RU2333677C2 - Dietary supplement - Google Patents

Abstract

FIELD: food industry.

SUBSTANCE: invention relates to food industry and, particularly, to dietary supplement production, which intensify protection functions of body. Dietary supplement contains ingredients of vegetable origin and chitosan. Besides, complex extract from Manchurian aralia roots, rose hips, spiny eleuterococus leaves and roots and black chokeberry fruits are used as ingredients of vegetable origin. Dietary supplement ingredients are used in the following ratio: complex extract from Manchurian aralia roots; rose hips, spiny eleuterococus leaves and roots and black chokeberry fruits - 165.0-195.0 kg; chitosan - 85.0-95.0 kg.

EFFECT: production of dietary supplement with systematic medication and intensifying immune-enhancing effect.

2 cl

Description

The invention relates to the food industry, in particular to the production of biological additives that enhance the protective functions of the body.

Known biological food supplement, including eleutherococcus extract and sweetener, which is used as powdered sugar, or xylitol, or sorbitol, or glucose. The supplement increases mental performance, reduces fatigue during physical exertion, enhances visual and hearing acuity, regulates blood pressure, metabolism and blood sugar. RF patent №2134045, А23L 1/30, 1998

A drug is known to have anti-inflammatory and analgesic effects, containing an alcohol-based extract from plant materials and a pharmaceutically acceptable carrier, chitosan gel. Poultry farmers are used as plant materials. The drug can be used in the complex treatment of a number of muscle and neuralgic diseases, acute and chronic diseases of the musculoskeletal system. RF patent No. 2154488, A61K 35/78, 2000

Known therapeutic food composition "Herbamarin", used as a dietary supplement and element of therapeutic nutrition. The composition contains a sweetener, soluble dietary fiber and biologically active substances, which are used as extracts of rose hips, and / or St. John's wort and / or lozdedets, and / or licorice roots, and / or protein-containing raw materials, and / or biologically active substances of marine hydrobionts. The composition improves the function of the gastrointestinal tract, normalizes cardiovascular activity, lowers cholesterol and reduces body weight. RF patent №2093046, А61К 35/78, 1996

Known biologically active composition based on chitosan gel or chitosan suspension containing components of vegetable and / or animal origin, which are used as oil or flour of wheat germ, peach oil, cocoa butter, sea buckthorn, milk thistle, calendula and / or bee products. The invention improves the penetrating ability of the components and the activity of the composition. RF patent No. 2209069, А61К 31/722, 2001

This solution is the closest to the one proposed.

However, none of the known biologically active compositions shows an enhanced immunostimulating effect.

An object of the present invention is to provide a biologically active agent that has a general strengthening and enhanced immunostimulating effect, heals the body, improves the activity of the cardiovascular system, enriches with oxygen and relieves nervous and physical fatigue.

This problem was solved by the applicant by creating a biologically active food supplement containing components of plant origin and chitosan, while a complex extract from the roots of Manchurian aralia, rose hips, leaves and roots of prickly Eleutherococcus and aronia fruits is used as components of plant origin, in the following ratio components:

complex extract from the roots of Aralia Manchurian, rose hips, leaves and roots of prickly Eleutherococcus and chokeberry - 165.0-195.0 kg;

chitosan - 85.0-95.0 kg.

In this case, ethyl alcohol of 39.5-40.5% is used as an extractant, in the following ratio of components:

roots of Aralia Manchurian - 0.3-0.6 kg

rose hips - 7.5-9.5 kg

prickly Eleutherococcus leaves - 2.0-4.0 kg

prickly Eleutherococcus roots - 75.0-85.0 kg

chokeberry fruits - 10.0-12.0 kg

ethyl alcohol 95% - 77.0-79.1 kg

purified water - 126.0-130.0 kg

The roots of Manchu Aralia contains saponins, glycosides, essential oils. It stimulates the central nervous system (surpasses ginseng tincture in activity), has a general tonic, hypertensive and hypoglycemic effect. It increases appetite, working capacity, weakens the feeling of fatigue, has a stimulating effect on the cardiovascular system, and helps to increase the vital capacity of the lungs and muscle strength. It enhances redox processes in tissues, glucocorticoid function of the adrenal glands, increases the phagocytic activity of leukocytes and the body's resistance.

