CN106109357A - A kind of toothpaste and preparation method thereof - Google Patents
A kind of toothpaste and preparation method thereof Download PDFInfo
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- CN106109357A CN106109357A CN201610726177.9A CN201610726177A CN106109357A CN 106109357 A CN106109357 A CN 106109357A CN 201610726177 A CN201610726177 A CN 201610726177A CN 106109357 A CN106109357 A CN 106109357A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The present invention relates to field of toothpaste, particularly to a kind of toothpaste and preparation method thereof.A kind of toothpaste, is mainly made up of Ilex purpurea Hassk.[I.chinensis Sims, Folium perillae extract, Folium Mori extract and adjuvant；Wherein, it is 0.1% 1% that Ilex purpurea Hassk.[I.chinensis Sims accounts for the percetage by weight of toothpaste, and it is 0.1% 1% that Folium perillae extract accounts for the percetage by weight of toothpaste, and it is 0.1% 1% that Folium Mori extract accounts for the percetage by weight of toothpaste.The toothpaste that the present invention provides, Ilex purpurea Hassk.[I.chinensis Sims, Folium perillae extract and Folium Mori extract is added first in toothpaste, these three Chinese medicine extract is with specific ratio mating reaction, having collaborative reinforced effects, prepared toothpaste has the multi-efficiencies such as anti-inflammation hemostasia, fresh breath and suppression oral ulcer.The preparation method of the toothpaste that the present invention also provides for, this preparation method is simple and easy to do, and each component distributing of toothpaste prepared is homogeneous, function admirable.
Description
Technical field
The present invention relates to field of toothpaste, in particular to a kind of toothpaste and preparation method thereof.
Background technology
Toothpaste is the articles for daily use that people are indispensable, for oral cavity cleaning or prevention oral disease, due to present people's
Dietary life habits, oral problem becomes increasingly prevalent, and the toothpaste being provided purely for oral cavity cleaning is the most gradually difficult to meet people
Demand, therefore there is suppression gingival hemorrhage, the toothpaste of the detumescence special efficacy such as antiallergic has become as newly becoming of toothpaste development
Gesture.
In view of this, the special proposition present invention.
Summary of the invention
The first object of the present invention is to provide a kind of toothpaste, and this toothpaste with the addition of Ilex purpurea Hassk.[I.chinensis Sims, Folium Perillae extracts
Thing and Folium Mori extract, the effect of cooperating between each extract, make toothpaste have anti-inflammation hemostasia, fresh breath and suppression
The multi-efficiencies such as oral ulcer.
The second object of the present invention is to provide the preparation method of a kind of described toothpaste, and this preparation method is simple and easy to do,
The each component distributing of toothpaste prepared is homogeneous, function admirable.
In order to realize the above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of toothpaste, is mainly made up of Ilex purpurea Hassk.[I.chinensis Sims, Folium perillae extract, Folium Mori extract and adjuvant；
Wherein, it is 0.1%-1% that described Ilex purpurea Hassk.[I.chinensis Sims accounts for the percetage by weight of described toothpaste, and described Folium Perillae extracts
It is 0.1%-1% that thing accounts for the percetage by weight of described toothpaste, and described Folium Mori extract accounts for the percetage by weight of described toothpaste and is
0.1%-1%.
The toothpaste that the present invention provides, with the addition of Ilex purpurea Hassk.[I.chinensis Sims, Folium perillae extract and Folium Mori extract, wherein, four
Season green grass or young crops extract, Folium perillae extract and Folium Mori extract be commercially available prod.The present invention by these three Chinese medicine extract with spy
Fixed ratio mating reaction, has collaborative reinforced effects, and prepared toothpaste has anti-inflammation hemostasia, fresh breath and suppression oral cavity
The multi-efficiencies such as ulcer.
