CN111557877A - Toothpaste containing centella extract and preparation method thereof - Google Patents
Toothpaste containing centella extract and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The invention belongs to the technical field of oral cleaning products, and particularly relates to a toothpaste containing a centella extract and a preparation method thereof. The invention provides a toothpaste containing centella extract, which comprises the following components in percentage by weight: 20.0-28.0% of hydrated silica, 31.0-53.0% of wetting agent, 2.0-3.0% of sodium lauryl sulfate, 1.2-3.7% of anti-inflammatory soothing agent, 1.0-1.5% of essence, 0.8-1.2% of xanthan gum, 0.2-0.5% of cocamidopropyl betaine, 0.2-0.5% of sodium saccharin, 0.2-0.5% of preservative, 0.2-0.5% of titanium dioxide, 0.1-0.3% of centella asiatica extract and 7.3-43.1% of water. The toothpaste containing the centella asiatica extract is safe, mild and non-irritant, has the effects of bacteriostasis, anti-inflammation and the like, and can effectively relieve swelling and aching of gum, relieve and resist allergy.
Description
Technical Field
The invention belongs to the technical field of oral cleaning products, and particularly relates to a toothpaste containing a centella extract and a preparation method thereof.
Background
The oral cavity is one of the ways of pathogenic microorganisms invading human body, and the temperature, humidity and food residues in the oral cavity are suitable for the growth and reproduction of microorganisms. Effective oral care maintains the oral cavity clean and prevents the occurrence of oral infections. Oral health has become one of the important indicators for the world health organization to evaluate the level of human health, and maintaining oral health is a physiological requirement of humans, and oral care is an integral part of body care. Common oral problems include: swelling and aching of gums, tooth decay, canker sores, bleeding gums, gingivitis, periodontitis, gingival atrophy, and loss of cementum, among others. The health of teeth is very important to the overall health of a human. Poor oral health has been reported to be closely related to systemic diseases such as heart disease, diabetes and some respiratory diseases.
The toothpaste matrix mainly comprises one or more of glycerol, sorbitol, propylene glycol or polyethylene glycol used as a wetting agent, sodium hydroxymethyl cellulose, hydroxyethyl cellulose, carrageenan or xanthan gum used as an adhesive singly or in combination, sodium lauryl sulfate used as a surfactant, calcium carbonate, aluminum hydroxide, silicon dioxide or calcium bicarbonate used as a friction agent singly or in combination, essence and deionized water. Sodium lauryl sulfate is an excellent anionic surfactant, is used as a most common foaming agent in toothpaste, is one of important raw materials for toothpaste production, and endows the toothpaste with good foaming capacity and also plays roles in emulsification, cleaning and decontamination.
However, sodium lauryl sulfate has some irritation to the oral cavity, and in order to reduce irritation, the skilled person will generally reduce the amount of sodium lauryl sulfate or choose not to use sodium lauryl sulfate, or to use a milder foaming agent (such as sodium lauroyl sarcosinate) to reduce irritation to the oral cavity. In recent years, with the increasing living standard of the public, the requirement of people for health is improved, and toothpaste which is safe, effective and has small side effect is favored by more and more consumers.
The plant extract is a substance which exists in a plant body and is extracted by a physical or chemical method to have biological activity, and effective components of the substance, such as alkaloid, volatile oil, flavone, polysaccharide, organic acid, tannin, grease and the like, have antibacterial and anti-inflammatory effects with different degrees. Chinese patent CN 107184473B discloses a toothpaste containing spina gleditsiae extract, comprising the following components: 0.5-8 parts of spina gleditsiae extract; 10-30 parts of a wetting agent; 15-45 parts of a friction agent; 0.5-1.5 parts of foaming agent; 0.4-1.6 parts of a binder; 0.15-0.3 part of a stabilizer; 0.2-0.8 part of sweetening agent. The invention adds the natural plant extract components such as the spina gleditsiae extract and the like, has obvious effects of resisting bacteria, diminishing inflammation and the like, but the added foaming agent contains sodium lauryl sulfate, has certain irritation to the oral cavity, has poor stability, and is easy to generate the phenomena of layering and the like.
