CN106036885A - Enteral nutrition emulsion fed through nasointestinal tube and applied to severe and postoperative patients and preparation method of enteral nutrition emulsion - Google Patents
Enteral nutrition emulsion fed through nasointestinal tube and applied to severe and postoperative patients and preparation method of enteral nutrition emulsion Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
- A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
- A23D9/007—Other edible oils or fats, e.g. shortenings, cooking oils characterised by ingredients other than fatty acid triglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an enteral nutrition emulsion fed through a nasointestinal tube and applied to severe and postoperative patients and a preparation method of the enteral nutrition emulsion, and belongs to the technical field of nutritious food preparations. The enteral nutrition emulsion has a reasonable formula and comprehensive nutrients, and is prepared from ginseng flower extract, oat bran powder, broken cell wall chlorella powder, hericium erinaceus polysaccharide, phellinus igniarius polysaccharide and the like, is rich in various nutrients, can fully supplement severe and postoperative patients with high-quality protein, fat, carbohydrate, dietary fibers, vitamins, minerals and other substances, is easily absorbed by human bodies, can improve the nutrition state of the critically ill patients and postoperative patients in the short term and strengthen gastrointestinal tract functions of the critically ill patients and postoperative patients, enables the body to recover immunity, and shortens the hospitalization time; besides, the enteral nutrition emulsion fed through the nasointestinal tube has good tolerance without any side effects.
Description
Technical field
The invention belongs to nutraceutical preparation technical field, particularly belong to a kind of serious symptom and the postoperative enteral through nasointestinal tube row
Nutrient and preparation method thereof.
Background technology
For a lot of serious symptoms and postoperative patient, due to extremely feeble cannot laboratory rodent chow, and digestive system machine
Can be limited, often in undernutrition state, it is unfavorable for physical rehabilitation.Therefore, they need by liquid food supplement the nutrients with
Regain one's strength.Along with enteral total nutrient is the most gradually paid attention to by the development people of medical level, increasing enteral total nutrient element
Instead of traditional liquid food, provide nutritional supplementation the most easily for patient with severe symptoms.Professional Medical Degree (Clinical
Nutrition support) it is generally thought to comprise per os, intestinal or parenteral approach and provides more comprehensive nutrient, mesh for patient
Before include parenteral nutrition (Parenteral nutrition, PN) and enteral nutrition (Enteralnutrition, EN).Clinical work
In work, as long as intestinal has absorption function, and safety, then first-selected enteral nutrition.Clinically, commonly used nasogastric tube is carried out
EN support.But in process of clinical application, owing to patient with severe symptoms and part postoperative patient majority exist the former of gastroparalysis
Cause, causes enteral nutrition time retardation, gastric content reflux occurs, the danger even by mistake inhaled, therefore this type of patient's many employings nose
Jejunum pipe carries out EN support.
At present, market occurred number of types of enteral nutrition preparation, such as " Nutrison Fibre ", " Wei Wo ", " supportan ",
The product of " peace element " etc..These product protein majorities are vegetable protein, and research shows, vegetable protein majority is incomplete egg
In vain, the absorption for protein of serious symptom and postoperative patient it is unfavorable for.In order to overcome the defect of current Enteral Nutritional Emulsion, China is specially
Profit CN 101785560 B discloses " a kind of enteral nutrition preparation and preparation method and application " this invention enteral nutrition system
Agent use marine protein peptide and soybean peptide be protein sources, Semen Maydis oil and fish oil be adipose-derived, maltodextrin is carbon aquation
Compound is originated, and seawater spirulina and fruit vegetable powder provide vitamin and mineral.Although on the one hand oceanic biological active peptides source is wide
General, performance is gentle, and function is numerous, safe and free of toxic and side effects, is widely applied in industries such as medicine, food, cultivation, but
It is that the research also having many bioactive peptide is under test, only by mouse test and in vitro tests, its safety non-toxic is described,
In vivo with application effect in terms of research less, the most sufficiently develop and useedd.On the other hand the enteral of this invention
Nutrition emulsion Analysis of Nutritive Composition lacks dietary fiber, and the gastrointestinal peristalsis of gastrointestinal dysfunction patient and intestinal mucosa structure
All is there are the symptoms such as constipation by reduction in various degree in function, and dietary fiber can be wriggled in facilitating digestion road, improves constipation etc.
