KR20010009653A - Composition for treating sexual dysfunction - Google Patents
Composition for treating sexual dysfunction Download PDFInfo
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- KR20010009653A KR20010009653A KR1019990028115A KR19990028115A KR20010009653A KR 20010009653 A KR20010009653 A KR 20010009653A KR 1019990028115 A KR1019990028115 A KR 1019990028115A KR 19990028115 A KR19990028115 A KR 19990028115A KR 20010009653 A KR20010009653 A KR 20010009653A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Description
본 발명은 아미노산 L-알기닌,인삼 추출물, 은행잎 추출물, 가시오가피추출물을 함유하는 것을 특징으로 하는 발기부전치료용 조성물에 관한 것으로서, 보다 상세하게는 L-알기닌 결정성 분말 5∼200중량부, 진세노사이드가 5-30% 함유된 인삼 추출물 5-100중량부, 엘레우쎄로사이드(Eleutheroside)가 0.05-0.45% 함유된 가시오가피 추출물 5-50중량부 및 징코플라본 글리코사이드가 6-24%가 함유된 은행잎 추출물 5-50중량부의 비율로 함유함을 특징으로 하는 발기부전치료용 조성물에 관한 것이다.The present invention relates to a composition for treating erectile dysfunction, comprising the amino acid L-arginine, ginseng extract, ginkgo biloba leaf extract, prickly pear extract, more specifically, L- arginine crystalline powder 5 to 200 parts by weight, ginseno 5-100 parts by weight of ginseng extract containing 5-30% of side, 5-50 parts by weight of prickly bark extract containing 0.05-0.45% of leutheroside and 6-24% of ginkgo flavone glycoside It relates to a composition for treating erectile dysfunction characterized in that it contains a ratio of 5-50 parts by weight of ginkgo biloba extract.
본 발명의 조성물은 부작용은 없으면서 발기부전에 탁월한 치료효과를 나타낸다.The composition of the present invention exhibits an excellent therapeutic effect without erectile dysfunction.
발기부전은 발기가 불완전하게 지속하거나 안되는 것으로서 정상적인 성생활을 불가능하게 하는 것으로서 동맥경화증, 고혈압, 당뇨병등과 같은 성인병과 같이 년령이 증가할 수 록 높은 빈도를 나타내었다.Erectile dysfunction is an incomplete or persistent erection, which impedes normal sexual life, and has a high frequency with increasing age, such as adult diseases such as atherosclerosis, hypertension, and diabetes.
그러나 최근에는 복잡한 현대사회의 특성 때문에 필연적으로 야기되는 스트레스, 불규칙한 생활습관, 만성적인 피로, 수면부족, 지나친 음주 및 흡연 등에 의하여 젊은층에서도 발기부전 환자의 발생빈도가 증가하고 있으며, 한국에서도 20세에서 79세 남성의 120만 정도가 발기부전환자로 추산되고 있어 사회적으로 심각한 문제를 야기하고 있는 실정이다.Recently, however, the incidence of erectile dysfunction patients is increasing in young people due to the inevitable stress, irregular lifestyle, chronic fatigue, lack of sleep, excessive drinking and smoking. It is estimated that about 1.2 million of 79-year-old men are erectile convertors, causing serious social problems.
이러한 정상적인 성생활을 방해하는 발기부전을 치료하고자 하는 다양한 약물들과 건강식품들이 개발되어 왔다.Various drugs and health foods have been developed to treat erectile dysfunction that interfere with the normal sex life.
이러한 약물들로서 첫째, 파파베린(papaverine), 아트로핀, 펜톨아민과 같이 성기에 직접 약물을 주입하는 주사제, 둘째, 니트로글리세린, 미녹시딜(minoxidil)등과 같이 성기에 도포하는 크림제 또는 겔제, 요힘빈, 펜톡시필린(Pentoxyfylline), 트라조돈(Trazodone), 플룩세틴(Fluoxetine), 실데나프릴(Sildenafril)등과 같은 경구용 제제 등이 있다.These drugs include: first, injections that inject drugs directly into the genitals, such as papaverine, atropine, phentolamine, and second, creams or gels applied to the genitals, such as nitroglycerin, minoxidil, yohimbine, pentoxy Oral preparations such as pentoxyfylline, trazodone, fluoxetine and sildenafril.
