CN111658722A

CN111658722A - External traditional Chinese medicine lotion for preventing and treating onychomycosis and preparation method thereof

Info

Publication number: CN111658722A
Application number: CN202010573256.7A
Authority: CN
Inventors: 彭红; 周刚; 王颖思; 施庆珊; 谢小保
Original assignee: Guangdong Detection Center of Microbiology of Guangdong Institute of Microbiology
Current assignee: Guangdong Detection Center of Microbiology of Guangdong Institute of Microbiology
Priority date: 2020-06-22
Filing date: 2020-06-22
Publication date: 2020-09-15
Anticipated expiration: 2040-06-22
Also published as: CN111658722B

Abstract

The invention discloses an external traditional Chinese medicine lotion for preventing and treating onychomycosis and a preparation method thereof. The composition comprises the following raw materials in parts by weight: 20-30 parts of propolis, 15-20 parts of szechwan chinaberry, 20-25 parts of garden balsam, 20-30 parts of Chinese violet, 15-30 parts of camphor leaf, 20-30 parts of radix sophorae flavescentis, 20-25 parts of pericarpium zanthoxyli, 20-30 parts of alum, 20-25 parts of aloe, 20-30 parts of schizonepeta, 20-30 parts of wormwood, 10-20 parts of scutellaria baicalensis, 1000-1500 parts of ethanol with the volume fraction of 75%, and 1000-1500 parts of white vinegar. The external traditional Chinese medicine lotion for preventing and treating onychomycosis can soften and remove diseased nails, is beneficial to directly reaching focus, treats both principal and secondary aspect of disease, eliminates clinical manifestation, finally achieves the aim of healing, and has good treatment effect and difficult recurrence.

Description

External traditional Chinese medicine lotion for preventing and treating onychomycosis and preparation method thereof

Technical Field

The invention relates to the technical field of natural medicines, in particular to an external traditional Chinese medicine lotion for preventing and treating onychomycosis caused by fungal infection and a preparation method thereof.

Background

Onychomycosis is commonly called as onychomycosis, and clinically manifested as turbid diseased nails, onychomycosis, uneven nail surface, discoloration, thickening, brittleness, fragility and the like. Onychomycosis is usually caused by trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum, filamentous fungi, sporophytes, fusarium and other fungi, and is mostly expressed on the nail or toenail with malnutrition, and the common conditions are as follows: the disease damage is limited to one piece of the nail surface or the tip of the nail surface; the disease is characterized by comprising the following components of a distal lateral position type, a proximal subungual type and a superficial white type, wherein the disease starts from two sides or the distal end of the nail, and then the infection occurs below the nail plate; (3) endophytic fungi, which do not show hypokeratosis or nail separation, cross the cuticle of the nail and form milky patches. Onychomycosis is a fungal disease of nails caused by infection of fungi, and can cause dermatophytosis by being transmitted to the skin, the two diseases are not directly continuous, but if the onychomycosis disease is not treated in time or is not completely treated, the skin can be infected with the fungi, and the onychomycosis is easily caused.

Onychomycosis has strong infectivity, and the disease can bring great harm to the health of people, so that in daily life, if the onychomycosis condition is found, the onychomycosis can be prevented from contacting with other people as much as possible, and people do not need to share toiletries with other people, so that the infection to other people is avoided. Patients suffering from onychomycosis should be treated as soon as possible.

The terbinafine or itraconazole is usually orally taken for treating onychomycosis, the medicine is relatively good in safety on the whole, but due to the particularity of the onychomycosis and the nail plate, the treatment lasts for a long time, the growth cycle of a new nail generally needs 2-3 months, the medicine is taken according to the growth cycle of the nail or toenail, the medicine for the nail needs 2 months, and the medicine for the toenail needs 3 months. In actual clinical treatment, if the prevention is not paid attention to, the self is repeatedly infected or the self is cross-infected with other people, the treatment time can far exceed the growth cycle of the nail, and the medication even needs about half a year to 1 year. In 2002 the U.S. food and drug administration warns of the risk of serious adverse drug reactions associated with terbinafine or itraconazole, which may lead to severe liver function impairment, liver failure and even death, and also with itraconazole which may cause congestive heart failure.

