CN104688810A - Antibacterial composition based on natural plant raw material and application of antibacterial composition - Google Patents
Antibacterial composition based on natural plant raw material and application of antibacterial composition Download PDFInfo
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Abstract
The invention relates to an antibacterial composition based on a natural plant raw material and an application of the antibacterial composition, especially prevention and treatment of skin and mucosal diseases and infection of people and animals. The medicine tolerance problem of an antibiotic is an increasingly serious problem in global attention. The invention aims at providing a safe and effective natural antibacterial composition to avoid the problem of the medicine tolerance of the antibiotic instead of the antibiotic. The natural antibacterial composition provided by the invention has a broad-spectrum efficient sterilization effect, and is effective for gram-positive bacterium, gram-negative bacterium and fungus; candida albicans, staphylococcus aureus and escherichia coli can be completely killed within one minute; and meanwhile, the antibacterial composition has good safety. In addition, the composition also has the efficacy of resisting viruses, inflammation and allergy. The composition can be used for preventing and treating skin and mucosal diseases and infection of people and animals. The problem of the medicine tolerance generated by functional antibiotics is avoided.
Description
Technical field
The present invention relates to a kind of bactericidal composition based on natural plant raw material and application thereof, particularly in the control skin of humans and animals, membrane disease and infection.
Background technology
Antibiotic drug resistance problems is a global concern, increasingly serious problem.One of way of head it off finds safely and effectively, not easily maybe can not produce the substitute of drug resistance.The development and application of natural drug is the direction of an effort.At present, the overall state of natural drug is that antibacterial effect is undesirable or do not pass a test.
Summary of the invention
The object of this invention is to provide a kind of safely and effectively based on the bactericidal composition of natural plant raw material to make up above-mentioned deficiency.For realizing this object, the present invention by the following technical solutions:
Based on Chinese traditional medicine technology and international modern biotechnology medical science, screen from a large amount of natural plants safe, efficient, compatible, cost performance is high, not easily produce drug resistance and the natural plant raw material of resource abundance, preparation safety, wide spectrum, efficiently natural antibacterial composition.Said natural antibacterial composition is the bactericidal composition based on natural plant raw material.Infection due to antibacterial usually can cause inflammation and some damage, and therefore, except the antibacterial functions of excellence, bactericidal composition of the present invention also has the function of antiinflammatory and reparation.
Effect of bactericidal composition of the present invention realizes with composition below: a kind of bactericidal composition based on natural plant raw material, is characterized in that by weight percentage, and said composition is grouped into by one-tenth below:
(1) at least one is selected from following composition: Herba Origani oil 0.05%-1.50%, carvacrol (also known as " carvacrol ") 0.05-1.00%;
(2) two are selected from following composition: glycyrrhizic acid dipotassium 0.10-2.00%, Herba portulacae extract 0.50-10.00%;
(3) one carrier components 2.00-10.00% and water safely and effectively.
Said composition can be added further and is one or morely selected from following composition: Spina Gleditsiae extract (Fructus Gleditsia Spina jujubae extract) 0.10-10.0%, Fructus Persicae girder phenol (totarol) 0.10%-10.00%, paeonol 0.10-9.00%, nicotiamide 0.5-6.00%, glycyrrhizin 0.10-3.00%.
Said composition can be added further and is one or morely selected from following composition: Rhizoma Polygoni Cuspidati extract 0.10-4.00%, emodin 0.05-2.00%, Fructus Forsythiae extract (Fructus Forsythiae berry extract) 0.10-10.00%, Fructus Forsythiae ester glycoside 0.05-2.50%, forsythin 0.05-2.50%, Flos Lonicerae extract (Flos Lonicerae extract) 0.10-6.00%, chlorogenic acid 0.05-3.00%, Herba Centellae extract 0.50-3.00%, Asiaticoside 0.10-2.50%, madecassoside 0.10-2.50%, asiatic acid 0.10-2.50%, Madecassic acid 0.10-2.50%, Aloe extract (aloe vera extract) 0.05-5.00%, isoliquiritigenin 0.10-3.00%, liquiritin 0.10-3.00%, isoliquiritin 0.10-3.00%, hamamelis extract 1.00-9.00%, tannic acid (tannic acid) 0.10-2.50%, sodium citrate 0.01-1.00%.
Said composition can be added further and is one or morely selected from following composition: Oleum thymi vulgaris (also known as " thyme oil ") 0.05%-1.50%, thymol (also known as " thymol ") 0.05%-1.00%, Oleum Caryophylli (Flos Caryophylli oil) 0.05%-1.50%, eugenol 0.05%-1.00%.
Described carrier components is safely and effectively the carrier components that satisfied concrete product and dosage form thereof require.Described water is purified water or deionized water.Described product comprises medicine, personal care product, disinfectant and article of everyday use.Be the article of everyday use of emulsion for dosage form, described carrier components can be selected from one of xanthan gum 0.10-1.90% and following ingredients: NatraMulse 0.10-9.90%, the mixture 0.10-9.90% of glyceryl stearate, cetearyl alcohol and stearoyl dilactic acid sodium, or the mixture 0.10-9.90% of effect and " mixture of glyceryl stearate, cetearyl alcohol and stearoyl dilactic acid sodium " equivalence.
This bactericidal composition is used for skin and the membrane disease of prevention and therapy humans and animals.Described disease comprises the similar disease of carbuncle sore, dermatitis, eczema, psoriasis, rosacea, beriberi, tinea unguium, decubital ulcer, burn, scald, sunburn, wound, mosquito bite, red swelling of the skin, stomatitis, vaginitis and animal skin and mucosa.
