CN106109534A - The antipruritic repair liquid of silver ion antibacterial, preparation method and application - Google Patents

The antipruritic repair liquid of silver ion antibacterial, preparation method and application Download PDF

Info

Publication number
CN106109534A
CN106109534A CN201610707326.7A CN201610707326A CN106109534A CN 106109534 A CN106109534 A CN 106109534A CN 201610707326 A CN201610707326 A CN 201610707326A CN 106109534 A CN106109534 A CN 106109534A
Authority
CN
China
Prior art keywords
extract
antipruritic
repair liquid
silver ion
silver
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201610707326.7A
Other languages
Chinese (zh)
Other versions
CN106109534B (en
Inventor
叶符材
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangzhou Jiekang Pharmaceutical Technology Co., Ltd
Original Assignee
Guangzhou Cleaning Sanitary Articles Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangzhou Cleaning Sanitary Articles Co Ltd filed Critical Guangzhou Cleaning Sanitary Articles Co Ltd
Priority to CN201610707326.7A priority Critical patent/CN106109534B/en
Publication of CN106109534A publication Critical patent/CN106109534A/en
Application granted granted Critical
Publication of CN106109534B publication Critical patent/CN106109534B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus

Abstract

The present invention relates to pharmaceutical technology field, particularly relating to the antipruritic repair liquid of a kind of silver ion antibacterial, it includes following components by mass percentage: glycerol 2 10%, propylene glycol 3 10%, medicinal and edible plant extract 0.4 36%, remaining is silver ion antimicrobial agent and water；Wherein, the consumption of silver ion antimicrobial agent is so that in antipruritic repair liquid, silver ion content is the consumption of 1 5ppm；Described medicinal and edible plant extract includes one or more in Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Herba portulacae extract, Herba Centellae extract, Folium Menthae extract, Aloe extract, and any one medicinal and edible plant extract accounts for the mass percent of antipruritic repair liquid below 6%.The antipruritic repair liquid of the present invention, gentle, safe efficient, multiple-effect, wide spectrum.

