CN103861035A - External composition and external medicine/hygiene product for prevention and treatment of gynecological reproductive tract diseases - Google Patents
External composition and external medicine/hygiene product for prevention and treatment of gynecological reproductive tract diseases Download PDFInfo
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- CN103861035A CN103861035A CN201410087615.2A CN201410087615A CN103861035A CN 103861035 A CN103861035 A CN 103861035A CN 201410087615 A CN201410087615 A CN 201410087615A CN 103861035 A CN103861035 A CN 103861035A
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Abstract
The invention discloses an external composition and an external medicine/hygiene product for prevention and treatment of gynecological reproductive tract diseases. The composition mainly comprises the following components in parts by weight: 0.3 to 30 parts of cactus, 0.1 to 10 parts of callicarpa nudiflora, 0.1 to 10 parts of Curcuma zedoaria, 0.1 to 10 parts of centella asiatica, 0.1 to 10 parts of lamiophlomis rotate, 0.05 to 5 parts of mint, and 0.0001 to 0.001 part of silver ions. The main preparation of the external medicine/hygiene product is a gel preparation, a cleaning liquid or an external instant effervescent tablet of the composition. The external composition has the characteristics of effectively inhibiting various pathogens and promoting healing of erosion, has an obvious effect for both prevention and treatment of gynecological reproductive tract infection, and is an excellent substitute of traditional external antibiotics and chemical disinfectants.
Description
Technical field
The present invention relates to medicine and hygiene fields, is a kind of for preventing, treat the topical composition of female genital disorders and the external used medicine of making or hygienic article specifically.
Background technology
Female genital tract infection is modal disease in gynaecopathia.The feature of this class disease is that sickness rate is high, Pathogen category many and easily recurrence, and hazardness is extremely wide, remains at present a large clinical difficult problem.Statistics shows according to the study: the sickness rate of China's child-bearing period female genital tract infection disease exceedes 50%, and some areas exceed 70%, the numerous women's of serious harm health and life.The method of control female genital tract infection has the following aspects deficiency at present: 1, the heavily light prevention for the treatment of, adopt antibiotic directly to suppress, kill pathogen, once tackle with regard to the mode of controlling once with morbidity, do not suppress the invasion and attack of pathogen in morbidity early stage, can not stop morbidity from the cause of disease; 2, a kind of antibiotic can only be effective for the pathogenic bacteria of a few species, and the pathogen that can cause reproductive tract infection have tens kinds hundreds of at the most; 3, verified conventional Western medicine preparation still lacks clear and definite inhibition to multiple viral infection at present; 4, have certain side effect, antibiotic use can cause that the drug resistance of pathogen strengthens, and can destroy the ecological environment of slant acidity in reproductive tract, and then destroy the diseases prevention ability of reproductive tract with the flushing liquor of western medicine composition, and the infection of pathogen is more prone to.5, the repair function deficiency of rotten of cervix uteri minced tissue in like product formula technique.
Summary of the invention
Task of the present invention is for above-mentioned technical problem, provide a kind of and can effectively suppress multiple pathogens, promote rotten to the corn healing for preventing and treating the topical composition of gynecological's genital diseases, and external used medicine or hygienic article take said composition as main preparation.
Technological means: the invention discloses a kind ofly for preventing and treating the topical composition of gynecological's genital diseases, said composition is mainly made up of the material of following parts by weight: Radix et Caulis Opuntiae Dillenii 0.3-30 part, Callicarpa nudiflora 0.1-10 part, Rhizoma Curcumae 0.1-10 part, Herba Centellae 0.1-10 part, Radix Lamiophlomidis Rotatae 0.1-10 part, Herba Menthae 0.05-5 part, silver ion 0.0001-0.001 part.