This bactericidal composition is for preventing and treating skin and the mucosal infections of humans and animals.Described infection comprises the infection of wound, the infection of operation wound, the infection of reproductive tract, the infection of external genitalia, the infection in oral cavity, the infection of brothers and the skin in other contact infection source and the infection of mucosa.
The dosage form of this bactericidal composition is selected from according to concrete product, purposes and usage: cream, emulsion, gel, facial film, liniment, lotion, spray, soap agent, ointment, suppository, tincture, capsule, powder, granule, tablet and the napkin with any combination thing of the present invention.
This bactericidal composition is for the preparation of the product of the skin and membrane disease of preventing, control humans and animals, and described product comprises carbuncle sore for preventing, controlling people, dermatitis, eczema, psoriasis, rosacea, beriberi, tinea unguium, decubital ulcer, burn, scald, sunburn, wound, mosquito bite, red swelling of the skin, stomatitis and colpitic medicine, personal care product and article of everyday use; For the preparation of the medicine of the control skin of animal and the similar disease of mucosa, animal care products and article of everyday use.
This bactericidal composition is for the preparation of the product of the skin and mucosal infections of preventing, control humans and animals, described product comprises medicine and (comprises the medicine of control trauma infection contamination, the medicine of control Surgical wound infections, the medicine of control reproductive tract infection, the medicine that control external genitalia infects, the medicine of control oral cavity infection, and prevent and treat the skin in other contact infection source and the medicine of mucosal infections); Disinfectant (comprises the disinfectant for indoor environment and outdoor environment, for the production of the disinfectant of equipment and apparatus, for the disinfectant of the vehicles such as aircraft, train, automobile, ship, for the disinfectant of armarium, apparatus and articles for use, for contact and/or the equipment of indirect food contact, apparatus, cooker, tableware disinfectant, for the disinfectant of humans and animals skin and mucosa; Disinfectant for animal house and environment); Personal care product (comprise gynecological nursing product, andrology's care product, infant care product, oral care product, brothers' care product, scalp and hair-care care product, the care product at other position of health, and for the care product of the similar applications of animal); And article of everyday use (comprising bath product, the product of clean brothers, clean contact human body skin and/or the product (clothes, quilt, sheet, life appliance etc.) of article of mucosa and the daily product for the similar applications of animal).
antibiotic effect:the antibiotic effect of this compositions can select one or more realizations that become to assign to below: Herba Origani oil, carvacrol (carvacrol), Fructus Persicae girder phenol (totarol), Oleum thymi vulgaris (thyme oil), thymol (thymol), Oleum Caryophylli (Flos Caryophylli oil), eugenol.
Herba Origani oil, carvacrol
Adeps Bovis seu Bubali: labiate; Source is the herb of labiate Adeps Bovis seu Bubali.Herba Origani oil is extracted by Adeps Bovis seu Bubali; Carvacrol is Adeps Bovis seu Bubali main body of oil." China's book on Chinese herbal medicine " is discussed: Adeps Bovis seu Bubali has treatment " measles; Skin pruritus; Skin infection swells and ache; Traumatic injury " function.Modern pharmacological research proves: Herba Origani oil and carvacrol all have excellent anti-microbial property and good safety, are a kind of safe plant antibiotics.In addition, Herba Origani oil and carvacrol also have antiinflammatory; Antioxidation; The effects such as treatment vaginitis, psoriasis, allergy and eczema.
Oleum thymi vulgaris, thymol
Herba thymi vulgaris: another name Herba thymi vulgaris; Labiate; Source is the thymy herb of labiate.Oleum thymi vulgaris is extracted by Herba thymi vulgaris; Thymol is its main component.Herba thymi vulgaris has and integrates feature that is edible, medicinal, that keep healthy.In west, Herba thymi vulgaris is used as " champignon " and be called as " mediation person ".About the antibacterial effect of Oleum thymi vulgaris and thymol, existing deep research.Their bactericidal ranges are wide, effective.Oleum thymi vulgaris and thymol still have antiinflammatory and antioxidative effect; There are some researches prove the oxidation resistance of Oleum thymi vulgaris higher than vitamin E.
Oleum Caryophylli and eugenol
Flos Caryophylli: myrtle; Source is the dry flower of plant clove of myrtaceae.Oleum Caryophylli is extracted by Flos Caryophylli; Eugenol is its main component.There is the anti-microbial property research much about Oleum Caryophylli and eugenol.Summarize it, the anti-microbial property of Oleum Caryophylli and eugenol is fine, and they effectively can also suppress herpes simplex virus (HSV I and HSV II).Remarkable to common pathogenic dermatophytes inhibitory action.In addition, eugenol also has the pharmacologically actives such as antioxidation, antiinflammatory, antitumor, anophelifuge.
