CN107469038A - A kind of emulsifiable paste for treating tinea pedis and preparation method thereof - Google Patents
A kind of emulsifiable paste for treating tinea pedis and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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Abstract
The invention provides a kind of emulsifiable paste for treating tinea pedis and preparation method thereof, contains following material：Eucalyptus oil, aloe, hippophae rhamnoides fruit oil, linseed oil, general-purpose self-emulsifying mixed emulsifier AC 402, all-round emulsifying agent, distilled water, common fig leaf juice extract solution, Chinese anise extract solution, frutus cnidii extract solution, spina gleditsiae extract solution, willow leaf extract solution, leek extracts, pine needle extract, Folium Artemisiae Argyi extractive liquid, Pericarpium Zanthoxyli extract, pepper extract solution, garlic extract, rhizoma zingiberis extract solution, light-coloured vinegar, methyl-silicone oil, sodium carboxymethylcellulose, miconazole nitrate, methyl hydroxybenzoate and essence.Compared with prior art, the present invention is easy to use, adds natural Chinese medicinal herb extract component, gentle non-stimulated, can treat pruitus, dermatitis, fungi, mitigate congestion of blood vessel degree, mitigate local pain, while effectively treating tinea pedis, safety is without hidden danger.
Description
Technical field
The present invention relates to field of medicaments, more particularly to a kind of emulsifiable paste for treating tinea pedis and preparation method thereof.
Background technology
Tinea pedis refers to the skin disease for causing pedal skin to damage by fungal infection.The skin lesion of tinea pedis has a feature, i.e.,
Clear border, it can may occur in which erosion, sepage gradually to external expansion, and because disease development or Sao are grabbed, bacterium infection, occur useless fellow
Deng having had a strong impact on the quality of life and health of people.
And mainly there are partial smearing antifungal, oral medication and Chinese herbal medicine pedicure three to the processing method of tinea pedis at present
Kind.But the antifungal sold on the market at present is more based on chemical raw material, and human body skin is injured greatly, and high recurrence rate；
Although oral medication effect is good, many side reactions can be brought, easily body is caused damage；Using some methods among the people or in
Herbal medicine bubble pin to boil water, cycle length, curative effect is not good enough, and is inconvenient to use.And the compound preparation for using pure natural Chinese herbal medicine to prepare is
Generally acknowledged the most safely and effectively treats one of tinea pedis method, is also praised highly by dermatologist.
Therefore it provides a kind of emulsifiable paste of safe and efficient treatment tinea pedis, can not only make up existing treatment tinea pedis method
Weak point, more preferable anti-bacterial, anti-itching effect is can be simultaneously reached, people is no longer perplexed by tinea pedis.
The content of the invention
It is an object of the invention to provide a kind of emulsifiable paste for treating tinea pedis, containing natural component extract, has more preferable
Anti-bacterial, anti-itching effect.
Another object of the present invention is to provide a kind of preparation method for the emulsifiable paste for treating tinea pedis.
A kind of emulsifiable paste for treating tinea pedis provided by the invention, the raw material containing following proportioning：
Described common fig leaf juice extract solution is prepared by the following method：
It is appropriate to weigh fresh fig leaf, shreds, heating and refluxing extraction 3 times：1st time plus 18-22 times measure water, extract 1.0-
1.5h；2nd time plus 16-20 times measure water, extract 1.0-1.5h；3rd time plus 12-16 times measure water, extract 0.5-1.0h；Filtration every time
Filtrate, merging filtrate are obtained, the volume concentration of filtrate is filtered and produced to 3-5 times of g/mL of common fig leaf juice weight.
Described Chinese anise extract solution is prepared by the following method：
It is appropriate to weigh Chinese anise coarse powder, 80% ethanol immersion 0.3-0.6h, heating and refluxing extraction 3 times：1st time plus 12-
16 times of 80% ethanol of amount, extract 1.5-2.0h；2nd time plus 10-12 times measure 80% ethanol, extract 1.0-1.5h；3rd time plus 8-10
80% ethanol of amount again, extract 0.5-1.0h；Filtrate, merging filtrate are filtered to obtain every time, and volume concentration to the Chinese anise of filtrate weighs
3-8 times of g/mL of amount, filters and produces.
Described frutus cnidii extract solution is prepared by the following method：
It is appropriate to weigh frutus cnidii, 75% ethanol immersion 0.4-0.8h, heating and refluxing extraction 3 times：1st time plus 16-20 times are measured
75% ethanol, extract 1.5-2.0h；2nd time plus 14-16 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 8-12 times are measured
75% ethanol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, the 4-6 of the volume concentration of filtrate to frutus cnidii weight
Times g/mL, filters and produces.
Described spina gleditsiae extract solution is prepared by the following method：
It is appropriate to weigh spina gleditsiae coarse powder, 70% ethanol immersion 0.5-1.0h, heating and refluxing extraction 3 times：1st time plus 14-18
70% ethanol of amount again, extract 1.0-1.5h；2nd time plus 12-14 times measure 70% ethanol, extract 0.5-1.0h；3rd time plus 8-12 times
70% ethanol is measured, extracts 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, the volume concentration of filtrate to spina gleditsiae weight
4-8 times of g/mL, filters and produces.
Described willow leaf extract solution is prepared by the following method：
It is appropriate to weigh fresh willow leaf, shreds, heating and refluxing extraction 3 times：1st time plus 14-16 times measure water, extract 1.5-
2.0h；2nd time plus 10-12 times measure water, extract 1.0-1.5h；3rd time plus 8-10 times measure water, extract 0.5-1.0h；Filtration every time
Filtrate, merging filtrate are obtained, the volume concentration of filtrate is filtered and produced to 3-6 times of g/mL of willow leaf weight.
Described leek extracts are prepared by the following method：
It is appropriate to weigh leek, shreds, heating decocts extraction 3 times：1st time plus 10-14 times measure water, extract 1.5-2.0h；2nd
It is secondary to add 10-14 times to measure water, extract 1.5-2.0h；3rd time plus 8-12 times measure water, extract 0.5-1.0h；Filtrate is filtered to obtain every time, is closed
And filtrate, the volume concentration of filtrate are filtered and produced to 4-8 times of g/mL of leek weight.
Described pine needle extract is prepared by the following method：
It is appropriate to weigh pine needle coarse powder, 75% ethanol immersion 0.8-1.0h, heating and refluxing extraction 3 times：1st time plus 20-24 times
75% ethanol is measured, extracts 1.5-2.5h；2nd time plus 16-20 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 14-16 times
75% ethanol is measured, extracts 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, the 6- of the volume concentration of filtrate to pine needle weight
10 times of g/mL, filter and produce.
Described Folium Artemisiae Argyi extractive liquid is prepared by the following method：
It is appropriate to weigh folium artemisiae argyi, shreds, 75% ethanol immersion 0.5-0.8h, heating and refluxing extraction 3 times：1st time plus 25-28 times
75% ethanol is measured, extracts 1.0-1.5h；2nd time plus 20-24 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 16-20 times
75% ethanol is measured, extracts 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, the 5-8 of the volume concentration of filtrate to folium artemisiae argyi weight
Times g/mL, filters and produces.