The conventional parts by weight of the main matter of said composition are: Radix et Caulis Opuntiae Dillenii 1-20 part, Callicarpa nudiflora 0.5-8 part, Rhizoma Curcumae 0.5-8 part, Herba Centellae 0.5-8 part, Radix Lamiophlomidis Rotatae 0.5-8 part, Herba Menthae 0.1-3 part, silver ion 0.00025-0.0008 part.
The conventional parts by weight of another kind of the main matter of said composition are: Radix et Caulis Opuntiae Dillenii 3-15 part, Callicarpa nudiflora 1-5 part, Rhizoma Curcumae 1-5 part, Herba Centellae 1-5 part, Radix Lamiophlomidis Rotatae 1-5 part, Herba Menthae 0.1-0.5 part, silver ion 0.0003-0.0008 part.
The preferred weight umber of the main matter of said composition is: 3 parts of Radix et Caulis Opuntiae Dilleniis, 1.5 parts of Callicarpa nudiflora, 1.5 parts of Rhizoma Curcumae, 1.5 parts of Herba Centellaes, 1.5 parts of Radix Lamiophlomidis Rotataes, 0.1 part of Herba Menthae, 0.00035 part of silver ion.
The more preferably parts by weight of the main matter of said composition are: 10 parts of Radix et Caulis Opuntiae Dilleniis, 3 parts of Callicarpa nudiflora, 3 parts of Rhizoma Curcumae, 3 parts of Herba Centellaes, 3 parts of Radix Lamiophlomidis Rotataes, 1 part of Herba Menthae, 0.0005 part of silver ion.
As improvement, in the formula of said composition, also comprise that parts by weight are the chitin of 0.2-20 part; The conventional parts by weight of chitin are 1-10 part, and the parts by weight of preferred chitin are 2 parts.
The invention also discloses a kind of for preventing and treating the external used medicine/hygienic article of gynecological's genital diseases, this external used medicine/hygienic article is instant of gel preparation, cleanout fluid or external effervescent, and its main preparation is above disclosed for preventing and treating the topical composition of gynecological's genital diseases.
Beneficial effect, composite formula of the present invention has following effect:
Radix et Caulis Opuntiae Dillenii, belong to Cactaceae succulent plant, Traditional Chinese Medicine think there is heat-clearing and toxic substances removing, the function of anti-inflammation, in it, mainly contain the compositions such as triterpene, malic acid, succinic acid, modern medicine study confirms that Radix et Caulis Opuntiae Dillenii has obvious bacteriostasis to staphylococcus aureus, candida albicans (fungus), acid-fast bacilli and multiple Gram-positive and negative bacterium.
Callicarpa nudiflora, belongs to Verbenaceae, and Chinese medicine thinks that this plant has the effect of heat clearing and damp drying, wind dispelling insecticide.Main component contains luteolin etc., confirms that through medical research various bacteria is had to the effect that suppresses its activity.
Rhizoma Curcumae, belongs to zingiberaceous plant book on Chinese herbal medicine, and the Rhizoma Curcumae volatile oil including has the effect of invigorating blood circulation, can promote the reparation of mucosal erosion tissue.
Herba Centellae, belongs to samphire, mainly contains Herba Centellae total glycosides, its research shows to have promotion Wound Healing.
Radix Lamiophlomidis Rotatae, Shu Chun type section plant, the Radix Lamiophlomidis Rotatae Saponin that it contains has the effect of promoting blood circulation and stopping pain, removing stasis to stop bleeding, can promote lesion tissue reparation.
Herba Menthae, belongs to gear division plant, mainly, containing volatile matters such as Mentholum (claiming again menthol) and menthone, has the effect of chafe, mucosa teleneuron induction apparatus, and that topical application has is refrigerant, antipruritic, effect of antiinflammatory, pain relieving.
Silver ion (Ag+), bactericidal action is recognized, its principle be mainly Ag+ can with the rapid combination of the sulfydryl-SH of pheron in thalline, make the enzyme loss of activity in thalline, thereby reach bactericidal effect.