Fructus Persicae girder phenol (totarol)
Fructus Persicae girder phenol: be a kind of natural plant extracts by extracting in totara tree.Fructus Persicae girder phenol also can from some other plant (as Herba Rosmarini Officinalis, Cupressaceae etc.) and extract.But the heartwood of New Zealand's totara tree is considered to originate the abundantest.Fructus Persicae girder phenol to gram positive bacteria and gram negative bacteria all effective.There is research report: Fructus Persicae girder phenol has very strong bacteriostatic activity to multiple gram positive bacteria.Fructus Persicae girder phenol also has good anti-oxidation function, is suitable for the application of the product such as skin nursing, mouth care.
anti-inflammatory efficacy:the anti-inflammatory efficacy of bactericidal composition of the present invention can select one or more realizations that become to assign to below: Rhizoma Polygoni Cuspidati extract, Herba portulacae extract, Spina Gleditsiae extract (Fructus Gleditsia Spina jujubae extract), Fructus Forsythiae extract (Fructus Forsythiae berry extract), Fructus Forsythiae ester glycoside, forsythin, Flos Lonicerae extract (Flos Lonicerae extract), chlorogenic acid, glycyrrhizic acid dipotassium, glycyrrhizin, isoliquiritigenin, liquiritin, isoliquiritin, paeonol.
Rhizoma Polygoni Cuspidati extract, emodin
Rhizoma Polygoni Cuspidati: polygonaceae plant; Extract dry rhizome and root that source is polygonaceae plant Rhizoma Polygoni Cuspidati Polygonum CU3pidatum Sieb. etZucc..Emodin is the main component of Rhizoma Polygoni Cuspidati.According to " Chinese Pharmacopoeia " 2010 editions, the function of Rhizoma Polygoni Cuspidati with cure mainly as " carbuncle sore tumefacting virus, burn due to hot liquid or fire, instep play damage for heat-clearing and toxic substances removing, eliminating stasis to stop pain " etc.Modern pharmacological research proves: Rhizoma Polygoni Cuspidati has antibacterial, antivirus action, all has inhibitory action to herpes simplex virus, bacillus pyocyaneus, staphylococcus aureus, hepatitis diplococcus, escherichia coli etc.Be used for the treatment of burn, acute icteric infectious hepatitis, monilial vaginitis etc. clinically.
Glycyrrhizic acid dipotassium, glycyrrhizin, isoliquiritigenin, liquiritin, isoliquiritin
Radix Glycyrrhizae: leguminous plant; Chinese medicine simply.Source is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..According to " Chinese Pharmacopoeia " version in 2010, the function such as " heat-clearing and toxic substances removing ", " coordinating the actions of various ingredients in a prescription " that Radix Glycyrrhizae has; For " carbuncle sore tumefacting virus, cushion toxicity, strong " etc.Be described as in history " state is old " and " king of many medicines ".Radix Glycyrrhizae contains various active composition.Glycyrrhizic acid dipotassium, glycyrrhizin, isoliquiritigenin, liquiritin and isoliquiritin are 5 compounds in Radix Glycyrrhizae.Modern pharmacological research proves: this 5 compounds all has effect of antiinflammatory; In addition, glycyrrhizic acid dipotassium still has antiallergic, antiulcer effect; Glycyrrhizin, isoliquiritigenin, liquiritin and isoliquiritin also have anti-HIV activity.
Herba portulacae extract
Herba portulacae: portulacaceous plant; Source is the dry aerial parts of portulacaceous plant Herba Portulacae.Herba portulacae has another name called " longevity greens/mustard green ", is the Chinese medicine of integration of edible and medicinal herbs simply.According to " Chinese Pharmacopoeia " version in 2010, functions such as " heat-clearing and toxic substances removing, cooling blood for hemostasis " that Herba portulacae has; Cure mainly " carbuncle furuncle, eczema, erysipelas, snake bite and insect sting " etc." national Chinese herbal medicine compilation " is recorded: Herba Portulacae " furuncle swelling toxin, eczema, herpes zoster are controlled in external ".Modern pharmacological research proves: Herba portulacae extract has the multiple efficacies such as antiinflammatory, antiallergic, irritation.Suppress red and swollen successful.
Spina Gleditsiae extract
Spina Gleditsiae: another name sky fourth, soap fourth; Leguminous plant; Source is the dry Spina jujubae of leguminous plant Fructus Gleditsia.According to " Chinese Pharmacopoeia " version in 2010, effect that Spina Gleditsiae has " detumescence poison holding, evacuation of pus, parasite killing "; For " carbuncle from the beginning of or difficulty in discharging of pus, external treatment scabies leprosy " etc." book on Chinese herbal medicine converges and says " is discussed: " Fructus Gleditsia acupuncture is drawn out pus by applying a plaster to the affected part and dispeled the wind.The non-one-tenth person of all carbuncle, can draw to dissipate, will the person of breaking, can draw to lift one's head, routed person can draw with row pus.Be first want agent in infections poison ".Modern pharmacological research proves: Spina Gleditsiae extract has antiinflammatory, antibacterial, the effect such as antitumor and immunity moderation, and antiinflammatory action is obvious.
Fructus Forsythiae extract
Fructus Forsythiae: green grass or young crops sticks up, falls to sticking up another name; Oleaceae plants; Source is the dry fruit of Oleaceae plants Fructus Forsythiae.According to " Chinese Pharmacopoeia " version in 2010, the function that Fructus Forsythiae has " heat-clearing and toxic substances removing, dispersing swelling and dissipating binds "; Cure mainly " carbuncle " etc.Be longer than removing toxicity for eliminating carbuncles and eliminating stagnation, and be described as persons particularly liable to develop skin infection's key medicine.Modern pharmacological research proves: Fructus Forsythiae has antiinflammatory, antibacterial and antioxidation isoreactivity.Better to the antibacterial effect of staphylococcus aureus and staphylococcus epidermidis.