Described Pericarpium Zanthoxyli extract is prepared by the following method：
It is appropriate to weigh Chinese prickly ash coarse powder, 75% ethanol immersion 0.3-0.6h, heating and refluxing extraction 3 times：1st time plus 12-15 times
75% ethanol is measured, extracts 1.5-2.0h；2nd time plus 10-12 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 8-10 times are measured
75% ethanol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, 3-6 times of the volume concentration of filtrate to Chinese prickly ash weight
G/mL, filter and produce.
Described pepper extract solution is prepared by the following method：
It is appropriate to weigh pepper coarse powder, 85% ethanol immersion 0.2-0.6h, heating and refluxing extraction 3 times：1st time plus 14-18 times
85% ethanol is measured, extracts 1.5-2.0h；2nd time plus 12-14 times measure 85% ethanol, extract 1.5-2.0h；3rd time plus 10-12 times
85% ethanol is measured, extracts 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, the 4-8 of the volume concentration of filtrate to pepper weight
Times g/mL, filters and produces.
Described garlic extract is prepared by the following method：
It is appropriate to weigh garlic, smashs to pieces, heating and refluxing extraction 3 times：1st time plus 18-22 times measure 75% ethanol, extract 1.5-
2.5h；2nd time plus 16-18 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 12-14 times measure 75% ethanol, extract 0.5-
1.0h；Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 3-6 times of g/mL of garlic weight.
Described rhizoma zingiberis extract solution is prepared by the following method：
It is appropriate to weigh rhizoma zingiberis coarse powder, 80% ethanol immersion 0.3-0.8h, heating and refluxing extraction 3 times：1st time plus 16-20 times
80% ethanol is measured, extracts 2.0-2.5h；2nd time plus 14-18 times measure 80% ethanol, extract 1.0-2.0h；3rd time plus 12-16 times
80% ethanol is measured, extracts 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, the 4-8 of the volume concentration of filtrate to rhizoma zingiberis weight
Times g/mL, filters and produces.
Described essence be lemon extract, peach flavor, green cucumber essence, flavoring rose essence, lily essence, cream jasmin france,
One or more in osmanthus flower fragrance or magnolia compound.
A kind of preparation method of emulsifiable paste for treating tinea pedis provided by the invention, comprises the following steps：
A) sodium carboxymethylcellulose 1.0-2.0g is weighed, is added in 50.0-100.0mL distilled water, 40-60 DEG C of water-bath adds
Heat, heat while stirring, it is to be mixed uniformly after, stand overnight, it is fully swelled, obtain sodium carboxymethylcellulose coagulant liquid, treat
With；
B) eucalyptus oil 0.5-4.0g, hippophae rhamnoides fruit oil 0.5-3.0g, aloe 0.5-3.0g, linseed oil 0.5- are weighed respectively
3.0g, general-purpose self-emulsifying mixed emulsifier AC-402 1.0-3.0g and all-round emulsifying agent 0.5-3.0g are mixed, and are placed in 70-95
Heating and melting in DEG C thermostat water bath, it is well mixed, as oil phase；
C) distilled water 10.0-15.0mL is measured, adds miconazole nitrate 0.1-1.0g, is placed in 70-95 DEG C of water bath with thermostatic control
Heat, be stirred to dissolve, as aqueous phase in pot；
D) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, directly
To the emulsion bases for forming uniform and smooth；
E) common fig leaf juice extract solution 1.0-3.0mL, Chinese anise extract solution 1.0-4.0mL, frutus cnidii extraction are measured respectively
Liquid 1.0-3.0mL, spina gleditsiae extract solution 1.0-3.0mL, willow leaf extract solution 1.0-3.0mL, leek extracts 1.0-4.0mL, pine
Pin extract solution 1.0-3.0mL, Folium Artemisiae Argyi extractive liquid 1.0-4.0mL, Pericarpium Zanthoxyli extract 1.0-4.0mL, pepper extract solution 1.0-
4.0mL, garlic extract 1.0-4.0mL, rhizoma zingiberis extract solution 1.0-4.0mL and light-coloured vinegar 0.5-2.0mL, stir, and must mix
Liquid；
F) 0.01-1.0g ethylparabens are weighed to be dissolved in 1.0-3.0mL 75% ethanol, obtain antiseptic solution；
G) the methyl-silicone oil 0.5-3.0g, glycerine 1.0-4.0mL, carboxymethyl that recipe quantity is separately added into emulsion bases are fine
Tie up plain sodium gel liquid, mixed liquor, antiseptic solution and 0.05-0.3mL essence prepared by step e), stir, produce treatment
The emulsifiable paste of tinea pedis.
Various composition in the present invention is as follows：
The gallic acid composition that eucalyptus oil contains has antibacterial action, to staphylococcus aureus, pneumococcus, green pus bar
Bacterium etc. has stronger bacteriostasis.Eucalyptus oil also contains a variety of anti-inflammatory active ingredients, can mitigate tissue inflammation, local necrosis subtracts
Gently；Additionally there is antioxidation.Because eucalyptus oil has efficient sterilizing effect, therefore it is widely used in pharmaceutical products.
Natural the colloidality material and water conservation lignin that aloe contains have strong osmoticum, nutrient can be helped to penetrate into
Enter skin gleditsia sinensis, there is strength cleaning, antibacterial, anti-inflammatory, detumescence, bacteria growing inhibiting, antipruritic, analgesic and other effects.
Hippophae rhamnoides fruit oil has strong disinfecting effect, while it is rich in multiple biological activities composition, there is good battalion to skin
Foster and protective effect.Also promote body metabolism composition containing abundant vitamin E etc. in hippophae rhamnoides fruit oil, not only with anti-inflammatory
Myogenic effect, also there is promotion organization regeneration, accelerating wound healing.
Containing substantial amounts of unrighted acid and vitamin E etc. in linseed oil, there is the moisture and bullet for improving cell membrane
Property, increase cellular respiration and nutrition function of exchange, there is good adaptability to skin, be easily absorbed by the skin, repair impaired skin
Skin, water conservation ventilated membrane is formed at skin, reduce skin water loss.In addition, linseed oil has anti-inflammatory, antiallergy and improvement device
Official tissue inflammation etc. acts on.
Methyl-silicone oil is non-stimulated, safe, not volatile, and surface-active is low, has good hydrophobic moistureproof defoaming work(
Energy.Silicone oil is added in ointment, penetrating power of the medicine to skin can be improved, improves drug effect.
The Bergapten that common fig leaf juice contains has antibacterial action, and research shows, common fig leaf juice ethanol extract is to thin
The inhibition of bacterium has wide spectrum it is apparent that there is good fungistatic effect to Grain-positive and gram-negative cocci or bacillus
Bacteriostasis.Its extract has different degrees of bacteriostasis to experimental bacteria respectively, wherein to staphylococcus aureus and withered grass
The bacteriostasis of bacillus is the most obvious.
Volatile oil in Chinese anise has inhibitory action for staphylococcus aureus, Escherichia coli, proteus.It is anistree
The water decoction of fennel has inhibitory action to Bacillus tuberculosis and hay bacillus, and alcohol extracting thing is in vitro to Glan positive bacteria and lattice
Blue negative bacterium, and common causative fungi have inhibitory action.
Frutus cnidii is worked hard warm-natured, dispelling wind and arresting itching, removing dampness and destroying parasites, for wet sore mange eczema etc..Frutus cnidii has anti-extensively
The effect such as bacterium and suppression fungi, is considered as treatment skin disease, the key medicine of pruritus by ancient Chinese medicine doctor from ancient times to the present.
