CN103432486B - Traditional Chinese medicine composition for treating leukoplakia vulvae - Google Patents
Traditional Chinese medicine composition for treating leukoplakia vulvae Download PDFInfo
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- CN103432486B CN103432486B CN201310211912.9A CN201310211912A CN103432486B CN 103432486 B CN103432486 B CN 103432486B CN 201310211912 A CN201310211912 A CN 201310211912A CN 103432486 B CN103432486 B CN 103432486B
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Abstract
The invention discloses a traditional Chinese medicine composition for treating leukoplakia vulvae. Within effective dosages, the traditional Chinese medicine composition is composed by the following components of cortex phellodendri, radix sophorae flavescentis, fructus cnidii, radix stemonae, divaricate saposhnikovia root, cotex dictamni, dried alum, borneol and realgar. The invention also relates to the application of the traditional Chinese medicine composition in preparing drugs for treating leukoplakia vulvae, for preventing trichomonas vaginalis and for preventing vaginal fungal infections. Preparations of the drugs traditional Chinese medicine composition comprise suppository and lotion. The traditional Chinese medicine composition provided by the invention has an effective rate of 100%, and is high in curative rate and fast in efficiency.
Description
Technical field
The invention belongs to tcm field, particularly treat the Chinese medicine of vagina disease.
Background technology
Leukoplakia vulvae, has another name called leukoplakia vulvae, points out limitation or the diffusivity white speckle of present women's genital skin, can spread, but seldom invade urethral orifice and vestibule to two preaxials, perineum and anus.Disease sees pudendal pruritus, xerosis cutis, and plumpness bleaches, and follows the string, even atrophy ulceration, has pain and burn feeling.Leukoplakia vulvae is again white diseases of vulva, leukoplakia vulvae or vulvar dystrophy.In fact so-called leukoplakia vulvae refers to the tissue degeneratiaon that pudendum local nerve and angiodystrophia cause and discolored disease.Usually the skin of pudendum local and mucosa are bleached thicker or atrophic disease clinically, be referred to as " leukoplakia vulvae ".Clinical pathology inspection has atypical cell to increase survivor to belong to Chinese medicine " pudendal pruritus " " pudendum the moon pain " " pain over the perineum " category, how because stain pudendum is invaded in dampness-heat of the liver bet, or blood-deficiency leading to hyperactivity of the liver, the essence and blood such as the hepatic and renal YIN deficiency, kidney yang deficiency can not moisten caused by foster pudendum.The patient suffering from leukoplakia vulvae has the Symptoms appearance of pruritus vulvae, sometimes can also have scorching hot, pain.The type of leukoplakia vulvae has a lot, comprise constitutional atrophy of vulva, atrophic sclerosis lichen, leukoplakia vulvae, white macula vaginitis, pudendum dry up etc. usually skin is bleached with mucosa clinically, thicker become the vulvopathy of atrophy be referred to as leukoplakia vulvae.The traditional Chinese medical science is called cloudy moss, the erosion of vulva, the erosion of the vulva, pain over the perineum leukoplakia vulvae, and leukoplakia vulvae or a kind of precancerous lesion.
Application number is the Chinese invention patent application of 201110461191.8, describe with Rhizoma Polygoni Cuspidati, Flos Carthami, Radix Arnebiae (Radix Lithospermi), Cortex Phellodendri, Radix Sophorae Flavescentis, Herba speranskiae tuberculatae, Borneolum Syntheticum treatment leukoplakia vulvae, its Main Function is blood circulation promoting and blood stasis dispelling, anti-inflammation, antipruritic, expelling wind and removing dampness, heat-clearing and toxic substances removing, analgesia detumescence, strengthens cutaneous circulation, has and promotes subcutaneous elastic object.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Chinese medicine composition, this Chinese medicine composition is intended to treatment vagina white macula.Two of object of the present invention is the preparation providing described Chinese medicine composition, and said preparation is easy to use, successful.Three of object of the present invention is the preparation method providing described preparation, and the method program is simple, is suitable for large-scale production.