Flos Lonicerae extract, chlorogenic acid
Flos Lonicerae: another name Flos Lonicerae; Caprifoliaceae plant; The flower that source is just opened for caprifoliaceae plant Radix Ophiopogonis, Flos Lonicerae, Flos Lonicerae or the dry flower of hair style Radix Ophiopogonis or band.Chlorogenic acid is the main component of Flos Lonicerae.According to " Chinese Pharmacopoeia " version in 2010, Flos Lonicerae " heat-clearing and toxic substances removing, dispelling wind and heat pathogens.For carbuncle furuncle " etc." book on Chinese herbal medicine just " is discussed: " Flos Lonicerae, is good at removing toxic substances, therefore controls carbuncle, toxic swelling, skin ulcer tinea, Fructus Myricae rubrae, all poison of rheumatism, is really key medicine.The non-Cheng Zheneng of poison falls apart, and poison Cheng Zheneng is burst ".To the sore and toxic of red and swollen heat pain, Flos Lonicerae is common medicine.Modern pharmacological research shows: Flos Lonicerae has obvious antiinflammatory action; It also has the effect of resisting pathogenic microbes, can suppress various bacteria, more obvious to the fungistatic effect of staphylococcus aureus.Chlorogenic acid has antiinflammatory, antibacterial, antioxidation, antiviral, the various active such as immunomodulating and antitumor.
paeonol
Paeonol: another name peonol, paeonol; Source is the dry root bark of ranunculaceae peony.According to " Chinese Pharmacopoeia " version in 2010, it is " blood circulation promoting and blood stasis dispelling " that the function of Cortex Moutan cures mainly, " carbuncle sore tumefacting virus " etc.Paeonol has the effects such as antiinflammatory, analgesia, light speckle, antiallergic.To psoriasis, zona shingles, eczema, skin pruritus, mottle, myalgia, there is good therapeutic efficiency.Jin Yingkai etc. are at their article, " Treatment with TCM psoriasis overview " (Zhejiang Journal of Traditional Chinese Medicine JIUYUE the 46th volume the 9th phase in 2011), middle report: " according to modern scientific research; Cortex Moutan is mainly containing paeonol, paeonoside, the former glycosides of paeonol, peoniflorin etc.; wherein paeonol has the various active effects such as antiinflammatory, immunity moderation, antibacterial, antiviral, has obvious curative effects to treatment psoriasis.”
repair effect:reparation effect of bactericidal composition of the present invention can select one or more realizations that become to assign to below: Aloe extract (aloe vera extract), Herba Centellae extract, asiaticoside, asiaticoside, asiatic acid, Madecassic acid, hamamelis extract, tannic acid (tannic acid), nicotiamide.
Aloe extract
Aloe: liliaceous plant; Source is liliaceous plant Aloe vulgaris, Aloe ferox Miller or other belong to the dry product of concentrated juice of kindred plant leaf together.According to " Chinese Pharmacopoeia " version in 2010, functions such as " purging liver-fires, parasite killing treats infantile malnutrition " that Aloe has; " external treatment tinea skin ulcer " etc.Modern pharmacological research shows: Aloe has the effects such as wound healing, repair tissue damage, antibacterial anti-inflammatory, immunomodulating and moisturizing beauty treatment.Clinical studies show: aloe preparation all has therapeutical effect to wounds such as burn, scald, radiations injury of skin.Research report is had to claim: aloe preparation treatment radiation injury of skin Be very effective.
Herba Centellae extract, asiaticoside, asiaticoside, asiatic acid, Madecassic acid
Herba Centellae: another name Herba Calthae Membranaceae; Samphire; Source is the dry herb of samphire Herba Centellae.According to " Chinese Pharmacopoeia " version in 2010, the function of Herba Centellae cures mainly as " clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling ".For " carbuncle sore tumefacting virus, injury from falling down " etc.According to " China's book on Chinese herbal medicine ", the function of Herba Centellae cures mainly to be also had: " promoting blood circulation and hemostasis "; " edema "; " close pyogenic infections from tumour or sore; Herpes zoster; Treating swelling and pain by traumatic injury; Traumatic hemorrhage; Snake bite and insect sting " etc.Asiaticoside, asiaticoside, asiatic acid, Madecassic acid are the effective ingredient of Herba Centellae.Modern pharmacological research proves: Herba Centellae extract has the effects such as treatment wound healing, cicatrix, burn, wound, leprosy, tuberculosis of skin, scleroderma and antioxidation.
Hamamelis extract, tannic acid (tannic acid)
Radix Hamamelidis Mollis: fragrant in another name wood; Hamamelidaceae Plants; Source is the root of Hamamelidaceae Plants Radix Hamamelidis Mollis, leaf, flower, really.The effects such as the main component of Radix Hamamelidis Mollis is tannic acid (tannic acid), has and repairs impaired skin, accelerating wound healing, and convergence is calm.Be used for the treatment of acne, eczema, decubital ulcer, diaper rash; Repair wound (scar) trace, striae gravidarum, sunburn and moisturizing skin etc.
Nicotiamide
Chinese synonym: vitamin B3, one of vitamin B group.Research proves: nicotiamide has antiinflammatory, wound healing, desalination pigmentation, erythema, macula lutea, moisturizing, and improves the effects such as skin elasticity.
