CN104857468A - Leukoplakia vulvae treating medicine for oral administration and preparation method thereof - Google Patents

Abstract

Provided are leukoplakia vulvae treating medicine for oral administration and a preparation method thereof. The leukoplakia vulvae treating medicine for oral administration comprises, by mass, ingredients including 1-3 parts of sophora flavescens, 1-3 parts of fructus cnidii, 1-3 parts of felwort, 1-3 parts of cape jasmine cores, 1-3 parts of common peony roots, 1-3 parts of Chinese angelica, 1-3 parts of cortex dictamni, 1-3 parts of tribulus terrestris, 1-3 parts of fresh ginger peel and 1-3 parts of fresh liquorice. The preparation method of the medicine comprises the following steps of (A) selecting first-class sophora flavescens, the fructus cnidii, the felwort, the cape jasmine cores, the common peony roots, the Chinese angelica, the cortex dictamni, the tribulus terrestris, the fresh ginger peel and the fresh liquorice by parts of mass and respectively removing impurities and dust and then putting the ingredients into a cloth bag and binding a bag opening standby application, (B) putting the ingredients into clear water to be soaked for about half an hour till the ingredients are soaked completely, then putting the well soaked ingredients into a decocting machine, adding cold boiled water 30 mm higher than water level to perform first-time decoction for 35 minutes, filtering medicine liquid, adding slightly warm boiled water again to perform second-time decoction for 35 minutes, performing mixing and concentration to form 50% Chinese traditional medicine liquid 1620 ml, bagging and sealing the medicine liquid and then putting the medicine liquid into a refrigerator for preservation and standby application.

Description

A kind of endo-medicine for the treatment of leukoplakia vulvae and preparation method thereof

Technical field

The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of endo-medicine for the treatment of leukoplakia vulvae, particularly for the field of the endo-medicine and preparation method thereof of female genitalia leukoplakia patient.

Background technology

Leukoplakia vulvae (leukoplakia vulvae) is also known as vulvar dystrophy, in fact refer to the tissue degeneratiaon that pudendum local nerve and angiodystrophia cause and discolored a kind of disease, the skin and the mucosa that comprise pudendum local bleach thicker or atrophic disease.There is limitation or diffusivity white speckle in patient's genital skin, can spread to two preaxials, perineum and anus, patient often feels pudendal pruritus, xerosis cutis, follows the string, even atrophy ulceration, has obvious pain and burn feeling.Morbidity is infected with endocrine disturbance, pudendum, inflammatory stimulus, inherited genetic factors, pudendum Local physical stimulates and the other diseases such as diabetes, vitiligo, vulval eczema is relevant.Leukoplakia vulvae belongs to the category such as Chinese medicine " pudendal pruritus ", " cloudy pain ", " pain over the perineum ", and the traditional Chinese medical science is thought: its morbidity is many because of dampness-heat of the liver bet, dipping pudendum, or the essence and blood such as blood-deficiency leading to hyperactivity of the liver, the hepatic and renal YIN deficiency, kidney yang deficiency can not moisten caused by foster pudendum.

So, just how finding a kind of endo-medicine effectively can treating above-mentioned leukoplakia vulvae, is our current problem in urgent need to solve.

Summary of the invention

The object of this invention is to provide a kind of endo-medicine for the treatment of leukoplakia vulvae and preparation method thereof, to solve leukoplakia vulvae patient restorative problem early.This medicine is that have compatibility science, the efficacy of a drug is powerful with common Chinese herbal medicine for raw material, has fully demonstrated liver heat removing dampness removing, and dispel the wind the Therapeutic Principle relieved internal heat.

