CN107496329A - One kind compounding natural whiting toothpaste and preparation method thereof - Google Patents

Abstract

The present invention relates to Cosmetic Manufacture field, and in particular to one kind compounding natural whiting toothpaste and preparation method thereof, includes by weight：Pounce 5%~55%, Fragaia ananassa Duchesne extract 0.2%~2%, pyrophosphate 0.1%~2%, purple perilla leaf extract 0.8%~5%, rubbing agent 5%~35%, NMF 20%~60%, foaming agent 1.5%~3%, sweetener 0.5%~3%, thickener 1%~2%, flavouring agent 0.8%~2% and according to the needs of mouthfeel and odor type with addition of flavor enhancement, remaining is deionized water.The present invention is using pounce, pyrophosphate, Fragaia ananassa Duchesne extract as whitening, hemostasis, nutrition gum, reparation main component, it is added to extractive of perilla as sterilization, antiallergy, smelling removal composition in toothpaste, hence it is evident that improve the oral problems such as the whitening effect of toothpaste, sterilization, bleeding gums, anti-inflammatory, the damaged reparation in oral cavity, halitosis.

Description

One kind compounding natural whiting toothpaste and preparation method thereof

Technical field

The present invention relates to Cosmetic Manufacture field, and in particular to one kind compounding natural whiting toothpaste and preparation method thereof.

Background technology

Charming smile needs to mix pure white tooth naturally, but is corroded throughout the year by various swills, and tooth is but Gradually turning yellow.Usually our toothpaste used of brushing teeth really can not obtain tooth brush very clean, tooth yellowing or hair It is black still worried always we, and tooth Huang usually turns into the laughing stock of people, gives people a kind of very dirty and slovenly sensation, and this makes We are awkward endlessly, and the opposite pure white shellfish tooth of a bite can allow the image of a people, smile more outstanding, self-confident.It is because busy Work and allegro life people is not had the time in more leisure to dental prophylaxis, and frequent toothwash can also damage tooth Tooth, tooth is become very sensitive, this also into people it is very worried the problem of.

And in the prior art, although many toothpaste is to brag about that whitening function can be played, in general toothpaste be only by The compositions such as abrasive, purificant, wetting agent, preservative, aromatic form, and the principle of its whitening is also only cleaning and corrosion-resistant Basic role, and the mode cleaned is also extremely come to the surface, and is then done for the discoloration for extending into tooth certain depth without any Method, it can not really realize the function of whitening.

Cuttlebone calcium carbonate more than 85%, in addition, containing 17 kinds of ammonia such as methionine, asparatate, glutamic acid in inner casing Base acid.With astringing to arrest bleeding, treating spontaneous emission and leukorrhagia, relieving haperacidity analgesic, hygroscopic sore.Haematemesis is cured mainly, spitting blood, uterine bleeding, is had blood in stool, bleeding from five sense organs or subcutaneous tissue, wound Hinder bleeding；The emission and spermatorrhea of the unconsolidation of the kidney-qi, leukorrhea with reddish discharge；Have a stomachache noisy, belch pantothenic acid；Eczema ulcer.

Pyrophosphate phosphate is one of natural component of nearly all food, is added as important food ingredient and function Agent is added to be widely used in food processing.Water softener, boiler detergent, metal antirusting agent, juice purification agent etc. can be used as.

Strawberry is the rose family, Fragaria perennial herb.It is very rich containing multivitamin, especially Vitamin C content Richness, it or a kind of natural fruit of tooth-whitening, it can reduce internal heat, relieving summer-heat, heat-clearing can also treat erosion of mucous membrane in the oral cavity etc..

Purple perilla is usually used in Chinese medicine in China, a small number of areas also it is useful it make vegetables or enter tea.Ancient medical book《Synopsis Golden Chamber》 Carrying food fish and crab poisoning, " purple perilla liquor drinks it, and perilla leaf is also perilla leaf, has relieving exterior syndrome and dispelling cold, the function of relieving QI stagnancy in the stomach, can treat feed Fish and crab poisoning (including allergy) and there is stomachache, vomiting, or rubella itch person all over can be alone or with ginger, root of Dahurain angelica decoction.

The content of the invention

It is an object of the invention to provide one kind compounding natural whiting toothpaste and preparation method thereof, solves the toothpaste in current city White-skinned face function is poor, can not realize profound level whitening function the problem of.

