CN109091513A - A kind of nano silver hemorrhoid antibacterial agent and preparation method thereof - Google Patents
A kind of nano silver hemorrhoid antibacterial agent and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of nano silver hemorrhoid antibacterial agent and preparation method thereof, the bulk pharmaceutical chemicals including following parts by weight: 70~90 parts of nano-class silver colloidal solution, 4~6 parts of witch hazel extract, 1~3 part of Paeoniflorin, 2~4 parts of aucubin, 4~6 parts of matrine, 4~6 parts of cicely seed extract liquor；The sterilization of nano-class silver colloidal solution potent antibacterial, permeability is strong, promotes wound healing, has no drug resistance, can effectively avoid leading to recurrent exerbation obstinate because of drug resistance；Paeoniflorin analgesia, sedation, anti-inflammatory, antiulcer；Aucubin has anti-inflammatory activity；It is matrine antibacterial anti-inflammatory, antiviral；Witch hazel extract has fungal infection the effect of special curative effect, healing of wound；Cicely seed extract liquor can strengthen red blood cell, keep skin more consolidation flexible, and wound is promoted to scab；Each bulk pharmaceutical chemicals are combined external application, and analgesia, antibacterial, sterilization, promotes wound healing at anti-inflammatory, have good therapeutic effect to hemorrhoid.
Description
Technical field
The present invention relates to technical field of Chinese medicine, specifically, being related to a kind of nano silver hemorrhoid antibacterial agent and its preparation side
Method.
Background technique
A kind of common disease positioned at anus area of hemorrhoid, under the mucous membrane of human rectum end and vein burst under anal canal skin
Raw expansion and buckling are formed by soft venous mass.In China, hemorrhoid are the most common anorectal diseases, are known as " ten male nine hemorrhoid ", " ten
The saying of ten hemorrhoid of female ", any age can all fall ill, but with age, disease incidence gradually increases.
The method for the treatment of hemorrhoid mainly passes through operative treatment at present, but operative treatment deposits very big deficiency, and patient can feel difficult
With the pain endured, postoperative turnaround time long easy infection is easy to recur.Drug therapy curative effect on the market is not it is obvious that having
It curative effect but needs to be used for a long time, generates dependence, be difficult radical cure to patient and bring very big puzzlement.
Summary of the invention
It is free from side effects the technical problems to be solved by the present invention are: providing one kind, the fast nano silver hemorrhoid antibacterial of curative effect
Agent and preparation method thereof.
In order to solve the above technical problems, the technical scheme is that
A kind of nano silver hemorrhoid antibacterial agent, the bulk pharmaceutical chemicals including following parts by weight: 70~90 parts of nano-class silver colloidal solution, gold
4~6 parts of thread plum extract liquor, 1~3 part of Paeoniflorin, 2~4 parts of aucubin, 4~6 parts of matrine, cicely seed extract liquor 4
~6 parts.
Preferably, the bulk pharmaceutical chemicals including following parts by weight: 80 parts of nano-class silver colloidal solution, 5 parts of witch hazel extract, Chinese herbaceous peony
2 parts of glycosides, 3 parts of aucubin, 5 parts of matrine, 5 parts of cicely seed extract liquor.
Preferably, the nano-class silver colloidal solution is the electrolysis high-purity nano silver colloidal solution of 25ppm.
Preferably, the witch hazel extract is Kaempferol containing effective component, Quercetin, astragalin and total effective component
The witch hazel extract that mass ratio is 15%.
Preferably, the Paeoniflorin is the extract product of paeoniflorin that the purity extracted in Radix Paeoniae Alba is 98%.
Preferably, the aucubin is the peach jaurel glucoside extract that the purity extracted in Cortex Eucommiae is 98%.
Preferably, the matrine is the kuh-seng alkali extract that the purity extracted in kuh-seng rhizome is 98%.
Preferably, the cicely seed extract liquor is that cicely distills the essential oil liquid produced.