그러나 상기 약물들은 그 효과가 미미하거나 혹은 효과가 있다고하더라도 부작용이 심하여 의사의 엄격한 관리하에 투약되어야 한다는 문제점들이 있다. 특히 경구용 제제에 비하여 주사제는 환자가 성교 직전 직접 성기에 주사해야 하기 때문에 적당한 분위기를 필요로하는 성행위에 있어 지장을 줄 뿐 만 아니라 투여가 매우 곤란하다는 심각한 문제점이 있으며, 크림제 역시 환자가 성교 직전 약물을 성기에 도포해야 하기 때문에 주사제와 마찬가지로 적당한 분위기를 필요로하는 성행위에 있어 지장을 주고 있다.However, even if the effects are insignificant or effective, the side effects are severe and have to be administered under the strict control of a doctor. In particular, compared to oral preparations, injections have a serious problem that they are difficult to administer as well as difficult for sexual acts that require a suitable atmosphere because the patient must be injected directly into the genitals just before intercourse. Just before the drug must be applied to the genitals, as with injections, it interferes with sexual activity that requires a suitable atmosphere.
따라서 부작용이 없으면서도 효과가 충분히 나타나는 새로운 경구용 성분의 발기부전 치료제 개발이 절실히 요구되고 있다.Therefore, there is an urgent need for the development of a new oral erectile dysfunction treatment drug without side effects and fully effective.
본 발명자는 부작용은 없으면서 발기부전치료에는 높은 치료효과를 나타내는 경구용 성분을 찾고자 많은 연구를 수행한 결과, 종래에는 복합적으로 이용된 바 없는 아미노산 L-알기닌과 한약재료이면서 식품으로 사용되고 있는 인삼 추출물, 가시오가피 추출물, 은행잎 추출물의 혼합물을 복용할 경우 부작용은 없으면서 발기부전 치료에 탁월한 치료효과를 나타냄을 확인하여 본 발명을 완성하였다.The present inventors have conducted a number of studies to find oral ingredients that have a high therapeutic effect in the treatment of erectile dysfunction without side effects, as a result, ginseng extract which is used as a food while being an amino acid L-arginine and herbal medicine that has not been conventionally used in combination, When taking a mixture of thorny ogapi extract, ginkgo biloba extract has confirmed that it has an excellent therapeutic effect in the treatment of erectile dysfunction without any side effects, the present invention was completed.
따라서, 본 발명의 목적은 아미노산 L-알기닌,인삼 추출물, 가시오가피 추출물 및 은행잎 추출물을 함유함을 특징으로 하는 발기부전치료용 건강식품 또는 의약품용 조성물을 제공하는데 있다. 본 발명의 또 다른 목적은 아미노산 L-알기닌, 인삼 추출물, 가시오가피 추출물 및 은행잎 추출물을 함유함을 특징으로 하는 액제, 정제, 캅셀제, 연질캅셀제, 현탁제, 환제와 같은 경구용 제제를 제공하는데 있다.Accordingly, an object of the present invention is to provide a health food or pharmaceutical composition for erectile dysfunction characterized by containing the amino acid L- arginine, ginseng extract, prickly pear extract and ginkgo biloba extract. Still another object of the present invention is to provide oral preparations such as liquids, tablets, capsules, soft capsules, suspensions and pills containing amino acids L-arginine, ginseng extract, prickly pear extract and ginkgo biloba extract.
