CN103432486A - Traditional Chinese medicine composition for treating leukoplakia vulvae - Google Patents
Traditional Chinese medicine composition for treating leukoplakia vulvae Download PDFInfo
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- CN103432486A CN103432486A CN2013102119129A CN201310211912A CN103432486A CN 103432486 A CN103432486 A CN 103432486A CN 2013102119129 A CN2013102119129 A CN 2013102119129A CN 201310211912 A CN201310211912 A CN 201310211912A CN 103432486 A CN103432486 A CN 103432486A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating leukoplakia vulvae. Within effective dosages, the traditional Chinese medicine composition is composed by the following components of cortex phellodendri, radix sophorae flavescentis, fructus cnidii, radix stemonae, divaricate saposhnikovia root, cotex dictamni, dried alum, borneol and realgar. The invention also relates to the application of the traditional Chinese medicine composition in preparing drugs for treating leukoplakia vulvae, for preventing trichomonas vaginalis and for preventing vaginal fungal infections. Preparations of the drugs traditional Chinese medicine composition comprise suppository and lotion. The traditional Chinese medicine composition provided by the invention has an effective rate of 100%, and is high in curative rate and fast in efficiency.
Description
Technical field
The invention belongs to tcm field, particularly the Chinese medicine for the treatment of vagina disease.
Background technology
Leukoplakia vulvae, have another name called leukoplakia vulvae, points out limitation or the diffusivity white speckle of present women's genital skin, can spread to two preaxials, perineum and anus, but seldom invade urethral orifice and vestibule.Disease is seen pudendal pruritus, xerosis cutis, and plumpness bleaches, and follows the string, and even the atrophy ulceration, have pain and burn feeling.Leukoplakia vulvae is again white diseases of vulva, leukoplakia vulvae or vulvar dystrophy.In fact so-called leukoplakia vulvae refers to tissue degeneratiaon and the discolored disease that pudendum local nerve and angiodystrophia cause.Usually the skin of pudendum part and mucosa bleach chap or atrophic disease, be referred to as " leukoplakia vulvae " clinically.The clinical pathology inspection has atypical cell to increase the survivor to belong to Chinese medicine " pudendal pruritus " " pudendum cloudy pain " " pain over the perineum " category, how because of dampness-heat of the liver, to make a bet and to invade the stain pudendum, or blood-deficiency leading to hyperactivity of the liver, and the essence and bloods such as the hepatic and renal YIN deficiency, kidney yang deficiency can not moisten supports due to pudendum.The patient who suffers from leukoplakia vulvae has the Symptoms appearance of pruritus vulvae, sometimes scorching hot, pain can also be arranged.The type of leukoplakia vulvae has a lot, comprises that constitutional atrophy of vulva, atrophic sclerosis lichen, leukoplakia vulvae, white macula vaginitis, pudendum are withered etc. usually the vulvopathy that skin bleaches with mucosa, chap becomes atrophy to be referred to as to leukoplakia vulvae clinically.The traditional Chinese medical science is called cloudy moss, the erosion of vulva, the erosion of the vulva, pain over the perineum to leukoplakia vulvae, and leukoplakia vulvae or a kind of precancerous lesion.
The Chinese invention patent application that application number is 201110461191.8, introduced with Rhizoma Polygoni Cuspidati, Flos Carthami, Radix Arnebiae (Radix Lithospermi), Cortex Phellodendri, Radix Sophorae Flavescentis, Herba speranskiae tuberculatae, Borneolum Syntheticum treatment leukoplakia vulvae, its Main Function is blood circulation promoting and blood stasis dispelling, anti-inflammation, antipruritic, expelling wind and removing dampness, heat-clearing and toxic substances removing, analgesia detumescence, strengthens cutaneous circulation, and the subcutaneous elastic purpose of promotion is arranged.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition is intended to treat the vagina white macula.Two of purpose of the present invention is to provide the preparation of described Chinese medicine composition, and said preparation is easy to use, successful.Three of purpose of the present invention is to provide the preparation method of described preparation, and the method program is simple, is suitable for large-scale production.
For achieving the above object, technical scheme of the present invention is:
Chinese medicine composition is characterized in that: composed of the following components in effective dose: Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, white section, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum, Realgar.Described effective dose, refer to this area routine administration dosage, specifically can be with reference to " the dosage of mentioning in Chinese pharmacopoeia or " Chinese medicine voluminous dictionary ".
