CN108815274A - Clean maintenance bacteriostatic gel of woman and its preparation method and application - Google Patents
Clean maintenance bacteriostatic gel of woman and its preparation method and application Download PDFInfo
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Abstract
The present invention provides clean maintenance bacteriostatic gel of a kind of woman and its preparation method and application, it is related to Amino-Cerv technical field, in the clean maintenance bacteriostatic gel of woman, every 100g gel includes Chinese medical extract 5-15g, alumen 0.01-0.1g, borneol 0.5-2g and chlorhexidine acetate 0.01-0.1g, surplus are water；Wherein, the Chinese medical extract is extracted by frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach, improving currently used for most of antibacterial medicines of gynaecology is made of with acidic disinfectant, long-time service can cause to damage to vagina skin and mucous membrane, the technical issues of even causing hyperblastosis, the clean maintenance bacteriostatic gel of woman provided by the invention is mutually cooperateed with by Chinese medical extract, alumen, borneol and chlorhexidine acetate, it can not only effective bacterio static itching-relieving, and mucous membrane can be repaired, it prevents microorganism from infecting again, promotes female reproductive health.
Description
Technical field
The present invention relates to Amino-Cerv technical fields, more particularly, to clean maintenance bacteriostatic gel of a kind of woman and preparation method thereof
And application.
Background technique
Due to the particularity of female sex organ, gynaecological imflammation has become common, the frequently-occurring disease of adult female, clinical table
Existing varied, the cause of disease is complicated and is often accompanied by a variety of Complicated with Severe diseases, has a significant impact to the life and work of women.
Antibacterial medicines currently used for gynaecology are many kinds of, but most of antibacterial medicines are with acidic disinfectant by one
Determine the product that concentration requires production, such drug, which is used for a long time, to be caused to damage to vagina skin and mucous membrane, or even causes tissue
Hyperplasia.
In view of this, the present invention is specifically proposed.
Summary of the invention
One of the objects of the present invention is to provide a kind of clean maintenance bacteriostatic gels of woman, to improve currently used for the most of gynaecology
Number antibacterial medicines are the products made with acidic disinfectant by a certain concentration requirement, such drug is used for a long time can be to vagina skin
Skin and mucous membrane cause to damage, or even the technical issues of cause hyperblastosis.
The clean maintenance bacteriostatic gel of woman provided by the invention, every 100g gel include Chinese medical extract 5-15g, alumen 0.01-
0.1g, borneol 0.5-2g and chlorhexidine acetate 0.01-0.1g, surplus are water；Wherein, the Chinese medical extract is by frutus cnidii, Huang
Cypress, kuh-seng, radix scutellariae, rheum officinale and azedarach extract.
Further, every 100g gel includes Chinese medical extract 7-12g, alumen 0.02-0.08g, borneol 0.5-1.5g and
Chlorhexidine acetate 0.02-0.08g, surplus are water.
Further, every 100g gel includes Chinese medical extract 8-10g, alumen 0.05-0.07g, borneol 0.8-1.2g and
Chlorhexidine acetate 0.05-0.07g, surplus are water.
Further, the Chinese medical extract is mainly extracted by the raw material of following parts by weight：20-30 parts of frutus cnidii,
10-20 parts of Cortex Phellodendri, 10-20 parts of kuh-seng, 10-20 parts of radix scutellariae, 10-20 parts and azedarach 10-20 parts of rheum officinale；
Preferably, the Chinese medical extract is mainly extracted by the raw material of following parts by weight：It is 22-28 parts of frutus cnidii, yellow
12-18 parts of cypress, 12-18 parts of kuh-seng, 12-18 parts of radix scutellariae, 12-18 parts and azedarach 12-18 parts of rheum officinale.
Further, the clean maintenance bacteriostatic gel of the woman further includes auxiliary material；
Preferably, every 100g gel includes auxiliary material 4-12g；
Preferably, the auxiliary material is selected from least one of thickener, moisturizer and cosolvent.