Description

The antipruritic repair liquid of silver ion antibacterial, preparation method and application
Technical field
The present invention relates to pharmaceutical technology field, particularly relate to a kind of sterilizing and itch-relieving repair liquid, preparation method and application.
Background technology
Researcher is according to sterilization purpose and the feature of sterilization objects both at home and abroad, has carried out screening widely to antibacterial, but The most do not find a kind of preferably antibacterial.Aldehydes, acids antibacterial (formaldehyde, benzoic acid), its fungicidal spectrum is wide, but toxicity Greatly, corrosivity is strong, big to oral mucosa, skin irritation；Chlorinated product (triclosan, chlorhexidine acetate, chlorine dioxide, hypochlorous acid) Valid density is low, speed of action is fast, stable in properties, but is easily affected by Organic substance, acid, alkali and other physics, chemical factor, right Oral mucosa, skin irritation are the biggest.
Therefore, inorganic antiseptic enters the sight line of people.Researcher finds antimicrobial efficiency and its surface area relationship of silver Greatly, antibacterial effect can be improved by increase surface area.Sterilizing ability under nm regime can produce qualitative leap, only uses pole A small amount of nanometer silver just can produce the bactericidal action of strength.In recent years, nano silver powder had penetrated into such as water purification filter material, antibacterial Coating, series of amenities, anti-bacterial fibre cloth cleaning agent serial, all kinds of series, novel antibacterial application series etc. field.
But, production and the use of present nanometer silver are restricted, the U.S., Sweden, Japan, Germany, Australia Deng Guo environmental administration and chlorenchyma worry that environment and human body are brought harmful effect by nanometer silver wrappage carrier, the bag of nanometer silver Safety issue rather than the silver of wrapping up in the health problem affecting environment and the people substantially nanotechnology that thing may bring are antibacterial The problem of agent itself.Along with environmental protection department limits reinforcement and the uneasiness of user to nanometer silver, nanometer silver product may Receive a deadly blow.The product development of silver antibacterial agent will seek new outlet.
Moreover, existing formula technique either uses traditional aldehydes acids antibacterial (formaldehyde, benzoic acid), chlorine system Agent (triclosan, chlorhexidine acetate, chlorine dioxide, hypochlorous acid), or relatively new nano silver antimicrobials, collargol antibacterial All there is the defect of the undesirable and stability of antibacterial effect the most bad (variable color, acidity change) own.
It addition, in prior art, skin, oral mucosa restoration care composition use some western medicine compositions such as nicotinoyl mostly Amine, chlorphenamine, lignocaine etc. are bigger to skin, oral mucosa zest；Also some non-integration of edible and medicinal herbs Chinese herbal medicine can be added Dividing such as Radix Scutellariae, iron sheet stone bucket, Radix Sophorae Flavescentis, Fructus Cnidii, the Radix Stemonae, Cortex Phellodendri etc., these also have certain stimulation to skin, oral mucosa Property.In addition, even if skin, oral mucosa restoration care composition select interpolation zest little in prior art restoration care liquid Medicinal herb components, also add is extracts of Chinese herbal medicine, and effective ingredient consumption is fewer, and restoration care effect is not ideal. And integration of edible and medicinal herbs medicinal herb components powder, usually it is directly used in and swallows in medicine, directly act on affected part feelings for medicine for external use Condition but rarely has report.
Find some safety efficient, gentle, it might even be possible to oral medicinal and edible plant high concentration extract as skin, Oral cavity, cell migration nursing composition, be our direction of making great efforts.
Summary of the invention
In order to solve above technical problem, the present invention provide a kind of efficiently, gentleness safely, can be used in skin, vagina glues Film and intraoral antipruritic repair liquid.
In order to realize the technique effect of the present invention, have employed techniques below scheme and be achieved:
A kind of antipruritic repair liquid of silver ion antibacterial, the following components including by mass percentage: glycerol 2- 10%, propylene glycol 3-10%, medicinal and edible plant extract 0.4-36%, remaining is silver ion antimicrobial agent and water；Wherein, silver from The consumption of sub-antibacterial is so that in antipruritic repair liquid, concentration of silver ions is the consumption of 1-5ppm, i.e. repairs silver ion in liquor Mass fraction is 1-5ppm；Described medicinal and edible plant extract includes that Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Herba Portulacae carry Taking one or more in thing, Herba Centellae extract, Folium Menthae extract, Aloe extract, any one medicinal and edible plant carries Take thing and account for the mass percent of antipruritic repair liquid gross mass below 6%.
Silver ion antimicrobial agent is generally silver ionized water solution antibacterial, and silver ion is directly present in aqueous solution.
Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Herba portulacae extract, Herba Centellae extract, Folium Menthae extract, Aloe carry Taking thing can be commercially the corresponding dried powdered substance of various extracting solution.Described silver ion antimicrobial agent is also Can buy with import.
As further improving, described antipruritic repair liquid also includes the gold thread accounting for antipruritic repair liquid gross mass less than 6% Prunus mume extract and the Alumen accounting for antipruritic repair liquid gross mass less than 8%.
As further improving, described antipruritic repair liquid includes following components by mass percentage: glycerol 10%, Propylene glycol 10%, Flos Lonicerae extract 6%, Flos Chrysanthemi Indici extract 6%, Herba portulacae extract 6%, Herba Centellae extract 6% is thin Lotus extract 6%, Aloe extract 6%, remaining is silver ion antimicrobial agent and water；Wherein, the consumption of silver ion antimicrobial agent is for making Obtaining silver ion mass content in antipruritic repair liquid is the consumption of 5ppm.
As further improving, described antipruritic repair liquid includes following components by mass percentage: glycerol 2%, Propylene glycol 3%, Folium Menthae extract 0.4%, hamamelis extract 6%, Alumen 8%, remaining is silver ion antimicrobial agent and water；Its In, the consumption of silver ion antimicrobial agent is so that in repair liquid, the mass content of silver ion is the consumption of 2ppm.
As further improving, described glycerol is edible glycerol, and propylene glycol is food grade propylene glycol；In antipruritic repair liquid Silver ion antimicrobial agent content by mass percentage is 4-20%；Described water is deionized water or pure water.
As further improving, the preparation method of described silver ion antimicrobial agent comprises the following steps:
1) obtaining purified silver by electrolysis, in purified silver, the mass fraction of silver is more than 99.999999%； During electrolysis, carbon-point is sun level, and silver rod is negative electrode；