Ilex purpurea Hassk.[I.chinensis Sims mainly contains the active substance such as phenolic acids, triterpene and triterpene saponin, flavonoid, volatile oil, has
Broad spectrum antibacterial, has antiinflammatory and goes to swell, suppress the effect of oral ulcer, and Ilex purpurea Hassk.[I.chinensis Sims also has anastalsis, can
To suppress gingival hemorrhage.Recording according to Chinese medicine ancient books such as Sheng Nong's herbal classic, Folium Mori have the effect of anti-inflammation detumescence, and modern science is ground
Studying carefully and also demonstrate that, the flavone compound in Folium Mori can effectively suppress antibacterial, and research simultaneously is it has also been found that the polysaccharide that contains in Folium Mori
Can effectively reduce blood glucose with alkaloid, the toothpaste during therefore diabetes patient uses the present invention also can play the work of auxiliary hyperglycemic
With.Containing a large amount of volatile oil components in Folium Perillae, volatile oil itself has the effect of causing resuscitation with aromatic drugs, can be the most clear in toothpaste
Removing abnormal flavor in oral cavity, keeps breath freshening.And studying and show, Folium Perillae volatile oil has obvious inhibiting bacteria and diminishing inflammation effect, can have
Effect suppression gingival swelling and pain.
In order to reach more superior effect, it is preferable that described Ilex purpurea Hassk.[I.chinensis Sims accounts for the percetage by weight of described toothpaste and is
0.3%-0.8%, it is 0.15%-0.5% that described Folium perillae extract accounts for the percetage by weight of described toothpaste, and described Folium Mori extract
It is 0.15%-0.5% that thing accounts for the percetage by weight of described toothpaste.
It is highly preferred that it is 0.4%-0.6% that described Ilex purpurea Hassk.[I.chinensis Sims accounts for the percetage by weight of described toothpaste, described Folium Perillae
It is 0.2%-0.3% that leaf extract accounts for the percetage by weight of described toothpaste, and described Folium Mori extract accounts for the weight hundred of described toothpaste
Mark is 0.2%-0.3%.
The toothpaste that the present invention provides, is to the addition of Ilex purpurea Hassk.[I.chinensis Sims, Folium perillae extract on the basis of ordinary toothpaste
And Folium Mori extract, prepared toothpaste has the multi-efficiencies such as anti-inflammation hemostasia, fresh breath and suppression oral ulcer.
Further, described adjuvant at least includes abrasivus, thickening agent, excipient, wetting agent, foaming agent, adhesive, sweet
Taste agent, preservative and deionized water；Alternatively, essence and corrosion inhibiter are also included.
Specifically, any one during described abrasivus is silicon dioxide, calcium bicarbonate, calcium carbonate and calcium phosphate dibasic dihydrate
Or it is multiple；
Described thickening agent is silicon dioxide；
Described excipient is Sorbitol；
Described wetting agent is glycerol or Polyethylene Glycol；
Described essence is Mint Essence or Herba Menthae Rotundifoliae essence；
Described foaming agent is sodium laurylsulfate；
Described adhesive be any one in hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan and cellulose gum or
Multiple；
Described sweeting agent is saccharin sodium；
Described corrosion inhibiter is sodium pyrophosphate；
Described preservative is sodium benzoate.
Empirical tests, uses these adjuvants above-mentioned, prepared toothpaste function admirable, and carries with Ilex purpurea Hassk.[I.chinensis Sims, Folium Perillae
Take thing and Folium Mori extract coordinated, reach the effects such as more preferable anti-inflammation hemostasia, fresh breath and suppression oral ulcer.
Through assay optimization, if not containing corrosion inhibiter, it is preferable that percentage, in described toothpaste, described friction
The content of agent is 10%-50%, and the content of described thickening agent is 5%-20%, and the content of described excipient is 20%-50%, institute
The content stating wetting agent is 2%-10%, and the content of described essence is 0%-2%, and the content of described foaming agent is 1%-5%, institute
The content stating adhesive is 1%-5%, and the content of described sweeting agent is 0.1%-1%, and the content of described preservative is 0.1%-
0.5%, surplus is deionized water.
If containing corrosion inhibiter, it is preferable that percentage, in described toothpaste, the content of described abrasivus is
10%-50%, the content of described thickening agent is 5%-30%, and the content of described excipient is 20%-50%, described wetting agent
Content is 2%-10%, and the content of described essence is 0%-2%, and the content of described foaming agent is 1%-5%, described adhesive
Content is 1%-5%, and the content of described sweeting agent is 0.1%-1%, and the content of described corrosion inhibiter is 0.1%-0.5%, described
The content of preservative is 0.1%-0.5%, and surplus is deionized water.