A kind of nano silver hemorrhoid antibacterial agent the preparation method is as follows:
(1) it will be stirred evenly under nano-class silver colloidal solution, witch hazel extract room temperature by formula rate, it is small that static state places 12
When, it must expect that A is spare；
(2) high speed is added in Paeoniflorin, aucubin, matrine, cicely seed extract liquor and material A by formula rate
In emulsification pretreatment machine, the high speed shear 4 hours at a temperature of 75 degree, static state is cooling to be placed 12 hours, at paste-like preparation, it is filling to obtain the final product
Finished product.
After above-mentioned technical proposal, the beneficial effects of the present invention are: a kind of nano silver hemorrhoid antibacterial agent of the invention,
For a kind of important composition, nano-class silver colloidal solution potent antibacterial sterilization in side, permeability is strong, promotes wound healing, without drug resistance
Property can effectively avoid leading to recurrent exerbation obstinate because of drug resistance；Paeoniflorin analgesia, sedation, anti-inflammatory, antiulcer are made
With；Aucubin has apparent anti-inflammatory activity, has significant curative effect for chronic allergy inflammation；Matrine has antibacterial
Anti-inflammatory, antiviral effect；Witch hazel extract has fungal infection the effect of special curative effect, healing of wound；Cicely
Seed extract liquor can strengthen red blood cell, it is possible to improve the colour of skin, keep skin more consolidation flexible, wound is promoted to scab；Each raw material
Medicine is combined external application, and analgesia, antibacterial, sterilization, promotes wound healing at anti-inflammatory, has to the treatment of hemorrhoid quick, is not easy multiple
Hair, feature significant in efficacy.
Specific embodiment
The bulk pharmaceutical chemicals of nano silver hemorrhoid antibacterial agent of the present invention have effects that as follows:
Nano-class silver colloidal solution: nano-Ag particles are directly entered thallus and oxygen metabolism enzyme (- SH) and combine, make thallus suffocate and
Dead unique mechanism of action can kill the microorganisms such as most of bacteriums, fungi, mould, the spore being in contact with it.It is big through the country eight
Authoritative institution's research discovery: it is to pathogenic bacteria of drug-resistant such as antibiotic-resistance E. coli, drug resistance golden staphylococci, drug-resistant pseudomonas aeruginosa, change
Streptococcus pyrogenes, drug resistance enterococcus, anaerobic bacteria etc. have comprehensive antibacterial activity；The bacterium common to burn and scald and wound surface such as gold
Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans and other G+, G- pathogenic bacteria have bactericidal effect；To sand
Chlamydia oculogenitale causes the gonococcus of sexually transmitted disease also to have powerful bactericidal effect.A kind of antibiotic can kill about 6 kinds of diseases
Substance, and nano silver can kill hundreds of pathogenic microorganisms.Kill bacterium, fungi, trichomonad, branch/Chlamydia, gonococcus, sterilization
Effect is strong, has same killing effect to antibiotic drug-fast bacteria.It is found by researches that Ag can kill 650 various bacterias in several minutes.
After nano-Ag particles are in conjunction with cell wall/film of pathogen, can be directly entered thallus, rapidly with the sulfydryl (- SH) of oxygen metabolism enzyme
In conjunction with, inactivate enzyme, block respiratory metabolism so that it is choked to death.Unique sterilization mechanism, so that nano-Ag particles are in low concentration
Pathogenic bacteria can be killed rapidly.Nano-Ag particles permeability with super strength can rapidly permeate into subcutaneous 2mm sterilization, to common thin
Bacterium, stubborn bacteria, drug-resistant bacteria and fungus-caused higher depth tissue infection have good bactericidal effect.Nano silver can
Promote wound healing, promote the reparation and regeneration of damaged cell, remove necrosis and promote granulation, antibacterial anti-inflammatory improves the micro- of periwound tissue and follows
Ring effectively activates and promotes histiocytic growth, accelerate the healing of wound, reduces the generation of scar.Nano-Ag particles benefit
It is produced with patented technology, there is layer protecting film outside, can gradually discharged in human body, so durable antibacterial effect, can kill various
Pathogenic microorganisms, more stronger than antibiotic, the nano-Ag particles unique antimicrobial mechanism of 10nm size can directly kill rapidly bacterium, make
It loses fertility can effectively avoid causing recurrent exerbation long because of drug resistance therefore, it is impossible to produce the next generation of drug resistance
It controls and is not cured.