In addition, due to the reason such as factor and product requirement of raw material, likely adjust ph is needed.Sodium citrate is used for achieving this end.
beneficial effect
1. safety is good: the present invention places safety above the other things all the time in prescription, whole process such as one-tenth component selections and preparation technology etc.Compositions of the present invention composition used is all confirm it is safe through a large amount of scientific researches and/or clinical practice.With antibiotic preparation prepared by bactericidal composition of the present invention, there is good safety.
2. broad-spectrum high efficacy: there is wide spectrum, efficiently biocidal efficacies with antibiotic preparation prepared by bactericidal composition of the present invention.All effective to gram positive bacteria, gram negative bacteria and fungus.Antibiotic preparation of the present invention is detected, one minute 100% Killing Candida Albicans, staphylococcus aureus and escherichia coli according to Chinese national standard GB15979-2002 " Disposable Sanitary Accessory sanitary standard ".
3. not easily produce drug resistance: bactericidal composition of the present invention is natural, not containing chemobiotic.Antibacterial not easily produces drug resistance to it.Antibiotic drug resistance problems is a global concern, increasingly serious problem.Product of the present invention has the bactericidal effect of broad-spectrum high efficacy, but antibacterial not easily produces drug resistance to it.This is a significant advantage.
4. natural prodcuts: bactericidal composition of the present invention is a kind of compositions based on natural plant raw material, do not contain the hormone of any chemistry, antibiotic, antiseptic and essence.Coincide people's uphold nature satisfactorily, liking and demand of favor natural prodcuts.
Detailed description of the invention
Below by embodiment, the present invention will be described in more detail.Said embodiment comprises: (A) bactericidal composition of the present invention and preparation technology's embodiment thereof; (B) the effectiveness embodiment of bactericidal composition of the present invention.
(A) bactericidal composition of the present invention and preparation technology's embodiment thereof
embodiment 1.the compositions of the present embodiment is made up of composition (by weight percentage) below:
Composition name percentage by weight
Herba Origani oil 0.05-1.50%
Glycyrrhizic acid dipotassium 0.10-2.00%
Herba portulacae extract 0.50-8.00%
Carrier components 2.00-10.00%
Purified water adds to 100%
Wherein, Herba Origani oil can replace with carvacrol 0.05-1.00%.Carrier components meets a composition of product and dosage form requirement or the mixture of several composition.For article of everyday use " emulsion ", described carrier components can select xanthan gum 0.10-1.90% and NatraMulse 0.10-9.90%.
Preparation technology: the preparation of article of everyday use " emulsion "
1. prepare A phase: get appropriate purified water and be heated to 75 DEG C, add appropriate xanthan gum, be incubated between 70-75 DEG C, stir and make it into transparence emulsion; Then, add appropriate NatraMulse, be incubated between 70-75 DEG C, stirring makes it to be dissolved into emulsion form completely and namely obtains A phase.
2. prepare B phase:
(1) take appropriate glycyrrhizic acid dipotassium and put into a clean container; Add appropriate purified water, and stirring and evenly mixing.
(2), in the solution obtained in (1) step, add appropriate Herba Origani oil and Herba portulacae extract, mix and obtain B phase.
3. mixed-forming
The A phase be mixed with and B phase, stir, and be distributed in sterilized bottle and get product.
embodiment 2.the compositions of the present embodiment is made up of composition (by weight percentage) below:
Composition name percentage by weight
Herba Origani oil 0.05-1.50%
Glycyrrhizic acid dipotassium 0.10-2.00%
Herba portulacae extract 0.50-8.00%
Spina Gleditsiae extract 0.10-10.00%
Carrier components 2.00-10.00%
Purified water adds to 100%
Wherein, Herba Origani oil can replace with carvacrol 0.05-1.00%.Carrier components meets a composition of product and dosage form requirement or the mixture of several composition.For article of everyday use " emulsion ", described carrier components can select xanthan gum 0.10-1.90% and NatraMulse 0.10-9.90%.
Preparation technology: the preparation of article of everyday use " emulsion "
In the preparation technology of embodiment 1, at 2(1) step adds appropriate Spina Gleditsiae extract.Remaining is identical with embodiment 1.
embodiment 3.the compositions of the present embodiment is made up of composition (by weight percentage) below:
Composition name percentage by weight
Carvacrol 0.05-1.00%
Glycyrrhizic acid dipotassium 0.10-2.00%
Herba portulacae extract 0.50-8.00%
Rhizoma Polygoni Cuspidati extract 0.10-4.00%
Herba Centellae extract 0.50-3.00%
Carrier components 2.00-10.00%
Purified water adds to 100%
Wherein, carvacrol can replace with Herba Origani oil 0.05-1.50%.Carrier components meets a composition of product and dosage form requirement or the mixture of several composition.For article of everyday use " emulsion ", described carrier components can select xanthan gum 0.10-1.90% and NatraMulse 0.10-9.90%.
Preparation technology: the preparation of article of everyday use " emulsion "
In the preparation technology of embodiment 1, at 2(1) step adds appropriate Rhizoma Polygoni Cuspidati extract and Herba Centellae extract.At 2(2) step appropriate carvacrol replacement Herba Origani oil.Remaining is identical with embodiment 1.
embodiment 4.the compositions of the present embodiment is made up of composition (by weight percentage) below:
Composition name percentage by weight
Carvacrol 0.05-1.00%
Glycyrrhizic acid dipotassium 0.10-2.00%
Herba portulacae extract 0.50-8.00%
Spina Gleditsiae extract 0.10-10.0%
Flos Lonicerae extract 0.10-6.00%
Aloe extract 0.05-5.00%
Carrier components 2.00-10.00%
Sodium citrate 0.01-1.00%
Purified water adds to 100%
Wherein, carvacrol can replace with Herba Origani oil 0.05-1.50%.Carrier components meets a composition of product and dosage form requirement or the mixture of several composition.For article of everyday use " emulsion ", described carrier components can select xanthan gum 0.10-1.90% and NatraMulse 0.10-9.90%.