Further, percentage, in described toothpaste, the content of described abrasivus is 15%-40%, described
The content of thickening agent is 10%-30%, and the content of described excipient is 30%-40%, and the content of described wetting agent is 5%-
8%, the content of described essence is 0.5%-1.5%, and the content of described foaming agent is 2%-4%, and the content of described adhesive is
2%-3%, the content of described sweeting agent is 0.3%-0.7%, and the content of described corrosion inhibiter is 0.2%-0.3%, described anticorrosion
The content of agent is 0.2%-0.3%, and surplus is deionized water.
Wherein, the essence in adjuvant can cover the bitterness of Chinese medicine own after adding, and as without essence, has after brushing teeth in oral cavity
Pained taste of Chinese medicine residual, for avoiding user uncomfortable Chinese medicine taste, so adding appropriate amount of essence, can make toothpaste keep one
Fixed Chinese medicine bitterness, excess interpolation does not causes essence taste the denseest again.
Present invention also offers the preparation method of above-mentioned toothpaste, comprise the following steps:
A (), preparation are extracted containing Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori containing adhesive and the first mixed liquor of excipient, preparation
Second mixed liquor of thing, Folium perillae extract, sweeting agent, corrosion inhibiter, preservative and wetting agent；
(b), by described first mixed liquor and described second mixed liquor mixing, obtain colloidal thing；
C (), addition abrasivus and thickening agent, addition foaming agent after mixing, mixing in described colloidal thing, add perfume
Essence, mixing, obtain described toothpaste after homogenizing；
If adjuvant does not include essence and corrosion inhibiter, then corresponding step is omitted.
The preparation method of the toothpaste that the present invention provides, each composition is by progressively adding so that each materials compatibility is good, respectively becomes
Distribution is homogeneous, the toothpaste function admirable prepared.
In order to reach preferably to mix and compatibility effect, further, in step (c), mixing is all at vacuum water-bath
In carry out.
In order to obtain more preferable homogenizing effect, prepared toothpaste more excellent performance, further, in step (c), described
The time of homogenizing is 1.5-2.0 hour.
Compared with prior art, the invention have the benefit that
(1) toothpaste that the present invention provides, adds Ilex purpurea Hassk.[I.chinensis Sims, Folium perillae extract and Folium Mori first in toothpaste and carries
Taking thing, these three Chinese medicine extract, with specific ratio mating reaction, has collaborative reinforced effects, and prepared toothpaste has antiinflammatory
The multi-efficiencies such as hemostasis, fresh breath and suppression oral ulcer.
(2) present invention also defines the interpolation content of Ilex purpurea Hassk.[I.chinensis Sims, Folium perillae extract and Folium Mori extract, to increase
Collaborative reinforced effects between strong each raw material.
(3) present invention also defines kind and the consumption of adjuvant, to obtain the toothpaste of function admirable.
(4) preparation method of the toothpaste that the present invention also provides for, this preparation method is simple and easy to do, and each composition of toothpaste prepared divides
Cloth is homogeneous, function admirable.
Detailed description of the invention
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but those skilled in the art will
Understanding, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.In embodiment unreceipted specifically
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or instrument unreceipted production firm person, be
Can be by the commercially available conventional products bought and obtain.
Embodiment 1
A kind of toothpaste, uses following methods to prepare:
Take following raw material: sorbitol solution 60g (mass concentration is 70%), silica 1 8g, glycerol 4g, Laurel
Alcohol sodium sulfate 2g, Herba Menthae Rotundifoliae essence 1.4g, Ilex purpurea Hassk.[I.chinensis Sims 0.5g, Folium perillae extract 0.25g, Folium Mori extract 0.25g, fine
Dimension element glue 0.3g, carrageenan 0.2g, saccharin sodium 0.2g, sodium benzoate 0.2g, sodium pyrophosphate 0.2g, deionized water 12.5g；
Carrageenan and cellulose gum add in sorbitol solution, are uniformly mixed so as to obtain the first mixed liquor；
Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract, Folium perillae extract, saccharin sodium, sodium benzoate, sodium pyrophosphate and glycerol with
Deionized water mixes, and obtains the second mixed liquor；
Second mixed solution and the mixing of the first mixed liquor, obtain colloid；
Adding silicon dioxide after colloid is uniform, vacuum water-bath stirs 1 hour, adds sodium laurylsulfate lauryl alcohol sulphuric acid
Sodium, vacuum water-bath stirs 30 minutes, adds Herba Menthae Rotundifoliae essence, continues vacuum water-bath and stirs 15 minutes；
Stop vacuum stirring, homogenizing 2 hours after having stirred, obtain toothpaste.
