CN107496792A - A kind of gel of antiphlogistic antibacterial treatment onychomycosis and preparation method thereof - Google Patents
A kind of gel of antiphlogistic antibacterial treatment onychomycosis and preparation method thereof Download PDFInfo
- Publication number
- CN107496792A CN107496792A CN201710754237.2A CN201710754237A CN107496792A CN 107496792 A CN107496792 A CN 107496792A CN 201710754237 A CN201710754237 A CN 201710754237A CN 107496792 A CN107496792 A CN 107496792A
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- China
- Prior art keywords
- extract
- time plus
- filtrate
- ethanol
- onychomycosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 208000010195 Onychomycosis Diseases 0.000 title claims abstract description 55
- 201000005882 tinea unguium Diseases 0.000 title claims abstract description 55
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 126
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 17
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims abstract description 6
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Classifications
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Abstract
The invention provides gel of a kind of antiphlogistic antibacterial treatment onychomycosis and preparation method thereof, described gel contains following material：HPMC, sodium carboxymethylcellulose, glycerine, azone, miconazole nitrate, aloe, hippophae rhamnoides fruit oil, light-coloured vinegar, garlic extract, Radix Sophorae Flavescentis extractive liquid, lopseed extract solution, Pericarpium Zanthoxyli extract, tuber of stemona extract solution, Folium Artemisiae Argyi extractive liquid, fruit of summer cypress extract solution, balsamine extract solution, distilled water, 75% ethanol, urea, methyl hydroxybenzoate and ethylparaben.Compared with prior art, gel provided by the invention absorbs fast, there is good compliance, preventing and treating to onychomycosis is curative for effect, with anti-inflammatory, antibacterial, the quality for improving nail and color and treatment tinea pedis and other effects, the onychomycosis of patient can be made to be significantly improved, immunity is effectively improved.
Description
Technical field
The present invention relates to a kind of gel, and in particular to a kind of gel of antiphlogistic antibacterial treatment onychomycosis and its preparation side
Method.
Background technology
Onychomycosis is the nail as caused by the pathomycetes such as dermatophytes, saccharomycete and non-dermatophytes or toenail infection.Scratching
Cause to infect a kind of most common reason that fungi is generation onychomycosis, such as patient has the ringworm of the foot or jock itch, due to itch unbearably
Conventional finger nail is scratched, and can be stained with many pathomycetes on such finger nail, and fungi will take advantage of a weak point, and invades nail or toenail
The skin of surrounding, developed by the growth of nail or toenail, simultaneously further growth and breeding in deck is progressed into, until destroying
Whole deck, form onychomycosis.The nail of onychomycosis patient shows as nail colour and paramophia, and deck tarnishes, and increases
Thick significantly, with the passing of time deck becomes fragile and breakage comes off, and is uneven more in canescence, surface.
The method for the treatment of onychomycosis has oral drug therapy, pulls out first treatment and external medication etc. at present.Oral medicine is normal
There are Sporanox, hydrochloric acid spy than antifungals such as resistance to phenol, Fluconazoles, but the course for the treatment of is long, there is certain pair to body
Effect.External used medicine in the market is mostly prepared by Western medicine, and excitant is larger.It is high that probability is recurred after treatment,
And need ceaselessly to scrape first during treating, add medicine to and then pack together, seriously affect the routine work and life of patient.
Therefore, the product of a new safe and efficient treatment onychomycosis is developed, before not only there is very wide market
Scape, and the Gospel that can be taken to the patient for more enduring onychomycosis puzzlement to the fullest extent.
The content of the invention
It is an object of the invention to provide a kind of gel of antiphlogistic antibacterial treatment onychomycosis, contain a variety of anti-inflammations
Natural constituents, have no side effect, therapeutic effect is good.
Present invention also offers a kind of preparation method of the gel of antiphlogistic antibacterial treatment onychomycosis.
A kind of gel of antiphlogistic antibacterial treatment onychomycosis provided by the invention, include the raw material components of following proportionings：
Described garlic extract is prepared by the following method：
It is appropriate to weigh garlic, smashs to pieces, is soaked in water after 0.4-0.8h, heating and refluxing extraction 3 times：1st time plus 18-20 times are measured
Water, extract 1.0-2.0h；2nd time plus 12-18 times measure water, extract 1.0-2.0h；3rd time plus 8-12 times measure water, extract 0.5-
1.0h, filters to obtain filtrate, merging filtrate every time, and the volume concentration of filtrate is filtered and produced to 3-5 times of g/mL of garlic quality.
Described Radix Sophorae Flavescentis extractive liquid is prepared by the following method：
It is appropriate to weigh kuh-seng coarse powder, after adding the ethanol of volume fraction 75% immersion 0.5-1.0h, heating and refluxing extraction 3 times：1st
It is secondary to add 16-18 times to measure 75% ethanol, extract 1.5-2.0h；2nd time plus 12-14 times measure 75% ethanol, extract 1.0-1.5h；3rd
It is secondary to add 12-14 times to measure 75% ethanol, 0.5-1.0h is extracted, filtrate is filtered to obtain every time, merging filtrate, is concentrated under reduced pressure into kuh-seng quality
4-6 times of g/mL, filter and produce.
Described lopseed extract solution is prepared by the following method：
It is appropriate to weigh lopseed, shreds, after soaking 0.3-0.6h, heating and refluxing extraction 3 times：1st time plus 22-25 times
Water is measured, extracts 1.0-2.0h；2nd time plus 20-22 times measure water, extract 1.0-2.0h；3rd time plus 18-20 times measure water, extract 0.5-
1.0h, filters to obtain filtrate, merging filtrate every time, and the volume concentration of filtrate is filtered and produced to 3-5 times of g/mL of lopseed quality.
Described Pericarpium Zanthoxyli extract is prepared by the following method：
It is appropriate to weigh Chinese prickly ash coarse powder, after adding 75% ethanol immersion 0.3-0.9h, heating and refluxing extraction 3 times：1st time plus 12-
16 times of 75% ethanol of amount, extract 1.0-2.0h；2nd time plus 10-12 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 8-10
Times 75% ethanol of amount, extracts 0.5-1.0h, filters to obtain filtrate every time, merging filtrate, is concentrated under reduced pressure into 2-6 times of g/ of Chinese prickly ash quality
ML, filter and produce.