Preferably, described Chinese medicine composition, described Chinese medicine composition is composed of the following components by weight:
Cortex Phellodendri 180-220 part,
Radix Sophorae Flavescentis 180-220 part,
Fructus Cnidii 180-220 part,
The white 180-220 of section part,
Radix Saposhnikoviae 80-120 part,
Favus skin 28-33 part,
Dried Alumen 180-220 part,
Borneolum Syntheticum 22-28 part,
Realgar 13-18 part.
Preferably, described Chinese medicine composition, described Chinese medicine composition is composed of the following components by weight:
200 parts of Cortex Phellodendris,
200 parts of Radix Sophorae Flavescentiss,
200 parts of Fructus Cnidiis,
200 parts, white section,
100 parts of Radix Saposhnikoviaes,
30 parts of favus skins,
200 parts of dried Alumens,
25 parts of Borneolum Syntheticums,
15 parts of Realgars,
Preferably, described Chinese medicine composition, is characterized in that, also comprises Mentholum in described Chinese medicine composition, and the weight of described Mentholum is equivalent to the 1/50-1/25 of described dried Alumen weight.Described Mentholum adds when preparing lotion, has both possessed the effect of antipruritic, antiinflammatory and pain relieving, can increase again the comfort level while using.
The application of described Chinese medicine composition in the medicine of preparation treatment leukoplakia vulvae.
The application of described Chinese medicine composition in the medicine of the anti-trichomonas vaginitis of preparation.
The application of described Chinese medicine composition in the medicine of the anti-vagina fungal infection of preparation.
The preparation of described Chinese medicine composition, described preparation is suppository or lotion.
Further, the preparation method of described preparation, the dosage form of described preparation is suppository, and the Cortex Phellodendri of formula ratio, Radix Sophorae Flavescentis, Fructus Cnidii, white section, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum and Realgar are ground to form to powdery, makes suppository.
Further, the preparation method of described preparation, the dosage form of described preparation is lotion, the Cortex Phellodendri of formula ratio, Radix Sophorae Flavescentis, Fructus Cnidii, white section, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum and Realgar are ground to form to powdery, fully mix, obtain the Traditional Chinese drug mixture powder, and make decoction liquor, in described decoction liquor, add Sal to make it to become isotonic liquid, and add the Mentholum of formula ratio; Contain the described Traditional Chinese drug mixture powder of 8-12 gram in every 300 milliliters of described decoction liquor.
Beneficial effect of the present invention is: in the present invention, Cortex Phellodendri has heat clearing and damp drying under effective dose, and pathogenic fire purging is except steaming, the effect of detoxification sore treatment; Radix Sophorae Flavescentis has the effect of anti-inflammation, heat clearing and damp drying under effective dose.Fructus Cnidii can warming the kidney to invigorate YANG, and dampness, dispel the wind, parasite killing; White section, nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Radix Saposhnikoviae is expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic under effective dose.Favus skin has heat clearing and damp drying, the effect of the removing toxic substances of dispeling the wind.Dried Alumen has expectorant,
dampness, antidiarrheal, hemostasis, the effect of removing toxic substances and parasite killing.Borneolum Syntheticum has all keys, loose stagnated fire, removing nebula improving eyesight, the effect of reducing swelling and alleviating pain.Realgar has parasite killing and treats skin ulcer, and anticancer effect relieves internal heat.Mentholum energy chafe mucosa, in antipruritic, antiinflammatory, pain relieving, part has cool feeling.Effective percentage 100% of the present invention, cure rate is high, rapid-action.
The specific embodiment
Illustrated embodiment is in order better content of the present invention to be described, but is not that content of the present invention only limits to illustrated embodiment.So those of ordinary skill in the art carry out nonessential improvement and adjustment according to the foregoing invention content to embodiment, still belong to protection scope of the present invention.
The bacteriostatic experiment of embodiment 1 Chinese medicine composition
One formula and preparation thereof
Described Chinese medicine composition, described Chinese medicine composition is composed of the following components:
Cortex Phellodendri 1800g,
Radix Sophorae Flavescentis 1800g,
Fructus Cnidii 1800g,
The white 1800g of section,
Radix Saposhnikoviae 1200g,
Favus skin 330g,
2200 parts of dried Alumens,
280 parts of Borneolum Syntheticums,
180 parts of Realgars.