Embodiment 2
A kind of toothpaste, uses following methods to prepare:
Take following raw material: calcium bicarbonate 10g, sorbitol solution 70g (mass concentration is 70%), silicon dioxide 5g,
PEG-4000 2g, sodium laurylsulfate 5g, Herba Menthae Rotundifoliae essence 1g, Ilex purpurea Hassk.[I.chinensis Sims 1g, Folium perillae extract 0.1g, Mulberry
Leaf extract 0.1g, hydroxyethyl cellulose 1g, saccharin sodium 1g, sodium benzoate 0.1g, sodium pyrophosphate 0.1g, deionized water 3.6g；
Hydroxyethyl cellulose adds in sorbitol solution, is uniformly mixed so as to obtain the first mixed liquor；
Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract, Folium perillae extract, saccharin sodium, sodium benzoate, sodium pyrophosphate and poly-second two
Alcohol-400 mixes with deionized water, obtains the second mixed liquor；
Second mixed solution and the mixing of the first mixed liquor, obtain colloid；
Adding calcium bicarbonate and silicon dioxide after colloid is uniform, vacuum water-bath stirs 1 hour, adds lauryl alcohol sulphuric acid
Sodium, vacuum water-bath stirs 30 minutes, adds Herba Menthae Rotundifoliae essence, continues vacuum water-bath and stirs 15 minutes；
Stop vacuum stirring, homogenizing 1.5 hours after having stirred, obtain toothpaste.
Embodiment 3
A kind of toothpaste, uses following methods to prepare:
Take following raw material: calcium bicarbonate 10g, calcium phosphate dibasic dihydrate 10g, (mass concentration is sorbitol solution 30g
70%), silicon dioxide 5g, glycerol 10g, sodium laurylsulfate 3g, Mint Essence 2g, Ilex purpurea Hassk.[I.chinensis Sims 0.3g, Folium Perillae carries
Take thing 0.5g, Folium Mori extract 0.5g, cellulose gum 5g, saccharin sodium 0.5g, sodium benzoate 0.3g, sodium pyrophosphate 0.5g, go from
Sub-water 7.4g；
Cellulose gum adds in sorbitol solution, is uniformly mixed so as to obtain the first mixed liquor；
Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract, Folium perillae extract, saccharin sodium, sodium benzoate, sodium pyrophosphate and glycerol with
Deionized water mixes, and obtains the second mixed liquor；
Second mixed solution and the mixing of the first mixed liquor, obtain colloid；
Adding calcium bicarbonate, calcium phosphate dibasic dihydrate and silicon dioxide after colloid is uniform, vacuum water-bath stirs 1 hour,
Adding sodium laurylsulfate, vacuum water-bath stirs 30 minutes, adds Mint Essence, continues vacuum water-bath and stirs 15 minutes；
Stop vacuum stirring, homogenizing 2.5 hours after having stirred, obtain toothpaste.