Table one is the laboratory sample of above-mentioned preferred substance weight component A for compositions disclosed by the invention (3 parts of Radix et Caulis Opuntiae Dilleniis, 1.5 parts of Callicarpa nudiflora, 1.5 parts of Rhizoma Curcumae, 1.5 parts of Herba Centellaes, 1.5 parts of Radix Lamiophlomidis Rotataes, 0.1 part of Herba Menthae, 0.00035 part of silver ion) the configuration killing effect statistical table to common pathogen.
The killing effect statistical table of the common bacterium of curing the disease of table one
This experiment is the average statistics value to each bacterial strain killing rate under 15 ℃, 20 ℃, 25 ℃ and 30 ℃ of condition of different temperatures, as seen from the table, this compositions to the killing rate of main pathogenic bacterium all more than 90%.
The below beneficial effect at treatment gynecological genital diseases by some experimental example explanation the present invention.
Experimental example 1
Miss Wang, 31 years old, yellow leucorrhea, with abnormal flavour, was chronic bacillary vaginitis, cervicitis the erosion of II degree through examination in hospital, with taking a turn for the better after Chlorhexidine Compound suppository, but multiple relapse.Use the gel preparation of this compositions once a day, after one week, abnormal flavour leucorrhea obviously reduces, and after two weeks, the rotten to the corn face of the rotten to the corn cervical tissue of check is reduced into I degree, and intravaginal rheuminess thing disappears.
Experimental example 2
CHENNU scholar, 43 years old, the more time that has had more than ten years of leucorrhea at ordinary times, hospital diagnosis was chronic vaginitis, cervicitis companion III degree cervical erosion, successively used multi-medicament after leucorrhea take a turn for the better as seen, but III degree cervical erosion has no obvious improvement.One week aftersensation leucorrhea of gel preparation of using this compositions instead obviously reduces, and after two weeks, leucorrhea disappears, and goes hospital's check, and cervical erosion is improved into I degree.
Experimental example 3
Miss Bai, 26 years old, find clear water foam sample leucorrhea, with obvious pruritus, hospital admission is: trichomonal vaginitis, use after metronidazole suppository agent medicine, leucorrhoea grow in quantity, pruritus be without improvement, and checking to hospital is the side effect after this medicine of use.After using the gel preparation of this compositions instead, do not occur untoward reaction, enjoin to suspend and have sexual intercourse during treating, after one week, foam sample leucorrhea obviously reduces, and pruritus also obviously alleviates, leucorrhea disappearance after two weeks, and pruritus alleviation, is almost recovered.
Experimental example 4
Miss Li, 27 years old, feel after marriage to have occurred gynecological's problem half a year, there is bean curd slag specimen leucorrhea, and with obvious symptom of vagina pruritus, be colpitis mycotica (candida albicans infection), cervicitis on inspection, successively used the medicines such as Ketoconazol/Clobetasol Propionate suppository, recurrence in the near future takes a turn for the better.Use the gel preparation of this compositions, once a day, check, leucorrhea obviously reduce after one week, pruritus is improved, check again after two weeks, and bean curd slag specimen leucorrhea disappears, and pruritus is alleviated, and is almost recovered.
Except above-mentioned experimental example, the present invention also obtains extraordinary effect in one group of clinical trial, and clinical trial adopts gel preparation to treat the patient between 22-55 year 67 of different gradient of infection ages, refers to following statistical table.
Table two is tried out demographics table
Table three is treated seven days effect observation statistical tables
| ? | Bacterial vaginitis | Colpitis mycotica | Trichomonal vaginitis | Merge cervical erosion |
| Efficiently individual quantity | 41 | 14 | 9 | 25 |
| Effective percentage % | 100 | 87.5 | 90 | 86.2 |
[0037]table four is treated fortnight effect observation statistical table
Can find out from above-mentioned one group of form, in 67 patients, healing person has 43, improvement have 22, cure rate is 64.1%, total effective rate is 97.00%.