The invention content is as follows:

the invention aims to provide an external traditional Chinese medicine lotion for preventing and treating onychomycosis, which can soften and remove diseased nails, is beneficial to directly reaching focus, treats both principal and secondary aspects of disease, eliminates clinical manifestations, finally achieves the aim of curing, and has good treatment effect and difficult recurrence.

The external traditional Chinese medicine lotion for preventing and treating onychomycosis is characterized by comprising the following raw materials in parts by weight: 20-30 parts of propolis, 15-20 parts of szechwan chinaberry, 20-25 parts of garden balsam, 20-30 parts of Chinese violet, 15-30 parts of camphor leaf, 20-30 parts of radix sophorae flavescentis, 20-25 parts of pericarpium zanthoxyli, 20-30 parts of alum, 20-25 parts of aloe, 20-30 parts of schizonepeta, 20-30 parts of wormwood, 10-20 parts of scutellaria baicalensis, 1000-1500 parts of ethanol with the volume fraction of 75%, and 1000-1500 parts of white vinegar.

The second purpose of the invention is to provide a preparation method of an external traditional Chinese medicine lotion for preventing and treating onychomycosis, which comprises the following steps:

a. drying 12 medicaments of propolis, szechwan chinaberry, garden balsam, Chinese violet, camphor leaf, lightyellow sophora root, pericarpium zanthoxyli, alum, aloe, fineleaf schizonepeta herb, wormwood and baical skullcap root according to the weight ratio of the formula, crushing, sieving by using 200 meshes of fine powder;

b. adding 75% ethanol to wet the fine powder, loading into percolation tank, soaking in 75% ethanol, extracting, and percolating slowly to obtain filtrate;

c. adding white vinegar with the same volume as the filtrate, and performing ultrasonic treatment to obtain the external traditional Chinese medicine lotion for preventing and treating onychomycosis.

Preferably, the step b is: wetting the fine powder with 75% ethanol for 5 hr, loading into infiltration tank, soaking in 75% ethanol for 48 hr, and slowly percolating to obtain filtrate;

preferably, the ultrasound is ultrasonic for 30min at room temperature by using an ultrasonic instrument (frequency 40kHz, power 100W).

The application method of the external traditional Chinese medicine lotion for preventing and treating onychomycosis of the invention comprises the following steps:

taking 150-200 mL (1500-2000 mL for foot bath) of diseased nails each time for 20-30 min, softening and separating diseased nails, scraping the aerial loose parts of diseased nails as much as possible with a nail clipper, 1 time each in the morning and evening, insisting on treatment for 12 weeks, and observing the curative effect.

Evaluation criteria of therapeutic effect (refer to Xuezanfeng, Huyanjun, xudongping. Compound onychomycosis remedy onychomycosis clinical observation [ J ]. Chinese J. dermatosis, 2012, 26 (12): 1131 + 1132.)

And (3) healing: the diseased nail is completely faded, the nail plate becomes smooth, the smooth color is bright, and the fungus microscopy is negative; the effect is shown: the disease A fades to be more than or equal to 60 percent, and fungus microscopy is negative or a small amount of broken or deformed hypha and spores can be seen; the method has the following advantages: the regression of diseased nails is more than or equal to 30 percent, and the fungus is positive by microscopic examination; and (4) invalidation: the regression of diseased nails is less than 30 percent, and the fungal microscopic examination is positive.

The pharmacological actions of the Chinese medicinal materials are as follows:

propolis: has effects in caring skin, promoting granulation, relieving inflammation, and relieving pain, and can be used for treating gastric ulcer, oral ulcer, burn, scald, skin pain, and radiation protection.