Described tuber of stemona extract solution is prepared by the following method：
It is appropriate to weigh tuber of stemona coarse powder, soaks 0.4-0.6h, heating and refluxing extraction 3 times：1st time plus 15-17 times measure water, extract
1.5-2.0h；2nd time plus 13-15 times measure water, extract 1.0-1.5h；3rd time plus 10-13 times measure water, extract 1.0-1.5h, every time
Filtrate, merging filtrate are filtered to obtain, the volume concentration of filtrate is filtered and produced to 4-7 times of g/mL of tuber of stemona quality.
Described Folium Artemisiae Argyi extractive liquid is prepared by the following method：
It is appropriate to weigh folium artemisiae argyi, shreds, after soaking 0.5-0.8h, heating and refluxing extraction 3 times：1st time plus 18-20 times are measured
Water, extract 1.0-2.0h；2nd time plus 15-18 times measure water, extract 1.0-1.5h；3rd time plus 8-15 times measure water, extract 0.5-
1.0h, filters to obtain filtrate, merging filtrate every time, and the volume concentration of filtrate is filtered and produced to 3-6 times of g/mL of folium artemisiae argyi quality.
Described fruit of summer cypress extract solution is prepared by the following method：
It is appropriate to weigh the fruit of summer cypress, soaks 0.2-0.8h, heating and refluxing extraction 3 times：1st time plus 16-20 times measure water, carry
Take 1.5-2.5h；2nd time plus 12-16 times measure water, extract 1.0-1.5h；3rd time plus 8-12 times measure water, extract 1.0-1.5h, often
Secondary to filter to obtain filtrate, merging filtrate, the volume concentration of filtrate is filtered and produced to 2-4 times of g/mL of summer cypress protonatomic mass.
Described balsamine extract solution is prepared by the following method：
It is appropriate to weigh balsamine, shreds, after adding 75% ethanol immersion 0.4-0.6h, heating and refluxing extraction 3 times：1st time plus
18-20 times is measured 75% ethanol, extracts 1.0-2.0h；2nd time plus 14-18 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus
8-12 times is measured 75% ethanol, extracts 0.5-1.0h, filters to obtain filtrate, merging filtrate every time, and vacuum distillation is concentrated into balsamine matter
6-8 times of g/mL of amount, filters and produces.
A kind of preparation method of the gel of antiphlogistic antibacterial treatment onychomycosis provided by the invention, comprises the following steps：
A) weigh HPMC 0.1-1.0g to be added in 20.0-35.0mL distilled water, stand overnight, make it
Fully swelling, dissolving, obtain HPMC coagulant liquid, stand-by；
B) sodium carboxymethylcellulose 0.1-1.0g is weighed, is added in 30.0-60.0mL distilled water, stands overnight, make it
Fully swelling, dissolving, obtain sodium carboxymethylcellulose coagulant liquid, stand-by；
C) miconazole nitrate 0.05-0.5g is weighed, is added in 0.4-2.3mL75% ethanol, standing allows it fully to dissolve,
Miconazole nitrate solution is obtained, it is stand-by；
D) urea 0.05-0.5g is weighed, is added in 2.0-5.0mL distilled water, 60-70 DEG C of heating water bath, in heating
Stirring, allows it fully to dissolve, obtains urea liquid, stand-by；
E) garlic extract 0.2-1.0mL, Radix Sophorae Flavescentis extractive liquid 0.3-1.5mL, lopseed extract solution 0.3- are measured respectively
1.6mL, Pericarpium Zanthoxyli extract 0.2-1.2mL, tuber of stemona extract solution 0.3-1.7mL, Folium Artemisiae Argyi extractive liquid 0.3-2.0mL, fruit of summer cypress extraction
Liquid 0.2-1.8mL and balsamine extract solution 0.3-1.5mL, is uniformly mixed, and obtains mixed liquor 1, stand-by；
F) azone 0.1-1.0g, glycerine 1.5-3.0g, aloe 0.2-1.0g and hippophae rhamnoides fruit oil 0.05- are weighed respectively
0.5g, stirring makes it uniformly mix, obtains mixed liquor 2, stand-by；
G) methyl hydroxybenzoate 0.01-0.08g and ethylparaben 0.01-0.08g are weighed respectively, add 75% ethanol
0.5-1.0mL stirrings make its dissolving, obtain antiseptic solution, stand-by；
H) it is HPMC coagulant liquid, sodium carboxymethylcellulose coagulant liquid, miconazole nitrate solution, urea is molten
Liquid, mixed liquor 1, mixed liquor 2 and antiseptic solution mixing, stir and evenly mix, add light-coloured vinegar 0.2-1.5mL, stir, produce and disappear
The gel of scorching antibacterial therapy onychomycosis.
The various composition of the present invention is as follows：
Miconazole nitrate category antifungal, the growth of most of fungi can be suppressed, to a variety of deep fungals (such as candida albicans,
Neogenesis cryptococcus, blastomycete etc.), some epidermis fungies and saccharomycete etc., be respectively provided with good antibacterial action.Gram positive bacteria
(such as staphylococcus, streptococcus) and bacillus (such as bacillus anthracis) also have the sensitiveness of height to it.Available for by fungi, yeast
Bacterium and other fungus-caused skins, refer to the infection of (toe) first.
Aloe includes natural colloidality material water conservation lignin, has strong infiltration, strong cleaning, antibacterial action, it may have disappear
Inflammation, detumescence, bacteria growing inhibiting, antipruritic, analgesic and other effects, while play and suppress skin surface pathogenic microorganisms and bacterium, kill
The acarid being extremely harmful to human body skin, the breeding of superficial microbes is prevented, prevent the generation of skin disease and onychomycosis.
Contain polyunsaturated fatty acid in hippophae rhamnoides fruit oil, sterol and natural vitamin etc. are a kind of with potent anti-
Virus, antibacterial, the natural antibacterial agent of bactericidal effect, under the powerful bactericidal effect of hippophae rhamnoides fruit oil, the harmful of onychomycosis can be caused
The chances of survival of microorganism is very little, so being frequently used in the making prescription of cosmetics and externally used antimicrobial medicine, is strengthened
Antibacterial effect.