Rose hips are an excellent multivitamin. They also have choleretic and anti-sclerotic effects, lower blood cholesterol. The high content of ascorbic acid and carotenoids contributes to the positive effect of the fruit on hematopoietic function.

Eleutherococcus stimulates the central nervous system, increases working capacity, improves vision, metabolism and appetite.

The roots contain glucose, sugar, starch, polysaccharides, wax, resins, pectin substances, coumarin derivatives, fatty and essential oils, trace elements, eleutherosides.

Eleutherococcus extract increases mental performance, reduces fatigue during physical exertion, enhances visual acuity, improves hearing, reduces blood cholesterol.

Chokeberry fruits contain sugar (glucose, fructose, sucrose) in an amount of 4.6 to 10.2%, depending on the place of growth; organic acids (in terms of the content of organic acids, the fruits of the mountain ash of Chokeberry are significantly superior to tangerines, strawberries, raspberries and red currants); tanning 0.3-0.6%; pectin up to 0.5% and coloring matter.

Fruits are very rich in vitamins: vitamins C, B2, B9, E, P, PP, carotene. Especially a lot of substances with P-vitamin activity. P-vitamin complex is represented mainly by flavonoids (catechins, anthocyanins, rutin, quercetin). The total content of these substances can reach 2%.

Chitosan - a natural polymer obtained from the shell of crustaceans (shrimp and crab), has a number of unique properties that put it in first place among biological sorbents. Chitosan is the most effective absorber of fat and cholesterol. One molecule of chitosan is able to bind and remove from the body an amount of fat more than 10 times the weight of the molecule itself. At the same time, chitosan does not violate the processes of digestion and absorption of other substances (in particular vitamins), does not cause disturbance of the intestinal microflora. Among the sorbents, chitosan is the only one with its own biological activity.

Due to the high absorption capacity of chitosan (1 part of chitosan absorbs 2 parts of concentrated water-alcohol phytoextracts), it was possible to introduce the maximum amount of concentrated phytoextracts into the composition of the biologically active additive and to provide a high content of biologically active substances: vitamins, organic acids, tannins, trace elements, flavonoids and adaptogens.

Chitosan, as a vehicle, carries these biologically active substances throughout the body and prolongs their action.

Chitosan is fully compatible with human tissues, has wound healing, antiviral, antibacterial and anti-allergic effects, as well as antitumor activity.

The composition of this biologically active additives introduced only natural biologically active substances of plants and the natural polymer of chitosan obtained from the crab shell. Chitosan (poly-N-acetyl-D-glucosamine) is very close in structure to mucopolysaccharides of cell membranes and extracellular substance of various human organs. Chitosan is able to capture the active forms of oxygen, that is, to play the role of an antioxidant with a wide spectrum of action. When ingested, part of chitosan is broken down, absorbed into the bloodstream and absorbed by the body in the form of low molecular weight compounds, the other part turns into a gel-like mass, adsorbs toxic substances and cleanses the intestines.

The soluble part of chitosan, entering the blood and lymph, leads to an increase in the immunostimulating action of adaptogens (phytoextract eleutherosides), revealing the synergistic effect of the components included in the supplement.

The present biologically active food supplement is prepared as follows.

The estimated amount of each type of plant material, except for the fruits of chokeberry - 12.0 kg, which can not be chopped (leaves - 4.0 kg and the roots of prickly Eleutherococcus - 85.0 kg, Manchurian aralia roots - 0.6 kg, rosehip low vitamin or Daurian rosehip - 9.5 kg), crushed on a crusher KDU-2.0-1 until it passes through a sieve with a diameter of 7 mm.

As extractant, ethyl alcohol of 40% is used, to obtain which the calculated amount of ethyl alcohol of 95% and purified water are mixed.

The preparation of the complex extract is carried out in a self-unloading percolator, in which the obtained crushed mixture and the fruits of mountain ash are alternating layers are loaded, while insisting for 48 hours, draining the first portion and repeating the operation three times. All plums are combined in a collection. The extract is decanted.

The estimated amount of crab chitosan (TU 9289-003-49857769-2003) is sieved through a vibrating screen, loaded into a mixer and the calculated amount of the complex extract is added. Stirred for 10-15 minutes until a homogeneous friable mass.

