KR100488511B1 - Health supplement including nature medicine ingredients and the composition thereof. - Google Patents
Health supplement including nature medicine ingredients and the composition thereof. Download PDFInfo
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- KR100488511B1 KR100488511B1 KR10-2002-0025656A KR20020025656A KR100488511B1 KR 100488511 B1 KR100488511 B1 KR 100488511B1 KR 20020025656 A KR20020025656 A KR 20020025656A KR 100488511 B1 KR100488511 B1 KR 100488511B1
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- vitamin
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- hydrochloride
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- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 16
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 239000003814 drug Substances 0.000 title description 5
- 239000004615 ingredient Substances 0.000 title 1
- 239000000843 powder Substances 0.000 claims abstract description 32
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 22
- 239000000284 extract Substances 0.000 claims abstract description 22
- CNNRPFQICPFDPO-UHFFFAOYSA-N octacosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCO CNNRPFQICPFDPO-UHFFFAOYSA-N 0.000 claims abstract description 22
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims abstract description 20
- 241001248610 Ophiocordyceps sinensis Species 0.000 claims abstract description 13
- 241000209020 Cornus Species 0.000 claims abstract description 12
- 229960002666 1-octacosanol Drugs 0.000 claims abstract description 11
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 11
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 11
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 11
- 229940029982 garlic powder Drugs 0.000 claims abstract description 11
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims abstract description 11
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 11
- 239000011718 vitamin C Substances 0.000 claims abstract description 11
- 239000009429 Ginkgo biloba extract Substances 0.000 claims abstract description 10
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000011787 zinc oxide Substances 0.000 claims abstract description 10
- 235000020686 ginkgo biloba extract Nutrition 0.000 claims abstract description 8
- 229940068052 ginkgo biloba extract Drugs 0.000 claims abstract description 8
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 10
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims description 8
- 235000014852 L-arginine Nutrition 0.000 claims description 7
- 229930064664 L-arginine Natural products 0.000 claims description 7
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- 108700024123 Arginases Proteins 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
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- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
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- 229940079593 drug Drugs 0.000 description 2
- 239000003797 essential amino acid Substances 0.000 description 2
- 235000004611 garlic Nutrition 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
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- GSPZXGHHFDORDC-GSVOUGTGSA-N (2R)-2-(diaminomethylideneamino)butanoic acid Chemical compound N(C(=N)N)[C@@H](C(=O)O)CC GSPZXGHHFDORDC-GSVOUGTGSA-N 0.000 description 1
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
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- 241000972773 Aulopiformes Species 0.000 description 1
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- 241000190633 Cordyceps Species 0.000 description 1
- 241000142975 Cornaceae Species 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
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- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
- 241000219745 Lupinus Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 102000007327 Protamines Human genes 0.000 description 1
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- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 241000736917 Trionyx Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 208000036029 Uterine contractions during pregnancy Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000003916 acid precipitation Methods 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013477 citrulline Nutrition 0.000 description 1
- 229960002173 citrulline Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- QNDQILQPPKQROV-UHFFFAOYSA-N dizinc Chemical compound [Zn]=[Zn] QNDQILQPPKQROV-UHFFFAOYSA-N 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000008157 edible vegetable oil Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000019688 fish Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 235000019514 herring Nutrition 0.000 description 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000037353 metabolic pathway Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
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- 230000009257 reactivity Effects 0.000 description 1
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- 235000019515 salmon Nutrition 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
- A23V2250/2124—Ginseng
Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
본 발명은 인체의 건강 유지 및 체력 강화에 유용한 새로운 조성의 건강보조식품에 관한 것으로서, 더욱 상세하게는 엘-아르기닌을 주성분으로 하고 그 외에 산화아연, 옥타코사놀, 비타민 C, 비타민 B1 염산염, 비타민 B2 및 비타민 B6 염산염과 생약재로서 동충하초 추출물, 산수유 추출물, 은행잎 추출물, 마늘 분말, 자라 분말을 함유하는 건강보조식품을 조성하여 성인이 400㎎용 캡슐에 담아 1회 2 내지 3 캅셀씩 1일 2 내지 3회 경구복용토록 함으로 인체의 건강 유지 및 강화에 유용한 새로운 조성의 건강보조식품을 제공할 수 있도록 한 것이다.The present invention relates to a dietary supplement of a new composition useful for maintaining the health of the human body and strengthening the physical strength, and more specifically, it is mainly composed of el-arginine, zinc oxide, octacosanol, vitamin C, vitamin B 1 hydrochloride, vitamin B 2 and vitamin B 6 hydrochloride and herbal supplement as a herbal medicine, Cordyceps sinensis extract, Cornus extract, Ginkgo biloba extract, Garlic powder, Grow powder to make health supplements for adults in 400mg capsules 2 to 3 capsules once a day 2 By oral administration three to three times to provide a health supplement food of a new composition useful for maintaining and strengthening the health of the human body.
