CN104887760A - Ganoderma spore powder wine and preparation method thereof - Google Patents
Ganoderma spore powder wine and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a ganoderma spore powder wine for treating diabetes and improving immunity and a preparation method thereof. The ganoderma spore powder wine is prepared from the following raw materials in parts by weight: A, 1-3 parts of ganoderma spore powder; B, 1-3 parts of fructus swietenia macrophylla; and C, 8-15 parts of distilled liquor with the alcohol degree of 40-65. The preparation method of the ganoderma spore powder wine comprises the following steps: (1) weighing the ganoderma spore powder, the fructus swietenia macrophylla and the distilled liquor for later use; (2) crushing the fructus swietenia macrophylla, and putting the ganoderma spore powder, the fructus swietenia macrophylla powder and the distilled liquor into a container; (3) treating the raw materials for 30 minutes to 1 hour by using an ultrasonic cell crusher at 20-40 DEG C; and (4) soaking continuously for 3-6 hours. The ganoderma spore powder wine not only has an effect of treating diabetes, but also has an effect of improving the immunity of a diabetic.
Description
Technical field
The present invention relates to a kind of herbal wine, particularly a kind of Ganoderma spore powder wine for the treatment of diabetes and improving immunity.
Background technology
Alcoholic strength temperature, acrid in the mouth and bitter sweet, there is warm promoting blood circulation, warm the intestines and stomach, dispersing wind and cold of dispelling, rouse oneself yang-energy, the effects such as allaying tiredness, have the saying of " length of hundred medicines ", now there are some researches show, the main component ethanol of wine is a kind of fabulous semi-polarity organic solvent, and the Multiple components of Chinese medicine is as all more soluble in ethanol in alkaloid, salt, tannin, oils, organic acid, resin and pigment etc.; Meanwhile, ethanol has good penetrance, is easy to enter medical material histiocyte, play dissolution, carry out replacing or spreading, be conducive to the raising speed of invading out and effect, simultaneously, ethanol also has antisepsis, the hydrolysis of medicine can be delayed, strengthen the stability of medicament, Chinese medicine and wine " are melted " and is integrated, the medicated wine that the property of medicine is stable can be formed, extensively praise highly by people.
Diabetes are because insulin is absolute or relative hyposecretion causes, for commonly encountered diseases, frequently-occurring disease, year number of the infected more than 9,000,000, diabetes have the tendency of rejuvenation and extension now, the second killer in modern diseases, it is only second to cancer to the harm of human body, cause serious body and mind infringement and burden on society, in China, the sixties is to the seventies, the living standard of the people is lower, staple food grain distributes according to plan, the document-based supply of Chicken and fish meat egg, the sickness rate of diabetes was extremely low at that time, after reform and opening-up, the living standard of the people improves constantly, staple food grain and non-staple food are all very abundant, additional irrational dietary structure, cause people's body overnutrition, endocrine disturbance, seriously induce diabetes, the morbidity situation of diabetes has become a global problem, in decades, countries in the world have carried out long-term and unremitting research and development one after another, have developed a lot of medicines, but do not have substantial breakthrough all the time due to the pathology to diabetes, etiological study.
Now there are some researches show: 90% diabetics hypoimmunity, be easy to sick or can not cure for a long time, renal failure is one of common complication of diabetes, is also the major reason causing diabetics death.Pathogenesis of diabetes mellitus is complicated, volleys relevant as the factor such as carbohydrate metabolism disturbance, infective agent all lowly counts disease with each functioning immune power of health.Recently research shows, hypoimmunity will make conditions of patients increase the weight of.Therefore, diabetics, while control blood glucose, improves immunity and also seems abnormal important.
Existing Chinese crude drug, particularly Ganoderma spore powder, to sky fruit etc., as adopted alcohol-pickled general technology, its soak time is mostly more than 15 days, production time is longer, so will cause in workshop and hoard medicated wine storing unit in a large number, take a large amount of spaces, meanwhile, medicinal ingredient dissolution rate is also relatively low.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of Ganoderma spore powder wine can treated diabetes and improve immunity.
