CN105267080A - Folic acid toothpaste and preparing method of folic acid toothpaste - Google Patents
Folic acid toothpaste and preparing method of folic acid toothpaste Download PDFInfo
- Publication number
- CN105267080A CN105267080A CN201410309889.1A CN201410309889A CN105267080A CN 105267080 A CN105267080 A CN 105267080A CN 201410309889 A CN201410309889 A CN 201410309889A CN 105267080 A CN105267080 A CN 105267080A
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- Prior art keywords
- folic acid
- toothpaste
- volatile oil
- mass fraction
- dispersed
- Prior art date
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- 229940034610 toothpaste Drugs 0.000 title claims abstract description 64
- 239000000606 toothpaste Substances 0.000 title claims abstract description 64
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 title claims abstract description 58
- 229960000304 folic acid Drugs 0.000 title claims abstract description 58
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 51
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 40
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Landscapes
- Cosmetics (AREA)
Abstract
The invention provides folic acid toothpaste and a preparing method of the folic acid toothpaste. The folic acid toothpaste is prepared from the following ingredients in percentage by mass: 0.005 percent to 0.1 percent of folic acid, 0.01 percent to 10 percent of fresh ginger volatile oil or extraction liquid and 0.01 to 10 percent of perilla leaf volatile oil or extraction liquid. The ingredients are matched with common auxiliary materials used for preparing the toothpaste to prepare the toothpaste according to a certain toothpaste preparation process. The invention also provides the preparing method of the folic acid toothpaste. The folic acid toothpaste has the effects of reliving the gingivitis and gingival bleeding in the gestational period and the postpartum period, and belongs to compound toothpaste which is particularly applicable to prevention of nausea and vomit due to tooth brushing in the gestational period.
Description
Technical field
The invention belongs to household chemicals field, relate to a kind of new toothpaste, it uses crowd to be trimester of pregnancy and puerperal women, one that involved in the present invention is can effectively alleviate trimester of pregnancy and puerperal gingivitis, gingival hemorrhage, and the compound mormula folic acid toothpaste that trimester of pregnancy can be prevented to brush teeth cause nausea, vomit; The present invention also relates to the preparation method of this toothpaste simultaneously.
Background technology
Toothpaste is one of important dental care products keeping oral health in life, and toothpaste is the material being used from teeth surfaces with toothbrush one, has very long history.Along with the development of science and technology, technological equipment update and perfect, quality and the class of product improve constantly, present toothpaste variety is by single clean type toothpaste, develop into great variety of goods, diverse in function, the Mobyneb toothpaste of up to a hundred brands, meets the needs of dissimilar consumer.Toothpaste type common in the market has fluoride dental cream, Chinese herbal toothpaste, antiallergic toothpaste, zinc citrate toothpaste, children's toothpaste etc.
Trimester of pregnancy is women's important stage in life, is also the important period safeguarding oral health.Due to the flip-flop of trimester of pregnancy internal milieu, the existence of pregnant front oral cavity underlying diseases in addition, the change of health body weight and hormonal readiness after gestation, the ill chance of the oral disease of trimester of pregnancy women is increased, and the daily health caring in pregnancy period oral cavity seems and is even more important.
Trimester of pregnancy gingivitis be trimester of pregnancy occur the peculiar symptom in oral cavity, also referred to as pregnancy gingivitis.According to statistics, conceived women's incidence rate about 50%.Clinical symptoms is dental pattern gingivitis, and especially interdental papilla is swollen has obviously, and color is dark red, shinny, soft, and severe patient may have ulcer and pseudomembrane to be formed.And have slight pain to occur.Pregnancy gingivitis generally occurs for 2 to 4 months after pregnancy, and childbirth then disappears.If existing gingivitis exists before gestation, then symptom can be made to aggravate.Therefore, there is the anemia of pregnant woman of advanced symptoms, oral health care must be carried out in time.
In addition, women more than half is about had also to be a great problem of puzzlement pregnant women at the vomiting during pregnancy that early pregnancy occurs, vomiting during pregnancy is except outside the Pass having with neuroendocrine, spirit and the intrinsic factor such as social, and the extrinsic factor such as the throat irritation also brought with toothpaste foam when brushing have very important relation.
In sum, invention one can effectively alleviate trimester of pregnancy and puerperal gingivitis, gingival hemorrhage, and the compound mormula folic acid toothpaste that trimester of pregnancy can be prevented to brush teeth cause nausea, vomit, well can solve the oral health issue in trimester of pregnancy and puerperal.
