CN101278893A - Chinese herbal medicine toothpaste containing Chinese herbal medicine active combination against Helicobacter pylori and method for producing the same - Google Patents
Chinese herbal medicine toothpaste containing Chinese herbal medicine active combination against Helicobacter pylori and method for producing the same Download PDFInfo
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- CN101278893A CN101278893A CNA2008100284065A CN200810028406A CN101278893A CN 101278893 A CN101278893 A CN 101278893A CN A2008100284065 A CNA2008100284065 A CN A2008100284065A CN 200810028406 A CN200810028406 A CN 200810028406A CN 101278893 A CN101278893 A CN 101278893A
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Abstract
The invention relates to Chinese medicinal herbal toothpaste comprising an anti-helicobacter pylori Chinese medicinal herbal active composition; the Chinese medicinal herbal toothpaste comprises a paste base and the anti-helicobacter pylori Chinese medicinal herbal active composition extracted by a supercritical CO2; wherein, the percentage of the Chinese medicinal herbal active composition accounted for the total weight of the Chinese medicinal herbal toothpaste is 0.5%-10%; and the remaining weight is the paste base. By adding the Chinese medicinal herbal active matter obtained by the technology of the supercritical CO2 extraction and separation into the toothpaste, the invention well solves the disadvantages of traditional extractive technique of the anti-helicobacter pylori Chinese medicinal herbal active composition, and the anti-helicobacter pylori Chinese medicinal herbal active composition with the definite composition is obtained; the purity of the anti-helicobacter pylori Chinese medicinal herbal active composition is very high, thereby being suitable for using as the medicated additive of the toothpaste. By adopting the invention, the Chinese medicinal herbal health care toothpaste which has high content of the anti-helicobacter pylori Chinese medicinal herbal active composition and good effect of inhibiting and killing the helicobacter pylori can be reliably obtained.
Description
Technical field
The present invention relates to a kind of articles for daily use, particularly relate to a kind of Chinese herbal toothpaste and manufacture method thereof that contains Chinese herbal medicine activity extract composition.
Background technology
At present, Chinese medicinal toothpaste kind daily on the market is a lot, it mainly is to add corresponding Chinese medicine ingredients to form Chinese medicinal toothpaste in the lotion of toothpaste substrate of forming toothpaste, it is used for multipotency and suppresses the oral cavity noxious bacteria, anti-inflammatory analgesic, anti-this desensitization, caries prevention, the control gingivitis, periodontitis, periodontals such as dental hemorrhage.And traditional lotion of toothpaste substrate mainly includes wetting agent, binding agent, abrasive, essence and glucide and balance of deionized water, and wherein wetting agent adopts glycerol or sorbitol or propylene glycol or Polyethylene Glycol or its combination; Binding agent adopts sodium carboxymethyl cellulose or carboxyethyl cellulose or carrageenan or HANSHENGJIAO or its combination; Abrasive adopts calcium carbonate or calcium hydrogen phosphate or silicon dioxide or its combination.(Helicobacter pylori is the pathogen that propagate in a kind of whole world Hp) to helicobacter pylori, is the The main pathogenic fungi of chronic active gastritis and peptic ulcer, with the multiple disease in digestive tract and oral cavity close ties is arranged.Oral plaque, gingival sulcus or periodontal pocket are the accumulative control environments of HP, and the helicobacter pylori that exists in the human oral cavity has certain pathogenic, promptly can cause diseases such as chronic gastritis, peptic ulcer to produce by oral infections.Active matter composition by the one or more combination in Herba Houttuyniae, Herba Taraxaci, Pericarpium Granati, the Herba Agrimoniae has excellent inhibition and kills the helicobacter pylori function, the disease treatments such as inside and outside section of medical science have been widely used in, therefore the drug effect of anti-helicobacter pylori Chinese herbal medicine active compound composition is applied to the oral cavity health nursing field and has positive effect, and the extracting method of traditional Herba Houttuyniae isoreactivity thing composition is water extraction method or ethanol extraction method or its two kinds of combined methods, and these methods all need to carry out the high temperature high cooking.Not only make the extraction ratio of Herba Houttuyniae isoreactivity thing composition low, and the color and luster of activity extract is darker.Owing to the steam temperature height, extraction time is long simultaneously, some thermal sensitivity active ingredient decomposition easily, oxidation or hydrolysis in the Herba Houttuyniae etc., and in addition, concentration process can make the extractum color burn behind the decocting in water.So the activity extract effective component content of the Herba Houttuyniae that these traditional extracting method make, Herba Taraxaci, Pericarpium Granati, Herba Agrimoniae etc. is not high, impurity is too many, and the color is too dark, the composition complexity.Not only influence the outward appearance of product when making an addition to it in toothpaste, and the active active ingredient of Herba Houttuyniae etc. can't be fully utilized also, recipe design is subjected to certain restriction.On formulation of toothpaste, select opaque resin and cover its ugly color except needs, also to solve the addition of activity extract of Herba Houttuyniae etc. and the problem of stability, increase simultaneously toothpaste again and produced aftertreatment technology, improved production cost, energy consumption greatly.Obviously, add in the toothpaste for these Herba Houttuyniae isoreactivity things that extract with traditional method for making, as desire to make the maximization useful effect of toothpaste performance medicine must strengthen addition, such toothpaste color is inevitable very dark, influences the mastic outward appearance; If want to keep the pure white preferably color of toothpaste, then the amount of medicated premix can not be too big, so often can not guarantee drug effect, so addition (drug effect) and mastic outward appearance and stability form a pair of implacable contradiction.