To solve above-mentioned technical problem, the present invention uses following technical scheme：

One kind compounding natural whiting toothpaste, includes by weight：Pounce 5%~55%, Fragaia ananassa Duchesne extract 0.2%~ 2%, pyrophosphate 0.1%~2%, purple perilla leaf extract 0.8%~5%, rubbing agent 5%~35%, NMF 20%~ 60%, foaming agent 1.5%~3%, sweetener 0.5%~3%, thickener 1%~2%, flavouring agent 0.8%~2% and root According to the needs of mouthfeel and odor type with addition of flavor enhancement, remaining is deionized water.

Further technical scheme is：The NMF is the one or more in sorbierite, glycerine, polyethylene glycol, xylitol.

Further technical scheme is：The foaming agent is sodium lauryl sulfate, sodium cocoyl glycinate, dodecyl sulphur One or more in sour sodium, sodium lauryl sulfate, coconut palm osmanthus acylsarcosine sodium.

Further technical scheme is：The thickener is guar gum, xanthan gum, carragheen, hydroxyethyl ether cellulose, fibre Tie up the one or more in plain glue.

Further technical scheme is：The sweetener is one kind in saccharin sodium, Aspartame, stevioside, honey element It is or a variety of.

Further technical scheme is：The flavouring agent is in Green tea essence, Mint Essence, orange flavor, Chinese ilex essence One kind.

The method for preparing above-mentioned compounding natural whiting toothpaste, comprises the following steps：

Prepare the method that natural whiting toothpaste is compounded described in claim 1~6 any one, it is characterised in that including following Step：

Step 1: rubbing agent, thickener, pounce it is well mixed after, and be made on the surface plus foaming agent standby Use powder；

Step 2: after adding deionized water, Fragaia ananassa Duchesne extract, pyrophosphate, sweetener into vacuum cream pot, add Purple perilla extract solution is well mixed, and vacuumizes cream processed；

Step 3: after NMF is well mixed into oil cauldron the inside, squeeze into vacuum cream pot；

Step 4: after the water item in vacuum cream pot and oily item stir, stir while add standby powder, Powder continues to be stirred under vacuum after adding；

Step 5: after being stirred under vacuum 25-30 minutes, add flavouring agent and continue to stir；

Step 6: after being stirred under vacuum 10~15 minutes, stop stirring vacuum and deaerate to obtain lotion of toothpaste, carry out aseptic tank Dress, complete to prepare.

Compared with prior art, the beneficial effects of the invention are as follows：By pounce, pyrophosphate, extractive of perilla, strawberry Extract as improve toothpaste whitening effect, prevent and prevent bleeding gums, nutrition gum, oral cavity are damaged repairs, sterilizes, anti-mistake The main component such as quick, it is added to using four kinds of compositions as functional component and indispensable part in toothpaste.

Embodiment

In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.

Embodiment 1：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Sorbierite (NMF) 45%, glycerine (NMF) 10%, cellulose gum (thickener) 0.8%, xanthan gum (thickener) 0.7%, lauryl sodium sulfate (foaming agent) 2.2%th, Mint Essence (flavouring agent) 0.8%, Fragaia ananassa Duchesne extract 0.2%, pyrophosphate 0.2%, pounce 5%, perilla leaf Extract solution 1.2%, saccharin sodium (sweetener) 0.5%, silica (rubbing agent) 25%, deionized water 8.4%.

Preparation process：

First by saccharin sodium (sweetener) 0.05kg, purple perilla leaf extract 0.12kg, Fragaia ananassa Duchesne extract 0.02kg, pyrophosphate 0.02kg is dissolved in 0.84kg water, with vacuum suck Manufacturing medicine extract machine in, with glycerine (NMF) 1kg squeezed into Manufacturing medicine extract machine, Sorbierite (NMF) 4.5kg is mixed into the aqueous solution, then silica (rubbing agent) 2.5kg, pounce 0.5kg, Cellulose gum (thickener) 0.08kg, xanthan gum (thickener) 0.07kg, lauryl sodium sulfate (foaming agent) 0.22kg are mixed, It is sent into Manufacturing medicine extract machine, vacuum high-speed stirred adds Mint Essence (flavouring agent) 0.08kg, continuing stirring 10 after 25~30 minutes ~15 minutes, mix, vacuum outgas, obtain lotion of toothpaste, after standing 30 minutes, pass through sterile filling and packaging.

