significantly less than LCL and glucose in the growth that stimulates tumour, and MCT can, by the preferential host tissue that enriches, suppress metastases, is used for the treatment of selectively carcinous dyscrasia.MCT does not produce immunosuppressive action to the body under stress situation, and inflammatory reaction, also without facilitation, is more suitable for the stress situations such as operation, wound and is used.Consider the needs of body to essential fatty acid, therefore MCT and LCT are rationally used by a certain percentage ((MCT: LCT is 1: 1) by the present invention.
Fatty powder of the present invention comprises medium chain fatty acid and LCFA, and its source comprises one or more in corn oil, soybean oil, palm oil, coconut oil, olive oil, tea oil, sunflower oil, fish oil and algae oil.Compound by multiple aliphatic acid, the content ratio of adjusting saturated fatty acid, monounsaturated fatty acids, polyunsaturated fatty acid is 1: 1: 1, and the ratio of ω-6 and ω-3 is 10: 1～2: 1, preferably 5: 1～2: 1, and first-selected 2: 1.Added especially the omega-fatty acid of 2-8 part, source forms through spraying after comprising one or both combinations in fish oil, algae oil.Maize germ oil, sunflower oil are rich in ω-6-PUFA and lack ω-3-PUFA.Olive oil, tea-seed oil are rich in monounsaturated fatty acids (MUFA).This Fatty acids composition meets the absorption of tumour patient aliphatic acid.Inhibition tumor cell propagation, promotion tumour cell are broken up, improve tumor patient physique, and the survival rate that improves tumor patient has positive role.The danger that malignant tumour occurs obviously reduces.And can reduce the risk that colon cancer is fallen ill.Can obviously slow down patient with breast cancer's pathology progress, alleviate chemotherapeutics side effect and improve survival rate.
Above-mentioned high energy type EA poly mixture, carbohydrate derives from maltodextrin, not only for body provides energy, also the organoleptic attribute to product and stability exert an influence, and suspending power, viscosity and the transparency of the outward appearance of DE value on finished product of concentrated reflection maltodextrin, mouthfeel, color and luster, solution all have remarkable impact.Maltodextrin DE value of the present invention is 10 to 22, the maltose dextrose that preferably DE is 13-17, and sugariness is lower, and not moisture-sensitive, is difficult to brown stain, modest viscosity, transparency is better.When maltodextrin DE value is lower, though the non-moisture-sensitive of nutrition poly mixture obtaining is difficult to brown stain, suspending power is strong, but product substantially without sweet taste, and viscosity is larger, transparency is lower.When DE value is higher, slightly sweet taste of nutrition poly mixture, has certain moisture absorption, and transparency is higher, and viscosity is lower, but browning reaction can occur.
The present invention also comprises dietary fiber, and described dietary fiber comprises water-soluble dietary fiber and insoluble diedairy fiber, and its amount ratio is 3: 1-1: 3, be more preferably 1: 1.Wherein said soluble dietary fiber derives from one or more combinations in inulin, polydextrose, galactooligosaccharide, FOS, polyfructosan, raffinose, xylo-oligosaccharide, oligoisomaltose, and described insoluble diedairy fiber derives from one or more combinations kind in resistant dextrin, fibre and soya, corn bran fiber, beet fiber, Semen Tritici aestivi fiber, Testa Tritici fiber, common oats fibre, apple fiber.Under the flora effect of human colon road, there is glycolysis in the present invention, generation has and maintains Colon mucosa cell generation and penetrate and upgrade, promote that water and sodium absorb, the SCFA of regulating intestinal canal function, and has minimizing EA induced diarrhea, improves the function of enteron aisle.In the conspicuousness of physiological function of diet fiber and dietary fiber, the ratio of water-soluble dietary fiber and water insoluble dietary fiber has much relations.
The present invention includes maltodextrin 18-40 part, fatty powder 25-45 part, lactalbumin 18-30 part, dietary fiber 3-7 part, medium chain fatty acid 3-5 part, LCFA 3-5 part.