Folic acid (FolicAcid) be also FA, is a kind of water soluble vitamins, is present in little of virus, antibacterial, greatly in all biosystems of the mankind, obtains, therefore be called folic acid because extracting from the leaf of spinach at first.Folic acid is the necessary material of human body when utilizing sugar and aminoacid, is the necessary material of body cell Growth and reproduction.
Folic acid works with the form of tetrahydrofolic acid in vivo, and tetrahydrofolic acid participates in synthesis and the conversion of purine nucleic acid and pyrimidine nucleotide in vivo.Folic acid plays the part of important role in manufacture nucleic acid (ribonucleic acid, DNA (deoxyribonucleic acid)).Folic acid helps the metabolism of protein, and jointly promotes erythrocytic generation and maturation with vitamin B12, is to manufacture the indispensable material of erythrocyte.
The synthesis of folic acid to the merisis of cell and nucleic acid, aminoacid, protein plays an important role.Human body lacks folic acid can cause erythrocytic exception, the increase of immature cell, anemia and leukopenia.Folic acid is the indispensable nutrient of embryo growth and development.Anemia of pregnant woman lacks folic acid and likely causes occurring under-weight, harelip, heart defect etc. during fetal birth.If lack folic acid at conceived in 3 months, fetal neural tube developmental defect can be caused, and cause deformity.Therefore, prepare conceived women, can just start to take 400 folic every day before pregnancy.
Clinical research finds, pregnancy duration uses and also can reduce trimester of pregnancy gingival index containing the dental care products of folic acid, pre-preventing parodontitis, alleviates gingival hemorrhage, can obviously improve trimester of pregnancy gums healthy.
Chinese medicine Rhizoma Zingiberis Recens is the fresh rhizome of zingiber ZingiberofficinaleRosc..Autumn, season in winter two excavate, removing fibrous root and silt.Rhizoma Zingiberis Recens has the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, effect of preventing phlegm from forming and stopping coughing.For anemofrigid cold, gastrofrigid vomiting, cold-phlegm is coughed.The traditional Chinese medical science have cloud " Rhizoma Zingiberis Recens is patient suffering from habitual vomiting panacea " ", can apply separately, treatment gastrofrigid vomiting, also can control gastropyretic vomiting, coordinates the Rhizoma Pinelliae, Caulis Bambusae In Taenia, Rhizoma Coptidis is equivalent uses.Rhizoma Zingiberis Recens energy solving toxin of fish and crab, alone or join Folium Perillae with use.
Folium Perillae is the dried leaves (or band twig) of labiate Folium Perillae Perillafrutescens (L.) Britt.Gather when summer, branch and leaf were luxuriant, removing impurity, dries.The many shrinkages of this product blade are curling, broken broken, in oval after complete person flattens, and long 4 ~ 11cm, wide 2.5 ~ 9cm.The long point of tip or anxious point, basal circular or wide wedge shape, edge tool crenature.Two sides purple or upper surface green, lower surface purple, dredge raw canescence hair, lower surface has the glandular scale of most concave point shape.Long 2 ~ the 7cm of petiole, purple or purple green.Matter is crisp.Band twig person, the diameter 2 ~ 5mm of branch, purple green, there is marrow in the middle part of section.Gas delicate fragrance, taste is micro-pungent.There is the cold expelling that induces sweat, effect of relieving QI stagnancy in the stomach.For anemofrigid cold, cough vomiting and nausea, vomiting during pregnancy, fish Eriocheir sinensis is poisoning.Folium Perillae can fall apart exterior cold, and diaphoresis power is comparatively strong, for wind and cold table disease, seeing aversion to cold, heating, the disease such as lossless, often joining Rhizoma Zingiberis Recens with using; Having the stagnation of QI concurrently as shown disease, having to be equal to Rhizoma Cyperi, Pericarpium Citri Reticulatae and using.Folium Perillae is used for stagnation of QI in spleen and stomach, uncomfortable in chest, vomiting and nausea, no matter with or without table disease, all can apply, be all the effect of getting its promoting the circulation of QI to alleviate the stagnation in middle-JIAO, and clinical normal and Herba Pogostemonis compatibility is applied.In addition, this product has energy circulation of qi promoting antiabortive, often joins Fructus Amomi, the same use of Pericarpium Citri Reticulatae, treatment pregnancy reactions, frequent fetal movement.