Witch hazel extract: witch hazel extract has fungal infection special curative effect, and psoriasis, eczema, vein are bent
Or hemorrhoid patients, improvement skin can be impregnated in a manner of hip bath with witch hazel extract, the effect of healing of wound.
Paeoniflorin: have resist myocardial ischemia, anticoagulant inhibition platelet aggregation, spasmolysis, analgesia, sedation,
Anti-inflammatory, anti-ulcer effect, hepatoprotective effect；Adjusting immunity and anti-high-blood-sugar function；Resisting oxygen lack etc..
Aucubin: aucubin is a kind of important bioactive substance, have clearing away damp-heat, diuresis, analgesia,
Decompression, liver protecting, it is antitumor the effects of.It can promote stem cell regenerating, hence it is evident that inhibit the duplication of hepatitis B virus DNA,
Its aglycon and effective polymer are a kind of antibiotic.Aucubin has apparent anti-inflammatory activity, for chronic allergy
Inflammation has significant curative effect, is able to suppress the mouse dropsy of ear of 12-O-tetradecanoylphorbol-13-acetate induction, and inhibiting rate is
72.0~80.0%, Carrageenan induction mouse after podedema and benzoquinones induction writhing movement be significantly improved.Jeong
H.J. the anti-inflammatory effect of research discovery aucubin is related to the specificity inhibition of nuclear factor NF-kB with it.Antigen thorn
Sharp mast cell is capable of the synthesis of the inducing tumor necrosis factor-a (TNF-a) and interleukin-6 (IL-6), and the two has
Proinflammatory effect and immunoloregulation function, expression can be adjusted by NF-kB, and aucubin is able to suppress antigenic stimulus
The p65 subunit of NF-kB is from the displacement in cell cytosol into core in basophilla white blood cell -2H3 mast cell, and passes through prevention
The phosphorylation and degradation of IkBa increases IkBa concentration, and then inhibits NF-kB activity, and lowers TNF-α and IL-6
Synthesis and expression, effect are in dose dependent, and effective dose 50 is respectively 0.101mgmL-1 and 0.19mgmL-1, most
Big inhibiting rate is respectively 73 ± 4.3% and 88.8 ± 5%, and this inhibition may be a kind of special mechanism of action, because of activation
The combination activity of factor protein -1 is not affected.NF-kB is initially because it can promote to encode mouse bone-marrow-derived lymphocyte immunoglobulin
K light chain genetic transcription and gain the name, be highly important nuclear factor, be adjustable the table of inflammation and immunogene
It reaches, closely related with many diseases especially chronic inflammation disease etc., the drug that exploitation can inhibit NFkB becomes anti-inflammatory at present
One new trend of drug research.
Matrine: matrine has the function of antibacterial anti-inflammatory, and 0.3%~1% kuh-seng aqueous slkali is to beta streptococcus, dysentery
Bacillus, proteus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa all have a strong inhibitory effect, and 7.5%~10%
Oxymatrine also have inhibiting effect to dysentery, Escherichia coli, Staphylococcus aureus, beta streptococcus.Banlangen pair
The pathogen such as tubercle bacillus, comma bacillus, Mycobacterium leprae, skin pathogenicity fungi and Leptospira also have certain inhibition to kill
The effect of going out.In addition, containing the active material of anti-Cox B5 virus in Radix Sophorae Tonkinensis Boiled agent, there is certain antivirus action.
Cicely seed extract liquor: cicely seed extract liquor can strengthen red blood cell, it is possible to improve the colour of skin, make skin more
Consolidation is flexible.Skin after use youthens vibrant, can also desalinate age spot, be the liberator of early ageing skin.It is pre- wrinkle resistant
The generation of line -- perhaps this is because carrot seed seed oil can facilitate reepithelialization, similarly, this function can also promote to hurt
Mouth scabs.Other skin problems, such as the wound and ulcer, hickie, itching, fool, eczema, chronic eczema of stream soup can also be improved.