The present invention also comprises zinc and selenium, and its proportioning is zinc 4-6mg/100g, selenium 10-50 μ g/100g.Improving immunocompetence of the present invention, cancer cell specific induction of apoptosis, has pre-anti-cancer to have an effect.Selenium Metabolism thing methane-selenonic acid (CH3SeH) energy cancer cell specific induction of apoptosis, suppresses new vessels and forms, and stops tumor growth or transfer.Clinical evidence shows that zinc deficiency causes T1, the disorder of T2 cell function, and gross tumor volume increases.Selenium Supplement to lung cancer and knot adenomas and precancerous lesion useful, serum selenium level and Incidence of esophageal cancer are remarkable negative correlation.
The present invention combines disease nutrition with integration of drinking and medicinal herbs theory, add especially raw material 1-5 part of integration of drinking and medicinal herbs, and its source comprises the one or more combination in ginseng pulverate, astragalus polyose, wolfberry fruit powder, Chinese caterpillar fungus powder, fruiting bodies of cordyceps militaris powder, donkey-hide gelatin powder.On the basis that ensures body nutritional need, improve patient's autoimmunity on the one hand, alleviate bad reaction thereby reach; Utilize on the other hand the active material performance antitumor activity of integration of drinking and medicinal herbs raw material, the auxiliary tumor growth that suppresses, the toxic and side effect of minimizing medicine, improves tumour patient quality of life.Inflammatory reaction plays a significant role in tumour immunity, and the present invention can change tumor microenvironment, reaches and suppresses the inflammatory reaction of tumour and improve immunity of organisms, inhibition cancer cell propagation.The present invention has anti-oxidative damage, regulates effect of immunologic function and inflammatory reaction, can strengthen monocytes/macrophages phagocytic function, stimulate T, bone-marrow-derived lymphocyte propagation, strengthen the lymphopoiesis effect of ConA, PHA induction, and can exert an influence to many cell factors; And can raise CD3+, CD4+ cell subsets, lower CD8+ cell subsets, make CD4+/CD8+ ratio increase, improve the concentration of IgA, IgG, human body cell and HI be had to humidification; And the level that can reduce the interior tumor necrosis factor α of liver and IL-1 β, suppresses the level of transforming growth factor β and hydroxyproline, thereby alleviates the degree of injury of hepatocellular necrosis and liver; And can improve the immunosupress of rat traumatic hemorrhagic shock, TNF after medication (TNF-A) discharges and the phagocytic activity of macrophage obviously improves.
The present invention is meeting on the basis of the conventional nutritional need of body, also comprise arginine≤4 part, glutamine≤4 part, wherein arginic source comprises one or more combinations in L-arginine, L-R-gene, L-arginine-aspartic acid, the source of glutamine is Glu.Make the present invention increase to a certain extent the immunity of body to tumour cell.
In the present composition, add insoluble diedairy fiber and mineral matter, easily occur precipitation reconstituting in process.In order to improve the structural state of product, improve the suspension stability of product, in raw material of the present invention, also add by weight xanthans, by adjusting the addition of xanthans, can stable suspersion after product of the present invention reconstitutes more than 8 hours.
Above-mentioned tumorous type EA poly mixture, primary raw material is made by weight: maltodextrin 18-40 part, fatty powder 25-45 part, PURE WHEY 18-30 part, dietary fiber 3-7 part, B B-complex 2-5 part, composite mineral matter 2-5 part, 0.3 part of ginseng pulverate, 1.5 parts of wolfberry fruit powder, 0.5 part, fruiting bodies of cordyceps militaris powder, 0.5 part of astragalus polyose, 1.2 parts, donkey-hide gelatin, essence 0.1-0.4 part.Described B B-complex is made up of vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, pyridoxamine, cobalamin, niacinamide, pantothenic acid, vitamin C, folic acid, biotin, taurine, and described composite mineral matter is made up of sodium, potassium, calcium, magnesium, phosphorus, zinc, iron, copper, manganese, iodine, selenium, chlorine.Lactalbumin in the present invention, omega-3 polyunsaturated fatty acids, integration of drinking and medicinal herbs food materials coordinated, has improved immunity of organisms, delays and ameliorate tumor pathology process.The present invention is directed to the present situation of market product, develop a kind of EA heteropolymer for the variation of tumors of nutrients metabolism substrate and nutrition psychological need, formula is using lactalbumin as dietary protein origin, aliphatic acid comprehensively and form proportioning equilibrium, strengthening omega-3 polyunsaturated fatty acids, excavate the theoretical marrow of traditional integration of drinking and medicinal herbs and add application ginseng pulverate, fruiting bodies of cordyceps militaris powder, donkey-hide gelatin powder, wolfberry fruit powder, astragalus polyoses etc. have the food materials of obvious biologic activities, by rational formula Design, each composition coordinated reaches correction metabolic disorder, improve immunity of organisms, reduce the toxic and side effect of medicine, the quality of making the life better, extend malignant tumor patient life cycle.