Symptom.
Summary of the invention
Present invention aims to defect or deficiency that existing Elental exists, it is provided that a kind of serious symptom and postoperative
Elental through nasointestinal tube row and preparation method thereof.
To achieve these goals, the technical solution used in the present invention is as follows:
Serious symptom and the postoperative Elental through nasointestinal tube row, be made up of the component of following parts by weight: Flos Ginseng extracts
Liquid 30-70 part, Herba bromi japonici bran corium farinosum 5-15 part, breaking wall of chlorella powder 10-20 part, Hericium Erinaceus Polysaccharide 5-20 part, phellin polysaccharides 5-20
Part, vegetable oil 15-30 part, starch sodium octenyl succinate 1-3 part, carrageenan 1-3 part；Described vegetable oil is according to seed of Fructus Hippophae
Oil: almond oil: Oleum Camelliae: walnut oil=1:2:2:1 weight ratio mixes.
Described serious symptom and the postoperative Elental preparation method through nasointestinal tube row, specifically include following steps:
1., select fresh, free from admixture, natural in color Flos Ginseng, soak in the sodium chloride solution that concentration is 2mol/l
60min, is dried to constant weight after taking-up in 40 DEG C of environment, pulverizes 80 mesh sieves, decocts after soaking 3min with 70 ± 5 DEG C of hot distilled waters
Boil 30min, obtain Flos Ginseng's extracting solution, standby；
2., by bran of Fagopyrum esculentum Moench through micronizing, cross 200 mesh sieves, obtain Herba bromi japonici bran corium farinosum, standby；
3., take hericium erinaceus fruiting body, be cut into the thick thin slice of 1cm, be dried to constant weight in 50 DEG C of environment, add Hericium erinaceus (Bull. Ex Fr.) Pers.
Dry product weight 2.5% cellulase solution, puts in 45 DEG C of calorstats, and insulation reaction 45min puts into 80 DEG C after then taking out
Being dried in baking oven, crushed after being dried crosses 200 mesh sieves, adds 90 DEG C of hot water constant temperature extraction 3h of its dry powder weight 2 times, in centrifuging and taking
Clear liquid, lyophilization, obtain Hericium Erinaceus Polysaccharide, standby；
4., Herba bromi japonici bran corium farinosum, breaking wall of chlorella powder, Hericium Erinaceus Polysaccharide and phellin polysaccharides are added sequentially to Flos Ginseng extract
In liquid, high speed shear under the rotating speed of 3000r/min, after raw material is completely dissolved, add the octene of parts by weight described in formula
Base succinic acid starch sodium, continues to shear 5min, adds vegetable oil and the carrageenan of described parts by weight, continues to shear 45min,
Obtain colostrum；Then, under the pressure of 800bar, with high pressure homogenizer homogenizing 3 times, Elental is obtained.
Described phellin polysaccharides, breaking wall of chlorella powder, vegetable oil, starch sodium octenyl succinate, carrageenan are commercially available
Product, all meet national food hygienic standard.
The beneficial effects of the present invention is: the Enteral Nutritional Emulsion formula of the present invention is reasonable, comprehensive nutrition is carried by Flos Ginseng
Take the compositions such as liquid, Herba bromi japonici bran corium farinosum, breaking wall of chlorella powder, Hericium Erinaceus Polysaccharide, phellin polysaccharides, rich in various nutrients, it is possible to for
Serious symptom and patient with operation fully supplement the materials such as high-quality protein, fat, carbohydrate, dietary fiber, vitamin, mineral,
It is easily absorbed by the human body, it is possible to improve critical illness and postoperative patient nutritional status, strengthening critical illness and postoperative patient gastrointestinal in a short time
The function in road so that physical recovery immunity, shortens and leaves hospital the time, and the present invention tolerates through the Elental of nasointestinal tube row
Property is good, without any side effects.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
Embodiment 1
Serious symptom and the postoperative Elental through nasointestinal tube row, be made up of the component of following parts by weight: Flos Ginseng extracts
Liquid 30 parts, Herba bromi japonici bran corium farinosum 5 parts, 10 parts of breaking wall of chlorella powder, Hericium Erinaceus Polysaccharide 5 parts, phellin polysaccharides 5 parts, vegetable oil 15 parts, pungent
1 part of starch alkenyl succinate sodium, carrageenan 1 part.
