CN102224931B - Composition assisting in reduction of blood sugar - Google Patents
Composition assisting in reduction of blood sugar Download PDFInfo
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- CN102224931B CN102224931B CN2011101461247A CN201110146124A CN102224931B CN 102224931 B CN102224931 B CN 102224931B CN 2011101461247 A CN2011101461247 A CN 2011101461247A CN 201110146124 A CN201110146124 A CN 201110146124A CN 102224931 B CN102224931 B CN 102224931B
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Abstract
The invention provides a composition assisting in reduction of blood sugar, belonging to the field of food and healthcare food. The composition is prepared from the following raw materials in parts by weight: 5-30 parts of aloe powder containing 2-4% of aloe and chromone mixture, 5-30 parts of bitter gourd powder, 1-10 parts of fragrant solomonseal rhizome powder, 1-10 parts of onion powder and 1-10 parts of konjac powder. According to the invention, the raw materials are simple and easily available, all come from vegetables, have high safety and are widely accepted by the patients; and the product prepared therefrom is cheap and perfect and easily accepted by the patients.
Description
Technical field
The invention belongs to food and field of health care food, but be specifically related to a kind of composition of assisting in reducing blood sugar, it is combined by the aloe powder that contains 2～4% aloe chromones, balsam pear powder, radix polygonati officinalis powder, onion powder, konjaku flour.
Background technology
Diabetes (diabetes) are by inherent cause, immunologic function disorder, infected by microbes and toxin thereof, the free radical toxin, the various virulence factors of mental element etc. act on body and cause hypoinsulinism, insulin resistance etc. and the sugar that causes, protein, fat, a series of metabolic disorder syndromes such as power and water Xie Zhi, clinically take hyperglycaemia as main feature, diuresis can appear in model case, many drinks, many foods, the performance such as become thin, i.e. " three-many-one-little " symptom, diabetes (blood sugar) cause diabetic complication in case control bad meeting, cause kidney, eye, the depleted pathology at the positions such as foot, and can't cure.Needs of patients periodic monitoring blood sugar level, in time control is in case the generation of complication.
The diabetes patient need to adhere to the standard treatment for a long time, comprising: keep on a diet, adhere to the moderate exercise exercise, the rational use of medicines.In the rational use of medicines, can also eat some foods with effect of lowering blood sugar in order to auxiliary hyperglycemic, keep the stable of blood sugar level, improve life in patients.
Although the health food of adjuvant therapy of diabetes is more at present, majority contains Chinese medicine or chemical raw material, thereby in auxiliary antilipemic, also can bring certain side effect, and the preparation method is complicated, and cost is high.Such as the Patent Application Publication of application number 200910147621.1 a kind of health food with auxiliary hyperglycemic, auxiliary lipid-lowering function, it mainly is to be prepared from according to a certain weight ratio by propolis, Bitter Melon P.E, ginkgo biloba p.e, chromium picolinate, olive oil, wherein, chromium picolinate is exactly a kind of chemical addition agent.And for example application number 201010210098.5 discloses a kind of health food with auxiliary hyperglycemic function, the component that comprises following percentage by weight: 40～55% Astragalus Root P.E, 15～30% green-tea extract, 10～25% gadol extract, 5～20% American ginseng extract, 5～15% Cr-enriched yeast, wherein, the Radix Astragali, rhodiola root, American Ginseng are Chinese medicine material.
The present invention adopts food aloe, balsam pear, radix polygonati officinalis, onion, konjaku to combine, aloe bitter, cold wherein, cool liver and clearing heat.Bitter gourd flavored is extremely bitter, contains the compositions such as Charantin, serotonin, glutamic acid, alanine and vitamin B1.Radix polygonati officinalis has yin-nourishing, moisturizes relieving restlessness, the effect of quenching the thirst.Onion flavor is sweet, hot, and slightly warm in nature is close with green onion, garlic nature and flavor, has stomach invigorating, improves a poor appetite, the effect of promoting the circulation of qi in wide.Konjaku is a kind of low calorie, high-cellulose food, and because its molecular weight is large, viscosity is high, in enteron aisle, drain slowly, thus the absorption of energy delay glucose, and effectively reduce the postprandial blood sugar rising.
Summary of the invention
The object of the present invention is to provide a kind of preparation method and purposes of composition and preparation thereof of assisting in reducing blood sugar, the raw material of said composition are vegetables, and its source is simple and easy to, and safe, cost is low, has no side effect.