Above-mentioned tumorous type EA poly mixture, is specially adapted to the nutritional support treatment of tumour patient chemicotherapy phase tumour patient.
Beneficial effect
1. the present invention has the feature of higher fatty acid, high-energy, low-carb, full nutrition, more meet the nutrition treatment guide of modern medicine about malignant tumour, there is obvious antitumor action, can improve the nutrition condition of tumor patient, our result of study shows, high energy type EA of the present invention is used for postoperative the 7th day of PATIENTS WITH LARGE BOWEL, and patient's nutritional status obviously improves, and plasma A LB, PA, FP level obviously raise.
2. the present invention adds especially omega-3 polyunsaturated fatty acids and has the tumour inflammation of inhibition, suppress tumor growth, improve the special efficacy of immunity of organisms, research shows that omega-fatty acid has strong antiinflammatory action, as suppress the generation of PGE2 etc., can grow by inhibition tumor cell, be suitable for tumor patient and use.High energy type EA of the present invention is used for postoperative the 7th day of PATIENTS WITH LARGE BOWEL, and blood samples of patients TNF-α, IL-1 and CRP are starkly lower than preoperative.CRP, IL-1, TNF-α be important inflammatory mediator and reflect the body inflammatory extent of reaction, and clinical research shows that the present invention is by reducing inflammatory factor TNF-α, CRP and IL-1 level control part and systemic inflammatorome level, thereby reaches antitumor object.
3. the present invention combines disease nutrition with traditional integration of drinking and medicinal herbs theory, improves patient's autoimmunity on the one hand on the basis that ensures body nutritional need, alleviates bad reaction thereby reach; Utilize on the other hand the antitumor activity of each component, assist and suppress tumor growth, reduce the toxic and side effect of medicine, improve the quality of life of tumour patient.High energy type EA of the present invention is used for postoperative the 7th day of PATIENTS WITH LARGE BOWEL, and patient CD4+/CD8+ ratio is apparently higher than preoperative.Tumor immunity main manifestations is the cellular immunity of T cell mediated.T lymphocyte subset group CD4+, CD8+ and CD4+/CD8+ ratio are the sensitive indicators of reflection immunity of organism level, CD4+ level raises, the increase of CD4+/CD8+ ratio shows that immunity of organisms strengthens, show that power has the effect that improves patients with colorectal cancer operation cellular immune level, this development to containment colorectal cancer may be effective.
4. the invention provides a kind of special enteral nutritional composition for tumour patient metabolic characteristic.This formulation product has the feature of high-energy, higher fatty acid, high protein, low-carb, can correct the metabolic disorder having occurred; Formula is using lactalbumin as dietary protein origin, bring into play to greatest extent the biological value of albumen, the special interpolation of formula has the food materials of obvious biologic activities etc., and formula is focused on aliphatic acid comprehensively and formed proportioning equilibrium, strengthens omega-3 polyunsaturated fatty acids, by rational formula Design, reach correction metabolic disorder, improve immunity of organisms, reduce the toxic and side effect of medicine, improve tumour patient quality of life, extend malignant tumor patient life cycle.