Preparation technology: the preparation of article of everyday use " emulsion "
1. prepare A phase: get appropriate purified water and be heated to 75 DEG C, add appropriate xanthan gum, be incubated between 70-75 DEG C, stir and make it into transparence emulsion; Then, add appropriate NatraMulse, be incubated between 70-75 DEG C, stirring makes it to be dissolved into emulsion form completely and namely obtains A phase.
2. prepare B phase:
(1) take appropriate glycyrrhizic acid dipotassium, Spina Gleditsiae extract, Flos Lonicerae extract, put into a clean container, and stirring and evenly mixing.
(2) take appropriate Aloe extract, put into another clean container, then add appropriate purified water, make it mixing and dissolve.
(3) mixture that (1) step obtains is poured in the solution that (2) step obtains, after stirring, add appropriate carvacrol, mix and obtain B phase.
3. mixed-forming
The A phase be mixed with and B phase, stir; Detect pH value, if need adjust ph, add appropriate sodium citrate and stir; Detect qualified after, be distributed in sterilized bottle and get product.
Embodiment 1 to 4 can be optimized further.Embodiment 5 to 7 lists the compositions after optimization.
embodiment 5:the compositions of the present embodiment is made up of composition (by weight percentage (%)) below respectively:
Note: example 1=embodiment 1; Example 2=embodiment 2.
Preparation technology:
The preparation technology of the present embodiment compositions 1 to 3 and the identical of embodiment 1; The preparation technology of compositions 4 to 6 and the identical of embodiment 2.
embodiment 6: the compositions of the present embodiment is made up of composition (by weight percentage (%)) below respectively:
Note: example 3=embodiment 3; Example 4=embodiment 4.
Preparation technology:
The preparation technology of the present embodiment compositions 7 to 9 and the identical of embodiment 3; The preparation technology of compositions 10 to 12 and the identical of embodiment 4.
Antimicrobial emulsion prepared by the present invention has the antibacterial effect of broad-spectrum high efficacy.Bactericidal effect fast and effectively is all had to gram positive bacteria, gram negative bacteria and fungus.Example is as follows:
Antimicrobial emulsion of the present invention is detected according to Chinese national standard GB15979-2002 " Disposable Sanitary Accessory sanitary standard " appendix C 3 " bactericidal property test methods ".Result is as follows:
1. antimicrobial emulsion of the present invention acts on 1min to " Candida albicans ", and killing rate is 100%.
2. antimicrobial emulsion of the present invention acts on 1min to " staphylococcus aureus ", and killing rate is 100%.
3. antimicrobial emulsion of the present invention acts on 1min to " escherichia coli ", and killing rate is 100%.
(B) the effectiveness embodiment of bactericidal composition of the present invention
Bactericidal composition of the present invention has the biocidal efficacies of broad-spectrum high efficacy, and example is as compositions 2,5 and 11.Embodiment 5 is seen below for compositions 2() effectiveness of bactericidal composition of the present invention is described.
embodiment 7.the bactericidal property test of Candida albicans
1. equipment
1.. bacterial strain: Candida albicans ATCC10231, in 5th ~ 6 generations, is provided by China Committee for Culture Collection of Microorganisms's common micro-organisms center.
2.. nertralizer: containing the PBS solution of 2% tween 80.
3.. test specimen: antimicrobial emulsion of the present invention.
2. method
1.. test is undertaken by GB15979-2002 " Disposable Sanitary Accessory sanitary standard " appendix C 3 " bactericidal property test methods ".
2.. " nertralizer qualification test ", by the stock solution of antimicrobial emulsion sample of the present invention, to Candida albicans bactericidal action 0.5min, carries out nertralizer qualification test, repeats 3 tests under 20 DEG C ± 1 DEG C condition.
3.. " bactericidal property test ", by the stock solution of antimicrobial emulsion sample of the present invention, acts on 1min, 2min, 5min, 10min respectively to Candida albicans, tests and repeats 3 times under 20 DEG C ± 1 DEG C condition.
3. result
1.. nertralizer qualification test
Under 20 DEG C ± 1 DEG C condition, three times repeated trials result shows: 1st, 2 groups of average production bacterium numbers are respectively 0 CFU/mL, 1177CFU/mL, and between the 3rd, 4,5 group three groups, average error rate is the 6.43%, 6th group of asepsis growth, the results are shown in following table:
Antimicrobial emulsion sample nertralizer authentication test results of the present invention
2.. antimicrobial emulsion sample of the present invention is to the bactericidal action of Candida albicans
Under 20 DEG C ± 1 DEG C condition, three times repeated trials result shows: the stock solution of antimicrobial emulsion sample of the present invention is to Candida albicans effect 1min, and average bactericidal rate is 100%, the results are shown in following table:
Antimicrobial emulsion sample of the present invention is to the bactericidal action of Candida albicans
4. conclusion
1.. the stock solution of antimicrobial emulsion sample of the present invention makes nertralizer by the PBS solution containing 2% tween 80, to Candida albicans bactericidal action 0.5min, can effectively in and the residual antibacterial of suspension and phage surface, and nertralizer and neutralized reaction product have no adverse effects to test organisms and culture medium.
