JP2971383B2 - Oral graying agent - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an orally administrable or orally administrable gray hair blackening agent capable of darkening gray hair or inhibiting the progress of graying.

[0002]

2. Description of the Related Art In hair, the portion of the hair that comes out of the skin is called the hair shaft, and the portion inside the skin is called the hair root. The tip (proximal end) of the hair root is a hair bulb, and the lower surface is a hair nipple, which produces hair. When the hair root is sliced, there is a medulla in the center, and the fur is covered by the medulla. The cortex is composed of spindle-shaped keratinocytes and has melanin granules. Depending on the quality, size and amount of the melanin, various hair colors can be produced. Gray hair is hair from which the melanin granules have disappeared. (“Cosmetic Science”, published by Nanzando Co., Ltd., published: 13th edition, January 10, 1978, see pages 5-7)

[0003] In general, the skin deteriorates with aging, and even in the case of hair, hair loss and whitening occur. It is said that it is better to ingest seaweeds such as kelp for preventing gray hair.

[0004] In recent years, various foods have become widespread as health foods. Among them, there are cuttlefish (squid ink) and ginkgo biloba extract related to the present invention.

[0005] Foods and cooking methods using squid ink (squid ink) include, for example, bread with squid water, udon with squid water, ramen with squid water, salty squid with squid water, spaghetti sauce with squid water, pasta sauce with squid water, squid porridge, squid porridge There are soups.
It has also been reported that Ikasumi has a pharmacological effect such as a hemostatic action, a tonic action, and an anti-ulcer action.

Ginkgo biloba contains flavonoids, and the extract of ginkgo biloba is said to be effective in preventing arteriosclerosis, improving poor circulation, preventing adult diseases, and the like.
("Effect of ginkgo biloba", published by Health Research Institute,
Issued on: August 30, 1991, reprint)

[0007] The effectiveness of ginkgo biloba extract and its application are described in “Fragrance Journal Extra Edition N
o. 6 (1986), Cosmetic Plant Science-Development and Effective Utilization of Plant Ingredients-, published by Fragrance Journal, published on May 1, 1986, pp. 297-299. It is stated that the component from has a vasodilating action, a blood flow increasing action, a cosmetic treatment action, a plaque formation preventing action, and the like.

Recently, an agent for improving the hair growth function using sepiomelanin extracted from the ink of cephalopods such as true squid has been proposed (JP-A-6-298656).
It is stated that white hair can be improved to black hair by external or internal use.

[0009]

It is said that it is better to ingest seaweed than usual in the private sector in order to prevent gray hair, but ingestion of seaweed is certainly preferable from the viewpoint of nutritional balance. Effectiveness for prevention of the disease has not been confirmed.

[0010] At present, an extremely wide variety of health foods are sold, but it seems that there are no foods or pharmaceuticals capable of darkening gray hair.

Several patent applications have been filed for the use of cosmetics to which certain plant extracts have been added to darken gray hair, but the effect has not been as expected.

In the end, there is no effective means for preventing gray hair, and in the case of gray hair, there is no other way but to dye the hair with a hair dye.

The above-mentioned Japanese Patent Application Laid-Open No. 6-29 recently proposed
In the agent for improving hair growth function disclosed in 8656,
It is stated that for the extraction of sepiomelamine from black ink, a polymer membrane used for extracting fruit juice and the like is used. This operation is considered to correspond to an operation of concentrating fruit juice to about 2 to 4 times using an acetylcellulose membrane or the like.

[0014] However, the fact that eating squid as a food has been practiced for a long time has not been heard of reports that the gray hair has turned black. The effect of improving white hair has not been confirmed just by ingesting the product), and the idea that black hair or black pigment with high concentration of melamine, if taken or used externally, would make the hair black would be achieved. If it is done, then, from the background that the problem of graying has been resolved so far and there was no need for hair dyeing, etc. It's hard to believe that you can just turn gray hair into black hair. The composition of the hair tonic shown in the examples also has an unusually high concentration, such as the addition of 10% by weight of dry powder of sepiomelamine to the composition containing as much as 10% by weight of menthol. It is unlikely to be a composition. (By the way, 106-1 of "Latest Cosmetic Science-Revised and supplemented-edited by Japan Cosmetic Engineers Association, published by Yakuji Nippo, published on June 6, 1988, revised and supplemented version")
According to the hair tonic composition on page 07, the proportion of menthol is 0.1%).