Therefore, there is a need to develop a toothpaste containing natural plant extracts, which has the basic functions of toothpaste, and also has the functions of bacteriostasis, anti-inflammation, anti-allergy, hemostasis and the like. Meanwhile, the oral liquid has the characteristics of safety, mildness, no stimulation to the oral cavity, high stability and the like.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide a toothpaste containing a centella extract and a preparation method thereof. The toothpaste containing the centella asiatica extract is safe, mild and non-irritant, has the effects of bacteriostasis, anti-inflammation and the like, and can effectively relieve swelling and aching of gum, relieve and resist allergy.
The technical scheme of the invention is as follows:
a toothpaste containing centella extract comprises the following components by weight percent:
20.0-28.0% of hydrated silica, 31.0-53.0% of wetting agent, 2.0-3.0% of sodium lauryl sulfate, 1.2-3.7% of anti-inflammatory soothing agent, 1.0-1.5% of essence, 0.8-1.2% of xanthan gum, 0.2-0.5% of cocamidopropyl betaine, 0.2-0.5% of sodium saccharin, 0.2-0.5% of preservative, 0.2-0.5% of titanium dioxide, 0.1-0.3% of centella asiatica extract and 7.3-43.1% of water.
Furthermore, the toothpaste containing the centella asiatica extract comprises the following components in percentage by weight: 22.0% of hydrated silica, 46.0% of wetting agent, 2.5% of sodium lauryl sulfate, 3.0% of anti-inflammatory soothing agent, 1.2% of essence, 1.0% of xanthan gum, 0.4% of cocamidopropyl betaine, 0.3% of sodium saccharin, 0.3% of preservative, 0.4% of titanium dioxide, 0.2% of centella extract and 22.7% of water.
Further, the wetting agent is composed of glycerol, sorbitol and polyethylene glycol-8 according to a weight ratio of 15-25: 1-3.
Further, the humectant is composed of glycerin, sorbitol, and polyethylene glycol-8 at a weight ratio of 20:21: 2.
Further, the anti-inflammatory soothing agent is composed of hyaluronic acid, potassium nitrate and zinc citrate according to the weight ratio of 1-2: 10-30: 1-5.
Furthermore, the anti-inflammatory soothing agent is composed of hyaluronic acid, potassium nitrate and zinc citrate according to the weight ratio of 1.5:20: 3.5.
Further, the preservative is sodium benzoate.
Further, the preparation method of the centella asiatica extract comprises the following steps:
crushing centella, adding deionized water with the volume 4-8 times that of the centella, soaking for 6-18 hours, heating and boiling for 1-3 hours, separating liquid medicine, adding deionized water with the volume 2-6 times that of medicine residues into the medicine residues, continuously heating and boiling for 1-3 hours, combining the liquid medicines after two times of boiling, filtering, centrifuging, discarding precipitates, concentrating supernate, drying or freeze-drying to obtain the centella extract.
In addition, the invention also provides a preparation method of the toothpaste containing the centella extract, which comprises the following steps:
s1, adding the anti-inflammatory soothing agent, the saccharin sodium and the centella asiatica extract into water, and stirring until the components are completely dissolved to obtain a mixed solution A for later use;
s2, adding xanthan gum and titanium dioxide into the wetting agent, and stirring until complete dissolution and dispersion are achieved to obtain a mixed solution B for later use;
s3, adding the mixed solution B into the mixed solution A, stirring uniformly, adding hydrated silica, adding sodium lauryl sulfate, cocamidopropyl betaine, essence and preservative, stirring uniformly to obtain paste, pumping, and packaging.
Further, the vacuum degree during stirring in the step S3 is-0.082-0.10 Mpa, the stirring temperature is 38-42 ℃, and the stirring speed is 120-180 r/min.