Meanwhile, present invention also offers a kind of preparation method that can overcome long this Ganoderma spore powder of the preparation wine of traditional handicraft soak time.
For solving the problems of the technologies described above, content of the present invention is as follows:
A kind of Ganoderma spore powder wine, is characterized in that, be made up of the raw material of following weight portion:
A: Ganoderma spore powder, 1 ~ 3 weight portion;
B: Xiang Tianguo, 1 ~ 3 weight portion;
C: the Spirit of alcoholic strength 40 ~ 65,8 ~ 15 weight portions.
Preferred version is as follows:
A: Ganoderma spore powder, 2 weight portions;
B: Xiang Tianguo, 1 weight portion;
C: the alcoholic strength of Spirit is 52 degree, 9 weight portions.
The preparation method of described Ganoderma spore powder wine, is characterized in that, comprise the following steps:
(1) Ganoderma spore powder, Xiang Tianguo and Spirit have been weighed for subsequent use;
(2) will pulverize to sky fruit, by Ganoderma spore powder, be placed in container to sky fruit powder and Spirit;
(3) temperature is 20 ~ 40 DEG C, with ultrasonic cell disruption instrument to Feedstock treating 30min to 1h;
(4) immersion 3 ~ 6 hours is continued.
Preferred preparation method is: described Spirit is 100-4000 milliliter, and the frequency of ultrasonic cell disruption instrument is 25 ~ 35KHz, power is 500 ~ 1000W.
More preferred preparation method is: described Spirit is 100-1000 milliliter, and described ultrasonic cell disruption instrument frequency is 30KHz, power is 800W, and the processing time is 30 minutes.
Ganoderma spore powder is the seed of the extremely small avette sexual cell that shoots out and Ganoderma of being hit by a bullet from Ganoderma lamella, each Ganoderma spore only has 4-6 micron, it is living organisms, outer by hard chitin fiber element surround, human body is difficult to fully absorb, and be more suitable for human body the intestines and stomach after breaking cellular wall and directly absorb, it has condensed the elite of Ganoderma, there is whole hereditary material and the health-care effect of Ganoderma, Ganoderma sweet-bitter flavor, property is put down, GUIXIN, lung, liver, spleen channel, can tranquilizing by nourishing the heart, quiet lung QI invigorating, regulating the flow of QI to dissipate blood stasis, and liver nourishing spleen invigorating, cures mainly asthenia weak, spiritlessness and weakness, palpitation and insomnia, and the head swoons, and chronic cough is panted, and lack of appetite is indigestion and loss of appetite, and Ganoderma has abundant nutritional labeling, containing ganoderan, Ganoderma polypeptide, Ganodenic acid, 16 seed amino acids, alkaloid, organic acid etc., also containing a large amount of trace element, and containing the nutritional labeling abundanter than parent in Ganoderma spore, now there are some researches show, Ganoderma spore has anticancer, antiinflammatory, protect the liver, blood fat reducing, blood sugar lowering, enhancing immunity function and antivirus action, its nutritional labeling mainly contained is 1) ganoderan: can strengthen immune function, prevention and therapy tumor and cancer, reduce blood pressure, and the generation of prevention cardiovascular diseases, stimulates the secretion of insulin, reduces blood sugar concentration, 2) triterpenes Ganodenic acid: improve microcirculation, reduces cholesterol, avoids sclerosis of blood vessels, strengthens liver, spleen and gastrointestinal function, perfects Alimentary running, 3) ribosidoadenine: suppress platelet aggregation, prevent thrombosis.