Vitamin B6 (VitaminB6) is also known as pyridoxin.It is a kind of vitamin B group containing pyridoxol or 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine. or pyridoxamine.Vitamin B6 content in yeast, liver, grain, meat, fish, egg, beans and Semen arachidis hypogaeae is more.Vitamin B6 is the constituent of some coenzyme in human body, participates in multiple metabolic response, especially has substantial connection with amino acid metabolism.Along with going deep into of clinical application research, find that vitamin B6 also has novelty teabag widely clinically, vitamin B6 can be used for rescuing poisoning by isoniazid, treatment anemia, treatment leukopenia, treatment intelligent development sluggishness, treatment oral ulcer etc., also can apply Vitamin B6 preparation control vomiting during pregnancy and radiation sickness vomiting clinically.
Vitamin B12 is cobalamine again, and the vitamin B12 of occurring in nature is all Microbe synthesis, and high animals and plants can not manufacture vitamin B12.Vitamin B12 needs a kind of intestinal secretion thing (castle's intrinsic factor) to help the absorbed only a kind of vitamin of ability.The main Physiological Function of vitamin B12 has the following aspects: 1, promote erythrocytic growth and maturation, makes human body hematopoietic function be in normal condition, prevention pernicious anemia; Safeguard that nervous system is healthy.2, exist with the form of coenzyme, the utilization rate of folic acid can be increased, promote the metabolism of carbohydrate, fat and protein; 3, have the effect of activated amino acid and promote the biosynthesis of nucleic acid, can promote the synthesis of protein, it plays an important role to the growth promoter of infant.4, fat metabolism acid, makes fat, carbohydrate, protein suitably be used by health; 5, eliminate dysphoria, focus one's attention on, hypermnesis and equilibrium sense; 6, be that nervous function perfects indispensable vitamin, participate in the formation of a kind of lipoprotein in nervous tissue.
Pregnancy period toothpaste is specially pregnant female specific group and the mouth care article of everyday use that customizes.The health of this specific group of anemia of pregnant woman because be not only related to self, also with the health of fetus with grow closely bound up, so be subject to self, household and society are more concerned about and cherish.Along with the raising of socioeconomic development, living standards of the people, people have also gone up a class for the pursuit of quality of the life, the eating of anemia of pregnant woman, the demand for security of wearing, to use etc. each side obtain showing great attention to of society, and this oral care implement for special population of pregnancy period toothpaste special is also more and more accepted by anemia of pregnant woman and welcomes.
Summary of the invention
The object of this invention is to provide a kind of compound mormula folic acid toothpaste for the pregnancy period, its role is to alleviate the pregnancy period oral diseases such as pregnant gingivitis, gingival hemorrhage, anemia of pregnant woman's toothbrush also can be prevented simultaneously to cause nausea vomiting; The present invention there are provided the process for producing of this toothpaste simultaneously.
Compound mormula folic acid of the present invention is that be aided with the conventional raw material preparing toothpaste, toothpaste making process is routinely made by one or more in folic acid, Rhizoma Zingiberis Recens, Folium Perillae, vitamin B6, vitamin B12 for active component.With the toothpaste that above-mentioned active component is made, there is oral diseases such as alleviating pregnant gingivitis, gingival hemorrhage, prevent to brush teeth the effect of vomitting.
The folic acid used in this toothpaste, vitamin B6, vitamin B12 are the necessary oral nutritional supplements of pregnant women, can not produce any toxic and side effects to anemia of pregnant woman and fetus; The Chinese medicine that the Rhizoma Zingiberis Recens used in this toothpaste, Folium Perillae are commonly used for treatment vomiting during pregnancy, still can be used as the raw material eaten, safety is high, and the using dosage in this toothpaste can not produce any toxic and side effects to anemia of pregnant woman and fetus simultaneously.
In order to reach object of the present invention, in this toothpaste, the use amount scope of active component is (being mass fraction below): Rhizoma Zingiberis Recens volatile oil or extracting solution (0.01%-10%), Folium Perillae volatile oil or extracting solution (0.01%-10%), folic acid (0.005%-0.1%), vitamin B6 (0.01%-0.4%), vitamin B12 (0.001-0.01%).The mass fraction of this toothpaste dens in dente cream base furnish is 79.9%-99.9%.