For reaching the object of foregoing invention, the technical solution adopted in the present invention is: provide a kind of endo-medicine for the treatment of leukoplakia vulvae and preparation method thereof, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Radix Sophorae Flavescentis 1-3 part;

Fructus Cnidii 1-3 part;

Radix Gentianae 1-3 part;

Fructus Gardeniae core 1-3 part;

Radix Paeoniae Rubra 1-3 part;

Radix Angelicae Sinensis 1-3 part;

Cortex Dictamni 1-3 part;

Fructus Tribuli 1-3 part;

CORTEX ZINGIBERIS RHIZOMAE 1-3 part;

Radix Glycyrrhizae 1-3 part.

According to the endo-medicine for the treatment of leukoplakia vulvae provided by the present invention, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Radix Sophorae Flavescentis 1 part;

Fructus Cnidii 1 part;

Radix Gentianae 1 part;

Fructus Gardeniae core 1 part;

Radix Paeoniae Rubra 1 part;

Radix Angelicae Sinensis 1 part;

Cortex Dictamni 1 part;

Fructus Tribuli 1 part;

CORTEX ZINGIBERIS RHIZOMAE 1 part;

Radix Glycyrrhizae 1 part.

A kind of endo-medicine for the treatment of leukoplakia vulvae and preparation method thereof, is characterized in that, described method comprises the steps:

A, the one-level Radix Sophorae Flavescentis 1 part selecting high-quality clean, Fructus Cnidii 1 part, Radix Gentianae 1 part, Fructus Gardeniae core 1 part, Radix Paeoniae Rubra 1 part, Radix Angelicae Sinensis 1 part, Cortex Dictamni 1 part, Fructus Tribuli 1 part, CORTEX ZINGIBERIS RHIZOMAE 1 part, Radix Glycyrrhizae 1 part, enter cloth bag tying stand-by after picking decontamination and dust respectively;

B, said medicine put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into boiling machine, the cold boiled water injecting medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, mixing is condensed into the herb liquid 1620 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed sealing.

A kind of endo-medicine for the treatment of leukoplakia vulvae and preparation method thereof, is characterized in that, described instructions of taking is: divided by the herb liquid prepared and take for three days, every day potion, the morning, noon and afternoon service once, dosage 180 milliliters/time, (medicine) being taken before meal.Take medicine 26-29 agent, disease is cured.

Medicine provided by the present invention is oral traditional Chinese medicine composition, and it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Radix Sophorae Flavescentis, nature and flavor: bitter in the mouth, cold in nature, have effect of heat clearing and damp drying, wind dispelling insecticide, are used for the treatment of damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, leprosy, skin pruritus, noxious dampness skin infection etc.;

Fructus Cnidii, nature and flavor: acrid, bitter, warm, have warming the kidney to activate YANG, dispel the wind, effect of dampness, parasite killing, and be used for the treatment of impotence in male, scrotum pruritus due to damp pathogen, woman's leukorrhagia pudendal pruritus, cold uterus is infertile, rheumatic arthralgia, scabies eczema;

Radix Gentianae, nature and flavor: bitter cold, have liver heat removing gallbladder excess-fire, rush down effect of damp-heat in lower-JIAO, are used for the treatment of the diseases such as the day red dizziness of dampness-heat in the liver and gallbladder stagnated fire, deafness, ear are swollen, the tic of hypochondriac pain bitter taste, infantile convulsion, damp and hot sore;

Fructus Gardeniae core, nature and flavor: bitter, cold, fruit: the effect with pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body, be used for the treatment of that calentura is vexed, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tell nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles, external treatment bruise pain, root: eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis, for infectious hepatitis, traumatic injury, acute toothache;

Radix Paeoniae Rubra, nature and flavor: bitter, be slightly cold, have effect of clearing away heat and cooling blood, eliminating stasis to stop pain, are used for the treatment of maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection;

Radix Angelicae Sinensis, nature and flavor:, warm in nature, sweet in the mouth is pungent, there is benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturize effect of laxation, be used for the treatment of blood deficiency, shallow complexion, dizzy cardiopalmus, blood deficiency or have the pain cards such as the stagnant menoxenia of the stasis of blood, amenorrhea, dysmenorrhea, deficient cold type stomachache, angina pectoris, rheumatic arthralgia, traumatic injury concurrently;