Description
본 발명은 엘-아르기닌을 주성분으로 하고 그 외에 산화아연, 옥타코사놀, 비타민 C, 비타민 B1 염산염, 비타민 B2 및 비타민 B6 염산염과 여기에 생약재로서 동충하초 추출물, 산수유 추출물, 은행잎 추출물, 마늘 분말, 자라 분말을 혼합함으로서 생약재의 효능을 기대 할 수 있을 뿐만 아니라, 간편한 복용이 가능하게 하기 위한 것으로서 인체의 건강 유지 및 강화에 유용한 새로운 조성의 건강보조식품에 관한 것이다.The present invention is based on el-arginine, zinc oxide, octacosanol, vitamin C, vitamin B 1 hydrochloride, vitamin B 2 and vitamin B 6 hydrochloride, and as a herbal medicine Cordyceps sinensis extract, cornus extract, ginkgo biloba extract, garlic powder, By growing the powder to be able to expect the efficacy of the herbal medicines, as well as to enable easy taking of the health supplements of the new composition useful for maintaining and strengthening the health of the human body.
동충하초는 맥각균과에 속하는 동충하초균(Cordyceps sinensis (Berk.) Sacc.)이 인시목 곤충의 세끼벌레에 침입하여 만든 포자체를 벌레와 함께 말린 것으로, 기관지 확장 작용, 진정 작용, 최면 작용, 억균 작용이 있는 것으로 알려져 있으며, 한방에서는 폐와 신이 허하여 기침이 나면서 숨이 찬 데, 저절로 땀이 나는 데, 식은 땀, 음위증, 유정, 허리와 무릎이 시리고 아픈 데, 빈혈, 앓고 난 뒤 쓴다.Cordyceps sinensis is a dried spore produced by Cordyceps sinensis (Berk.) Sacc. It is known to be in the Chinese medicine, the lungs and the gods are coughing and breathing, coughing, spontaneous sweating, cold sweating, vulgaris, oil wells, cold and painful aches, anemia, and after writing.
산수유는 층층나무과에 속하며, 키나무인 산수유 나무(Macrocarpium officinale 또는 Cornus officinalis Sieb. et Zucc.)의 열매를 말린 것으로, 이뇨작용, 혈압을 잠시 낮추는 작용, 단백질 소화를 돕는 작용, 항암작용, 억균작용, 줄어든 백혈구 수를 늘리는 작용 등이 알려져 있으며, 한방에서는 신허로 허리와 무릎이 시큰시큰하며 아픈 데, 유정, 오줌을 자주 누는 데, 음위증, 어지러움증, 귀울림, 귀머거리, 절로 땀이 나는 데, 달거리가 많은 데 쓴다.Cornus is a member of the dogwood family, dried on the fruit of the key tree (Macrocarpium officinale or Cornus officinalis Sieb. Et Zucc.), Which acts as a diuretic, lowers blood pressure, helps digest proteins, anticancer, inhibits It is known to increase the reduced white blood cell count.In oriental medicine, the waist and knees are sore and painful, and the oil wells and pee are frequent, vulgaris, dizziness, tinnitus, deafness, and sweating. I spend a lot.
마늘은 억균작용, 감기바이러스에 대한 억제작용, 건위작용, 혈압낮춤작용, 동맥경화예방, 항암작용, 면역부활작용, 이뇨작용, 자궁수축작용이 있는 것으로 알려져 있다.Garlic is known to have bactericidal action, suppression of cold virus, health, blood pressure lowering, arteriosclerosis prevention, anticancer activity, immune reactivity, diuretic effect, and uterine contraction.
