TWI565469B - Herbal composition for cardiovascular health - Google Patents

Description

Helps cardiovascular health care herbal composition

The present invention relates to a Chinese herbal medicine composition capable of preventing hardening of blood vessels, promoting blood circulation, and lowering triglyceride in blood.

According to relevant literature, one-third of the world's annual deaths are due to cardiovascular disease. In Taiwan, cardiovascular disease also threatens middle-aged and older people over the age of 50.

Cardiovascular disease (CVD) refers to all heart and blood vessel diseases, including coronary heart disease, cardiac paralysis, angina pectoris, myocardial infarction, arrhythmia, hemorrhagic heart failure, etc., all of which are multiple pathogenesis machines. Diseases that turn to factors.

The causative agent of cardiovascular disease is caused by the interaction of multiple endogenous and exogenous risk factors, and the main cause is the deposition of fat and cholesterol. The most important pathological change is arteriosclerosis. Arteriosclerosis includes thickening and hardening of the arterial wall, which is reduced by blood flow due to the reduction of the inner diameter of the artery, and the contraction and relaxation ability and partial elasticity of the arterial wall are thickened and hardened. If it occurs in the cerebral artery, it causes a stroke in the brain, and if it occurs in the coronary artery, it causes myocardial infarction. Plasma lipid abnormalities and Oxidative stress are the most direct risk factors for atherosclerosis. Clinical tests and epidemiology use dyslipidemia as an indicator of atherosclerosis: TC is high ( 250mg/dl), TG is high (>200mg/dl), LDL-C is rising ( 200mg/dl) and HDL-C are low (<35mg/dl). In many animal experiments, it has been pointed out that dietary cholesterol intake will increase plasma total cholesterol (TC) and increase plasma low density lipoprotein-cholesterol (LDL-TC) particles and increase the number of particles. It increases the chance of suffering from cardiovascular disease.

Stroke and heart disease associated with dyslipidemia and atherosclerosis are the enemy of Chinese health. The biggest cause of cardiovascular disease is the so-called "three highs" such as high blood pressure, high blood fat and high blood sugar. According to the results of the 1997 high-level follow-up survey in Taiwan, patients with high blood pressure, high blood sugar or high blood lipids are more likely to have stroke, kidney or heart disease than the average person. However, the present invention mainly utilizes a mechanism for reducing hyperlipemia, which can contribute to reducing the morbidity and mortality of cardiovascular diseases.

In recent years, with the rise of the concept of health care and health care, in addition to the daily regular exercise to protect the health of the body, the way of eating health care supplies has become more and more important. Accordingly, the present invention provides a compound natural herbal composition, It can help cardiovascular health care, and can effectively reduce the incidence of cardiovascular disease, and thus achieve the effect of saving medical resources.

A herbal composition for cardiovascular health care, comprising 6-10 parts by weight of egg oil, 10-14 parts by weight of black fungus extract, 8-12 parts by weight of black bean extract, 8-12 parts by weight of thorn Five plus extract, 13-17 parts by weight of cassia seed extract, 10-14 parts by weight of Schisandra extract, 10-14 parts by weight of strontium extract, 10-14 parts by weight of jujube extract, 7-11 parts by weight Resveratrol.

The cardiovascular health care herbal composition as described above, which comprises 12 parts by weight of black fungus extract, 8 parts by weight of egg oil, 10 parts by weight of black bean extract, and 10 parts by weight of acanthopanax senticosus The extract, 15 parts by weight of cassia seed extract, 12 parts by weight of Schisandra extract, 12 parts by weight of strontium extract, 12 parts by weight of jujube extract, and 9 parts by weight of resveratrol.

The above-described cardiovascular health care herbal composition is as described above, wherein the resveratrol is derived from red wine.

The above-mentioned cardiovascular health care herbal composition, wherein each of the extracts is obtained through an extraction process, the extraction process includes a preparation process and an extraction procedure; and the preparation process mainly includes Chinese herbal medicine screening and a drying refining step; the extraction procedure includes pre-extraction treatment, low temperature pressurization, addition of a co-solvent, removal of the extract, ultrasonic shock and drying steps.

A cardiovascular health care herbal composition as described above, wherein the extraction procedure is performed in a 1:1 (v/w) manner with 75% alcohol and the extract material. After 24 hours, the supernatant was filtered and lyophilized at 65 ° C, and then the wine lyophilized powder was dissolved in pure water, and subjected to hot water extraction at 100 ° C for 30 minutes, followed by filtration.