The wound of inflammation and skin and the corn of thick and stiff drying can be treated.
Embodiment one
A kind of nano silver hemorrhoid antibacterial agent of the present embodiment, the bulk pharmaceutical chemicals including following parts by weight: nano-class silver colloidal solution
80g, witch hazel extract 5g, Paeoniflorin 2g, aucubin 3g, matrine 5g, cicely seed extract liquor 5g.
Nano-class silver colloidal solution is the electrolysis high-purity nano silver colloidal solution of 25ppm.
Witch hazel extract is that Kaempferol containing effective component, Quercetin, astragalin and total effective component mass ratio are
15% witch hazel extract.
Paeoniflorin is the extract product of paeoniflorin that the purity extracted in Radix Paeoniae Alba is 98%.
Aucubin is the peach jaurel glucoside extract that the purity extracted in Cortex Eucommiae is 98%.
Matrine is the kuh-seng alkali extract that the purity extracted in kuh-seng rhizome is 98%.
Cicely seed extract liquor is that cicely distills the essential oil liquid produced.
Above-mentioned nano silver hemorrhoid antibacterial agent the preparation method is as follows:
(1) it will be stirred under nano-class silver colloidal solution, witch hazel extract room temperature by the above-mentioned formula rate of the present embodiment equal
Even, static state is placed 12 hours, must expect that A is spare；
(2) by the above-mentioned formula rate of the present embodiment by Paeoniflorin, aucubin, matrine, cicely seed extract liquor
It is added in high-speed shearing emulsion machine with material A, the high speed shear 4 hours at a temperature of 75 degree, static state is cooling to place 12 hours, at paste
Preparation, it is filling to get product.
Embodiment two
A kind of nano silver hemorrhoid antibacterial agent of the present embodiment, the bulk pharmaceutical chemicals including following parts by weight: nano-class silver colloidal solution
78g, witch hazel extract 6g, Paeoniflorin 3g, aucubin 2g, matrine 5g, cicely seed extract liquor 6g.
Nano-class silver colloidal solution is the electrolysis high-purity nano silver colloidal solution of 25ppm.
Witch hazel extract is that Kaempferol containing effective component, Quercetin, astragalin and total effective component mass ratio are
15% witch hazel extract.
Paeoniflorin is the extract product of paeoniflorin that the purity extracted in Radix Paeoniae Alba is 98%.
Aucubin is the peach jaurel glucoside extract that the purity extracted in Cortex Eucommiae is 98%.
Matrine is the kuh-seng alkali extract that the purity extracted in kuh-seng rhizome is 98%.
Cicely seed extract liquor is that cicely distills the essential oil liquid produced.
Above-mentioned nano silver hemorrhoid antibacterial agent the preparation method is as follows:
(1) it will be stirred under nano-class silver colloidal solution, witch hazel extract room temperature by the above-mentioned formula rate of the present embodiment equal
Even, static state is placed 12 hours, must expect that A is spare；
(2) by the above-mentioned formula rate of the present embodiment by Paeoniflorin, aucubin, matrine, cicely seed extract liquor
It is added in high-speed shearing emulsion machine with material A, the high speed shear 4 hours at a temperature of 75 degree, static state is cooling to place 12 hours, at paste
Preparation, it is filling to get product.
Clinical data
1, basic document: inventor collects patient 60 altogether, is divided into two groups；1~test group of test group 2, every group 30.
Test group 1: this group 30, the age 36~55 years old, male 12 people, 18 people of female.
Test group 2: this group 30, the age 41~58 years old, male 15 people, 15 people of female.
2, treatment method and the course for the treatment of
Test group 1: a kind of nano silver hemorrhoid antibacterial agent (embodiment 1) of the invention is applied to affected part, and daily 2~3 times, seven
Days as a treatment course.