자라분말은 자라(Trionyx sinesis Wiegman)의 등딱지를 말린 것으로 한방에서는 음이 허하여 오후가 되면 열이 나면서 식은땀을 흘리는 데, 어린이 경간, 달거리가 없는 데, 징가(碑絨), 현벽, 몸이 여위는 데 쓴다.Zara powder is dried on the shell of Trionyx sinesis Wiegman, and in the oriental medicine, the sound is too low, and in the afternoon, the fever gets cold and there are no children's spans and moons. I am used to skinny.
그러나, 종래에는 엘-아르기닌, 산화아연, 옥타코사놀, 비타민 C, 비타민 B1 염산염, 비타민 B2 및 비타민 B6 염산염의 성분을 함유하는 인체의 건강 유지 및 강화용 건강보조식품은 있었으나, 생약재 특히, 동충하초 추출물, 산수유 추출물, 은행잎 추출물, 마늘 분말, 자라 분말을 혼합한 건강보조식품이 개발되어 있지 않아 이들 생약재의 효능을 기대 할 수 없었으며, 또한 생약재의 특유한 맛 때문에 복용에 어려움이 있었다.However, in the past, there was a dietary supplement for maintaining and strengthening the health of the human body containing the components of L-arginine, zinc oxide, octacosanol, vitamin C, vitamin B 1 hydrochloride, vitamin B 2 and vitamin B 6 hydrochloride. It was not possible to expect the efficacy of these herbal medicines because Cordyceps sinensis extract, Cornus extract, Ginkgo biloba extract, Garlic powder, Grow powder were not developed, and it was difficult to take because of the unique taste of herbal medicines.
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본 발명은 이와 같은 문제점을 감안한 것으로서, 본 발명의 목적은 엘-아르기닌을 주성분으로 하고 그 외에 산화아연, 옥타코사놀, 비타민 C, 비타민 B1 염산염, 비타민 B2 및 비타민 B6 염산염을 함유하며, 생약재로서 동충하초 추출물, 산수유 추출물, 은행잎 추출물, 마늘 분말, 자라 분말을 포함하는 인체의 건강 유지 및 강화에 유용한 새로운 조성의 건강보조식품을 제공하고자 하는 것이다.SUMMARY OF THE INVENTION The present invention has been made in view of the above problems, and an object of the present invention is to include el-arginine as a main ingredient and zinc zinc, octacosanol, vitamin C, vitamin B 1 hydrochloride, vitamin B 2 and vitamin B 6 hydrochloride, As a cordyceps extract, cornus extract, ginkgo biloba extract, garlic powder, growing powder to provide a health supplement of a new composition useful for maintaining and strengthening the health of the human body.
상기한 목적을 달성하기 위하여 본 발명은 엘-아르기닌 74.2중량%, 산화아연 2.0중량%, 옥타코사놀 1.0중량%, 비타민 C 1.0중량%, 비타민 B1 염산염 0.1중량%, 비타민 B2 0.1중량% 및 비타민 B6 염산염 0.1중량% 에 생약재로서 동충하초 추출물 분말 9.0중량%, 산수유 추출물 분말 8.0중량%, 은행잎 추출물 분말 0.7중량%, 마늘 분말 2.0중량%, 자라 분말 1.0중량%과 스테아린산 마그네슘 0.8중량%를 혼합하여 400㎎용 캡슐에 봉입하는 분말약제로 구성되는 인체의 건강 유지 및 강화에 유용한 새로운 조성의 건강보조식품을 제공한다.In order to achieve the above object, the present invention provides 74.2% by weight of el-arginine, 2.0% by weight of zinc oxide, 1.0% by weight of octacosanol, 1.0% by weight of vitamin C, 0.1% by weight of vitamin B 1 hydrochloride, 0.1% by weight of vitamin B 2 and vitamin B 6 hydrochloride 0.1% 9.0% by weight of Cordyceps sinensis extract powder as saengyakjae in weight, a mixture of Cornus officinalis extract powder, 8.0% by weight, 0.7% by weight of ginkgo extract powder, garlic powder, 2.0 wt%, growing powder 1.0 wt% and 0.8 wt% magnesium stearate It provides a health supplement food of a new composition useful for maintaining and strengthening the health of the human body consisting of powdered medicine encapsulated in a 400mg capsule.