Embodiment 4
A kind of toothpaste, uses following methods to prepare:
Take following raw material: calcium phosphate dibasic dihydrate 37g, silicon dioxide 8g, (mass concentration is sorbitol solution 30g
70%), glycerol 5g, sodium carboxymethyl cellulose 2g, sodium lauryl sulphate 2g, Herba Menthae Rotundifoliae essence 1g, saccharin sodium 0.1g, sodium benzoate
1g, Ilex purpurea Hassk.[I.chinensis Sims 0.1g, Folium perillae extract 1g, Folium Mori extract 1g, deionized water 11.8g；
Sodium carboxymethyl cellulose adds in sorbitol solution, is uniformly mixed so as to obtain the first mixed liquor；
Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract, Folium perillae extract, saccharin sodium, sodium benzoate mix with deionized water,
To the second mixed liquor；
Second mixed solution and the mixing of the first mixed liquor, obtain colloid；
Adding calcium phosphate dibasic dihydrate and silicon dioxide after colloid is uniform, vacuum water-bath stirs 1 hour, adds lauryl alcohol
Sodium sulfate, vacuum water-bath stirs 30 minutes, adds Herba Menthae Rotundifoliae essence, continues vacuum water-bath and stirs 15 minutes；
Stop vacuum stirring, homogenizing 2 hours after having stirred, obtain toothpaste.
Embodiment 5
A kind of toothpaste, uses following methods to prepare:
Take following raw material: calcium phosphate dibasic dihydrate 50g, silicon dioxide 5g, (mass concentration is sorbitol solution 21g
70%), Polyethylene Glycol 3g, hydroxyethyl cellulose 3g, sodium lauryl sulphate 2g, saccharin sodium 0.1g, sodium benzoate 0.5g, the four seasons
Blue or green extract 0.5g, Folium perillae extract 0.2g, Folium Mori extract 0.3g, deionized water 5.4g；
Hydroxyethyl cellulose adds in sorbitol solution, is uniformly mixed so as to obtain the first mixed liquor；
Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract, Folium perillae extract, saccharin sodium, sodium benzoate, Polyethylene Glycol and deionization
Water mixes, and obtains the second mixed liquor；
Second mixed solution and the mixing of the first mixed liquor, obtain colloid；
Adding calcium phosphate dibasic dihydrate and silicon dioxide after colloid is uniform, vacuum water-bath stirs 1 hour, adds lauryl alcohol
Sodium sulfate, vacuum water-bath stirs 30 minutes；
Stop vacuum stirring, homogenizing 2 hours after having stirred, obtain toothpaste.
Embodiment 6
A kind of toothpaste, uses following methods to prepare:
Take following raw material: calcium bicarbonate 15g, silicon dioxide 30g, sorbitol solution 28g (mass concentration is 70%),
Glycerol 2g, hydroxyethyl cellulose 1g, carrageenan 1g, sodium lauryl sulphate 5g, Herba Menthae Rotundifoliae essence 1g, saccharin sodium 0.3g, benzoic acid
Sodium 0.3g, Ilex purpurea Hassk.[I.chinensis Sims 0.8g, Folium perillae extract 0.15g, Folium Mori extract 0.15g, deionized water 3.3g；
Hydroxyethyl cellulose and carrageenan add in sorbitol solution, are uniformly mixed so as to obtain the first mixed liquor；
Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract, Folium perillae extract, saccharin sodium, sodium benzoate, glycerol mix with deionized water
Close, obtain the second mixed liquor；
Second mixed solution and the mixing of the first mixed liquor, obtain colloid；
Adding calcium bicarbonate and silicon dioxide after colloid is uniform, vacuum water-bath stirs 1 hour, adds lauryl alcohol sulphuric acid
Sodium, vacuum water-bath stirs 30 minutes, adds Herba Menthae Rotundifoliae essence, continues vacuum water-bath and stirs 15 minutes；
Stop vacuum stirring, homogenizing 2 hours after having stirred, obtain toothpaste.
Embodiment 7
A kind of toothpaste, uses following methods to prepare:
Take following raw material: calcium bicarbonate 10g, calcium carbonate 10g, calcium phosphate dibasic dihydrate 10g, silica 1 5g, Pyrusussuriensis
Sugar alcohol solution 40g (mass concentration is 70%), Polyethylene Glycol 2g, hydroxyethyl cellulose 1g, sodium carboxymethyl cellulose 2g, carrageenan
1g, cellulose gum 1g, sodium lauryl sulphate 1g, saccharin sodium 0.8g, sodium benzoate 0.2g, Ilex purpurea Hassk.[I.chinensis Sims 0.6g, Folium Perillae
Leaf extract 0.3g, Folium Mori extract 0.3g, deionized water 4.8g；
Hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan and cellulose gum add in sorbitol solution, mix
To the first mixed liquor；
Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract, Folium perillae extract, saccharin sodium, sodium benzoate, Polyethylene Glycol and deionization
Water mixes, and obtains the second mixed liquor；
Second mixed solution and the mixing of the first mixed liquor, obtain colloid；
Adding calcium bicarbonate, calcium carbonate, calcium phosphate dibasic dihydrate and silicon dioxide after colloid is uniform, vacuum water-bath stirs
1 hour, adding sodium laurylsulfate, vacuum water-bath stirs 30 minutes；
Stop vacuum stirring, homogenizing 2.5 hours after having stirred, obtain toothpaste.
