CN103340797A - Application of centella extract in Chinese medicinal toothpaste - Google Patents
Application of centella extract in Chinese medicinal toothpaste Download PDFInfo
- Publication number
- CN103340797A CN103340797A CN2013102946117A CN201310294611A CN103340797A CN 103340797 A CN103340797 A CN 103340797A CN 2013102946117 A CN2013102946117 A CN 2013102946117A CN 201310294611 A CN201310294611 A CN 201310294611A CN 103340797 A CN103340797 A CN 103340797A
- Authority
- CN
- China
- Prior art keywords
- toothpaste
- herba centellae
- chinese medicinal
- centella
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an application of a centella extract in Chinese medicinal toothpaste and relates to the technical field of toothpaste, namely in a preparation technique of the toothpaste, the centella extract is added into the toothpaste as an ancillary drug raw material for resisting inflammation and dental ulcer. In preparation of the toothpaste provided by the invention, centella is added as a raw material of a natural plant active component, and the centella not only is safe to use and has remarkable effects for resisting inflammation and dental ulcer, but also can prevent periodontitis, gingivitis and dental ulcer and restore oral mucosa, moreover, the toothpaste adopts single drug, so the production technique is simple, the source of the traditional Chinese medicine raw materials is wider, and the cost is lower.
Description
Technical field
Technical field
The present invention relates to the toothpaste technical field, especially a kind ofly contain the application of Herba Centellae extract in Chinese medicinal toothpaste.
Background technology
Toothpaste is oral cavity cleaning and nursing product indispensable in people's daily life.Along with consumer more and more pays close attention to security of products, more and more advocate natural and safe product, interpolation can effectively prevent and treat the Chinese medicinal toothpaste of various oral disease Chinese herbal medicine, little with its toxic and side effects, characteristics such as green, environmental protection, safety height and doubly be subjected to people's favor, the consumption demand of this series products is in continuous growth on the market.
Herba Centellae is in China south, among the peoplely is usually used in treating flu, tonsillitis, infectious hepatitis, dysentery, traumatic injury, treatment pyogenic infections from tumour or sore, traumatic hemorrhage etc., usually it drunk as herbal tea.
In the modern scientific research, the Herba Centellae extract has stronger maincenter inhibition, narcotic analgesic effect; Can promote in the body important function such as the synthetic and neovascularity generation of collagen, so be conducive to wound healing; Asiaticoside composition in the Herba Centellae extract, can also influence fibroblastic ultrastructure, improve the synthetic quantity of fibroblast DNA, promote fibroblasts proliferation, and can promote the synthetic of fibroblast collagen protein and present dose-dependence.
Technically, Herba Centellae is applied to medicine, cosmetics, skin care field more at present, be 200410093223.3 as application number, patent name is the Chinese patent of " a kind of fat-reducing and weight reducing toothpaste ", and this technology is that 8 kind of plant extracts such as Folium Nelumbinis, Fructus Resina garciniae, Herba Centellae are added to the effect that reaches weight-reducing in the toothpaste.
At present, in a lot of Chinese medicinal toothpastes, also have and adopt Herba Centellae, be 02824271.8 as the patent No., patent name is the Chinese patent of " solid composition for oral cavity ", this patent also is to adopt to comprise that 10 various plants extracts such as Herba Centellae, Radix Malvae sylvestris, Melaleuca Alternifolia, Myrrha add in the oral preparations of gum formats, plays anti-calculus, dental plaque, and antiinflammatory/alleviate hyperemia, lubricated, healing of wound, antibiotic antisepsis are arranged; And for example number of patent application is 201110105310.6, patent name is the Chinese patent application of " a kind of Chinese medicine composition for the treatment of oral disease and preparation technology thereof, quality determining method ", this technology is to use watermelon crystal, Borneolum Syntheticum, Herba Centellae and Caulis Mahoniae to form pharmaceutical composition, make interior with preparation or external preparation again, be used for the treatment of aphtha of the mouth and tongue, gingival swelling and pain or hemorrhage, stomatitis, symptoms such as oral ulcer; The patent No. is 200910096067.9 for another example, patent name is the Chinese patent of " be used for killing the composition of plant extracts, its preparation method of fungus and for the preparation of the purposes of antifungal products ", this patent disclosure a kind of 6 kind of plant extractive compositions such as asiaticoside that contain, for the preparation of antifungal products, as wash and protect and dental care products etc.