Cortex Dictamni, nature and flavor: cold in nature, bitter in the mouth, have heat clearing and damp drying, the effect of removing toxic substances of dispeling the wind, and are used for the treatment of that eczema, damp and hot sore, yellow fluid are dripping, the disease such as scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice dark coloured urine;

Fructus Tribuli, nature and flavor: bitter in the mouth, pungent, property are put down, and have effect of suppressing the hyperactive liver, resolving depression, dispelling pathogenic wind for improving eyesight, are used for the treatment of headache, dizzy, distending pain in the chest and hypochondrium, distending pain of the breast, breast close obstructed, amenorrhea, cataract, rubella pruritus, vitiligo, skin ulcer cellulitis, scrofula;

CORTEX ZINGIBERIS RHIZOMAE, nature and flavor: acrid in the mouth, cool in nature, have effect of line water detumescence, are used for the treatment of edema from the beginning of, dysuria;

Radix Glycyrrhizae, nature and flavor: sweet, flat, there is effect of invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, be used for the treatment of weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

When taking, the herb liquid prepared is divided and within three days, takes, every day potion, the morning, noon and afternoon service once, dosage 180 milliliters/time, (medicine) being taken before meal.Take medicine 26-29 agent, disease is cured.This medicine is that have compatibility science, the efficacy of a drug is powerful with common Chinese herbal medicine for raw material, has fully demonstrated liver heat removing dampness removing, and dispel the wind the Therapeutic Principle relieved internal heat.

Detailed description of the invention

Below embodiments of the present invention are described in detail

Leukoplakia vulvae (leukoplakia vulvae) is also known as vulvar dystrophy, in fact refer to the tissue degeneratiaon that pudendum local nerve and angiodystrophia cause and discolored a kind of disease, the skin and the mucosa that comprise pudendum local bleach thicker or atrophic disease.There is limitation or diffusivity white speckle in patient's genital skin, can spread to two preaxials, perineum and anus, patient often feels pudendal pruritus, xerosis cutis, follows the string, even atrophy ulceration, has obvious pain and burn feeling.Morbidity is infected with endocrine disturbance, pudendum, inflammatory stimulus, inherited genetic factors, pudendum Local physical stimulates and the other diseases such as diabetes, vitiligo, vulval eczema is relevant.Leukoplakia vulvae belongs to the category such as Chinese medicine " pudendal pruritus ", " cloudy pain ", " pain over the perineum ", and the traditional Chinese medical science is thought: its morbidity is many because of dampness-heat of the liver bet, dipping pudendum, or the essence and blood such as blood-deficiency leading to hyperactivity of the liver, the hepatic and renal YIN deficiency, kidney yang deficiency can not moisten caused by foster pudendum.

The present invention is exactly treatment for above-mentioned leukoplakia vulvae and a kind of Chinese herbal medicine formula proposed, and adopts herb liquid prepared by this formula, good drug efficacy, instant effect, effectively can treat leukoplakia vulvae.Below specific embodiment provided by the present invention is described in detail.

Embodiment 1:

The one-level Radix Sophorae Flavescentis 15 grams selecting high-quality clean, Fructus Cnidii 10 grams, Radix Gentianae 10 grams, Fructus Gardeniae core 10 grams, Radix Paeoniae Rubra 12 grams, Radix Angelicae Sinensis 10 grams, Cortex Dictamni 10 grams, Fructus Tribuli 15 grams, CORTEX ZINGIBERIS RHIZOMAE 3 grams, Radix Glycyrrhizae 3 grams, enter cloth bag tying stand-by after picking decontamination and dust respectively; Said medicine is put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into boiling machine, the cold boiled water injecting medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, mixing is condensed into the herb liquid 1620 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed sealing.When taking, the herb liquid prepared is divided and within two days, takes, every day potion, the morning, noon and afternoon service once, dosage 180 milliliters/time, (medicine) being taken before meal.Take medicine 26-29 agent, disease is cured.