The added centella extract in the invention is extracted from centella. Centella asiatica is a plant of centella asiatica of Umbelliferae, and its leaves are exactly like horseshoe or half of copper coin, so it is also called as horseshoe herb, Glechomae, etc., and it is also called as Pepper mint, liverwort, etc. in folk. According to records in compendium of materia medica, centella asiatica is bitter and pungent in taste, cold in nature, non-toxic, and belongs to liver, spleen, kidney and stomach channels, and has the effects of relieving swelling and pain, clearing heat and removing toxicity, promoting urination and the like. In addition, activating blood circulation to dissipate blood stasis is one of the important efficacies of the asiatic pennywort herb, and has obvious treatment effect on congestion, swelling and pain and joint redness and swelling of human beings. The chemical components of centella asiatica mainly comprise triterpenes, flavonoids, polyacetylenes, volatile oils and the like. Modern medical research shows that the asiaticoside has obvious physiological activity and may be used in treating depression, skin wound, gastric ulcer, infectious hepatitis, dermatosis, epidemic cerebrospinal meningitis, etc. Centella asiatica extracts have long exhibited a broad spectrum of biological activities, most importantly antioxidant, anti-inflammatory, antibacterial and anticancer activities. Centella asiatica extract stimulates fibroblast proliferation and activates SMAD signaling pathways, thus increasing collagen type I production and reducing the formation of stretch marks and inflammatory responses. Terpenoids in centella asiatica extract can significantly increase the content of collagen and cell layer fibronectin (fibronectin is widely involved in cell migration, adhesion, proliferation, hemostasis, skin tissue repair, etc.), and can stimulate the production of type I collagen which promotes scar maturation and reduce the generation of inflammatory response.
Meanwhile, the anti-inflammatory soothing agent which is added in the invention and consists of hyaluronic acid, potassium nitrate and zinc citrate according to a certain proportion has obvious anti-inflammatory and soothing effects, can effectively relieve the stimulation to the oral cavity brought by sodium lauryl sulfate, and simultaneously is matched with the added centella asiatica extract for use, shows obvious synergistic effect on redness and swelling of gum and analgesia, and can relieve redness, swelling and pain of gum.
The wetting agent which is added in the invention and consists of glycerol, sorbitol and polyethylene glycol-8 according to a certain proportion is emulsified by sodium lauryl sulfate which is a surfactant and then stably exists in a colloid system. The inventor unexpectedly finds that after a certain amount of polyethylene glycol-8 is added into the wetting agent, the sodium lauryl sulfate and the wetting agent can generate a certain adsorption emulsification effect, and simultaneously, the sodium lauryl sulfate and the added xanthan gum have a synergistic effect, so that the components in the toothpaste are more stable, the solid-liquid separation phenomenon is not easy to occur, and the problems that the toothpaste is easy to generate water, coarse and dull in appearance and the like in the storage process are effectively solved.
Compared with the prior art, the toothpaste containing the centella asiatica extract provided by the invention has the following advantages:
(1) the toothpaste containing the centella extract provided by the invention has the effects of resisting inflammation and relieving redness and swelling and pain of gum. The added anti-allergy soothing agent and the centella asiatica extract have the main effects of relieving swelling and pain, and can effectively relieve swelling and pain of gum, relieve and resist allergy.
(2) The toothpaste containing the centella asiatica extract provided by the invention is safe, mild, non-irritant and high in stability, and effectively solves the problems that the toothpaste is easy to produce water and is coarse, the appearance of the toothpaste is dull and the like in the storage process.
Detailed Description
The present invention is further illustrated by the following description of specific embodiments, which are not intended to limit the invention, and various modifications and improvements can be made by those skilled in the art based on the basic idea of the invention, but the invention is within the protection scope of the invention.
Wherein, the reagents used in the invention are all common reagents and can be purchased from common reagent production and sale companies.
Example 1A toothpaste containing centella asiatica extract
The toothpaste containing the centella extract comprises the following components in percentage by weight: 20.0% of hydrated silica, 31.0% of wetting agent, 2.0% of sodium lauryl sulfate, 1.2% of anti-inflammatory soothing agent, 1.0% of essence, 0.8% of xanthan gum, 0.2% of cocamidopropyl betaine, 0.2% of saccharin sodium, 0.2% of sodium benzoate, 0.2% of titanium dioxide, 0.1% of centella extract and 43.1% of water.
The humectant consists of glycerin, sorbitol and polyethylene glycol-8 according to a weight ratio of 15:25: 3.
The anti-inflammatory soothing agent consists of hyaluronic acid, potassium nitrate and zinc citrate according to the weight ratio of 1:30: 5.
