CN108815257A - Clean compact bacteriostatic gel of woman and its preparation method and application - Google Patents
Clean compact bacteriostatic gel of woman and its preparation method and application Download PDFInfo
- Publication number
- CN108815257A CN108815257A CN201810844128.4A CN201810844128A CN108815257A CN 108815257 A CN108815257 A CN 108815257A CN 201810844128 A CN201810844128 A CN 201810844128A CN 108815257 A CN108815257 A CN 108815257A
- Authority
- CN
- China
- Prior art keywords
- gel
- woman
- extract
- parts
- compact
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/638—Ligustrum, e.g. Chinese privet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Insects & Arthropods (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Inorganic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides clean compact bacteriostatic gel of a kind of woman and its preparation method and application, it is related to Amino-Cerv technical field, in the clean compact bacteriostatic gel of woman, every 100g gel includes Chinese medical extract 1-3g, borneol 0.5-1.5g, chlorhexidine acetate 0.03-0.09g, surplus are water；Wherein, the Chinese medical extract includes glossy privet fruit extract, smoked plum extractive, safflower extract, nutgall extractive and Honegsukle flower P.E, improve women with age, the balance environment of the destruction vagina such as sexual life or fertility, lead to gynaecological imflammation or vagina muscles relaxation, influence the technical problem of women physical and mental health, the clean compact bacteriostatic gel of woman provided by the invention can not only effectively inhibit the growth and breeding of bacterium, and vaginal mucosa and cervical lesions can be repaired, vagina can also be promoted to restore elasticity simultaneously compact, protect ovary, improve immunity of organisms, promote female reproductive health.
Description
Technical field
The present invention relates to Amino-Cerv technical fields, more particularly, to clean compact bacteriostatic gel of a kind of woman and preparation method thereof
And application.
Background technique
Vagina is the connection inside and outside phallic very important pipeline of women, and upper end is connect with uterus, and lower end is yin
Road junction is an open cavity, is the important Tiny ecosystem area of women, and microenvironment is complicated and unstable.The cuticula of vagina
Than relatively thin, crinite protection, there are also sweat glands and special sebum body of gland, maintain vaginocutaneous pH value and lubrication
Property.With the growth of female age, sexual life or fertility etc. can destroy the balance environment of vagina, lead to bacteria breed, cause
Gynaecological imflammation and vagina muscles relaxation, influence the physical and mental health of women.
In view of this, the present invention is specifically proposed.
Summary of the invention
One of the objects of the present invention is to provide a kind of clean compact bacteriostatic gels of woman, to improve women with age,
Sexual life or fertility etc. destroy the balance environment of vagina, lead to gynaecological imflammation or vagina muscles relaxation, influence women physical and mental health
The technical issues of.
The clean compact bacteriostatic gel of woman provided by the invention, every 100g gel include Chinese medical extract 1-3g, borneol 0.5-
1.5g, chlorhexidine acetate 0.03-0.09g, surplus are water；Wherein, the Chinese medical extract includes that glossy privet fruit extract, dark plum mention
Take object, safflower extract, nutgall extractive and Honegsukle flower P.E.
Further, every 100g gel includes Chinese medical extract 1.5-2.5g, borneol 0.8-1.2g, chlorhexidine acetate
0.04-0.08g, surplus are water.
Further, every 100g gel includes Chinese medical extract 1.8-2.2g, borneol 0.9-1.1g, chlorhexidine acetate
0.05-0.07g, surplus are water.
Further, the Chinese medical extract mainly includes following component according to the mass fraction：Glossy privet fruit extract 20-
30 parts, 20-30 parts of nutgall extractive, 10-20 parts of smoked plum extractive, 10-20 parts of safflower extract and Honegsukle flower P.E 15-
25 parts；
Preferably, the Chinese medical extract mainly includes following component according to the mass fraction：Glossy privet fruit extract 22-28
Part, 22-28 part of nutgall extractive, 12-18 parts of smoked plum extractive, 12-18 parts of safflower extract and Honegsukle flower P.E 18-22
Part.
Further, every 100g gel further includes fibroin peptide 1.5-2.5g and seaweed peptide 1.5-2.5g；
Preferably, every 100g gel includes fibroin peptide 1.8-2.2g and seaweed peptide 1.8-2.2g.
Further, the clean compact bacteriostatic gel of the woman further includes auxiliary material；
Preferably, every 100g gel includes auxiliary material 3-10g；
Preferably, the auxiliary material includes at least one of thickener, moisturizer and cosolvent；
Preferably, the thickener is carbomer；
Preferably, the moisturizer is glycerol；
Preferably, the cosolvent is ethyl alcohol.