Described Folium Perillae extracting solution be by Folium Perillae medical material through pulverizing, filtering and concentrating by chilling treatment, the relative density finally obtained is the extracting solution of 1.05-1.35 after water extraction or alcohol extraction;
The described Folium Perillae volatile oil relative density that to be Folium Perillae medical material obtain through steam distillation preparation within the scope of 0.83-0.92, the volatile oil of index of refraction within the scope of 1.452-1.588.
Described ginger extract be by Rhizoma Zingiberis Recens medical material through pulverizing, filtering and concentrating by chilling treatment, the relative density finally obtained is the extracting solution of 1.05-1.35 after water extraction or alcohol extraction;
The described Rhizoma Zingiberis Recens hair oil relative density that to be Folium Perillae medical material obtain through steam distillation preparation within the scope of 0.81-0.89, the volatile oil of index of refraction within the scope of 1.481-1.594.
Described folic acid, vitamin B6, vitamin B12 are the raw-food material of legal production.
Described toothpaste base furnish comprises: abrasivus 9%-60%, wetting agent 7%-35%, thickening agent 0.3%-5%, foaming agent 0.2%-2%, sweeting agent 0.1%-1%, spice 0%-1.5%, antiseptic 0%-0.55%, deionized water 0%-30%, appearance modifying agents 0.1%-5%.Wherein said abrasivus has silicon dioxide, hypophosphite monohydrate hydrogen calcium, calcium phosphate dibasic anhydrous, calcium carbonate, aluminium hydroxide, calcium pyrophosphate; Described wetting agent has Pyrusussuriensis (sugar) alcohol, glycerol, propylene glycol, PEG-8; Described thickening agent has sodium carboxymethyl cellulose, melon glue, sodium alginate, xanthan gum, guar hydroxypropyltrimonium ammonium chloride, carrageenin; Described foaming agent has sodium lauryl sulphate, sodium lauroyl sarcosine, sodium cocoyl glycinate, acyl glutamic acid sodium; Described sweeting agent has saccharin sodium, sucralose, xylitol, cyclamate, aspartame, stevioside, mogroside; Described spice has oleum Citri sinensis, orange essence oil, green apple, Fructus actinidiae chinensis, blue berry, Oleum menthae, Oleum Menthae Rotundifoliae, mandarin oil; Described antiseptic has benzoic acid and its esters, sorbic acid and its esters, parabens; Described appearance modifying agents has titanium dioxide, food coloring, food color lake, clean the teeth granule.
The pregnancy period toothpaste making process that the present invention relates to is as follows:
(1) folic acid, Rhizoma Zingiberis Recens and Folium perillae extract or volatile oil, vitamin B6, vitamin B12, foaming agent are added in glycerol or other suitable heat preserving agent, high-speed stirred is uniformly dispersed, and is prepared into solution or suspension;
(2) added in above-mentioned solution or suspension by thickening agent, dispersed with stirring is even.
(3) added by remaining heat preserving agent in the sample of step " (2) " gained, dispersed with stirring is even.Add appearance modifying agents again, dispersed with stirring is even.
(4) water intaking is appropriate, and add antiseptic, be uniformly dispersed, then add sweeting agent, dispersed with stirring is even.
(5) added by the sample of step " (4) " gained in the sample of step " (3) " gained, dispersed with stirring is even.Add abrasivus again, dispersed with stirring is even.Add spice again, dispersed with stirring is even.
(6) under vacuum condition is 0.08-0.12MPa, continues the obtained sample of dispersed with stirring homogenizing step " (5) " makes mastic, sterile filling forms.
Folic acid toothpaste of the present invention, its alleviate trimester of pregnancy and puerperal gingivitis, gingival hemorrhage, prevention trimester of pregnancy brush teeth cause nausea, confirmation that the effect of vomitting also obtains clinical research, result of study is as follows:
Use gingivitis, gingival hemorrhage evaluation result before and after folic acid toothpaste
Folic acid toothpaste is used to prevent to brush teeth vomiting evaluation result
Effective: vomiting number of times obviously reduces, and cardinal symptom has clear improvement.Take a turn for the better: symptoms of emesis alleviates.Invalid: to vomit all diseases all without improving or increasing the weight of.
When using toothpaste involved in the present invention, can according to individual mouth healthy condition, the proper extension toothpaste time of staying in the oral cavity, can better improve pregnancy period gingivitis, gingival hemorrhage, protect the health of one's mouth.