As improvement, in compositions disclosed by the invention, also can add appropriate chitin, chitin has the effect of anti-inflammation under certain molecular weight state, also has the effect of hemostasis, pain relieving, promotion organization healing.
It is main will advocating precautions to gynecological's genital diseases, therefore compositions disclosed by the invention also can be made into cleanout fluid or external effervescent tablet, uses as a kind of hygienic article, and routine cleaning also can effectively prevent the generation of gynecological's genital diseases.
In sum, the present invention has adopted the efficient bacteriostasis of silver ion and the multi-efficiency of Chinese herbal medicine to merge mutually, can effectively prevent, eliminate the healing of gynecological's reproductive tract infection inflammation, promotion wound tissue, the pathogen drug resistance that minimizing use antibiotic brings and the generation of side effect are the high-quality succedaneum of topical antibiotic and chemosterilant.
The specific embodiment
Embodiment 1: the invention discloses a kind ofly for preventing and treating the topical composition of gynecological's genital diseases, said composition is mainly made up of each material of following parts by weight: Radix et Caulis Opuntiae Dillenii 0.3-30 part, Callicarpa nudiflora 0.1-10 part, Rhizoma Curcumae 0.1-10 part, Herba Centellae 0.1-10 part, Radix Lamiophlomidis Rotatae 0.1-10 part, Herba Menthae 0.05-5 part, silver ion 0.0001-0.001 part.
Embodiment 2: the invention discloses a kind ofly for preventing and treating the topical composition of gynecological's genital diseases, conventionally said composition is mainly made up of each material of following parts by weight: Radix et Caulis Opuntiae Dillenii 1-20 part, Callicarpa nudiflora 0.5-8 part, Rhizoma Curcumae 0.5-8 part, Herba Centellae 0.5-8 part, Radix Lamiophlomidis Rotatae 0.5-8 part, Herba Menthae 0.1-3 part, silver ion 0.00025-0.0008 part.
Embodiment 3: the invention discloses a kind ofly for preventing and treating the topical composition of gynecological's genital diseases, conventionally said composition is mainly made up of each material of following parts by weight: Radix et Caulis Opuntiae Dillenii 3-15 part, Callicarpa nudiflora 1-5 part, Rhizoma Curcumae 1-5 part, Herba Centellae 1-5 part, Radix Lamiophlomidis Rotatae 1-5 part, Herba Menthae 0.1-0.5 part, silver ion 0.0003-0.0008 part.
Embodiment 4: the invention discloses a kind ofly for preventing and treating the topical composition of gynecological's genital diseases, the preferred weight umber of the main matter of said composition is: 3 parts of Radix et Caulis Opuntiae Dilleniis, 1.5 parts of Callicarpa nudiflora, 1.5 parts of Rhizoma Curcumae, 1.5 parts of Herba Centellaes, 1.5 parts of Radix Lamiophlomidis Rotataes, 0.1 part of Herba Menthae, 0.00035 part of silver ion.
Embodiment 5: the invention discloses a kind ofly for preventing and treating the topical composition of gynecological's genital diseases, the more preferably parts by weight of the main matter of said composition are: 10 parts of Radix et Caulis Opuntiae Dilleniis, 3 parts of Callicarpa nudiflora, 3 parts of Rhizoma Curcumae, 3 parts of Herba Centellaes, 3 parts of Radix Lamiophlomidis Rotataes, 1 part of Herba Menthae, 0.0005 part of silver ion.
Embodiment 6: as improvement, the invention discloses a kind of for preventing and treating the topical composition of gynecological's genital diseases, the formula of said composition is on the basis of above-mentioned 5 embodiment, also contain the chitin of appropriate parts by weight, the parts by weight of chitin are 0.2-20 part, conventionally consumption is 1-10 part, and preferable amount is 2 parts.