For achieving the above object, technical scheme of the present invention is:
Chinese medicine composition, is characterized in that: composed of the following components in effective dose: Cortex Phellodendri, Radix Sophorae Flavescentis, Fructus Cnidii, white portion, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum, Realgar.Described effective dose, refers to this area routine administration dosage, specifically can refer to the dosage mentioned in " Chinese Pharmacopoeia " or " Chinese medicine voluminous dictionary ".
Preferably, described Chinese medicine composition, described Chinese medicine composition is composed of the following components by weight:
Cortex Phellodendri 180-220 part,
Radix Sophorae Flavescentis 180-220 part,
Fructus Cnidii 180-220 part,
White portion 180-220 part,
Radix Saposhnikoviae 80-120 part,
Favus skin 28-33 part,
Dried Alumen 180-220 part,
Borneolum Syntheticum 22-28 part,
Realgar 13-18 part.
Preferably, described Chinese medicine composition, described Chinese medicine composition is composed of the following components by weight:
Cortex Phellodendri 200 parts,
Radix Sophorae Flavescentis 200 parts,
Fructus Cnidii 200 parts,
200 parts, white portion,
Radix Saposhnikoviae 100 parts,
Favus skin 30 parts,
Dried Alumen 200 parts,
Borneolum Syntheticum 25 parts,
Realgar 15 parts,
Preferably, described Chinese medicine composition, is characterized in that, also comprises Mentholum in described Chinese medicine composition, and the weight of described Mentholum is equivalent to the 1/50-1/25 of described dried Alumen weight.Described Mentholum adds when preparing lotion, has both possessed effect of antipruritic, antiinflammatory and pain relieving, can increase again comfort level during use.
The application of described Chinese medicine composition in the medicine of preparation treatment leukoplakia vulvae.
The application of described Chinese medicine composition in the medicine of the anti-trichomonas vaginitis of preparation.
The application of described Chinese medicine composition in the medicine of the anti-vagina fungal infection of preparation.
The preparation of described Chinese medicine composition, described preparation is suppository or lotion.
Further, the preparation method of described preparation, the dosage form of described preparation is suppository, the Cortex Phellodendri of formula ratio, Radix Sophorae Flavescentis, Fructus Cnidii, white portion, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum and Realgar is ground to form powdery, makes suppository.
Further, the preparation method of described preparation, the dosage form of described preparation is lotion, the Cortex Phellodendri of formula ratio, Radix Sophorae Flavescentis, Fructus Cnidii, white portion, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum and Realgar are ground to form powdery, abundant mixing, obtains Traditional Chinese drug mixture powder, and makes decoction liquor, in described decoction liquor, add Sal make it to become isotonic liquid, and add the Mentholum of formula ratio; Containing 8-12 gram of described Traditional Chinese drug mixture powder in every 300 milliliters of described decoction liquor.
Beneficial effect of the present invention is: in the present invention, and Cortex Phellodendri has heat clearing and damp drying under effective dose, and pathogenic fire purging removes steams, effect of detoxification sore treatment; Radix Sophorae Flavescentis has the effect of anti-inflammation under effective dose, heat clearing and damp drying.Fructus Cnidii can warming the kidney to invigorate YANG, and dampness, dispels the wind, parasite killing; White portion, nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Radix Saposhnikoviae expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic under effective dose.Favus skin has heat clearing and damp drying, the effect of removing toxic substances of dispeling the wind.Dried Alumen has expectorant,
dampness, antidiarrheal, hemostasis, effect of removing toxic substances and parasite killing.Borneolum Syntheticum has all keys, loose stagnated fire, removing nebula improving eyesight, effect of reducing swelling and alleviating pain.Realgar has parasite killing and treats skin ulcer, and relieve internal heat anticancer effect.Mentholum energy chafe mucosa, while antipruritic, antiinflammatory, pain relieving, local has cool feeling.Effective percentage 100% of the present invention, cure rate is high, rapid-action.
Detailed description of the invention
Illustrated embodiment is to be described content of the present invention better, but is not that content of the present invention is only limitted to illustrated embodiment.So those of ordinary skill in the art carry out nonessential improvement and adjustment according to foregoing invention content to embodiment, still belong to protection scope of the present invention.