The cardiovascular health care herbal composition as described above, wherein, in the preparation procedure, after the drying and refining step, a crude extraction and drying and further dilution step is further included.

The cardiovascular health care herbal composition as described above, further comprising a base component selected from the group consisting of starch, legumes, grains, animal feed or liquid.

The cardiovascular health care herbal composition as described above, wherein the herbal composition is in the form of a liquid solution, suspension or slurry, or in the form of a solid tablet, capsule or powder.

First figure: The effect of the herbal composition of the present invention on the weight adjustment effect of experimental animals

The second figure: the effect of the herbal composition of the present invention on the regulation of triglyceride in experimental animals

The third figure: the effect of the total herbal cholesterol regulation of the herbal composition of the present invention on experimental animals

Figure 4: Low-density lipoprotein regulation effect of the Chinese herbal composition of the present invention in experimental animals

Figure 5: High-density lipoprotein regulation effect of the Chinese herbal composition of the present invention in experimental animals

Figure 6: Effect of the ratio of total cholesterol to high density lipoprotein in the experimental animal of the present invention

For a more complete and clear disclosure of the technical content, the object of the invention, and the effects thereof, the present invention will be described in detail below, and reference should be made to the drawings and drawings. The cardiovascular health herbal composition comprises 6 to 10 parts by weight of egg oil, 10 to 14 parts by weight of black fungus extract, 8 to 12 parts by weight of black bean extract, and 8 to 12 parts by weight of acanthopanax senticosus. Extract, 13 to 17 parts by weight of cassia seed extract, 10 to 14 parts by weight of Schisandra extract, 10 to 14 parts by weight of strontium extract, 10 to 14 parts by weight of jujube extract, and 7 to 11 parts by weight of white Resveratrol. Among them: Egg oil is an essential oil extracted from the fresh and good egg yolk for a long time. The main ingredient of egg oil is lecithin, in addition to high-density lipoprotein (HDL, commonly known as high-quality cholesterol), unsaturated fatty acids (mostly with linoleic acid), vitamins E, A, D, etc., because of its main ingredients. It is lecithin, a nutrient that is very important to the human body, so egg oil is also commonly referred to as egg oil lecithin. Its main functions are:

1. Lecithin is the main component of the cell membrane and can keep the cells young.

2, can dissolve the cholesterol of the blood vessel wall, can maintain the young and toughness of blood vessels.

3, make the brain and nervous system active, very effective in preventing aging and Alzheimer's disease.

4, is a natural emulsifier, tranquilizer, diuretic.

Auricularia polytricha extract, its protein content is unmatched by rice, noodles, vegetables, etc. Its vitamin B2 content is ten times that of rice, noodles and Chinese cabbage, higher than pig, cow and lamb. ~5 times; every 100 grams of fresh fruiting body contains vitamin C up to 200 mg; and the calcium content is 30 to 70 times that of meat, and iron is up to 100 times higher than meat. As far as Chinese medicine is concerned, black fungus is sweet, flat, non-toxic, into the stomach, large intestine, with cooling blood to stop bleeding, activating blood and blood, benefiting the five internal organs, clearing the lungs and qi, promoting the intestines and strengthening the stomach, eliminating phlegm and laxative effects. As far as Western medicine research is concerned, it can reduce blood viscosity, prevent or dissolve thrombus, and alleviate coronary atherosclerosis. Its acidic polysaccharide has a 42.6% inhibitory effect on mouse sarcoma (S-180). Its main functions are as follows:

1. Promote blood circulation, prevent hardening of blood vessels, and promote blood circulation.

2, treatment of pain caused by trauma, blood circulation, nerve numbness, hand and foot pumping.

3, promote bowel movements, improve leakage, blood in the stool, hemorrhoids and varicose veins.

4, treatment of cold and wet waist and leg pain.

5, uterine bleeding and amenorrhea and other gynecological diseases.

6, improve anemia, osteoporosis.

7, lowering blood fat, is very helpful for cardiovascular and cerebrovascular diseases.

8, lose weight and lose weight.

Black bean extract, black beans are black seeds of the legume Glycinemax (L.) merr. Also known as black beans, black beans, sweet and flat. Black beans have high protein and low calorie properties. The unsaturated fatty acids contained in black beans can promote the metabolism of cholesterol, lower blood lipids, prevent cardiovascular diseases, and the high fiber content of black beans can promote gastrointestinal motility and prevent constipation.

Eleutherococcus senticosus extract, tastes soft, slightly bitter, warm, Buzhong, Yijing, strong bones, strong will, Qi and spleen, kidney and soothe the nerves. For the spleen weakness, physical weakness, loss of appetite, waist and knee pain, insomnia and more dreams are particularly effective.