The concrete technical scheme that the present invention adopts is:
A kind of composition of assisting in reducing blood sugar is characterized in that the raw material that is comprised of following weight parts is formulated:
1～10 part of 1～10 part in 5～30 parts of 5～30 parts of aloe powders, balsam pear powders, radix polygonati officinalis powder, the onion powder, 1～10 part of the konjaku flour that contain 2 ~ 4% aloe chromone mixtures.
The best proportioning of the present composition is: 2 parts of 2 parts in 20 parts of 10 parts of aloe powders, balsam pear powders, radix polygonati officinalis powder, the onion powders, 2 parts of the konjaku flours that contain 2-4% aloe chromone mixture.
Described aloe powder, balsam pear powder, radix polygonati officinalis powder, onion powder, konjaku flour all adopt the conventional method preparation and get.
The preparation method of present composition capsule is: get 2-4% aloe chromone mixture aloe powder 1g, balsam pear powder 2g, radix polygonati officinalis powder 0.2g, onion powder 0.2g, konjaku flour 0.2g, mix, be distributed into capsule, every dress 0.3g.
The eating method of present composition capsule is: oral, and every day 3 times, each 4.
Advantage of the present invention: raw material sources is simple and easy to, and material therefor all picks up from the vegetables material, and is safe, and patient's acceptance is strong, and the product of made is good and cheap, and the patient is acceptant.
The specific embodiment
Below in conjunction with embodiment foregoing of the present invention is described in further detail again, but this should be interpreted as technical solution of the present invention only limits to following examples.
Embodiment 1 pharmacodynamics test
1, summary: this experiment is carried out the diabetes modeling with alloxan to mouse, choose the mouse of modeling success as animal subject, each is organized test sample and gives mouse with 0.6g, 1.2g, 2.4g/kg gavage, respectively at 10,20,30 days measuring blood sugar of blood extracting after the administration, and the body weight of the 30th day each treated animal compared.The result shows that this patent composition has certain auxiliary hyperglycemic effect, and can improve many drinks, the diuresis of diabetic mice and the symptom that loses weight.
2, test objective: observe this composition oral gastric infusion to the impact of model mice blood sugar.
3, test material
3.1 tested medicine:
Test sample A(this patent composition): capsule, 3.6g/ days.Think special medicine Co., Ltd by power lot number is provided: 110201.Before use content is for experiment with the liquid that distilled water is mixed with 0.06g, 0.12g, 0.18g/ml.
Test sample B[aloe powder (2-4% aloe chromone mixture)]: 1.0g/ days.Think special medicine Co., Ltd by power lot number is provided: 110201.Before use content is for experiment with the liquid that distilled water is mixed with 0.017g, 0.033g, 0.048g/ml.
Test sample C: get balsam pear powder 2g, radix polygonati officinalis powder 0.2g, onion powder 0.2g, konjaku flour 0.2g, mix 2.6g/ days.Think special medicine Co., Ltd by power lot number is provided: 110201.Before use content is for experiment with the liquid that distilled water is mixed with 0.043g, 0.087g, 0.129g/ml.
3.2 animal used as test
Healthy Kunming mouse, body weight 18～22g, male and female half and half, Chengdu reaches large bio tech ltd to be provided, regular grade animal, animal credit number SCXK(river) 2006-24.
3.3 reagent and instrument
Alloxan (alloxan): Fluka company; Glucose assays kit: Shanghai Rong Sheng Biology Pharmacy Co., Ltd.
3.4 feed
Full price mouse pellet: provided by Sichuan Province animal used as test Professional Committee plant.
3.5 experimental condition
Breeding observing room temperature: 22～24 ℃.Relative humidity: 60%～70%.
4, method and result
4.1 the foundation of diabetes animal model
Small white mouse is bought back after adaptability feeds a week, get at random 10 and be blank group (Normal control group, NC), all the other all carry out the diabetes modeling by the 200mg/kg body weight to mouse peritoneal injection alloxan, fasting 12h but can't help water before the injection, behind the modeling 72h, make mouse fasting 8h posterior orbit get blood and carry out the blood sugar prediction, the mouse of selecting blood glucose value to be higher than 11.1mmol/L is tested.Animal pattern possesses the type i diabetes feature.