Toosendan fruit: clear heat, dry dampness and kill parasites, and can be used for treating ascaris, pinworm, rubella and scabies.

Impatiens balsamina L: promoting blood circulation for removing blood stasis, inducing diuresis for removing toxic substances, dredging channels and penetrating bone. Pounding for external use can be used for treating sore, furuncle, swelling and pain, and insect bite.

Herba Violae: clear heat and remove toxicity, cool blood and relieve swelling. Can be used for treating jaundice, dysentery, mastitis, conjunctival congestion, swelling and pain, and pharyngitis; it is indicated for traumatic injury, carbuncle, swelling, snake bite, etc. by external application.

Camphor leaf: dispelling pathogenic wind, removing dampness, relieving pain, and killing parasite, and can be used for treating rheumatalgia, traumatic injury, and scabies.

Flavescent sophora root: clear heat, dry dampness and kill parasites. It is used to treat dysentery due to heat and blood, intestinal wind, jaundice, leucorrhea with red and white discharge, infantile pneumonia, malnutritional stagnation, acute tonsillitis, anal fistula, rectocele, skin pruritus, scabies, malignant sore, eczema and pruritus vulvae, scrofula, and scald. It can be used for treating fungal infection and inflammation.

Pericarpium zanthoxyli: the zanthoxylum bungeanum belongs to traditional Chinese medicines, and has the effects of removing dampness, relieving pain and killing insects. Can be used for treating food retention, abdominal psychroalgia, emesis, anemofrigid-damp arthralgia, odontalgia, ascariasis, enterobiasis, scabies, etc.

Alum: detoxicating, killing parasite, eliminating dampness, relieving itching, stopping bleeding, relieving diarrhea, clearing heat, eliminating phlegm, and resisting trichomonas vaginalis.

Aloe vera: sterilizing, antiinflammatory, tonifying heart, promoting blood circulation, improving immunity, promoting regeneration, resisting tumor, removing toxic substances, resisting aging, and protecting against sunburn. Purgation, liver heat clearing and fire purging, and can be used for treating constipation due to heat accumulation, convulsive epilepsy, convulsion, and tinea and sore.

Herba schizonepetae: relieve exterior syndrome, dispel wind, promote eruption, eliminate sores and stop bleeding. Can be used for treating eye itching, cough, sore throat, measles, carbuncle, scabies, epistaxis, and pyocutaneous disease.

And (3) moxa: has antibacterial and antiviral effects, and can be used for treating folliculitis and eczema.

Scutellaria baicalensis: can be used for treating damp-warm disease, summer-heat dampness, chest distress, emesis, dampness-heat distention and fullness, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, blood heat, hematemesis, carbuncle, swelling, and sore.

The external traditional Chinese medicine lotion for preventing and treating onychomycosis can soften and remove diseased nails, is beneficial to directly reaching focus, treats both principal and secondary aspect of disease, eliminates clinical manifestation, finally achieves the aim of healing, and has good treatment effect and difficult recurrence.

The specific implementation mode is as follows:

the following examples are further illustrative of the present invention and are not intended to be limiting thereof.

Example 1

A traditional Chinese medicine lotion for external use for preventing and treating onychomycosis is composed of the following raw materials in parts by weight: 20 parts of propolis, 18 parts of szechwan chinaberry, 20 parts of impatiens balsamina, 20 parts of Chinese violet, 15 parts of camphor leaves, 20 parts of lightyellow sophora root, 20 parts of pericarpium zanthoxyli, 20 parts of alum, 20 parts of aloe, 20 parts of fineleaf schizonepeta herb, 20 parts of wormwood, 10 parts of baical skullcap root, 1000 parts of ethanol aqueous solution with volume fraction of 75%, and 1000 parts of white vinegar.