, convergence bitter, puckery, cool in nature, antipyretic to sky fruity, kernel is strong, and its seed cures mainly diabetes, hypertension.With the best that is produced from Solomon Islands, because the composition to sky fruit of various places differs greatly, so the present invention adopts former treasure to sky fruit, it is described as " after plant ", its healthy benefits is passed on from generation to generation already in Solomon Islands, the history that local Solomon Islands resident takes to sky fruit has exceeded thousand, be used for the treatment of diabetes, hypertension, anaphylactic disease, endocrine disturbance etc., according to statistics, the diabetes of locals, hypertensive sickness rate far below other parts of the world, this and its eat for a long time to sky fruit closely related.Modern study shows, Xiang Tianguo contains three large active substances, be respectively Saponin, flavonoid and isoflavone: Saponin has reduction blood glucose and improves symptom, reduce cholesterol, blood fat reducing, reduce platelet aggregation, avoid the formation of thrombosis, improve coagulation status and avoid myocardial infarction, strengthen premunition and promote muscle power, improving the function of immunity; Flavonoid has blood circulation promoting, and prevention cerebrovascular occlusion causes apoplexy, and prevention Alzheimer can reduce the accumulation of fat in blood vessel wall, can improve or reduce the function of blood middle cholesterol content; Isoflavone is a kind of natural plants estrogen, can nurse one's health female pathology clock, menopause syndrome of releiving, and prevention skeleton bulking disease, has the function of endocrine regulation.
The present invention organically combines by Ganoderma spore with to the function of sky fruit; adopt the technique of ultrasonic disruption cell; can greatly improve the utilization rate of Ganoderma spore powder and Xiang Tianguo; in addition; this preparation method whole process adopts room temperature; effectively can protect the effective ingredient of Chinese crude drug, prevent high temperature to the destruction of medicinal ingredient.
Ultrasonic extraction utilizes hyperacoustic cavitation, mechanism, heat effect etc. to increase molecular motion of material frequency and speed, increases solvent penetration power, thus improve the method for target component leaching rate.It has save time, energy-conservation, extraction efficiency advantages of higher, be one new method for extracting fast and efficiently, and extract in without heating process, the ingredient structure that heating factors can be avoided to cause changes, and can be used for the extraction of heat-sensitive ingredients.Also have an advantage, less demanding to temperature of ultrasonic extraction, can extract at normal temperatures, does not need heating, high temperature so can be avoided the destruction of Chinese crude drug medicinal ingredient.
Ganoderma spore powder with to sky fruit each have their own drug effect, they two not only separate but also interrelated, existing control blood glucose, glucose in urine, can improve again the effect of diabetics immunity, the present invention borrows capacity for liquor to declare smooth mechanism of qi, starts QI-blood circulation, the efficacy of a drug is directly guided to whole body body efficiently, wine is penis, its property movability, hair growth promoting is quick, is the medicine of tying-in.The present invention's wine used is high concentration Spirit, can cover the pole bitter taste to sky fruit, and its positive is stronger, can play a multiplier effect.
Instructions of taking: every day twice sooner or later, one time 10 milliliters, within three months, be a course for the treatment of, generally, be used in conjunction 5 courses for the treatment of.
This Ganoderma spore powder wine not only has effect for the treatment of diabetes, meanwhile, also has the effect of the immunity improving diabetics.
Preparation method of the present invention, not only processing time is consuming time shortens greatly, and medicinal ingredient dissolution rate is also higher.
Detailed description of the invention
The present invention is set forth further below in conjunction with embodiment:
Embodiment 1
Take Ganoderma spore powder 20 grams, to sky fruit 10 grams, 52 degree of Spirits 90 grams are for subsequent use;
To pulverize to sky fruit pulverizer, powder particle size is 50 orders, by Ganoderma spore powder, is placed in terrine to sky fruit powder and Spirit;
25 degrees Celsius, with ultrasonic cell disruption instrument under 30KHz, 800W, to Feedstock treating 30min;
Then, continue immersion and get final product subpackage in 5 hours, due to using method of the present invention be one time 10 milliliters, so, adopt volume to be 10 milliliters bottled, conveniently drink.