Embodiment 2：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Glycerine (NMF) 24%, poly- second two Alcohol (NMF) 10%, carragheen (thickener) 1.1%, sodium lauryl sulfate (foaming agent) 1.3%, Green tea essence (flavouring agent) 1.2%th, Fragaia ananassa Duchesne extract 0.3%, pounce 10%, pyrophosphate 0.5%, purple perilla leaf extract 0.8%, saccharin sodium (sweet tea Taste agent) 1%, silica (rubbing agent) 10%, calcium monohydrogen phosphate 30%, deionized water 9.8%.

Preparation process：

First by saccharin sodium (sweetener) 0.1kg, purple perilla leaf extract 0.08kg, Fragaia ananassa Duchesne extract 0.03kg, pyrophosphate 0.05kg is dissolved in 0.98kg deionized water, is sucked with vacuum in Manufacturing medicine extract machine, (is protected with the polyethylene glycol squeezed into Manufacturing medicine extract machine Humectant) 1kg, glycerine (NMF) 2.4kg be mixed into the aqueous solution, then silica (rubbing agent) 1kg, pounce 1kg, calcium monohydrogen phosphate 3kg, carragheen (thickener) 0.11kg, sodium lauryl sulfate (foaming agent) 0.13kg are mixed, and are sent into cream processed In machine, vacuum high-speed stirred adds Green tea essence (flavouring agent) 0.1kg, is continuing stirring 10~15 minutes after 25~30 minutes, Mix, vacuum outgas, obtain lotion of toothpaste, after standing 30 minutes, pass through sterile filling, packaging.

Embodiment 3：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Sorbierite (NMF) 15%, xylose Alcohol (NMF) 35%, Fragaia ananassa Duchesne extract 0.6%, hydroxyethyl ether cellulose (thickener) 1%, xanthan gum (thickener) 0.6%, Sodium cocoyl glycinate (foaming agent) 1.5%, pounce 15%, pyrophosphate 0.8%, purple perilla leaf extract 1%, phosphoric acid hydrogen Calcium 15%, Aspartame (sweetener) 2%, Chinese ilex essence (flavouring agent) 1.2%, deionized water 11.81%.

Preparation process：

First by Aspartame (sweetener) 0.2kg, purple perilla leaf extract 0.1kg, Fragaia ananassa Duchesne extract 0.06kg, pyrophosphate 0.08kg is dissolved in 1.181kg deionized water, is sucked with vacuum in Manufacturing medicine extract machine, (is protected with the xylitol squeezed into Manufacturing medicine extract machine Humectant) 3.5kg, sorbierite (NMF) 1.5kg be mixed into the aqueous solution, then calcium monohydrogen phosphate 1.5kg, pounce 1.5kg, Hydroxyethyl ether cellulose (thickener) 0.1kg, xanthan gum (thickener) 0.06kg, sodium cocoyl glycinate (foaming agent) 0.15kg Mix, be sent into Manufacturing medicine extract machine, vacuum high-speed stirred adds Chinese ilex essence (flavouring agent) 0.12kg, stirred after 25~30 minutes 10~15 minutes, mix, vacuum outgas, obtain lotion of toothpaste, after standing 30 minutes, pass through sterile filling, packaging.

Embodiment 4：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Glycerine (NMF) 32%, ethoxy Cellulose 1.8%, silica (rubbing agent) 10%, calcium carbonate 25%, pounce 11%, pyrophosphate 1.2%, perilla leaf Extract solution 2%, coconut palm osmanthus acylsarcosine sodium (foaming agent) 2%, Aspartame (sweetener) 1%, Fragaia ananassa Duchesne extract 0.45%, orange Essence (flavouring agent) 1.1%, deionized water 12.45%.

Preparation process：

First by Aspartame (sweetener) 0.1kg, purple perilla leaf extract 0.2kg, Fragaia ananassa Duchesne extract 0.045kg, pyrophosphoric acid Salt 0.12kg is dissolved in 1.245kg deionized water, is sucked with vacuum in Manufacturing medicine extract machine, with the sorbierite squeezed into Manufacturing medicine extract machine (NMF) 4.5kg is mixed into the aqueous solution, then silica (rubbing agent) 1kg, pounce 1.1kg, calcium carbonate 2.5kg, hydroxyethyl cellulose 0.18kg, coconut palm osmanthus acylsarcosine sodium (foaming agent) 0.2kg are mixed, and are sent into Manufacturing medicine extract machine, and vacuum is high After speed stirring 25~30 minutes, orange flavor (flavouring agent) 0.11kg is added, in stirring 10~15 minutes, is mixed, vacuum outgas, Lotion of toothpaste is obtained, after standing 30 minutes, passes through sterile filling, packaging.

