CN101502482B - Toothpaste containing coenzyme Q10 and preparation method thereof - Google Patents
Toothpaste containing coenzyme Q10 and preparation method thereof Download PDFInfo
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- CN101502482B CN101502482B CN2009100942609A CN200910094260A CN101502482B CN 101502482 B CN101502482 B CN 101502482B CN 2009100942609 A CN2009100942609 A CN 2009100942609A CN 200910094260 A CN200910094260 A CN 200910094260A CN 101502482 B CN101502482 B CN 101502482B
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Abstract
The invention relates to a toothpaste containing coenzyme Q10 and a preparation method thereof, in particular to a composition of toothpastes, belonging to the field of oral healthcare products; based on weight percentage, the coenzyme Q10 in the toothpaste is 1-2% and Chinese herbal extract is 0.5-2%; the rest of accessories are conventional materials for preparing toothpastes. The formulation proportion of the components in the toothpaste is preferably as follows: 2% of coenzyme Q10 mixture, 0.7% of Chinese herbal extract, 35% of abradant, 1.5% of bonding agent, 35% of wetting agent, 0.2% of flavoring agent, 2.5% of foaming agent, 1.5% of essence and 21.6% of deionized water. The toothpaste containing coenzyme Q10 has the healthcare functions the same as the common toothpastes, such as brightening and cleaning the teeth, stopping bleeding of gums and healing oral ulcer; besides, the coenzyme Q10 and Chinese herbal extract permeate the gum cell membrane so that the gum cell obtains energy and tissue vigor is strengthened, thereby essentially conserving the gums, preventing periodontitis, gingivitis and gingival atrophy to reach the aim of strengthening the gums and fixing teeth.
Description
Technical field
The present invention relates to the compositions of a kind of toothpaste that contains coenzyme Q10 and preparation method thereof, particularly toothpaste.Belong to the oral health care product field.
Background technology
Coenzyme Q10 is that human body newly becomes the indispensable material of metabolism, is present in the human body cell " mitochondrion ", participates in energy ATP and synthesizes; Have antioxidation and cell membrane repair; Along with the growth at human body age, human body coenzyme Q10 synthesis capability descends after 20 years old, and concentration is lower than when a certain amount of; Can cause Developmental and Metabolic Disorder, bring out tooth diseases such as periodontitis, gingivitis, gingival atrophy.
Toothpaste is one of people's articles for daily use, can cleaning oral cavity tooth and antiplaque effect with it.Toothpaste in the market is of a great variety, differs from one another, and is liked and acceptance by consumers in general with its abnormal smells from the patient and effect uniqueness.Along with people's improves the understanding of health care gradually; Existing toothpaste can not satisfy the different demands of consumer far away; The most of people that particularly cause gingival hemorrhage to oral inflammation; Resistance of human body is descended, be prone to grow other diseases, functional medical toothpaste has irreplaceable effect to improving human health.
People more and more paid attention to the health and medical function of toothpaste to various products in recent years, and people grow with each passing day to interest, the demand of toothpaste with health care usefulness.
Summary of the invention
The objective of the invention is to invent a kind of health-care toothpaste that contains coenzyme Q10, particularly a kind of health-care toothpaste that contains reduced coenzyme Q 10, it has effects such as hemostasis, analgesia, detumescence, antibacterial, antiinflammatory, antioxygen, resisting fatigue, enhancing immunity; Its drug effect is wide, effective without any side effects; This health-care toothpaste can effectively be prevented and treated gingivitis, gingival hemorrhage, periodontitis; Gingival swelling and pain, health care usefulness toothpaste.
The present invention also aims to adopt coenzyme Q10; Particularly reduced coenzyme Q 10 and Chinese herbal medicine extract see through the gingival cell film; Make gingival cell obtain energy, organizational vitality strengthens, from maintenance gingiva in essence; Control periodontitis, gingivitis, gingival atrophy reach the health care purpose of being good for the gum teeth consolidating.
Zhou Yan, gingivitis, gingival atrophy reach the health care purpose of being good for the gum teeth consolidating.
The present invention contains the toothpaste of coenzyme Q10 and the purpose of method for preparing is to accomplish like this: it is characterized in that by weight percentage coenzyme Q10 is 1%-2% in the toothpaste, Chinese herbal medicine extract is 0.5%-2%, and all the other adjuvants are the conventional material of preparing toothpaste.