The preparation method of the centella asiatica extract comprises the following steps:
pulverizing herba Centellae, adding deionized water 4 times the volume of herba Centellae, soaking for 6 hr, heating and boiling for 1 hr, separating to obtain medicinal liquid, adding deionized water 2 times the volume of the residue into the residue, heating and boiling for 1 hr, mixing the two boiled medicinal liquids, filtering, centrifuging, discarding precipitate, concentrating the supernatant, and oven drying or lyophilizing to obtain herba Centellae extract.
The preparation method of the toothpaste containing the centella extract comprises the following steps:
s1, adding the anti-inflammatory soothing agent, the saccharin sodium and the centella asiatica extract into water, and stirring until the components are completely dissolved to obtain a mixed solution A for later use;
s2, adding xanthan gum and titanium dioxide into the wetting agent, and stirring until complete dissolution and dispersion are achieved to obtain a mixed solution B for later use;
s3, adding the mixed solution B into the mixed solution A, stirring uniformly, adding hydrated silica, adding sodium lauryl sulfate, cocamidopropyl betaine, essence and sodium benzoate, stirring uniformly to obtain paste, pumping, and packaging.
The vacuum degree during stirring in the step S3 is-0.082 Mpa, the stirring temperature is 38 ℃, and the stirring speed is 120 r/min.
Example 2A toothpaste containing centella asiatica extract
The toothpaste containing the centella extract comprises the following components in percentage by weight: 22.0% of hydrated silica, 46.0% of wetting agent, 2.5% of sodium lauryl sulfate, 3.0% of anti-inflammatory soothing agent, 1.2% of essence, 1.0% of xanthan gum, 0.4% of cocamidopropyl betaine, 0.3% of saccharin sodium, 0.3% of sodium benzoate, 0.4% of titanium dioxide, 0.2% of centella extract and 22.7% of water.
The humectant consists of glycerin, sorbitol and polyethylene glycol-8 in a weight ratio of 20:21: 2.
The anti-inflammatory soothing agent consists of hyaluronic acid, potassium nitrate and zinc citrate according to the weight ratio of 1.5:20: 3.5.
The preparation method of the centella asiatica extract comprises the following steps:
pulverizing herba Centellae, adding deionized water 6 times the volume of herba Centellae, soaking for 12 hr, heating and boiling for 2 hr, separating to obtain medicinal liquid, adding deionized water 4 times the volume of the residue into the residue, heating and boiling for 2 hr, mixing the two boiled medicinal liquids, filtering, centrifuging, discarding precipitate, concentrating the supernatant, and oven drying or lyophilizing to obtain herba Centellae extract.
The preparation method of the toothpaste containing the centella extract comprises the following steps:
s1, adding the anti-inflammatory soothing agent, the saccharin sodium and the centella asiatica extract into water, and stirring until the components are completely dissolved to obtain a mixed solution A for later use;
s2, adding xanthan gum and titanium dioxide into the wetting agent, and stirring until complete dissolution and dispersion are achieved to obtain a mixed solution B for later use;
s3, adding the mixed solution B into the mixed solution A, stirring uniformly, adding hydrated silica, adding sodium lauryl sulfate, cocamidopropyl betaine, essence and sodium benzoate, stirring uniformly to obtain paste, pumping, and packaging.
The vacuum degree during stirring in the step S3 is-0.05 Mpa, the stirring temperature is 40 ℃, and the stirring speed is 150 r/min.
Example 3A toothpaste containing centella asiatica extract
The toothpaste containing the centella extract comprises the following components in percentage by weight: 28.0 percent of hydrated silica, 53.0 percent of wetting agent, 3.0 percent of sodium lauryl sulfate, 3.7 percent of anti-inflammatory soothing agent, 1.5 percent of essence, 1.2 percent of xanthan gum, 0.5 percent of cocamidopropyl betaine, 0.5 percent of saccharin sodium, 0.5 percent of sodium benzoate, 0.5 percent of titanium dioxide, 0.3 percent of centella extract and 7.3 percent of water.
The humectant consists of glycerin, sorbitol and polyethylene glycol-8 according to a weight ratio of 25:15: 1.
The anti-inflammatory soothing agent consists of hyaluronic acid, potassium nitrate and zinc citrate according to the weight ratio of 2:10: 1.