Embodiment 5：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Xylitol (NMF) 15%, poly- second Glycol (NMF) 20%, sodium dodecyl sulfate 1%, sodium cocoyl glycinate (foaming agent) 0.5%, sodium dihydrogen phosphate 0.1%, Pounce 20%, pyrophosphate 1.6%, purple perilla leaf extract 2.5%, sodium benzoate 0.5%, xanthan gum (thickener) 1%, Carragheen (thickener) 0.5%, calcium carbonate 30%, saccharin sodium (sweetener) 0.6%, Fragaia ananassa Duchesne extract 1.5%, Chinese ilex essence (flavouring agent) 2%, deionized water 3.2%.

Preparation process：

First by saccharin sodium (sweetener) 0.06kg, pyrophosphate 0.16kg, Fragaia ananassa Duchesne extract 0.15kg, purple perilla leaf extract 0.25kg is dissolved in 0.32kg ionized water, is sucked with vacuum in Manufacturing medicine extract machine, with the polyethylene glycol (moisturizing squeezed into Manufacturing medicine extract machine Agent) 2kg, xylitol (NMF) 1.5kg be mixed into the aqueous solution, calcium carbonate 3kg, pounce 2kg, xanthan gum (thickening Agent) 0.1kg, carragheen (thickener) 0.05kg, lauryl sodium sulfate (foaming agent) 0.1kg, sodium cocoyl glycinate (foaming Agent) 0.05kg mixings, it is sent into Manufacturing medicine extract machine, vacuum high-speed stirred adds spearmint essence 0.1kg, stirred after 25~30 minutes 10~15 minutes, mix, vacuum outgas, obtain lotion of toothpaste, after standing 30 minutes, pass through sterile filling, packaging.

Embodiment 6：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Glycerine (NMF) 15%, poly- second two Alcohol (NMF) 8%, sodium dodecyl sulfate 2%, cellulose gum (thickener) 1%, carragheen (thickener) 0.5%, cuttlebone Powder 17%, pyrophosphate 1.8%, purple perilla leaf extract 3%, silica (rubbing agent) 20%, calcium monohydrogen phosphate 15%, stevioside (sweetener) 1%, Fragaia ananassa Duchesne extract 0.5%, Green tea essence (flavouring agent) 2%, ionized water 13.2%.

Preparation process：

First by stevioside (sweetener) 0.1kg, Fragaia ananassa Duchesne extract 0.05kg, pyrophosphate 0.18kg, purple perilla leaf extract 0.3kg is dissolved in 1.32kg deionized waters, is sucked with vacuum in Manufacturing medicine extract machine, with the glycerine (NMF) squeezed into Manufacturing medicine extract machine 1.5kg, polyethylene glycol (NMF) 2kg are mixed into the aqueous solution, then silica (rubbing agent) 2kg, pounce 1.7kg, calcium monohydrogen phosphate 3kg, cellulose gum (thickener) 0.1kg, carragheen (thickener) 0.05kg, lauryl sodium sulfate (foaming agent) 0.2kg is mixed, and is sent into Manufacturing medicine extract machine, and vacuum high-speed stirred adds Green tea essence (flavouring agent) after 25~30 minutes 0.2kg, stirring 10~15 minutes, mix, vacuum outgas, obtain lotion of toothpaste, stand 30 minutes after, by sterile filling, Packaging.

Embodiment 7：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Xylitol (NMF) 43%, poly- second Glycol (NMF) 4%, cellulose gum (thickener) 0.5%, hydroxyethyl ether cellulose (thickener) 1.5%, the sweet ammonia of cocounut oil acyl Sour sodium (foaming agent) 1.5%, pyrophosphate 2%, pounce 11.5%, purple perilla leaf extract 1.5%, sodium lauryl sulfate (foaming agent) 1%, Fragaia ananassa Duchesne extract 0.8%, Mint Essence (flavouring agent) 1.5%, saccharin sodium (sweetener) 2%, calcium monohydrogen phosphate 26%th, deionized water 3.2%.

