RU2466735C2 - Drug for treating chronic fatigue syndrome, work capacity increase, treatment and prevention of acute respiratory viral infections - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: composition contains ginseng extract, eleuterococcus extract, orange peel extract, L-taurine, fructose, a preserving agent, a sweetening agent, a flavouring agent and water.

EFFECT: introduction of the composition reduces the length of treatment of the patients with acute respiratory diseases and provides higher working capacity with no side effects.

2 cl, 5 ex, 1 tbl

Description

The invention relates to the pharmaceutical industry, namely to the development and production of compositions used to relieve fatigue and improve performance, treatment and prevention of acute respiratory viral infections.

The leading symptoms of chronic fatigue syndrome are: weakness, headache, abdominal pain, sore throat, eye pain or photophobia, painful lymph nodes, myalgia and / or arthralgia, sleep disturbance, a sharp decrease in intellectual abilities (memory impairment, distraction), symptoms depression (tearfulness, emotional instability, irritability, obsession), neurological symptoms (impaired coordination of movements, paresthesia). Physical signs include: persistent decrease in body temperature, non-exudative pharyngitis, enlarged or painful lymph nodes on palpation. For the diagnosis of CFS, you must have the basic criteria for the disease in combination with six of the eleven leading symptoms of CFS and two physical signs, or the presence of the main criteria in combination with the eight leading symptoms. In the prior art, performance enhancing preparations containing ginseng (Panax ginseng S. A. Meu) in the form of a tincture (Tinctura ginseng) representing diluted alcoholic extract obtained by extraction of dried roots with a 70% standard in a ratio of 1:10 (Mashkovsky M .D., 1985).

A tool with a restorative and adaptogenic effect based on plant materials, characterized in that it includes ginseng, rosehip and echinacea, taken in a ratio of 1: 4: 2, respectively (Application 2001121971/14, 07.08.2001).

A remedy for the prevention and symptomatic treatment of chronic fatigue syndrome, characterized in that it is a mixture of dry extracts from rhizomes with safflower-root left roots, ginseng roots, rhizomes with eleutherococcus roots, nettle grass, St. John's wort in a ratio of 5: 2: 1: 2: 1 (Patent RU No. 2390348).

The technical task of the invention is the creation of funds with an expanded spectrum of pharmacological action. The stated technical problem is achieved due to the synergy of the incoming composition, which contains, in addition to ginseng extract and eleutherococcus extract, an orange peel extract, L-taurine in the following ratio in wt.%:

Orange Extract 0.1-30

Eleutherococcus extract 0.1-10

L-Taurine 0.1-10

Ginseng Root Extract 0.1-10

Fructose 1-30

Preservative 0.01-1.0

Sweetener 0.001-1.5

Fragrance 0.001-0.5

Water is the rest.

All ingredients included are approved for use.

The extracts included in the composition can be dry, thick and liquid.

Bitter orange peel extract contains various substances: citric acid; ascorbic acid, vitamins C, B1 and P, trace elements (calcium, potassium, phosphorus and many others), antioxidants up to 2% of essential oil.

Eleutherococcus extract has a stimulating effect on the central nervous system, increases physical and mental performance, stimulates the cardiovascular system.

Ginseng extract contains a complex of biologically active substances - mainly saponin glycosides-ginsenosides, as well as essential oils, styrene, peptides, vitamins and minerals. Ginseng extract belongs to the group of adaptogens, that is, it improves tolerance to various adverse conditions, including various stresses, and increases the nonspecific resistance of the body. Ginseng extract has a stimulating effect on the central nervous system, increases mental and physical performance, stimulates the metabolism and energy, cellular activity, improves the absorption of oxygen by the cells of the body and, thus, helps to significantly increase the energy potential of a person. Ginseng extract regulates the functioning of the endocrine glands, slightly increases blood pressure.

The composition does not contain doping substances included in the list of WADA, psychotropic substances,

The concentration of the composition is convenient for inclusion in more diluted preparations (for example, drinks, sprays, syrups, mashed potatoes) concentrations of active substances are justified by the average daily rate of the physiological needs of the body.

The composition may further comprise pharmaceutically and pharmacologically compatible minerals, carotenoids and / or flavonoids, antioxidants, enzymes or other medicinal substances, amino acids, protein, vitamins, hormones (hormone-like substances) and sterols.

The water used as a solvent can be deionized, purified, injectable and of other quality that is approved for oral use.

Instead of fructose, it is allowed to use other sugar approved for use in the food industry.

Case Study 1

Under sterile conditions, 20% of water is measured, in which 1% fructose is dissolved in the following sequence, dry extract of orange peel 0.1%, dry extract of ginseng roots 0.1%, dry extract of Eleutherococcus 0.1%, L-taurine 0.1 %, sweetener (sodium saccharinate) 0.001%, flavor (natural orange) 0.001%, preservative (potassium sorbate) 0.01%, thoroughly homogenize and bring with water to 100%.

Case Study 2

Under sterile conditions, 5% of water is measured, in which 30% of fructose is dissolved, a thick extract of orange peel 30%, a thick extract of ginseng roots 10%, a thick extract of Eleutherococcus 10%, L-taurine 10%, sweetener (sucralose) 1 , 5%, flavor (natural raspberries) 0.5%, preservative (sorbic acid) 1%, thoroughly homogenize and bring with water to 100%.