2) by purified silver and nitric acid reaction, silver nitrate solution is obtained；
3) utilize sieve technology, filter silver nitrate solution.
Present invention also offers the preparation method of antipruritic repair liquid described above, the preparation method of described antipruritic repair liquid For: medicinal and edible plant extract, propylene glycol, glycerol and silver ion antimicrobial agent are sequentially added in water and are uniformly mixed, use Filter-cloth filtering discharging, is usually with 200 mesh filter-cloth filterings.Certainly, also may be used after adding medicinal and edible plant extract To add hamamelis extract and Alumen.The amount added, is the amount in each formula.
Can be used for treating in gynaecopathia by described antipruritic repair liquid, vagina will be used for by antipruritic repair liquid In.
Can also be used for treating oral disease by antipruritic repair liquid described above, oral cavity will be used for by restoration care liquid In.
Restoration care liquid described above is also used as treating the application of dermatosis external used medicine.
The present invention also has the advantages that
1) present invention uses silver ion antimicrobial agent, after human body uses this restoration care liquid, does not has the nanometer of nanometer silver to carry Body remains in internal, and then fool proof；Also the residual component not having antibacterial to bring after using is got rid of, and then does not has any ring Border load, thus without the healthy problem affecting environment and people that may bring；Do not have aldehydes, acids, chlorinated product etc. anti- The critical defect that microbial inoculum zest is big.The invention of this formula technique overcome that traditional and existing formula technique brings completely to mucosa The zest of skin and the undesirable defect of product efficacy aspect.
2) the antipruritic repair liquid of the present invention uses silver ion antimicrobial agent substitute antibacterial of the prior art, there is consumption more Few, the technique effect that antimicrobial efficiency is higher and stable；Antipruritic repair liquid was placed after 2 years, in gel the content of silver ion compared to Content when being just initially added into only reduces 1-2%.Antipruritic repair liquid, when preserving more than 2 years, has when just starting the most completely Bactericidal effect, do not precipitate generation, do not have use other antibacterial occur when placing for a long time variable color, precipitation and other Material produces reaction or the phenomenon of id reaction.
3) medicinal and edible plant extract of the present invention, have employed 6 kinds of countries and defends ' the medicinal and edible plant mesh that planning commission issues Record ' (the concentrated spray powder) of the inside, thus thoroughly there is no safety, irritating problem.Moreover, the present invention is the most thoroughly Solving the medicinal and edible plant extract (concentrated spray powder) dissolubility in water limited, material stands easily after preparing Produce muddiness and even precipitate and then affect the problem used, this formula technique by add the glycerol of proper proportion and appropriate amount with Propylene glycol, and compound with other material, the problem successfully solving high concentration plant extract turbidity and precipitation so that plant extract Thing consumption is big, and in the case of repair function is enhanced so that antipruritic repair liquid clear, stability is greatly improved, should More preferable by effect.
4) experiment finds, silver ion antimicrobial agent not only has efficient, a safe bactericidal action, and have reparation wound, Make the effect of skin-tightening, and medicinal and edible plant extract (concentrated spray powder) is safe and non-stimulating, and Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Herba Centellae extract, Folium Menthae extract, Aloe extract all have restoration care effect, when silver ion resists During two kinds of composition mixing synergism of microbial inoculum and high concentration plant extract, the effect of its restoration care is compared to being used alone one Plant composition to be greatly reinforced.Moreover, most high concentration plant extracts also have effects such as sterilization, these plant extracts with During silver ion antimicrobial agent mixing synergism, sterilization restoration care effect is higher.Repair can be repair wound, antiinflammatory, Repair lax skin, antipruritic remove abnormal flavour etc.；Nursing can be moisturizing, nutrition, anti-ageing wait for a long time.
5) the antipruritic repair liquid of the present invention is integration of edible and medicinal herbs Chinese herbal medicine extract, safe, non-stimulated, directly act on Affected part, it is possible to more quickly make various disease fully recover.
Detailed description of the invention
Embodiment 1
A kind of antipruritic repair liquid of silver ion antibacterial, the following components including by mass percentage: glycerol 10%, third Glycol 10%, Flos Lonicerae extract 6%, Flos Chrysanthemi Indici extract 6%, Herba portulacae extract 6%, Herba Centellae extract 6%, Herba Menthae Extract 6%, Aloe extract 6%, silver ion antimicrobial agent 20%, remaining is deionized water.This is the present embodiment 1 formula.
Meanwhile, three below comparative formula has been done, it may be assumed that
Comparative formula 1: this comparative formula includes following components by mass percentage: glycerol 10%, propylene glycol 10%, Flos Lonicerae extract 6%, Flos Chrysanthemi Indici extract 6%, Herba portulacae extract 6%, Herba Centellae extract 6%, Folium Menthae extract 6%, Aloe extract 6%, remaining is deionized water.
Comparative formula 2: this comparative formula includes following components by mass percentage: glycerol 10%, propylene glycol 10%, Silver ion antimicrobial agent 20%, remaining is deionized water.
Comparative formula 3: this comparative formula includes following components by mass percentage: glycerol 10%, propylene glycol 10%, Flos Lonicerae extract 6%, Flos Chrysanthemi Indici extract 6%, Herba portulacae extract 6%, Herba Centellae extract 6%, Folium Menthae extract 6%, Aloe extract 6%, nano-silver water solution 20%, remaining is deionized water.Wherein, the quality of silver in nano-silver water solution Mark is 25ppm, and i.e. in formula 3, the concentration of nanometer silver is 5ppm.
Embodiment 1, comparative formula 1, comparative formula 2, comparative formula 3 are respectively used to 30 and suffer from slight moderate cervical erosion Patient.Specifically used method is: sprays every day in vagina 2-3 time, uses 1 gram every time, cures the situation such as table 1 of cervical erosion.
Table 1. different formulations cures the time used by more than 90% patients of cervical ruin
Visible, the formula of the embodiment of the present invention 1, the gynaecopathias such as cervical erosion can be cured fast and efficiently, every day sprays The antipruritic repair liquid 2-3 of embodiment 1 is inferior to intravaginal, just can cure more than 90% slight moderate patients of cervical ruin after 4 days.Say Bright silver ion antimicrobial agent and plant extract have synergism to the reparation of vagina cervical erosion, create unexpected treatment Effect.Meanwhile, using the nanometer silver solution of same concentration to compound with other components, its healing time (13 days) is much higher than use The formula (4 days) of silver ion antimicrobial agent.