Spina gleditsiae has strength cleaning, antibacterial, anti-inflammatory, detumescence, bacteria growing inhibiting, antipruritic, analgesic and other effects, rises simultaneously
To suppression skin surface pathogenic microorganisms and bacterium, the prevention pathogenetic effect of skin；Also have anti-inflammatory, it is antipruritic, moisten moisturizing, be anti-
Allergy etc. acts on.
Willow leaf has the effect of clearing heat for promoting eruption, in medical its decoct juice for treating tinea pedis, caused by beriberi infection it is red and swollen, suppurate etc.
Symptom.So far, Chinese medicine thinks that willow leaf plays the role of clear scattered, anti-inflammatory, removing toxic substances, is treated for inflammation.
The unique pungent fragrance of leek is the sulfide formation contained by it, and these sulfide have certain bactericidal antiphlogistic effect,
Human body is contributed to improve autoimmunity.Chinese chive juice is to staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and hay bacillus etc.
A variety of germs have obvious inhibitory action.
Pine needle has the effect of desinsection, antipruritic, and its volatile oil has the effect such as analgesia, expelling parasite, antibacterial, antiviral, can control
Respiratory tract chronic infection etc..Different solvents extract from pine needles to hay bacillus, Escherichia coli, staphylococcus aureus, saccharomycete,
Mould, aspergillus have different degrees of bacteriostasis.
Folium artemisiae argyi has the function that restraining and sterilizing bacteria, has very strong inhibitory action to a variety of pathogenic dermatophytes, can treat
Multiple dermatosis.The chlorogenic acid extracted in folium artemisiae argyi has the effect such as anti-inflammatory, antiviral, antibacterial.Folium artemisiae argyi decocting liquid treats skin scabies
Itch and dermatitis, congestion of blood vessel degree can be mitigated, mitigate local swelling and pain, mitigate itch degree, mitigate eczema symptom.Root mesh
Preceding substantial amounts of pharmacological testing proves that Blumea oil, folium artemisiae argyi flooding agent, folium artemisiae argyi are stifling to be had antiviral, mycoplasma, antibacterium, resist very
The effect of bacterium.
Chinese prickly ash has the effect of analgesic, desinsection.Its energy heat-clearing and damp-drying drug is antipruritic, antibacterial, for various scall itch.《Middle Chinese
People republic pharmacopeia》In just record Chinese prickly ash there is the multiple curative effect such as " warm in pain, desinsection are antipruritic ".Chinese prickly ash has obvious antibacterial work
With such as Diplococcus pneumopniae, staphylococcus aureus.Meanwhile Chinese prickly ash also has obvious restraining and sterilizing bacteria to some skin tineas and bacterium
Effect.Benzo phenanthridine alkaloid in Chinese prickly ash has antibacterial activity and cytotoxic activity mostly, and pepper volatile oil also has bright
Aobvious bacteriostasis.
The pipering that pepper contains can reduce the generation of inflammation and pain, and its unique fragrance is to tubercle bacillus, pneumonia
Coccus, staphylococcic growth and breeding have obvious inhibitory action.
The sulphur compound contained in garlic has strong antibacterial and anti-inflammation functions, is that antibacterial is made in the natural plants having now been found that
With most strong one kind.Volatile oil, juice, leachate and the allicin of garlic are to a variety of coccuses, bacillus (such as pertussis), mould, true
Bacterium (such as crypotococcal), virus etc. have suppression and killing action.Garlic, which has very strong suppression to fungi and killed, to be made
With.
Ginger can play a part of some antibiotic, especially more preferable to salmonella effect.Ginger extract has aobvious
The effect of suppressing dermatophyte and Trichomonas vaginalis is write, various carbuncle sore tumefacting virus can be treated.Treatment halitosis is gargled in addition, can be contained with gingerade
And periodontitis.
Light-coloured vinegar has good antibacterial and bactericidal action, can effectively prevent some diseases.Vinegar can also play well to skin
Protective effect.The record that ancient Chinese medical science is used as medicine with regard to useful vinegar is all extensive by vinegar in the clinical and among the people earthwork of modern Chinese medicine
Ground is used for a variety of prevention and treatment of diseases such as surgery, dept. of dermatology.
Miconazole nitrate category is efficient, safety, broad-spectrum antifungal medicine, nearly all has effect to pathogenic fungus, its mechanism is
Suppress the sterol synthesis of fungal cell membrane, influence permeability of cell membrane, suppress fungi growth, cause death.Miconazole nitrate can
Suppress most of fungi growth, Blastomyces, tissue milk born of the same parents Pseudomonas are extremely sensitive to its, Cryptococcus, Mycotoruloides, ball spore
Pseudomonas etc. is also sensitive to it.Miconazole nitrate can be used for dermophyte, saccharomycete and other fungus-caused skins, refer to (toe) first sense
Dye.
Sodium carboxymethylcellulose has the effects such as bonding, thickening, can be used as thickener etc..Due to its excellent property and extensively
General effect, applied to multiple fields such as chemical industry, food, medicine.
Methyl hydroxybenzoate is mainly used as cosmetics, the sterilization antiseptic of medicine.Because it has phenolic hydroxyl structure, so anti-
Bacterium performance is all stronger than benzoic acid, sorbic acid.Its mechanism of action is：The cell membrane of microorganism is destroyed, makes intracellular protein
Denaturation, and the breathing enzyme system of microbial cell and the activity of electron transmission enzyme system can be suppressed.
A kind of emulsifiable paste for treating tinea pedis provided by the invention, eucalyptus oil anti-inflammatory is sterilized in prescription, effectively mitigates injury tissue
Inflammation and local necrosis；Hippophae rhamnoides fruit oil can nourish and protect skin, anti-inflammatory myogenic, promotion organization regeneration；Aloe cleans antibacterial,
Prevent dermopathic generation, while anti-inflammatory anti-itch, moist moisturizing skin；Linseed oil can effectively reduce skin water loss, make
Skin keeps elasticity, moreover it is possible to repairs damaged skin, mitigates skin problem；Methyl-silicone oil is safe and non-stimulating, can improve medicine to skin
The penetrating power of skin, improve drug effect；Frutus cnidii, folium artemisiae argyi play the role of extensive restraining and sterilizing bacteria, external application removing dampness to stop itchin；Common fig leaf juice,
Leek, spina gleditsiae energy removing toxicity for detumescence, antibacterial bacteriostatic；Pine needle, Chinese prickly ash are warm-natured, heat-clearing and damp-drying drug, desinsection, antipruritic, antibacterial；Anistree fennel
Fragrant, rhizoma zingiberis warming spleen and stomach for dispelling cold, anti-inflammatory are antibacterial；Light-coloured vinegar has good antibacterial and bactericidal action, and good protection can also be played to skin
Effect；Willow leaf has the effect of clearing heat for promoting eruption, diuresis removing toxic substances, for treating tinea pedis, the disease such as redness suppuration caused by beriberi infection
Shape, treated available for inflammation；Garlic has very strong bactericidal action, wherein the sulphur compound contained has stronger antibacterial
Antiinflammation, garlic essence also have wide effect bactericidal action, and the allicin contained is a kind of broad-spectrum antiseptic material, have activating cell,
Increase antibacterial ability, accelerate a variety of pharmacological functions such as metabolism.