Garlic contains the Fungicidal substances such as allicin, sulfide, to various pathogens such as staphylococcus, tubercle bacillus and cholera
Vibrios etc. has obvious suppress or the effect of strangling.The sulphur compound contained in garlic also has very strong antibacterial and anti-inflammation functions,
It is especially obvious for the inhibition of the pathogenic bacteria of onychomycosis.
Kuh-seng contains the compositions such as alkaloid, can effectively prevent bacterium infection, effectively suppresses the growth and breeding of bacterium, gives
A relatively sterile environment is built using a small range of position and its surrounding, plays a part of surface sterilization, to causing ash
It is " born jinx " for the Trichophyton rubrum of nail.Kuh-seng ether extract and alcohol extract have to staphylococcus aureus compared with
Strong bacteriostasis；Kuh-seng flooding agent has inhibitory action to Trichophyton concentricum, Trichophyton schoenleini etc..《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" treat skin
Skin itch, blood wind tinea sore, naughty white bits.”
Lopseed contains the compositions such as lignanoid, has anti-inflammatory, antibacterial and other effects.The leaf of lopseed is smashed to pieces, directly applied
The growth of surrounding bacterial can effectively be suppressed in skin surface, the sign if any bacterium infection also can obtain effective alleviation.This
The effect of medicine washout may also reach up analgesic antiphlogistic.
Chinese prickly ash energy heat-clearing and damp-drying drug is antipruritic, antibacterial, for various scall itch.Chinese prickly ash has antibacterial, analgesia, anesthesia and anticancer
Etc. a variety of pharmacological activity.Chinese prickly ash has the function that obvious antibacterial and sterilization to some dermatophytes, especially to some deeps
Fungi, have than more sensitive effect.The antimycotic experiment of alkaloid shows in Chinese prickly ash, it to yeast sample pathogenic bacteria and it is subcutaneous,
Bacteria skin infection has inhibitory action.
The tuber of stemona has certain therapeutic action to skin mange, eczema, to a variety of coccuses, bacillus, dermatophyte inhibitory action
Clearly.Tuber of stemona decoction, which is directly used in affected part, can improve rate of metabolism in the range of this, accelerate the new of this block tissue
It is raw, there is good facilitation for the later stage Restoration stage for treating onychomycosis.
Folium artemisiae argyi is a kind of extensive pedigree antibiotic, there is the effects such as antibacterial, enhancing immunologic function.Folium artemisiae argyi is to many viruses and bacterium
There are suppression and lethal effect.Folium artemisiae argyi decoct soup washout can also control wet sore mange, removing dampness to stop itchin.Part of the folium artemisiae argyi comburant to skin
Fungi has inhibitory action.Mother and baby's room air is carried out disinfection experiment using folium artemisiae argyi comburant fumigating system, it is to corynebacterium diphtheriae, tuberculosis
About 10 kinds of common germs such as bacillus, staphylococcus aureus have antibacterial or sterilization effect.
The fruit of summer cypress is usually used in treating malignant sore, the wet disease such as itch outside skin, can clearing away damp-heat, diuresis, anti-dermatophyte etc..
《Book on Chinese herbal medicine is original》：" accumulated heat in skin is gone, it is wet apart from skin to itch." present invention has degree different using flooding agent to dermatophyte
Inhibitory action.
Balsamine can be used for treating onychomycosis, play the role of very strong suppression fungi, can effectively kill and cause first fungi, long
It has been used to treat athlete's foot and onychomycosis inflammation etc. since long.Balsamine connects the work that leaf extract can substantially suppress bacterium and fungi
Property, its water decoction external application has anti-inflammatory, sterilization, convergence surface of a wound effect.Modern pharmacological research finds that balsamine has anti-dermatophyte
Effect, the different extracts of balsamine have inhibitory action to a variety of principal causative fungies for causing hand, sufficient onychomycosis disease.
Light-coloured vinegar has certain bactericidal ability and can dissolve excoriative horn cell.To Bacillus bacterium,
The vinegar such as Micrococcus bacterium and pathogenicity coliform can completely inhibit its breeding.Vinegar also has very strong to a variety of fungies such as tinea
Killing ability.《Do not record》：" subduing inflammation, aproll gas, pathogenic toxin killing.”
Urea can be used for treating onychomycosis, and long-term encapsulating, has very strong cutin release effect, while can press down in higher concentrations
The growth and breeding of tinea bacterium processed.
Azone has very strong transdermal effect to hydrophilic and lipophilic drugs, and being usually added into 0.2-2% can be by Transdermal absorption
Effect is multiplied, so as to strengthen the using effect of curative effect of medication and cosmetics, moreover it is possible to reduces the use of main ingredient and nutrients, drops
Low cost.Azone is used as bleeding agent in the present invention, and is smeared as external used medicine, the penetrating agent of massage.
HPMC is excellent gel-type vehicle, has thickening capabilities, pH stability, is wide variety of gel base
Matter.
Sodium carboxymethylcellulose has excellent water solubility, is commonly used for thickener, stabilizer, and nontoxic nonirritant.
Glycerine is a kind of excellent dynamic NMF, can discharge moisture according to the situation of surrounding tissue, be advantageous to medicine
Absorb.Glycerine can form one layer of natural diaphragm in affected part, can play the effect of the protection surface of a wound and can also reduce medicine
The loss of thing acts on sustained drug.
Compared with prior art, it is provided by the invention treatment onychomycosis gel from garlic, kuh-seng, lopseed, Chinese prickly ash,
Effective component extracting in the natural drugs such as the tuber of stemona, folium artemisiae argyi, the fruit of summer cypress, there is the effect of significant treatment onychomycosis, and can be extensive
Multiple patient's nail or the original profile of toe and function, also there are Small side effects, uneasy to recur etc. relative in the market similar drugs
Advantage.