Preferably, every 100g gel includes glycerol 3-8g, carbomer 0.5-2g and ethyl alcohol 1-3g；
Preferably, every 100g gel includes glycerol 4-6g, carbomer 1-1.5g and ethyl alcohol 1.5-2.5g.
The second object of the present invention is to provide a kind of preparation method of clean compact bacteriostatic gel of woman, include the following steps：
By Chinese medical extract, borneol, chlorhexidine acetate, optional fibroin peptide, optional seaweed peptide and optionally auxiliary
Material is dissolved in water, and is uniformly mixed, is obtained the clean compact bacteriostatic gel of woman.
Further, the preparation method of the clean compact bacteriostatic gel of the woman includes the following steps：
(a) Chinese medical extract is dissolved in the water uniformly mixed, obtains the first solution；
(b) chlorhexidine acetate and borneol are dissolved in ethyl alcohol, are uniformly mixed, obtain the second solution；
(c) carbomer is dissolved in the water, emulsification uniformly, obtains third solution；
(d) the first solution, the second solution, third solution and optional fibroin peptide and optional seaweed peptide are mixed equal
It is even, obtain the clean compact bacteriostatic gel of woman.
According to the third aspect of the present invention, the present invention provides the clean compact bacteriostatic gels of above-mentioned woman in prevention and treatment gynaecological imflammation
And the application of vagina muscles relaxation aspect.
The clean compact bacteriostatic gel of woman provided by the invention passes through glossy privet fruit extract, smoked plum extractive, safflower extract, five
Times seed extract, Honegsukle flower P.E, borneol and chlorhexidine acetate mutually cooperate with, can not only effectively inhibit bacterium growth and
Breeding, and vaginal mucosa and cervical lesions can be repaired, while vagina can also be promoted to restore elastic compact, ovary is protected,
Immunity of organisms is improved, female reproductive health is promoted.
In addition, the clean compact bacteriostatic gel of woman provided by the invention does not stimulate mildly, have no toxic side effect, without being diluted,
Directly inject into intravaginal, it is more convenient to use quick.
The preparation method simple process of the clean compact bacteriostatic gel of woman provided by the invention, it is easy to operate, work can be suitable for
Industry mass production improves production efficiency.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to an aspect of the present invention, the present invention provides a kind of clean bacteriostatic gels of woman, and every 100g gel includes Chinese medicine
Extract 1-3g, borneol 0.5-1.5g, chlorhexidine acetate 0.03-0.09g, surplus are water；Wherein, the Chinese medical extract includes
Glossy privet fruit extract, smoked plum extractive, safflower extract, nutgall extractive and Honegsukle flower P.E.
In the clean compact bacteriostatic gel of woman of offer of the invention, in every 100g gel, Chinese medical extract it is typical but non-
For example 1,1.2,1.5,1.8,2,2.2,2.5,2.8 or 3g of restrictive quality.
Chinese medical extract passes through glossy privet fruit extract, smoked plum extractive, safflower extract, nutgall extractive and honeysuckle
Extract mutually cooperates with, can effective anti-inflammatory anti-itch, antibacterial bacteriostatic repairs vaginal mucosa and cervical lesions, vagina promoted to restore
Elasticity is compact, improves female organism immunity.
In the clean compact bacteriostatic gel of woman provided by the invention, in every 100g gel, borneol it is typical but non-limiting
For example 0.5,0.6,0.7,0.8,0.9,1,1.1,1.2,1.3,1.4 or 1.5g of mass fraction.
Borneol is the crystallization obtained from the resin and volatile oil of kapur, enters the heart, lung channel, has and leads to all keys, dissipates stagnated fire,
Screen improving eyesight is gone, the effect of swelling and pain relieving.
In the clean compact bacteriostatic gel of woman provided by the invention, in every 100g gel, the typical but non-limit of chlorhexidine acetate
The quality for example 0.03 of property processed, 0.035,0.04,0.045,0.05,0.055,0.06,0.065,0.07,0.075,0.08,
0.085 or 0.09g.
Chlorhexidine acetate is the efficient spectrum fungicide of biguanides, makes cellular content by changing bacterial cytoplasm membrane permeability
It leaks out and plays bactericidal effect, stronger killing effect is all had to most of Gram-positive bacillus and negative bacillus, to green
Purulence bacillus and fungi also have good killing effect.
The clean compact bacteriostatic gel of woman provided by the invention passes through glossy privet fruit extract, smoked plum extractive, safflower extract, five
Times seed extract, Honegsukle flower P.E, borneol and chlorhexidine acetate mutually cooperate with, can not only effectively inhibit bacterium growth and
Breeding, and vaginal mucosa and cervical lesions can be repaired, while vagina can also be promoted to restore elastic compact, ovary is protected,
Immunity of organisms is improved, female reproductive health is promoted.