본 발명은 아미노산 L-알기닌, 인삼 추출물, 가시오가피 추출물, 은행잎 추출물을 함유하는 것을 특징으로 하는 발기부전치료용 조성물에 관한 것으로서, 보다 상세하게는 L-알기닌 결정성 분말 5∼200중량부, 진세노사이드 5-30%가 함유된 인삼 추출물 5-100중량부, 엘레우쎄로사이드 0.05-0.45% 함유된 가시오가피 추출물 5-50중량부 및 징코플라본 글리코사이드가 6-24% 함유된 은행잎 추출물 5∼50중량부의 비율로 함유함을 특징으로 하는 발기부전치료용 조성물에 관한 것이다.The present invention relates to a composition for treating erectile dysfunction comprising the amino acid L-arginine, ginseng extract, prickly pear extract, ginkgo biloba extract, and more specifically 5 to 200 parts by weight of L-arginine crystalline powder, ginseno 5-100 parts by weight of ginseng extract containing 5-30% of side, 5-50 parts by weight of prickly vinegar extract containing 0.05-0.45% of eluseroside and 5-50 parts of ginkgo leaf extract containing 6-24% of ginkgo flavone glycoside It relates to a composition for treating erectile dysfunction, characterized by containing in a proportion by weight.
이와같은 본 발명을 상세히 설명하면 다음과 같다,The present invention will be described in detail as follows.
L-알기닌은 아미노산의 일종으로서 산화질소를 생성시킴으로써 혈관내피세포에 작용하여 혈압을 강하하는 작용(Br. J. Pharmacol., 96, 418 (1989)), 면역증강작용(US 5576351), 혈소판에 작용하여 혈액응집 방지 (Pharmacol, Rev., 43, 109 (1991)), 뇌에 작용하여 신경전달을 매개하고(Proc. Natl. Acad. Sci. U.S.A., 86, 9030(1989)), 심장에 작용하면 관상동맥 확장작용을 하는 것이 알려져 있다. 특히 최근에는 발기부전에 치료효과가 있음이 밝혀졌다(Arch. It. Urol.,67, 321 (1995)) 본 발명은 L-알기닌을 결정성 분말 형태로 5∼200중량부로 사용한다. 본 발명의 L-알기닌은 시중에서 용이하게 구입할 수 있다.L-arginine is a type of amino acid that acts on blood vessel endothelial cells by producing nitric oxide, which lowers blood pressure (Br. J. Pharmacol., 96, 418 (1989)), immunopotentiation (US 5576351), platelets Acts to prevent blood coagulation (Pharmacol, Rev., 43, 109 (1991)), acts on the brain to mediate neurotransmission (Proc. Natl. Acad. Sci. USA, 86, 9030 (1989)), acts on the heart It is known that coronary artery dilation. In particular, it has recently been found to have a therapeutic effect on erectile dysfunction (Arch. It. Urol., 67, 321 (1995)). The present invention uses L-arginine in the form of crystalline powder at 5 to 200 parts by weight. L-arginine of the present invention can be easily purchased on the market.
인삼 추출물은 이미 잘 알려져 있는 바와 같이 각종 면역성을 증가시키고, 항암, 항당뇨, 노화방지, 항스트레스 및 위장기능 강화등 자양강장제로서의 효과가 알려져 있다. 이러한 인삼 추출물은 진세노사이드가 5-30%가 함유된 것을 5-100중량부 혼합하여 사용하며 본 발명에서는 시중에서 구입하여 사용하였다.Ginseng extract is known to increase the various immunity, as well known as anti-tumor, anti-diabetic, anti-aging, anti-stress and gastrointestinal function, such as nourishing tonic. This ginseng extract is used by mixing 5-100 parts by weight of ginsenosides containing 5-30% in the present invention was used commercially available.