Compared with prior art, the emulsifiable paste for the treatment of tinea pedis provided by the present invention adds a variety of anti-inflammation compositions, a side
Face is by cleaning, moistening, protecting skin to reduce the growth of bacterium, fungi；On the other hand controlled further through anti-inflammation to reach
Treat tinea pedis and antipruritic effect.In addition, there are multiple nutritional components in this product, repair damaged skin while treatment, temperature
With it is non-stimulated, enhance metabolism, effectively treat tinea pedis.
Embodiment
With reference to example to further description of the present invention.
Embodiment 1
A kind of emulsifiable paste for treating tinea pedis, the raw material containing following proportioning：
The preparation of 1.1 common fig leaf juice extract solutions
Fresh fig leaf 50g is weighed, is shredded, heating and refluxing extraction 3 times：1st time plus 18 times amount water, extracts 1.0h；2nd
Secondary plus 16 times of amount water, extract 1.0h；3rd time plus 12 times amount water, extracts 0.5h；Filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration is filtered and produced to 3 times of g/mL of common fig leaf juice weight.
1.2 the preparation of Chinese anise extract solution
Weigh Chinese anise coarse powder 35g, 80% ethanol immersion 0.3h, heating and refluxing extraction 3 times：1st time plus 12 times amount
80% ethanol, extract 1.5h；2nd time plus 10 times 80% ethanol of amount, extracts 1.0h；3rd time plus 8 times 80% ethanol of amount, extraction
0.5h；Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 3 times of g/mL of Chinese anise weight.
The preparation of 1.3 frutus cnidii extract solutions
Weigh frutus cnidii 30g, 75% ethanol immersion 0.4h, heating and refluxing extraction 3 times：1st time plus 16 times 75% ethanol of amount,
Extract 1.5h；2nd time plus 14 times 75% ethanol of amount, extracts 1.0h；3rd time plus 8 times 75% ethanol of amount, extracts 0.5h；Filter every time
Filtrate, merging filtrate are crossed to obtain, the volume concentration of filtrate is filtered and produced to 4 times of g/mL of frutus cnidii weight.
The preparation of 1.4 spina gleditsiae extract solutions
Weigh spina gleditsiae coarse powder 50g, 70% ethanol immersion 0.5h, heating and refluxing extraction 3 times：1st time plus 14 times amount 70%
Ethanol, extract 1.0h；2nd time plus 12 times 70% ethanol of amount, extracts 0.5h；3rd time plus 8 times 70% ethanol of amount, extracts 0.5h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 4 times of g/mL of spina gleditsiae weight.
The preparation of 1.5 willow leaf extract solutions
Fresh willow leaf 30g is weighed, is shredded, heating and refluxing extraction 3 times：1st time plus 14 times amount water, extracts 1.5h；2nd time plus
10 times of amount water, extract 1.0h；3rd time plus 8 times amount water, extracts 0.5h；Filter to obtain filtrate, merging filtrate, the volume of filtrate every time
3 times of g/mL of willow leaf weight are concentrated into, filters and produces.
The preparation of 1.6 leek extracts
Leek 40g is weighed, is shredded, heating decocts extraction 3 times：1st time plus 10 times amount water, extracts 1.5h；2nd time plus 10 times
Water is measured, extracts 1.5h；3rd time plus 8 times amount water, extracts 0.5h；Filter to obtain filtrate, merging filtrate, the volume concentration of filtrate every time
To 4 times of g/mL of leek weight, filter and produce.
The preparation of 1.7 pine needle extracts
Weigh pine needle coarse powder 50g, 75% ethanol immersion 0.8h, heating and refluxing extraction 3 times：1st time plus 20 times 75% second of amount
Alcohol, extract 1.5h；2nd time plus 16 times 75% ethanol of amount, extracts 1.0h；3rd time plus 14 times 75% ethanol of amount, extracts 0.5h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 6 times of g/mL of pine needle weight.
The preparation of 1.8 Folium Artemisiae Argyi extractive liquids
It is appropriate to weigh folium artemisiae argyi, shreds, 75% ethanol immersion 0.5h, heating and refluxing extraction 3 times：1st time plus 25 times amount 75%
Ethanol, extract 1.0h；2nd time plus 20 times 75% ethanol of amount, extracts 1.0h；3rd time plus 16 times 75% ethanol of amount, extracts 0.5h；
Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 5 times of g/mL of folium artemisiae argyi weight.
The preparation of 1.9 Pericarpium Zanthoxyli extracts
Weigh Chinese prickly ash coarse powder 30g, 75% ethanol immersion 0.3h, heating and refluxing extraction 3 times：1st time plus 12 times 75% second of amount
Alcohol, extract 1.5h；2nd time plus 10 times 75% ethanol of amount, extracts 1.0h；3rd time plus 8 times 75% ethanol of amount, extracts 0.5h；Every time
Filtrate, merging filtrate are filtered to obtain, the volume concentration of filtrate is filtered and produced to 3 times of g/mL of Chinese prickly ash weight.
The preparation of 1.10 pepper extract solutions
Weigh pepper coarse powder 30g, 85% ethanol immersion 0.2h, heating and refluxing extraction 3 times：1st time plus 14 times 85% second of amount
Alcohol, extract 1.5h；2nd time plus 12 times 85% ethanol of amount, extracts 1.5h；3rd time plus 10 times 85% ethanol of amount, extracts 0.5h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 4 times of g/mL of pepper weight.
The preparation of 1.11 garlic extracts
Garlic 20g is weighed, is smashed to pieces, heating and refluxing extraction 3 times：1st time plus 18 times 75% ethanol of amount, extracts 1.5h；2nd time
Add 16 times of 75% ethanol of amount, extract 1.0h；3rd time plus 12 times 75% ethanol of amount, extracts 0.5h；Filtrate is filtered to obtain every time, is merged
Filtrate, the volume concentration of filtrate are filtered and produced to 3 times of g/mL of garlic weight.
The preparation of 1.12 rhizoma zingiberis extract solutions
Weigh rhizoma zingiberis coarse powder 40g, 80% ethanol immersion 0.3h, heating and refluxing extraction 3 times：1st time plus 16 times 80% second of amount
Alcohol, extract 2.0h；2nd time plus 14 times 80% ethanol of amount, extracts 1.0h；3rd time plus 12 times 80% ethanol of amount, extracts 0.5h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 4 times of g/mL of rhizoma zingiberis weight.
The preparation of the emulsifiable paste of 1.13 treatment tinea pedis
A) sodium carboxymethylcellulose 1.0g is weighed, is added in 50.0mL distilled water, 40 DEG C of heating water baths, is stirred in heating
Mix, it is to be mixed uniformly after, stand overnight, it is fully swelled, obtain sodium carboxymethylcellulose coagulant liquid, it is stand-by；
B) eucalyptus oil 0.5g, hippophae rhamnoides fruit oil 0.5g, aloe 0.5g, linseed oil 0.5g, general-purpose self-emulsifying are weighed respectively
Mixed emulsifier AC-402 1.0g and all-round emulsifying agent 0.5g are placed in heating and melting in 70 DEG C of thermostat water baths in beaker,
It is well mixed, as oil phase；
C) measure distilled water 10.0mL and add beaker, then weigh miconazole nitrate 0.1g additions, be placed in 70 DEG C of waters bath with thermostatic control
Heat, be stirred to dissolve, as aqueous phase in pot；
D) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, directly
To the emulsion bases for forming uniform and smooth；
E) measure respectively common fig leaf juice extract solution 1.0mL, Chinese anise extract solution 1.0mL, frutus cnidii extract solution 2.0mL,
Spina gleditsiae extract solution 1.0mL, willow leaf extract solution 2.0mL, leek extracts 2.0mL, pine needle extract 1.0mL, Folium Artemisiae Argyi extractive liquid
1.0mL, Pericarpium Zanthoxyli extract 2.0mL, pepper extract solution 1.0mL, garlic extract 1.0mL, rhizoma zingiberis extract solution 2.0mL and light-coloured vinegar
0.5mL is placed in beaker, is stirred, and obtains mixed liquor；
F) 0.01g ethylparabens are weighed to be dissolved in 1.0mL75% ethanol, obtain antiseptic solution；
G) methyl-silicone oil 0.5g, glycerine 1.0mL, sodium carboxymethylcellulose coagulant liquid, step are separately added into emulsion bases
Rapid mixed liquor e) prepared, antiseptic solution, lemon extract 0.05mL, stir, you can must treat the emulsifiable paste of tinea pedis.