Preparation process：

First by saccharin sodium (sweetener) 0.05kg, pyrophosphate 0.2kg, Fragaia ananassa Duchesne extract 0.08kg, purple perilla leaf extract 0.15kg is dissolved in 0.32kg deionized water, is sucked with vacuum in Manufacturing medicine extract machine, with the xylitol (moisturizing squeezed into Manufacturing medicine extract machine Agent) 4.3kg, polyethylene glycol (NMF) 0.4kg be mixed into the aqueous solution, then calcium monohydrogen phosphate 2.6kg, pounce 1.15kg, hydroxyethyl cellulose 0.15kg, cellulose gum (thickener) 0.05kg, sodium cocoyl glycinate (foaming agent) 0.15kg, sodium lauryl sulfate (foaming agent) 0.1kg, mixing, it to be sent into Manufacturing medicine extract machine, vacuum high-speed stirred is after 25~30 minutes, Mint Essence (flavouring agent) 0.15kg is added, in stirring 10~15 minutes, mixes, vacuum outgas, obtains lotion of toothpaste, stand 30 After minute, pass through sterile filling, packaging.

Embodiment 8：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Sorbierite (NMF) 24%, xylose Alcohol (NMF) 24%, xanthan gum (thickener) 1%, cellulose gum (thickener) 1%, lauryl sodium sulfate (foaming agent) 1.3%th, coconut palm osmanthus acylsarcosine sodium (foaming agent) 1.5%, pounce 9.8%, pyrophosphate 1.5%, purple perilla leaf extract 4%th, Chinese ilex essence (flavouring agent) 0.8%, Fragaia ananassa Duchesne extract 1%, honey element (sweetener) 1%, calcium monohydrogen phosphate 11%, calcium carbonate 11%th, deionized water 7.1%.

Preparation process：

First by honey element (sweetener) 0.1kg, purple perilla leaf extract 0.4kg, Fragaia ananassa Duchesne extract 0.1kg, pyrophosphate 0.15kg is dissolved in 0.71kg deionized water, is sucked with vacuum in Manufacturing medicine extract machine, with the xylitol (moisturizing squeezed into Manufacturing medicine extract machine Agent) 2.4kg, sorbierite (NMF) 2.4kg be mixed into the aqueous solution, then calcium carbonate 1.1kg, calcium monohydrogen phosphate 1.1kg, ink Fishbone dust 9.8kg, xanthan gum (thickener) 0.1kg, cellulose gum (thickener) 0.1kg, lauryl sodium sulfate (foaming agent) 0.13kg, coconut palm osmanthus acylsarcosine sodium (foaming agent) 0.15kg are mixed, and are sent into Manufacturing medicine extract machine, vacuum high-speed stirred 25~30 minutes Afterwards, Chinese ilex essence (flavouring agent) 0.08kg is added, in stirring 10~15 minutes, is mixed, vacuum outgas, obtains lotion of toothpaste, it is quiet After putting 30 minutes, pass through sterile filling, packaging.

Embodiment 9：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Sorbierite (NMF) 50%, Chinese life Glue (thickener) 2%, lauryl sodium sulfate (foaming agent) 1.9%, pounce 30.3%, purple perilla leaf extract 2.8%, Jiao Phosphate 0.9%, Chinese ilex essence (flavouring agent) 2%, Fragaia ananassa Duchesne extract 1.3%, honey element (sweetener) 1.2%, calcium monohydrogen phosphate 5%th, deionized water 2.6%.

Preparation process：

First by honey element (sweetener) 0.12kg, pyrophosphate 0.35kg, Fragaia ananassa Duchesne extract 0.13kg, purple perilla leaf extract 0.28kg is dissolved in 0.26kg deionized waters, is sucked with vacuum in Manufacturing medicine extract machine, with the sorbierite (moisturizing squeezed into Manufacturing medicine extract machine Agent) 5kg is mixed into the aqueous solution, then calcium monohydrogen phosphate 0.5kg, xanthan gum (thickener) 0.2kg, pounce 30.3kg, Lauryl sodium sulfate (foaming agent) 0.19kg is mixed, and is sent into Manufacturing medicine extract machine, and vacuum high-speed stirred adds green after 25~30 minutes Tea perfume essence (flavouring agent) 0.2kg, in stirring 10~15 minutes, mix, vacuum outgas, obtain lotion of toothpaste, after standing 30 minutes, Pass through sterile filling, packaging.