Each component of formula ratio is made to powder, fully mix, obtain the Traditional Chinese drug mixture powder.
Two bacteriostatic experiments
1 experiment grouping: Experimental agents is selected and is breathed out the cefradine (the accurate word H23021929 of traditional Chinese medicines, lot number 0309303) that the refining medicine company limited of medicine three is produced, and called after cefradine group, be diluted into the twice mass concentration.Select the group called after Chinese drug-treated group that above-mentioned Traditional Chinese drug mixture powder is trial drug; Described Chinese drug-treated group biggest quality volumetric concentration is 8%, is diluted to 10 volume gradient concentrations, refers to table 2.Selecting the Chongqing Hil'an Pharmaceutical Co., Ltd bacterium must the gram washing liquid be Experimental agents, and the maximum volume diluted concentration is 1%, is diluted to 8 volume gradient concentrations, refers to table 1.
2 experimental techniques: select respectively following three kinds of bacterium as experimental bacteria, 1) staphylococcus epidermidis (Staphylococcus epidermidis), ATCC20015; 2) escherichia coli (Escherichia, e.coli), ATCC20019; 3) white Streptobacillus moniliformis, ATCC10076.
Press solid double dilution method dilution cefradine with nutrient agar (China Inst. of Quarantine Inspection Sciences and Beijing road and bridge technology company limited Joint Production, lot number 041110), make the positive control medicine.With reference to " bacteriostatic experiment in Chinese pharmacopoeia, observation cefradine group, bacterium must gram washing liquid group (each Concentraton gradient) and decoction liquor (each Concentraton gradient) each experimental bacteria growing state on nutrient agar panel obtain the minimum inhibitory concentration (MIC) of medicine; Or.And the blank group is set.Experimental result refers to table 1 and table 2.
Table 1 bacterium must gram washing liquid bacteriostatic experiment result
| Drug level (%) | Staphylococcus epidermidis | Escherichia coli | The white Streptobacillus moniliformis |
| 1.0 | - | -① | -① |
| 0.5 | - | + | + |
| 0.25 | -① | + | + |
| 0.125 | + | + | + |
| 0.0625 | + | + | + |
| 0.03125 | + | + | + |
| o.015625 | + | + | + |
| 0.0078125 | + | + | + |
| The cefradine group | - | - | - |
| Positive bacteria growth control group | + | + | + |
| The blank group | - | - | - |
+ long bacterium;-not long bacterium; 1. minimum inhibitory concentration.
Table 2 Traditional Chinese drug mixture powder bacteriostatic experiment result
+ long bacterium;-not long bacterium; 1. minimum inhibitory concentration; The concentration of Traditional Chinese drug mixture powder is the mass body volume concentrations.
As can be seen from Table 1 and Table 2, cefradine group, positive bacteria growth group, blank group are all set up; Bacterium must the gram washing liquid be 0.25% to the staphylococcic minimum inhibitory concentration of epidermis, and the minimum inhibitory concentration of escherichia coli, white Streptobacillus moniliformis is to 1.0%.Described Traditional Chinese drug mixture powder is 1.0% to the staphylococcic minimum inhibitory concentration of epidermis, and the minimum inhibitory concentration of escherichia coli, white Streptobacillus moniliformis is to 2.0%.
Embodiment 2 is used for the treatment of the medicine of vagina fungal infection
Described Chinese medicine composition, described Chinese medicine composition is by composed of the following components:
Cortex Phellodendri 2200g,
Radix Sophorae Flavescentis 2200g,
Fructus Cnidii 2200g,
The white 2200g of section,
Radix Saposhnikoviae 800g,
Favus skin 280g,
Dried Alumen 1800g,
Borneolum Syntheticum 220g,
Realgar 130g.
By above-mentioned each component grind into powder, abundant mix homogeneously, get the mixed powder of 100 gram as mainly.Accompany and add certain adjuvant and be prepared into suppository.Suppository is filled in intravaginal, within every two days one, changes.60 routine fungal infection patients are implemented to treatment, effective percentage 100%, wherein cure rate 80%.