Embodiment 2
A kind of emulsifiable paste for treating tinea pedis, the raw material containing following proportioning：
The preparation of 2.1 common fig leaf juice extract solutions
Fresh fig leaf 50g is weighed, is shredded, heating and refluxing extraction 3 times：1st time plus 20 times amount water, extracts 1.0h；2nd
Secondary plus 18 times of amount water, extract 1.0h；3rd time plus 14 times amount water, extracts 1.0h；Filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration is filtered and produced to 4 times of g/mL of common fig leaf juice weight.
The preparation of 2.2 Chinese anise extract solutions
Weigh Chinese anise coarse powder 30g, 80% ethanol immersion 0.5h, heating and refluxing extraction 3 times：1st time plus 14 times amount
80% ethanol, extract 1.5h；2nd time plus 10 times 80% ethanol of amount, extracts 1.5h；3rd time plus 8 times 80% ethanol of amount, extraction
1.0h；Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 4 times of g/mL of Chinese anise weight.
The preparation of 2.3 frutus cnidii extract solutions
Weigh frutus cnidii 60g, 75% ethanol immersion 0.6h, heating and refluxing extraction 3 times：1st time plus 18 times 75% ethanol of amount,
Extract 1.5h；2nd time plus 15 times 75% ethanol of amount, extracts 1.0h；3rd time plus 10 times 75% ethanol of amount, extracts 1.0h；Filter every time
Filtrate, merging filtrate are crossed to obtain, the volume concentration of filtrate is filtered and produced to 5 times of g/mL of frutus cnidii weight.
The preparation of 2.4 spina gleditsiae extract solutions
Weigh spina gleditsiae coarse powder 50g, 70% ethanol immersion 0.8h, heating and refluxing extraction 3 times：1st time plus 16 times amount 70%
Ethanol, extract 1.5h；2nd time plus 14 times 70% ethanol of amount, extracts 1.0h；3rd time plus 10 times 70% ethanol of amount, extracts 1.0h；
Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 6 times of g/mL of spina gleditsiae weight.
The preparation of 2.5 willow leaf extract solutions
Fresh willow leaf 40g is weighed, is shredded, heating and refluxing extraction 3 times：1st time plus 15 times amount water, extracts 1.5h；2nd time plus
12 times of amount water, extract 1.0h；3rd time plus 9 times amount water, extracts 1.0h；Filter to obtain filtrate, merging filtrate, the volume of filtrate every time
4 times of g/mL of willow leaf weight are concentrated into, filters and produces.
The preparation of 2.6 leek extracts
Leek 35g is weighed, is shredded, heating decocts extraction 3 times：1st time plus 12 times amount water, extracts 1.5h；2nd time plus 12 times
Water is measured, extracts 1.5h；3rd time plus 10 times amount water, extracts 1.0h；Filter to obtain filtrate, merging filtrate, the volume concentration of filtrate every time
To 5 times of g/mL of leek weight, filter and produce.
The preparation of 2.7 pine needle extracts
Weigh pine needle coarse powder 50g, 75% ethanol immersion 0.8h, heating and refluxing extraction 3 times：1st time plus 22 times 75% second of amount
Alcohol, extract 2.0h；2nd time plus 18 times 75% ethanol of amount, extracts 1.0h；3rd time plus 15 times 75% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 8 times of g/mL of pine needle weight.
The preparation of 2.8 Folium Artemisiae Argyi extractive liquids
Folium artemisiae argyi 75g is weighed, is shredded, 75% ethanol immersion 0.6h, heating and refluxing extraction 3 times：1st time plus 26 times 75% second of amount
Alcohol, extract 1.5h；2nd time plus 22 times 75% ethanol of amount, extracts 1.0h；3rd time plus 18 times 75% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 6 times of g/mL of folium artemisiae argyi weight.
The preparation of 2.9 Pericarpium Zanthoxyli extracts
Weigh Chinese prickly ash coarse powder 30g, 75% ethanol immersion 0.5h, heating and refluxing extraction 3 times：1st time plus 14 times 75% second of amount
Alcohol, extract 2.0h；2nd time plus 10 times 75% ethanol of amount, extracts 1.5h；3rd time plus 8 times 75% ethanol of amount, extracts 1.0h；Every time
Filtrate, merging filtrate are filtered to obtain, the volume concentration of filtrate is filtered and produced to 5 times of g/mL of Chinese prickly ash weight.
The preparation of 2.10 pepper extract solutions
Weigh pepper coarse powder 40g, 85% ethanol immersion 0.4h, heating and refluxing extraction 3 times：1st time plus 16 times 85% second of amount
Alcohol, extract 2.0h；2nd time plus 12 times 85% ethanol of amount, extracts 1.5h；3rd time plus 10 times 85% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 6 times of g/mL of pepper weight.
The preparation of 2.11 garlic extracts
Garlic 30g is weighed, is smashed to pieces, heating and refluxing extraction 3 times：1st time plus 20 times 75% ethanol of amount, extracts 2.0h；2nd time
Add 16 times of 75% ethanol of amount, extract 1.0h；3rd time plus 12 times 75% ethanol of amount, extracts 1.0h；Filtrate is filtered to obtain every time, is merged
Filtrate, the volume concentration of filtrate are filtered and produced to 4 times of g/mL of garlic weight.
The preparation of 2.12 rhizoma zingiberis extract solutions
Weigh rhizoma zingiberis coarse powder 20g, 80% ethanol immersion 0.6h, heating and refluxing extraction 3 times：1st time plus 18 times 80% second of amount
Alcohol, extract 2.0h；2nd time plus 16 times 80% ethanol of amount, extracts 2.0h；3rd time plus 14 times 80% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 5 times of g/mL of rhizoma zingiberis weight.