Above-mentioned technology all adopts the Chinese medicine composition form, and still nobody is applied to Herba Centellae extract in the oral cavity cleaning and nursing product with the form of single medicinal material, comparatively speaking, Chinese medicine composition processing technique complexity, cost is higher.
Summary of the invention
The invention provides a kind of have obvious anti-inflammatory and anti, anti-oral ulcer effect, in advance preventing parodontitis, gingivitis, promotion oral ulcer wound healing and simple, the lower-cost Chinese medicinal toothpaste of processing technique.
In order to solve the problems of the technologies described above, the technical solution adopted in the present invention is: the application scheme of Herba Centellae extract of the present invention in Chinese medicinal toothpaste is exactly in the technology of preparation toothpaste the ancillary drug raw material of Herba Centellae extract as antiinflammatory, anti-oral ulcer effect to be added in the toothpaste.
In the technique scheme, scheme can also be more specifically: the percentage by weight of described Herba Centellae extract in total mastic of toothpaste is 0.01～0.3%.
Herba Centellae of the present invention is dicotyledon Umbelliferae Umbelliferae, dry herb or the whole herb with root of Herba Centellae Centella asiatica (L.) Urban.Nature and flavor hardship, suffering, cold are returned the liver,spleen,kidney warp.Effect with clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling is used for jaundice due to damp-heat, heatstroke diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down etc.
Extracting method is that the herb with the samphire Herba Centellae is broken into 10 orders-30 order coarse powder, extracts 3 hours with the alcohol heating reflux of 10 times of amounts, extracts 3 times, and with the extracting solution merging, concentrating under reduced pressure is dried to powder then.
The extracting method of Herba Centellae of the present invention is not limited to said method, also can adopt additive methods such as supercritical extraction, ultrasonic extraction to extract; Also can use existing commercially available Chinese medicine Herba Centellae extract.
The content of the Herba Centellae extract described in the present invention is that 100% pure extraction powder is example with active component all, but is not limited to pure extraction powder, also can be other forms such as extracting solution or extractum.When being applied to oral care product with other forms such as extracting solution, the addition in prescription should be converted to the amount of disclosed pure form of extract among the present invention.
Toothpaste of the present invention adds Herba Centellae and not only uses safety as the raw material of natural plant active component in preparation process, effect with tangible antiinflammatory, anti-oral ulcer, and toothpaste employing single medicinal material form production technology is simple, and the raw material of Chinese medicine source is wider, and cost is lower.
The specific embodiment
Below in conjunction with example, the invention will be further described, and among following each embodiment, related percentage ratio all is to calculate by weight percentage except as otherwise noted:
Toothpaste constitutive material among the embodiment 1-8 and weight percent content such as following table:
The preparation method of toothpaste among the embodiment 1 ~ 9:
Lotion of toothpaste can adopt the one-step method of conventional medicine toothpaste cream production technology processed to make: liquid material such as the pure water that input measures in temporary cylinder, sorbitol; In pre-dispersed still, drop into the calcite in powder, saccharin sodium, carboxycellulose sodium, sodium lauryl sulphate, the nipalgin that measure and mix powders such as ester sodium, carry out pre-dispersed, mixing; Open cream still vacuum pump processed and suck above-mentioned liquid material; Open scraper then, advance above-mentioned powder, drive agitator and colloid mill, treat that cream processed dropped into essence after 50 minutes, close colloid mill, agitator, scraper after 10 minutes successively, vacuum breaker stops vacuum pump, makes after the sampling detection is qualified.
?
The clinical trial part:
1, adds the antiinflammatory clinical trial of Herba Centellae extract toothpaste
1.1, sample:
Herba Centellae Chinese medicinal toothpaste (embodiment 2), the blank substrate (do not contain Herba Centellae extract, other presses embodiment 2) of toothpaste, fluocinonide cream, blank (normal saline)
1.2, method and process:
1.2.1, xylol causes the antiinflammatory action of white mice ear corridor acute inflammation swelling
Choose 60 of healthy Kunming kind ♂ white mice, be divided into 6 groups at random, 10 every group.During experiment, dimethylbenzene 0.1ml/ is all smeared only to scorching in inside and outside two sides, every group every animal auris dextra corridor, and left ear does not add to handle does self blank group.After smearing dimethylbenzene 30min, inside and outside two sides, every group every animal auris dextra corridor is evenly smeared each group respectively and is only tried matter sample 0.1g/.After being tried thing 1h, the dislocation of white mice strength vertebra is put to death, and cuts two ear corridors, is tried matter sample with normal saline flush away auris dextra corridor, cleans with dry cotton ball, gets two circle auricles with card punch at same position cutter, and it is the swelling value that auris dextra sheet weight deducts left auricle weight.