[0015] For many people, graying with age is a major problem, and even relatively young people may become gray. If it could be darkened by ingestion or oral administration, its utility would be enormous.

An object of the present invention is to provide an oral-type whitening agent capable of blackening gray hair or suppressing the progress of graying in such a background and having no side effects. It is.

[0017]

SUMMARY OF THE INVENTION One object of the present invention is to provide a single or multi-drug oral graying agent consisting of cuttlefish (A) and ginkgo biloba extract (B). is there.

Another gist of the present invention is a single or multi-drug oral graying agent comprising squid (A), ginkgo biloba extract (B) and calcium agent (C). Things.

[0019]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail.

As the squid (A), a squid collected from a squid ink bag is preferably dried and powdered in consideration of storability and handleability. The squid thus obtained is in the form of powder, in the form of soft capsules or hard capsules in which the powder is mixed with edible oil and pasted and then encapsulated with gelatin or the like, or the powder is lactose or sorbit. It is used in the form of tablets which are mixed with excipients or binders, such as starch, starch and gums, and tableted, and further in the form of tablets coated with shellac or sucrose.

As the ginkgo leaf extract (B), for example, an extract of ginkgo leaves extracted with water, an organic solvent or a mixed solvent of water and an organic solvent, or a powdered extract thereof is used.

As the calcium agent (C), for example, calcium lactate, whey calcium, shell calcium, fish bone calcium, edible bovine bone powder and the like are used.

In the present invention, squid (A) and ginkgo biloba extract (B) are used in combination, and more preferably a calcium agent (C) is used in combination therewith. Significant graying action of gray hair cannot be expected by using only the hair thinner (A), the ginkgo biloba extract (B) and the calcium agent (C) alone.

The dosage form may be a one-part dosage form in which the two of (A) and (B) are mixed, or a two-part dosage form in which the respective components are combined without being mixed. Further, a single-drug type in which the three of (A), (B), and (C) are mixed may be used, and a two-drug type in which a mixture of the two of them and the remaining one are combined, or A three-drug type in which these components are combined without being mixed may be used.

Each of the components constituting the blackening agent of the present invention comprises:
All of them are used as foods and health foods, so they have no side effects. The intake or dosage can be selected from a wide range, but usually it is an adult per day,
Is about 40 to 700 mg, especially about 60 to 500 mg, and Ginkgo biloba extract (B) is about 10 to 300 mg, especially about 20 to 2 mg.
The standard is often about 00 mg and the calcium agent (C) is about 0 to 600 mg, especially about 20 to 600 mg.

The graying agent of the present invention comprising the above-mentioned components is used for other components commonly used in foods and pharmaceuticals, for example, isolates from other natural animals and plants, vitamins, higher polyunsaturated fatty acids (DHA and EPA, etc.), lubricants, surfactants,
It may contain salts, preservatives, flavors and the like.

The graying agent of the present invention is useful as a food (including nutritional supplements and seasonings) or a pharmaceutical.

<Action> Squid (A), Ginkgo biloba extract
(B) and the calcium agent (C) alone did not show any significant blackening effect, but when combined with squid (A) and ginkgo biloba extract (B), a significant blackening effect was observed. And squid (A), ginkgo biloba extract
When the three agents (B) and calcium agent (C) are used in combination, a more reliable blackening action of gray hair is recognized.

[0029]

The present invention will be further described with reference to the following examples.

Example 1 <Preparation of blackening agent for gray hair> Squid collected from a squid ink bag was sterilized and powdered as usual, ginkgo biloba extract powder, and whey calcium as an example of a calcium agent. Powder and beef bone powder were tableted using an excipient, a binder, a lubricant and the like in a conventional manner. The surface was coated with shellac and further coated with sugar to give tablets.

The weight of each tablet was about 0.5 g, the amount of cuttlefish contained in the tablet was about 25 mg, the amount of ginkgo biloba extract was about 15 mg, and the amount of calcium was about 20 mg.

The tablets containing the cuttlefish, ginkgo biloba extract and calcium agent thus obtained may be taken with water or hot water, for example, about 6 tablets per day.