The preparation of the emulsifiable paste of 2.13 treatment tinea pedis
A) sodium carboxymethylcellulose 1.5g is weighed, is added in 80.0mL distilled water, 50 DEG C of heating water baths, is stirred in heating
Mix, it is to be mixed uniformly after, stand overnight, it is fully swelled, obtain sodium carboxymethylcellulose coagulant liquid, it is stand-by；
B) eucalyptus oil 2.0g, hippophae rhamnoides fruit oil 1.0g, aloe 2.0g, linseed oil 2.0g, general-purpose self-emulsifying are weighed respectively
Mixed emulsifier AC-402 2.5g and all-round emulsifying agent 2.0g are placed in heating and melting in 85 DEG C of thermostat water baths in beaker,
It is well mixed, as oil phase；
C) measure distilled water 12.0mL and add beaker, then weigh miconazole nitrate 0.5g additions, be placed in 85 DEG C of waters bath with thermostatic control
Heat, be stirred to dissolve, as aqueous phase in pot；
D) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, directly
To the emulsion bases for forming uniform and smooth；
E) measure respectively common fig leaf juice extract solution 2.0mL, Chinese anise extract solution 4.0mL, frutus cnidii extract solution 2.0mL,
Spina gleditsiae extract solution 3.0mL, willow leaf extract solution 2.0mL, leek extracts 2.0mL, pine needle extract 3.0mL, Folium Artemisiae Argyi extractive liquid
1.0mL, Pericarpium Zanthoxyli extract 3.0mL, pepper extract solution 2.0mL, garlic extract 2.0mL, rhizoma zingiberis extract solution 2.0mL and light-coloured vinegar
1.0mL is placed in beaker, is stirred, and obtains mixed liquor；
F) 0.08g ethylparabens are weighed to be dissolved in 2.0mL75% ethanol, obtain antiseptic solution；
G) the methyl-silicone oil 1.0g, glycerine 2.0mL, sodium carboxymethylcellulose that recipe quantity is separately added into emulsion bases coagulate
Mixed liquor, antiseptic solution, green cucumber essence 0.1mL prepared by glue, step e), stirs, you can must treat the breast of tinea pedis
Cream.
Embodiment 3
A kind of emulsifiable paste for treating tinea pedis, the raw material containing following proportioning：
3.1 the preparation of common fig leaf juice extract solution
Fresh fig leaf 50g is weighed, is shredded, heating and refluxing extraction 3 times：1st time plus 22 times amount water, extracts 1.5h；2nd
Secondary plus 20 times of amount water, extract 1.5h；3rd time plus 16 times amount water, extracts 1.0h；Filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration is filtered and produced to 5 times of g/mL of common fig leaf juice weight.
The preparation of 3.2 Chinese anise extract solutions
Weigh Chinese anise coarse powder 30g, 80% ethanol immersion 0.6h, heating and refluxing extraction 3 times：1st time plus 16 times amount
80% ethanol, extract 2.0h；2nd time plus 12 times 80% ethanol of amount, extracts 1.5h；3rd time plus 10 times 80% ethanol of amount, extraction
1.0h；Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 8 times of g/mL of Chinese anise weight.
The preparation of 3.3 frutus cnidii extract solutions
Weigh frutus cnidii 50g, 75% ethanol immersion 0.8h, heating and refluxing extraction 3 times：1st time plus 20 times 75% ethanol of amount,
Extract 2.0h；2nd time plus 16 times 75% ethanol of amount, extracts 1.5h；3rd time plus 12 times 75% ethanol of amount, extracts 1.0h；Filter every time
Filtrate, merging filtrate are crossed to obtain, the volume concentration of filtrate is filtered and produced to 6 times of g/mL of frutus cnidii weight.
The preparation of 3.4 spina gleditsiae extract solutions
Weigh spina gleditsiae coarse powder 35g, 70% ethanol immersion 1.0h, heating and refluxing extraction 3 times：1st time plus 18 times amount 70%
Ethanol, extract 1.5h；2nd time plus 14 times 70% ethanol of amount, extracts 1.0h；3rd time plus 12 times 70% ethanol of amount, extracts 1.0h；
Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 8 times of g/mL of spina gleditsiae weight.
The preparation of 3.5 willow leaf extract solutions
Fresh willow leaf 50g is weighed, is shredded, heating and refluxing extraction 3 times：1st time plus 16 times amount water, extracts 2.0h；2nd time plus
12 times of amount water, extract 1.5h；3rd time plus 10 times amount water, extracts 1.0h；Filter to obtain filtrate, merging filtrate, the volume of filtrate every time
6 times of g/mL of willow leaf weight are concentrated into, filters and produces.
The preparation of 3.6 leek extracts
Leek 30g is weighed, is shredded, heating decocts extraction 3 times：1st time plus 14 times amount water, extracts 2.0h；2nd time plus 12 times
Water is measured, extracts 2.0h；3rd time plus 10 times amount water, extracts 1.0h；Filter to obtain filtrate, merging filtrate, the volume concentration of filtrate every time
To 8 times of g/mL of leek weight, filter and produce.
The preparation of 3.7 pine needle extracts
Weigh pine needle coarse powder 50g, 75% ethanol immersion 1.0h, heating and refluxing extraction 3 times：1st time plus 24 times 75% second of amount
Alcohol, extract 2.5h；2nd time plus 20 times 75% ethanol of amount, extracts 1.5h；3rd time plus 16 times 75% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 10 times of g/mL of pine needle weight.
The preparation of 3.8 Folium Artemisiae Argyi extractive liquids
Folium artemisiae argyi 70g is weighed, is shredded, 75% ethanol immersion 0.8h, heating and refluxing extraction 3 times：1st time plus 28 times 75% second of amount
Alcohol, extract 1.5h；2nd time plus 24 times 75% ethanol of amount, extracts 1.5h；3rd time plus 20 times 75% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 8 times of g/mL of folium artemisiae argyi weight.
The preparation of 3.9 Pericarpium Zanthoxyli extracts
Weigh Chinese prickly ash coarse powder 40g, 75% ethanol immersion 0.6h, heating and refluxing extraction 3 times：1st time plus 15 times 75% second of amount
Alcohol, extract 2.0h；2nd time plus 12 times 75% ethanol of amount, extracts 1.5h；3rd time plus 10 times 75% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 6 times of g/mL of Chinese prickly ash weight.
The preparation of 3.10 pepper extract solutions
Weigh pepper coarse powder 30g, 85% ethanol immersion 0.6h, heating and refluxing extraction 3 times：1st time plus 18 times 85% second of amount
Alcohol, extract 2.0h；2nd time plus 14 times 85% ethanol of amount, extracts 2.0h；3rd time plus 12 times 85% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 8 times of g/mL of pepper weight.
The preparation of 3.11 garlic extracts
Garlic 30g is weighed, is smashed to pieces, heating and refluxing extraction 3 times：1st time plus 22 times 75% ethanol of amount, extracts 2.5h；2nd time
Add 18 times of 75% ethanol of amount, extract 1.5h；3rd time plus 14 times 75% ethanol of amount, extracts 1.0h；Filtrate is filtered to obtain every time, is merged
Filtrate, the volume concentration of filtrate are filtered and produced to 6 times of g/mL of garlic weight.
The preparation of 3.12 rhizoma zingiberis extract solutions
Weigh rhizoma zingiberis coarse powder 30g, 80% ethanol immersion 0.8h, heating and refluxing extraction 3 times：1st time plus 20 times 80% second of amount
Alcohol, extract 2.5h；2nd time plus 18 times 80% ethanol of amount, extracts 2.0h；3rd time plus 16 times 80% ethanol of amount, extracts 1.0h；Often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 8 times of g/mL of rhizoma zingiberis weight.