본 발명에 따른 건강보조식품은 400㎎용 캡슐로 포장한다.Health supplement according to the present invention is packaged in a capsule for 400mg.
본 발명의 제제형태로는 연질캅셀제, 경질캅셀제, 산제, 정제, 과립제 등으로 제조할 수 있으며, 경질캅셀제가 바람직하다.As a preparation form of this invention, it can be manufactured with a soft capsule, a hard capsule, a powder, a tablet, a granule, etc., A hard capsule is preferable.
본 발명에 따른 경질캅셀 제형의 건강식품은 통상적인 제조방법에 따라 엘-아르기닌, 산화아연, 옥타코사놀, 비타민 C, 비타민 B1 염산염, 비타민 B2 및 비타민 B6 염산염과, 동충하초 추출물 분말, 산수유 추출물 분말, 은행잎 추출물 분말, 마늘 분말, 자라 분말, 첨가보조제인 스테아린산 마그네슘을 균질하게 혼합하여 경질캅셀에 충진함으로써 제조될 수 있다.The health food of the hard capsule formulation according to the present invention is el-arginine, zinc oxide, octacosanol, vitamin C, vitamin B 1 hydrochloride, vitamin B 2 and vitamin B 6 hydrochloride, Cordyceps sinensis extract powder, cornus extract Powder, ginkgo leaf extract powder, garlic powder, grow powder, can be prepared by homogeneously mixing the supplementary supplement magnesium stearate to fill the hard capsule.
본 발명의 조성물인 아르기닌은 화학식 C6H14N4402로된 염기성 아미노산으로 분자량 174.21이며, 물에 녹는다. E.슐체와 E.스타이거에 의하여 백화시킨 루피누스(콩의 일종)의 싹튼 것으로부터 단리 되었다. 그 질산염이 은(argent)처럼 흰색을 띠어 아르기닌이라고 이름을 붙였다. L-아르기닌은 단백질을 구성하는 아미노산의 하나로 존재하는데, 어류의 정자에 존재하는 단백질 프로타민에 속한다. 청어 ·연어 등에서는 구성 아미노산의 약 70 %가 아르기닌이다. 식물 종자 속에는 유리상태로도 존재한다. 아르기닌 잔기(殘基)는 그 구아니디노기(基)로 인해 강염기성을 나타낸다. 알칼리성으로 α-나프톨과 하이포아염소산을 작용시키면 특유한 빨간색을 띠므로 정량할 수 있다.Arginine, a composition of the present invention, is a basic amino acid of formula C 6 H 14 N 4 4 0 2 , having a molecular weight of 174.21, and soluble in water. It was isolated from the sprouting of the whitening lupine by E. Schulse and E. Steiger. The nitrate was white as argent and named arginine. L-arginine exists as one of the amino acids that make up protein, and belongs to the protein protamine in fish sperm. In herring and salmon, about 70% of the constituent amino acids are arginine. It is also in the free state in plant seeds. Arginine residues are strongly basic due to their guanidino groups. Alkaline action of α-naphthol and hypochlorous acid gives a distinctive red color and can be quantified.
또한 생체 내의 대사경로로서는 H.A.크레브스 등이 발견한 오르니틴회로[尿素回路]의 구성성분이며, 아르기나아제의 작용에 의하여 요소와 오르니틴으로 분해된다. 시트룰린과 아스파라긴산으로부터 생성된다. 성인에게는 비필수아미노산이지만 유아에게는 필수아미노산이다. 암모니아나 대량의 아미노산의 독작용(毒作用)에 대하여 보호하는 작용이 있다. 뇌에는 아르기나아제가 존재하며, ｒ-구아니디노부티르산의 전구체인 아르기닌의 양을 조절하고 있다. 무척추동물에서는 아르기닌인산의 형태로 포스파겐으로서 근육의 수축에 중요한 역할을 하는 것 외에, 특이한 구아니딘염기(마그마틴 ·옥토핀)의 전구체로서 널리 존재하는 것으로 알려져있다.In addition, as a metabolic pathway in vivo, it is a component of the ornithine cycle discovered by H.A.Crebs and others, and is decomposed into urea and ornithine by the action of arginase. It is produced from citrulline and aspartic acid. Non-essential amino acids for adults but essential amino acids for infants. It protects against the poisoning effect of ammonia and large amounts of amino acids. Arginase is present in the brain and regulates the amount of arginine, a precursor of r-guanidinobutyric acid. In invertebrates, in the form of arginine phosphate, it is known to play an important role in the contraction of muscle as a phosphogen, and is widely present as a precursor of a specific guanidine base (magmatin-octopine).