The preparation method of the centella asiatica extract comprises the following steps:
pulverizing herba Centellae, adding deionized water 8 times the volume of herba Centellae, soaking for 18 hr, heating and boiling for 3 hr, separating to obtain medicinal liquid, adding deionized water 6 times the volume of residue into residue, heating and boiling for 3 hr, mixing the two boiled medicinal liquids, filtering, centrifuging, discarding precipitate, concentrating the supernatant, and oven drying or lyophilizing to obtain herba Centellae extract.
The preparation method of the toothpaste containing the centella extract comprises the following steps:
s1, adding the anti-inflammatory soothing agent, the saccharin sodium and the centella asiatica extract into water, and stirring until the components are completely dissolved to obtain a mixed solution A for later use;
s2, adding xanthan gum and titanium dioxide into the wetting agent, and stirring until complete dissolution and dispersion are achieved to obtain a mixed solution B for later use;
s3, adding the mixed solution B into the mixed solution A, stirring uniformly, adding hydrated silica, adding sodium lauryl sulfate, cocamidopropyl betaine, essence and sodium benzoate, stirring uniformly to obtain paste, pumping, and packaging.
The vacuum degree during stirring in the step S3 is 0.10Mpa, the stirring temperature is 42 ℃, and the stirring speed is 180 r/min.
Comparative example 1A toothpaste containing centella asiatica extract
The toothpaste containing the centella extract comprises the following components in percentage by weight: 22.0% of hydrated silica, 46.0% of wetting agent, 2.5% of sodium lauryl sulfate, 3.0% of anti-inflammatory soothing agent, 1.2% of essence, 1.0% of xanthan gum, 0.4% of cocamidopropyl betaine, 0.3% of saccharin sodium, 0.3% of sodium benzoate, 0.4% of titanium dioxide, 0.2% of centella extract and 22.7% of water.
The humectant consists of glycerin, sorbitol and polyethylene glycol-8 in a weight ratio of 20:21: 2.
The anti-inflammatory soothing agent consists of potassium nitrate and zinc citrate according to the weight ratio of 20: 3.5.
The preparation method of the centella asiatica extract is similar to that of example 2.
The preparation method of the toothpaste containing the centella asiatica extract is similar to that of example 2.
The difference from example 2 is that hyaluronic acid is not added to the anti-inflammatory soothing agent.
Comparative example 2A toothpaste containing centella asiatica extract
The toothpaste containing the centella extract comprises the following components in percentage by weight: 22.0% of hydrated silica, 46.0% of wetting agent, 2.5% of sodium lauryl sulfate, 3.0% of anti-inflammatory soothing agent, 1.2% of essence, 1.0% of xanthan gum, 0.4% of cocamidopropyl betaine, 0.3% of saccharin sodium, 0.3% of sodium benzoate, 0.4% of titanium dioxide, 0.2% of centella extract and 22.7% of water.
The humectant consists of glycerin, sorbitol and polyethylene glycol-8 in a weight ratio of 20:21: 2.
The anti-inflammatory soothing agent consists of hyaluronic acid and potassium nitrate according to the weight ratio of 1.5: 20.
The preparation method of the centella asiatica extract is similar to that of example 2.
The preparation method of the toothpaste containing the centella asiatica extract is similar to that of example 2.
The difference from example 2 is that zinc citrate is not added to the anti-inflammatory soothing agent.
Comparative example 3A toothpaste containing centella asiatica extract
The toothpaste containing the centella extract comprises the following components in percentage by weight: 22.0% of hydrated silica, 46.0% of wetting agent, 2.5% of sodium lauryl sulfate, 3.0% of anti-inflammatory soothing agent, 1.2% of essence, 1.0% of xanthan gum, 0.4% of cocamidopropyl betaine, 0.3% of saccharin sodium, 0.3% of sodium benzoate, 0.4% of titanium dioxide, 0.2% of centella extract and 22.7% of water.
The humectant consists of glycerin, sorbitol and polyethylene glycol-8 in a weight ratio of 20:21: 2.
The anti-inflammatory soothing agent consists of hyaluronic acid, potassium nitrate and zinc citrate according to the weight ratio of 1:1: 1.
The preparation method of the centella asiatica extract is similar to that of example 2.
The preparation method of the toothpaste containing the centella asiatica extract is similar to that of example 2.