Case Study 3

Under sterile conditions, 10% of purified water is measured, in which 20% of fructose is dissolved in the following sequence, liquid extract of orange peel 20%, liquid extract of ginseng roots 5%, liquid extract of Eleutherococcus 5%, L-taurine 3%, sweetener (0.5 % potassium acetylsulfate, 0.5% sodium cyclomat, 0.5% sodium saccharin) 1.5%, flavor (natural lemon) 0.1%, preservative (sodium benzoate) 0.8%, thoroughly homogenize and bring with purified water up to 100%.

Case Study 4

In sterile conditions, 20% of injection water is measured, in which sucrose is dissolved in 20%, a thick extract of orange peel 10%, a thick extract of ginseng roots 3%, a thick extract of Eleutherococcus 3%, L-taurine 2%, 0.01% lutein , 0.05% rutin, 0.001% tocopherol mixture, 0.1% bromelain, 0.005% caffeine, 0.1% glutamine, 1% protein complex, 0.1% vitamin C, 0.05% phytosterol, 0.1% sweetener ( stevioside) 1%, natural orange flavor 0.5%, preservative 1%, thoroughly homogenize and bring injection water to 100%.

Case Study 5

In sterile conditions, 20% deionized water is measured, in which sucrose 20% is dissolved, a thick extract of orange peel 10%, a thick extract of ginseng roots 3%, a thick extract of Eleutherococcus 3%, L-taurine 2%, 0.01% lutein , 0.05% rutin, 0.001% tocopherol mixture, 0.1% bromelain, 0.005% caffeine, 0.1% glutamine, 1% protein complex, 0.1% vitamin C, 0.05% phytosterol, 0.1% sweetener (stevioside) 1%, natural orange flavor 0.5%, preservative 1%, thoroughly homogenized and adjusted to 100% with deionized water.

A clinical study of the composition confirmed safety, good tolerance and showed therapeutic efficacy in the treatment of acute respiratory viral infections, for the treatment of chronic fatigue syndrome, and increased performance. Studies were conducted on 30 patients with asthenic manifestations of various origins. The age of the subjects ranged from 21 to 46 years. Among the patients were 18 men and 12 women. The proposed composition was taken orally, one bottle (11 ml) in the evening. The course lasts 3 weeks. According to the set of diseases, gender and age, the test and control (took the composition of the prototype) groups are identical. Admission of the proposed composition contributed to the reduction of the main symptoms of asthenic syndrome in this category of patients (weakness, increased fatigue, lethargy, etc.).

Assessment of adaptogenic stress-correcting activity of the proposed tool was determined during emotional and physical stress.

The effect of the composition was studied on 20 white outbred male mice weighing 18-20 g using a swimming model of animals with 5% weight by weight at a water temperature of 20 ° C. Mice were divided into 2 groups - control and experimental (10 in each). The proposed composition was given to animals for 1 week at a dose of 1100 mg / kg per day. The load was performed three times (repeated - 3 and 24 hours after the first).

Significant differences in the duration of swimming of mice of the experimental group were observed at each of 3 loads. At the same time, the degree of increase in the duration of swimming of experimental animals in relation to control increased proportionally. The difference with the control group after 1, 3 and 24 hours was 42.59%, 51.0% and 62.7%, respectively, which characterizes the positive impact on learning processes

To study the treatment and prevention of acute respiratory viral infections, a group of 7 people from the therapeutic department was created, who belong to the high-risk group by contact. He was given a course: taking 11 ml at night for 14 days. The control group included 7 employees who did not receive preventive treatment. The results are presented in table 1.

During therapy with this composition, a significant, significant decrease in the severity of symptoms such as chills, runny nose, headache, general weakness and malaise was noted. The phenomena of conjunctivitis (photophobia, lacrimation, redness of the mucosa) were stopped in all patients on the third or fourth day of therapy.

The average duration of treatment in the group of patients with acute respiratory viral infections who received a therapeutic and prophylactic composition was 6.0 ± 0.4 days. In the group of ARVI patients who did not receive the treatment and prophylactic composition, symptoms of intoxication, catarrhal phenomena, changes in the respiratory tract were reliably stopped much later. The average duration of treatment in this group of patients was 8.9 ± 0.3 days.

As can be seen from the table, the incidence of ARVI against the background of the proposed composition was lower. Thus, the claimed composition has the claimed therapeutic and prophylactic effect, which makes it expedient to include it in the treatment and rehabilitation of patients with acute respiratory diseases, and also to use it as a prophylactic. The recommended course of admission is 2 weeks.

Thus, the studies showed the possibility of using the proposed composition for the treatment of chronic fatigue syndrome, increase efficiency, as well as for the treatment and prevention of acute respiratory viral infections.

Table 1 The results of the use of the composition for the prevention and treatment of acute respiratory viral infections among adults at risk Indicators The main group, the amount in% Control group, amount in% The number of acute respiratory viral infections 10 fifty The presence of complications one twenty The presence of repeated cases of SARS 0 one

Claims (2)

1. Composition for the treatment of chronic fatigue syndrome, improving performance and prevention of acute respiratory viral infections, containing extracts of ginseng and Eleutherococcus, characterized in that it further contains an extract of the peel of an orange, L-taurine, fructose, sweetener, flavoring, preservative, water in the following ratios , wt.%:
orange peel extract 0.1-30.0 eleutherococcus extract 0.1-10.0 L-Taurine 0.1-10.0 ginseng extract 0.1-10.0 fructose 1.0-30.0 preservative 0.01-1.0 sweetener 0.001-1.5 flavor 0.001-0.5 water rest 2. The composition according to claim 1, characterized in that the extracts can be dry, liquid, thick.