Described serious symptom and the postoperative Elental preparation method through nasointestinal tube row, specifically include following steps:
1., select fresh, free from admixture, natural in color Flos Ginseng, soak in the sodium chloride solution that concentration is 2mol/l
60min, is dried to constant weight after taking-up in 40 DEG C of environment, pulverizes 80 mesh sieves, decocts after soaking 3min with 70 ± 5 DEG C of hot distilled waters
Boil 30min, obtain Flos Ginseng's extracting solution, standby；
2., by bran of Fagopyrum esculentum Moench through micronizing, cross 200 mesh sieves, obtain Herba bromi japonici bran corium farinosum, standby；
3., take hericium erinaceus fruiting body, be cut into the thick thin slice of 1cm, be dried to constant weight in 50 DEG C of environment, add Hericium erinaceus (Bull. Ex Fr.) Pers.
Dry product weight 2.5% cellulase solution, puts in 45 DEG C of calorstats, and insulation reaction 45min puts into 80 DEG C after then taking out
Being dried in baking oven, crushed after being dried crosses 200 mesh sieves, adds 90 DEG C of hot water constant temperature extraction 3h of its dry powder weight 2 times, in centrifuging and taking
Clear liquid, lyophilization, obtain Hericium Erinaceus Polysaccharide, standby；
4., Herba bromi japonici bran corium farinosum, breaking wall of chlorella powder, Hericium Erinaceus Polysaccharide and phellin polysaccharides are added sequentially to Flos Ginseng extract
In liquid, high speed shear under the rotating speed of 3000r/min, after raw material is completely dissolved, add the octene of parts by weight described in formula
Base succinic acid starch sodium, continues to shear 5min, adds vegetable oil and the carrageenan of described parts by weight, continues to shear 45min,
Obtain colostrum；Then, under the pressure of 800bar, with high pressure homogenizer homogenizing 3 times, Elental is obtained.
Described phellin polysaccharides, breaking wall of chlorella powder, vegetable oil, starch sodium octenyl succinate, carrageenan are commercially available
Product, all meet national food hygienic standard.
Embodiment 2
Serious symptom and the postoperative Elental through nasointestinal tube row, be made up of the component of following parts by weight: Flos Ginseng extracts
Liquid 60 parts, Herba bromi japonici bran corium farinosum 12 parts, 15 parts of breaking wall of chlorella powder, Hericium Erinaceus Polysaccharide 18 parts, phellin polysaccharides 16 parts, vegetable oil 20
Part, starch sodium octenyl succinate 1.5 parts, carrageenan 1.5 parts.
The serious symptom of embodiment 2 and the postoperative Elental preparation method through nasointestinal tube row are with the preparation described in embodiment 1
Method is consistent.
Embodiment 3
Serious symptom and the postoperative Elental through nasointestinal tube row, be made up of the component of following parts by weight: Flos Ginseng extracts
Liquid 70 parts, Herba bromi japonici bran corium farinosum 15 parts, 20 parts of breaking wall of chlorella powder, Hericium Erinaceus Polysaccharide 20 parts, phellin polysaccharides 20 parts, vegetable oil 30
Part, starch sodium octenyl succinate 3 parts, carrageenan 3 parts.
The serious symptom of embodiment 3 and the postoperative Elental preparation method through nasointestinal tube row are with the preparation described in embodiment 1
Method is consistent.
Vegetable oil described in embodiment 1 to embodiment 3 is according to Fructrs Hippophae seed oil: almond oil: Oleum Camelliae: walnut oil=1:2:
2:1 weight ratio mixes.