이러한 L-아르기닌을 조성물로 하는 본 발명을 하기의 실시예를 통해 보다 상세하게 설명하기로 하나, 본 발명은 하기한 설명에 반드시 한정되는 것은 아니다. Although the present invention using the L-arginine as a composition will be described in more detail through the following examples, the present invention is not necessarily limited to the following description.
<실시예 1><Example 1>
본 발명의 동충하초, 산수유 및 은행잎은 각각 20 내지 60% 에탄올로 통상적인 방법에 따라 추출, 여과, 감압농축, 건조하여 제조하여 각각의 추출물 분말을 제조한다. 자라는 산 침전, 중화, 세척 건조한 뒤, 식용 유지에 넣어 100℃ 이상의 온도로 1 시간동안 가열하고, 건조시켜 분쇄함으로서 분말을 제조할 수 있다. 마늘은 음건 한 뒤 분쇄하여 분말을 제조할 수 있다.Cordyceps sinensis, cornus oil and ginkgo biloba leaves of the present invention are prepared by extraction, filtration, concentrated under reduced pressure, and dried according to a conventional method with 20 to 60% ethanol, respectively, to prepare respective extract powders. After growing the acid precipitation, neutralization, washing and drying, put into edible oils and fats for 1 hour, heated to a temperature of 100 ℃ or more, and dried to pulverize to prepare a powder. Garlic may be dried and then ground to produce a powder.
이렇게 분말화한 생약재들은 상기 다른 약제와 혼합 봉입한다. 즉, 엘-아르기닌 74.2중량%, 산화아연 2.0중량%, 옥타코사놀 1.0중량%, 비타민 C 1.0중량%, 비타민 B1 염산염 0.1중량%, 비타민 B2 0.1중량%, 비타민 B6 염산염 0.1중량% 및 생약재로 동충하초 추출물 분말 9.0중량%, 산수유 추출물 분말 8.0중량%, 은행잎 추출물 분말 0.7중량%, 마늘 분말 2.0중량%, 자라 분말 1.0중량%, 비율로 균질하게 혼합하는데, 이때, 약제의 유동성을 높이기 위하여 스테아린산 마그네슘 0.8중량%를 혼합하여 균질하게 혼합 한 후 400㎎용 캡슐에 봉입한다.The powdered herbal medicines are mixed and encapsulated with the other drugs. That is, 74.2% by weight of el-arginine, 2.0% by weight of zinc oxide, 1.0% by weight of octacosanol, 1.0% by weight of vitamin C, 0.1% by weight of vitamin B 1 hydrochloride, 0.1% by weight of vitamin B 2, 0.1% by weight of vitamin B 6 hydrochloride and herbal medicines Cordyceps sinensis extract powder 9.0% by weight, cornus extract powder 8.0% by weight, ginkgo biloba extract powder 0.7% by weight, garlic powder 2.0% by weight, grow up powder 1.0% by weight, mixing homogeneously in proportion, at this time, to increase the fluidity of the drug stearic acid 0.8% by weight of magnesium is mixed and mixed homogeneously and then encapsulated in a capsule for 400 mg.
제제예 1 : 경질캅셀제의 제조Formulation Example 1 Preparation of Hard Capsule
본 발명에 의한 건강보조식품의 조성물은 실시예 1을 가지고 통상의 경질캅셀 제조방법에 따라 제조하였다. 제제예에서 스테아린산 마그네슘을 활태제로 사용하여 내용물의 최종 중량을 400㎎으로 하였다.The composition of the dietary supplement according to the present invention was prepared according to the conventional hard capsule manufacturing method with Example 1. In the formulation example, magnesium stearate was used as a lubricating agent and the final weight of the content was 400 mg.