In addition, the clean compact bacteriostatic gel of woman provided by the invention does not stimulate mildly, have no toxic side effect, without being diluted,
Directly inject into intravaginal, it is more convenient to use quick.
In the preferred embodiment of the present invention, Chinese medical extract includes following component according to the mass fraction：Female
Loyal seed extract 20-30 parts, 20-30 parts of nutgall extractive, 10-20 parts of smoked plum extractive, 10-20 parts of safflower extract and gold
15-25 parts of honeysuckle flower extract.
In the preferred embodiment of the invention, the typical but non-limiting mass fraction of glossy privet fruit extract is for example
20,21,22,23,24,25,26,27,28,29 or 30 parts.
Glossy privet fruit extract is extracted from the fruit of glossy privet and is prepared.The fruit of glossy privet is the fruit of Oleaceae plants glossy privet, is had
Replenishing vital essence to strengthen the kidney, tonifying Qi relax liver, dysmenorrhea and blood the effect of.
In the preferred embodiment of the invention, the typical but non-limiting mass fraction of nutgall extractive is for example
20,21,22,23,24,25,26,27,28,29 or 30 parts.
Nutgall extractive is extracted from Chinese gall and is prepared, Chinese gall also known as hundred worm storehouses, have convergence and it is antibacterial
Effect can be such that the tissue proteins such as skin, mucous membrane, ulcer solidify containing tannic acid, form one layer of envelope and make in convergence
With, while to staphylococcus aureus, streptococcus, Pseudomonas aeruginosa etc. by apparent antibacterial or bactericidal effect.
In the preferred embodiment of the invention, the typical but non-limiting mass fraction of smoked plum extractive is for example
10,11,12,13,14,15,16,17,18,19 or 20 parts.
Smoked plum extractive is extracted from dark plum and is prepared, dark plum alias smoked plum, is had and is inhibited smooth muscle relaxation and disease-resistant
Pathogenic microorganism effect, significantly inhibits staphylococcus aureus, shigella dysenteriae and Pseudomonas aeruginosa, while can also
Inhibit uterine cancer cells JTC-26 plants of growth.
In the preferred embodiment of the invention, the typical but non-limiting mass fraction of safflower extract is for example
10,11,12,13,14,15,16,17,18,19 or 20 parts.
Safflower extract is extracted from safflower and is prepared, and there is safflower promoting blood circulation dysmenorrhea, dissolving stasis to moisturize, and dissipates the function of swollen analgesic
Effect.
In the preferred embodiment of the invention, the typical but non-limiting mass fraction of Honegsukle flower P.E is for example
15,16,17,18,19,20,21,22,23,24 or 25 parts.
Honegsukle flower P.E is extracted from honeysuckle and is prepared, and honeysuckle effect is mainly clearing heat and detoxicating, cures mainly warm disease
Fever, toxic-heat and blood stasis and ulcer serious case of furuncle etc..Modern study proves that honeysuckle contain the pharmacological activity such as chlorogenic acid, luteolin at
Point, there is stronger willpower to various pathogens such as hemolytic streptococcus, Staphylococcus aureus, in addition can also enhance immune
Power.
Chinese medicine composition in the present invention can not only antibacterial bacteriostatic, and can swelling and pain relieving, repair vaginal mucosa, receive
Vagina muscles are held back, the physical and mental health of women is effectively facilitated.
In the preferred embodiment of the present invention, every 100g gel further includes fibroin peptide 1.5-2.5g and seaweed
Peptide 1.5-2.5g.
In the preferred embodiment of the invention, in every 100g gel, fibroin peptide it is typical but non-limiting
For example 1.5,1.6,1.7,1.8,1.9,2,2.1,2.2,2.3,2.4 or 2.5g of quality.
Fibroin peptide has the function of antitumor, anti-oxidant and whitening and softening skin.
In the preferred embodiment of the invention, in every 100g gel, the typical but non-limiting quality of seaweed peptide
It is for example 1.5,1.6,1.7,1.8,1.9,2,2.1,2.2,2.3,2.4 or 2.5g.
Seaweed peptide has significant bioactivity and pharmacological action, has the function of preventing skin aging and skin from brightening,
Interior free yl can effectively be removed.
It, can be further by the way that fibroin peptide and seaweed peptide are added in the clean compact bacteriostatic gel of woman provided by the invention
Vagina is promoted to restore to play compact, prevention and treatment skin aging, promotion female reproductive health.