Owing to this antipruritic repair liquid uses integration of edible and medicinal herbs and silver ion antimicrobial agent and food grade glycerol, propylene glycol to become completely Point, can be administered orally completely, very safe and efficient！There is compared with prior art products impayable superiority！
The formula of the present embodiment is ' disappear rotten repair liquid '.
Embodiment 2
A kind of antipruritic repair liquid of silver ion antibacterial, the following components including by mass percentage: glycerol 2%, Propylene glycol 3%, Folium Menthae extract 0.4%, hamamelis extract 6%, Alumen 8%, silver ion antimicrobial agent 8%, remaining for go from Sub-water.This is the formula of the present embodiment 2.
Meanwhile, three below comparative formula has been done, it may be assumed that
Comparative formula 4: this comparative formula includes following components by mass percentage: glycerol 2%, propylene glycol 3% is thin Lotus extract 0.4%, hamamelis extract 6%, Alumen 8%, remaining is deionized water.
Comparative formula 5: this comparative formula includes following components by mass percentage: glycerol 2%, propylene glycol 3% is thin Lotus extract 0.4%, Alumen 8%, silver ion antimicrobial agent 8%, remaining is deionized water.
Comparative formula 6: this comparative formula includes following components by mass percentage: glycerol 2%, propylene glycol 3% is thin Lotus extract 0.4%, hamamelis extract 6%, Alumen 8%, nano-silver water solution 8%, remaining is deionized water；Wherein, receive In rice silver aqueous solution, the concentration of nanometer silver is 25ppm, and i.e. in formula 3, the concentration of nanometer silver is 2ppm.
Embodiment 2, comparative formula 4, comparative formula 5, comparative formula 6 are respectively used to 30 and suffer from the many pleats of slack vagina Patient.Specifically used method is: every day uses 2-3 time, uses 1 gram every time, and koro of compacting effect is shown in Table 2.
The situation of table 2 different formulations contracting vagina
Visible, the formula of the embodiment of the present invention 2, vaginal contraction can be made；Use the formula repair liquid 2-3 of embodiment 2 every day Secondary, after using 4 days, the user of more than 90% feels vaginal contraction, detects with colposcope, finds that rugae of vagina reduction is few, viscous The situation that film compacts is consistent with the sensation of human body.This kind of effect is likely to be silver ion disinfectant, Alumen and plant extract altogether Same-action acts synergistically on vagina in vagina, silver ion and aluminium ion (coming from Alumen) so that vagina skin more tightens, Coordinate the repair (promoting the generation of collagen protein inside vagina) of plant extract, three's synergism, thus reach fast The effective koro effect of speed.And nano-silver water solution can not produce such effect.
The present embodiment is ' koro conditioning liquid '.
Embodiment 3
A kind of antipruritic repair liquid of silver ion antibacterial, the following components including by mass percentage: glycerol 10%, Propylene glycol 10%, Folium Menthae extract 2%, hamamelis extract 3%, silver ion antimicrobial agent 4%, remaining is deionized water.
The present embodiment 3 formula, the sterilization of silver ion and the anti-ageing composition of moisturizing, coordinate the sterilization of plant extract and reparation to protect Reason effect, it is possible to make intravaginal environment be in good state, be not likely to produce gynaecopathia such that it is able to make vagina It is chronically at health status.The formula of the present embodiment is used for the vagina of 30 35-60 year women, every day 2-3 time, each 1 gram, After adhering to using 15 days, groups of people substantially feel that intravaginal more lubricates, and detect this part population with colposcope, find this part Crowd's vaginal mucosa keeps compacting smooth state；After using 20 days, all people the most substantially feel that intravaginal more lubricates, with the moon Road microscopy is surveyed, and (old and feeble skin becomes more smooth state through restoration care to find all to keep everyone vaginal mucosa compacting Compact), thus there is the maintenance effect of slow down aging.
The formula of the present embodiment 3 is ' anti-ageing Precerving liquid '.
Embodiment 4
A kind of antipruritic repair liquid of silver ion antibacterial, the following components including by mass percentage: glycerol 5%, Propylene glycol 3% is Flos Lonicerae extract 2%, Flos Chrysanthemi Indici extract 2%, Herba portulacae extract 2%, Herba Centellae extract 2%, thin Lotus extract 2%, Aloe extract 2%, silver ion antimicrobial agent 10%, remaining is deionized water.It is the formula of embodiment 4.
Meanwhile, three below comparative formula has been done, it may be assumed that
Comparative formula 7: this comparative formula includes following components by mass percentage: glycerol 5%, propylene glycol 3%, gold Flos Lonicerae extract 2%, Flos Chrysanthemi Indici extract 2%, Herba portulacae extract 2%, Herba Centellae extract 2%, Folium Menthae extract 2%, Aloe extract 2%, remaining is deionized water.
Comparative formula 8: this comparative formula includes following components by mass percentage: glycerol 5%, propylene glycol 3%, silver Ion antibacterial agent 10%, remaining is deionized water.
Comparative formula 9: this comparative formula includes following components by mass percentage: glycerol 5%, propylene glycol 3%, gold Flos Lonicerae extract 2%, Flos Chrysanthemi Indici extract 2%, Herba portulacae extract 2%, Herba Centellae extract 2%, Folium Menthae extract 2%, Aloe extract 2%, nano-silver water solution 10%, remaining is pure water.Wherein, in nano-silver water solution, the quality of nanometer silver is divided Number is 2ppm for the mass concentration of nanometer silver in 25ppm, i.e. formula 3.
What embodiment 4, comparative formula 7, comparative formula 8, comparative formula 9 were respectively used to 60 18-60 years suffers from pruritus With in the men and women crowd of abnormal flavour.Specifically used method is: sprays every day in affected part 3-6 time, uses 0.5 gram every time, antipruritic goes Abnormal flavour effect is as shown in table 1.
The table 1. different formulations antipruritic time gone used by abnormal flavour
Formula The antipruritic time gone used by abnormal flavour
Embodiment 4 20 seconds
Comparative formula 7 5 minutes
Comparative formula 8 2 minutes
Comparative formula 9 45 seconds
Visible, the formula of the embodiment of the present invention 4, can fast and efficiently anti-inflammation and sterilization, antipruritic, remove abnormal flavour (including oral cavity) Effect (20 seconds).Also finding in application experiment, the formula of the embodiment of the present invention 4 also moves back red detumescence (1-2 days), accelerates to wipe simultaneously Hinder wound healing (healing in 2-3 days), prevent cross infection, alleviation tinea pedis, the effect of tinea unguium.Silver ion antimicrobial agent and medicine food Homologous plant extract synergism in terms of sterilization and reparation makes 20 seconds just can realize the antipruritic effect removing abnormal flavour.