Embodiment 2
Take Ganoderma spore powder 10 grams, to sky fruit 30 grams, 55 degree of Spirits 150 grams are for subsequent use;
To pulverize to sky fruit pulverizer, powder particle size is 50 orders, by Ganoderma spore powder, is placed in terrine to sky fruit powder and Spirit;
25 degrees Celsius, with ultrasonic cell disruption instrument under 35KHz, 800W, to Feedstock treating 45min;
Then, continue immersion and get final product subpackage in 4 hours, due to using method of the present invention be one time 10 milliliters, so, adopt volume to be 10 milliliters bottled, conveniently drink.
Embodiment 3
Take Ganoderma spore powder 20 grams, to sky fruit 20 grams, 50 degree of Spirits 110 grams are for subsequent use;
To pulverize to sky fruit pulverizer, powder particle size is 50 orders, by Ganoderma spore powder, is placed in terrine to sky fruit powder and Spirit;
25 degrees Celsius, with ultrasonic cell disruption instrument under 30KHz, 1000W, to Feedstock treating 50min;
Then, continue immersion and get final product subpackage in 5 hours, due to using method of the present invention be one time 10 milliliters, so, adopt volume to be 10 milliliters bottled, conveniently drink.
Before subpackage of the present invention, do not filter, in the sub-bottling of 10 milliliters, will have a small amount of medicinal powder like this, this is conducive to Chinese crude drug and is distilled wine and further invades bubble, has the custom of edible medicinal material, also edible if any patient.
Certainly, this Ganoderma spore powder wine also can filter before subpackage, filtering medicinal residues.
Generally, the immersion of medicated wine needs more than 10 days, and this preparation technology adopts ultrasonic disruption technology, and preparation process is shortened to several hours, can promote speed of production greatly, for enterprise brings productivity effect.
In addition, adopt ultrasonic disruption technology, can obtain higher cell crashing ratio, in medicated wine, pharmaceutical ingredient content is higher, and therapeutic effect is better.
Clinical treatment embodiment:
Choose 180 diabeticss and carry out Clinical Treatment Test, wherein, 60 severe patients, 60 moderate patients, 60 patients with mild, drink the medicated wine obtained by embodiment 1 every day, twice sooner or later, each 10 milliliters, be used in conjunction 5 courses for the treatment of, choose diabetics standard as follows:
Patients with mild: fasting glucose and after the meal 3h glycemic peaks difference are less than 5mmol/L, and insulin secretion is normal or not enough, C-peptide release function is in normal range;
Moderate patient: fasting glucose and after the meal 3h peak difference at 5-10mmol/L, insulin releasing at 1h, 2h after the meal lower than normal value 1/3, C-peptide release function in normal range;
Severe patient: fasting glucose and after the meal 3h glycemic peaks at more than 10mmol/L, insulin releasing 1h, 2h after the meal lower than normal value 2/3 or on an empty stomach and after the meal 1h, 2h, 3h all low C-peptide release function slightly below.
Test 1: the therapeutic effect of diabetic condition observing diabetics before and after treatment, the record state of an illness is also analyzed, and the therapeutic effect of diabetes is divided into symptom management, effective, effective, invalid, result is as table 1;
The judgment criteria of above-mentioned curative effect is:
Symptom management: clinical symptom disappearance, carbohydrate tolerance, insulin releasing, blood glucose and glucose in urine are all normal;
Effective: clinical symptoms major part disappears, and fasting glucose is normal, 3 hours blood glucoses still higher peak difference 3-5mmol/L after the meal, and insulin and C-peptide are released in normal range;
Effective: clinical symptom relief, fasting glucose and after the meal 3 hours blood glucose value differences, comparatively decline 2-3mmol/L before treatment;
Invalid: clinical symptoms does not change, every laboratory indexes does not change.