Detailed description of the invention
Below by embodiment, the present invention is specifically described; be necessary to be pointed out that at this; following examples are only used to further illustrate the present invention; can not be interpreted as limiting the scope of the invention, these those skilled in the art can make some nonessential improvement and adjustment to the present invention according to the invention described above content.
Embodiment 1
A kind of high energy type EA poly mixture, in parts by weight, composed of the following components:
30 parts of fatty powders, by coconut oil, soybean oil, olive oil, linseed oil according to 2: 4: 2: after 1 weight ratio is mixed, after mixing with casein sodium, obtain emulsion through homogeneous, then emulsion being atomized into drop is injected in the spray drying device that contains powder embedding material and is dried, obtain fatty powder through screening again, fat content is 50%; 2 parts, fish oil; 3 parts of algae oil.It is 1: 1: 1 that this fatty raw material makes the content ratio of saturated fatty acid, monounsaturated fatty acids, polyunsaturated fatty acid, and the content ratio of ω-6 and ω-3 is 2: 1.Dietary protein origin: 13.5 parts of WPCs, 8 parts, sepg whey albumen; Carbohydrate source: 25 parts of maltodextrins; Dietary fiber: 2 parts of inulin, 1 part of polydextrose, 2 parts of Semen Tritici aestivi fibers; 5 parts of medium chain fatty acids (BASF AG), 5 parts of LCFAs (BASF AG); 2 parts of B B-complexes (vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, pyridoxamine, cobalamin, niacinamide, pantothenic acid, vitamin C, folic acid, biotin, taurine); 2 parts of composite mineral matters (sodium, potassium, calcium, magnesium, phosphorus, iron, copper, manganese, iodine, chlorine); Zinc 6mg/100g, selenium 50 μ g/100g, 0.5 part of ginseng pulverate; 1.5 parts of wolfberry fruit powder; 0.5 part, fruiting bodies of cordyceps militaris powder; 0.3 part of xanthans; 0.2 part, essence.
High energy type EA poly mixture of the present invention (seminar) is postoperative for PATIENTS WITH LARGE BOWEL with Nutrison Fibre (control group), during two groups of patient's researchs, accept Enteral Nutritional Support 7d, two groups of patients serum ALB, PA, FA level are before operation, and comparing difference is without significant before blood sugar, T-CHOL, triglycerides, creatinine, urea nitrogen variation and operation, between two groups, each index comparing difference is without significant (table 1).With control group and preoperative comparison, the patient of seminar postoperative the 7th day blood TNF-α, IL-1 and CRP level obviously decline, and with preoperative comparison, control group IL-1, TNF-α and CRP level are without significant.With control group and preoperative comparison, postoperative the 7th day blood CD4 of seminar +/ CD8 +ratio increases; And CD4 +, CD8 +change without significant.Control group duration of test immune indexes changes without significant (table 2).Experimental data proves: the tumorous type EA poly mixture of the present embodiment can improve malnutrition, adjusting inflammatory reaction and the enhanced machine body immunity function of patients with colorectal cancer, is one high energy type EA safely and effectively.
Table 1 seminar and the comparison of control group enteral nutrition treatment effect
* with before operation compare P < 0.0
The comparison of two groups of Plasma Inflammation Factor Levels In Patients of table 2 and immune level level
Above-mentioned experimental data proves: the tumorous type EA poly mixture of the present embodiment can improve malnutrition, adjusting inflammatory reaction and the enhanced machine body immunity function of patients with colorectal cancer, is one high energy type EA safely and effectively.
Embodiment 2
A kind of tumorous type EA poly mixture, in parts by weight, composed of the following components:
(corn oil, palm oil, coconut oil, tea oil, sunflower oil were according to 2: 4: 2: after the weight ratio of 1: 1 is mixed for 29 parts of fatty powders, after mixing with casein sodium, obtain emulsion through homogeneous, then emulsion is atomized into drop and is injected in the spray drying device that contains powder embedding material and is dried, then obtain fatty powder through screening); 2.5 parts, fish oil; 2.5 parts of algae oil; It is 1: 1: 1 that this fatty raw material makes the content ratio of saturated fatty acid, monounsaturated fatty acids, polyunsaturated fatty acid, and the content ratio of ω-6 and ω-3 is 2: 1.