Integration of edible and medicinal herbs and silver ion antimicrobial agent and food grade glycerol, propylene glycol composition is used completely due to this repair liquid, complete Entirely can be administered orally, can be injected in inside oral cavity, be used for antihalitosis (20 seconds) and treat slight oral ulcer, throat inflammation (recovery from illness in 2-3 days).
The antipruritic time gone used by abnormal flavour refers to not itch and abnormal flavour substantially alleviates the time used.
The present embodiment is ' antipruritic repair liquid '/' health care liquid '.
Wherein, in embodiment 1-4, in the silver ion antimicrobial agent used in each embodiment, the concentration of silver ion is In 25ppm, i.e. silver ion antimicrobial agent, the mass fraction of silver ion is 25ppm.Certainly, find in an experiment, silver ion antimicrobial agent The content of middle silver ion can also be other concentration, as long as the concentration of silver ion meets demand, herein in last repair liquid Do not schematically illustrating one by one.
Meanwhile, application finding, any one embodiment of embodiment 1-4 is all used for the skin surface of pruritus or has pruritus Intravaginal all there is antipruritic effect in the 15-60 second, it is also possible to be used in oral cavity reparation diminishing inflammation of wound etc..
The preparation method of the antipruritic repair liquid of embodiment 1-4:
Medicinal and edible plant extract, propylene glycol, glycerol and silver ion antimicrobial agent are sequentially added in water stirring mixing all Even, with 200 mesh filter-cloth filtering dischargings.Certainly also having pick test, seal and preserve, filling and package goes out the step of finished product.When Use hamamelis extract and during Alumen, preparation method be by medicinal and edible plant extract, hamamelis extract, Alumen, third Glycol, glycerol and silver ion antimicrobial agent are sequentially added in water and are uniformly mixed, and with 200 mesh filter-cloth filtering dischargings, i.e. exist It is additionally added hamamelis extract and Alumen after adding medicinal and edible plant extract.
The repair liquid of inventive formulation is mainly used in treating gynaecopathia, in vagina, it is also possible to by restoration care liquid For skin surface, such as at the pudendum of men and women, oxter, ditch stock, breast, oral cavity or other positions of human body, be usually For the surface in skin affected part, as being sprayed at inside oral cavity, above fingernail, on man's glans penis testis.Sky can also be used in On gas, other body surfaces, play refrigerant, sterilization, antipruritic, restrain hidroschesis, abnormal flavour is removed in the gruel that disappears, move back red detumescence, repair minor cut or wound, Antiinflammatory acne removing, alleviate tinea pedis and tinea unguium, beautify the effect of nursing skin.This repair liquid can be with fill at bottle, duckbilled Bottle or pressing spray bottle, aerosol bottle use.Can smear or spray, sparge the affected part of skin.
In a word, inventive formulation than existing formula technique product in gentle safety, high efficiency, pleiotropy, broad spectrum activity, fast Speed aspect has unrivaled advantage！
In the present invention, silver ion antimicrobial agent also has the advantage that
1) silver ion antimicrobial agent high safety
The concentration that A: silver ion antimicrobial agent is general, the most several ppb are to several ppm, and concentration is ultralow；And silver ion is originally Body is also one of trace element in tissue, and trace silver is harmless to human body.
B: vaginal mucosa repeatedly irritant test: negative.Vaginal mucosa is not stimulated.
C: skin allergy repeatedly irritation test: negative.Skin is not stimulated.
D: be suitable for standard for drinking, drink below 1000ml every day, is administered orally and is safe from danger.
Silver ion antimicrobial agent (25ppm) 4-20% is with the addition of (i.e. containing 1.0-in restoration care liquid inside inventive formulation The silver ion of 5.0ppm), toxicity result of the test shows, not stimulates oral mucosa, not stimulates skin.Overcome completely Traditional and existing formula technique zest to skin, the destructive problem to environment and product efficacy aspect are paid no attention to The defect thought！
2) fine silver deionized water solution antibacterial high-efficiency antimicrobial, quick sterilization
Measure silver ion in drinking water according to Department of Health of the United Nations and just can kill the large intestine bar in water completely when being 0.05ppm Bacterium, and do not multiply the flora made new advances in being held up to 90 days；The concentration of silver ions of 0.3ppm can make major part pathogen die, Inactivation of virus；The killing rate of ten minutes spore of 3ppm reaches more than 99%.
With the addition of silver ion antimicrobial agent (25ppm) 4.0-20% inside inventive formulation technology (i.e. restoration care liquid to contain Have the silver ion of 1-5ppm), bactericidal assay result shows, to gold-coloured staphylococci, escherichia coli, Candida albicans in 2 minutes 80-99.99% is reached Deng the bacteriostasis rate of pathogenic bacterium.Sterilization speed is than existing nanometer silver, collargol faster！
3) the antibacterial wide spectrum of silver ion antimicrobial agent
Silver ion antimicrobial agent broad-spectrum antiseptic, shows according to expert's research and testing result, silver ion is to our living environment In common exist antibacterial, virus, for fungus, have good killing effect.
4) silver ion antimicrobial agent stable performance
Silver ion antimicrobial agent can keep the antibacterial effect of more than 2 years；Also can keep the stability of inorganic antiseptic, not allow Easily reacting, product is pure, and colorless and odorless is transparent.Invariant color, does not precipitates.Ion good dispersion, it is easy to quantification, stable, Long shelf-life.
With the addition of inside this formula technique silver ion antimicrobial agent (25ppm) 4-20% (in the most antipruritic repair liquid containing silver from The mass concentration of son is 1-5ppm), stable content result of the test shows, after antipruritic repair liquid normally preserves 2 years, its silver ion Content has almost no change (only reducing 1-2%).Silver ionized water solution is more steady than the collargol of existing formula technique, nanometer silver Fixed.
It should be noted that ppm refers to Solute mass fraction in the present invention, the concentration of certain material is how many ppm, refers to Be the mass fraction shared by this material be how many ppm.Such as: in antipruritic repair liquid, concentration of silver ions is 5ppm, it is antipruritic In repair liquid, silver ion accounts for the mass fraction of this antipruritic repair liquid gross mass is 5ppm, and the meaning can be 1,000,000 grams of antipruritic reparations Silver ion 5 grams in liquid.
As described above, only the preferred embodiments of the invention, when not limiting the scope of present invention enforcement with this, The most generally according to equivalence change simple done by the content described in the claims in the present invention and description of the invention and modification, the most still Within belonging to the claims in the present invention scope.Additionally, summary part and title are intended merely to assist patent document to search it With, not it is used for limiting the interest field of the present invention.