4.2 the processing of animal used as test
Get 100 of the diabetic mices of modeling success, press the blood sugar random packet, respectively as model group (Diabetic control group, DC), the high, medium and low dosage group of test sample A, the high, medium and low dosage group of test sample B, the high, medium and low dosage group of test sample C, each is organized gavage dosage and is respectively: NC group and DC organize 0.2ml/d gavage physiological saline; The high, medium and low dosage group of test sample is the liquid 0.2ml/d of gavage 0.24g, 0.12g, 0.06g/ml respectively.Gavage cycle 30d.In the time of gavage, observe nutrition condition, the changes of weight of respectively organizing mouse.Get blood in administration the 10th, 20 days thorn eye sockets, measure fasting blood sugar.In last administration 1h, fasting 12h, the scale body weight is got tail vein and is got blood plasma after centrifugal and survey blood sugar.
4.3 results and analysis
4.3.1 test sample is on the impact of diabetic mice ordinary circumstance
The NC group: the animal state of mind is good, is quick on the draw, and hair color is smooth, shinny, and diet is normal, and stool and urine is normal.
DC group: animal obviously becomes thin, and spirit is more dispirited, and wherein many colour blindness occurs, slow in reacting, and hair color is dim, matt, occur " three-many-one-little phenomenon ", namely many drink, many foods, diuresis, lose weight.
The test sample group: animal is compared with the DC group, and the state of mind is better, and " three-many-one-little phenomenon " is than alleviating.
4.3.2 test sample is on the impact of blood glucose in diabetic mice
As can be seen from Table 1, compare (0 day) with blank group (NC group), model group (DC group), test sample A, B, C group blood glucose value have utmost point significant difference (P＜0.01), and the modeling success is described.Compare with model group DC group, administration the 10th day, test sample A high dose group can obviously reduce blood sugar (p＜0.05), and other administration groups only have hypoglycemic trend; Administration the 20th day, test sample A high dose group can extremely significantly reduce blood sugar (p＜0.01), among the test sample A, low dose group, the middle and high dosage group of test sample B, C can obviously reduce blood sugar (P＜0.05); Administration the 30th day, test sample A high dose group can extremely significantly reduce blood sugar (p＜0.01), among the test sample A, low dose group and the high, medium and low dosage group of test sample B, C can obviously reduce blood sugar (p＜0.05).Illustrate that test sample A, B, C all can obviously reduce the blood glucose value of diabetic mice, have hypoglycemic activity, test sample A effect is better than other and respectively organizes the test sample group.
Table 1 test sample is on the impact of blood glucose in diabetic mice
Annotate: compare with the blank group (0 day),
△ △ P＜0.01; Compare with model group (10 days, 20 days, 30 days),
*P＜0.05,
*P＜0.01.
Test sample is on the impact of diabetic mice body weight
As can be seen from Table 2, compare with blank group (NC group), there were significant differences for test sample high dose group body weight, and other each groups have utmost point significant difference; Compare with model group (DC group), each dosage group body weight of test sample has utmost point significant difference.Illustrate and respectively organize the be improved effect of diabetic mice body weight of test sample, test sample A high dose group is better than other each groups.
Table 2 test sample is on the impact (the 30th day) of each group Mouse Weight
Annotate: compare with the blank group,
△ △ P＜0.01; Compare with model group,
*P＜0.05,
*P＜0.01.
5, conclusion
This experiment has adopted chemical damage medicine alloxan that mouse is carried out the diabetes modeling, and alloxan can selectively be absorbed by beta Cell of islet, and then trigger cell is downright bad, thereby reduces the source of insulin and blood sugar is raise.Many drinks have appearred in mouse, the symptom of eating more, become thin, and blood sugar also obviously raises, and has successfully set up diabetes model.
After to tissue of experimental diabetic mice gavage test sample 30d, the basic, normal, high dosage group of test sample all shows preferably hypoglycemic activity, and presents certain dose-effect relationship.
Above-mentioned result of the test shows, test sample A(this patent composition) have obvious hypoglycemic activity, its effect is better than test sample B, C group.The explanation composition blood sugar decreasing effect that adopts aloe powder (2-4% aloe chromone mixture) and balsam pear powder, radix polygonati officinalis powder, onion powder g, konjaku flour to form is better than the mixture of single aloe powder (2-4% aloe chromone mixture) or balsam pear powder, radix polygonati officinalis powder, onion powder, konjaku flour composition thus.
Embodiment 2 formula tests
A kind of composition of assisting in reducing blood sugar is characterized in that the raw material that is comprised of following weight parts is formulated:
1 part of 5 parts in 10 parts of 5 parts of aloe powders, balsam pear powders, radix polygonati officinalis powder, the onion powder, 6 parts of the konjaku flours that contain 2 ~ 4% aloe chromone mixtures.