In the preferred embodiment of the present invention, the clean compact bacteriostatic gel of woman further includes auxiliary material.
By the way that auxiliary material is added in the clean compact bacteriostatic gel of woman so that in manufactured gel the mixing of each raw material more
It is even, it is more convenient to use.
In the further preferred embodiment of invention, every 100g gel includes auxiliary material 3-10g.
In the preferred embodiment of the invention, in every 100g gel, the typical but non-limiting quality of auxiliary material is such as
For 3g, 3.5g, 4g, 4.5g, 5g, 5.5g, 6g, 6.5g, 7g, 7.5g, 8g, 8.5g, 9g, 9.5g or 10g
In present invention further optimization embodiment, auxiliary material includes thickener and/or moisturizer.
In present invention further optimization embodiment, thickener is carbomer.
Carbomer is acrylic resin, and with stronger hygroscopicity, carbomer is neutralized after making carboxylic ions, due to
The repulsive interaction of negative electrical charge stretches strand disperse, is in great swelling state, and have viscosity.
In the preferred embodiment of the present invention, moisturizer is glycerol.
Glycerol has stronger hygroscopicity, the moisture on skin can be allowed not distribute fastly very much, while suitably from air
Draw aqueous vapor.
In the preferred embodiment of the present invention, every 100g gel includes carbomer 0.2-1g and glycerol 3-8g.
In the preferred embodiment of the invention, in every 100g gel, the typical but non-limiting quality of carbomer
For example 0.2g, 0.3g, 0.5g, 0.6g, 0.8g, 1g, 1.1g, 1.2g, 1.3g, 1.4g, 1.5g, 1.6g, 1.8g or 2g；Glycerol
Typical but non-limiting quality for example 3g, 3.2g, 3.5g, 3.8g, 4g, 4.2g, 4.5g, 4.8g, 5g, 5.2g, 5.5g,
5.8g, 6g, 6.2g, 6.5g, 6.8g, 7g, 7.2g, 7.5g, 7.8g or 8g.
According to the second aspect of the invention, the present invention provides a kind of preparation method of the clean compact bacteriostatic gel of woman, packets
Include following steps：
By Chinese medical extract, borneol, chlorhexidine acetate, optional fibroin peptide, optional seaweed peptide and optionally auxiliary
Material is dissolved in water, and is uniformly mixed, is obtained the clean compact bacteriostatic gel of woman.
The preparation method simple process of the clean compact bacteriostatic gel of woman provided by the invention, it is easy to operate, work can be suitable for
Industry mass production improves production efficiency.
In the preferred embodiment of the present invention, the preparation method of the clean compact bacteriostatic gel of woman, specifically includes as follows
Step：
(a) Chinese medical extract is dissolved in the water uniformly mixed, obtains the first solution；
(b) chlorhexidine acetate and borneol are dissolved in dehydrated alcohol, are uniformly mixed, obtain the second solution；
(c) carbomer is dissolved in the water, emulsification uniformly, obtains third solution；
(d) the first solution, the second solution, third solution and optional seaweed peptide and optional fibroin peptide are mixed equal
It is even, obtain the clean compact bacteriostatic gel of woman.
By Chinese medical extract being dissolved in the water to obtain the first solution respectively；Chlorhexidine acetate and borneol are dissolved in nothing
In water-ethanol, the second solution is obtained；Carbomer is dissolved in the water, emulsification uniformly, obtains third solution；Again by the first solution,
Second solution, third solution and optional fibroin peptide and optional seaweed peptide are uniformly mixed, and are more advantageous to the clean compact suppression of woman
What each component mixed in bacterium gel is more uniform, and drug effect is more stable.
According to the third aspect of the present invention, the present invention provides the clean compact bacteriostatic gels of above-mentioned woman in prevention and treatment gynaecological imflammation
And the application of vagina muscles relaxation aspect.
In the present invention, gynaecological imflammation includes but is not limited to vaginitis, cervicitis and pelvic inflammatory disease.
Technical solution provided by the invention is further described below with reference to embodiment and comparative example.
Embodiment 1
A kind of clean compact bacteriostatic gel of woman is present embodiments provided, wherein every 100g gel includes Chinese medical extract 1g, ice
Piece 1.5g, chlorhexidine acetate 0.03g, glycerol 5g and carbomer 1g, surplus are water, and wherein Chinese medical extract includes that the fruit of glossy privet extracts
20 parts of object, 30 parts of nutgall extractive, 10 parts of smoked plum extractive, 20 parts and 20 parts of Honegsukle flower P.E of safflower extract.