Summary of the invention
The objective of the invention is existence, provide a kind of supercritical CO at the problems referred to above
2The anti-helicobacter pylori Chinese herbal medicine active compound that extraction and separation technology extracts is applied in the toothpaste, makes the not only pure white exquisiteness of outward appearance of made toothpaste, need not to add opaque resin, and because of supercritical CO
2The anti-helicobacter pylori Chinese herbal medicine active compound purity height of extraction, both made Chinese medicinal toothpaste use effect can be fully guaranteed the Chinese herbal toothpaste and the manufacture method thereof that contain anti-helicobacter pylori Chinese herbal medicine active compound of made things convenient for recipe design again, improving the quality of products.
The objective of the invention is to be achieved through the following technical solutions:
A kind of Chinese herbal toothpaste that contains anti-helicobacter pylori Chinese herbal medicine active compound comprises lotion of toothpaste substrate and supercritical CO
2Extraction anti-helicobacter pylori Chinese herbal medicine active compound, wherein said supercritical CO
2The percentage ratio that extraction anti-helicobacter pylori Chinese herbal medicine active compound accounts for the Chinese herbal toothpaste gross weight is 0.5%～10%, and the surplus of described Chinese herbal toothpaste is a lotion of toothpaste substrate.
Wherein above-mentioned supercritical CO
2Extraction anti-helicobacter pylori Chinese herbal medicine active compound is a supercritical CO
2Extraction Herba Houttuyniae active matter or supercritical CO
2Extraction Herba Taraxaci active matter or supercritical CO
2Extraction Pericarpium Granati active matter or supercritical CO
2The supercritical CO of extraction Herba Agrimoniae active matter or its at least two kinds and two or more combinations
2The extraction active compound.
Above-mentioned lotion of toothpaste substrate comprises that accounting for the Chinese herbal toothpaste total weight percent is following constituent:
Wetting agent 20%～30% binding agent 1.5%～3.5%
Foaming agent 1.6%～3.0% abrasivus 40%～55%
Essence 1.2%～1.8% glucide 0.1%～0.4%
Surplus is a deionized water.
A kind of method of making said herbal medicine toothpaste may further comprise the steps:
(1) binding agent is joined in the wetting agent, stir and form finely dispersed suspension;
(2) glucide is added deionized water, be stirred to dissolving fully;
(3) liquor saccharini in wetting agent and the step (2) is joined suspension in the step (1), stir into transparent rubber cement;
(4) with the oil-soluble supercritical CO that passes through
2The Herba Houttuyniae of extraction or Herba Taraxaci or Pericarpium Granati or Herba Agrimoniae or its at least two kinds and two or more active compound are dissolved in essence;
(5) with abrasive, foaming agent and be dissolved with supercritical CO
2The essence of the Herba Houttuyniae of extraction or Herba Taraxaci or Pericarpium Granati or Herba Agrimoniae or its at least two kinds and two or more active compounds joins in the above-mentioned rubber cement, stir into paste, after grinding the degassing, obtain lotion of toothpaste again, and, be packaged to be the toothpaste finished product through aseptic process.