Compared with prior art, it is of the invention by drug extract and the relatively good water-soluable gel discrete phase knot of absorbability
Close, there is splendid bactericidal effect, while onychomycosis is treated, patient's nail or the original profile of toe and function can be recovered,
Significantly improve the quality of life of patient.In addition, also there is anti-inflammatory, oxidation resistant effect, energy while onychomycosis is treated
Build the hand and foot environment of good health.
Embodiment
With reference to embodiment, the present invention will be further described.
Embodiment 1
A kind of gel of antiphlogistic antibacterial treatment onychomycosis, include the raw material components of following proportionings：
The preparation of 1.1 garlic extracts
Garlic 50g is weighed, is smashed to pieces, soaks 0.4h, heating and refluxing extraction 3 times：1st time plus 18 times amount water, extracts 1.0h；The
2 times plus 12 times amount water, extract 1.0h；3rd time plus 8 times amount water, extract 0.5h, filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration is filtered and produced to 3 times of g/mL of garlic quality.
The preparation of 1.2 Radix Sophorae Flavescentis extractive liquids
Kuh-seng coarse powder 45g is weighed, soaks 0.5h, heating and refluxing extraction 3 times：1st time plus 16 times 75% ethanol of amount, extraction
1.5h；2nd time plus 12 times 75% ethanol of amount, extracts 1.0h；3rd time plus 12 times 75% ethanol of amount, extracts 0.5h, filters every time
Filtrate, merging filtrate, 4 times of g/mL of kuh-seng quality are concentrated under reduced pressure into, filters and produces.
The preparation of 1.3 lopseed extract solutions
Lopseed 80g is weighed, is shredded, soaks 0.3h, heating and refluxing extraction 3 times：1st time plus 22 times amount water, extracts 1.0h；
2nd time plus 20 times amount water, extracts 1.0h；3rd time plus 18 times amount water, extracts 0.5h, filters to obtain filtrate, merging filtrate, filter every time
The volume concentration of liquid is filtered and produced to 3 times of g/mL of lopseed quality.
The preparation of 1.4 Pericarpium Zanthoxyli extracts
Weigh Chinese prickly ash coarse powder 40g, 75% ethanol immersion 0.3h, heating and refluxing extraction 3 times：1st time plus 12 times 75% second of amount
Alcohol, extract 1.0h；2nd time plus 10 times 75% ethanol of amount, extracts 1.0h；3rd time plus 8 times 75% ethanol of amount, extracts 0.5h, every time
Filtrate is filtered to obtain, merging filtrate, 2 times of g/mL of Chinese prickly ash quality is concentrated under reduced pressure into, filters and produce.
The preparation of 1.5 tuber of stemona extract solutions
Tuber of stemona coarse powder 50g is weighed, soaks 0.4h, heating and refluxing extraction 3 times：1st time plus 15 times amount water, extracts 1.5h；2nd
Secondary plus 13 times of amount water, extract 1.0h；3rd time plus 10 times amount water, extract 1.0h, filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration is filtered and produced to 4 times of g/mL of tuber of stemona quality.
The preparation of 1.6 Folium Artemisiae Argyi extractive liquids
Folium artemisiae argyi 70g is weighed, is shredded, soaks 0.5h, heating and refluxing extraction 3 times：1st time plus 18 times amount water, extracts 1.0h；The
2 times plus 15 times amount water, extract 1.0h；3rd time plus 8 times amount water, extract 0.5h, filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration is filtered and produced to 3 times of g/mL of folium artemisiae argyi quality.
The preparation of 1.7 fruit of summer cypress extract solutions
Fruit of summer cypress 45g is weighed, soaks 0.3h, heating and refluxing extraction 3 times：1st time plus 16 times amount water, extracts 1.5h；2nd time
Add 12 times of amount water, extract 1.0h；3rd time plus 8 times amount water, extracts 1.0h, filters to obtain filtrate, merging filtrate, the body of filtrate every time
Product is concentrated into 2 times of g/mL of summer cypress protonatomic mass, filters and produces.
The preparation of 1.8 balsamine extract solutions
Balsamine 55g is weighed, is shredded, soaks 0.4h, heating and refluxing extraction 3 times：1st time plus 18 times 75% ethanol of amount, is carried
Take 1.0h；2nd time plus 14 times 75% ethanol of amount, extracts 1.0h；3rd time plus 8 times 75% ethanol of amount, extracts 0.5h, every time filtration
Filtrate is obtained, merging filtrate, 6 times of g/mL for being concentrated into balsamine quality is evaporated under reduced pressure, filters and produce.
The preparation of the gel of 1.9 antiphlogistic antibacterials treatment onychomycosis
A) weigh HPMC 0.2g to be added in 20.0mL distilled water, stand overnight, it is fully swelled,
Dissolving, obtains HPMC coagulant liquid, stand-by；
B) sodium carboxymethylcellulose 0.1g is weighed, is added in 30.0mL distilled water, stands overnight, it is fully swelled,
Dissolving, obtains sodium carboxymethylcellulose coagulant liquid, stand-by；
C) miconazole nitrate 0.05g is weighed, is added in 0.4mL75% ethanol, standing allows it fully to dissolve, and obtains nitric acid miaow
Health azoles solution, it is stand-by；
D) urea 0.05g is weighed, is added in 2.0mL distilled water, 60 DEG C of heating water baths, heats while stirring, allows it to fill
Divide dissolving, obtain urea liquid, it is stand-by；
E) garlic extract 0.2mL, Radix Sophorae Flavescentis extractive liquid 0.3mL, lopseed extract solution 0.3mL, Chinese prickly ash extraction are measured respectively
Liquid 0.2mL, tuber of stemona extract solution 0.3mL, Folium Artemisiae Argyi extractive liquid 0.3mL, fruit of summer cypress extract solution 0.2mL and balsamine extract solution 0.3mL,
It is uniformly mixed, obtains mixed liquor 1, it is stand-by；
F) azone 0.1g, glycerine 1.5g, aloe 0.2g and hippophae rhamnoides fruit oil 0.05g are weighed respectively, are made with mixer stirring
It is uniformly mixed, and obtains mixed liquor 2, stand-by；
G) methyl hydroxybenzoate 0.01g and ethylparaben 0.01g are weighed respectively, and adding 75% ethanol 0.5mL stirrings makes
It dissolves, and obtains antiseptic solution, stand-by；
H) it is the HPMC coagulant liquid, sodium carboxymethylcellulose coagulant liquid, miconazole nitrate of above-mentioned preparation is molten
Liquid, urea liquid, mixed liquor 1, mixed liquor 2 and antiseptic solution mixing, stir and evenly mix, add light-coloured vinegar 0.2mL, stirred with mixer
Mix the gel for uniformly, producing antiphlogistic antibacterial treatment onychomycosis.