Embodiment 8
A kind of toothpaste, uses following methods to prepare:
Take following raw material: calcium carbonate 10g, calcium phosphate dibasic dihydrate 10g, silica 1 0g, sorbitol solution 50g
(mass concentration is 70%), glycerol 4g, cellulose gum 2g, sodium lauryl sulphate 3g, Mint Essence 1.5g, saccharin sodium 1g, benzene
Sodium formate 0.3g, Ilex purpurea Hassk.[I.chinensis Sims 0.4g, Folium perillae extract 0.2g, Folium Mori extract 0.2g, deionized water 7.4g；
Cellulose gum adds in sorbitol solution, is uniformly mixed so as to obtain the first mixed liquor；
Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract, Folium perillae extract, saccharin sodium, sodium benzoate, glycerol mix with deionized water
Close, obtain the second mixed liquor；
Second mixed solution and the mixing of the first mixed liquor, obtain colloid；
Adding calcium carbonate, calcium phosphate dibasic dihydrate and silicon dioxide after colloid is uniform, vacuum water-bath stirs 1 hour, adds
Entering sodium laurylsulfate, vacuum water-bath stirs 30 minutes, adds Mint Essence, continues vacuum water-bath and stirs 15 minutes；
Stop vacuum stirring, homogenizing 1.5 hours after having stirred, obtain toothpaste.
Matched group 1
Removing Ilex purpurea Hassk.[I.chinensis Sims, Folium perillae extract and Folium Mori extract, remaining is with embodiment 1, the toothpaste made.
Matched group 2
Remove the Folium perillae extract in embodiment 1 and Folium Mori extract, and change the consumption of Ilex purpurea Hassk.[I.chinensis Sims into 1g,
Remaining is with embodiment 1, the toothpaste made.
Matched group 3
Remove the Ilex purpurea Hassk.[I.chinensis Sims in embodiment 1, and the consumption of Folium perillae extract and Folium Mori extract is all changed into
0.5g, remaining is with embodiment 1, the toothpaste made.
Experimental example 1
According to the method for embodiment 1-8 and matched group 1-3 prepare abundant toothpaste carry out oral ulcer, halitosis and
The compliance test result of gingival hemorrhage symptom.
1, for oral ulcer
Specifically, the volunteer randomly selecting 550 oral ulcer is divided into 11 groups at random, carries out using and verifies, three days
The number of rear statistics different-effect, effect is divided into and is clearly better, takes a turn for the better and invalid, transfers the best canker sores sense to and alleviates, has
Improvement trend, and inhibited, do not continue to increase the weight of.Concrete as shown in table 1.
Oral ulcer effect treated by table 1
| Group | It is clearly better | Take a turn for the better | Invalid |
| Embodiment 1 | 30 | 20 | 0 |
| Embodiment 2 | 17 | 25 | 8 |
| Embodiment 3 | 20 | 26 | 4 |
| Embodiment 4 | 15 | 20 | 15 |
| Embodiment 5 | 29 | 21 | 0 |
| Embodiment 6 | 25 | 20 | 5 |
| Embodiment 7 | 28 | 21 | 1 |
| Embodiment 8 | 27 | 22 | 1 |
| Matched group 1 | 0 | 0 | 50 |
| Matched group 2 | 15 | 13 | 22 |
| Matched group 3 | 12 | 12 | 26 |
As it can be seen from table 1 have the effect of collaborative enhancing, boil on the nape opposite the mouth between each raw material of toothpaste for preparing of the embodiment of the present invention
The effect of chamber ulcer is substantially better than and is used alone or both carry with the use of Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract and Folium Perillae
Take thing, and, in toothpaste, Ilex purpurea Hassk.[I.chinensis Sims content is 0.4%-0.6%, and Folium perillae extract content is 0.2%-0.3%,
Folium Mori extract content is that 0.2%-0.3% effect is more excellent.