가시오가피 추출물은 비특이성 저항력 증가, 혈당저하 작용, 근육골격근을 강하게 하는 강장제로 잘 알려져 있고 한방에서는 남자의 음위에 사용된다고 알려져 있는 무독한 약에 속하며(중약대사전) 한약재료 및 건강식품 원료로 사용되고 있다. 본 발명의 가시오가피 추출물은 일반적인 추출방법(물 또는 함수 알콜로 가열 추출)으로 제조한 것을 구입하여 사용할 수 있으며 엘레우쎄로사이드가 0.05-0.45% 함유된 고형분말을 5-50중량부를 혼합하여 사용한다. 은행잎 추출물은뇌 및 말초혈액순환 개선, 항천식, 항알레르기 및 신경계 강화효과가 있으며 본 발명에 사용된 은행잎 추출물은 시중에서 구입한 것으로서 징코풀라본 글리코사이드가 6-24% 함유된 것을 5-50중량부 혼합하여 사용한다.Prickly Pear Extract is a well-known tonic for increasing nonspecific resistance, hypoglycemic action, and strengthening muscle skeletal muscle. In oriental medicine, it is a poisonous medicine known to be used for men's stomach (Chinese medicine dictionary) and is used as a raw material of Chinese medicine and health food. . Prickly pear extract of the present invention can be purchased and used by the general extraction method (heat extraction with water or hydrous alcohol) and is used by mixing 5-50 parts by weight of solid powder containing 0.05-0.45% of eleurosides . Ginkgo biloba extract is effective in improving brain and peripheral blood circulation, anti-asthma, anti-allergic and nervous system. Ginkgo biloba extract used in the present invention is commercially available, containing 6-24% of ginkgo flavone glycoside 5-50 Mix by weight and use.
본 발명은 발기부전 치료에 효과가 있다고 알려진 L-알기닌과 가시오가피 추출물에 내피세포에서 L-알기닌에서 산화질소(Nitric oxide) 생성을 촉진하는 인삼추출물 중의 진세노사이드들과 (고려인삼학회 1999년 춘계총회 및 학술대회 초록집 23쪽) 말초혈관 혈액순환작용을 하는 은행잎추출물이 상승작용을 가지기 때문에 우수한 발기부전치료 효과를 나타내는 것이다. 특히 후술하는 실시예에서의 새로운 조성물의 발기부전 환자에 대한 발기 시간 연장 효과가 표 1에 나타낸 바와같이 본 발명의 조성물이 L-알기닌과 가시오가피 추출물 보다 인삼 추출물과 은행잎 추출물이 첨가된 조성물의 효과가 현저히 증가 된 것을 알 수 있으며 식품용으로 사용되는 원료들의 혼합이므로 부작용은 없어 매우 안전하다. 본발명과 같이 L-알기닌, 가시오가피 추출물, 인삼 추출물 및 은행잎 추출물이 혼합된 조성물을 이용하여 발기부전등의 성기능 장애를 치료하고자 한 경우는 없었으므로 본 발명의 조성물은 신규한 것이다.The present invention relates to the ginsenosides of ginseng extracts that promote the production of nitric oxide from L-arginine in endothelial cells to L-arginine and thorny ginseng extract known to be effective in the treatment of erectile dysfunction. 23) Ginkgo biloba extract, which has peripheral blood circulation, has a synergistic effect and shows excellent erectile dysfunction treatment effect. In particular, as shown in Table 1, the effect of the composition of the present invention is that the composition of the present invention has a ginseng extract and a ginkgo biloba extract added to the composition of the present invention than the L-arginine and thorn stem extract. It can be seen that it is significantly increased, and since it is a mixture of raw materials used for food, there is no side effect and it is very safe. As in the present invention, the composition of the present invention is novel because there is no case of treating sexual dysfunction such as erectile dysfunction by using a mixture of L-arginine, thorny ginseng extract, ginseng extract and ginkgo biloba extract.
한편 본 발명의 조성물에는 상기 주요 성분 이외에도 보조성분으로서 비타민 A, B군, C, E, 판토텐산, 엽산, 칼슘, 철, 아연, 마그네슘등의 성분을 혼합하여 사용하면 생체활성 효과를 보강할 수 있기 때문에 더욱 바람직하다.On the other hand, the composition of the present invention can enhance the bioactive effect by using a mixture of components such as vitamin A, B group, C, E, pantothenic acid, folic acid, calcium, iron, zinc, magnesium as auxiliary components in addition to the main components More preferred.