Embodiment 2
A kind of gel of antiphlogistic antibacterial treatment onychomycosis, include the raw material components of following proportionings：
2.1 the preparation of garlic extract
Garlic 40g is weighed, is smashed to pieces, soaks 0.6h, heating and refluxing extraction 3 times：1st time plus 18 times amount water, extracts 1.5h；The
2 times plus 16 times amount water, extract 1.5h；3rd time plus 10 times amount water, extracts 1.0h, filters to obtain filtrate, merging filtrate, filtrate every time
Volume concentration to 4 times of g/mL of garlic quality, filter and produce.
The preparation of 2.2 Radix Sophorae Flavescentis extractive liquids
Kuh-seng coarse powder 35g is weighed, soaks 0.8h, heating and refluxing extraction 3 times：1st time plus 16 times 75% ethanol of amount, extraction
1.5h；2nd time plus 12 times 75% ethanol of amount, extracts 1.5h；3rd time plus 12 times 75% ethanol of amount, extracts 1.0h, filters every time
Filtrate, merging filtrate, 5 times of g/mL of kuh-seng quality are concentrated under reduced pressure into, filters and produces.
2.3 the preparation of lopseed extract solution
Lopseed 30g is weighed, is shredded, soaks 0.5h, heating and refluxing extraction 3 times：1st time plus 24 times amount water, extracts 1.5h；
2nd time plus 20 times amount water, extracts 1.5h；3rd time plus 18 times amount water, extracts 1.0h, filters to obtain filtrate, merging filtrate, filter every time
The volume concentration of liquid is filtered and produced to 4 times of g/mL of lopseed quality.
The preparation of 2.4 Pericarpium Zanthoxyli extracts
Chinese prickly ash coarse powder 25g is weighed, soaks 0.5h, heating and refluxing extraction 3 times：1st time plus 14 times 75% ethanol of amount, extraction
1.5h；2nd time plus 12 times 75% ethanol of amount, extracts 1.5h；3rd time plus 10 times 75% ethanol of amount, extracts 1.0h, filters every time
Filtrate, merging filtrate, 4 times of g/mL of Chinese prickly ash quality are concentrated under reduced pressure into, filters and produces.
The preparation of 2.5 tuber of stemona extract solutions
Tuber of stemona coarse powder 40g is weighed, soaks 0.5h, heating and refluxing extraction 3 times：1st time plus 16 times amount water, extracts 1.5h；2nd
Secondary plus 14 times of amount water, extract 1.0h；3rd time plus 12 times amount water, extract 1.0h, filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration is filtered and produced to 5 times of g/mL of tuber of stemona quality.
The preparation of 2.6 Folium Artemisiae Argyi extractive liquids
Folium artemisiae argyi 65g is weighed, is shredded, soaks 0.6h, heating and refluxing extraction 3 times：1st time plus 20 times amount water, extracts 1.5h；The
2 times plus 16 times amount water, extract 1.5h；3rd time plus 12 times amount water, extracts 1.0h, filters to obtain filtrate, merging filtrate, filtrate every time
Volume concentration to 4 times of g/mL of folium artemisiae argyi quality, filter and produce.
The preparation of 2.7 fruit of summer cypress extract solutions
Fruit of summer cypress 60g is weighed, soaks 0.5h, heating and refluxing extraction 3 times：1st time plus 18 times amount water, extracts 2.0h；2nd time
Add 14 times of amount water, extract 1.5h；3rd time plus 10 times amount water, extracts 1.0h, filters to obtain filtrate, merging filtrate, the body of filtrate every time
Product is concentrated into 3 times of g/mL of summer cypress protonatomic mass, filters and produces.
The preparation of 2.8 balsamine extract solutions
Balsamine 55g is weighed, is shredded, soaks 0.5h, heating and refluxing extraction 3 times：1st time plus 20 times 75% ethanol of amount, is carried
Take 1.5h；2nd time plus 16 times 75% ethanol of amount, extracts 1.0h；3rd time plus 10 times 75% ethanol of amount, extracts 1.0h, every time filtration
Filtrate is obtained, merging filtrate, 7 times of g/mL for being concentrated into balsamine quality is evaporated under reduced pressure, filters and produce.
The preparation of the gel of 2.9 antiphlogistic antibacterials treatment onychomycosis
A) weigh HPMC 0.6g to be added in 30.0mL distilled water, stand overnight, it is fully swelled,
Dissolving, obtains HPMC coagulant liquid, stand-by；
B) sodium carboxymethylcellulose 0.5g is weighed, is added in 50.0mL distilled water, stands overnight, it is fully swelled,
Dissolving, obtains sodium carboxymethylcellulose coagulant liquid, stand-by；
C) miconazole nitrate 0.3g is weighed, is added in 2.0mL75% ethanol, standing allows it fully to dissolve, and obtains nitric acid miaow
Health azoles solution, it is stand-by；
D) urea 0.2g is weighed, is added in 3.0mL distilled water, 65 DEG C of heating water baths, heats while stirring, makes its abundant
Dissolving, obtains urea liquid, stand-by；
E) garlic extract 0.8mL, Radix Sophorae Flavescentis extractive liquid 0.6mL, lopseed extract solution 0.9mL, Chinese prickly ash extraction are measured respectively
Liquid 0.8mL, tuber of stemona extract solution 1.2mL, Folium Artemisiae Argyi extractive liquid 1.5mL, fruit of summer cypress extract solution 0.8mL and balsamine extract solution 1.0mL,
It is uniformly mixed, obtains mixed liquor 1, it is stand-by；
F) azone 0.5g, glycerine 2.0g, aloe 0.5g and hippophae rhamnoides fruit oil 0.3g are weighed respectively, make it with mixer stirring
Uniformly mixing, obtains mixed liquor 2, stand-by；
G) methyl hydroxybenzoate 0.04g and ethylparaben 0.02g are weighed respectively, and adding 75% ethanol 0.6mL stirrings makes
It dissolves, and obtains antiseptic solution, stand-by；
H) it is HPMC coagulant liquid, sodium carboxymethylcellulose coagulant liquid, miconazole nitrate solution, urea is molten
Liquid, mixed liquor 1, mixed liquor 2 and antiseptic solution mixing, stir and evenly mix, add light-coloured vinegar 1.0mL, stirred with mixer, i.e.,
Obtain the gel of antiphlogistic antibacterial treatment onychomycosis.