The prescription consumption preferably; By described percentage by weight; Coenzyme Q10 mixture shared ratio in toothpaste is 2%; The shared ratio of Chinese herbal medicine extract is 0.7%, and abrasive 35%, binding agent 1.5%, wetting agent 35%, correctives 0.2%, foaming agent 2.5%, essence 1.5%, deionized water are 21.6%..
Contained coenzyme Q10 is a reduced coenzyme Q 10, and wherein percent of reduced coenzyme Q 10 and oxidized coenzyme Q10 is 95-100%: 0-5%, and oxidized coenzyme Q10 is 2005 editions standards of Chinese Pharmacopoeia, and reduced coenzyme Q 10 is applicant's company standard; Structural formula is:
(reduced coenzyme Q 10 structural formula) (oxidized coenzyme Q10 structural formula)
In the said Chinese herbal medicine extract, hemostasis, analgesia, a detumescence type Chinese herbal medicine extract are 40%, and antibacterial, anti-inflammatory type Chinese herbal medicine extract is 30%, and antioxygen, resisting fatigue, enhancing immunity class Chinese herbal medicine extract are 30%.
Said interpolation has hemostasis, analgesia, repercussive Chinese herbal medicine extract: Folium Ginseng extracts ginsenoside (ginsenoside Rg+ginseng saponin Re >=2.25%), Radix Psammosilenes (45% alcohol extract >=40%), Rhizoma Paridis (opaque and colloid); Pull out chinaroot greenbrier (60% ethanol leachable >=15%; The preparatory saponin of potato >=0.04%), Radix Notoginseng total glucosides (ginsenoside Rg+ginsenoside Rb+ Panax Notoginseng saponin R, sum total >=5%); Preferred Radix Psammosilenes, Rhizoma Paridis, Radix Notoginseng total glucosides, more preferably Radix Psammosilenes, Radix Notoginseng total glucosides in the prescription.
Said interpolation has, and Chinese herbal medicine extract antibacterial, antiinflammatory is: Taraxacum (water containing ethanol extraction extractum); Terpinol (terpin tetraol >=3%); Herba Houttuyniae (cold-water-soluble extractum >=10%) fibrauretin (fibrauretin >=90%), preferred Taraxacum, fibrauretin, more preferably Taraxacum in the prescription.
Said interpolation has antioxygen, resisting fatigue; The Chinese herbal medicine extract of enhancing immunity is: Radix Rhodiolae (rhodioside content >=0.5%); Cordyceps militaris (L.) Link. (opaque), artificial fermentation Chinese caterpillar fungus extract (opaque), Semen Vignae Cylindricae bandit (volatile oil >=5%ml/g, Folium eucalypti globueli (Eucalyptus globulus Labill.) essence >=3%), Fructus Phyllanthi (cold-water-soluble extractum >=30%); Preferred Radix Rhodiolae, Cordyceps militaris (L.) Link., Fructus Phyllanthi, more preferably artificial fermentation Chinese caterpillar fungus extract in the prescription.
The conventional adjuvant of said toothpaste is: abrasivus 15%-35%, wetting agent 15%-35%, binding agent 0.6%-2.7%; Foaming agent 0.6%-2.7%; Correctives 0.05%-0.25%; Essence 1%-2%; Deionized water 20%-25%.
Reduced coenzyme Q 10 is mixed with Chinese herbal medicine extract; Add wetting agent and deionized water and stirring, process the deionized water suspension; Mix with abrasivus, binding agent, foaming agent, correctives again, stir, grind and vacuum outgas; Add essence at last and stir, grind and vacuum outgas, obtain lotion of toothpaste.