Further, the thickener is carbomer；
Preferably, the moisturizer is glycerol；
Preferably, the cosolvent is ethyl alcohol.
Further, every 100g gel includes carbomer 0.2-1g, glycerol 3-7g and ethyl alcohol 1-3g；
Preferably, every 100g gel includes carbomer 0.4-0.6g, glycerol 4-6g and ethyl alcohol 1.5-2.5g.
The second object of the present invention is to provide a kind of preparation method of clean maintenance bacteriostatic gel of woman, include the following steps：
By Chinese medical extract, alumen, borneol and acetic acid, oneself fixed and optional auxiliary material is dissolved in water, and is uniformly mixed, is obtained woman
Clean maintenance bacteriostatic gel.
Further, the preparation method of the clean maintenance bacteriostatic gel of the woman, includes the following steps：
(a) Chinese medical extract and alumen are dissolved in the water uniformly mixed, obtain the first mixed liquor；
(b) chlorhexidine acetate and borneol and optional auxiliary material are uniformly mixed, obtain the second mixed liquor；
(c) the first mixed liquor and the second mixed liquor are uniformly mixed, obtain the clean maintenance bacteriostatic gel of woman.
The third object of the present invention is to provide the clean maintenance bacteriostatic gel of woman in the application of prevention and treatment section aspect of inflammation；
Preferably, the gynaecological imflammation includes vaginitis, cervicitis and pelvic inflammatory disease.
The clean maintenance bacteriostatic gel of woman provided by the invention is mutual by Chinese medical extract, alumen, borneol and chlorhexidine acetate
Collaboration, can not only effectively inhibit the growth and breeding of staphylococcus aureus, Candida albicans and Escherichia coli, and can
Mucous membrane is repaired, prevents microorganism from infecting again, while vagina normal flora and acid-base balance can also be maintained, promotes female reproduction strong
Health.
In addition, the clean maintenance bacteriostatic gel of woman provided by the invention does not stimulate mildly, have no toxic side effect, without being diluted,
Directly inject into intravaginal, it is more convenient to use quick.
The preparation method simple process of the clean maintenance bacteriostatic gel of woman provided by the invention, it is easy to operate, work can be suitable for
Industry mass production improves production efficiency.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to an aspect of the present invention, the present invention provides a kind of clean maintenance bacteriostatic gel of woman, every 100g gel includes
Chinese medical extract 5-15g, alumen 0.01-0.1g, borneol 0.5-2g and chlorhexidine acetate 0.01-0.1g, surplus are water；Wherein,
The Chinese medical extract is extracted by frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach.
In the clean maintenance bacteriostatic gel of woman provided by the invention, in every 100g gel, the typical but non-limit of Chinese medical extract
Quality for example 5g, 5.5g of property processed, 6g, 6.5g, 7g, 7.5g, 8g, 8.5g, 9g, 9.5g, 10g, 10.5g, 11g, 11.5g,
12g, 12.5g, 13g, 13.5g, 14g, 14.5g or 15g parts.
Chinese medical extract is mutually cooperateed with by frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach, being capable of effective anti-inflammatory
It is antipruritic, antibacterial bacteriostatic, while can also have promoting blood circulation and stopping pain, it dissipates stasis of blood life newly, promotes female reproductive system health.
In the clean maintenance bacteriostatic gel of woman provided by the invention, in every 100g gel, alumen it is typical but non-limiting
Quality for example 0.01g, 0.015g, 0.02g, 0.025g, 0.03g, 0.035g, 0.04g, 0.045g, 0.05g, 0.055g,
0.06g, 0.065g, 0.07g, 0.075g, 0.08g, 0.085g, 0.09g, 0.095g or 0.1g.
Alumen also known as alum is forged, soluble easily in water or glycerol does not dissolve in alcohol, has dissolving phlegm, eliminating dampness, antidiarrheal, hemostasis, removing toxic substances
And the effect of desinsection.