Embodiment 3
A kind of gel of antiphlogistic antibacterial treatment onychomycosis, include the raw material components of following proportionings：
The preparation of 3.1 garlic extracts
Garlic 40g is weighed, is smashed to pieces, soaks 0.8h, heating and refluxing extraction 3 times：1st time plus 20 times amount water, extracts 2.0h；The
2 times plus 18 times amount water, extract 2.0h；3rd time plus 12 times amount water, extracts 1.0h, filters to obtain filtrate, merging filtrate, filtrate every time
Volume concentration to 5 times of g/mL of garlic quality, filter and produce.
The preparation of 3.2 Radix Sophorae Flavescentis extractive liquids
Kuh-seng coarse powder 30g is weighed, soaks 1.0h, heating and refluxing extraction 3 times：1st time plus 18 times 75% ethanol of amount, extraction
2.0h；2nd time plus 14 times 75% ethanol of amount, extracts 1.5h；3rd time plus 12 times 75% ethanol of amount, extracts 1.0h, filters every time
Filtrate, merging filtrate, 6 times of g/mL of kuh-seng quality are concentrated under reduced pressure into, filters and produces.
The preparation of 3.3 lopseed extract solutions
Lopseed 75g is weighed, is shredded, soaks 0.6h, heating and refluxing extraction 3 times：1st time plus 25 times amount water, extracts 2.0h；
2nd time plus 22 times amount water, extracts 2.0h；3rd time plus 20 times amount water, extracts 1.0h, filters to obtain filtrate, merging filtrate, filter every time
The volume concentration of liquid is filtered and produced to 5 times of g/mL of lopseed quality.
The preparation of 3.4 Pericarpium Zanthoxyli extracts
Chinese prickly ash coarse powder 20g is weighed, soaks 0.9h, heating and refluxing extraction 3 times：1st time plus 16 times 75% ethanol of amount, extraction
2.0h；2nd time plus 12 times 75% ethanol of amount, extracts 1.5h；3rd time plus 10 times 75% ethanol of amount, extracts 1.0h, filters every time
Filtrate, merging filtrate, 6 times of g/mL of Chinese prickly ash quality are concentrated under reduced pressure into, filters and produces.
The preparation of 3.5 tuber of stemona extract solutions
Tuber of stemona coarse powder 50g is weighed, soaks 0.6h, heating and refluxing extraction 3 times：1st time plus 17 times amount water, extracts 2.0h；2nd
Secondary plus 15 times of amount water, extract 1.5h；3rd time plus 13 times amount water, extract 1.5h, filter to obtain filtrate every time, merging filtrate, filtrate
Volume concentration is filtered and produced to 7 times of g/mL of tuber of stemona quality.
The preparation of 3.6 Folium Artemisiae Argyi extractive liquids
Folium artemisiae argyi 85g is weighed, is shredded, soaks 0.8h, heating and refluxing extraction 3 times：1st time plus 20 times amount water, extracts 2.0h；The
2 times plus 18 times amount water, extract 1.5h；3rd time plus 15 times amount water, extracts 1.0h, filters to obtain filtrate, merging filtrate, filtrate every time
Volume concentration to 6 times of g/mL of folium artemisiae argyi quality, filter and produce.
The preparation of 3.7 fruit of summer cypress extract solutions
Fruit of summer cypress 50g is weighed, soaks 0.8h, heating and refluxing extraction 3 times：1st time plus 20 times amount water, extracts 2.5h；2nd time
Add 16 times of amount water, extract 1.5h；3rd time plus 12 times amount water, extracts 1.5h, filters to obtain filtrate, merging filtrate, the body of filtrate every time
Product is concentrated into 4 times of g/mL of summer cypress protonatomic mass, filters and produces.
The preparation of 3.8 balsamine extract solutions
Balsamine 80g is weighed, is shredded, soaks 0.6h, heating and refluxing extraction 3 times：1st time plus 20 times 75% ethanol of amount, is carried
Take 2.0h；2nd time plus 18 times 75% ethanol of amount, extracts 1.5h；3rd time plus 12 times 75% ethanol of amount, extracts 1.0h, every time filtration
Filtrate is obtained, merging filtrate, 8 times of g/mL for being concentrated into balsamine quality is evaporated under reduced pressure, filters and produce.
The preparation of the gel of 3.9 antiphlogistic antibacterials treatment onychomycosis
A) weigh HPMC 1.0g to be added in 35.0mL distilled water, stand overnight, it is fully swelled,
Dissolving, obtains HPMC coagulant liquid, stand-by；
B) sodium carboxymethylcellulose 1.0g is weighed, is added in 60.0mL distilled water, stands overnight, it is fully swelled,
Dissolving, obtains sodium carboxymethylcellulose coagulant liquid, stand-by；
C) miconazole nitrate 0.5g is weighed, is added in 2.3mL75% ethanol, standing allows it fully to dissolve, and obtains nitric acid miaow
Health azoles solution, it is stand-by；
D) urea 0.5g is weighed, is added in 5.0mL distilled water, 70 DEG C of heating water baths, heats while stirring, makes its abundant
Dissolving, obtains urea liquid, stand-by；
E) garlic extract 1.0mL, Radix Sophorae Flavescentis extractive liquid 1.5mL, lopseed extract solution 1.6mL, Chinese prickly ash extraction are measured respectively
Liquid 1.2mL, tuber of stemona extract solution 1.7mL, Folium Artemisiae Argyi extractive liquid 2.0mL, fruit of summer cypress extract solution 1.8mL, balsamine extract solution 1.5mL,
It is uniformly mixed, obtains mixed liquor 1, it is stand-by；
F) azone 1.0g, glycerine 3.0g, aloe 1.0g and hippophae rhamnoides fruit oil 0.5g are weighed respectively, make it with mixer stirring
Uniformly mixing, obtains mixed liquor 2, stand-by；
G) methyl hydroxybenzoate 0.08g and ethylparaben 0.08g are weighed respectively, and adding 75% ethanol 1.0mL stirrings makes
It dissolves, and obtains antiseptic solution, stand-by；
H) it is HPMC coagulant liquid, sodium carboxymethylcellulose coagulant liquid, miconazole nitrate solution, urea is molten
Liquid, mixed liquor 1, mixed liquor 2 and antiseptic solution mixing, stir and evenly mix, add light-coloured vinegar 1.5mL, stirred with mixer, i.e.,
Obtain the gel of antiphlogistic antibacterial treatment onychomycosis.