The result:
Claims (2)
1. the application of Herba Centellae extract in Chinese medicinal toothpaste namely adds the ancillary drug raw material of Herba Centellae extract as antiinflammatory, anti-oral ulcer effect in the toothpaste in the technology of preparation toothpaste.
2. the application of Herba Centellae extract according to claim 1 in Chinese medicinal toothpaste is characterized in that: the percentage by weight of described Herba Centellae extract in total mastic of toothpaste is 0.01～0.3%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102946117A CN103340797A (en) | 2013-07-15 | 2013-07-15 | Application of centella extract in Chinese medicinal toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013102946117A CN103340797A (en) | 2013-07-15 | 2013-07-15 | Application of centella extract in Chinese medicinal toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103340797A true CN103340797A (en) | 2013-10-09 |
Family
ID=49275660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013102946117A Pending CN103340797A (en) | 2013-07-15 | 2013-07-15 | Application of centella extract in Chinese medicinal toothpaste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103340797A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520049A (en) * | 2013-10-18 | 2014-01-22 | 柳州两面针股份有限公司 | Application of compound traditional Chinese medicine extracts in preparation of health care products for oral care |
| EP2889026A1 (en) * | 2013-12-24 | 2015-07-01 | Generex Pharmaceuticals, Inc. | Compositions and methods for the prevention and treatment of oral diseases |
| CN104940089A (en) * | 2015-07-15 | 2015-09-30 | 韩诚 | Chinese herb mouth wash |
| CN105726407A (en) * | 2016-03-28 | 2016-07-06 | 两面针（江苏）实业有限公司 | Tooth-bushing assembly and preparation method thereof |
| CN106539892A (en) * | 2016-11-16 | 2017-03-29 | 浙江省立同德医院 | A kind of Radix Ranunculi Ternati Chinese medicine composition and its preparation method and application |
| CN107412085A (en) * | 2017-03-30 | 2017-12-01 | 广东神石生物科技有限公司 | A kind of dendrobium candidum toothpaste and preparation method thereof |
| CN104666321B (en) * | 2015-02-02 | 2018-01-19 | 东华大学 | It is a kind of to be used to treat pad pasting of canker sore and preparation method thereof |
| CN111557877A (en) * | 2020-06-24 | 2020-08-21 | 三椒口腔健康股份有限公司 | Toothpaste containing centella extract and preparation method thereof |
| CN113768841A (en) * | 2021-10-18 | 2021-12-10 | 深圳市西马龙科技有限公司 | Special toothpaste for north |
| CN115569087A (en) * | 2022-09-23 | 2023-01-06 | 拜斯特药业(广州)有限公司 | Oral care composition and oral care product |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1599593A (en) * | 2001-11-06 | 2005-03-23 | 博费蒂·迈·麦勒有限公司 | Solid oral anti-tartar and anti-plaque compositions |
-
2013
- 2013-07-15 CN CN2013102946117A patent/CN103340797A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1599593A (en) * | 2001-11-06 | 2005-03-23 | 博费蒂·迈·麦勒有限公司 | Solid oral anti-tartar and anti-plaque compositions |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520049B (en) * | 2013-10-18 | 2016-04-06 | 柳州两面针股份有限公司 | Compound Chinese medicine extract is preparing the application in oral cavity nursing health products |
| CN103520049A (en) * | 2013-10-18 | 2014-01-22 | 柳州两面针股份有限公司 | Application of compound traditional Chinese medicine extracts in preparation of health care products for oral care |
| EP2889026A1 (en) * | 2013-12-24 | 2015-07-01 | Generex Pharmaceuticals, Inc. | Compositions and methods for the prevention and treatment of oral diseases |
| CN104666321B (en) * | 2015-02-02 | 2018-01-19 | 东华大学 | It is a kind of to be used to treat pad pasting of canker sore and preparation method thereof |
| CN104940089A (en) * | 2015-07-15 | 2015-09-30 | 韩诚 | Chinese herb mouth wash |