The squid itself has a bad smell and may not be preferred by some people. However, since the squid is tableted and coated as described above, it is odorless.
The mouth does not turn black. Ginkgo biloba extract itself has bitterness, but since it is also a tablet coated as described above, bitterness is not felt when taking it. In addition, the smell of cuttlefish and the bitterness of ginkgo biloba extract are sometimes preferred by experienced people. .

<Case 1> Age: 45, gender: male, occupation: pharmacist. Initial gray hair degree: about 70%. When she took 5 to 6 tablets daily, she noticed that her gray hair had decreased after about one and a half months.

<Case 2> Age: 31 years old, gender: male, occupation: company employee. Initial degree of gray hair: about 60%. Although she had a lot of gray hair since childhood, she took the above tablets 5-6 daily.
When she was taking the granules, her wife began to point out that her hair had turned black since about three months. Certainly, gray hair has turned light brown and white hair has decreased. Five months after taking it, gray hair became inconspicuous in everyone's eyes, as if using a hair dye.

<Case 3> Age: 55 years old, gender: male, occupation: pharmacist. Initial gray hair degree: about 70%. When six tablets of the above tablets were taken every day, others noticed that the gray hair was significantly reduced after three months. I also noticed that my chest hair was black. People around me told me that my hair had increased, and when I looked carefully, I noticed that my hair had definitely increased.

<Case 4> Age: 55 years old, gender: male, occupation: pharmacist. Initial gray hair degree: about 70%. When the above tablet was continuously taken twice a day (three tablets at a time) for 7 months, the following symptoms were observed. With regard to gray hair, it has been said that the amount of white hair has decreased from family members since taking a bottle (about 40 days). If she continued after that, she would have less white hair to admit both herself and others.

<Case 5> Age: 58, gender: male, occupation: professor at university. Initial degree of gray hair: about 80%. When she continued to take three tablets of the above tablet twice a day, she noticed that her gray hair became black about one month later.
After that, when she continued, she clearly had less gray hair.

<Comparative Example 1> Squid collected from a squid ink bag was sterilized, powdered as usual, and tableted as usual using excipients, binders, lubricants and the like. The surface was coated with shellac and further coated with sugar to give tablets. The weight per tablet is about
The amount was 0.5 g, and the amount of cuttlefish contained in the tablet was about 25 mg.

Although this tablet was provided to a large number of people as a health food, there was no report that the gray hair had been improved.

Comparative Example 2 Ginkgo biloba extract powder was tableted using an excipient, a binder, a lubricant and the like in a conventional manner. The surface was coated with shellac and further coated with sugar to give tablets. The weight per tablet was about 0.5 g, and the amount of ginkgo biloba extract contained in the tablet was about 15 mg.

Although this tablet was also provided to a large number of people as a health food, there was no report that the gray hair had been improved.

Example 2 A powder obtained by pulverizing a thinning agent in a usual manner was kneaded into a paste with olive oil, and then a rugby ball-shaped soft capsule having gelatin as an outer shell was prepared. The weight per soft capsule was about 0.5 g, and the amount of cuttlefish contained in one soft capsule was 120 mg.

On the other hand, the powder of ginkgo biloba extract was made into tablets as usual, and shellac-coated. The weight per tablet was about 0.25 g, and the amount of ginkgo biloba extract contained in one tablet was about 15 mg.

The soft capsule containing squid and the tablet containing ginkgo biloba extract thus obtained are, for example, 1
About 3 and 6 tablets per day may be taken with water or hot water.

<Case> A large number of men and women were asked to take about 6 of the above tablets daily, and there were many reports that their physical condition had improved. Although the number of recipients with gray hair was uncertain, there were considerable reports of improved gray hair.

[0047]

The oral graying agent of the present invention can darken gray hair or suppress the progress of whitening, and has no side effects irrespective of ingestion or dosage. In addition, ingestion of squid (A) and ginkgo biloba extract (B) (furthermore, calcium agent (C)) has an effect of promoting health.

──────────────────────────────────────────────────続 き Continued on the front page (58) Field surveyed (Int.Cl. ⁶ , DB name) A61K 35/78 A61K 35/56

Claims (3)

(57) [Claims] 1. Squid (A) and Ginkgo biloba extract (B)
Or a multiple-drug oral graying agent. 2. A single or multi-drug oral graying agent comprising a cuttlefish (A), a ginkgo biloba extract (B) and a calcium preparation (C). 3. The method according to claim 1, which is a food or a pharmaceutical.
The oral graying agent according to the above.