Claims (10)

1. the antipruritic repair liquid of a silver ion antibacterial, it is characterised in that include following components by mass percentage: Glycerol 2-10%, propylene glycol 3-10%, medicinal and edible plant extract 0.4-36%, remaining is silver ion antimicrobial agent and water；Its In, the consumption of silver ion antimicrobial agent is so that in antipruritic repair liquid, concentration of silver ions is the consumption of 1-5ppm；Described integration of edible and medicinal herbs Plant extract include Flos Lonicerae extract, Flos Chrysanthemi Indici extract, Herba portulacae extract, Herba Centellae extract, Folium Menthae extract, One or more in Aloe extract, any one medicinal and edible plant extract accounts for the quality hundred of antipruritic repair liquid gross mass Proportion by subtraction is below 6%.
Antipruritic repair liquid the most as claimed in claim 1, it is characterised in that described antipruritic repair liquid also includes accounting for antipruritic repair liquid The hamamelis extract of gross mass less than 6% and the Alumen accounting for antipruritic repair liquid gross mass less than 8%.
Antipruritic repair liquid the most as claimed in claim 1, it is characterised in that described antipruritic repair liquid includes by mass percentage Following components: glycerol 10%, propylene glycol 10%, Flos Lonicerae extract 6%, Flos Chrysanthemi Indici extract 6%, Herba portulacae extract 6%, Herba Centellae extract 6%, Folium Menthae extract 6%, Aloe extract 6%, remaining is silver ion antimicrobial agent and water；Wherein, The consumption of silver ion antimicrobial agent is so that in antipruritic repair liquid, concentration of silver ions is the consumption of 5ppm.
Antipruritic repair liquid the most as claimed in claim 1, it is characterised in that described antipruritic repair liquid includes by mass percentage Following components: glycerol 2%, propylene glycol 3%, Folium Menthae extract 0.4%, hamamelis extract 6%, Alumen 8%, remaining be silver Ion antibacterial agent and water；Wherein, the consumption of silver ion antimicrobial agent is so that in repair liquid, the concentration of silver ion is the consumption of 2ppm.
Antipruritic repair liquid the most as claimed in claim 1, it is characterised in that described glycerol is edible glycerol, propylene glycol is edible Grade propylene glycol；In antipruritic repair liquid, silver ion antimicrobial agent content by mass percentage is 4-20%；Described water is deionized water Or pure water.
Antipruritic repair liquid the most as claimed in claim 1, it is characterised in that under the preparation method of described silver ion antimicrobial agent includes Row step:
1) obtaining purified silver by electrolysis, in purified silver, the mass fraction of silver is more than 99.999999%；
2) by purified silver and nitric acid reaction, silver nitrate solution is obtained；
3) utilize sieve technology, filter silver nitrate solution.
The preparation method of antipruritic repair liquid the most as claimed in claim 1, it is characterised in that the preparation side of described antipruritic repair liquid Method is: medicinal and edible plant extract, propylene glycol, glycerol and silver ion antimicrobial agent is sequentially added in water and is uniformly mixed, With filter-cloth filtering discharging.
8. the antipruritic repair liquid as described in claim 1-6 any one is as the application in treatment gynaecopathia, and its feature exists In, antipruritic repair liquid is used in vagina.
9. the application in treatment oral disease of the antipruritic repair liquid as described in claim 1-6 any one, it is characterised in that Restoration care liquid is used in oral cavity.
10. the restoration care liquid as described in claim 1-6 any one is as the application for the treatment of dermatosis external used medicine.
CN201610707326.7A 2016-08-23 2016-08-23 Itching relieving repair liquid containing silver ion antibacterial agent, preparation method and application Active CN106109534B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610707326.7A CN106109534B (en) 2016-08-23 2016-08-23 Itching relieving repair liquid containing silver ion antibacterial agent, preparation method and application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610707326.7A CN106109534B (en) 2016-08-23 2016-08-23 Itching relieving repair liquid containing silver ion antibacterial agent, preparation method and application