The preparation method comprises the following steps:

1. drying 12 medicaments of propolis, szechwan chinaberry, garden balsam, Chinese violet, camphor leaf, lightyellow sophora root, pericarpium zanthoxyli, alum, aloe, fineleaf schizonepeta herb, wormwood and baical skullcap root according to the weight ratio of the formula, crushing, sieving by using 200 meshes of fine powder;

2. adding 75% ethanol water solution by volume fraction to wet the fine powder for 5h, putting into an infiltration tank, and soaking and extracting with 75% ethanol water solution by volume fraction for 48 h.

3. Slowly percolating, and collecting filtrate.

4. Adding white vinegar with the same volume as the filtrate, ultrasonically treating at room temperature with ultrasonic instrument (frequency 40kHz, power 100W) for 30min, and packaging to obtain the final product, topical Chinese medicinal lotion for preventing and treating onychomycosis.

The using method comprises the following steps: taking 150-200 mL (1500-2000 mL for foot bath) of the diseased nail for 20-30 min each time, softening and separating the diseased nail, scraping the aerial pine part of the diseased nail as much as possible by a nail clipper, taking 1 time in the morning and evening each day, insisting on treatment for 12 weeks, and observing the curative effect.

Example 2

A traditional Chinese medicine lotion for external use for preventing and treating onychomycosis is composed of the following raw materials in parts by weight: 22 parts of propolis, 15 parts of szechwan chinaberry, 23 parts of garden balsam, 25 parts of Chinese violet, 20 parts of camphor leaf, 25 parts of radix sophorae flavescentis, 23 parts of pericarpium zanthoxyli, 26 parts of alum, 23 parts of aloe, 25 parts of herba schizonepetae, 23 parts of wormwood, 15 parts of scutellaria baicalensis, 1200 parts of ethanol aqueous solution with volume fraction of 75%, and 1200 parts of white vinegar.

The preparation method comprises the following steps:

3. Slowly percolating, and collecting filtrate.

Example 3

An external traditional Chinese medicine lotion for preventing and treating onychomycosis is characterized by comprising the following raw materials in parts by weight: 30 parts of propolis, 20 parts of szechwan chinaberry, 25 parts of garden balsam, 30 parts of Chinese violet, 30 parts of camphor leaf, 30 parts of radix sophorae flavescentis, 25 parts of pericarpium zanthoxyli, 30 parts of alum, 25 parts of aloe, 30 parts of herba schizonepetae, 30 parts of wormwood, 20 parts of scutellaria baicalensis, 1500 parts of ethanol aqueous solution with volume fraction of 75%, and 1500 parts of white vinegar.

The preparation method comprises the following steps:

3. Slowly percolating, and collecting filtrate.

Typical case

The diagnosis standard for case selection was as follows, in reference to "Andelus clinical dermatology", Mejemes (James. WD) & Andelus clinical dermatology [ M ]. Beijing: science Press, 2004: 295-.

1. The superficial portion of the white nail plate was invaded and white spots appeared. The posterior deck becomes soft and sags, impairing the spread forward or around.

2. Invasive onychomycosis begins at the free edge or side wall of the nail, sometimes with very mild paronychia, and thus many minor depressions or transverse grooves appear in the nail plate. The nail plate is brittle, fragile, thickened and easy to break, and is yellow, yellow brown to black.

3. Laboratory examination, the fungus silk is visible under the microscope, and the fungus culture and the microscope examination are mostly positive.

The external traditional Chinese medicine lotion for preventing and treating onychomycosis of the embodiment 1:

the externally applied traditional Chinese medicine lotion for preventing and treating onychomycosis of example 1 is used for a yellow woman, a plurality of pits or transverse grooves of nails appear on the little toe of the right foot, and yellowish-brown nails, 1500-2000 mL of diseased nails are taken each time for 20-30 min, the diseased nails are softened and separated, the loose parts of the diseased nails are scraped as much as possible by a nail clipper, the disease nails are used 1 time in the morning and evening each day, the disease nails are used for 3 months after insisting, the symptoms disappear completely after three months, and the disease nails do not relapse at present after follow-up.