The difference from the embodiment 2 is that the anti-inflammatory soothing agent consists of hyaluronic acid, potassium nitrate and zinc citrate according to the weight ratio of 1:1: 1.
Comparative example 4A toothpaste containing centella asiatica extract
The toothpaste containing the centella extract comprises the following components in percentage by weight: 22.0% of hydrated silica, 46.0% of wetting agent, 2.5% of sodium lauryl sulfate, 3.0% of anti-inflammatory soothing agent, 1.2% of essence, 1.0% of xanthan gum, 0.4% of cocamidopropyl betaine, 0.3% of saccharin sodium, 0.3% of sodium benzoate, 0.4% of titanium dioxide, 0.2% of centella extract and 22.7% of water.
The humectant consists of glycerin and sorbitol according to a weight ratio of 20: 21.
The anti-inflammatory soothing agent consists of hyaluronic acid, potassium nitrate and zinc citrate according to the weight ratio of 1.5:20: 3.5.
The preparation method of the centella asiatica extract is similar to that of example 2.
The preparation method of the toothpaste containing the centella asiatica extract is similar to that of example 2.
The difference from example 2 is that polyethylene glycol-8 is not added to the wetting agent.
Test example I, anti-inflammatory Effect test study
1. Test materials: examples 1-3, comparative examples 1-4 toothpaste containing centella asiatica extract was prepared.
2. The test method comprises the following steps: after the mice are adaptively fed for 3 days, the mice are randomly divided into 8 groups according to sex and weight
Examples 1-3, comparative examples 1-4, and blank control, 10 mice per group were depilated with sodium sulfide as an abdominal depilatory for preinitiation mice, and the toothpaste containing centella asiatica extract prepared in examples 1-3 and comparative examples 1-4 was applied to an area of 2cm × 1cm (about 10% of the total body surface area) and used in an amount of 0.5g/cm2The toothpaste to be tested is respectively and uniformly coated on the shaving area 1 time a day by locally coating a glass rod; smearing toothpaste matrix on blank control group; after the last administration for 1h, coating 0.02 ml/mouse of 100% dimethylbenzene on the front and back two faces of the left ear of a mouse, separating 4 hours, dislocating and killing the cervical vertebra of the mouse, cutting two ears along the base line of auricle, weighing by an electronic balance, and calculating swelling degree, wherein the formula is as follows: swelling degree is the weight of left ear piece to right ear piece.
3. Test results
The test results are shown in table 1.
TABLE 1 Effect on swelling of mouse ears causing inflammation
| Group of | Number of animals | Swelling degree (mg) |
| EXAMPLE 1 group | 10 | 14.7±5.02* |
| EXAMPLE 2 group | 10 | 14.1±4.79** |
| EXAMPLE 3 group | 10 | 15.2±4.36 |
| Comparative example 1 group | 10 | 22.9±2.98* |
| Comparative example 2 group | 10 | 23.4±6.71 |
| Comparative example 3 group | 10 | 21.2±5.26** |
| Comparative example 4 group | 10 | 16.3±2.64* |
| Blank control group | 10 | 26.3±4.75 |
As can be seen from Table 1: the toothpastes containing centella asiatica extracts prepared in example 1, example 2 and example 3 significantly reduced swelling degree of mouse ear pinna due to xylene and had anti-inflammatory effect, compared to the blank control group, wherein the group of example 2 was the best example of the present invention. While the toothpaste containing centella asiatica prepared in comparative examples 1-3 (when the anti-allergy soothing agent added in the present invention was changed) was significantly less effective in reducing the swelling degree of mouse ear swelling caused by xylene than the results of the experiments in examples 1-3. It can be seen that the anti-allergy soothing agent provided by the invention has the advantages of no component, obvious synergistic effect with the centella asiatica extract, good anti-inflammatory effect and capability of relieving swelling and pain of gum.
Test example two, stability test
1. Test materials: examples 1-3, comparative examples 1-4 toothpaste containing centella asiatica extract was prepared.
2. The test method comprises the following steps: toothpaste packs containing centella asiatica extracts prepared in examples 1 to 3 and comparative examples 1 to 4
Placing into a toothpaste tube for storage, storing at 5 deg.C and 40 deg.C for three months, and observing each tooth
Storage of the paste.