In the clean maintenance bacteriostatic gel of woman provided by the invention, in every 100g gel, borneol it is typical but non-limiting
Quality for example 0.5g, 0.6g, 0.7g, 0.8g, 0.9g, 1g, 1.1g, 1.2g, 1.3g, 1.4g, 1.5g, 1.6g, 1.7g, 1.8g,
1.9g or 2g.
Borneol is the crystallization obtained from the resin and volatile oil of kapur, enters the heart, lung channel, has and leads to all keys, dissipates stagnated fire,
Screen improving eyesight is gone, the effect of swelling and pain relieving.
In the clean maintenance bacteriostatic gel of woman provided by the invention, in every 100g gel, the typical but non-limit of chlorhexidine acetate
Quality for example 0.01g, 0.015g of property processed, 0.02g, 0.025g, 0.03g, 0.035g, 0.04g, 0.045g, 0.05g,
0.055g, 0.06g, 0.065g, 0.07g, 0.075g, 0.08g, 0.085g, 0.09g, 0.095g or 0.1g.
Chlorhexidine acetate is the efficient spectrum fungicide of biguanides, makes cellular content by changing bacterial cytoplasm membrane permeability
It leaks out and plays bactericidal effect, stronger killing effect is all had to most of Gram-positive bacillus and negative bacillus, to green
Purulence bacillus and fungi also have good killing effect.
The clean maintenance bacteriostatic gel of woman provided by the invention is mutual by Chinese medical extract, alumen, borneol and chlorhexidine acetate
Collaboration, can not only effectively inhibit the growth and breeding of staphylococcus aureus, Candida albicans and Escherichia coli, and can
Mucous membrane is repaired, prevents microorganism from infecting again, while vagina normal flora and acid-base balance can also be maintained, promotes female reproduction strong
Health.
In addition, the clean maintenance bacteriostatic gel of woman provided by the invention does not stimulate mildly, have no toxic side effect, without being diluted,
Directly inject into intravaginal, it is more convenient to use quick.
In the preferred embodiment of the present invention, Chinese medical extract mainly by following parts by weight raw material extract and
At：20-30 parts of frutus cnidii, 10-20 parts of Cortex Phellodendri, 10-20 parts of kuh-seng, 10-20 parts of radix scutellariae, 10-20 parts of rheum officinale and azedarach 10-20
Part.
It in the preferred embodiment of the invention, prepares in the raw material of Chinese medical extract, the typical but non-limit of frutus cnidii
For example 20,21,22,23,24,25,26,27,28,29 or 30 parts of the mass fraction of property processed.
Frutus cnidii is the dry mature fruit of umbelliferae cnidium monnieri, and warm-natured, bitter has eliminating dampness, wind-dispelling, desinsection and temperature
The effect of kidney and enhancing body.
In the preferred embodiment of the invention, prepare in the raw material of Chinese medical extract, Cortex Phellodendri it is typical but unrestricted
For example 10,11,12,13,14,15,16,17,18,19 or 20 parts of mass fraction of property.
Cortex Phellodendri bitter, cold in nature, clearing heat and detoxicating, purging intense heat eliminating dampness can treat skin sore and skin eczema.
In the preferred embodiment of the invention, prepare in the raw material of Chinese medical extract, kuh-seng it is typical but unrestricted
For example 10,11,12,13,14,15,16,17,18,19 or 20 parts of mass fraction of property.
Kuh-seng, draft or undershrub have effects that clearing heat and promoting diuresis, antibacterial anti-inflammatory and stomach invigorating expelling parasite.
In the preferred embodiment of the invention, prepare in the raw material of Chinese medical extract, radix scutellariae it is typical but unrestricted
For example 10,11,12,13,14,15,16,17,18,19 or 20 parts of mass fraction of property.
The root of radix scutellariae is used as medicine, and bitter is cold in nature, there is the effect of heat-clearing and damp-drying drug, purging fire for removing toxin and arresting bleeding and miscarriage prevention.
In the preferred embodiment of the invention, prepare in the raw material of Chinese medical extract, rheum officinale it is typical but unrestricted
For example 10,11,12,13,14,15,16,17,18,19 or 20 parts of mass fraction of property.