Mr. Li and onychomycosis also accompany beriberi for more years, beginning in 6 months 2019, 150-200 mL of vesicular disease nails are taken for 20-30 min every day according to example 1, and are taken for soaking feet in 1500-2000 mL of footbath of example 1 in the morning and evening, and the feet are taken for insisting every night. The symptom completely disappears after insisting on using for 3 months, and the follow-up does not relapse.

The left big toenail slowly thickens and turns white in 2018 for 10 months for old women, the affected part feels slightly painful when the toenail touches in 2019 in spring, the pain becomes worse in 2019 in 6 months, 150-200 mL of the disease-soaked toenail is taken every time for 20-30 min, the disease-soaked toenail is taken 1 time in the morning and at night every day, most of the thick and white toenail can be repaired after half a month, the small section close to the toenail root can be repaired after the nail is adhered for one month, the pain is relieved, the new toenail grows after two months, and the nail is completely cured after three months until no recurrence occurs today.

The external traditional Chinese medicine lotion for preventing and treating onychomycosis of the embodiment 2:

mr. Liangjia, the left thumb of the patient with the disease A for many years is crisp, thickened and black, and the disease A has a certain curative effect after being smeared with various ointments and liquid medicines, but the disease A recurs in one stage, the disease A is infected with the left food nail at present, three pits appear on the nail plate, and the fungus is positive in microscopic examination. The external traditional Chinese medicine lotion for preventing and treating onychomycosis in example 2 is used, 150-200 mL of diseased nails are taken each time for 20-30 min, the diseased nails are softened and separated, the hollow loose parts of the diseased nails are scraped as much as possible by a nail clipper, the diseased nails are used 1 time in the morning and evening each day for 2 months, after two months, the diseased nails are healed with the left index finger nail, the nail plate becomes smooth, the flat color and luster are bright, and the mycoscope examination is negative; the left-hand thumb nail has obvious effect, the diseased nail fades by 70 percent, a small amount of broken or deformed hypha and spore are observed by the fungus microscopic examination, and the fungus microscopic examination is negative, the nail plate becomes smooth, flat and bright after the left-hand thumb nail is continuously used for one month.

The three toes, the secondary little toe and the little toe of the left foot of a woman are suffered from paronychia for years, the three toes are red, swollen and hot and painful all the year round, the skin color near the three toes are dark, and the toenails are high and convex and are separated from the nail bed below the toenails. The external traditional Chinese medicine lotion for preventing and treating onychomycosis of the embodiment 2 is used, 1500-2000 mL of footbath is taken each time, and the diseased onychomycosis is soaked for 20-30 min and persists every night. The symptom completely disappears after insisting on using for three months, and the follow-up does not relapse.

Irregular small white spots appear on the side edge of the nail of the thumb of the right foot of the Liu female, the side edge becomes dull gray spots after one month, the side edge gradually becomes yellow brown to black, the nail plate deteriorates, the inferior cuticle fragments are accumulated, the nail bed is thickened, the nail plate becomes atrophied, and bleeding occasionally occurs. The external traditional Chinese medicine lotion for preventing and treating onychomycosis of the embodiment 2 is used, 1500-2000 mL of the tinea unguium in the footbath is taken for 20-30 min each time, and the lotion is maintained every night. The symptom completely disappears after the patient insists on using the medicine for half a year, and the disease does not relapse until the patient follows up.

The external traditional Chinese medicine lotion for preventing and treating onychomycosis of embodiment 3:

plum women, the little toe and the second little toe of the right foot are sunken, thickened and spread forwards or around, and are partially broken, yellowish in color and positive in mycoscopy. The external traditional Chinese medicine lotion for preventing and treating onychomycosis in example 3 is used, 1500-2000 mL of lotion is taken each time to soak the diseased nail for 20-30 min, the diseased nail is softened and separated, the hollow loose part of the diseased nail is scraped as much as possible by a nail clipper, the lotion is used 1 time in the morning and evening each day for 3 months, after three months, the effect is obvious, the symptom completely disappears, the diseased nail is completely faded, the nail plate is smooth and flat, the luster is bright, the recovery is realized, and the negative effect of fungal microscopy is realized.