Detailed description of the invention
Example 1
Formula forms:
Folic acid 1g, ginger extract 50g, Folium Perillae extracting solution 50g, glycerol 150g, Pyrusussuriensis (sugar) alcohol 190g, silicon dioxide 290g, water 80g, xylitol 90g, sodium cocoyl glycinate 10g, edible essence (fragrant citrus) 5g, cellulose gum 10g, hydroxypropyl guar gum 4g, titanium dioxide 25g, methyl hydroxybenzoate 30g, propyl hydroxybenzoate 5g
Preparation technology:
1, get a certain amount of Rhizoma Zingiberis Recens medical material, pulverize, accurately take medical material 100g after pulverizing, add 1000mL water, decoct and extract 1h, overanxious, be concentrated into 500mL, in 4 DEG C of cold preservation 24h, microporous filter membrane 0.45 μm of filtration forms, and recording relative density is 1.075.Folium Perillae medical material same treatment, recording relative density is 1.081.
2, Rhizoma Zingiberis Recens and Folium perillae extract, folic acid, sodium cocoyl glycinate are added successively in glycerol, high-speed stirred 10min, is prepared into suspension;
2, cellulose gum, hydroxypropyl guar gum are added in above-mentioned suspension, stir 10min.
3, Pyrusussuriensis (sugar) alcohol liquid is added in the sample of step " (2) " gained, stir 15min.Add titanium dioxide again, stir 10min.
4, fetch water 80g, adds methyl hydroxybenzoate and propyl hydroxybenzoate, stirring and dissolving, then add xylitol, stirring and dissolving.
5, the sample of step " (4) " gained is added in the sample of step " (3) " gained, stir 20min.Add silicon dioxide again, stir 15min.Add edible essence again, stir 10min.
6, continue to stir 15min under vacuum condition is 0.08-0.12MPa, mastic made by the step that is uniformly dispersed " (5) " gained sample.
7, check, sterile filling enters in PAP, sealing, obtained toothpaste.
Example 2
Formula forms:
Folic acid 1g, ginger extract 25g, Folium Perillae extracting solution 25g, glycerol 150g, Pyrusussuriensis (sugar) alcohol 190g, silicon dioxide 290g, water 125g, xylitol 90g, sodium cocoyl glycinate 10g, edible essence (green apple) 5g, cellulose gum 10g, hydroxypropyl guar gum 4g, titanium dioxide 25g, methyl hydroxybenzoate 4g
Preparation technology:
1, get a certain amount of Rhizoma Zingiberis Recens medical material, pulverize, accurately take medical material 100g after pulverizing, add 1000mL water, decoct and extract 1h, overanxious, be concentrated into 500mL, in 4 DEG C of cold preservation 24h, microporous filter membrane 0.45 μm of filtration forms, and recording relative density is 1.075.Folium Perillae medical material same treatment, recording relative density is 1.081.
2, Rhizoma Zingiberis Recens and Folium perillae extract, folic acid, sodium cocoyl glycinate are added successively in glycerol, high-speed stirred 10min, is prepared into suspension;
2, cellulose gum, hydroxypropyl guar gum are added in above-mentioned suspension, stir 10min.
3, Pyrusussuriensis (sugar) alcohol liquid is added in the sample of step " (2) " gained, stir 15min.Add titanium dioxide again, stir 10min.
4, fetch water 125g, adds methyl hydroxybenzoate and propyl hydroxybenzoate, stirring and dissolving, then add xylitol, stirring and dissolving.
5, the sample of step " (4) " gained is added in the sample of step " (3) " gained, stir 20min.Add silicon dioxide again, stir 15min.Add edible essence again, stir 10min.
6, continue to stir 15min under vacuum condition is 0.08-0.12MPa, mastic made by the step that is uniformly dispersed " (5) " gained sample.
7, check, sterile filling enters in PAP, sealing, obtained toothpaste.
Example 3
Formula forms:
Folic acid 1g, Rhizoma Zingiberis Recens volatile oil 5g, Folium Perillae volatile oil 5g, glycerol 150g, Pyrusussuriensis (sugar) alcohol 190g, silicon dioxide 290g, water 135g, xylitol 120g, sodium lauryl sulphate 10g, cellulose gum 10g, hydroxypropyl guar gum 4g, titanium dioxide 25g, methyl hydroxybenzoate 40g, propyl hydroxybenzoate 5g
Preparation technology:
1, get a certain amount of Rhizoma Zingiberis Recens medical material, pulverize, accurately take medical material 100g after pulverizing, adopt steam distillation to extract continuously, obtain distillate after oil-water separation, obtain volatile oil, recording relative density is 0.86, index of refraction 1.501.Folium Perillae medical material same treatment, recording relative density is 0.88, index of refraction 1.524.