Embodiment 2
A kind of clean compact bacteriostatic gel of woman is present embodiments provided, wherein every 100g gel includes Chinese medical extract 3g, ice
Piece 0.5g, chlorhexidine acetate 0.09g, glycerol 5g and carbomer 1g, surplus are water, and wherein Chinese medical extract includes that the fruit of glossy privet extracts
30 parts of object, 20 parts of nutgall extractive, 20 parts of smoked plum extractive, 15 parts and 15 parts of Honegsukle flower P.E of safflower extract.
Embodiment 3
A kind of clean compact bacteriostatic gel of woman is present embodiments provided, wherein every 100g gel includes Chinese medical extract 2.5g,
Borneol 0.8g, chlorhexidine acetate 0.08g, glycerol 5g and carbomer 1g, surplus are water, and wherein Chinese medical extract includes that the fruit of glossy privet mentions
Take 28 parts of object, 22 parts of nutgall extractive, 18 parts of smoked plum extractive, 20 parts and 22 parts of Honegsukle flower P.E of safflower extract.
Embodiment 4
A kind of clean compact bacteriostatic gel of woman is present embodiments provided, wherein every 100g gel includes Chinese medical extract 1.8g,
Borneol 1.1g, chlorhexidine acetate 0.05g, glycerol 5g and carbomer 1g, surplus are water, and wherein Chinese medical extract includes that the fruit of glossy privet mentions
Take 25 parts of object, 25 parts of nutgall extractive, 15 parts of smoked plum extractive, 15 parts and 20 parts of Honegsukle flower P.E of safflower extract.
Embodiment 5
A kind of clean compact bacteriostatic gel of woman is present embodiments provided, wherein every 100g gel includes Chinese medical extract 2g, ice
Piece 1g, chlorhexidine acetate 0.06g, glycerol 5g and carbomer 1g, surplus are water, and wherein Chinese medical extract includes glossy privet fruit extract
25 parts, 25 parts of nutgall extractive, 15 parts of smoked plum extractive, 15 parts and 20 parts of Honegsukle flower P.E of safflower extract.
Embodiment 6
Present embodiments provide a kind of clean compact bacteriostatic gel of woman, the present embodiment and embodiment 5 the difference is that, often
100g gel further includes fibroin peptide 1.5g and seaweed peptide 2.5g.
Embodiment 7
Present embodiments provide a kind of clean compact bacteriostatic gel of woman, the present embodiment and embodiment 5 the difference is that, often
100g gel further includes fibroin peptide 2g and seaweed peptide 2g.
Embodiment 8
A kind of clean compact bacteriostatic gel of woman is present embodiments provided, the present embodiment and the difference of embodiment 5 are that Chinese medicine mentions
Taking object includes 10 parts of glossy privet fruit extract, and 40 parts of nutgall extractive, 5 parts of smoked plum extractive, 5 parts of safflower extract and honeysuckle
40 parts of extract.
Embodiment 9
A kind of clean compact bacteriostatic gel of woman is present embodiments provided, the present embodiment and the difference of embodiment 5 are that Chinese medicine mentions
Taking object includes 40 parts of glossy privet fruit extract, and 10 parts of nutgall extractive, 35 parts of smoked plum extractive, 5 parts of safflower extract and gold and silver
10 parts of flower extract.
Embodiment 10
The preparation method for present embodiments providing a kind of clean compact bacteriostatic gel of woman, includes the following steps：
(1) by glossy privet fruit extract, nutgall extractive, smoked plum extractive, safflower extract and Honegsukle flower P.E point
It is not dissolved in the water uniformly mixed, obtains Chinese medical extract solution；
(2) chlorhexidine acetate and borneol are dissolved in dehydrated alcohol, are uniformly mixed, obtain the second solution；
(3) carbomer is dissolved in the water, emulsification uniformly, obtains third solution；
(4) the first solution, the second solution, third solution and optional fibroin peptide and optional seaweed peptide are mixed equal
It is even, obtain the clean compact bacteriostatic gel of woman.
Comparative example 1
This comparative example provides a kind of clean compact bacteriostatic gel of woman, the present embodiment and embodiment 5 the difference is that, woman
It does not include borneol in clean compact bacteriostatic gel.
Comparative example 2
This comparative example provides a kind of clean compact bacteriostatic gel of woman, the present embodiment and embodiment 5 the difference is that, woman
It does not include chlorhexidine acetate in clean compact bacteriostatic gel.
Comparative example 3
This comparative example provides a kind of clean compact bacteriostatic gel of woman, the present embodiment and embodiment 5 the difference is that, in
It does not include glossy privet fruit extract in medicament extract.