본 발명의 조성물은 공지의 첨가제등을 혼합하여 공지의 제조 방법에 따라 액제,현탁제, 정제, 캡슐제, 연질캡슐제, 환제, 과립제 등으로 제조하여 복용할 수 있으며, L-알기닌을 기준으로 1일 0.5g∼20g이 되도록 3∼4회 투여하는 것이 바람직하다.The composition of the present invention can be prepared by mixing known additives, etc. in the form of liquids, suspensions, tablets, capsules, soft capsules, pills, granules and the like according to known production methods, based on L-arginine It is preferable to administer 3-4 times so that it may become 0.5g-20g a day.
이때 액제 또는 현탁제등과 같은 제형으로 제조할 경우 미각을 돋구기 위하여 매실향, 레몬향, 파인애플향 또는 허브향과 같은 천연향료나 천연과즙, 클로르필린(chlorphyllin), 플라보노이드(flavonoid) 등의 천연색소 및 감미성분인 과당, 벌꿀, 당알콜, 설탕 등과 구연산, 구연산 나트륨과 같은 산미제를 혼합하여 사용할 수 있다.At this time, when prepared in a formulation such as a liquid or suspension, natural flavors such as plum, lemon, pineapple or herb, or natural pigments such as chlorphyllin and flavonoids to enhance the taste. And sweeteners such as fructose, honey, sugar alcohol, sugar, and the like, and may be used by mixing an acidulant such as citric acid and sodium citrate.
상술한 바와같이, 본 발명의 조성물은 종래의 발기부전 치료제와는 달리 널리 사용되어 왔던 천연 추출물 조성물로서 매우 안전하고 효과가 우수할 뿐 만 아니라 액제, 현탁제, 정제, 캡슐제, 연질캡슐제, 환제, 과립제 등으로 제조하여 복용할 수 있으므로 투여가 용이하고, 단순한 자양강장 효과 이외에도 발기부전 치료에 탁월한 효과가 있는 건강식품 조성물이다.As described above, the composition of the present invention is a natural extract composition that has been widely used in contrast to the conventional erectile dysfunction, as well as very safe and effective, as well as liquids, suspensions, tablets, capsules, soft capsules, Since it can be prepared by taking pills, granules and the like, it is easy to administer, and in addition to a simple nourishing tonic effect, it is a health food composition having an excellent effect in treating erectile dysfunction.
이하, 본 발명을 실시예에 의하여 상세히 설명하고자 하며 본 발명이 다음 실시예에 의하여 한정되는 것은 아니다.Hereinafter, the present invention will be described in detail by way of examples, and the present invention is not limited by the following examples.
이하의 참고예 및 실시예들에 사용한 가시오가피 추출물은 엘레우쎄로사이드가 0.4%, 인삼 추출물은 진세노사이드가 27%, 은행잎 추출물은 징코플라본 글리코사이드가 24% 함유된 것을 사용하였다.In the following reference examples and examples, the thorny ogapi extract used was 0.4% of eleuseroside, 27% of ginsenosides, and 24% of ginkgo flavone glycosides of ginkgo biloba extract.
[참고예 1] 캡슐제Reference Example 1 Capsule
L-알기닌 500g500 g of L-arginine
가시오가피추출물 100gPrickly Pear Extract 100g
옥수수 전분 350g350 g of corn starch
만니톨 50gMannitol 50g
상기 성분들을 잘 혼합하여 상법에 따라 1000캡슐을 제조하였다.The above ingredients were mixed well to prepare 1000 capsules according to the conventional method.
[실시예 1] 캡슐제Example 1 Capsule
L-알기닌 500g500 g of L-arginine
가시오가피추출물 100gPrickly Pear Extract 100g
인삼추출물 100gGinseng Extract 100g
은행잎추출물 3.5gGinkgo Leaf Extract 3.5g
옥수수 전분 300g300 g of corn starch
만니톨 50gMannitol 50g
상기 성분들을 잘 혼합하여 상법에 따라 1000캡슐을 제조하였다.The above ingredients were mixed well to prepare 1000 capsules according to the conventional method.