The resulting mass is granulated through a sieve with a hole diameter of 5 mm and dried under natural conditions on the trays of a shelf dryer for a day.

The product is rubbed through a sieve of a granulator with a diameter of 1-3 mm and packaged in hard gelatin capsules of 0.2 grams. The mass fraction of the sum of eleutherosides in terms of eleutheroside B is at least 0.9 mg / g of product.

Organoleptic and physico-chemical characteristics of the finished product:

Capsules with granules in the form of grains of round, cylindrical or irregular shape, the granule size is 0.2-3.0 mm, the number of smaller and larger granules should not exceed 20% in total.

Color - from light brown to brown, interspersed with a darker or lighter color is allowed.

The taste is characteristic of chitosan with a specific plant flavor characteristic of eleutherococcus, aralia, wild rose, chokeberry.

Smell - weak, specific, without extraneous odors.

Losses in mass upon drying - not more than 10%.

Mass fraction of eleutherosides - not less than 0.9 mg / g of product.

Disintegration (0.5 g sample) - no more than 15 minutes.

The proposed biologically active additives used their own biological activity of chitosan, its ability to act as a “depot” for other biologically active substances, in particular a complex aqueous-alcoholic extract from the leaves and roots of eleutherococcus, aralia roots, chokeberry fruits and rose hips, providing them gradual release and increase in the duration of their action. In addition, the inherent effect of chitosan on enhancing the action of other biologically active substances leads to an increase in the immunostimulating action of adaptogens (phytoextract eleutherosides).

On the basis of the Far Eastern Central Clinical Basin Hospital (DTSKBB), the authors conducted studies of the proposed biologically active food additives. The research results are set out in the help attached to the description. See Appendix 1.

As studies have shown, this dietary supplement has a general strengthening and enhanced immunostimulating effect (due to the sum of eleutherosides and chitosan), heals the body, improves the activity of the cardiovascular system, enriches with oxygen and relieves nervous and physical fatigue.

Recommended:

during training and competition for athletes;

during periods of intense physical and mental stress;

during exams for students and schoolchildren;

to enhance immunity;

for adaptation when changing time zones;

Annex 1.

REFERENCE about the tests of biologically active food additives “Phytocomplex with chitosan”.

On the basis of the Far Eastern Central Clinical Basin Hospital (DTsKBB), a study was made of the biologically active food supplement “Phytocomplex with chitosan”, which was made according to the original technology: from a complex water-alcohol extract from the leaves and roots of Eleutherococcus, aralia roots, chokeberry, rosehip and chitosan crab. Due to the high absorption capacity of chitosan, it was possible to introduce the maximum amount of concentrated phytoextracts into the composition of the biologically active additive and to provide a high content of biologically active substances: vitamins, organic acids, tannins, trace elements, flavonoids and adaptogens.

The experimental group included 20 patients with acute pneumonia (men aged 36 to 52 years) who were hospitalized in the therapeutic department of the Children's Clinical Hospital, as well as 15 students of Vladivostok State Medical University (VSMU) (10 women and 6 men aged 19 to 22 years) and 25 employees of the Children's Clinical Clinical Hospital and the Department of Propaedeutics of Internal Diseases of the Voronezh State Medical University (19 women and 6 men aged 29 to 55 years). As a control, groups similar in sex and age were studied, which received only chitosan in capsules. The same dosage was used as in the “Phytocomplex with chitosan”.

All subjects expressed a desire and agreed to participate in a clinical trial, the data of which were recorded in a special registration card, agreed with the manufacturer.

The cards, wound up on all the subjects, included a questionnaire on a medical assessment of the quality of life (a modified WHO questionnaire), a general clinical study, as well as laboratory and instrumental methods. Questioning and objective research were carried out initially and then weekly for 3 weeks, and laboratory and instrumental methods of research - twice (before the test and at the end of it - 3 weeks from the start of the reception).

Subjects of the 1st group - patients with acute pneumonia - took 2 capsules of “Phytocomplex with chitosan” in a daily dose of 2.0 in the morning (during breakfast).

Subjects of the 2nd group (students) and the 3rd group (employees) took 1 capsule - a daily dose of 1.0 in the same mode.