Rheum officinale, which has, attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis and removing toxic substances and other effects.
It in the preferred embodiment of the invention, prepares in the raw material of Chinese medical extract, the typical but non-limit of azedarach
For example 10,11,12,13,14,15,16,17,18,19 or 20 parts of the mass fraction of property processed.
Azedarach also known as bitter Siberian cocklebur, have effects that heat-clearing, eliminating dampness and desinsection.
In the preferred embodiment of the present invention, the preparation method of Chinese medical extract includes the following steps：By cnidium monnieri
Son, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach add water to refine, and filter to take filtered fluid, are concentrated, dry, obtain Chinese medical extract.
In the preferred embodiment of the present invention, the clean maintenance bacteriostatic gel of woman further includes auxiliary material.
By the way that auxiliary material is added so that manufactured gynaecology conserves the more uniform of each raw material mixing of gel.
In present invention further optimization embodiment, every 100g gel includes auxiliary material 4-12g.
In the preferred embodiment of the invention, in every 100g gel, the typical but non-limiting quality of auxiliary material is such as
For 4g, 4.5g, 5g, 5.5g, 6g, 6.5g, 7g, 7.5g, 8g, 8.5g, 9g, 9.5g, 10g, 10.5g, 11g, 11.5g or 12g.
In the preferred embodiment of the present invention, auxiliary material be selected from one of thickener, moisturizer and cosolvent or
It is several.
In present invention further optimization embodiment, thickener is carbomer.
Carbomer is acrylic resin, and with stronger hygroscopicity, carbomer is neutralized after making carboxylic ions, due to
The repulsive interaction of negative electrical charge stretches strand disperse, is in great swelling state, and have viscosity.
In the preferred embodiment of the present invention, moisturizer is glycerol.
Glycerol has stronger hygroscopicity, the moisture on skin can be allowed not distribute fastly very much, while suitably from air
Draw aqueous vapor.
In the preferred embodiment of the present invention, cosolvent is ethyl alcohol, more preferably dehydrated alcohol.
Since chlorhexidine acetate and borneol are not readily dissolved in water, use ethyl alcohol for cosolvent, first by chlorhexidine acetate and
Borneol is dissolved in ethyl alcohol, then soluble in water by emulsifying, and forms lotion.
In the preferred embodiment of the present invention, every 100g gel includes carbomer 0.2-1g, glycerol 3-7g and second
Alcohol 1-3g.
In the preferred embodiment of the invention, in every 100g gel, the typical but non-limiting quality of carbomer
For example 0.2g, 0.3g, 0.5g, 0.6g, 0.8g, 1g, 1.1g, 1.2g, 1.3g, 1.4g, 1.5g, 1.6g, 1.8g or 2g；Glycerol
Typical but non-limiting quality for example 3g, 3.2g, 3.5g, 3.8g, 4g, 4.2g, 4.5g, 4.8g, 5g, 5.2g, 5.5g,
5.8g, 6g, 6.2g, 6.5g, 6.8g or 7g；Typical but non-limiting quality for example 1g, 1.2g of ethyl alcohol, 1.5g, 1.6g,
1.7g, 1.8g, 1.9g, 2g, 2.1g, 2.2g, 2.5g, 2.8g or 3g.
According to the second aspect of the invention, the present invention provides a kind of preparation method of gynaecology oxidation bacteriostatic gel, packets
Include following steps：By Chinese medical extract, alumen, borneol and acetic acid, oneself fixed and optional auxiliary material is dissolved in water, and mixing is equal
It is even, obtain the clean maintenance bacteriostatic gel of woman.
The preparation method simple process of the clean maintenance bacteriostatic gel of woman provided by the invention, it is easy to operate, work can be suitable for
Industry mass production improves production efficiency.