Embodiment 3 is used for the treatment of the medicine of vagina white macula
Described Chinese medicine composition, described Chinese medicine composition is composed of the following components:
Cortex Phellodendri 2000g,
Radix Sophorae Flavescentis 2000g,
Fructus Cnidii 2000g,
The white 2000g of section,
Radix Saposhnikoviae 1000g,
Favus skin 300g,
Dried Alumen 2000g,
Borneolum Syntheticum 250g,
Realgar 150g,
Mentholum 66g.
Each component of formula ratio is made to powder, fully mix, obtain the Traditional Chinese drug mixture powder, and make decoction liquor, in described decoction liquor, add Sal to make it to become isotonic liquid; Contain the described Traditional Chinese drug mixture powder of 10 gram in every 300 milliliters of described decoction liquor.Described decoction liquor is as vaginal lotion.100 vagina white macula patients adopt this medicine to carry out vagina cleaning.Wherein, a cleaning in three days every 4 hours once.After three days, 100 patients all feel sx↓.After medication three days, change every 6 hours into once, continue 4 days; Within the 8th day every 12 hours, use once.Vagina white macula patient's cure rate is 90%.
Finally explanation is, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although with reference to preferred embodiment, the present invention is had been described in detail, those of ordinary skill in the art is to be understood that, can modify or be equal to replacement technical scheme of the present invention, and not breaking away from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of claim scope of the present invention.
Claims (10)
1. Chinese medicine composition, is characterized in that: composed of the following components in effective dose: Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, white section, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum, Realgar.
2. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is composed of the following components by weight:
3. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is composed of the following components by weight:
4. Chinese medicine composition according to claim 1, is characterized in that, also comprises Mentholum in described Chinese medicine composition, and the weight of described Mentholum is equivalent to the 1/50-1/25 of described dried Alumen weight.
5. the application of the described Chinese medicine composition of claim 1-4 any one in the medicine of preparation treatment leukoplakia vulvae.
6. the application of the described Chinese medicine composition of claim 1-4 any one in the medicine of the anti-trichomonas vaginitis of preparation.
7. the application of the described Chinese medicine composition of claim 1-4 any one in the medicine of the anti-vagina fungal infection of preparation.
8. the preparation of the described Chinese medicine composition of claim 1-4 any one, is characterized in that, described preparation is suppository or lotion.
9. the preparation method of preparation according to claim 8, the dosage form of described preparation is suppository, it is characterized in that: the Cortex Phellodendri of formula ratio, Radix Sophorae Flavescentis, Fructus Cnidii, white section, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum and Realgar are ground to form to powdery, make suppository.
10. the preparation method of preparation according to claim 8, the dosage form of described preparation is lotion, it is characterized in that: the Cortex Phellodendri of formula ratio, Radix Sophorae Flavescentis, Fructus Cnidii, white section, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum and Realgar are ground to form to powdery, fully mix, obtain the Traditional Chinese drug mixture powder, and make decoction liquor, in described decoction liquor, add Sal to make it to become isotonic liquid, and add the Mentholum of formula ratio; Contain the described Traditional Chinese drug mixture powder of 8-12 gram in every 300 milliliters of described decoction liquor.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104490959A (en) * | 2014-12-29 | 2015-04-08 | 江苏春申堂药业有限公司 | Traditional Chinese medicinal preparation for treating intractable leukoplakia vulvae of woman |
| CN104857468A (en) * | 2015-05-13 | 2015-08-26 | 四川金堂海纳生物医药技术研究所 | Leukoplakia vulvae treating medicine for oral administration and preparation method thereof |
| CN108815274A (en) * | 2018-07-25 | 2018-11-16 | 博凯健康产业有限公司 | Clean maintenance bacteriostatic gel of woman and its preparation method and application |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490959A (en) * | 2014-12-29 | 2015-04-08 | 江苏春申堂药业有限公司 | Traditional Chinese medicinal preparation for treating intractable leukoplakia vulvae of woman |
| CN104490959B (en) * | 2014-12-29 | 2018-02-13 | 江苏春申堂药业有限公司 | Treat the Chinese medicine preparation of women intractable leukoplakia vulvae |
| CN104857468A (en) * | 2015-05-13 | 2015-08-26 | 四川金堂海纳生物医药技术研究所 | Leukoplakia vulvae treating medicine for oral administration and preparation method thereof |
| CN108815274A (en) * | 2018-07-25 | 2018-11-16 | 博凯健康产业有限公司 | Clean maintenance bacteriostatic gel of woman and its preparation method and application |
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