The present invention is owing to adopt supercritical CO
2The anti-helicobacter pylori Chinese herbal medicine active compound that extraction and separation technology extracts is applied in the toothpaste, because supercritical CO
2Extraction and separation technology, it is low to have temperature, without solvent, can separate to greatest extent and the characteristics of the composition of remaining valid, and is described as green isolation technics.Therefore the present invention is used for supercritical carbon dioxide extraction method the extraction of Herba Houttuyniae, Herba Taraxaci, Pericarpium Granati, Herba Agrimoniae isoreactivity thing dexterously, solved the defective of the active ingredient extractive technique of traditional Herba Houttuyniae etc. well, obtained the white and clear and definite anti-helicobacter pylori Chinese herbal medicine active compound of composition of lighter color, this anti-helicobacter pylori Chinese herbal medicine active compound purity height of while, appearance color is shallow white, so it is suitable as the medicated premix of toothpaste very much.And the made toothpaste this moment pure white exquisiteness of outward appearance not only, need not to use opaque resin, and because of anti-helicobacter pylori Chinese herbal medicine active compound purity height, the effective dose of Chinese herbal toothpaste of the present invention was guaranteed, guarantee that fully it uses effect good, has made things convenient for recipe design again and has improved the quality of products.Thereby make the present invention can obtain very reliably anti-helicobacter pylori Chinese herbal medicine active compound content height, color pure white, suppress and kill the good herbal health care toothpaste of helicobacter pylori effect in the oral cavity.
Describe realization of the present invention in detail below in conjunction with embodiment:
The specific embodiment
The Chinese herbal toothpaste that contains anti-helicobacter pylori Chinese herbal medicine active compound of the present invention comprises lotion of toothpaste substrate and supercritical CO
2Extraction anti-helicobacter pylori Chinese herbal medicine active compound, wherein said supercritical CO
2The percentage ratio that extraction anti-helicobacter pylori Chinese herbal medicine active compound accounts for the Chinese medicinal toothpaste gross weight is 0.5%～10%, and the surplus of described Chinese herbal toothpaste is a lotion of toothpaste substrate.This moment, described lotion of toothpaste substrate adopted traditional lotion of toothpaste substrate, and it includes wetting agent, binding agent, abrasive, essence and glucide and appropriate amount of deionized water, and wherein wetting agent adopts glycerol or sorbitol or propylene glycol or Polyethylene Glycol or its combination; Binding agent adopts sodium carboxymethyl cellulose or carboxyethyl cellulose or carrageenan or HANSHENGJIAO or its combination; Abrasive adopts calcium carbonate or calcium hydrogen phosphate or silicon dioxide or its combination.At this moment, the percentage ratio of described each ingredients constitute Chinese herbal toothpaste total composition weight is: wetting agent 20%～30%, binding agent 1.5%～3.5%, foaming agent 1.6%～3.0%, abrasive 40%～55%, essence 1.2%～1.8%, glucide 0.1%～0.4%, surplus are deionized water.The preferred values of the percentage ratio of each ingredients constitute Chinese herbal toothpaste total composition weight is wetting agent 18%～28%, binding agent 1.7%～3.0%, foaming agent 1.8%～2.8%, abrasive 45%～53%, essence 1.3%～1.5%, glucide 0.5%～0.3% in the wherein above-mentioned lotion of toothpaste substrate, and surplus is a deionized water.And the optimum of the percentage ratio of each ingredients constitute Chinese herbal toothpaste total composition weight is wetting agent 25%, binding agent 1.8%, foaming agent 2.7%, abrasive 50%, essence 1.3%, glucide 0.26% in the lotion of toothpaste substrate, and surplus is a deionized water.Wherein above-mentioned supercritical CO
2The percentage ratio preferred values that extraction anti-helicobacter pylori Chinese herbal medicine active compound accounts for the Chinese herbal toothpaste gross weight is 2.5%～5%.This moment supercritical CO of the present invention
2The percentage ratio optimum that extraction anti-helicobacter pylori Chinese herbal medicine active compound accounts for the Chinese herbal toothpaste gross weight is 3%.Simultaneously for to make the more remarkable treatment effect of Chinese herbal toothpaste of the present invention lasting, anti-helicobacter pylori Chinese herbal medicine active compound in the Chinese herbal toothpaste of the present invention both can be independent Herba Houttuyniae active matter or Herba Taraxaci active matter or Pericarpium Granati active matter or Herba Agrimoniae active matter, it also can be the combination of the two kinds or more of active matters in above-mentioned each active matter, thereby reach coordinating effect so that its more remarkable effect, above-mentioned supercritical CO at this moment
2Extraction anti-helicobacter pylori Chinese herbal medicine active compound is a supercritical CO
2Extraction Herba Houttuyniae active matter or supercritical CO
2Extraction Herba Taraxaci active matter or supercritical CO
2Extraction Pericarpium Granati active matter or supercritical CO
2The supercritical CO of extraction Herba Agrimoniae active matter or its at least two kinds and two or more combinations
2The extraction active compound.