Comparative example 4
This comparative example provides a kind of clean compact bacteriostatic gel of woman, the present embodiment and embodiment 5 the difference is that, in
It does not include smoked plum extractive in medicament extract.
Comparative example 5
This comparative example provides a kind of clean compact bacteriostatic gel of woman, the present embodiment and embodiment 5 the difference is that, in
It does not include safflower extract in medicament extract.
Comparative example 6
This comparative example provides a kind of clean compact bacteriostatic gel of woman, the present embodiment and embodiment 5 the difference is that, in
It does not include nutgall extractive in medicament extract.
Comparative example 7
This comparative example provides a kind of clean compact bacteriostatic gel of woman, the present embodiment and embodiment 5 the difference is that, in
It does not include Honegsukle flower P.E in medicament extract.
The preparation method for the clean compact bacteriostatic gel of woman that comparative example 1-8 is provided is with embodiment 5, and details are not described herein.
Test example 1
The clean compact bacteriostatic gel of woman that embodiment 1-9 and comparative example 1-7 are provided is placed in 37 DEG C of insulating boxs 3 months, is protected
Relative humidity 75% is held, bacteriostasis property test is carried out, as a result shown in table 1.
The clean compact bacteriostatic gel bacteriostasis property tables of data of 1 woman of table
It is clean compact antibacterial solidifying to can be seen that woman provided by the invention for the comparison of embodiment 1-9 and blank control group from table 1
Glue can effectively inhibit the growth of Escherichia coli, staphylococcus aureus and Candida albicans, prevent microorganism from infecting again, maintain
Vagina normal flora balance, promotes female reproductive health.
From the comparison of embodiment 1-7 and comparative example 1-2 as can be seen that the clean compact bacteriostatic gel of woman that embodiment 1-5 is provided
It is mutually cooperateed with by Chinese medical extract, borneol and chlorhexidine acetate that extra fine quality matches, to Escherichia coli, Staphylococcus aureus
The inhibitory effect of bacterium and Candida albicans is more preferably.
It can be seen that from the comparison of embodiment 1-7 and embodiment 8-9 and comparative example 3-7 when in the clean compact bacteriostatic gel of woman
Chinese medical extract by the glossy privet fruit extract of extra fine quality number, nutgall extractive, smoked plum extractive, safflower extract and
When Honegsukle flower P.E coordinated, the clean compact bacteriostatic gel fungistatic effect of made woman is more preferably.
Test example 2
The female patient of gynecological disease is suffered from selected from 850, the age is 29-45 years old, is married, non-menstrual period and bosom
In the pregnancy period, it is randomly divided into 17 groups, every group of 50 people, nonspecific vaginitis (III, IV degree of vagina cleanness degree) 15 in every group is trichomonas
Vaginitis 15, colpomycosis 20, the clean compact bacteriostatic gel difference of the woman that embodiment 1-9 and comparative example 1-7 are provided
It is pushed into patient's intravaginal, once a day, is used continuously 15 days, the 16th group is blank control group, respectively symptom before and after recording medicine,
Sign, laboratory check leukorrhea routine inspection as a result, the results are shown in Table 2.
Control efficiency table of the clean compact bacteriostatic gel of 2 woman of table to vaginitis
Note：The standard of healing is clinical symptoms, sign disappearance, and nonspecific vaginitis vaginal fluid checks that cleannes exist
I-II degree, leukorrhea routine inspection pathogen are turned out cloudy；The standard of improvement is clinical symptoms, sign partial disappearance, non-specific vagina
Scorching vaginal fluid checks cleannes part in I-II degree, and leukorrhea routine inspection pathogen is turned out cloudy；Invalid standard be it is clinical,
Sign is without change, and nonspecific vaginitis vaginal fluid checks cleannes in III-IV degree, and leukorrhea routine inspection pathogen is still
For the positive.
The comparison of embodiment 1-7 and blank control group is as can be seen that the clean compact suppression of woman that embodiment 1-7 is provided from table 2
The effective percentage of bacterium gel reaches 90% or more, and cure rate also reaches 60% or more, this illustrates that woman provided by the invention is clean compact
Bacteriostatic gel can effectively inhibit and remove vaginal pathogenic, and bacterio static itching-relieving prevents microorganism from infecting again, maintain the normal bacterium of vagina
Group's balance, promotes vagina to restore normal physiological context.
From table 2, the comparison of embodiment 1-7 and comparative example 1-2 are as can be seen that the clean compact suppression of woman that embodiment 1-7 is provided
Chinese medical extract, borneol and the chlorhexidine acetate that bacterium gel is matched by extra fine quality mutually cooperate with, so that it is to vaginitis
Control efficiency is more preferably.