The bacteriostatic experiment of embodiment 1 Chinese medicine composition
One formula and preparation thereof
Described Chinese medicine composition, described Chinese medicine composition is composed of the following components:
Cortex Phellodendri 1800g,
Radix Sophorae Flavescentis 1800g,
Fructus Cnidii 1800g,
White portion 1800g,
Radix Saposhnikoviae 1200g,
Favus skin 330g,
Dried Alumen 2200 parts,
Borneolum Syntheticum 280 parts,
Realgar 180 parts.
Each component of formula ratio is made powder, fully mixes, obtain Traditional Chinese drug mixture powder.
Two bacteriostatic experiments
1 experiment grouping: the cefradine (the accurate word H23021929 of traditional Chinese medicines, lot number 0309303) that Experimental agents selects Ha Yaosanjing pharmaceutical Co. Ltd to produce, called after cefradine group, is diluted into twice mass concentration.Above-mentioned Traditional Chinese drug mixture powder is selected to be the group called after Chinese drug-treated group of trial drug; Described Chinese drug-treated group biggest quality volumetric concentration is 8%, is diluted to 10 volume gradient concentrations, refers to table 2.Select Chongqing Hil'an Pharmaceutical Co., Ltd bacterium gram washing liquid to be Experimental agents, maximum volume diluted concentration is 1%, is diluted to 8 volume gradient concentrations, refers to table 1.
2 experimental techniques: select following three kinds of bacterium as experimental bacteria respectively, 1) staphylococcus epidermidis (Staphylococcus epidermidis), ATCC20015; 2) escherichia coli (Escherichia, e.coli), ATCC20019; 3) Candida albicans shape streptobacillus, ATCC10076.
With nutrient agar (China Inst. of Quarantine Inspection Sciences and Beijing road and bridge Technology Co., Ltd. Joint Production, lot number 041110) by solid double dilution method dilution cefradine, make positive control medicine.With reference to the bacteriostatic experiment in " Chinese Pharmacopoeia ", observation cefradine group, bacterium gram washing liquid group (each Concentraton gradient) and decoction liquor (each Concentraton gradient) each experimental bacteria growing state on nutrient agar panel must obtain the minimum inhibitory concentration (MIC) of medicine; Or.And blank group is set.Experimental result refers to table 1 and table 2.
Table 1 bacterium must gram washing liquid bacteriostatic experiment result
| Drug level (%) | Staphylococcus epidermidis | Escherichia coli | Candida albicans shape streptobacillus |
| 1.0 | - | -① | -① |
| 0.5 | - | + | + |
| 0.25 | -① | + | + |
| 0.125 | + | + | + |
| 0.0625 | + | + | + |
| 0.03125 | + | + | + |
| o.015625 | + | + | + |
| 0.0078125 | + | + | + |
| Cefradine group | - | - | - |
| Positive bacteria growth control group | + | + | + |
| Blank group | - | - | - |
+ long bacterium;-not long bacterium; 1. minimum inhibitory concentration.
Table 2 Traditional Chinese drug mixture powder bacteriostatic experiment result
+ long bacterium;-not long bacterium; 1. minimum inhibitory concentration; The concentration of Traditional Chinese drug mixture powder is mass body volume concentrations.
As can be seen from Table 1 and Table 2, cefradine group, positive bacteria growth group, blank group are all set up; Bacterium must gram washing liquid be 0.25% to the staphylococcic minimum inhibitory concentration of epidermis, is 1.0% to the minimum inhibitory concentration of escherichia coli, Candida albicans shape streptobacillus.Described Traditional Chinese drug mixture powder is 1.0% to the staphylococcic minimum inhibitory concentration of epidermis, is 2.0% to the minimum inhibitory concentration of escherichia coli, Candida albicans shape streptobacillus.
Embodiment 2 is used for the treatment of the medicine of vagina fungal infection
Described Chinese medicine composition, described Chinese medicine composition is by composed of the following components:
Cortex Phellodendri 2200g,
Radix Sophorae Flavescentis 2200g,
Fructus Cnidii 2200g,
White portion 2200g,
Radix Saposhnikoviae 800g,
Favus skin 280g,
Dried Alumen 1800g,
Borneolum Syntheticum 220g,
Realgar 130g.