In the preferred embodiment of the present invention, the preparation method of the clean maintenance bacteriostatic gel of woman, includes the following steps：
(a) Chinese medical extract and alumen are dissolved in the water uniformly mixed, obtain the first mixed liquor；
(b) chlorhexidine acetate and borneol and optional auxiliary material are uniformly mixed, obtain the second mixed liquor；
(c) the first mixed liquor and the second mixed liquor are uniformly mixed, obtain the clean maintenance bacteriostatic gel of woman.
In present invention further optimization embodiment, woman it is clean maintenance bacteriostatic gel preparation method, specifically include as
Lower step：
(A) Chinese medical extract and alumen are dissolved in the water uniformly mixed, obtain the first mixed liquor；
(B) chlorhexidine acetate and borneol are dissolved in dehydrated alcohol, are uniformly mixed, then glycerol is added, is uniformly mixed,
Obtain the second mixed liquor；
(C) carbomer is dissolved in the water, emulsification uniformly, obtains third mixed liquor：
(D) the first mixed liquor, the second mixed liquor and third mixed liquor are uniformly mixed, obtain the clean maintenance bacteriostatic gel of woman.
According to the third aspect of the present invention, the present invention provides the clean maintenance bacteriostatic gels of woman in terms of preventing and treating gynaecological imflammation
Application.
In the present invention, gynaecological imflammation includes but is not limited to vaginitis, cervicitis and pelvic inflammatory disease.
Technical solution provided by the invention is further described below with reference to embodiment and comparative example.
Embodiment 1
A kind of clean maintenance bacteriostatic gel of woman is present embodiments provided, every 100g gel includes Chinese medical extract 5g, alumen
0.1g, borneol 2g and chlorhexidine acetate 0.01g, surplus are water, and wherein Chinese medical extract is by following original according to the mass fraction
Material is extracted and is prepared：20 parts of frutus cnidii, 20 parts of Cortex Phellodendri, 10 parts of kuh-seng, 20 parts of radix scutellariae, 10 parts and 20 parts of azedarach of rheum officinale.
Embodiment 2
A kind of clean maintenance bacteriostatic gel of woman is present embodiments provided, every 100g gel includes Chinese medical extract 15g, alumen
0.01g, borneol 0.5g and chlorhexidine acetate 0.1g, surplus are water, and wherein Chinese medical extract is as follows by according to the mass fraction
Raw material extraction is prepared：30 parts of frutus cnidii, 10 parts of Cortex Phellodendri, 20 parts of kuh-seng, 10 parts of radix scutellariae, 20 parts and 10 parts of azedarach of rheum officinale.
Embodiment 3
A kind of clean maintenance bacteriostatic gel of woman is present embodiments provided, every 100g gel includes Chinese medical extract 7g, alumen
0.08g, borneol 0.5g and chlorhexidine acetate 0.08g, surplus are water, and wherein Chinese medical extract is as follows by according to the mass fraction
Raw material extraction is prepared：22 parts of frutus cnidii, 18 parts of Cortex Phellodendri, 12 parts of kuh-seng, 18 parts of radix scutellariae, 12 parts and 18 parts of azedarach of rheum officinale.
Embodiment 4
A kind of clean maintenance bacteriostatic gel of woman is present embodiments provided, every 100g gel includes Chinese medical extract 12g, alumen
0.02g, borneol 1.5g and chlorhexidine acetate 0.02g, surplus are water, and wherein Chinese medical extract is as follows by according to the mass fraction
Raw material extraction is prepared：28 parts of frutus cnidii, 12 parts of Cortex Phellodendri, 18 parts of kuh-seng, 12 parts of radix scutellariae, 18 parts and 12 parts of azedarach of rheum officinale.
Embodiment 5
A kind of clean maintenance bacteriostatic gel of woman is present embodiments provided, every 100g gel includes Chinese medical extract 8g, alumen
0.07g, borneol 0.8g and chlorhexidine acetate 0.07g, surplus are water, and wherein Chinese medical extract is as follows by according to the mass fraction
Raw material extraction is prepared：25 parts of frutus cnidii, 15 parts of Cortex Phellodendri, 15 parts of kuh-seng, 15 parts of radix scutellariae, 15 parts and 15 parts of azedarach of rheum officinale.