The abrasivus that toothpaste adds is: calcium carbonate, calcium hydrogen phosphate, silicon dioxide, aluminium hydroxide, Alumina hydrate, thermoplastic resin, preferred silicon dioxide, aluminium hydroxide, more preferably calcium hydrogen phosphate in the prescription;
The wetting agent that toothpaste adds is: sorbitol, glycerol, propylene glycol, xylitol, Polyethylene Glycol (400-600), preferably glycerine, xylitol, Polyethylene Glycol, more preferably xylitol in the prescription;
The binding agent that toothpaste adds is: extra large bath acid sodium, carboxymethyl cellulose, xanthan gum, hydroxyethyl-cellulose, guar gum, carrageenan, preferred extra large bath acid sodium, carboxymethyl cellulose, hydroxyethyl-cellulose, more preferably carboxymethyl cellulose in the prescription;
The correctives that toothpaste adds is: sucrose, glucide, cyclamate, dipeptide sodium, preferably sucrose, glucide, more preferably cyclamate in the prescription;
The essence that toothpaste adds is: peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, citrus seed oil, winter wood oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Borneolum Syntheticum; Preferred peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, Borneolum Syntheticum, more preferably Oleum Menthae Rotundifoliae, peppermint in the prescription;
The foaming agent that toothpaste adds is: sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, phenolic group sodium glutamate; Preferred N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, more preferably sodium lauryl sulphate in the prescription;
The present invention contains the toothpaste of coenzyme Q10, and general toothpaste brilliant white cleans the teeth except that having, the gingiva hemostasis, oral ulcer healing health care; Also have coenzyme Q10 and Chinese herbal medicine extract and see through the gingival cell film; Make gingival cell obtain energy, organizational vitality strengthens, from maintenance gingiva in essence; Control periodontitis, gingivitis, gingival atrophy, thus reach the purpose of being good for the gum teeth consolidating.
The specific embodiment:
The coenzyme Q10 that has gross weight 1%-2% in the toothpaste of the present invention; The Chinese herbal medicine extract that also adds the effect such as hemostasis, antiinflammatory, analgesia of 0.5%-1%; Other component also has abrasivus 30%-35%; Wetting agent 30%-35%; Binding agent 0.6%-2.7%; Foaming agent 0.6%-2.7%; Correctives 0.05%-0.25%; Essence 1%-2%; Deionized water is 20%-25%.
(reduced coenzyme Q 10 structural formula) (oxidized coenzyme Q10 structural formula)
Method for preparing is: with reduced form or oxidized coenzyme Q10 and Chinese herbal medicine extract with effects such as hemostasis, antiinflammatory, analgesia, antibacterial, antioxidation, resisting fatigue; Adding wetting agent or deionized water and stirring are processed the deionized water suspension and are mixed with abrasivus, binding agent, foaming agent, correctives, stir, grind and vacuum outgas; Add essence at last and stir, grind and vacuum outgas, obtain lotion of toothpaste.
Embodiment 1: take by weighing reduced coenzyme Q 10 200g, Chinese herbal medicine extract arasaponin 28g, Taraxacum extractum 21g, Fructus Phyllanthi extractum 21g; Add glycerol 3500g, add deionized water 2160ml again and stir into suspension, add calcium hydrogen phosphate 3500g, carboxymethyl cellulose 150g, sodium lauryl sulphate 250g; Cyclamate 20g stirring, grinding, vacuum outgas; Add Oleum Menthae Rotundifoliae 150g agitation grinding, vacuum outgas at last, get the coenzyme Q10 lotion of toothpaste, through aseptic canning; Pack 100, every 100g.
Embodiment 2: take by weighing reduced coenzyme Q 10 240g; Chinese herbal medicine extract Radix Psammosilenes 33.6g, terpin tetraol 25.2g, artificial fermentation Chinese caterpillar fungus extract 25.2g, adding Polyethylene Glycol (400) 4200g add deionized water 2592ml again and stir into suspension, add calcium carbonate 4200g, hydroxyethyl-cellulose 180g, sodium lauryl sulphate 300g; Glucide 24g stirring, grinding, vacuum outgas; Add peppermint 180g agitation grinding, vacuum outgas at last, get the coenzyme Q10 lotion of toothpaste, through aseptic canning; Pack 100, every 120g.
Embodiment 3: take by weighing reduced coenzyme Q 10 120g, Chinese herbal medicine extract Rhizoma Paridis 16.8g, fibrauretin 12.6g, Radix Rhodiolae 12.6g; Add sorbitol (400) 2100g, add deionized water 1296ml again and stir into suspension, add silicon dioxide 2100g, hydroxyethyl-cellulose 90g, sodium lauryl sulphate 150g; Glucide 12g stirring, grinding, vacuum outgas; Add lemon sesame oil 90g agitation grinding, vacuum outgas at last, get the coenzyme Q10 lotion of toothpaste, through aseptic canning; Pack 100, every 60g.