2.. the stock solution of antimicrobial emulsion sample of the present invention is to Candida albicans effect 1min, and average bactericidal rate is 100%, and sample has bactericidal action to this bacterium.
embodiment 8.the bactericidal property test of staphylococcus aureus
1. equipment
1.. bacterial strain: staphylococcus aureus ATCC6538, in 5th ~ 6 generations, is provided by China Committee for Culture Collection of Microorganisms's common micro-organisms center.
2.. nertralizer: containing the PBS solution of 2% tween 80.
3.. test specimen: antimicrobial emulsion of the present invention.
2. method
1.. test is undertaken by GB15979-2002 " Disposable Sanitary Accessory sanitary standard " appendix C 3 " bactericidal property test methods ".
2.. " nertralizer qualification test ", by the stock solution of antimicrobial emulsion sample of the present invention, to staphylococcus aureus bactericidal action 0.5min, carries out nertralizer qualification test, repeats 3 tests under 20 DEG C ± 1 DEG C condition.
3.. " bactericidal property test ", by the stock solution of antimicrobial emulsion sample of the present invention, acts on 1min, 2min, 5min, 10min respectively to staphylococcus aureus, tests and repeats 3 times under 20 DEG C ± 1 DEG C condition.
3. result
1.. nertralizer qualification test
Under 20 DEG C ± 1 DEG C condition, three times repeated trials result shows: 1st, 2 groups of average production bacterium numbers are respectively 0 CFU/mL, 1177CFU/mL, and between the 3rd, 4,5 group three groups, average error rate is the 6.43%, 6th group of asepsis growth, the results are shown in following table:
antimicrobial emulsion sample nertralizer authentication test results of the present invention
2.. antimicrobial emulsion sample of the present invention is to the bactericidal action of staphylococcus aureus
Under 20 DEG C ± 1 DEG C condition, three times repeated trials result shows: the stock solution of antimicrobial emulsion sample of the present invention is to staphylococcus aureus effect 1min, and average bactericidal rate is 100%, the results are shown in following table:
Antimicrobial emulsion sample of the present invention is to the bactericidal action of staphylococcus aureus
4. conclusion
1.. the stock solution of antimicrobial emulsion sample of the present invention makes nertralizer by the PBS solution containing 2% tween 80, to staphylococcus aureus bactericidal action 0.5min, can effectively in and the residual antibacterial of suspension and phage surface, and nertralizer and neutralized reaction product have no adverse effects to test organisms and culture medium.
2.. the stock solution of antimicrobial emulsion sample of the present invention is to staphylococcus aureus effect 1min, and average bactericidal rate is 100%, and sample has bactericidal action to this bacterium.
embodiment 9.colibacillary bactericidal property test
1. equipment
1.. bacterial strain: escherichia coli 8099, in the 4th generation, is provided by China Committee for Culture Collection of Microorganisms's common micro-organisms center.
2.. nertralizer: containing the PBS solution of 2% tween 80.
3.. test specimen: antimicrobial emulsion of the present invention.
2. method
1.. test is undertaken by GB15979-2002 " Disposable Sanitary Accessory sanitary standard " appendix C 3 " bactericidal property test methods ".
2.. " bactericidal property test ", under 20 DEG C ± 1 DEG C condition, by the stock solution of antimicrobial emulsion sample of the present invention, acts on 1min, 2min, 5min, 10min to escherichia coli respectively, test repetition 3 times.
3. result
Under 20 DEG C ± 1 DEG C condition, three times repeated trials result shows: the stock solution of antimicrobial emulsion sample of the present invention is to escherichia coli effect 1min, and average bactericidal rate is 100%, the results are shown in following table:
Antimicrobial emulsion sample of the present invention is to colibacillary bactericidal action
4. conclusion
The stock solution of antimicrobial emulsion sample of the present invention is to escherichia coli effect 1min, and average bactericidal rate is 100%, and sample has bactericidal action to this bacterium.
Very clear: those skilled in the art can do various amendment, replacement according to thought of the present invention, technology path and/or technical data and/or add.All that do based on thought of the present invention, technology path and/or technical data, nonessential amendments, replacement and/or interpolation all belong to the protection domain of application claims.
Claims (10)
1. based on a bactericidal composition for natural plant raw material, it is characterized in that by weight percentage, said composition is grouped into by one-tenth below:
(1) at least one is selected from following composition: Herba Origani oil 0.05%-1.50%, carvacrol (also known as " carvacrol ") 0.05-1.00%;
(2) two are selected from following composition: glycyrrhizic acid dipotassium 0.10-2.00%, Herba portulacae extract 0.50-10.00%;
(3) one carrier components 2.00-10.00% and water safely and effectively.
2. the bactericidal composition based on natural plant raw material according to claim 1, is characterized in that said composition can be added further and is one or morely selected from following composition: Spina Gleditsiae extract (Fructus Gleditsia Spina jujubae extract) 0.10-10.0%, Fructus Persicae girder phenol (totarol) 0.10%-10.00%, paeonol 0.10-9.00%, nicotiamide 0.5-6.00%, glycyrrhizin 0.10-3.00%.