Embodiment 4
4.1 character
This product is that viscosity is suitable, it is fine and smooth uniformly, stretchability and the good gel of skin absorption.
4.2 pH value inspections
A small amount of gel, pH value 6-7 are dipped with the pH test paper of wetting.
4.3 caloric test
Gel is packaged in transparence cosmetic bottle, in 4 DEG C of refrigerator cold-storage observations in one week or so without lamination.In
24h in 55 DEG C of insulating box, it is no to be layered phenomena such as spoiled.
4.4 centrifugal test
Gel is packaged in 3000r/min in centrifuge tube and centrifuges 20min, no lamination.
4.5 irritation tests, anaphylaxis experiment
Small white mouse back cuts off hair, smears the gel prepared by embodiment 1,2,3 respectively in cutting plucked position, and not
Apply position to be compared, as a result without excitant and allergic reaction.
4.6 room temperatures place experiment
1,2,3 made gel of embodiment is placed in bottle for cosmetics, is stored at room temperature and investigates 6 months, no lamination,
Feel unchanged after, smell is unchanged.
Embodiment 5
The gel resultant effect is investigated
Following with probation the effect of feeling to evaluate gel that embodiment 1,2,3 produces.Commented using opinion poll
Point-score, 90 onychomycosis patients are chosen as object on probation, three groups is arbitrarily divided into, is prepared respectively with embodiment 1,2,3 solidifying
Jelly treats onychomycosis, uses 2 times, uses 3 weeks daily.Every using effect total score is 5 points：5 points are best result, are represented very
It is good, it is very satisfied；4 points are preferable；3 points are to receive；Less than 3 points are bad, it is impossible to are received.It is averaged below to be every
Point.It the results are shown in Table 1：
The resultant effect of table 1 is investigated
In summary, the made gel of the present invention absorbs fast, has good compliance, the preventing and treating curative effect to onychomycosis
Definitely, there is anti-inflammatory, antibacterial, the quality for improving nail and color and treatment tinea pedis and other effects, can obtain the onychomycosis of patient
Improve to obvious, immunity is effectively improved.
Claims (10)
- A kind of 1. gel of antiphlogistic antibacterial treatment onychomycosis, it is characterised in that the gel of the antiphlogistic antibacterial treatment onychomycosis Agent includes the raw material components of following proportionings：
- 2. the gel of antiphlogistic antibacterial treatment onychomycosis according to claim 1, it is characterised in that described garlic extract It is prepared by the following method：It is appropriate to weigh garlic, smashs to pieces, is soaked in water after 0.4-0.8h, heating and refluxing extraction 3 times：1st time plus 18-20 times measure water, Extract 1.0-2.0h；2nd time plus 12-18 times measure water, extract 1.0-2.0h；3rd time plus 8-12 times measure water, extract 0.5-1.0h, Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 3-5 times of g/mL of garlic quality.
- 3. the gel of antiphlogistic antibacterial treatment onychomycosis according to claim 1 or claim 2, it is characterised in that described kuh-seng carries Liquid is taken to be prepared by the following method：It is appropriate to weigh kuh-seng coarse powder, after adding the ethanol of volume fraction 75% immersion 0.5-1.0h, heating and refluxing extraction 3 times：1st time plus 16-18 times is measured 75% ethanol, extracts 1.5-2.0h；2nd time plus 12-14 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 12-14 times is measured 75% ethanol, extracts 0.5-1.0h, filters to obtain filtrate every time, merging filtrate, is concentrated under reduced pressure into the 4- of kuh-seng quality 6 times of g/mL, filter and produce.
- 4. the gel of onychomycosis is treated according to any one of the claim 1-3 antiphlogistic antibacterials, it is characterised in that described is saturating Bone grass extract solution is prepared by the following method：It is appropriate to weigh lopseed, shreds, after soaking 0.3-0.6h, heating and refluxing extraction 3 times：1st time plus 22-25 times are measured Water, extract 1.0-2.0h；2nd time plus 20-22 times measure water, extract 1.0-2.0h；3rd time plus 18-20 times measure water, extract 0.5- 1.0h, filters to obtain filtrate, merging filtrate every time, and the volume concentration of filtrate is filtered and produced to 3-5 times of g/mL of lopseed quality.
- 5. the gel of onychomycosis is treated according to any one of the claim 1-4 antiphlogistic antibacterials, it is characterised in that described flower Green pepper extract solution is prepared by the following method：It is appropriate to weigh Chinese prickly ash coarse powder, after adding 75% ethanol immersion 0.3-0.9h, heating and refluxing extraction 3 times：1st time plus 12-16 times 75% ethanol is measured, extracts 1.0-2.0h；2nd time plus 10-12 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 8-10 times are measured 75% ethanol, 0.5-1.0h is extracted, filters to obtain filtrate every time, merging filtrate, be concentrated under reduced pressure into 2-6 times of g/mL of Chinese prickly ash quality, Filter and produce.