Test group 2: a kind of nano silver hemorrhoid antibacterial agent (embodiment 2) of the invention is applied to affected part, and daily 2~3 times, seven
Days as a treatment course.
3, criterion of therapeutical effect
Cure: symptom all disappears；Physico-chemical tests index is normal.
Effective: symptomatology is eliminated or cardinal symptom is eliminated；Physico-chemical tests index is normal.
Effective: cardinal symptom disappears substantially；Physico-chemical tests index makes moderate progress.
Invalid: symptom is unchanged；Physico-chemical tests index is unchanged.
4, it curative effect: is applied with using after medicament of the invention, cures 56, account for 93.3%, effective 3, account for 5%；Effective 1
Example, accounts for 1.7%；Invalid 0, account for 0%；Total effective rate 100%.
The above is the citing of best mode for carrying out the invention, wherein the part that do not address in detail is that this field is common
The common knowledge of technical staff.Protection scope of the present invention is based on the contents of the claims, any based on technology of the invention
The equivalent transformation of enlightenment and progress, also within protection scope of the present invention.
Claims (9)
1. a kind of nano silver hemorrhoid antibacterial agent, which is characterized in that the bulk pharmaceutical chemicals including following parts by weight: nano-class silver colloidal solution 70
~90 parts, 4~6 parts of witch hazel extract, 1~3 part of Paeoniflorin, 2~4 parts of aucubin, 4~6 parts of matrine, cicely
4~6 parts of seed extract liquor.
2. a kind of nano silver hemorrhoid antibacterial agent as described in claim 1, which is characterized in that the raw material including following parts by weight
Medicine: 80 parts of nano-class silver colloidal solution, 5 parts of witch hazel extract, 2 parts of Paeoniflorin, 3 parts of aucubin, 5 parts of matrine, wild Hu
5 parts of Radish seed extract liquor.
3. a kind of nano silver hemorrhoid antibacterial agent as claimed in claim 1 or 2, it is characterised in that: the nano-class silver colloidal solution
For the electrolysis high-purity nano silver colloidal solution of 25ppm.
4. a kind of nano silver hemorrhoid antibacterial agent as claimed in claim 3, it is characterised in that: the witch hazel extract be containing
Imitate the witch hazel extract that ingredient Kaempferol, Quercetin, astragalin and total effective component mass ratio are 15%.
5. a kind of nano silver hemorrhoid antibacterial agent as claimed in claim 4, it is characterised in that: the Paeoniflorin is to extract in Radix Paeoniae Alba
Purity be 98% extract product of paeoniflorin.
6. a kind of nano silver hemorrhoid antibacterial agent as claimed in claim 5, it is characterised in that: the aucubin is in Cortex Eucommiae
The peach jaurel glucoside extract that the purity of extraction is 98%.
7. a kind of nano silver hemorrhoid antibacterial agent as claimed in claim 6, it is characterised in that: the matrine is in kuh-seng rhizome
The kuh-seng alkali extract that the purity of extraction is 98%.
8. a kind of nano silver hemorrhoid antibacterial agent as claimed in claim 7, it is characterised in that: the cicely seed extract liquor is
Cicely distills the essential oil liquid produced.
9. the preparation method of the described in any item nano silver hemorrhoid antibacterial agents of claim 1 to 8, it is characterised in that including walking as follows
It is rapid:
(1) it being stirred evenly under nano-class silver colloidal solution, witch hazel extract room temperature by formula rate, static state is placed 12 hours,
It must expect that A is spare；
(2) high speed shear is added in Paeoniflorin, aucubin, matrine, cicely seed extract liquor and material A by formula rate
In mulser, the high speed shear 4 hours at a temperature of 75 degree, static state is cooling to be placed 12 hours, at paste-like preparation, it is filling up at
Product.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114081998A (en) * | 2021-11-24 | 2022-02-25 | 常州市第二人民医院 | Skin stent and preparation method thereof |
| US20220111095A1 (en) * | 2020-10-14 | 2022-04-14 | Donald Griffith | Antimicrobial combinations system and method |
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