3., according to the bactericidal composition of any one described in claim 1 to 2 based on natural plant raw material, it is characterized in that said composition can be added further and be one or morely selected from following composition: Rhizoma Polygoni Cuspidati extract 0.10-4.00%, emodin 0.05-2.00%, Fructus Forsythiae extract (Fructus Forsythiae berry extract) 0.10-10.00%, Fructus Forsythiae ester glycoside 0.05-2.50%, forsythin 0.05-2.50%, Flos Lonicerae extract (Flos Lonicerae extract) 0.10-6.00%, chlorogenic acid 0.05-3.00%, Herba Centellae extract 0.50-3.00%, Asiaticoside 0.10-2.50%, madecassoside 0.10-2.50%, asiatic acid 0.10-2.50%, Madecassic acid 0.10-2.50%, Aloe extract (aloe vera extract) 0.05-5.00%, isoliquiritigenin 0.10-3.00%, liquiritin 0.10-3.00%, isoliquiritin 0.10-3.00%, hamamelis extract 1.00-9.00%, tannic acid (tannic acid) 0.10-2.50%, sodium citrate 0.01-1.00%.
4. any one bactericidal composition based on natural plant raw material according to claims 1 to 3, is characterized in that said composition can be added further and is one or morely selected from following composition: Oleum thymi vulgaris (also known as " thyme oil ") 0.05%-1.50%, thymol (also known as " thymol ") 0.05%-1.00%, Oleum Caryophylli (Flos Caryophylli oil) 0.05%-1.50%, eugenol 0.05%-1.00%.
5. the bactericidal composition based on natural plant raw material according to claim 1, it is characterized in that described carrier components is safely and effectively the carrier components that satisfied concrete product and dosage form thereof require, described water is purified water or deionized water, described product comprises medicine, personal care product, disinfectant and article of everyday use, be the article of everyday use of emulsion for dosage form, described carrier components can be selected from one of xanthan gum 0.10-1.90% and following ingredients: NatraMulse 0.10-9.90%, glyceryl stearate, cetearyl alcohol, with the mixture 0.10-9.90% of stearoyl dilactic acid sodium, or effect and " glyceryl stearate, cetearyl alcohol, with the mixture of stearoyl dilactic acid sodium " equivalence mixture 0.10-9.90%.
6. any one bactericidal composition based on natural plant raw material according to Claims 1-4, it is characterized in that this bactericidal composition is for the skin of prevention and therapy humans and animals and membrane disease, described disease comprises the similar disease of carbuncle sore, dermatitis, eczema, psoriasis, rosacea, beriberi, tinea unguium, decubital ulcer, burn, scald, sunburn, wound, mosquito bite, red swelling of the skin, stomatitis, vaginitis and animal skin and mucosa.
7. any one bactericidal composition based on natural plant raw material according to claim 1 and 4, it is characterized in that this bactericidal composition is for preventing and treating skin and the mucosal infections of humans and animals, described infection comprises the infection of wound, the infection of operation wound, the infection of reproductive tract, the infection of external genitalia, the infection in oral cavity, the infection of brothers and the skin in other contact infection source and the infection of mucosa.
8. any one bactericidal composition based on natural plant raw material according to Claims 1-4, is characterized in that the dosage form of this bactericidal composition is selected from according to concrete product, purposes and usage: cream, emulsion, gel, facial film, liniment, lotion, spray, soap agent, ointment, suppository, tincture, capsule, powder, granule, tablet and the napkin with any combination thing of the present invention.
9. any one bactericidal composition based on natural plant raw material according to claim 1 and 4, it is characterized in that the product of this bactericidal composition for the preparation of the skin and membrane disease of preventing, control humans and animals, described product comprises carbuncle sore for preventing, controlling people, dermatitis, eczema, psoriasis, rosacea, beriberi, tinea unguium, decubital ulcer, burn, scald, sunburn, wound, mosquito bite, red swelling of the skin, stomatitis and colpitic medicine, personal care product and article of everyday use; For the preparation of the medicine of the control skin of animal and the similar disease of mucosa, animal care products and article of everyday use thereof.
10. any one bactericidal composition based on natural plant raw material according to claim 1 and 4, it is characterized in that the product of this bactericidal composition for the preparation of the skin and mucosal infections of preventing, control humans and animals, described product comprises medicine and (comprises the medicine of control trauma infection contamination, the medicine of control Surgical wound infections, the medicine of control reproductive tract infection, the medicine that control external genitalia infects, the medicine of control oral cavity infection, and prevent and treat the skin in other contact infection source and the medicine of mucosal infections); Disinfectant (comprises the disinfectant for indoor environment and outdoor environment, for the production of the disinfectant of equipment and apparatus, for the disinfectant of the vehicles such as aircraft, train, automobile, ship, for the disinfectant of armarium, apparatus and articles for use, for contact and/or the equipment of indirect food contact, apparatus, cooker, tableware disinfectant, for the disinfectant of humans and animals skin and mucosa; Disinfectant for animal house and environment); Personal care product (comprise gynecological nursing product, andrology's care product, infant care product, oral care product, brothers' care product, scalp and hair-care care product, the care product at other position of health, and for the care product of the similar applications of animal); And article of everyday use (comprising the product (clothes, quilt, sheet, life are used) of the article of bath product, the product of clean brothers, clean contact human body skin and/or mucosa and the daily product for the similar applications of animal).
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| RU2797944C1 (en) * | 2022-07-11 | 2023-06-13 | федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный аграрный университет" (ФГБОУ ВО Волгоградский ГАУ) | Intravaginal suppositories for the prevention of postpartum endometritis in female farm animals |
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Application publication date: 20150610 |