| CN105726407A (en) * | 2016-03-28 | 2016-07-06 | 两面针（江苏）实业有限公司 | Tooth-bushing assembly and preparation method thereof |
| CN105726407B (en) * | 2016-03-28 | 2018-06-01 | 两面针（江苏）实业有限公司 | A kind of preparation method for combination of brushing teeth |
| CN106539892B (en) * | 2016-11-16 | 2020-04-14 | 浙江省立同德医院 | Radix ranunculi ternati traditional Chinese medicine composition as well as preparation method and application thereof |
| CN106539892A (en) * | 2016-11-16 | 2017-03-29 | 浙江省立同德医院 | A kind of Radix Ranunculi Ternati Chinese medicine composition and its preparation method and application |
| CN107412085A (en) * | 2017-03-30 | 2017-12-01 | 广东神石生物科技有限公司 | A kind of dendrobium candidum toothpaste and preparation method thereof |
| CN111557877A (en) * | 2020-06-24 | 2020-08-21 | 三椒口腔健康股份有限公司 | Toothpaste containing centella extract and preparation method thereof |
| CN111557877B (en) * | 2020-06-24 | 2021-05-11 | 三椒口腔健康股份有限公司 | Toothpaste containing centella extract and preparation method thereof |
| CN113768841A (en) * | 2021-10-18 | 2021-12-10 | 深圳市西马龙科技有限公司 | Special toothpaste for north |
| CN115569087A (en) * | 2022-09-23 | 2023-01-06 | 拜斯特药业(广州)有限公司 | Oral care composition and oral care product |
| CN115569087B (en) * | 2022-09-23 | 2023-11-21 | 拜斯特药业(广州)有限公司 | Oral care composition and oral care product |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103340797A (en) | Application of centella extract in Chinese medicinal toothpaste | |
| CN104207982B (en) | Prevent Chinese medicine composition and the oral care product containing it that oral cavity is got angry | |
| KR20100116333A (en) | Manufacturing methods of using herbs medicine for skin and medicine | |
| CN102205055B (en) | Medicament for repairing skin and preparation method thereof | |
| KR20100116334A (en) | Manufacturing methods of using herbs hair restorer and hair restorer | |
| CN1931034A (en) | Beautifying, whitening and spot-eliminating beverage and its prepn | |
| CN107095822B (en) | Traditional Chinese medicine composition and preparation method and application thereof | |
| CN109276475A (en) | One kind Chinese medicinal toothpaste containing bletilla polysaccharide and preparation method thereof | |
| KR20150145992A (en) | Composition for red ginseng mask pack, the manufacturing method thereof, and the mask pack manufactured thereby | |
| CN106727014A (en) | A kind of compound of wild rattan mother-in-law tea extraction and its application | |
| CN1544036A (en) | Speckle removing and whitening traditional medicinal healthy product and its preparation | |
| CN101869542B (en) | Toner comprising pawpaw extract and lotus leaf extract and preparation method thereof | |
| CN102091008A (en) | Seaweed face applying mud | |
| CN102091007A (en) | Traditional Chinese medicine face applying mud | |
| KR20170137544A (en) | Composition for improving skin condition comprising herb extracts mixture | |
| CN104873433A (en) | Moxa skin cream and preparing method thereof | |
| KR100800359B1 (en) | A composition having depilation preventing and trichogenousness effect | |
| JP7338842B2 (en) | wrinkle-improving composition and wrinkle-improving skin cosmetic | |
| CN106580779A (en) | Chinese herbal toothpaste with macadimia nut extract as main ingredient and preparation method thereof | |
| CN104306273A (en) | Natural skin-care toner containing acer negundo extract | |
| CN104323951A (en) | Pure natural low-irritation decontamination cleansing milk and preparation method thereof | |
| CN101274051A (en) | Compound formulation of capsules for curing barrenness and preparing technique | |
| CN101336876A (en) | Skin care product with moisture-keeping function | |
| KR102108912B1 (en) | Composition for improving skin moisturizing and inflammation | |
| CN105287356A (en) | Shampoo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20131009 |