Embodiment 10：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Polyethylene glycol (NMF) 25%, wood Sugar alcohol (NMF) 30%, guar gum (thickener) 0.6%, cellulose gum (thickener) 1%, sodium cocoyl glycinate (foaming Agent) 2.1%, pounce 7.2%, pyrophosphate 1.8%, purple perilla leaf extract 3.5%, Chinese ilex essence (flavouring agent) 0.8%, Fragaia ananassa Duchesne extract 1.6%, honey element (sweetener) 1%, calcium monohydrogen phosphate 5%, calcium carbonate 15%, deionized water 5.4%.

Preparation process：

First by honey element (sweetener) 0.1kg, pyrophosphate 0.18kg, Fragaia ananassa Duchesne extract 0.16kg, purple perilla leaf extract 0.35kg is dissolved in 0.54kg deionized water, is sucked with vacuum in Manufacturing medicine extract machine, with the xylitol (moisturizing squeezed into Manufacturing medicine extract machine Agent) 3kg, polyethylene glycol (NMF) 2.5kg be mixed into the aqueous solution, then calcium carbonate 1.5kg, pounce 0.72kg, Calcium monohydrogen phosphate 0.5kg, guar gum (thickener) 0.06kg, cellulose gum (thickener) 0.1kg, sodium cocoyl glycinate (foaming agent) 0.21kg is mixed, and is sent into Manufacturing medicine extract machine, and vacuum high-speed stirred adds orange flavor (flavouring agent) 0.08kg after 25~30 minutes, In stirring 10~15 minutes, mix, vacuum outgas, obtain lotion of toothpaste, after standing 30 minutes, pass through sterile filling, packaging.

Embodiment 11：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Sorbierite (NMF) 60%, Guar Glue (thickener) 1.6%, sodium lauryl sulfate (foaming agent) 1%, coconut palm osmanthus acylsarcosine sodium (foaming agent) 1.5%, pounce 21.8%th, pyrophosphate 1%, purple perilla leaf extract 4.5%, Chinese ilex essence (flavouring agent) 0.8%, Mint Essence (flavouring agent) 1%th, Fragaia ananassa Duchesne extract 1.8%, honey element (sweetener) 1%, saccharin sodium (sweetener) 0.5%, deionized water 3.5%.

Preparation process：

First by honey element (sweetener) 0.1kg, saccharin sodium (sweetener) 0.05kg, pyrophosphate 0.1kg, Fragaia ananassa Duchesne extract 0.18kg, purple perilla leaf extract 0.45kg are dissolved in 0.35kg deionized waters, with vacuum suck Manufacturing medicine extract machine in, with squeeze into cream processed Sorbierite (NMF) 6kg in machine is mixed into the aqueous solution, then pounce 2.18kg, guar gum (thickener) 0.16kg, sodium lauryl sulfate (foaming agent) 0.1kg, coconut palm osmanthus acylsarcosine sodium (foaming agent) 0.15kg are mixed, and are sent into Manufacturing medicine extract machine In, vacuum high-speed stirred adds Chinese ilex essence (flavouring agent) 0.08kg, Mint Essence (flavouring agent) 0.1kg after 25~30 minutes, In stirring 10~15 minutes, mix, vacuum outgas, obtain lotion of toothpaste, after standing 30 minutes, pass through sterile filling, packaging.

Embodiment 12：

One kind compounding natural whiting toothpaste, chooses the following component of percentage by weight：Sorbierite (NMF) 20%, OK a karaoke club Glue (thickener) 1%, hydroxyethyl ether cellulose (thickener) 0.9%, sodium cocoyl glycinate (foaming agent) 1.5%, coconut palm osmanthus acyl Sodium sarcosinate (foaming agent) 1.5%, pounce 55%, purple perilla leaf extract 5%, pyrophosphate 2%, Fragaia ananassa Duchesne extract 2%, Green tea essence (flavouring agent) 0.8%, orange flavor (flavouring agent) 1.2, honey element (sweetener) 1%, Aspartame (sweetener) 0.8%th, deionized water 7.3%.