20 parts of WPCs; 3.5 parts of hydrolyzing lactoalbumins;
20.4 parts of maltodextrins;
1 part of inulin; 0.5 part of xylo-oligosaccharide; 1 part of common oats fibre; 0.5 part of resistant dextrin;
Zinc 4-6mg/100g, selenium 10-50 μ g/100g;
5 parts of medium chain fatty acids (BASF AG), 5 parts of LCFAs (BASF AG);
4 parts of arginine, 4 parts of glutamine, wherein arginic source comprises L-arginine, L-R-gene, L-arginine-aspartic acid mixed in equal amounts, the source of glutamine is Glu.
0.3 part of ginseng pulverate; 1.5 parts of wolfberry fruit powder; 0.5 part of astragalus polyose; 1.2 parts, donkey-hide gelatin powder; 0.4 part of xanthans; 0.2 part, essence.
High energy type EA poly mixture of the present invention is used for postoperative the 7th day of PATIENTS WITH LARGE BOWEL, clinical studies show PATIENTS WITH LARGE BOWEL nutritional status obviously improves, plasma A LB, PA, FP level obviously raise, and blood samples of patients inflammatory mediator TNF-α, IL-1 and CRP obviously reduce, and blood CD4 +/ CD8 +value obviously raises.The tumorous type EA poly mixture of the present embodiment can improve malnutrition, adjusting inflammatory reaction and the enhanced machine body immunity function of patients with colorectal cancer, is one high energy type EA safely and effectively.
Embodiment 3
A kind of tumorous type EA poly mixture, in parts by weight, composed of the following components:
25 parts of fatty powders are (by soybean oil, palm oil, olive oil, tea oil according to 2: 4: 2: after 1 weight ratio is mixed, after mixing with casein sodium, obtain emulsion through homogeneous, then emulsion is atomized into drop and is injected in the spray drying device that contains powder embedding material and is dried, then obtain fatty powder through screening); 3 parts, fish oil; 3 parts of algae oil; It is 1: 1: 1 that this fatty raw material makes the content ratio of saturated fatty acid, monounsaturated fatty acids, polyunsaturated fatty acid, and the content ratio of ω-6 and ω-3 is 2: 1.
13.5 parts, sepg whey albumen; 6.5 parts of hydrolyzing lactoalbumins;
28.3 parts of maltodextrins;
1 part of raffinose; 1 part of oligoisomaltose; Inulin 1g; 2 parts of resistant dextrins; Apple fiber 1g;
2 parts of B B-complexes (vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, pyridoxamine, cobalamin, niacinamide, pantothenic acid, vitamin C, folic acid, biotin, taurine mixed in equal amounts composition); 2 parts of composite mineral matters (sodium, potassium, calcium, magnesium, phosphorus, iron, copper, manganese, iodine, chlorine mixed in equal amounts composition);
3 parts of MCT; LCT3 part;
0.5 part of ginseng pulverate; 0.5 part, fruiting bodies of cordyceps militaris powder; 2 parts, donkey-hide gelatin powder; 0.4 part of xanthans; 0.3 part, essence.
High energy type EA poly mixture of the present invention is used for postoperative the 7th day of PATIENTS WITH LARGE BOWEL, clinical studies show PATIENTS WITH LARGE BOWEL nutritional status obviously improves, plasma A LB, PA, FP level obviously raise, and blood samples of patients inflammatory mediator TNF-α, IL-1 and CRP obviously reduce, and blood CD4 +/ CD8 +value obviously raises.The tumorous type EA poly mixture of the present embodiment can improve malnutrition, adjusting inflammatory reaction and the enhanced machine body immunity function of patients with colorectal cancer, is one high energy type EA safely and effectively.