- 6. the gel of onychomycosis is treated according to any one of the claim 1-5 antiphlogistic antibacterials, it is characterised in that described hundred Portion's extract solution is prepared by the following method：It is appropriate to weigh tuber of stemona coarse powder, soaks 0.4-0.6h, heating and refluxing extraction 3 times：1st time plus 15-17 times measure water, extract 1.5- 2.0h；2nd time plus 13-15 times measure water, extract 1.0-1.5h；3rd time plus 10-13 times measure water, extract 1.0-1.5h, every time filtration Filtrate, merging filtrate are obtained, the volume concentration of filtrate is filtered and produced to 4-7 times of g/mL of tuber of stemona quality.
- 7. the gel of onychomycosis is treated according to any one of the claim 1-6 antiphlogistic antibacterials, it is characterised in that described Chinese mugwort Leaf extract is prepared by the following method：It is appropriate to weigh folium artemisiae argyi, shreds, after soaking 0.5-0.8h, heating and refluxing extraction 3 times：1st time plus 18-20 times measure water, Extract 1.0-2.0h；2nd time plus 15-18 times measure water, extract 1.0-1.5h；3rd time plus 8-15 times measure water, extract 0.5-1.0h, Filtrate, merging filtrate are filtered to obtain every time, the volume concentration of filtrate is filtered and produced to 3-6 times of g/mL of folium artemisiae argyi quality.
- 8. the gel of onychomycosis is treated according to any one of the claim 1-7 antiphlogistic antibacterials, it is characterised in that described ground Skin extract solution is prepared by the following method：It is appropriate to weigh the fruit of summer cypress, soaks 0.2-0.8h, heating and refluxing extraction 3 times：1st time plus 16-20 times measure water, extract 1.5-2.5h；2nd time plus 12-16 times measure water, extract 1.0-1.5h；3rd time plus 8-12 times measure water, extract 1.0-1.5h, every time Filtrate, merging filtrate are filtered to obtain, the volume concentration of filtrate is filtered and produced to 2-4 times of g/mL of summer cypress protonatomic mass.
- 9. the gel of onychomycosis is treated according to any one of the claim 1-8 antiphlogistic antibacterials, it is characterised in that described phoenix Celestial being flower extract solution is prepared by the following method：It is appropriate to weigh balsamine, shreds, after adding 75% ethanol immersion 0.4-0.6h, heating and refluxing extraction 3 times：1st time plus 18-20 75% ethanol of amount again, extract 1.0-2.0h；2nd time plus 14-18 times measure 75% ethanol, extract 1.0-1.5h；3rd time plus 8-12 times 75% ethanol is measured, extracts 0.5-1.0h, filtrate is filtered to obtain every time, merging filtrate, is evaporated under reduced pressure the 6-8 for being concentrated into balsamine quality Times g/mL, filters and produces.
- 10. a kind of preparation method of the gel of any one of claim 1-9 antiphlogistic antibacterial treatment onychomycosis, its feature exist In the preparation method comprises the following steps：A) weigh HPMC 0.1-1.0g to be added in 20.0-35.0mL distilled water, stand overnight, make its abundant Swelling, dissolving, obtain HPMC coagulant liquid, stand-by；B) sodium carboxymethylcellulose 0.1-1.0g is weighed, is added in 30.0-60.0mL distilled water, stands overnight, makes its abundant Swelling, dissolving, obtain sodium carboxymethylcellulose coagulant liquid, stand-by；C) miconazole nitrate 0.05-0.5g is weighed, is added in 0.4-2.3mL75% ethanol, standing allows it fully to dissolve, and obtains nitre Sour Miconazole solution, it is stand-by；D) urea 0.05-0.5g is weighed, is added in 2.0-5.0mL distilled water, 60-70 DEG C of heating water bath, is heated while stirring, Allow it fully to dissolve, obtain urea liquid, it is stand-by；E) measure respectively garlic extract 0.2-1.0mL, Radix Sophorae Flavescentis extractive liquid 0.3-1.5mL, lopseed extract solution 0.3-1.6mL, Pericarpium Zanthoxyli extract 0.2-1.2mL, tuber of stemona extract solution 0.3-1.7mL, Folium Artemisiae Argyi extractive liquid 0.3-2.0mL, fruit of summer cypress extract solution 0.2- 1.8mL and balsamine extract solution 0.3-1.5mL, is uniformly mixed, and obtains mixed liquor 1, stand-by；F) azone 0.1-1.0g, glycerine 1.5-3.0g, aloe 0.2-1.0g and hippophae rhamnoides fruit oil 0.05-0.5g are weighed respectively, are stirred Mixing makes it uniformly mix, and obtains mixed liquor 2, stand-by；G) methyl hydroxybenzoate 0.01-0.08g and ethylparaben 0.01-0.08g are weighed respectively, add 75% ethanol 0.5- 1.0mL stirrings make its dissolving, obtain antiseptic solution, stand-by；H) by HPMC coagulant liquid, sodium carboxymethylcellulose coagulant liquid, miconazole nitrate solution, urea liquid, mixed Liquid 1, mixed liquor 2 and antiseptic solution mixing are closed, is stirred and evenly mixed, is added light-coloured vinegar 0.2-1.5mL, stir, produce anti-inflammatory and resist Bacterium treats the gel of onychomycosis.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110833574A (en) * | 2018-08-16 | 2020-02-25 | 安徽世龙生物医药科技有限公司 | External preparation and preparation method thereof |
| CN111658722A (en) * | 2020-06-22 | 2020-09-15 | 广东省微生物研究所（广东省微生物分析检测中心） | External traditional Chinese medicine lotion for preventing and treating onychomycosis and preparation method thereof |
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| CN114796338B (en) * | 2022-05-07 | 2023-11-03 | 绍兴百立康医疗科技有限公司 | Gel for treating onychomycosis and preparation method thereof |
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| CN1292268A (en) * | 2000-04-24 | 2001-04-25 | 缪振兴 | Medicine for curing tinea unguium |
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| CN110833574A (en) * | 2018-08-16 | 2020-02-25 | 安徽世龙生物医药科技有限公司 | External preparation and preparation method thereof |
| CN111658722A (en) * | 2020-06-22 | 2020-09-15 | 广东省微生物研究所（广东省微生物分析检测中心） | External traditional Chinese medicine lotion for preventing and treating onychomycosis and preparation method thereof |
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