Claims (12)
1. a toothpaste that contains coenzyme Q10 is characterized in that by weight percentage, and coenzyme Q10 is 1%-2% in the toothpaste, and Chinese herbal medicine extract is 0.5%-2%, and all the other adjuvants are the conventional material of preparing toothpaste;
In the said Chinese herbal medicine extract, hemostasis, analgesia, a detumescence type Chinese herbal medicine extract are 40%, and antibacterial, anti-inflammatory type Chinese herbal medicine extract is 30%, and antioxygen, resisting fatigue, enhancing immunity class Chinese herbal medicine extract are 30%;
Said interpolation has hemostasis, analgesia, repercussive Chinese herbal medicine extract: Folium Ginseng extracts ginsenoside, Radix Psammosilenes, Rhizoma Paridis, pulls out chinaroot greenbrier, Radix Notoginseng total glucosides; Wherein said Folium Ginseng extracts the ginsenoside and is ginsenoside Rg+ ginseng saponin Re >=2.25%; Said Radix Psammosilenes is 45% alcohol extract >=40%; Said Rhizoma Paridis is opaque and colloid, and the said chinaroot greenbrier that pulls out is 60% ethanol leachable >=15%, the preparatory saponin of potato >=0.04%; Said Radix Notoginseng total glucosides is a ginsenoside Rg+ ginsenoside Rb+ Panax Notoginseng saponin R, sum total >=5%;
Said interpolation has, and Chinese herbal medicine extract antibacterial, antiinflammatory is: Herba Taraxaci, terpinol, Herba Houttuyniae, fibrauretin; Wherein said Herba Taraxaci is a water containing ethanol extraction extractum; Said terpinol is terpin tetraol >=3%; Said Herba Houttuyniae is cold-water-soluble extractum >=10%; Said fibrauretin is fibrauretin >=90%;
Said interpolation has antioxygen, resisting fatigue, and the Chinese herbal medicine extract of enhancing immunity is: Radix Rhodiolae, Cordyceps militaris (L.) Link., artificial fermentation Chinese caterpillar fungus extract, Semen Vignae Cylindricae bandit, Fructus Phyllanthi; Wherein said Radix Rhodiolae is rhodioside content >=0.5%; Said Cordyceps militaris (L.) Link. is an opaque; Said artificial fermentation Chinese caterpillar fungus extract is an opaque; Said Semen Vignae Cylindricae bandit is volatile oil >=5%ml/g, Folium eucalypti globueli (Eucalyptus globulus Labill.) essence >=3%; Said Fructus Phyllanthi is cold-water-soluble extractum >=30%.
2. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that the conventional adjuvant of said toothpaste is: abrasivus 15%-35%, wetting agent 15%-35%, binding agent 0.6%-2.7%; Foaming agent 0.6%-2.7%; Correctives 0.05%-0.25%; Essence 1%-2%; Deionized water 20%-25%, the conventional adjuvant component of coenzyme Q10, Chinese herbal medicine extract and each toothpaste sum is 100%.
3. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that it is Radix Psammosilenes, Rhizoma Paridis, Radix Notoginseng total glucosides that said interpolation has hemostasis, analgesia, repercussive Chinese herbal medicine extract.
4. the toothpaste that contains coenzyme Q10 according to claim 3 is characterized in that it is Radix Psammosilenes, Radix Notoginseng total glucosides that said interpolation has hemostasis, analgesia, repercussive Chinese herbal medicine extract.
5. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that it is Herba Taraxaci, fibrauretin that said interpolation has Chinese herbal medicine extract antibacterial, antiinflammatory.
6. the toothpaste that contains coenzyme Q10 according to claim 5 is characterized in that it is Herba Taraxaci that said interpolation has Chinese herbal medicine extract antibacterial, antiinflammatory.
7. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that said interpolation has antioxygen, resisting fatigue, and the Chinese herbal medicine extract of enhancing immunity is Radix Rhodiolae, Cordyceps militaris (L.) Link., Fructus Phyllanthi.