Preparation process：

First honey element (sweetener) 0.1kg, Aspartame (sweetener) 0.08kg, pyrophosphate 0.2kg, perilla leaf are carried Take liquid 0.5kg to be dissolved in 0.73kg deionized waters, sucked with vacuum in Manufacturing medicine extract machine, (protected with the sorbierite squeezed into Manufacturing medicine extract machine Humectant) 2kg is mixed into the aqueous solution, then pounce 5.5kg, carragheen (thickener) 0.1kg, hydroxyethyl ether cellulose (thickener) 0.09kg, sodium cocoyl glycinate (foaming agent) 0.15kg, coconut palm osmanthus acylsarcosine sodium (foaming agent) 0.15kg are mixed, It is sent into Manufacturing medicine extract machine, vacuum high-speed stirred adds Green tea essence (flavouring agent) 0.08kg, Fragaia ananassa Duchesne extract after 25~30 minutes 0.2kg, orange flavor (flavouring agent) 0.12kg, in stirring 10~15 minutes, mix, vacuum outgas, obtain lotion of toothpaste, stand After 30 minutes, pass through sterile filling, packaging.

The using effect entered below with the practical effect and ordinary toothpaste of present invention compounding natural whiting toothpaste is entered Row contrast, to carry out effect explanation：

1. subject enrollment condition is as follows:

(1) age:18~70 years old, health, the not allergies to tried toothpaste component or special sign.

(2) mouth front must at least 12 complete teeth, do not influence dental exogenous mottle scoring situation, Such as:Extensive dental repair, endogenous tooth staining and artificial corona.

(3) subject can complete entirely to test, and sign informed consent form.Experiment must be ratified through the independent assessment committee.

(4) subject should have some habits and customs that can deepen he or she's color of teeth, such as:Hobby is drunk coffee, tea With red wine or use tobacco product.When being selected in, all subjects must carry out the inspection of dental exogenous mottle.

(5) following personnel can not be selected in:Using orthodontic apparatus, there is more than one incisor to have corona or repaiied through covering The tumour, moderate or the serious periodontal disease that adorn, have oral cavity hard and soft tissue, the dental caries damage having at 5 or more, in addition, pregnancy or feed Newborn women and the personnel of the other clinical tests of participation can not be selected in.

2. experimental design

It is all to issue the toothpaste that subject uses and all use blank sheet of paper to ensure that this experiment can be carried out fully according to the requirement of double blinding Parcel.Experiment brush with soft toothbrush used is also provided by clinical trial investigator.By clinical test regulation subject with giving Fixed toothpaste and toothbrush, once in the morning and once at night, one minute every time.Subject need not change oneself original habit of brushing teeth It is used, but can not be again with other dentifrices.All subjects need to receive the inspection of dental exogenous mottle again after 6 weeks.Inspection Inquire subject whether there is the discomfort in any oral cavity when looking into, examiner is also needed to check the hard and soft tissue of subject oral cavity, appointed with record The generation of what adverse reaction.

2.1 clinical score steps

To reduce the difference of scoring, the examiner during whole experiment can only be same people, must not change.Evaluation method For Lobene color spot indexes.This method need to measure before lower jaw the buccal surface of 6 teeth before the buccal surface and lingual surface and the upper jaw of 6 teeth Color spot area and color spot depth, are shown in Table 1.

Table 1：Lobene color spots index score principle

Index	Color spot depth	Index	Color spot area
				0	Non-coloring	0	Without color spot
1	Light colored, yellow or brown	1	Color spot area is less than 1/3
				2	Moderate colours, brown	2	Color spot area is more than 2/3
3	Severe colours, black or dark-brown	3	Color spot area is more than 2/3

2.2 statistical method

Two groups of results are analyzed with covariance method, significance 0.05.

2.3 result

Share 80 subjects and complete whole experiment, sex and the age point of subject by the requirement of clinical trial protocol Cloth table is shown in Table 2.Difference statistically is found no, the reason for subject exits experiment is unrelated with toothpaste used.On inspection The adverse reaction of any oral hard tissue is found no, subject does not report any adverse reaction yet.

Table 2：The age of the subject of completed 6 weeks experiment and Sex distribution

3.1 baselines check data

Table 3 is the result of the Lobene color spot indexes when baseline checks.The average value of Liang Ge treatment groups color spot area index All it is 1.65.The average value of color spot depth factor, effect plus whitening toothpaste are 1.81 to Colgate-Palmolive entirely, and Colgate-Palmolive imitates toothpaste and is entirely 1.79.Through statistical analysis, without difference statistically between two groups.