Cassia Seed extract, bitter, sweet, salty, slightly cold, into the liver, kidney, large intestine. There are Qinggan Yishen, eyesight, and water and laxative effect. Indications of red eyes and swelling, shame and tears, blue-blind, finch, headache, dizziness, dim vision, cirrhosis, ascites, urinary adverse, habitual constipation. External treatment of swollen poison, dysentery and so on.

Schisandra chinensis extract, which is sour, sweet and warm. Return to the lungs, heart, kidney. Efficacy of lungs, kidney, Shengjin, sweating, phlegm. Indications treatment of lung deficiency and asthma cough, dry mouth for thirst, spontaneous sweating, night sweats, labor injury and thin, dreams slippery essence, long time diarrhea.

Goji berry extract, sweet, flat, liver and kidney, has nourishing liver and kidney, nourishing liver and eyesight, contains carotene, betaine, vitamin A, vitamin B1, vitamin B2, vitamin C and calcium, phosphorus Iron, etc., has the pharmacological effects of increasing white blood cell activity, promoting hepatocyte regeneration, and lowering blood pressure, lowering blood sugar, and blood lipids.

Jujube extract, sweet and warm, spleen and stomach, with Buzhong Yiqi, nourishing blood and calming the nerves, and alleviating the medicinal function can enhance the oxygen content in the blood and nourish the whole body cells.

Resveratrol can extend the life cycle of certain cells by up to 70%, has antioxidant effects, enhances vitality and appropriately alters the form of gene expression.

Wherein, each extract is obtained through an extraction process, and the extraction process includes a preparation process and an extraction process.

The preparation procedure mainly includes a Chinese herbal medicine screening and drying refining step; and the extraction procedure includes steps of pre-extraction treatment, low-temperature pressurization, addition of a co-solvent, removal of the extract, ultrasonic vibration and drying.

Further, the extraction procedure is to extract the raw material of the extract with 75% alcohol and the extract in a 1:1 (v/w) manner for 24 hours (pre-extraction treatment), and filter the supernatant to freeze at 65 ° C. After drying (low temperature pressurization), the wine lyophilized powder is dissolved in pure water (adding a co-solvent), and subjected to hot water extraction at 100 ° C for 30 minutes, followed by filtration (ultrasonic shock and drying).

Further, in the above preparation procedure, after the drying and refining step, the step of further extracting and drying and further diluting may be further included.

Wherein, the herbal health care herbal composition of the present invention further comprises a base ingredient which is a substance selected from the group consisting of starch, beans, grains, animal feed and liquid. Moreover, the herbal composition for cardiovascular health care can be in the form of a liquid solution, a suspension and a slurry, or can be in the form of a solid tablet, capsule or powder.

The resveratrol is taken from red wine.

<Example>

The cardiovascular health care herbal composition of the present invention comprises 12 parts by weight of black fungus extract, 8 parts by weight of egg oil, 10 parts by weight of black bean extract, 10 parts by weight of acanthopanax extract, 15 weight A portion of cassia seed extract, 12 parts by weight of Schisandra extract, 12 parts by weight of strontium extract, 12 parts by weight of jujube extract, and 9 parts by weight of resveratrol.

The herbal composition of the present invention was subjected to an animal experiment to verify that the herbal composition of the present invention does contribute to cardiovascular health care. Among them, the animals used in this experiment were male ICR mice (ICR mice) purchased from BioLASCO Taiwan Co. Ltd., Taiwan. ICR mice are 6 weeks old and weigh about 32g. They are housed in stainless steel iron cages and controlled by an automatic timer. They are given 12 hours of illumination per day and 08:00~20:00 for light. Period), 20:00~08:00 is the dark period, the ambient temperature is maintained at 21±2°C, and the relative humidity is 50-70%.

This experiment was conducted mainly in accordance with the "Guidelines for the Management and Use of Laboratory Animals" and the Guidelines of Care and Use of Laboratory Animals. After entering the animal center, the experimental animals were fed with normal feed (Basal diet, Product Code 5755) and reverse osmosis water for feeding for two weeks. All the experimental animals were randomly divided into two groups: the normal group (n=8) continued to feed the rats. The normal diet (<experiment group 1>) and the diseased animal group (n=24) were fed 2% high cholesterol feed (the composition is shown in Table 1). After feeding 12% high cholesterol diet for 12 weeks, after observing hypercholesterolemia, the following were randomly divided into the following <Experimental Group 2>, <Experimental Group 3>, <Experimental Group 4>, and different drugs (or physiological saline) were administered. Water) After 4 weeks of oral feeding, it was observed whether it could reduce hypercholesterolemia and delay the onset of atherosclerosis after 8 weeks from the start of feeding.