2, Rhizoma Zingiberis Recens and Folium Perillae volatile oil, folic acid, sodium lauryl sulphate are added successively in glycerol, high-speed stirred 10min, is prepared into suspension;
2, cellulose gum, hydroxypropyl guar gum are added in above-mentioned suspension, stir 10min.
3, Pyrusussuriensis (sugar) alcohol liquid is added in the sample of step " (2) " gained, stir 15min.Add titanium dioxide again, stir 10min.
4, fetch water 135g, adds methyl hydroxybenzoate and propyl hydroxybenzoate, stirring and dissolving, then add xylitol, stirring and dissolving.
5, the sample of step " (4) " gained is added in the sample of step " (3) " gained, stir 20min.Add silicon dioxide again, stir 15min.
6, continue to stir 15min under vacuum condition is 0.08-0.12MPa, mastic made by the step that is uniformly dispersed " (5) " gained sample.
7, check, sterile filling enters in PAP, sealing, obtained toothpaste.
Example 4
Formula forms:
Folic acid 1g, ginger extract 40g, Folium Perillae extracting solution 40g, vitamin B6 3g, vitamin B12 0.1g, glycerol 150g, Pyrusussuriensis (sugar) alcohol 190g, silicon dioxide 290g, water 96.9g, xylitol 90g, sodium cocoyl glycinate 10g, edible essence (green apple) 5g, cellulose gum 10g, hydroxypropyl guar gum 4g, titanium dioxide 25g, methyl hydroxybenzoate 30g, propyl hydroxybenzoate 5g
Preparation technology:
1, get a certain amount of Rhizoma Zingiberis Recens medical material, pulverize, accurately take medical material 100g after pulverizing, add 1000mL water, decoct and extract 1h, overanxious, be concentrated into 500mL, in 4 DEG C of cold preservation 24h, microporous filter membrane 0.45 μm of filtration forms, and recording relative density is 1.075.Folium Perillae medical material same treatment, recording relative density is 1.081.
2, Rhizoma Zingiberis Recens and Folium perillae extract, folic acid, vitamin B6, vitamin B12, sodium cocoyl glycinate are added successively in glycerol, high-speed stirred 10min, is prepared into suspension;
2, cellulose gum, hydroxypropyl guar gum are added in above-mentioned suspension, stir 10min.
3, Pyrusussuriensis (sugar) alcohol liquid is added in the sample of step " (2) " gained, stir 15min.Add titanium dioxide again, stir 10min.
4, fetch water 96.9g, adds methyl hydroxybenzoate and propyl hydroxybenzoate, stirring and dissolving, then add xylitol, stirring and dissolving.
5, the sample of step " (4) " gained is added in the sample of step " (3) " gained, stir 20min.Add silicon dioxide again, stir 15min.Add edible essence again, stir 10min.
6, continue to stir 15min under vacuum condition is 0.08-0.12MPa, mastic made by the step that is uniformly dispersed " (5) " gained sample.
7, check, sterile filling enters in PAP, sealing, obtained toothpaste.
Example 5
Formula forms:
Folic acid 1g, Rhizoma Zingiberis Recens volatile oil 5g, Folium Perillae volatile oil 5g, vitamin B6 2g, vitamin B12 0.1g, glycerol 150g, Pyrusussuriensis (sugar) alcohol 190g, silicon dioxide 290g, water 132.9g, xylitol 120g, sodium lauryl sulphate 10g, cellulose gum 10g, hydroxypropyl guar gum 4g, titanium dioxide 25g, methyl hydroxybenzoate 40g, propyl hydroxybenzoate 5g
Preparation technology:
1, get a certain amount of Rhizoma Zingiberis Recens medical material, pulverize, accurately take medical material 100g after pulverizing, adopt steam distillation to extract continuously, obtain distillate after oil-water separation, obtain volatile oil, recording relative density is 0.86, index of refraction 1.501.Folium Perillae medical material same treatment, recording relative density is 0.88, index of refraction 1.524.