Embodiment 3 formula tests
A kind of composition of assisting in reducing blood sugar is characterized in that the raw material that is comprised of following weight parts is formulated:
5 parts of 10 parts in 20 parts of 30 parts of aloe powders, balsam pear powders, radix polygonati officinalis powder, the onion powders, 10 parts of the konjaku flours that contain 2 ~ 4% aloe chromone mixtures.
Embodiment 4 formula tests
A kind of composition of assisting in reducing blood sugar is characterized in that the raw material that is comprised of following weight parts is formulated:
10 parts of 1 part in 5 parts of 10 parts of aloe powders, balsam pear powders, radix polygonati officinalis powder, the onion powders, 3 parts of the konjaku flours that contain 2 ~ 4% aloe chromone mixtures.
Embodiment 5 formula tests
A kind of composition of assisting in reducing blood sugar is characterized in that the raw material that is comprised of following weight parts is formulated:
6 parts of 3 parts in 30 parts of 20 parts of aloe powders, balsam pear powders, radix polygonati officinalis powder, the onion powders, 1 part of the konjaku flour that contain 2 ~ 4% aloe chromone mixtures.
Embodiment 6 formula tests
A kind of composition of assisting in reducing blood sugar is characterized in that the raw material that is comprised of following weight parts is formulated:
2 parts of 2 parts in 20 parts of 10 parts of aloe powders, balsam pear powders, radix polygonati officinalis powder, the onion powders, 2 parts of the konjaku flours that contain 2-4% aloe chromone mixture.
Claims (3)
1. the composition capsule of an assisting in reducing blood sugar is characterized in that the raw material that is comprised of following weight parts is formulated:
1～10 part of 1～10 part in 5～30 parts of 5～30 parts of aloe powders, balsam pear powders, radix polygonati officinalis powder, the onion powder, 1～10 part of the konjaku flour that contain 2～4% aloe chromone mixtures.
2. the composition capsule of assisting in reducing blood sugar as claimed in claim 1 is characterized in that the raw material that is comprised of following weight parts is formulated:
2 parts of 2 parts in 20 parts of 10 parts of aloe powders, balsam pear powders, radix polygonati officinalis powder, the onion powders, 2 parts of the konjaku flours that contain 2-4% aloe chromone mixture.
3. the composition capsule of assisting in reducing blood sugar as claimed in claim 1, it is characterized in that the preparation method is: get 2-4% aloe chromone mixture aloe powder 1g, balsam pear powder 2g, radix polygonati officinalis powder 0.2g, onion powder 0.2g, konjaku flour 0.2g, mix, be distributed into capsule, every dress 0.3g.
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| CN2011101461247A CN102224931B (en) | 2011-06-01 | 2011-06-01 | Composition assisting in reduction of blood sugar |
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| CN2011101461247A CN102224931B (en) | 2011-06-01 | 2011-06-01 | Composition assisting in reduction of blood sugar |
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| CN102224931B true CN102224931B (en) | 2013-03-06 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102697051A (en) * | 2012-06-15 | 2012-10-03 | 江苏绿茵生物科技有限公司 | Compound bitter gourd powder for decreasing blood sugar |
| CN104757376A (en) * | 2015-03-14 | 2015-07-08 | 宁波高新区苗姑养生科技有限公司 | Life-nourishing and health-care rice powder suitable and special for diabetics and a preparation method thereof |
| CN110870516A (en) * | 2018-09-03 | 2020-03-10 | 季松楼 | Functional beverage for diabetic patients |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095805A (en) * | 2007-06-29 | 2008-01-02 | 李美瑛 | Medicine made by onion and aloe and method for preparing the same |
| CN101406642A (en) * | 2008-11-28 | 2009-04-15 | 魏玉玲 | Antihypelipidemic compound formulation |
| CN101450166A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composition with blood-sugar function and preparation method thereof |
| CN101869288A (en) * | 2009-04-21 | 2010-10-27 | 姜传书 | Compound aloe blood sugar reduction coating rice |
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- 2011-06-01 CN CN2011101461247A patent/CN102224931B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095805A (en) * | 2007-06-29 | 2008-01-02 | 李美瑛 | Medicine made by onion and aloe and method for preparing the same |
| CN101450166A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Traditional Chinese medicine composition with blood-sugar function and preparation method thereof |
| CN101406642A (en) * | 2008-11-28 | 2009-04-15 | 魏玉玲 | Antihypelipidemic compound formulation |
| CN101869288A (en) * | 2009-04-21 | 2010-10-27 | 姜传书 | Compound aloe blood sugar reduction coating rice |
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