Mr. forest, the surface of the middle crescent-shaped area of the right index finger plate has a small turbid area with an irregular point shape, and the nail surface is dark brown, which lasts for many years. The external traditional Chinese medicine lotion for preventing and treating onychomycosis in example 3 is used, 150-200 mL of the onychomycosis is taken each time for 20-30 min, and the onychomycosis heals after lasting use for three months.

Mr. Wang, beriberi is serious, toe seams have symptoms such as rottenness, water eruption and the like, the surfaces of the left big toe and the two toes of the right foot are black, scraps of inferior horns accumulate, diseased nails are crisp and easy to scrape, and trichophyton gypseum and fusarium are detected by a diseased nail microscope. By using the external traditional Chinese medicine lotion for preventing and treating onychomycosis of the embodiment 3, 1500-2000 mL of lotion is taken each time to soak the diseased nails for 20-30 min, 1 time is taken in the morning and at the evening each time, after the lotion is continuously used for 3 months, the diseased nails regress by 80%, and a small amount of broken or deformed hypha and spores can be seen through microscopic examination. And the beriberi symptoms disappear completely, the diseased nail disappears completely, the nail plate is smooth and flat, the gloss is bright, the disease is healed, and the mycoscope examination is negative after the treatment for one month.

In the treatment observation of the above cases, no adverse reaction occurs, and the treatment patient has obvious yellow stain on the first and second weeks, and the yellow stain is improved after the treatment is finished for 3 weeks by considering the dyeing effect of the traditional Chinese medicine. All patients insist on treatment until the treatment course is finished, and the patients who are not cured continue to be treated for one month, so that the symptoms completely disappear.

The invention is described in detail herein. Any obvious changes and modifications to the invention, by those skilled in the art, without departing from the principles of the invention, will fall within the scope of the appended claims.

Claims

1. An external traditional Chinese medicine lotion for preventing and treating onychomycosis is characterized by comprising the following raw materials in parts by weight: 20-30 parts of propolis, 15-20 parts of szechwan chinaberry, 20-25 parts of garden balsam, 20-30 parts of Chinese violet, 15-30 parts of camphor leaf, 20-30 parts of radix sophorae flavescentis, 20-25 parts of pericarpium zanthoxyli, 20-30 parts of alum, 20-25 parts of aloe, 20-30 parts of schizonepeta, 20-30 parts of wormwood, 10-20 parts of scutellaria baicalensis, 1000-1500 parts of ethanol with the volume fraction of 75%, and 1000-1500 parts of white vinegar.

2. A preparation method of the external traditional Chinese medicine lotion for preventing and treating onychomycosis as claimed in claim 1, which is characterized by comprising the following steps: a. drying 12 medicaments of propolis, szechwan chinaberry, garden balsam, Chinese violet, camphor leaf, lightyellow sophora root, pericarpium zanthoxyli, alum, aloe, fineleaf schizonepeta herb, wormwood and baical skullcap root according to the weight ratio of the formula, crushing, sieving by using 200 meshes of fine powder; b. adding 75% ethanol to wet the fine powder, loading into percolation tank, soaking in 75% ethanol, extracting, and percolating slowly to obtain filtrate; c. adding white vinegar with the same volume as the filtrate, and performing ultrasonic treatment to obtain the external traditional Chinese medicine lotion for preventing and treating onychomycosis.

3. The method according to claim 2, wherein the step b is: wetting the fine powder with 75% ethanol for 5 hr, loading into infiltration tank, soaking in 75% ethanol for 48 hr, and slowly percolating to obtain filtrate.

4. The preparation method according to claim 2, wherein the ultrasound is ultrasonic ultrasound with a frequency of 40kHz and a power of 100W for 30min at room temperature by using an ultrasonic instrument.