This moment the supercritical CO that contains of the present invention
2The manufacture method of the Chinese herbal toothpaste of the anti-helicobacter pylori Chinese herbal medicine active compound of extraction may further comprise the steps:
(1) binding agent is joined in the wetting agent, stir and form finely dispersed suspension;
(2) glucide is joined in the deionized water, be stirred to dissolving fully;
(3) wetting agent and the described liquor saccharini of step (2) are joined the suspension described in the step 1, stir into transparent rubber cement;
(4) with oil-soluble supercritical CO
2The Herba Houttuyniae of extraction or Herba Taraxaci or Pericarpium Granati or Herba Agrimoniae or its at least two kinds and two or more active compound are dissolved in the essence;
(5) with abrasive, foaming agent and be dissolved with supercritical CO
2The essence of the Herba Houttuyniae of extraction or Herba Taraxaci or Pericarpium Granati or Herba Agrimoniae or its at least two kinds and two or more active compound active compounds joins in the above-mentioned rubber cement, stir into paste, after grinding the degassing, obtain lotion of toothpaste again, and, be packaged to be the toothpaste finished product through aseptic process.
This moment supercritical CO of the present invention
2The preparation method of extraction Herba Houttuyniae, Herba Taraxaci, Pericarpium Granati, Herba Agrimoniae isoreactivity thing is: a certain amount of Herba Houttuyniae, Pericarpium Granati, Herba Taraxaci, Herba Agrimoniae or its at least two kinds and two or more combination drying things are put in the extraction kettle, to extraction kettle, first extraction-container, second extraction-container, detached dowel heats respectively or cool off, when reaching selected temperature, open CO
2Bottle pressurizes to whole device by high-pressure pump, when extraction kettle, first extraction-container, second extraction-container, when detached dowel pressure reaches the pressure that sets respectively, close CO
2Bottle, the beginning cycling extraction adds a certain amount of entrainer simultaneously, and regulates CO
2Flow to a certain amount of, keep constant temperature and pressure.After reaching selected extraction time,, obtain desired supercritical CO from the second extraction-container discharge hole for discharge
2Extraction anti-helicobacter pylori Chinese herbal medicine active compound.
Embodiment 1:
Contain supercritical CO described in this enforcement
2The Chinese herbal toothpaste of anti-helicobacter pylori Chinese herbal medicine active compound of extraction includes that to account for the Chinese herbal toothpaste total weight percent be following constituent: glycerol 10%, and sorbitol 15%, CMC 1.7%, glucide 0.1%, K
121.8%, calcium carbonate 47%, supercritical CO
2Extraction Herba Houttuyniae active matter 10%, essence 1.0%, surplus is a deionized water.
Embodiment 2:
Contain supercritical CO described in this enforcement
2The Chinese herbal toothpaste of anti-helicobacter pylori Chinese herbal medicine active compound of extraction includes that to account for the Chinese herbal toothpaste total weight percent be following constituent: glycerol 12%, and sorbitol 17%, CMC 1.5%, and HEC 0.2%, glucide 0.13%, K
122%, calcium carbonate 47%, supercritical CO
2Extraction Herba Taraxaci active matter 10%, essence 1.2%, deionized water surplus.
Embodiment 3:
Contain supercritical CO described in this enforcement
2The Chinese herbal toothpaste of anti-helicobacter pylori Chinese herbal medicine active compound of extraction includes that to account for the Chinese herbal toothpaste total weight percent be following constituent: Polyethylene Glycol 10%, sorbitol 16%, CMC1.4%, HANSHENGJIAO 0.3%, glucide 0.5%, K
122.3%, calcium carbonate 46%, supercritical CO
2Extraction Pericarpium Granati active matter 10%, essence 1.5%, surplus is a deionized water.