Persons with contraindications to taking “Phytocomplex with chitosan” (severe forms of cardiovascular disease, diabetes, epilepsy, increased irritability, insomnia, high blood pressure, fever, and individual intolerance) were excluded from the study.

During the test period (January-February 2005), staff and students did not take any medications or nutritional supplements. Patients with acute pneumonia received treatment complexes according to the severity of the disease, including antibacterial, detoxification, anti-inflammatory therapy. “Phytocomplex with chitosan” was prescribed additionally from the 3rd day from the beginning of normalization of body temperature, which corresponded to approximately 7-10 days from the onset of the disease.

After a 3-week course of taking the drug, 98.3% of the subjects were optimistic about their health and their prognosis, 78.4% noted a good physical and 83.3% emotional state. A good mood was observed in 91.3%.

A positive clinical effect was noted in the group of patients with acute pneumonia, in whom, in comparison with the control group, the symptoms of inflammation earlier stopped, the general condition improved. In the group of patients receiving “Phytocomplex with chitosan”, a generally earlier positive dynamics was noted in 98.3% of the normalization of x-ray data, in contrast to the control group - 88.2%, which led to a decrease in the length of hospital stay of patients of the experimental group by compared with the control at 3.1 f / day.

The dynamics of objective data showed an improvement in overall well-being, an increase in appetite in 18 people, especially in the group of patients with acute pneumonia. A positive effect was noted after taking the drug, there was a normalization of blood pressure in 15 of 17 patients, accompanied by the disappearance of weakness, headaches and dizziness, which was significantly different from the control group (taking only chitosan in capsules), where the hypotension detected in 12 subjects remained stable for total observation.

When analyzing the state of the respiratory system in groups receiving “Phytocomplex with chitosan”, it was noted that only 5 cases of acute respiratory viral infections (12.5%) were observed among students and staff, while in the control group (receiving chitosan in capsules) , 28 cases of acute respiratory viral infections (23.3%) were noted - the difference is significant and significant.

The subjects noted an increase in performance, mental activity. In the group of students, performance analysis and test control were carried out within a month before taking the “Phytocomplex with chitosan” and a month after - the average score before participating in the study was 3.8; and after a course of prevention - 4.2; Test writing time decreased from 30 minutes to 18 minutes for the whole group. In the control group of students receiving chitosan in capsules, the average score before and after admission was 3.8; test writing time did not change and amounted to 30 minutes for the whole group.

FINDINGS:

1. A biologically active food supplement - “Phytocomplex with chitosan” has a tonic and anti-inflammatory effect, has a light tonic and adaptive effect.

2. It is recommended to increase the reactivity of the body, improve the physical and emotional state, increase efficiency, adapt the respiratory system of both healthy and sick people who have experienced acute pneumonia, especially during outbreaks of acute respiratory viral infections, as well as for the correction of hypotension.

3. In the course of clinical trials, the daily dose of “Phytocomplex with chitosan” 1.0 g (for healthy) and 2.0 g (after pneumonia) taken in the morning during meals was effective, with the onset of clinical effect after a week of administration and the maximum action in 14-21 days. The minimum course duration was 21 days.

4. “Phytocomplex with chitosan” can be recommended as a biologically active additive, does not cause allergic and adverse reactions, is well tolerated, tastes good, and is available in packaging that is convenient for the consumer.

Claims (2)

1. Dietary supplement containing components of plant origin and chitosan, characterized in that as a component of plant origin use a complex extract from the roots of Aralia Manchurian, rose hips, leaves and roots of prickly Eleutherococcus and chokeberry, in the following ratio of components: complex extract from the roots of the Aralia of Manchurian, rose hips, leaves and roots of prickly Eleutherococcus and the fruits of chokeberry - 165.0-195.0 kg; chitosan - 85.0-95.0 kg. 2. The dietary supplement according to claim 1, characterized in that ethyl alcohol of 39.5-40.5% is used as extractant in the following ratio of components: roots of aralia manchurian 0.3-0.6 kg dog-rose fruit 7.5-9.5 kg prickly eleutherococcus leaves 2.0-4.0 kg prickly eleutherococcus roots 75.0-85.0 kg chokeberry fruits 10.0-12.0 kg ethyl alcohol 95% 77.0-79.1 kg purified water 126.0-130.0 kg