<Experimental group 1>

6-week male ICR + normal feed (when the guards were in control) - 8 ICR mice were given normal feed and allowed free access to food and water for a total of 8 weeks.

<Experimental group 2>

6 weeks male ICR group + 2% high cholesterol feed (when the blank control group) - ICR mice 6 were given 2% high cholesterol feed, after 12 weeks of feeding, given normal drinking water and free access to food and water, began The gastric tube was fed with physiological saline for 4 weeks.

<Experimental group 3>

6 weeks male ICR group + 2% high cholesterol feed (when positive control) - 6 ICR mice were given 2% high cholesterol feed, given normal drinking water after 12 weeks of feeding and allowed to freely feed and drink, start stomach The tube was fed with Clofibrate 10 mg/kg for 4 weeks.

<Experimental group 4>

6-week male ICR group + 2% high-cholesterol diet (when experimental group) - 6 ICR mice were given 2% high cholesterol feed, given normal drinking water after 12 weeks of feeding and allowed to Free feeding and drinking, starting the gastric tube feeding of the Chinese herbal medicine composition of the present invention 100 mg / kg (n = 6) for 4 weeks, for 28 consecutive days.

<Experimental group 5>

6-week male ICR group + 2% high-cholesterol diet (when the experimental group) - ICR mice 6 were given a diet containing 2% high cholesterol, given normal drinking water after 12 weeks of feeding and allowed to freely feed and drink, start the stomach The tube was fed with the herbal composition of the present invention at 300 mg/kg (n=6) for 4 weeks for 28 consecutive days.

The results shown in the first to sixth figures are the results of body weight and triglyceride, total cholesterol, low density lipoprotein, high density lipoprotein, total cholesterol and high density lipoprotein ratio in ICR mice after the above animal test. . among them:

<Body measurement>

The first figure shows that after the above animal test, the body weight of ICR mice in the experimental groups 1 to 5 was observed before and after administration, and it was shown that the Chinese herbal medicine composition of the present invention was 100 mg/kg and 300 mg orally administered continuously for 4 weeks. After /kg, the body weight of ICR mice was slightly lower than before administration.

<Measurement of blood biochemical value>

The above five groups of ICR mice were tested for biochemical values. If the ICR mouse is not anesthetized, it needs to be secured with a Baoding device. Place the tail in warm water at 40 ° C or irradiate with a heat lamp for 5 to 10 minutes to dilate the blood vessels of the tail, draw blood from the tail vein of the left and right sides of the tail or the ventral tail artery with a 23 or 21 G needle, or only 21G. The butterfly needle is inserted into the tail artery, and it is confirmed that blood is discharged and then taken up by the blood collection tube. Take about 0.5ml Whole blood, after centrifugation at 5000 rpm for 10 minutes, 0.2 ml of serum was taken for biochemical value experiments.

The biochemical value experiment was performed by a fully automatic analyzer (HITACHI 7170 Autoanalyzer) provided by Nantai University of Science and Technology for analysis of blood total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride. All data of the present invention were analyzed and plotted using SigmaPlot 10.0 for data processing. The statistical results of the experimental results are expressed as mean ± standard error (mean ± S. E.). The sample difference uses ANOVA plus post hoc test (Scheffe method) to calculate the P value, * is P value less than 0.05, ** is P value less than 0.005, *** is P value less than 0.001, and its statistical significance is high The cholesterol group was compared with other experimental groups. When the P value was less than 0.05, the two samples showed statistically significant differences.

<<Triglyceride>>

The second figure shows that after the above animal test, the ICR mice in the experimental groups 1 to 5 were observed before and after the administration of the triglyceride, which showed that the Chinese herbal medicine composition of the present invention was orally administered for 4 weeks. After /kg and 300mg/kg, the triglyceride in ICR mice was significantly lower than before administration.

<<Total cholesterol>>

The third panel reveals that the total cholesterol in the ICR mice in the experimental groups 1 to 5 before and after administration was observed after the above animal test, and it was shown that the Chinese herbal medicine composition of the present invention was orally administered for 100 weeks. After 300mg/kg, the total cholesterol in ICR mice was significantly lower than before administration, especially for 4 weeks. The experimental group of the Chinese herbal medicine composition of the present invention was administered at 100 mg/kg.