2, for halitosis
Specifically, the volunteer randomly selecting 550 halitosis is divided into 11 groups at random, carries out using checking, a Zhou Houtong
Meter different-effect number, effect be divided into be clearly better, make moderate progress and change inconspicuous.Concrete as shown in table 2.
Halitosis effect treated by table 2
| Group | It is clearly better | Take a turn for the better | Invalid |
| Embodiment 1 | 27 | 10 | 13 |
| Embodiment 2 | 15 | 10 | 25 |
| Embodiment 3 | 25 | 9 | 14 |
| Embodiment 4 | 18 | 17 | 15 |
| Embodiment 5 | 20 | 15 | 15 |
| Embodiment 6 | 17 | 16 | 17 |
| Embodiment 7 | 26 | 12 | 12 |
| Embodiment 8 | 23 | 13 | 14 |
| Matched group 1 | 0 | 0 | 50 |
| Matched group 2 | 0 | 15 | 35 |
| Matched group 3 | 12 | 10 | 28 |
From table 2 it can be seen that have the effect of collaborative enhancing, boil on the nape opposite the mouth between each raw material of toothpaste for preparing of the embodiment of the present invention
Smelly effect be substantially better than be used alone or both with the use of Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract and Folium Perillae extract
Thing, and, in toothpaste, Ilex purpurea Hassk.[I.chinensis Sims content is 0.4%-0.6%, and Folium perillae extract content is 0.2%-0.3%, Mulberry
Leaf extract content is that 0.2%-0.3% effect is more excellent.
3, for gingival hemorrhage
Specifically, the volunteer randomly selecting 550 gingival hemorrhages is divided into 11 groups at random, carries out using and verifies, three days
The number of rear statistics different-effect, effect is divided into gingival hemorrhage transference cure, gingival hemorrhage substantially to suppress, slightly alleviates and nothing
Effect.Concrete as shown in table 3.
Gingival hemorrhage effect treated by table 3
| Group | Transference cure | Substantially suppression | Slightly alleviate | Invalid |
| Embodiment 1 | 15 | 20 | 15 | 0 |
| Embodiment 2 | 8 | 12 | 25 | 5 |
| Embodiment 3 | 10 | 15 | 23 | 2 |
| Embodiment 4 | 5 | 10 | 22 | 13 |
| Embodiment 5 | 14 | 18 | 17 | 1 |
| Embodiment 6 | 12 | 16 | 18 | 4 |
| Embodiment 7 | 13 | 17 | 17 | 3 |
| Embodiment 8 | 11 | 15 | 19 | 5 |
| Matched group 1 | 0 | 0 | 2 | 48 |
| Matched group 2 | 5 | 7 | 20 | 18 |
| Matched group 3 | 4 | 6 | 20 | 20 |
From table 3 it can be seen that there is the effect of collaborative enhancing, to tooth between each raw material of toothpaste for preparing of the embodiment of the present invention
The effect of gingival hemorrhage is substantially better than and is used alone or both carry with the use of Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract and Folium Perillae
Take thing, and, in toothpaste, Ilex purpurea Hassk.[I.chinensis Sims content is 0.4%-0.6%, and Folium perillae extract content is 0.2%-0.3%,
Folium Mori extract content is that 0.2%-0.3% effect is more excellent.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's
May be made that in the case of spirit and scope many other change and amendment.It is, therefore, intended that in the following claims
Including all such changes and modifications belonged in the scope of the invention.
Claims (10)
1. a toothpaste, it is characterised in that main by Ilex purpurea Hassk.[I.chinensis Sims, Folium perillae extract, Folium Mori extract and adjuvant
Make；
Wherein, it is 0.1%-1% that described Ilex purpurea Hassk.[I.chinensis Sims accounts for the percetage by weight of described toothpaste, and described Folium perillae extract accounts for
The percetage by weight of described toothpaste is 0.1%-1%, and it is 0.1%-that described Folium Mori extract accounts for the percetage by weight of described toothpaste
1%.