Embodiment 4:
Contain supercritical CO described in this enforcement
2The Chinese herbal toothpaste of anti-helicobacter pylori Chinese herbal medicine active compound of extraction includes that to account for the Chinese medicinal toothpaste total weight percent be following constituent: Polyethylene Glycol 13%, sorbitol 18%, CMC1.1%, carrageenan 0.6%, glucide 0.28%, K
122.3%, calcium hydrogen phosphate 35%, silicon dioxide 5%, supercritical CO
2Extraction Herba Agrimoniae active matter 10%, essence 1.4%, surplus is a deionized water.
Embodiment 5:
Propylene glycol 8%, sorbitol 20%, CMC 1.1%, carrageenan 0.6 glucide 0.25%, K
122.2%, calcium hydrogen phosphate 47%, supercritical CO
2Extraction Herba Houttuyniae and Herba Taraxaci active compound 5%, essence 1.5%, deionized water surplus.
Embodiment 6:
Propylene glycol 10%, sorbitol 18%, CMC 1.4%, HANSHENGJIAO 0.3%, glucide 0.28%, K
121.5%, calcium hydrogen phosphate 40%, silicon dioxide 8%, supercritical CO
2Extraction Pericarpium Granati and Herba Agrimoniae active compound 3%, essence 1.2%, deionized water surplus.
Embodiment 7:
Sorbitol 25%, HANSHENGJIAO 1.7% glucide 0.22%, K
122.4%, calcium carbonate 43%, silicon dioxide 6%, supercritical CO
2Extraction Herba Houttuyniae and Herba Taraxaci and Pericarpium Granati active compound 2.5%, essence 1.6%, deionized water surplus.
Embodiment 8:
Sorbitol 26%, xanthan gum 1.8%, glucide 0.30%, K
121.5%, calcium carbonate 42%, silicon dioxide 7%, supercritical CO
2Extraction Herba Houttuyniae and Herba Taraxaci and Pericarpium Granati and Herba Agrimoniae active compound 0.5%, essence 1.8%, deionized water surplus.
Claims (6)
1, a kind of Chinese herbal toothpaste that contains anti-helicobacter pylori Chinese herbal medicine active compound is characterized in that described Chinese herbal toothpaste comprises lotion of toothpaste substrate and supercritical CO
2Extraction anti-helicobacter pylori Chinese herbal medicine active compound, wherein said supercritical CO
2The percentage ratio that extraction anti-helicobacter pylori Chinese herbal medicine active compound accounts for the Chinese medicinal toothpaste gross weight is 0.5%～10%, and the surplus of described Chinese medicinal toothpaste is a lotion of toothpaste substrate.
2, Chinese herbal toothpaste according to claim 1 is characterized in that above-mentioned supercritical CO
2The percentage ratio that extraction anti-helicobacter pylori Chinese herbal medicine active compound accounts for the Chinese herbal toothpaste gross weight is 2.5%～5%.
3, Chinese herbal toothpaste according to claim 2 is characterized in that above-mentioned supercritical CO
2The percentage ratio that extraction anti-helicobacter pylori Chinese herbal medicine active compound accounts for the Chinese herbal toothpaste gross weight is 3%.
4, according to claim 1 or 2 or 3 described Chinese herbal toothpastes, it is characterized in that above-mentioned supercritical CO
2Extraction anti-helicobacter pylori Chinese herbal medicine active compound is a supercritical CO
2Extraction Herba Houttuyniae active matter or supercritical CO
2Extraction Herba Taraxaci active matter or supercritical CO
2Extraction Pericarpium Granati active matter or supercritical CO
2The supercritical CO of extraction Herba Agrimoniae active matter or its at least two kinds and two or more combinations
2The extraction active compound.
5,, it is characterized in that above-mentioned lotion of toothpaste substrate comprises that accounting for the Chinese herbal toothpaste total weight percent is following constituent according to claim 1 or 2 or 3 described Chinese herbal toothpastes:
Wetting agent 20%～30% binding agent 1.5%～3.5%
Foaming agent 1.6%～3.0% abrasivus 40%～55%
Essence 1.2%～1.8% glucide 0.1%～0.4%
Surplus is a deionized water.