The preparation of the emulsifiable paste of 3.13 treatment tinea pedis
A) sodium carboxymethylcellulose 2.0g is weighed, is added in 100.0mL distilled water, 60 DEG C of heating water baths, in heating
Stirring, it is to be mixed uniformly after, stand overnight, it is fully swelled, obtain sodium carboxymethylcellulose coagulant liquid, it is stand-by；
B) eucalyptus oil 4.0g, hippophae rhamnoides fruit oil 3.0g, aloe 3.0g, linseed oil 3.0g, general-purpose self-emulsifying are weighed respectively
Mixed emulsifier AC-402 3.0g and all-round emulsifying agent 3.0g are placed in heating and melting in 95 DEG C of thermostat water baths in beaker,
It is well mixed, as oil phase；
C) measure distilled water 15.0mL and add beaker, then weigh miconazole nitrate 1.0g additions, be placed in 95 DEG C of waters bath with thermostatic control
Heat, be stirred to dissolve, as aqueous phase in pot；
D) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, directly
To the emulsion bases for forming uniform and smooth；
E) measure respectively common fig leaf juice extract solution 3.0mL, Chinese anise extract solution 4.0mL, frutus cnidii extract solution 3.0mL,
Spina gleditsiae extract solution 3.0mL, willow leaf extract solution 3.0mL, leek extracts 4.0mL, pine needle extract 3.0mL, Folium Artemisiae Argyi extractive liquid
4.0mL, Pericarpium Zanthoxyli extract 4.0mL, pepper extract solution 4.0mL, garlic extract 4.0mL, rhizoma zingiberis extract solution 4.0mL and light-coloured vinegar
2.0mL is placed in beaker, is stirred, and obtains mixed liquor；
F) 1.0g ethylparabens are weighed to be dissolved in 3.0mL75% ethanol, obtain antiseptic solution；
G) the methyl-silicone oil 3.0g, glycerine 4.0mL, sodium carboxymethylcellulose that recipe quantity is separately added into emulsion bases coagulate
Mixed liquor, antiseptic solution, magnolia compound 0.3mL prepared by glue, step e), stirs, you can must treat the breast of tinea pedis
Cream.
Embodiment 4
The physical and chemical index of embodiment 1,2,3 is as follows：
4.1 character
The white emulsifiable paste shape of this product breast, viscosity is suitable, and fine and smooth uniform, stretchability is good
4.2pH values check
A small amount of emulsifiable paste is dipped with the pH test paper of wetting, it is 6-7 to measure pH value.
4.3 irritation tests, anaphylaxis experiment
Small white mouse back cuts off hair, smears the tinea pedis emulsifiable paste prepared by embodiment 1,2,3 respectively in cutting plucked position, and
It is not coated with position to be compared, as a result nonirritant and allergic reaction.
Beriberi paste made by Example is applied on volunteer (20-70 year, 50 people) instep in right amount, is seen after spending 30 minutes
Examine, do not occur phenomena such as rubescent, dermexanthesis, foaming.
4.4 room temperatures place experiment
The made tinea pedis emulsifiable paste of embodiment 1,2,3 is placed in bottle, is stored at room temperature investigation 6 months, no lamination, after
Feel unchanged, smell is unchanged.
Embodiment 5
The emulsifiable paste resultant effect is investigated
Following with probation the effect of feeling to evaluate emulsifiable paste that embodiment 1,2,3 produces.Scored using opinion poll
Method, the target group of 240 20-70 year age brackets are chosen as object on probation, three groups are divided at random, respectively using embodiment
1st, the emulsifiable paste of 2, the 3 treatment tinea pedis prepared.Daily using twice, usage time is one week.Every using effect total score is 5 points：5
It is divided into best result, represents fine, it is very satisfied；4 points are preferable；3 points are to receive；Less than 3 points are bad, it is impossible to are received.
It is every average below.It the results are shown in Table 1：
The resultant effect of table 1 is investigated
In summary, the emulsifiable paste viscosity of the treatment tinea pedis made by the present invention is suitable, slim and graceful water profit, fine and smooth uniform, applies
Malleability is good, and refrigerant comfortable, stability is good, can treat pruitus, dermatitis, fungi, mitigates congestion of blood vessel degree, mitigates local
Pain, reach effective therapeutic effect.
Claims (10)
1. a kind of emulsifiable paste for treating tinea pedis, it is characterised in that the emulsifiable paste of the treatment tinea pedis contains the raw material of following proportioning：
2. it is according to claim 1 treatment tinea pedis emulsifiable paste, it is characterised in that described common fig leaf juice extract solution by with
It is prepared by lower section method：
It is appropriate to weigh fresh fig leaf, shreds, heating and refluxing extraction 3 times：1st time plus 18-22 times measure water, extract 1.0-
1.5h；2nd time plus 16-20 times measure water, extract 1.0-1.5h；3rd time plus 12-16 times measure water, extract 0.5-1.0h；Filtration every time
Filtrate, merging filtrate are obtained, the volume concentration of filtrate is filtered and produced to 3-5 times of g/mL of common fig leaf juice weight.
3. the emulsifiable paste for the treatment of tinea pedis according to claim 1 or 2, it is characterised in that described Chinese anise extract solution leads to
Cross following methods preparation：
It is appropriate to weigh Chinese anise coarse powder, 80% ethanol immersion 0.3-0.6h, heating and refluxing extraction 3 times：1st time plus 12-16 times
80% ethanol is measured, extracts 1.5-2.0h；2nd time plus 10-12 times measure 80% ethanol, extract 1.0-1.5h；3rd time plus 8-10 times are measured
80% ethanol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, the volume concentration of filtrate to Chinese anise weight
3-8 times of g/mL, filters and produces.
4. the emulsifiable paste of the treatment tinea pedis according to claim any one of 1-3, it is characterised in that described frutus cnidii extract solution
It is prepared by the following method：
It is appropriate to weigh frutus cnidii, 75% ethanol immersion 0.4-0.8h, heating and refluxing extraction 3 times：1st time plus 16-20 times measure 75%
Ethanol, extract 1.5-2.0h；2nd time plus 14-16 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 8-12 times measure 75% second
Alcohol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, 4-6 times of g/ of the volume concentration of filtrate to frutus cnidii weight
ML, filter and produce.
5. the emulsifiable paste of the treatment tinea pedis according to claim any one of 1-4, it is characterised in that described spina gleditsiae extract solution
It is prepared by the following method：
It is appropriate to weigh spina gleditsiae coarse powder, 70% ethanol immersion 0.5-1.0h, heating and refluxing extraction 3 times：1st time plus 14-18 times are measured
70% ethanol, extract 1.0-1.5h；2nd time plus 12-14 times measure 70% ethanol, extract 0.5-1.0h；3rd time plus 8-12 times are measured
70% ethanol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, the 4-8 of the volume concentration of filtrate to spina gleditsiae weight
Times g/mL, filters and produces.
6. the emulsifiable paste of the treatment tinea pedis according to claim any one of 1-5, it is characterised in that described willow leaf extract solution leads to
Cross following methods preparation：
It is appropriate to weigh fresh willow leaf, shreds, heating and refluxing extraction 3 times：1st time plus 14-16 times measure water, extract 1.5-2.0h；2nd
It is secondary to add 10-12 times to measure water, extract 1.0-1.5h；3rd time plus 8-10 times measure water, extract 0.5-1.0h；Filtrate is filtered to obtain every time, is closed
And filtrate, the volume concentration of filtrate are filtered and produced to 3-6 times of g/mL of willow leaf weight；
Described leek extracts are prepared by the following method：
It is appropriate to weigh leek, shreds, heating decocts extraction 3 times：1st time plus 10-14 times measure water, extract 1.5-2.0h；2nd time plus
10-14 times is measured water, extracts 1.5-2.0h；3rd time plus 8-12 times measure water, extract 0.5-1.0h；Filtrate is filtered to obtain every time, merges filter
Liquid, the volume concentration of filtrate are filtered and produced to 4-8 times of g/mL of leek weight.