3. Test results
The test results are shown in table 2.
Table 2 stability test results for each toothpaste
As can be seen from Table 2: after the toothpaste containing the centella asiatica extract prepared in the groups 1-3 is stored at 5 ℃, room temperature and 40 ℃ for three months respectively, the toothpaste body is uniform and fine, and the solid-liquid separation phenomenon does not occur, which shows that the toothpaste containing the centella asiatica extract prepared by the invention has good stability. In the comparative example 4, the toothpaste cannot be stably stored after the components in the humectant are changed, and the phenomena of layering, separation and water diversion of the paste body and the like can occur after the toothpaste is placed for a certain time.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. The toothpaste containing the centella asiatica extract is characterized by comprising the following components in percentage by weight: 20.0-28.0% of hydrated silica, 31.0-53.0% of wetting agent, 2.0-3.0% of sodium lauryl sulfate, 1.2-3.7% of anti-inflammatory soothing agent, 1.0-1.5% of essence, 0.8-1.2% of xanthan gum, 0.2-0.5% of cocamidopropyl betaine, 0.2-0.5% of sodium saccharin, 0.2-0.5% of preservative, 0.2-0.5% of titanium dioxide, 0.1-0.3% of centella asiatica extract and 7.3-43.1% of water.
2. The toothpaste of claim 1, comprising centella asiatica extract, which comprises the following components in percentage by weight: 22.0% of hydrated silica, 46.0% of wetting agent, 2.5% of sodium lauryl sulfate, 3.0% of anti-inflammatory soothing agent, 1.2% of essence, 1.0% of xanthan gum, 0.4% of cocamidopropyl betaine, 0.3% of sodium saccharin, 0.3% of preservative, 0.4% of titanium dioxide, 0.2% of centella extract and 22.7% of water.
3. The toothpaste containing centella asiatica extract according to claim 1 or 2, wherein the humectant comprises glycerin, sorbitol, and polyethylene glycol-8 at a weight ratio of 15-25: 1-3.
4. The toothpaste of claim 3, wherein said humectant consists of glycerin, sorbitol, polyethylene glycol-8 in a weight ratio of 20:21: 2.
5. The toothpaste containing centella asiatica extract according to claim 1 or 2, wherein the anti-inflammatory soothing agent comprises hyaluronic acid, potassium nitrate and zinc citrate at a weight ratio of 1-2: 10-30: 1-5.
6. The toothpaste of claim 5, wherein said anti-inflammatory soothing agent comprises hyaluronic acid, potassium nitrate, and zinc citrate in a weight ratio of 1.5:20: 3.5.
7. The toothpaste containing centella asiatica extract according to claim 1 or 2, wherein said preservative is sodium benzoate.
8. The toothpaste containing centella asiatica extract according to claim 1 or 2, wherein the centella asiatica extract is prepared by the following method:
crushing centella, adding deionized water with the volume 4-8 times that of the centella, soaking for 6-18 hours, heating and boiling for 1-3 hours, separating liquid medicine, adding deionized water with the volume 2-6 times that of medicine residues into the medicine residues, continuously heating and boiling for 1-3 hours, combining the liquid medicines after two times of boiling, filtering, centrifuging, discarding precipitates, concentrating supernate, drying or freeze-drying to obtain the centella extract.
9. A process for the preparation of a toothpaste containing an extract of centella asiatica according to any one of claims 1 to 8, comprising the following steps:
s1, adding the anti-inflammatory soothing agent, the saccharin sodium and the centella asiatica extract into water, and stirring until the components are completely dissolved to obtain a mixed solution A for later use;
s2, adding xanthan gum and titanium dioxide into the wetting agent, and stirring until complete dissolution and dispersion are achieved to obtain a mixed solution B for later use;
s3, adding the mixed solution B into the mixed solution A, stirring uniformly, adding hydrated silica, adding sodium lauryl sulfate, cocamidopropyl betaine, essence and preservative, stirring uniformly to obtain paste, pumping, and packaging.
10. The method of claim 9, wherein the stirring in step S3 is performed under a vacuum of-0.082-0.10 MPa, at a temperature of 38-42 ℃, and at a speed of 120-180 rpm.
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