Embodiment 6
A kind of clean maintenance bacteriostatic gel of woman is present embodiments provided, every 100g gel includes Chinese medical extract 10g, alumen
0.05g, borneol 1.2g and chlorhexidine acetate 0.05g, surplus are water, and wherein Chinese medical extract is as follows by according to the mass fraction
Raw material extraction is prepared：25 parts of frutus cnidii, 15 parts of Cortex Phellodendri, 15 parts of kuh-seng, 15 parts of radix scutellariae, 15 parts and 15 parts of azedarach of rheum officinale.
Embodiment 7
A kind of clean maintenance bacteriostatic gel of woman is present embodiments provided, every 100g gel includes Chinese medical extract 9g, alumen
0.06g, borneol 1g and chlorhexidine acetate 0.06g, surplus are water, and wherein Chinese medical extract is by following original according to the mass fraction
Material is extracted and is prepared：25 parts of frutus cnidii, 15 parts of Cortex Phellodendri, 15 parts of kuh-seng, 15 parts of radix scutellariae, 15 parts and 15 parts of azedarach of rheum officinale.
Embodiment 8
Present embodiments provide a kind of preparation method of clean maintenance bacteriostatic gel of woman, the clean maintenance of woman that embodiment 1-7 is provided
Bacteriostatic gel is prepared in the method：Specifically comprise the following steps：
(1) add water to refine frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach, filter to take filtered fluid, be concentrated, do
It is dry, obtain Chinese medical extract.
(2) Chinese medical extract and alumen are dissolved in the water uniformly mixed, obtain the first mixed liquor；
(B) chlorhexidine acetate and borneol are dissolved in dehydrated alcohol, are uniformly mixed, then glycerol is added, is uniformly mixed,
Obtain the second mixed liquor；
(C) carbomer is dissolved in the water, emulsification uniformly, obtains third mixed liquor：
(D) the first mixed liquor, the second mixed liquor and third mixed liquor are uniformly mixed, obtain the clean maintenance bacteriostatic gel of woman.
Comparative example 1
This comparative example provides a kind of clean maintenance bacteriostatic gel of woman, the difference is that, is not added withered with embodiment 7
Alum.
Comparative example 2
This comparative example provides a kind of clean maintenance bacteriostatic gel of woman, the difference is that, ice is not added with embodiment 7
Piece.
Comparative example 3
This comparative example provides a kind of clean maintenance bacteriostatic gel of woman, the difference is that, vinegar is not added with embodiment 7
Sour Chlorhexidine.
Comparative example 4
This comparative example provides a kind of clean maintenance bacteriostatic gel of woman, with embodiment 7 the difference is that, traditional Chinese medicine extraction
Frutus cnidii is not added in the raw material of object.
Comparative example 5
This comparative example provides a kind of clean maintenance bacteriostatic gel of woman, with embodiment 7 the difference is that, traditional Chinese medicine extraction
Radix scutellariae is not added in the raw material of object.
Comparative example 6
This comparative example provides a kind of clean maintenance bacteriostatic gel of woman, with embodiment 7 the difference is that, traditional Chinese medicine extraction
Rheum officinale is not added in the raw material of object.
Comparative example 7
This comparative example provides a kind of clean maintenance bacteriostatic gel of woman, with embodiment 7 the difference is that, traditional Chinese medicine extraction
Azedarach is not added in the raw material of object.
Comparative example 8
This comparative example provides a kind of clean maintenance bacteriostatic gel of woman, with embodiment 7 the difference is that, traditional Chinese medicine extraction
Object is prepared by the following raw material extraction according to the mass fraction：55 parts of frutus cnidii, 5 parts of Cortex Phellodendri, 5 parts of kuh-seng, 5 parts of radix scutellariae,
25 parts and 5 parts of azedarach of rheum officinale.