<<Low density lipoprotein>>

The fourth panel reveals that after the above animal test, the low-density lipoprotein of the ICR mice in the experimental groups 1 to 5 was administered before and after administration, and it was shown that the Chinese herbal medicine composition of the present invention was orally administered for 4 weeks. After /kg and 300 mg/kg, the low-density lipoprotein in the ICR mice was significantly lower than before administration, especially the experimental group in which the Chinese herbal medicine composition of the present invention was 100 mg/kg orally administered for 4 weeks.

<<High Density Lipoprotein>>

The fifth figure reveals that after the above animal test, the high-density lipoprotein of the ICR mice in the experimental groups 1 to 5 was administered before and after administration, and it was shown that the Chinese herbal medicine composition of the present invention was orally administered for 4 weeks. After /kg and 300mg/kg, the high-density lipoprotein in ICR mice was higher than before.

<<Total cholesterol and high density lipoprotein ratio>>

The sixth figure shows that after the above animal test, the ratio of total cholesterol to high-density lipoprotein in the ICR mice in the experimental groups 1 to 5 before and after administration was observed, and it was shown that the invention was orally administered for 4 weeks. After the Chinese herbal medicine composition 100mg/kg and 300mg/kg, the ratio of total cholesterol to high-density lipoprotein in ICR mice was significantly lower than that before administration, especially the experiment of orally feeding the Chinese herbal medicine composition 100mg/kg for 4 weeks. group.

From the animal test data of the first to sixth figures, the composition of the present case is Adjusting the ratio of triglyceride, total cholesterol, low-density lipoprotein, total cholesterol and high-density lipoprotein has a very good effect, and it is also effective in regulating body weight and high-density lipoprotein, especially when the dosage is 100mg/kg. It is preferred to reduce the effects of triglyceride, total cholesterol, low density lipoprotein, total cholesterol and high density lipoprotein ratio.

The above is only a part of the embodiments of the present invention, and is not intended to limit the present invention. It is intended to be included in the scope of the present invention.

In summary, the embodiments of the present invention can achieve the expected use efficiency, and the specific technical means disclosed therein have not been seen in similar products, nor have they been disclosed before the application, and have completely complied with the patent law. The regulations and requirements, the application for invention patents in accordance with the law, and the application for review, and the grant of patents, are truly sensible.

Claims (6)

A Chinese herbal medicine composition comprising 6-10 parts by weight of egg oil, 10-14 parts by weight of black fungus extract, 8-12 parts by weight of black bean extract, 8-12 parts by weight of Acanthopanax senticosus extract, 13~ 17 parts by weight of cassia seed extract, 10 to 14 parts by weight of Schisandra extract, 10 to 14 parts by weight of strontium extract, 10 to 14 parts by weight of jujube extract, and 7 to 11 parts by weight of resveratrol; The extracts are obtained through an extraction process, the extraction process includes a preparation process and an extraction process; the preparation process mainly includes a Chinese herbal medicine screening and drying refining step; the extraction process includes pre-extraction treatment, low temperature Pressurizing, adding 75% alcohol, taking out the extract, ultrasonic oscillating and drying step, the extraction procedure is followed by extraction in a 1:1 (v/w) manner with 75% alcohol and the raw material of the extract for 24 hours. After the supernatant was filtered and lyophilized at 65 ° C, the lyophilized powder of the wine extract was dissolved in pure water, and then subjected to hot water extraction at 100 ° C for 30 minutes, followed by filtration. The herbal composition according to claim 1, which comprises 12 parts by weight of black fungus extract, 8 parts by weight of egg oil, 10 parts by weight of black bean extract, and 10 parts by weight of Acanthopanax senticosus extract. 15 parts by weight of cassia seed extract, 12 parts by weight of Schisandra extract, 12 parts by weight of strontium extract, 12 parts by weight of jujube extract and 9 parts by weight of resveratrol. The Chinese herbal medicine composition according to claim 1, wherein the resveratrol is taken from red wine. The herbal composition of claim 1, wherein the herbal composition further comprises a base component, the base component being a material selected from the group consisting of starches, Beans, grains, animal feed and liquids. The Chinese herbal medicine composition according to claim 4, wherein when the base component of the Chinese herbal medicine composition is a liquid, the liquid is one of a solution, a suspension and a slurry form, or the Chinese herbal medicine composition When the base component is a solid, the solid is one of a form of a tablet, a capsule, or a powder. A use of a herbal composition according to any one of claims 1 to 5 for the preparation of a cardiovascular health care composition, which is administered to a desired individual at an effective dose to achieve cardiovascular protection .