Embodiment 2:

The one-level Radix Sophorae Flavescentis 16 grams selecting high-quality clean, Fructus Cnidii 11 grams, Radix Gentianae 11 grams, Fructus Gardeniae core 11 grams, Radix Paeoniae Rubra 13 grams, Radix Angelicae Sinensis 11 grams, Cortex Dictamni 11 grams, Fructus Tribuli 16 grams, CORTEX ZINGIBERIS RHIZOMAE 3.5 grams, Radix Glycyrrhizae 3.5 grams, enter cloth bag tying stand-by after picking decontamination and dust respectively; Said medicine is put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into boiling machine, the cold boiled water injecting medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, mixing is condensed into the herb liquid 1620 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed sealing.When taking, the herb liquid prepared is divided and within two days, takes, every day potion, the morning, noon and afternoon service once, dosage 180 milliliters/time, (medicine) being taken before meal.Take medicine 26-27 agent, disease is cured.

Embodiment 3:

The one-level Radix Sophorae Flavescentis 15 grams selecting high-quality clean, Fructus Cnidii 10 grams, Radix Gentianae 10 grams, Fructus Gardeniae core 10 grams, Radix Paeoniae Rubra 12 grams, Radix Angelicae Sinensis 10 grams, Cortex Dictamni 10 grams, Fructus Tribuli 15 grams, CORTEX ZINGIBERIS RHIZOMAE 3 grams, Radix Glycyrrhizae 3 grams, enter cloth bag tying stand-by after picking decontamination and dust respectively; Said medicine is put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into boiling machine, the cold boiled water injecting medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, mixing is condensed into the herb liquid 1620 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed sealing.When taking, the herb liquid prepared is divided and within two days, takes, every day potion, the morning, noon and afternoon service once, dosage 180 milliliters/time, (medicine) being taken before meal.Take medicine 26-28 agent, disease is cured.

The present invention is through the treatment to nearly one hundred routine patient, and therapeutic effect is remarkable, has no side effect, and part allusion quotation shape case is as follows.

1, patient: Qiu XX, female, 35 years old, address: Sichuan Province's Deyang City

Illness symptom: patient's readme: external genital pruritus more than year, and is shown in vagina words spoken by an actor from offstage liquid permanent current.Over nearly three months, pudendum fever, redness, swelling and pain, very itches unbearably, especially with on the right side of pudendum for work.Suspected of " leukoplakia vulvae " after the examination in hospital of town, thereafter certain hospital attached to a medical college is turned, find through gynecologial examination: inside the labium majus of right side visible one Semen phaseoli radiati size white speckle, local skin is coarse, hardening, in have blind crack, touch sufferings aggravation, periphery red swelling of the skin, and see multiple vesicle, have no purulent secretion and cover, come off without squama, vaginal smear examination is normal.Biopsy report " leukoplakia vulvae " is got in its pudendum lump portion.Once repeatly in order to Chinese and western drugs treatment, curative effect was had no.Examine its uneasy in either sitting or lying, expression is painful, pulse condition stringy and rolling pulse band number, red tongue, yellow and greasy fur.This is that pathogenic wind toxic is damp and hot, accumulates into long-pending for a long time, under the son of note, for vaginal orifice pruritus also.Control suitable liver heat removing dampness removing, dispel the wind and relieve internal heat.

Treatment: side, with inside and outside double smelting, gives top " herb liquid " and takes orally, " pudendal pruritus washout side " external.Medication 5 days, pudendum local Hong Zhong inflammation heat disappears gradually, and pain of itching also subtracts greatly, and sitting and lying is gradually pacified.Pulse condition stringy and rolling pulse, red tongue, yellow and thin fur.Continue with top, it adds Rhizoma Coptidis 6g in Fang Zhongzai for oral administration, separately decocts and takes.Treated for more than 20 days again, pudendal pruritus removes to the greatest extent, and swell and ache and also disappear, disease is cured.Visit 3 year, do not recurred again, healthy.