The invention also discloses a kind of for preventing and treating external used medicine/hygienic article of controlling gynecological's genital diseases, this external used medicine/hygienic article is instant of gel preparation, cleanout fluid or external effervescent, and its main preparation is that above-described embodiment is disclosed for preventing and treating the topical composition of gynecological's genital diseases; Generally medicine is made to gel preparation, when use, be applied in affected part best results.
Claims (9)
1. for preventing and treating a topical composition for gynecological's genital diseases, it is characterized in that, said composition is mainly made up of the material of following parts by weight:
2. according to claim 1ly it is characterized in that for preventing and treating the topical composition of gynecological's genital diseases, the parts by weight of the main matter of described compositions are:
3. according to claim 1ly it is characterized in that for preventing and treating the topical composition of gynecological's genital diseases, the parts by weight of the main matter of described compositions are:
4. according to claim 1ly it is characterized in that for preventing and treating the topical composition of gynecological's genital diseases, the parts by weight of the main matter of described compositions are:
5. according to claim 1ly it is characterized in that for preventing and treating the topical composition of gynecological's genital diseases, the parts by weight of the main matter of described compositions are:
According to described in claim 1-5 any one claim for preventing and treating the topical composition of gynecological's genital diseases, it is characterized in that, the formula of described compositions comprises that parts by weight are the chitin of 0.2-20 part.
7. according to claim 6ly it is characterized in that for preventing and treating the topical composition of gynecological's genital diseases, the parts by weight of described chitin are 1-10 part.
8. according to claim 6ly it is characterized in that for preventing and treating the topical composition of gynecological's genital diseases, the parts by weight of described chitin are 2 parts.
9. one kind for preventing and treating external used medicine/hygienic article of controlling gynecological's genital diseases, it is characterized in that: this external used medicine/hygienic article is instant of gel preparation, cleanout fluid or external effervescent, its main preparation be described in claim 1 to 8 any one claim for preventing and treating the topical composition of gynecological's genital diseases.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410087615.2A CN103861035A (en) | 2014-03-11 | 2014-03-11 | External composition and external medicine/hygiene product for prevention and treatment of gynecological reproductive tract diseases |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410087615.2A CN103861035A (en) | 2014-03-11 | 2014-03-11 | External composition and external medicine/hygiene product for prevention and treatment of gynecological reproductive tract diseases |
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| CN103861035A true CN103861035A (en) | 2014-06-18 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106109534A (en) * | 2016-08-23 | 2016-11-16 | 广州洁康卫生用品有限公司 | The antipruritic repair liquid of silver ion antibacterial, preparation method and application |
| CN106334067A (en) * | 2016-08-23 | 2017-01-18 | 广州洁康卫生用品有限公司 | Gynecological gel containing silver-ion bactericide, preparation method and application thereof |
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| CN102018761A (en) * | 2010-11-26 | 2011-04-20 | 田海平 | Drug for treating vagina pruritus and preparation method thereof |
| CN103316033A (en) * | 2013-07-03 | 2013-09-25 | 康晓飞 | Gel and use thereof |
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| CN101919987A (en) * | 2009-06-09 | 2010-12-22 | 夏秀蓝 | Soft capsule for treating vagina |
| CN102018761A (en) * | 2010-11-26 | 2011-04-20 | 田海平 | Drug for treating vagina pruritus and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109534A (en) * | 2016-08-23 | 2016-11-16 | 广州洁康卫生用品有限公司 | The antipruritic repair liquid of silver ion antibacterial, preparation method and application |
| CN106334067A (en) * | 2016-08-23 | 2017-01-18 | 广州洁康卫生用品有限公司 | Gynecological gel containing silver-ion bactericide, preparation method and application thereof |
| CN106109534B (en) * | 2016-08-23 | 2019-12-24 | 广州洁康卫生用品有限公司 | Itching relieving repair liquid containing silver ion antibacterial agent, preparation method and application |
| CN106334067B (en) * | 2016-08-23 | 2019-12-24 | 广州洁康卫生用品有限公司 | Gynecological gel containing silver ion antibacterial agent, preparation method and application |
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