Clinical data
1, physical data: choose in January, 2013 Intensive Care Therapy in January ,-2016 section of 60 example hospital Cavity in Critical Patients, age
Scope is: 20-68 year；APACHE II 15-25 that marks divides；All without the digestion of obvious intestinal, malabsorption, but because of mechanical ventilation
Or disturbance of consciousness can not oral feeding, need row nutritional support.
3, packet: use the method for random packet to be divided into two groups.(1) matched group (Nutrison Fibre group) (Nutrison Fibre, Holland's knob enlightening
West Asia company, every 100ml 4g in protein, fat 3.89g, carbohydrate 12.3g): 40 examples, male 20 examples, female 20 example；Age
(40 ± 8.4) year；(2) experimental group (the Elental group of embodiment 2 preparation): 40 examples, male 24 examples, female 16 example, age (39.8
± 9.1) year, the age of two groups of patients, sex, AD, APACHEII scoring there are no significant difference when being admitted to hospital.
4, the method for nutritional support: two groups of Nasal cavity intestinal tubes all using band seal wire in postoperative 48 hours, length 120cm,
Start nasal feeding nutrition agent, by two groups of nutrient suction syringes, be slowly injected in 5～10min in nasal feeding feeding tube, typically
400mL every time, interval time is with 3h, every day 4 times, the zero difference in terms of position angle when feeding.
5, monitoring index
(1) clinical observation: observe patient and early postoperation is accepted the toleration of EN support, including nausea and vomiting,
Abdominal distention, constipation and diarrhoea etc..With defecation frequency every day more than 3 times, soft stools, shapeless for diarrhoea.
(2) Biochemistry test: include evaluation of nutrition Indexs measure (serum albumin, prealbumin, transferrins),
Hepatic and renal function, gathers peripheric venous blood detection on an empty stomach in early morning for the 1st, 4,7 days after entering ICU.
(3) immune index detection: 1,4,7 days survey serum IgG (g/L), IgM (g/L), IgA (g/L), IL-6 (pg/ml),
CRP (mg/l), total lymphocyte count (× 109)。
(4) average ICU length of stay.
6, testing result
1 liang of table group patient enters mono-week interior mean albumin level (g/L) of ICU and compares
| Group | 1st day | 4th day | 7th day |
| Test group | 21.9 | 37.6 | 40.3 |
| Matched group | 22.4 | 22.8 | 25.6 |
Entering mean albumin level in ICU mono-week by two groups of patients to compare and learn from table 1, two groups of patients give nutrition and prop up
The albumin level held in rear serum is improved, but gives the test group relatively matched group of embodiment 2 nutrient, in serum
Albumin level improves speed faster.
2 liang of table group patient enters mono-week interior average prealbumin level (g/L) of ICU and compares
| Group | 1st day | 4th day | 7th day |
| Test group | 0.24 | 0.27 | 0.31 |
| Matched group | 0.22 | 0.22 | 0.23 |
In entering ICU mono-week by two groups of patients, average prealbumin level compares and learns from table 2, and two groups of patients give nutrition
After support, prealbumin level is improved, but gives the test group relatively matched group of embodiment 2 nutrient, prealbumin level
Ascendant trend becomes apparent from.
3 liang of table group patient enters mono-week interior average Transferrin (g/L) of ICU and compares
| Group | 1st day | 4th day | 7th day |
| Test group | 1.35 | 1.42 | 1.51 |
| Matched group | 1.34 | 1.35 | 1.36 |
In entering ICU mono-week by two groups of patients, average Transferrin compares and learns from table 3, and two groups of patients give nutrition
After support, transferrin content is improved, but gives the test group relatively matched group of embodiment 2 nutrient, transferrin content
Increase becomes apparent from.
4 liang of table group patient enters mono-week interior immune indexes average level of ICU and compares
From table 4 it will be apparent that, two groups of patients enter ICU and rise for the 4th day, and body's immunity is all constantly recovering, immune globulin
Bai Ru: IgG, IgA, IgM level constantly rises, and inflammatory factor (IL-6 and CRP) level constantly reduces, but with matched group phase
Ratio, the test group patient giving embodiment 2 nutrient compares, and immunologic function resume speed significantly improves.