엘-아르기닌 --------------------- 296.8㎎L-arginine --------------------- 296.8mg
동충하초 추출물 분말 ------------- 36.0㎎Cordyceps Sinensis Extract Powder ------------- 36.0mg
산수유 추출물 분말 --------------- 32.0㎎Cornus Extract Powder --------------- 32.0mg
마늘 분말 ------------------------ 8.0㎎Garlic Powder ------------------------ 8.0mg
산화 아연 ------------------------ 8.0㎎Zinc Oxide ------------------------ 8.0mg
옥타코사놀 ----------------------- 4.0㎎Octacosanol ----------------------- 4.0mg
비타민 C ------------------------- 4.0㎎Vitamin C ------------------------- 4.0mg
자라 분말 ------------------------ 4.0㎎Grow powder ------------------------ 4.0mg
은행잎 추출물 분말 --------------- 2.8㎎Ginkgo Leaf Extract Powder --------------- 2.8mg
비타민 B1 염산염 ----------------- 0.4㎎Vitamin B 1 Hydrochloride ----------------- 0.4mg
비타민 B2 ------------------------ 0.4㎎Vitamin B 2 ------------------------ 0.4mg
비타민 B6 ------------------------ 0.4㎎Vitamin B 6 ------------------------ 0.4mg
상기와 같이 제제된 본 발명에 따른 건강보조식품은 400㎎용 캡슐을 1회 2 내지 3 캅셀씩 1일 2 내지 3회 경구 복용하는 것이 바람직하다.The health supplement according to the present invention prepared as described above is preferably administered orally 2 to 3 capsules once a day for 2-3 capsules for 400mg.
상기 경구복용하는 건강보조 식품은 400㎎용 캡슐을 1회 2 내지 3 캅셀씩 1일 2 내지 3회로 한정하는 것은 아니나 건강보조식품으로 복용하는 것이므로 성인이 1일 4캅셀이하로 복용시에는 그 효과가 미미하므로 적어도 4에서 9캅셀은 복용하는 것이 바람지하며 1일 9캅셀 이상은 영양분이 배설되어 불필요한 복용이 되므로 400㎎용 캡슐을 1회 2 내지 3 캅셀씩 복용하는 것이 바람직한 것으로 판단된다.The oral supplement foods are not limited to two or three capsules of 400mg once or twice a day, but as a dietary supplement is to take as a dietary supplement 4 adults less than 4 capsules per day the effect Because it is insignificant, at least 4 to 9 capsules are recommended to be taken, and more than 9 capsules per day, nutrients are excreted, which is unnecessary to take, so it is considered that it is desirable to take 2 to 3 capsules once for 400 mg capsules.
이상에서와 같이 본 발명에 의한 건강보조식품은 엘-아르기닌을 주성분으로 하며 그 외에 산화아연, 옥타코사놀, 비타민 C, 비타민 B1 염산염, 비타민 B2 및 비타민 B6 염산염을 함유하는 건강식품과 여기에 생약재로서 동충하초 추출물, 산수유 추출물, 은행잎 추출물, 마늘 분말, 자라 분말을 혼합함으로써 생약재의 효능을 기대할 수 있을 뿐 아니라, 간편한 복용이 가능하게 하기 위한 것으로서 인체의 건강 유지 및 강화에 유용한 것이다.As described above, the health supplement food according to the present invention is a health food containing el-arginine as a main ingredient and zinc oxide, octacosanol, vitamin C, vitamin B 1 hydrochloride, vitamin B 2 and vitamin B 6 hydrochloride, and As a herbal medicine, Cordyceps sinensis extract, Cornus extract, Ginkgo biloba extract, Garlic powder, Grow powder can be expected not only to expect the efficacy of the herbal medicine, but also to enable easy administration as it is useful for maintaining and strengthening the health of the human body.
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| WO2023086647A1 (en) * | 2021-11-12 | 2023-05-19 | Rekemend Llc | Nutraceutical mushroom compositions and methods of treatments using same |
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| KR100794383B1 (en) * | 2006-08-01 | 2008-01-15 | 한국식품연구원 | Garlic tablet and garlic manufacturing method containing garlic extract |
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