The preparation method of the clean maintenance bacteriostatic gel of the woman that comparative example 1-8 is provided is with embodiment 7, and details are not described herein.
Test example 1
The clean maintenance bacteriostatic gel of woman that embodiment 1-7 and comparative example 1-8 are provided is placed in 37 DEG C of insulating boxs 3 months, is protected
Relative humidity 75% is held, bacteriostasis property test is carried out, as a result shown in table 1.
The clean maintenance bacteriostatic gel bacteriostasis property tables of data of 1 woman of table
It is antibacterial solidifying to can be seen that the clean maintenance of woman provided by the invention for the comparison of embodiment 1-7 and blank control group from table 1
Glue passes through the growth that can effectively inhibit Escherichia coli, staphylococcus aureus and Candida albicans, prevents microorganism from infecting again,
Vagina normal flora balance is maintained, female reproductive health is promoted.
From the comparison of embodiment 1-7 and comparative example 1-3 as can be seen that the clean maintenance bacteriostatic gel of woman that embodiment 1-7 is provided
It is mutually cooperateed with by Chinese medical extract, alumen, borneol and chlorhexidine acetate that extra fine quality matches, to Escherichia coli, golden yellow
The inhibitory effect of staphylococcus and Candida albicans is more preferably.
From the comparison of embodiment 1-7 and comparative example 4-8 as can be seen that when the Chinese medical extract in the clean maintenance bacteriostatic gel of woman
When being prepared by the extraction of the frutus cnidii of extra fine quality number, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach, fungistatic effect is more
It is good.
Test example 2
The female patient of gynecological disease is suffered from selected from 800, the age is 29-45 years old, is married, non-menstrual period and bosom
In the pregnancy period, it is randomly divided into 16 groups, every group of 50 people, nonspecific vaginitis (III, IV degree of vagina cleanness degree) 15 in every group is trichomonas
Vaginitis 15, colpomycosis 20, the clean maintenance bacteriostatic gel difference of the woman that embodiment 1-7 and comparative example 1-8 are provided
It is pushed into patient's intravaginal, one day every time, is used continuously 15 days, the 16th group is blank control group, respectively symptom before and after recording medicine,
Sign, laboratory check leukorrhea routine inspection as a result, the results are shown in Table 2.
Control efficiency table of the clean maintenance bacteriostatic gel of 2 woman of table to vaginitis
Note：The standard of healing is clinical symptoms, sign disappearance, and nonspecific vaginitis vaginal fluid checks that cleannes exist
I-II degree, leukorrhea routine inspection pathogen are turned out cloudy；The standard of improvement is clinical symptoms, sign partial disappearance, non-specific vagina
Scorching vaginal fluid checks cleannes part in I-II degree, and leukorrhea routine inspection pathogen is turned out cloudy；Invalid standard be it is clinical,
Sign is without change, and nonspecific vaginitis vaginal fluid checks cleannes in III-IV degree, and leukorrhea routine inspection pathogen is still
For the positive.
The comparison of embodiment 1-7 and blank control group is as can be seen that the clean maintenance suppression of woman that embodiment 1-7 is provided from table 2
The effective percentage of bacterium gel reaches 90% or more, and cure rate also reaches 70% or more, this illustrates the clean maintenance of woman provided by the invention
Bacteriostatic gel can effectively inhibit and remove vaginal pathogenic, and bacterio static itching-relieving prevents microorganism from infecting again, maintain the normal bacterium of vagina
Group's balance, restores normal physiological context.
From table 2, the comparison of embodiment 1-7 and comparative example 1-3 are as can be seen that the clean maintenance of woman that embodiment 1-7 is provided presses down
Chinese medical extract, alumen, borneol and the chlorhexidine acetate that bacterium gel is matched by extra fine quality mutually cooperate with, so that it is to vagina
Scorching control efficiency is more preferably.