Publications (2)

Publication Number Publication Date
CN106109534A true CN106109534A (en) 2016-11-16
CN106109534B CN106109534B (en) 2019-12-24

Family

ID=57274791

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610707326.7A Active CN106109534B (en) 2016-08-23 2016-08-23 Itching relieving repair liquid containing silver ion antibacterial agent, preparation method and application

Country Status (1)

Country Link
CN (1) CN106109534B (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107536923A (en) * 2017-09-18 2018-01-05 杨平芝 A kind of oldenlandia diffusa antibacterial gel
CN107551090A (en) * 2017-09-18 2018-01-09 杨平芝 One kind, which is nourished, repairs gel
CN107913394A (en) * 2017-11-22 2018-04-17 苏州祖原堂纳米科技有限公司 A kind of koro gel containing nano-silver ionic
CN108403909A (en) * 2018-05-29 2018-08-17 优乐生活国际有限公司 A kind of external application bacteriostatic agent, preparation method and its application
CN109091513A (en) * 2018-09-25 2018-12-28 黄山永瑞生物科技有限公司 A kind of nano silver hemorrhoid antibacterial agent and preparation method thereof
CN110141640A (en) * 2019-06-17 2019-08-20 福建省海乐威生物工程有限公司 A kind of anti-bacterial, anti-itching Chinese medicine composition and its application
CN112138069A (en) * 2020-11-06 2020-12-29 南京道大药业有限公司 Mild nano-silver antibacterial liquid
CN112245466A (en) * 2020-10-10 2021-01-22 上海耀星国际贸易有限公司 Oral cavity bacteriostatic gel
CN112871042A (en) * 2021-03-01 2021-06-01 上海立霸生物科技有限公司 Production device and manufacturing process of female private disinfection article