8. the toothpaste that contains coenzyme Q10 according to claim 1 is characterized in that said interpolation has antioxygen, resisting fatigue, and the Chinese herbal medicine extract of enhancing immunity is that artificial ferment cordyceps sinensis is smart.
9. the method for preparing that contains coenzyme Q10 toothpaste according to claim 1 and 2; It is characterized in that: reduced coenzyme Q 10 is mixed with Chinese herbal medicine extract; Add wetting agent and deionized water and stirring, process the deionized water suspension; Mix with abrasivus, binding agent, foaming agent, correctives again, stir, grind and vacuum outgas, add essence at last and stir, grind and vacuum outgas, obtain lotion of toothpaste.
10. the method for preparing that contains coenzyme Q10 toothpaste according to claim 9 is characterized in that the abrasivus that toothpaste adds is: calcium carbonate, calcium hydrogen phosphate, silicon dioxide, aluminium hydroxide, Alumina hydrate, thermoplastic resin;
The wetting agent that toothpaste adds is: sorbitol, glycerol, propylene glycol, xylitol, molecular weight are the Polyethylene Glycol of 400-600;
The binding agent that toothpaste adds is: extra large bath acid sodium, carboxymethyl cellulose, xanthan gum, hydroxyethyl-cellulose, guar gum, carrageenan;
The correctives that toothpaste adds is: sucrose, glucide, cyclamate, dipeptide sodium;
The essence that toothpaste adds is: peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, orange oil, citrus seed oil, winter wood oil, Oleum Caryophylli, Oleum Cinnamomi, Oleum Anisi Stellati, Borneolum Syntheticum;
The foaming agent that toothpaste adds is: sodium lauryl sulphate, N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate, phenolic group sodium glutamate.
11. the method for preparing that contains coenzyme Q10 toothpaste according to claim 10 is characterized in that abrasivus is silicon dioxide, aluminium hydroxide; Wetting agent is glycerol, xylitol, Polyethylene Glycol; Binding agent is extra large bath acid sodium, carboxymethyl cellulose, hydroxyethyl-cellulose; Correctives is sucrose, glucide; Essence is peppermint, lemon sesame oil, Oleum Menthae Rotundifoliae, Borneolum Syntheticum; Foaming agent is N-sodium lauroyl sarcosine, methyl cocoa ester group sodium taurocholate.
12. the method for preparing that contains coenzyme Q10 toothpaste according to claim 10 is characterized in that abrasivus is a calcium hydrogen phosphate; Wetting agent is an xylitol; Binding agent is a carboxymethyl cellulose; Correctives is a cyclamate; Essence is Oleum Menthae Rotundifoliae, peppermint; Foaming agent is a sodium lauryl sulphate.
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| CN2009100942609A CN101502482B (en) | 2009-03-27 | 2009-03-27 | Toothpaste containing coenzyme Q10 and preparation method thereof |
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| CN2009100942609A CN101502482B (en) | 2009-03-27 | 2009-03-27 | Toothpaste containing coenzyme Q10 and preparation method thereof |
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| CN101502482A CN101502482A (en) | 2009-08-12 |
| CN101502482B true CN101502482B (en) | 2012-05-30 |
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| CN102552082A (en) * | 2011-09-24 | 2012-07-11 | 云南龙润药业有限公司 | Toothpaste containing Phyllanthus emblica extracts |
| CN102961320B (en) * | 2012-11-20 | 2014-06-04 | 张伟 | Toothpaste containing extractive of Chinese caterpillar fungus and machining method thereof |
| TW201613561A (en) * | 2014-02-17 | 2016-04-16 | Kaneka Corp | Composition comprising reduced coenzyme q10 |
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| CN104522646A (en) * | 2014-12-18 | 2015-04-22 | 无限极（中国）有限公司 | Composition with functions of enhancing immunity and relieving physical fatigue and application thereof |
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| CN104666621B (en) * | 2015-02-03 | 2020-01-10 | 湖南炎帝生物工程有限公司 | A Chinese medicinal composition with hemostatic, antiinflammatory and antibacterial effects, and toothpaste containing the same |
| CN106137787B (en) * | 2015-04-10 | 2019-07-26 | 伊比西(北京)植物药物技术有限公司 | Emulsification composition of reduced coenzyme Q 10 and preparation method thereof |
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