Table 1
Table 1 data analysis: this herbal wine is 83.3% to the effective percentage of diabetics, be 75% to the effective percentage of severe patient, the effective percentage of alignment degree patient is 81.7%, be 93.3% to the effective percentage of patients with mild, show, more effective to patients with mild, and also therapeutic quality is also better, secondly being moderate patient, is finally severe patient.
Test 2: simultaneously randomly draw the detection that 30 are carried out treating OKT3, OKT4 content in T-lymphocyte Subsets from 180 patients, and by OKT3, OKT4 of 30 normal persons as a control group, result is as table 2.
Table 2:
Above-mentioned T cell subsets counts, adopts conventional alkaline phosphorus enzyme alkali resistance phosphoric acid enzyme process.
Table 2 detects data analysis: the OKT4 of diabetics is elevated to 38.8% from 37.3%, comparatively close to the level of normal person, and OKT3 drops to 27.1% from 31.5%, there is clear and definite decline, also comparatively close with normal person's 26.2%, the ratio of OKT4 and OKT3 rises to 1.43 from 1.18, illustrates that this herbal wine effectively can improve the immunity of diabetics.
Embodiment 2 and the medicated wine obtained by embodiment 3, through same clinical trial, find the effect also having treatment diabetes and promote immunity.
Claims (5)
1. a Ganoderma spore powder wine, is characterized in that, is made up of the raw material of following weight portion:
A: Ganoderma spore powder, 1 ~ 3 weight portion;
B: Xiang Tianguo, 1 ~ 3 weight portion;
C: the Spirit of alcoholic strength 40 ~ 65,8 ~ 15 weight portions.
2. Ganoderma spore powder wine according to claim 1, is characterized in that,
A: Ganoderma spore powder, 2 weight portions;
B: Xiang Tianguo, 1 weight portion;
C: the alcoholic strength of Spirit is 52 degree, 9 weight portions.
3. a preparation method for Ganoderma spore powder wine described in 1 or 2, is characterized in that, comprise the following steps:
(1) Ganoderma spore powder, Xiang Tianguo and Spirit have been weighed for subsequent use;
(2) will pulverize to sky fruit, by Ganoderma spore powder, be placed in container to sky fruit powder and Spirit;
(3) temperature is 20 ~ 40 DEG C, with ultrasonic cell disruption instrument to Feedstock treating 30min to 1h;
(4) immersion 3 ~ 6 hours is continued.
4. preparation method according to claim 3, is characterized in that, described Spirit is 100-4000 milliliter, and the frequency of ultrasonic cell disruption instrument is 25 ~ 35KHz, power is 500 ~ 1000W.
5. preparation method according to claim 4, is characterized in that, described Spirit is that the described ultrasonic cell disruption instrument frequency of 100-1000 milliliter is 30KHz, power is 800W, and the processing time is 30 minutes.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105327387A (en) * | 2015-11-04 | 2016-02-17 | 泉州市洛江区汇丰妇幼用品有限公司 | Traditional Chinese medicine health-care protective pad and preparation method thereof |
| CN107996928A (en) * | 2017-12-09 | 2018-05-08 | 肇庆市高新区伟瑞生物科技有限公司 | A kind of preparation method of fruit beverage |
| CN115141702A (en) * | 2022-06-30 | 2022-10-04 | 深圳市黑能石墨烯有限公司 | Method for preparing nano ganoderma spore wine by hammering and wet grinding |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105327387A (en) * | 2015-11-04 | 2016-02-17 | 泉州市洛江区汇丰妇幼用品有限公司 | Traditional Chinese medicine health-care protective pad and preparation method thereof |
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| CN107996928A (en) * | 2017-12-09 | 2018-05-08 | 肇庆市高新区伟瑞生物科技有限公司 | A kind of preparation method of fruit beverage |
| CN115141702A (en) * | 2022-06-30 | 2022-10-04 | 深圳市黑能石墨烯有限公司 | Method for preparing nano ganoderma spore wine by hammering and wet grinding |
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Application publication date: 20150909 |