6, a kind ofly make the method that aforesaid right requires described Chinese herbal toothpaste, it is characterized in that may further comprise the steps:
(1) binding agent is joined in the wetting agent, stir and form finely dispersed suspension;
(2) glucide is added deionized water, be stirred to dissolving fully;
(3) liquor saccharini in wetting agent and the step (2) is joined suspension in the step (1), stir into transparent rubber cement;
(4) with the oil-soluble supercritical CO that passes through
2The Herba Houttuyniae of extraction or Herba Taraxaci or Pericarpium Granati or Herba Agrimoniae or its at least two kinds and two or more active compound are dissolved in essence;
(5) with abrasive, foaming agent and be dissolved with supercritical CO
2The essence of the Herba Houttuyniae of extraction or Herba Taraxaci or Pericarpium Granati or Herba Agrimoniae or its at least two kinds and two or more active compounds joins in the above-mentioned rubber cement, stir into paste, after grinding the degassing, obtain lotion of toothpaste again, and, be packaged to be the toothpaste finished product through aseptic process.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008100284065A CN101278893A (en) | 2008-05-30 | 2008-05-30 | Chinese herbal medicine toothpaste containing Chinese herbal medicine active combination against Helicobacter pylori and method for producing the same |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100284065A CN101278893A (en) | 2008-05-30 | 2008-05-30 | Chinese herbal medicine toothpaste containing Chinese herbal medicine active combination against Helicobacter pylori and method for producing the same |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102151241A (en) * | 2011-03-31 | 2011-08-17 | 浙江农林大学 | Toothpaste containing natural plant extractive and preparation method thereof |
| CN104739726A (en) * | 2015-03-30 | 2015-07-01 | 美晨集团股份有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN105055230A (en) * | 2015-08-11 | 2015-11-18 | 刘三猫 | Multifunctional Chinese medicinal toothpaste composition, toothpaste prepared from composition and preparation method of toothpaste |
| CN105963217A (en) * | 2016-07-09 | 2016-09-28 | 青岛大学 | Preparation method of toothpaste composition with caries prevention effect |
| CN108670931A (en) * | 2018-07-24 | 2018-10-19 | 冯绍良 | A kind of toothpaste and its production method for capableing of suppressing and killing helicobacter pylori |
| CN111616996A (en) * | 2020-05-08 | 2020-09-04 | 广东立爽生物科技有限公司 | Helicobacter pylori-resistant toothpaste and preparation method thereof |
| CN112402497A (en) * | 2020-11-03 | 2021-02-26 | 贵州慧创科技发展有限公司 | Chinese herbal medicine formula for treating animal diarrhea |
-
2008
- 2008-05-30 CN CNA2008100284065A patent/CN101278893A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102151241A (en) * | 2011-03-31 | 2011-08-17 | 浙江农林大学 | Toothpaste containing natural plant extractive and preparation method thereof |
| CN102151241B (en) * | 2011-03-31 | 2012-11-14 | 浙江农林大学 | Toothpaste containing natural plant extractive and preparation method thereof |
| CN104739726A (en) * | 2015-03-30 | 2015-07-01 | 美晨集团股份有限公司 | Traditional Chinese medicine toothpaste and preparation method thereof |
| CN104739726B (en) * | 2015-03-30 | 2017-11-21 | 美晨集团股份有限公司 | A kind of Chinese medicine toothpaste and preparation method thereof |
| CN105055230A (en) * | 2015-08-11 | 2015-11-18 | 刘三猫 | Multifunctional Chinese medicinal toothpaste composition, toothpaste prepared from composition and preparation method of toothpaste |
| CN105963217A (en) * | 2016-07-09 | 2016-09-28 | 青岛大学 | Preparation method of toothpaste composition with caries prevention effect |
| CN108670931A (en) * | 2018-07-24 | 2018-10-19 | 冯绍良 | A kind of toothpaste and its production method for capableing of suppressing and killing helicobacter pylori |
| CN111616996A (en) * | 2020-05-08 | 2020-09-04 | 广东立爽生物科技有限公司 | Helicobacter pylori-resistant toothpaste and preparation method thereof |
| CN112402497A (en) * | 2020-11-03 | 2021-02-26 | 贵州慧创科技发展有限公司 | Chinese herbal medicine formula for treating animal diarrhea |
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Application publication date: 20081008 |