From the comparison of embodiment 1-7 and comparative example 4-8 as can be seen that when the Chinese medical extract in the clean maintenance bacteriostatic gel of woman
When being prepared by the extraction of the frutus cnidii of extra fine quality number, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach, so that it is to vagina
Scorching control efficiency is more preferably.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, those skilled in the art should understand that：Its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of clean maintenance bacteriostatic gel of woman, which is characterized in that every 100g gel includes Chinese medical extract 5-15g, alumen 0.01-
0.1g, borneol 0.5-2g and chlorhexidine acetate 0.01-0.1g, surplus are water；Wherein, the Chinese medical extract is by frutus cnidii, Huang
Cypress, kuh-seng, radix scutellariae, rheum officinale and azedarach extract.
2. the clean maintenance bacteriostatic gel of woman according to claim 1, which is characterized in that every 100g gel includes Chinese medical extract
7-12g, alumen 0.02-0.08g, borneol 0.5-1.5g and chlorhexidine acetate 0.02-0.08g, surplus are water.
3. the clean maintenance bacteriostatic gel of woman according to claim 1, which is characterized in that every 100g gel includes Chinese medical extract
8-10g, alumen 0.05-0.07g, borneol 0.8-1.2g and chlorhexidine acetate 0.05-0.07g, surplus are water.
4. the clean maintenance bacteriostatic gel of woman according to claim 1-3, which is characterized in that the traditional Chinese medicine extraction owner
It to be extracted by the raw material of following parts by weight：20-30 parts of frutus cnidii, 10-20 parts of Cortex Phellodendri, 10-20 parts of kuh-seng, radix scutellariae 10-20
Part, 10-20 parts and azedarach 10-20 parts of rheum officinale；
Preferably, the Chinese medical extract is mainly extracted by the raw material of following parts by weight：22-28 parts of frutus cnidii, Cortex Phellodendri 12-
18 parts, 12-18 parts of kuh-seng, 12-18 parts of radix scutellariae, 12-18 parts and azedarach 12-18 parts of rheum officinale.
5. the clean maintenance bacteriostatic gel of woman according to claim 1-3, which is characterized in that further include auxiliary material；
Preferably, every 100g gel includes auxiliary material 4-12g；
Preferably, the auxiliary material is selected from least one of thickener, moisturizer and cosolvent.
6. the clean maintenance bacteriostatic gel of woman according to claim 5, which is characterized in that the thickener is carbomer；
Preferably, the moisturizer is glycerol；
Preferably, the cosolvent is ethyl alcohol.
7. the clean maintenance bacteriostatic gel of woman according to claim 1-3, which is characterized in that every 100g gel includes card
Wave nurse 0.2-1g, glycerol 3-7g and ethyl alcohol 1-3g；
Preferably, every 100g gel includes carbomer 0.4-0.6g, glycerol 4-6g and ethyl alcohol 1.5-2.5g.
8. the preparation method of the clean maintenance bacteriostatic gel of woman according to claim 1-7, which is characterized in that including such as
Lower step：
By Chinese medical extract, alumen, borneol and acetic acid, oneself fixed and optional auxiliary material is dissolved in water, and is uniformly mixed, that is, is made
Obtain the clean maintenance bacteriostatic gel of woman.
9. the preparation method of the clean maintenance bacteriostatic gel of woman according to claim 8, which is characterized in that include the following steps：
(a) Chinese medical extract and alumen are dissolved in the water uniformly mixed, obtain the first mixed liquor；
(b) chlorhexidine acetate and borneol and optional auxiliary material are uniformly mixed, obtain the second mixed liquor；
(c) the first mixed liquor and the second mixed liquor are uniformly mixed, obtain the clean maintenance bacteriostatic gel of woman.
10. application of the clean maintenance bacteriostatic gel of woman according to claim 1-7 in terms of preventing and treating gynaecological imflammation；
Preferably, the gynaecological imflammation includes vaginitis, cervicitis and pelvic inflammatory disease.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110279846A (en) * | 2019-08-08 | 2019-09-27 | 武汉易瑞生物医药有限公司 | Immune activation peptide adjusts antibacterial gynecological gel |
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Application publication date: 20181116 |