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103861035A (en) * 2014-03-11 2014-06-18 广州市洋林生物科技开发有限公司 External composition and external medicine/hygiene product for prevention and treatment of gynecological reproductive tract diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103861035A (en) * 2014-03-11 2014-06-18 广州市洋林生物科技开发有限公司 External composition and external medicine/hygiene product for prevention and treatment of gynecological reproductive tract diseases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
章德林，等: "具有抗感染作用的中药分类研究", 《中草药》 *
韩文佳: "《健康全书》", 31 March 2006, 陕西师范大学出版社 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107536923A (en) * 2017-09-18 2018-01-05 杨平芝 A kind of oldenlandia diffusa antibacterial gel
CN107551090A (en) * 2017-09-18 2018-01-09 杨平芝 One kind, which is nourished, repairs gel
CN107913394A (en) * 2017-11-22 2018-04-17 苏州祖原堂纳米科技有限公司 A kind of koro gel containing nano-silver ionic
CN108403909A (en) * 2018-05-29 2018-08-17 优乐生活国际有限公司 A kind of external application bacteriostatic agent, preparation method and its application
CN109091513A (en) * 2018-09-25 2018-12-28 黄山永瑞生物科技有限公司 A kind of nano silver hemorrhoid antibacterial agent and preparation method thereof
CN110141640A (en) * 2019-06-17 2019-08-20 福建省海乐威生物工程有限公司 A kind of anti-bacterial, anti-itching Chinese medicine composition and its application
CN112245466A (en) * 2020-10-10 2021-01-22 上海耀星国际贸易有限公司 Oral cavity bacteriostatic gel
CN112138069A (en) * 2020-11-06 2020-12-29 南京道大药业有限公司 Mild nano-silver antibacterial liquid
CN112871042A (en) * 2021-03-01 2021-06-01 上海立霸生物科技有限公司 Production device and manufacturing process of female private disinfection article

Also Published As

Publication number Publication date
CN106109534B (en) 2019-12-24

Similar Documents

Publication Publication Date Title
CN106109534A (en) The antipruritic repair liquid of silver ion antibacterial, preparation method and application
CN106334067B (en) Gynecological gel containing silver ion antibacterial agent, preparation method and application
CN111557877B (en) Toothpaste containing centella extract and preparation method thereof
CN106109351B (en) Sterilization repair cleaning agent, preparation method and application thereof
CN109646712A (en) A kind of sulikol liquid dressing and preparation method thereof
CN106491856A (en) Hyaluronic acid bacteriostatic gel
CN103933275A (en) Antibacterial disinfection medicament and preparation method thereof
KR100894439B1 (en) The composition for cosmetics having the prevention effect of atopy
CN106727026B (en) Traditional Chinese medicine acne-removing composition and application thereof
CN107496792A (en) A kind of gel of antiphlogistic antibacterial treatment onychomycosis and preparation method thereof
CN105012581A (en) Fresh aloe antibacterial composite, application and preparing method of fresh aloe antibacterial composite
CN108685987A (en) A kind of Chinese medicine composition and its preparation method and application
CN114306526B (en) Compound broadleaf holly leaf traditional Chinese medicine extract and application thereof in preparing shower gel or hand sanitizer
EP0668768B1 (en) Composition for controlling dermatomycoses and their agents, as well as transpiration and bodily odours
DE19681207B4 (en) Therapeutic use of rubidium ions and preparations
CN101721543A (en) Pure traditional Chinese medicine lotion for treating gynecological diseases
KR20170103390A (en) Unpoisonous anticeptic composition comprising mineral ion activated water
KR20110133982A (en) Antibacterial composition having silver alginate nanocomposite
CN102008586A (en) Effective drug for treating skin disease
CN107469038A (en) A kind of emulsifiable paste for treating tinea pedis and preparation method thereof
CN111544353A (en) Antibacterial oral spray and preparation method thereof
CN104922449A (en) Traditional Chinese medicine disinfection solution and preparation method thereof
CN103341044A (en) Itching-relieving compound preparation and preparation method thereof
CN108392456A (en) A kind of natural skin-care dendrobium candidum surfactant and preparation method thereof
CN109925368A (en) A kind of skin care exfoliating cream of antibacterial tinea pedis-preventing

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: 510000 second and third floor, No.16, Nanye wuheng Road, Longgui Nanling, Baiyun District, Guangzhou, Guangdong Province

Patentee after: Guangzhou Jiekang Pharmaceutical Technology Co., Ltd

Address before: 510000, Baiyun District, Guangdong, Guangzhou province Nanling Long Industrial Zone five, 10 horizontal road, No. two floor

Patentee before: Guangzhou cleaning sanitary articles Co., Ltd.