2, patient: Zhu XX, female, 39 years old, address: Ziyang City, Sichuan Province

Illness symptom: nearly 2 years of external genital pruritus, and see vagina words spoken by an actor from offstage liquid permanent current.It is near that pudendum fever, redness, swelling and pain, very itches unbearably for a period of time, especially with on the left of pudendum for work.Suspected of leukoplakia vulvae after county hospital checks, thereafter the People's Hospital of Zhuan Mou city treatment, find through gynecologial examination: inside the labium majus of left side, visible Semen phaseoli radiati size white speckle is several, and local skin is coarse, hardening, in have blind crack, touch sufferings more so, periphery red swelling of the skin, visible multiple vesicle, has no purulent secretion and covers, come off without squama, vaginal smear examination is normal.Biopsy report " leukoplakia vulvae " is got in its pudendum lump portion.Once repeatly in order to Chinese and western drugs treatment, curative effect was had no.Examine its uneasy in either sitting or lying, expression is painful, pulse condition stringy and rolling pulse band number, red tongue, yellow and greasy fur.This is that pathogenic wind toxic is damp and hot, accumulates into long-pending for a long time, under the son of note, for vaginal orifice pruritus also.

Treatment: side, with inside and outside double smelting, gives top " herb liquid " and takes orally, " pudendal pruritus washout side " external.Medication 8 days, pudendum local Hong Zhong inflammation heat disappears gradually, and pain of itching also subtracts more than half, and sitting and lying is gradually pacified.Pulse condition stringy and rolling pulse, red tongue, yellow and thin fur.Continue with top, it adds Rhizoma Coptidis 7g in Fang Zhongzai for oral administration, separately decocts and takes.Treat 25 again, pudendal pruritus all removes, and swell and ache and all disappear, disease obtains recovery from illness.5 years are visited, no abnormality seen.

Claims (3)

1. treat an endo-medicine for leukoplakia vulvae, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Radix Sophorae Flavescentis 1-3 part;

Fructus Cnidii 1-3 part;

Radix Gentianae 1-3 part;

Fructus Gardeniae core 1-3 part;

Radix Paeoniae Rubra 1-3 part;

Radix Angelicae Sinensis 1-3 part;

Cortex Dictamni 1-3 part;

Fructus Tribuli 1-3 part;

CORTEX ZINGIBERIS RHIZOMAE 1-3 part;

Radix Glycyrrhizae 1-3 part.

2. the endo-medicine for the treatment of leukoplakia vulvae according to claim 1, is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Radix Sophorae Flavescentis 1 part;

Fructus Cnidii 1 part;

Radix Gentianae 1 part;

Fructus Gardeniae core 1 part;

Radix Paeoniae Rubra 1 part;

Radix Angelicae Sinensis 1 part;

Cortex Dictamni 1 part;

Fructus Tribuli 1 part;

CORTEX ZINGIBERIS RHIZOMAE 1 part;

Radix Glycyrrhizae 1 part.

3. endo-medicine of the treatment leukoplakia vulvae described in a claim 1 or 2 and preparation method thereof, is characterized in that, described method comprises the steps:

A, according to mass parts than selecting the clean one-level Radix Sophorae Flavescentis of high-quality, Fructus Cnidii, Radix Gentianae, Fructus Gardeniae core, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Cortex Dictamni, Fructus Tribuli, CORTEX ZINGIBERIS RHIZOMAE, Radix Glycyrrhizae, enter cloth bag tying after picking decontamination and dust respectively stand-by;

B, said medicine put into about water purification soaks half an hour, with osmotic drug degree of being organized as, then more soaked medicine is put into boiling machine, the cold boiled water injecting medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, re-inject tepor boiled water and carry out second time decoction 30 minutes, mixing is condensed into the herb liquid 1620 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed sealing.