Table 3：Lobene color spots area index and color spot depth factor when baseline checks

Data after 3.2 treatments 6 weeks

Treat the data after 6 weeks and be shown in Table 4.Exogenous color spot area index, this natural whiting toothpaste are 0.67, ordinary toothpaste For 1.35.Through statistical analysis, there is significant statistically difference (P between two groups<0.05), the natural whiting compared with ordinary toothpaste Toothpaste can reduce exogenous color spot area 50.4%；Compared with when being checked with group baseline, exogenous color spot area have dropped 59.4%.

Table 4：Lobene color spots area index and color spot depth factor after treating 6 weeks

Dental exogenous mottle depth, it is respectively 0.74 in this natural whiting toothpaste group and ordinary toothpaste group after treating 6 weeks With 1.45, both are compared to declining 49.0% (P<0.05).Compared with when baseline checks, toothpaste external source can be reduced in natural whiting group Property color spot depth 59.1%.

As a result show that this clinical test compares effect of two kinds of toothpaste in terms of dental exogenous mottle is controlled.As a result table It is bright:Compared with ordinary toothpaste, after this natural whiting toothpaste 6 weeks, dental exogenous mottle area and tooth are exogenous with spot It is deeply main to drop 50.4% and 49.0% respectively.Compared with when baseline checks, dental exogenous mottle area and the exogenous color of tooth Spot depth can reduce by 59.4% and 59.1% respectively.Therefore result of the test can be supported to draw a conclusion:Sheet containing pounce Natural whiting toothpaste can effectively remove the exogenous color spot of tooth.

Although reference be made herein to invention has been described for multiple explanatory embodiments of the invention, however, it is to be understood that Those skilled in the art can be designed that a lot of other modifications and embodiment, and these modifications and embodiment will fall in this Shen Please be within disclosed spirit and spirit.More specifically, can be to master in the range of disclosure and claim The building block and/or layout for inscribing composite configuration carry out a variety of variations and modifications.Except what is carried out to building block and/or layout Outside modification and improvement, to those skilled in the art, other purposes also will be apparent.

Claims (7)

1. one kind compounding natural whiting toothpaste, it is characterised in that include by weight：

Pounce 5%~55%,

Fragaia ananassa Duchesne extract 0.2%~2%,

Pyrophosphate 0.1%~2%,

Purple perilla leaf extract 0.8%~5%,

Rubbing agent 5%~35%,

NMF 20%~60%,

Foaming agent 1.5%~3%,

Sweetener 0.5%~3%,

Thickener 1%~2%,

Flavouring agent 0.8%~2%.

Remaining is deionized water.

A kind of 2. compounding natural whiting toothpaste according to claim 1, it is characterised in that：The NMF be sorbierite, One or more in glycerine, polyethylene glycol, xylitol.

A kind of 3. compounding natural whiting toothpaste according to claim 1, it is characterised in that：The foaming agent is lauryl alcohol sulphur One or more in sour sodium, sodium cocoyl glycinate, lauryl sodium sulfate, coconut palm osmanthus acylsarcosine sodium.

A kind of 4. compounding natural whiting toothpaste according to claim 1, it is characterised in that：The thickener be guar gum, One or more in xanthan gum, carragheen, hydroxyethyl ether cellulose, cellulose gum.

A kind of 5. compounding natural whiting toothpaste according to claim 1, it is characterised in that：The sweetener be saccharin sodium, One or more in Aspartame, stevioside, honey element.

A kind of 6. compounding natural whiting toothpaste according to claim 1, it is characterised in that：The flavouring agent is that green tea is fragrant One kind in essence, Mint Essence, orange flavor, Chinese ilex essence.

7. prepare the method that natural whiting toothpaste is compounded described in claim 1~6 any one, it is characterised in that including following step Suddenly：

Step 1: after rubbing agent, thickener, pounce are well mixed, and standby powder is made plus foaming agent on the surface Material；

Step 2: after adding deionized water, Fragaia ananassa Duchesne extract, pyrophosphate, sweetener into vacuum cream pot, purple perilla is added Extract solution is well mixed, and vacuumizes cream processed；

Step 3: after NMF is well mixed into oil cauldron the inside, squeeze into vacuum cream pot；

Step 4: after the water item in vacuum cream pot and oily item stir, stir while adding standby powder, powder Continue to be stirred under vacuum after addition；

Step 5: after being stirred under vacuum 25-30 minutes, add flavouring agent and continue to stir；

Step 6: after being stirred under vacuum 10~15 minutes, stop stirring vacuum and deaerate to obtain lotion of toothpaste, carry out aseptic canning, it is complete Into preparation.