By above-mentioned each component grind into powder, abundant mix homogeneously, gets 100 grams of mixed powder as mainly.Accompany and add certain adjuvant and be prepared into suppository.Intravaginal filled in by suppository, within every two days one, changes.Treatment is implemented to 60 routine fungal infection patients, effective percentage 100%, wherein cure rate 80%.
Embodiment 3 is used for the treatment of the medicine of vagina white macula
Described Chinese medicine composition, described Chinese medicine composition is composed of the following components:
Cortex Phellodendri 2000g,
Radix Sophorae Flavescentis 2000g,
Fructus Cnidii 2000g,
White portion 2000g,
Radix Saposhnikoviae 1000g,
Favus skin 300g,
Dried Alumen 2000g,
Borneolum Syntheticum 250g,
Realgar 150g,
Mentholum 66g.
Each component of formula ratio is made powder, fully mixes, obtain Traditional Chinese drug mixture powder, and make decoction liquor, in described decoction liquor, add Sal make it to become isotonic liquid; Containing 10 grams of described Traditional Chinese drug mixture powder in every 300 milliliters of described decoction liquor.Described decoction liquor is as vaginal lotion.100 vagina white macula patients adopt this medicine to carry out vagina cleaning.Wherein, a cleaning in three days every 4 hours once.After three days, 100 patients all feel that symptom alleviates.Medication, after three days, changes every 6 hours into once, continues 4 days; Within 8th day every 12 hours, use once.The cure rate of vagina white macula patient is 90%.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (8)
1. Chinese medicine composition, is characterized in that: composed of the following components in effective dose, composed of the following components by weight:
2. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition is composed of the following components by weight:
3. the application of the Chinese medicine composition described in any one of claim 1-2 in the medicine of preparation treatment leukoplakia vulvae.
4. the application of the Chinese medicine composition described in any one of claim 1-2 in the medicine of the anti-trichomonas vaginitis of preparation.
5. the application of the Chinese medicine composition described in any one of claim 1-2 in the medicine of the anti-vagina fungal infection of preparation.
6. the preparation of the Chinese medicine composition described in any one of claim 1-2, is characterized in that, described preparation is suppository or lotion.
7. the preparation method of preparation according to claim 6, the dosage form of described preparation is suppository, it is characterized in that: the Cortex Phellodendri of formula ratio, Radix Sophorae Flavescentis, Fructus Cnidii, white portion, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum, Realgar and Mentholum are ground to form powdery, makes suppository.
8. the preparation method of preparation according to claim 6, the dosage form of described preparation is lotion, it is characterized in that: the Cortex Phellodendri of formula ratio, Radix Sophorae Flavescentis, Fructus Cnidii, white portion, Radix Saposhnikoviae, favus skin, dried Alumen, Borneolum Syntheticum, Realgar and Mentholum are ground to form powdery, abundant mixing, obtain Traditional Chinese drug mixture powder, and make decoction liquor, in described decoction liquor, add Sal make it to become isotonic liquid, and add the Mentholum of formula ratio; Containing 8-12 gram of described Traditional Chinese drug mixture powder in every 300 milliliters of described decoction liquor.
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| CN104490959B (en) * | 2014-12-29 | 2018-02-13 | 江苏春申堂药业有限公司 | Treat the Chinese medicine preparation of women intractable leukoplakia vulvae |
| CN104857468A (en) * | 2015-05-13 | 2015-08-26 | 四川金堂海纳生物医药技术研究所 | Leukoplakia vulvae treating medicine for oral administration and preparation method thereof |
| CN108815274A (en) * | 2018-07-25 | 2018-11-16 | 博凯健康产业有限公司 | Clean maintenance bacteriostatic gel of woman and its preparation method and application |
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| CN1059346C (en) * | 1995-04-11 | 2000-12-13 | 孔繁营 | Chinese herb medicine for external use of gynecopathy |
| CN1193526A (en) * | 1997-03-14 | 1998-09-23 | 冯利军 | 'Fukangjieyin' powder for health of women pudenda and preparation thereof |
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