After giving nutritional support to two groups of patients entering ICU, carry out clinical observation, have 5 examples (matched group 5 example, test
Organize 0 example) occur existing abdominal distention, suffer from abdominal pain, the digestive tract side reaction such as vomiting, in terms of diarrhoea and stool discharge number of times, have (the comparison of 3 examples
Organize 3 examples, test group 0 example) diarrhoea occurs, draw pasty state loose stool number of times more (3-5 time).According to the record average ICU of test group patient
Length of stay is 4 days, matched group patient average ICU length of stay 7 days.
Claims (2)
1. serious symptom and the postoperative Elental through nasointestinal tube row, it is characterised in that be made up of the component of following parts by weight: people
Ginseng flower extracting solution 30-70 part, Herba bromi japonici bran corium farinosum 5-15 part, breaking wall of chlorella powder 10-20 part, Hericium Erinaceus Polysaccharide 5-20 part, Phellinus igniarius (L. ex Fr.) Quel.
Polysaccharide 5-20 part, vegetable oil 15-30 part, starch sodium octenyl succinate 1-3 part, carrageenan 1-3 part；Described vegetable oil be by
According to Fructrs Hippophae seed oil: almond oil: Oleum Camelliae: walnut oil=1:2:2:1 weight ratio mixes.
Serious symptom the most according to claim 1 and the preparation method of the postoperative Elental through nasointestinal tube row, its feature exists
In, specifically include following steps:
1., select fresh, free from admixture, natural in color Flos Ginseng, the sodium chloride solution that concentration is 2mol/l soak 60min,
It is dried to constant weight in 40 DEG C of environment after taking-up, pulverized 80 mesh sieves, decoct after soaking 3min with 70 ± 5 DEG C of hot distilled waters
30min, obtains Flos Ginseng's extracting solution, standby；
2., by bran of Fagopyrum esculentum Moench through micronizing, cross 200 mesh sieves, obtain Herba bromi japonici bran corium farinosum, standby；
3., take hericium erinaceus fruiting body, be cut into the thick thin slice of 1cm, be dried to constant weight in 50 DEG C of environment, add Hericium erinaceus (Bull. Ex Fr.) Pers. and be dried
Product weight 2.5% cellulase solution, puts in 45 DEG C of calorstats, and insulation reaction 45min puts into 80 DEG C of baking ovens after then taking out
In be dried, crushed after being dried crosses 200 mesh sieves, adds 90 DEG C of hot water constant temperatures extraction 3h of its dry powder weight 2 times, centrifuging and taking supernatant
Liquid, lyophilization, obtain Hericium Erinaceus Polysaccharide, standby；
4., Herba bromi japonici bran corium farinosum, breaking wall of chlorella powder, Hericium Erinaceus Polysaccharide and phellin polysaccharides are added sequentially to Flos Ginseng's extracting solution
In, high speed shear under the rotating speed of 3000r/min, after raw material is completely dissolved, add the octenyl of parts by weight described in formula
Succinic acid starch sodium, continues to shear 5min, adds vegetable oil and the carrageenan of described parts by weight, continues to shear 45min,
To colostrum；Then, under the pressure of 800bar, with high pressure homogenizer homogenizing 3 times, Elental is obtained.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1961746A (en) * | 2006-11-28 | 2007-05-16 | 中国科学院南海海洋研究所 | Clinical enternal nutrition made from halobios |
| CN104207144A (en) * | 2014-09-26 | 2014-12-17 | 上海励成营养产品科技股份有限公司 | High-energy enteral nutrition multi polymerizer |
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|---|---|---|---|---|
| CN1961746A (en) * | 2006-11-28 | 2007-05-16 | 中国科学院南海海洋研究所 | Clinical enternal nutrition made from halobios |
| CN104207144A (en) * | 2014-09-26 | 2014-12-17 | 上海励成营养产品科技股份有限公司 | High-energy enteral nutrition multi polymerizer |
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