[실시예 2] 액제Example 2 Liquid
L-알기닌 5g5 g of L-arginine
인삼추출물 1.5gGinseng Extract 1.5g
가시오가피추출물 1.5gPrickly Pear Extract 1.5g
은행잎추출물 0.5gGinkgo Leaf Extract 0.5g
백설탕 15g15g white sugar
CMC sodium 5gCMC sodium 5g
에탄올 20ml20 ml of ethanol
상법에 따라 상기 혼합물에 정제수를 가하여 가용화하여 500ml로 액제화 하였다.Purified water was added to the mixture according to a conventional method to solubilize the solution to 500 ml.
[실시예 3] 현탁액Example 3 Suspension
은행 잎추출물 0.5gGinkgo Leaf Extract 0.5g
L-알기닌 5g5 g of L-arginine
인삼추출물 1gGinseng Extract 1g
가시오가피추출물 1.5gPrickly Pear Extract 1.5g
Hydroxymethyl cellulose 0.6gHydroxymethyl cellulose 0.6g
Avicel RC-581 0.2gAvicel RC-581 0.2g
D-sorbitol 10gD-sorbitol 10g
상기 혼합물에 정제수를 가하고 상법에 따라 현탁제 100ml를 제조하였다.Purified water was added to the mixture, and 100 ml of a suspension was prepared according to a conventional method.
[실시예4 ] 정제Example 4 Purification
L-알기닌 50g50 g of L-arginine
가시오가피추출물 4.5gPrickly Pear Extract 4.5g
인삼추출물 5gGinseng Extract 5g
은행잎추출물 1.5gGinkgo Leaf Extract 1.5g
아비셀 50gAvicel 50g
포비돈 1.5gPovidone 1.5 g
상기성분을 잘 혼합하고 상법에 따라 타정하여 100정을 만들었다.The above ingredients were mixed well and tableted according to the conventional method to make 100 tablets.
[실시예 5 ] 환제Example 5 Pill
L-알기닌 50g50 g of L-arginine
가시오가피추출물 10gPrickly Pear Extract 10g
인삼추출물 15gGinseng Extract 15g
은행잎추출물 1.5gGinkgo Leaf Extract 1.5g
벌꿀 15g15g honey
포비돈 5gPovidone 5g
상기성분들을 잘 혼합하고 상법에 따라 제환하여 50환을 만들었다.The above ingredients were mixed well and recirculated according to the conventional method to form 50 rings.
[실시예 6 ] 과립제Example 6 Granules
L-알기닌 70g70 g of L-arginine
가시오가피추출물 10gPrickly Pear Extract 10g
인삼추출물 15gGinseng Extract 15g
은행잎추출물 5gGinkgo Leaf Extract 5g
아비셀 PM101 150gAvicel PM101 150g
포비돈 5gPovidone 5g
상기 혼합물을 상법에 따라 압축성형하여 과립제를 제조하였다.The mixture was compression molded according to a conventional method to prepare granules.
[실시예 7] 연질캡슐제Example 7 Soft Capsule
L-알기닌 30g30 g of L-arginine
오가피추출물 10gOgapi Extract 10g
인삼추출물 10gGinseng Extract 10g
은행잎추출물 3.5gGinkgo Leaf Extract 3.5g
대두유 70g70g soybean oil
백납 5g5 g of lead
상기 성분을 잘 분산시키고 젤라틴 피제로 성형하여 연질캡슐제 100캡슐을 제조 하였다.The components were well dispersed and molded into gelatin skin to prepare 100 capsules of the soft capsule.
[실험예 1]Experimental Example 1
발기부전증을 가지고 있는 40세-60세의 건강한 남성 22명을 대상으로 무작위로 2군으로 나누어 비교예1, 실시예1에서 제조한 캡술제를 1회 2캡술 1일 3회 30일간 복용하고 발기 지속시간을 측정하여 표 1에 그 결과를 나타내었다22 healthy men aged 40-60 years old with erectile dysfunction were randomly divided into 2 groups and the capsulants prepared in Comparative Example 1 and Example 1 were taken once 2 caps 3 times a day for 30 days. The duration was measured and the results are shown in Table 1.