2, Rhizoma Zingiberis Recens and Folium Perillae volatile oil, folic acid, vitamin B6, vitamin B12, sodium lauryl sulphate are added successively in glycerol, high-speed stirred 10min, is prepared into suspension;
2, cellulose gum, hydroxypropyl guar gum are added in above-mentioned suspension, stir 10min.
3, Pyrusussuriensis (sugar) alcohol liquid is added in the sample of step " (2) " gained, stir 15min.Add titanium dioxide again, stir 10min.
4, fetch water 132.9g, adds methyl hydroxybenzoate and propyl hydroxybenzoate, stirring and dissolving, then add xylitol, stirring and dissolving.
5, the sample of step " (4) " gained is added in the sample of step " (3) " gained, stir 20min.Add silicon dioxide again, stir 15min.
6, continue to stir 15min under vacuum condition is 0.08-0.12MPa, mastic made by the step that is uniformly dispersed " (5) " gained sample.
7, check, sterile filling enters in PAP, sealing, obtained toothpaste.
Example 6
Formula forms:
Folic acid 0.5g, ginger extract 50g, Folium Perillae extracting solution 50g, glycerol 150g, Pyrusussuriensis (sugar) alcohol 190g, silicon dioxide 290g, water 80.5g, xylitol 90g, sodium cocoyl glycinate 10g, edible essence (fragrant citrus) 5g, cellulose gum 10g, hydroxypropyl guar gum 4g, titanium dioxide 25g, sodium benzoate 35g
Preparation technology:
1, get a certain amount of Rhizoma Zingiberis Recens medical material, pulverize, accurately take medical material 100g after pulverizing, add 1000mL water, decoct and extract 1h, overanxious, be concentrated into 500mL, in 4 DEG C of cold preservation 24h, microporous filter membrane 0.45 μm of filtration forms, and recording relative density is 1.075.Folium Perillae medical material same treatment, recording relative density is 1.081.
2, Rhizoma Zingiberis Recens and Folium perillae extract, folic acid, sodium cocoyl glycinate are added successively in glycerol, high-speed stirred 10min, is prepared into suspension;
2, cellulose gum, hydroxypropyl guar gum are added in above-mentioned suspension, stir 10min.
3, Pyrusussuriensis (sugar) alcohol liquid is added in the sample of step " (2) " gained, stir 15min.Add titanium dioxide again, stir 10min.
4, fetch water 80.5g, adds sodium benzoate, stirring and dissolving, then add xylitol, stirring and dissolving.
5, the sample of step " (4) " gained is added in the sample of step " (3) " gained, stir 20min.Add silicon dioxide again, stir 15min.Add edible essence again, stir 10min.
6, continue to stir 15min under vacuum condition is 0.08-0.12MPa, mastic made by the step that is uniformly dispersed " (5) " gained sample.
7, check, sterile filling enters in PAP, sealing, obtained toothpaste.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvement and modification, these improve and modification also should be considered as protection scope of the present invention.
Claims (9)
1. a folic acid toothpaste, comprises folic acid that mass fraction is 0.005%-0.1%, Folium Perillae volatile oil that Rhizoma Zingiberis Recens volatile oil that mass fraction is 0.01%-10% or extracting solution and mass fraction are 0.01%-10% or extracting solution and mass fraction is 79.9%-99.9% toothpaste base furnish.
2. folic acid toothpaste according to claim 1, is characterized in that: it is the vitamin B6 of 0.01%-0.4% that described toothpaste also contains mass fraction.
3. folic acid toothpaste according to claim 1, is characterized in that: it is the vitamin B12 of 0.001-0.01% that described toothpaste also contains mass fraction.
4. folic acid toothpaste according to claim 1, is characterized in that: described toothpaste base furnish comprises following component by percentage to the quality: abrasivus 9%-60%, wetting agent 7%-35%, thickening agent 0.3%-5%, foaming agent 0.2%-2%, sweeting agent 0.1%-1%, spice 0%-1.5%, antiseptic 0%-0.55%, deionized water 0%-30%, appearance modifying agents 0.1%-5%.
5. folic acid toothpaste according to claim 1, is characterized in that: described ginger extract be by Rhizoma Zingiberis Recens medical material through pulverizing, concentrated and by chilling treatment, the relative density finally obtained is the extracting solution of 1.05-1.35 after water extraction or alcohol extraction; The described Rhizoma Zingiberis Recens volatile oil relative density that to be Rhizoma Zingiberis Recens medical material obtain through steam distillation preparation within the scope of 0.81-0.89, the volatile oil of index of refraction within the scope of 1.481-1.594.