Toothpaste the most according to claim 1, it is characterised in that described Ilex purpurea Hassk.[I.chinensis Sims accounts for the weight percent of described toothpaste
Number is 0.3%-0.8%, and it is 0.15%-0.5% that described Folium perillae extract accounts for the percetage by weight of described toothpaste, described Folium Mori
It is 0.15%-0.5% that extract accounts for the percetage by weight of described toothpaste.
Toothpaste the most according to claim 1, it is characterised in that described Ilex purpurea Hassk.[I.chinensis Sims accounts for the weight percent of described toothpaste
Number is 0.4%-0.6%, and it is 0.2%-0.3% that described Folium perillae extract accounts for the percetage by weight of described toothpaste, described Folium Mori
It is 0.2%-0.3% that extract accounts for the percetage by weight of described toothpaste.
4. according to the toothpaste described in any one of claim 1-3, it is characterised in that described adjuvant at least includes abrasivus, thickening
Agent, excipient, wetting agent, foaming agent, adhesive, sweeting agent, preservative and deionized water；Alternatively, also include that essence eases up
Erosion agent.
Toothpaste the most according to claim 4, it is characterised in that described abrasivus is silicon dioxide, calcium bicarbonate, calcium carbonate
With any one or more in calcium phosphate dibasic dihydrate；
Described thickening agent is silicon dioxide；
Described excipient is Sorbitol；
Described wetting agent is glycerol or Polyethylene Glycol；
Described essence is Mint Essence or Herba Menthae Rotundifoliae essence；
Described foaming agent is sodium laurylsulfate；
Described adhesive is any one or more in hydroxyethyl cellulose, sodium carboxymethyl cellulose, carrageenan and cellulose gum；
Described sweeting agent is saccharin sodium；
Described corrosion inhibiter is sodium pyrophosphate；
Described preservative is sodium benzoate.
Toothpaste the most according to claim 5, it is characterised in that percentage, in described toothpaste, described friction
The content of agent is 10%-50%, and the content of described thickening agent is 5%-20%, and the content of described excipient is 20%-50%, institute
The content stating wetting agent is 2%-10%, and the content of described essence is 0%-2%, and the content of described foaming agent is 1%-5%, institute
The content stating adhesive is 1%-5%, and the content of described sweeting agent is 0.1%-1%, and the content of described preservative is 0.1%-
0.5%, surplus is deionized water.
Toothpaste the most according to claim 5, it is characterised in that percentage, in described toothpaste, described friction
The content of agent is 10%-50%, and the content of described thickening agent is 5%-30%, and the content of described excipient is 20%-50%, institute
The content stating wetting agent is 2%-10%, and the content of described essence is 0%-2%, and the content of described foaming agent is 1%-5%, institute
The content stating adhesive is 1%-5%, and the content of described sweeting agent is 0.1%-1%, and the content of described corrosion inhibiter is 0.1%-
0.5%, the content of described preservative is 0.1%-0.5%, and surplus is deionized water.
8. according to the preparation method of the toothpaste described in any one of claim 1-7, it is characterised in that comprise the following steps:
A (), preparation are containing adhesive and the first mixed liquor of excipient, preparation is containing Ilex purpurea Hassk.[I.chinensis Sims, Folium Mori extract, purple
Second mixed liquor of Folium Perillae extract, sweeting agent, corrosion inhibiter, preservative and wetting agent；
(b), by described first mixed liquor and described second mixed liquor mixing, obtain colloidal thing；
C (), addition abrasivus and thickening agent, addition foaming agent after mixing, mixing in described colloidal thing, add essence, mixed
Even, obtain described toothpaste after homogenizing；
If adjuvant does not include essence and corrosion inhibiter, then corresponding step is omitted.
Preparation method the most according to claim 8, it is characterised in that in step (c), mixing is all entered in vacuum water-bath
OK.
Preparation method the most according to claim 8, it is characterised in that in step (c), the time of described homogenizing is
1.5-2.0 hour.
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| CN106109357B (en) | 2019-04-12 |
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