It can be seen that from the comparison of embodiment 1-7 and embodiment 8-9 and comparative example 3-7 when in the clean compact bacteriostatic gel of woman
Chinese medical extract by the glossy privet fruit extract of extra fine quality number, nutgall extractive, smoked plum extractive, safflower extract and
When Honegsukle flower P.E coordinated, more preferably to the control efficiency of vaginitis.
Test example 3
Selected from 170 with vaginal relaxation, itch and peculiar smell female patient, the age is 29-45 years old, be it is married,
Non- menstrual period and period of pregnancy, it is randomly divided into 17 groups, every group of 10 people, the clean compact suppression of the woman that embodiment 1-9 and comparative example 1-7 are provided
Bacterium gel is pushed into patient's intravaginal respectively, once a day, is used continuously 15 days, the 16th group is blank control group, and record is used respectively
Sings and symptoms before and after medicine, the results are shown in Table 3.
Control efficiency table of the clean compact bacteriostatic gel of 3 table of table, 2 woman to private portion's discomfort
Note：Effective standard is clinical symptoms, sign is significantly improved or disappeared, patient satisfaction；Effective standard is symptom
It makes moderate progress or mitigates, patient still has discomfort, it is desirable that continual cure；Invalid standard is symptom without substantially reduced, and patient is discontented
Meaning.
The comparison of embodiment 1-7 and blank control group is as can be seen that the clean compact suppression of woman that embodiment 1-7 is provided from table 3
Bacterium gel reaches 70% or more for the effective percentage of vaginal relaxation, itch and peculiar smell, this illustrates that woman provided by the invention is clean
Compact bacteriostatic gel can effectively facilitate vagina and restore elastic compact, remove odors, sterilizing and itch-relieving, promote female reproductive health.
From table 2, the comparison of embodiment 1-7 and comparative example 1-2 are as can be seen that the clean compact suppression of woman that embodiment 1-7 is provided
Chinese medical extract, borneol and the chlorhexidine acetate that bacterium gel is matched by extra fine quality mutually cooperate with, so as to more effectively
Promote vagina to restore elastic compact, removes odors, sterilizing and itch-relieving, promote female reproductive health.
It can be seen that by the comparison of embodiment 6-7 and embodiment 1-5 by the way that sea is added in the clean compact bacteriostatic gel of woman
Algae peptide and fibroin peptide can be improved the obvious effective rate for vaginal relaxation, peculiar smell and itch, and it is strong to more efficiently facilitate female reproduction
Health.
It can be seen that from the comparison of embodiment 1-7 and embodiment 8-9 and comparative example 3-7 when in the clean compact bacteriostatic gel of woman
Chinese medical extract by the glossy privet fruit extract of extra fine quality number, nutgall extractive, smoked plum extractive, safflower extract and
When Honegsukle flower P.E coordinated, vagina can be more efficiently facilitated and restore elastic compact, remove odors, sterilizing and itch-relieving, promote
Into female reproductive health.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, those skilled in the art should understand that：Its according to
So be possible to modify the technical solutions described in the foregoing embodiments, or to some or all of the technical features into
Row equivalent replacement；And these are modified or replaceed, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of clean compact bacteriostatic gel of woman, which is characterized in that every 100g gel includes Chinese medical extract 1-3g, borneol 0.5-
1.5g, chlorhexidine acetate 0.03-0.09g, surplus are water；Wherein, the Chinese medical extract includes that glossy privet fruit extract, dark plum mention
Take object, safflower extract, nutgall extractive and Honegsukle flower P.E.
2. the clean compact bacteriostatic gel of woman according to claim 1, which is characterized in that every 100g gel includes Chinese medical extract
1.5-2.5g, borneol 0.8-1.2g, chlorhexidine acetate 0.04-0.08g, surplus are water.
3. the clean compact bacteriostatic gel of woman according to claim 1, which is characterized in that every 100g gel includes Chinese medical extract
1.8-2.2g, borneol 0.9-1.1g, chlorhexidine acetate 0.05-0.07g, surplus are water.
4. the clean compact bacteriostatic gel of woman according to claim 1-3, which is characterized in that the traditional Chinese medicine extraction owner
It to include following component according to the mass fraction：20-30 parts of glossy privet fruit extract, 20-30 parts of nutgall extractive, dark plum extracts
10-20 parts of object, 10-20 parts and Honegsukle flower P.E 15-25 parts of safflower extract；
Preferably, the Chinese medical extract mainly includes following component according to the mass fraction：22-28 parts of glossy privet fruit extract,
22-28 parts of nutgall extractive, 12-18 parts of smoked plum extractive, 12-18 parts and Honegsukle flower P.E 18-22 parts of safflower extract.