7. the emulsifiable paste of the treatment tinea pedis according to claim any one of 1-6, it is characterised in that described pine needle extract leads to
Cross following methods preparation：
It is appropriate to weigh pine needle coarse powder, 75% ethanol immersion 0.8-1.0h, heating and refluxing extraction 3 times：1st time plus 20-24 times are measured
75% ethanol, extract 1.5-2.5h；2nd time plus 16-20 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 14-16 times are measured
75% ethanol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, the 6-10 of the volume concentration of filtrate to pine needle weight
Times g/mL, filters and produces；
Described Folium Artemisiae Argyi extractive liquid is prepared by the following method：
It is appropriate to weigh folium artemisiae argyi, shreds, 75% ethanol immersion 0.5-0.8h, heating and refluxing extraction 3 times：1st time plus 25-28 times are measured
75% ethanol, extract 1.0-1.5h；2nd time plus 20-24 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 16-20 times are measured
75% ethanol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, 5-8 times of the volume concentration of filtrate to folium artemisiae argyi weight
G/mL, filter and produce.
8. the emulsifiable paste of the treatment tinea pedis according to claim any one of 1-7, it is characterised in that described Pericarpium Zanthoxyli extract leads to
Cross following methods preparation：
It is appropriate to weigh Chinese prickly ash coarse powder, 75% ethanol immersion 0.3-0.6h, heating and refluxing extraction 3 times：1st time plus 12-15 times are measured
75% ethanol, extract 1.5-2.0h；2nd time plus 10-12 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 8-10 times are measured
75% ethanol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, 3-6 times of the volume concentration of filtrate to Chinese prickly ash weight
G/mL, filter and produce；
Described pepper extract solution is prepared by the following method：
It is appropriate to weigh pepper coarse powder, 85% ethanol immersion 0.2-0.6h, heating and refluxing extraction 3 times：1st time plus 14-18 times are measured
85% ethanol, extract 1.5-2.0h；2nd time plus 12-14 times measure 85% ethanol, extract 1.5-2.0h；3rd time plus 10-12 times are measured
85% ethanol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, 4-8 times of the volume concentration of filtrate to pepper weight
G/mL, filter and produce.
9. the emulsifiable paste of the treatment tinea pedis according to claim any one of 1-8, it is characterised in that described garlic extract leads to
Cross following methods preparation：
It is appropriate to weigh garlic, smashs to pieces, heating and refluxing extraction 3 times：1st time plus 18-22 times measure 75% ethanol, extract 1.5-2.5h；
2nd time plus 16-18 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 12-14 times measure 75% ethanol, extract 0.5-1.0h；
Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 3-6 times of g/mL of garlic weight；
Described rhizoma zingiberis extract solution is prepared by the following method：
It is appropriate to weigh rhizoma zingiberis coarse powder, 80% ethanol immersion 0.3-0.8h, heating and refluxing extraction 3 times：1st time plus 16-20 times are measured
80% ethanol, extract 2.0-2.5h；2nd time plus 14-18 times measure 80% ethanol, extract 1.0-2.0h；3rd time plus 12-16 times are measured
80% ethanol, extract 0.5-1.0h；Filter to obtain filtrate every time, merging filtrate, 4-8 times of the volume concentration of filtrate to rhizoma zingiberis weight
G/mL, filter and produce.
A kind of 10. preparation method of the emulsifiable paste of the treatment tinea pedis described in any one of claim 1-9, it is characterised in that the system
Preparation Method comprises the following steps：
A) sodium carboxymethylcellulose 1.0-2.0g is weighed, is added in 50.0-100.0mL distilled water, 40-60 DEG C of heating water bath,
Heat while stirring, it is to be mixed uniformly after, stand overnight, it is fully swelled, obtain sodium carboxymethylcellulose coagulant liquid, it is stand-by；
B) eucalyptus oil 0.5-4.0g, hippophae rhamnoides fruit oil 0.5-3.0g, aloe 0.5-3.0g, linseed oil 0.5- are weighed respectively
3.0g, general-purpose self-emulsifying mixed emulsifier AC-402 1.0-3.0g and all-round emulsifying agent 0.5-3.0g are mixed, and are placed in 70-95
Heating and melting in DEG C thermostat water bath, it is well mixed, as oil phase；
C) distilled water 10.0-15.0mL is measured, adds miconazole nitrate 0.1-1.0g, is placed in 70-95 DEG C of thermostat water bath
Heating, is stirred to dissolve, as aqueous phase；
D) when oil phase reaches mutually synthermal with aqueous phase, aqueous phase is added in oil phase into thread shape, stirred while adding, until shape
Into the emulsion bases of uniform and smooth；
E) common fig leaf juice extract solution 1.0-3.0mL, Chinese anise extract solution 1.0-4.0mL, frutus cnidii extract solution are measured respectively
1.0-3.0mL, spina gleditsiae extract solution 1.0-3.0mL, willow leaf extract solution 1.0-3.0mL, leek extracts 1.0-4.0mL, pine needle
Extract solution 1.0-3.0mL, Folium Artemisiae Argyi extractive liquid 1.0-4.0mL, Pericarpium Zanthoxyli extract 1.0-4.0mL, pepper extract solution 1.0-4.0mL,
Garlic extract 1.0-4.0mL, rhizoma zingiberis extract solution 1.0-4.0mL and light-coloured vinegar 0.5-2.0mL, stir, obtain mixed liquor；
F) 0.01-1.0g ethylparabens are weighed to be dissolved in 1.0-3.0mL 75% ethanol, obtain antiseptic solution；
G) the methyl-silicone oil 0.5-3.0g, glycerine 1.0-4.0mL, carboxymethyl cellulose of recipe quantity are separately added into emulsion bases
Mixed liquor, antiseptic solution and 0.05-0.3mL essence prepared by sodium gel liquid, step e), stirs, produces treatment tinea pedis
Emulsifiable paste.
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| CN115518127A (en) * | 2022-10-25 | 2022-12-27 | 皖南医学院 | Antibacterial, anti-inflammatory, detumescence and itching relieving cream and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456994A (en) * | 2015-12-23 | 2016-04-06 | 潘芮 | Foot health care lotion Chinese medicinal composition |
| CN106215060A (en) * | 2016-08-25 | 2016-12-14 | 皖南医学院 | One treats verruca plana ointment and preparation method thereof |
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2017
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105456994A (en) * | 2015-12-23 | 2016-04-06 | 潘芮 | Foot health care lotion Chinese medicinal composition |
| CN106215060A (en) * | 2016-08-25 | 2016-12-14 | 皖南医学院 | One treats verruca plana ointment and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115518127A (en) * | 2022-10-25 | 2022-12-27 | 皖南医学院 | Antibacterial, anti-inflammatory, detumescence and itching relieving cream and preparation method thereof |
| CN115518127B (en) * | 2022-10-25 | 2023-09-05 | 皖南医学院 | Antibacterial, anti-inflammatory, detumescence and antipruritic cream and preparation method thereof |
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