Embodiment 4
A kind of tumorous type EA poly mixture, in parts by weight, composed of the following components:
33 parts of fatty powders are (by corn oil, palm oil, coconut oil, olive oil, sunflower oil according to 2: 4: 1: after the weight ratio of 2: 1 is mixed, after mixing with casein sodium, obtain emulsion through homogeneous, then emulsion is atomized into drop and is injected in the spray drying device that contains powder embedding material and is dried, then obtain fatty powder through screening); 2 parts, fish oil; 2 parts of algae oil; It is 1: 1: 1 that this fatty raw material makes the content ratio of saturated fatty acid, monounsaturated fatty acids, polyunsaturated fatty acid, and the content ratio of ω-6 and ω-3 is 2: 1.
12.5 parts of WPCs; 6 parts, sepg whey albumen; 4 parts of hydrolyzing lactoalbumins;
18.3 parts of maltodextrins;
1 part of xylo-oligosaccharide; 2 parts of polydextroses; 2 parts of resistant dextrins; 1 part of fibre and soya;
2 parts of B B-complexes (vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, pyridoxamine, cobalamin, niacinamide, pantothenic acid, vitamin C, folic acid, biotin, taurine); 2 parts of composite mineral matters (sodium, potassium, calcium, magnesium, phosphorus, iron, copper, manganese, iodine, chlorine);
3 parts of MCT; LCT3 part;
0.3 part of ginseng pulverate; 0.5 part, fruiting bodies of cordyceps militaris powder; 1.2 parts, donkey-hide gelatin powder; 1.5 parts of wolfberry fruit powder; 0.4 part of xanthans; 0.3 part, essence.
High energy type EA poly mixture of the present invention is used for postoperative the 7th day of PATIENTS WITH LARGE BOWEL, clinical studies show PATIENTS WITH LARGE BOWEL nutritional status obviously improves, plasma A LB, PA, FP level obviously raise, and blood samples of patients inflammatory mediator TNF-α, IL-1 and CRP obviously reduce, and blood CD4 +/ CD8 +value obviously raises.The tumorous type EA poly mixture of the present embodiment can improve malnutrition, adjusting inflammatory reaction and the enhanced machine body immunity function of patients with colorectal cancer, is one high energy type EA safely and effectively.

Claims (11)

1. a tumorous type EA poly mixture, the gross energy of every 100g is 450-500kJ, energy proportioning is: protein 16%-20%, fatty 35%-50%, carbohydrate 40%-50%.
2. tumorous type EA poly mixture as claimed in claim 1, dietary protein origin is lactalbumin, lactalbumin is selected one or more in WPC, sepg whey albumen or hydrolyzing lactoalbumin.
3. tumorous type EA poly mixture as claimed in claim 1 or 2, adipose-derived one or more in corn oil, soybean oil, palm oil, coconut oil, olive oil, tea oil, sunflower oil, fish oil and algae oil, in described fat, the content of saturated fatty acid, monounsaturated fatty acids, polyunsaturated fatty acid is than being 1:1:1, the ratio of ω-6 aliphatic acid and omega-fatty acid is 10:1～2:1, preferably 5:1～2:1, more preferably 2:1.
4. the tumorous type EA poly mixture as described in claim 1,2 or 3, carbohydrate derives from maltodextrin; Preferred maltodextrin DE value is 10 to 22, the maltose dextrose that more preferably DE is 13-17.
5. the tumorous type EA poly mixture as described in claim 1,2,3 or 4, also comprises dietary fiber, and described dietary fiber comprises water-soluble dietary fiber and insoluble diedairy fiber, and its amount ratio is 3:1-1:3, is more preferably 1:1; Wherein said soluble dietary fiber derives from one or more combinations in inulin, polydextrose, galactooligosaccharide, FOS, polyfructosan, raffinose, xylo-oligosaccharide, oligoisomaltose, and described insoluble diedairy fiber derives from one or more combinations kind in resistant dextrin, fibre and soya, corn bran fiber, beet fiber, Semen Tritici aestivi fiber, Testa Tritici fiber, common oats fibre, apple fiber.
6. the tumorous type EA poly mixture as described in as arbitrary in claim 1-5, also comprises medium chain fatty acid (MCT) and LCFA (LCT), and MCT:LCT content ratio is preferably 1:1.