표1 : 발기부전증 개선효과Table 1: Improvement of Erectile Dysfunction
상기 실험예에 나타낸 바와 같이 본 발명의 조성물인 L-알기닌, 가시오가피 추출물, 인삼 추출물, 은행잎 추출물을 함유하는 조성물은 발기부전증 치료에 탁월한 효과를 나타낸다.As shown in the experimental example, the composition containing the composition of the present invention L-arginine, prickly ginseng extract, ginseng extract, ginkgo biloba extract shows an excellent effect in the treatment of erectile dysfunction.
또한 본 발명의 조성물들은 액제, 정제, 캡슐제, 연질캡슐제, 과립제, 현탁제, 환제로 제조하여 복용할 수 있다.In addition, the compositions of the present invention can be prepared by taking a liquid, tablets, capsules, soft capsules, granules, suspensions, pills.
Claims (3)
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| KR1019990028115A KR20010009653A (en) | 1999-07-12 | 1999-07-12 | Composition for treating sexual dysfunction |
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| KR1019990028115A KR20010009653A (en) | 1999-07-12 | 1999-07-12 | Composition for treating sexual dysfunction |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003094944A1 (en) * | 2002-05-10 | 2003-11-20 | Indena S.P.A. | Formulations useful in the treatment of male and female impotence |
| EP1406496A4 (en) * | 2001-06-01 | 2004-12-15 | Daily Wellness Company | Method and composition for enhancing sexual desire |
| WO2005025588A1 (en) * | 2003-09-15 | 2005-03-24 | Korea Research Institute Of Bioscience And Biotechnology | Extract of ogalpi, erectile dysfunction fanning healthy food and erectile dysfunction treating agent containing the same |
| WO2005049053A1 (en) * | 2003-11-20 | 2005-06-02 | Won Genesis Corporation | Composition comprising a magnesium compound and/or a magnesium saltfor improving sexual dysfunction |
| KR100799654B1 (en) * | 2006-07-10 | 2008-01-30 | 천지영농조합법인 | The pill and product method of ginseng |
| KR100850503B1 (en) * | 2006-12-19 | 2008-08-05 | 경희대학교 산학협력단 | Composition for improving erectile dysfunction and erection maintenance containing the extract of crude drug complex |
-
1999
- 1999-07-12 KR KR1019990028115A patent/KR20010009653A/en not_active Application Discontinuation
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1406496A4 (en) * | 2001-06-01 | 2004-12-15 | Daily Wellness Company | Method and composition for enhancing sexual desire |
| WO2003094944A1 (en) * | 2002-05-10 | 2003-11-20 | Indena S.P.A. | Formulations useful in the treatment of male and female impotence |
| US7361370B2 (en) | 2002-05-10 | 2008-04-22 | Indena S.P.A. | Formulations useful in the treatment of male and female impotence |
| US7438934B2 (en) | 2002-05-10 | 2008-10-21 | Indena S.P.A. | Formulations useful in the treatment of male and female impotence |
| WO2005025588A1 (en) * | 2003-09-15 | 2005-03-24 | Korea Research Institute Of Bioscience And Biotechnology | Extract of ogalpi, erectile dysfunction fanning healthy food and erectile dysfunction treating agent containing the same |
| US7718202B2 (en) | 2003-09-15 | 2010-05-18 | Korea Research Institute Of Bioscience And Biotechnology | Method for treating erectile dysfunction with acantopanax extract (ogalpi) |
| WO2005049053A1 (en) * | 2003-11-20 | 2005-06-02 | Won Genesis Corporation | Composition comprising a magnesium compound and/or a magnesium saltfor improving sexual dysfunction |
| KR100799654B1 (en) * | 2006-07-10 | 2008-01-30 | 천지영농조합법인 | The pill and product method of ginseng |
| KR100850503B1 (en) * | 2006-12-19 | 2008-08-05 | 경희대학교 산학협력단 | Composition for improving erectile dysfunction and erection maintenance containing the extract of crude drug complex |
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