6. folic acid toothpaste according to claim 1, is characterized in that: described Folium Perillae extracting solution be by Folium Perillae medical material through pulverizing, concentrated and by chilling treatment, the relative density finally obtained is the extracting solution of 1.05-1.35 after water extraction or alcohol extraction; The described Folium Perillae volatile oil relative density that to be Folium Perillae medical material obtain through steam distillation preparation within the scope of 0.83-0.92, the volatile oil of index of refraction within the scope of 1.452-1.588.
7. folic acid toothpaste according to claim 4, is characterized in that: described abrasivus has silicon dioxide, hypophosphite monohydrate hydrogen calcium, calcium phosphate dibasic anhydrous, calcium carbonate, aluminium hydroxide, calcium pyrophosphate; Described wetting agent has Pyrusussuriensis (sugar) alcohol, glycerol, propylene glycol, PEG-8; Described thickening agent has sodium carboxymethyl cellulose, melon glue, sodium alginate, xanthan gum, guar hydroxypropyltrimonium ammonium chloride, carrageenin; Described foaming agent has sodium lauryl sulphate, sodium lauroyl sarcosine, sodium cocoyl glycinate, acyl glutamic acid sodium; Described sweeting agent has saccharin sodium, sucralose, xylitol, cyclamate, aspartame, stevioside, mogroside; Described spice has oleum Citri sinensis, orange essence oil, green apple, Fructus actinidiae chinensis, blue berry, Oleum menthae, Oleum Menthae Rotundifoliae, mandarin oil; Described antiseptic has benzoic acid and its esters, sorbic acid and its esters, parabens; Described appearance modifying agents comprises titanium dioxide, food coloring, food color lake, clean the teeth granule.
8. a preparation method for the folic acid toothpaste described in claim 1-7, its processing step is as follows:
(1) said extracted thing or volatile oil, folic acid, vitamin B6, vitamin B12, foaming agent are added in glycerol or other suitable heat preserving agent, high-speed stirred is uniformly dispersed, and is prepared into solution or suspension;
(2) added in above-mentioned solution or suspension by thickening agent, dispersed with stirring is even.
(3) added by remaining heat preserving agent in the sample of step " (2) " gained, dispersed with stirring is even.Add appearance modifying agents again, dispersed with stirring is even.
(4) water intaking is appropriate, and add antiseptic, be uniformly dispersed, then add sweeting agent, dispersed with stirring is even.
(5) added by the sample of step " (4) " gained in the sample of step " (3) " gained, dispersed with stirring is even.Add abrasivus again, dispersed with stirring is even.Add spice again, dispersed with stirring is even.
(6) at vacuum condition for mastic made by the sample continued under 0.08-0.12MPa obtained by dispersed with stirring homogenizing step " (5) ", sterile filling forms.
9. the method according to right 8, it is levied and is: step (1) described in, the vitamin B6 that the Rhizoma Zingiberis Recens volatile oil of the composition added in glycerol to be mass fraction be 0.01%-10% or extracting solution, mass fraction are the Folium Perillae volatile oil of 0.01%-10% or extracting solution, mass fraction is the folic acid of 0.005%-0.1%, mass fraction is 0.01%-0.4% and mass fraction be one or more in the vitamin B12 of 0.001-0.01%.
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| CN105663015A (en) * | 2016-03-24 | 2016-06-15 | 广州健朗医用科技有限公司 | Special propolis toothpaste for pregnant and lying-in women and preparation method of special propolis toothpaste |
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| CN106109357B (en) * | 2016-08-25 | 2019-04-12 | 青岛魁宇本草生物科技有限公司 | A kind of toothpaste and preparation method thereof |
| CN107929428A (en) * | 2017-12-20 | 2018-04-20 | 弘美制药（中国）有限公司 | A kind of composition and its application for oral cavity |
| CN107929428B (en) * | 2017-12-20 | 2021-01-26 | 弘美制药（中国）有限公司 | Composition for oral cavity and application thereof |
| EP3890739A4 (en) * | 2018-12-08 | 2022-10-26 | Aphios Corporation | Methods and products for treating folic acid deficiency and morning sickness |
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