7. the tumorous type EA poly mixture as described in as arbitrary in claim 1-6, also comprises zinc and selenium, and its proportioning is zinc 4-6mg/100g, selenium 10-50 μ g/100g.
8. the tumorous type EA poly mixture as described in as arbitrary in claim 1-7, the raw material 1-5 part that also comprises integration of drinking and medicinal herbs, its source comprises one or more in ginseng pulverate, astragalus polyose, wolfberry fruit powder, Chinese caterpillar fungus powder, fruiting bodies of cordyceps militaris powder, donkey-hide gelatin powder.
9. the tumorous type EA poly mixture as described in as arbitrary in claim 1-8, also comprise arginine≤4 part, glutamine≤4 part, wherein arginic source comprises one or more combinations in L-arginine, L-R-gene, L-arginine-aspartic acid, and the source of glutamine is Glu.
10. the tumorous type EA poly mixture as described in as arbitrary in claim 1-9, also comprises 0.2-0.8 part xanthans.
11. tumorous type EA poly mixture as described in as arbitrary in claim 1-10, make by following weight portion: maltodextrin 18-40 part, fatty powder 25-45 part, PURE WHEY 18-30 part, dietary fiber 3-7 part, B B-complex 2-5 part, composite mineral matter 2-5 part, 0.3 part of ginseng pulverate, 1.5 parts of wolfberry fruit powder, 0.5 part, fruiting bodies of cordyceps militaris powder, 0.5 part of astragalus polyose, 1.2 parts, donkey-hide gelatin, essence 0.1-0.4 part; Described B B-complex is made up of vitamin A, vitamin D, vitamin E, vitamin K, vitamin B1, vitamin B2, pyridoxamine, cobalamin, niacinamide, pantothenic acid, vitamin C, folic acid, biotin, taurine, and described composite mineral matter is made up of sodium, potassium, calcium, magnesium, phosphorus, zinc, iron, copper, manganese, iodine, selenium, chlorine.
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CN105410932A (en) * 2015-11-03 2016-03-23 北京赛升药业股份有限公司 Tumor immunity type nutritional composition and application thereof
CN106880035A (en) * 2015-12-15 2017-06-23 范旻 A kind of total enteral nutritious product of regulating intestinal canal flora imbalance and preparation method thereof
CN107440088A (en) * 2016-06-01 2017-12-08 华仁药业股份有限公司 Improve operation, the nutrients and preparation method thereof of chemicotherapy tumor patient immunity
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CN106579460A (en) * 2016-12-23 2017-04-26 上海奥医生物医药科技有限公司 Special clinical nutrition formula for fracture and preparation method thereof
CN106983136A (en) * 2017-03-29 2017-07-28 上海奥医生物医药科技有限公司 A kind of puerperium conditioning tailored version clinical nutrition formula and preparation method thereof
CN106942748A (en) * 2017-03-29 2017-07-14 上海奥医生物医药科技有限公司 A kind of female acyesis tailored version clinical nutrition formula and preparation method thereof
EP3632223A4 (en) * 2017-05-26 2021-03-10 Kabushiki Kaisha Yakult Honsha Oligosaccharide powder and method for manufacturing same
US11390691B2 (en) 2017-05-26 2022-07-19 Kabushiki Kaisha Yakult Honsha Oligosaccharide powder and method for manufacturing same
CN107279993A (en) * 2017-06-12 2017-10-24 金梅 A kind of alimentation composition for promoting patients with gastric cancer early postoperation to recover and its application
CN107594540A (en) * 2017-11-05 2018-01-19 耿德铨 Help and breed nutriment composite powder and preparation method thereof
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CN112075636A (en) * 2019-11-06 2020-12-15 上海张新生物医药科技有限公司 Formula of nutrition support fat component for tumor patients and preparation method of microcapsule powder of nutrition support fat component
CN110897153A (en) * 2019-11-26 2020-03-24 北京诺康达医药科技股份有限公司 Nutritional preparation suitable for patients with kidney disease dialysis
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