5. the clean compact bacteriostatic gel of woman according to claim 1-3, which is characterized in that every 100g gel further includes
Fibroin peptide 1.5-2.5g and seaweed peptide 1.5-2.5g；
Preferably, every 100g gel includes fibroin peptide 1.8-2.2g and seaweed peptide 1.8-2.2g.
6. the clean compact bacteriostatic gel of woman according to claim 1-3, which is characterized in that further include auxiliary material；
Preferably, every 100g gel includes auxiliary material 3-10g；
Preferably, the auxiliary material includes at least one of thickener, moisturizer and cosolvent；
Preferably, the thickener is carbomer；
Preferably, the moisturizer is glycerol；
Preferably, the cosolvent is ethyl alcohol.
7. the clean compact bacteriostatic gel of woman according to claim 1-3, which is characterized in that every 100g gel includes sweet
Oily 3-8g, carbomer 0.5-2g and ethyl alcohol 1-3g；
Preferably, every 100g gel includes glycerol 4-6g, carbomer 1-1.5g and ethyl alcohol 1.5-2.5g.
8. the preparation method of the clean compact bacteriostatic gel of woman according to claim 1-7, which is characterized in that including such as
Lower step：
By Chinese medical extract, borneol, chlorhexidine acetate, optional fibroin peptide, optional seaweed peptide and optional auxiliary material point
It is not dissolved in the water, is uniformly mixed, obtains the clean compact bacteriostatic gel of woman.
9. the preparation method of the clean compact bacteriostatic gel of woman according to claim 8, which is characterized in that include the following steps：
(a) Chinese medical extract is dissolved in the water uniformly mixed, obtains the first solution；
(b) chlorhexidine acetate and borneol are dissolved in ethyl alcohol, are uniformly mixed, obtain the second solution；
(c) carbomer is dissolved in the water, emulsification uniformly, obtains third solution；
(d) the first solution, the second solution, third solution and optional fibroin peptide and optional seaweed peptide are uniformly mixed,
Obtain the clean compact bacteriostatic gel of woman.
10. the clean compact bacteriostatic gel of woman according to claim 1-7 is in prevention and treatment gynaecological imflammation and vagina muscles pine
The application for aspect of relaxing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810844128.4A CN108815257A (en) | 2018-07-27 | 2018-07-27 | Clean compact bacteriostatic gel of woman and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810844128.4A CN108815257A (en) | 2018-07-27 | 2018-07-27 | Clean compact bacteriostatic gel of woman and its preparation method and application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108815257A true CN108815257A (en) | 2018-11-16 |
Family
ID=64152024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810844128.4A Pending CN108815257A (en) | 2018-07-27 | 2018-07-27 | Clean compact bacteriostatic gel of woman and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108815257A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109364143A (en) * | 2018-12-05 | 2019-02-22 | 新乡博凯生物技术有限公司 | A kind of gel cream and preparation method thereof |
| CN109771368A (en) * | 2019-02-19 | 2019-05-21 | 湖北伽诺美生物科技有限公司 | A kind of bacteriostatic gel and preparation method thereof |
| CN110787109A (en) * | 2019-12-07 | 2020-02-14 | 路书刚 | Preparation containing peptide for repairing and tightening |
-
2018
- 2018-07-27 CN CN201810844128.4A patent/CN108815257A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109364143A (en) * | 2018-12-05 | 2019-02-22 | 新乡博凯生物技术有限公司 | A kind of gel cream and preparation method thereof |
| CN109771368A (en) * | 2019-02-19 | 2019-05-21 | 湖北伽诺美生物科技有限公司 | A kind of bacteriostatic gel and preparation method thereof |
| CN110787109A (en) * | 2019-12-07 | 2020-02-14 | 路书刚 | Preparation containing peptide for repairing and tightening |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106334067B (en) | Gynecological gel containing silver ion antibacterial agent, preparation method and application | |
| CN108815257A (en) | Clean compact bacteriostatic gel of woman and its preparation method and application | |
| US20150264935A1 (en) | Semi-Fluidic Composition for Lubricating, Moisture Retaining, Disinfecting, Sterilizing and Method Using the Same | |
| US20130108599A1 (en) | Herbal Vaginal Compositions | |
| CN111202822A (en) | Gynecological external antibacterial spray and preparation method thereof | |
| CN107456509B (en) | A kind of external application biological agent and preparation method for vagina prevention, health care and treatment gynaecology genital inflammation | |
| CN109771368A (en) | A kind of bacteriostatic gel and preparation method thereof | |
| CN103405592A (en) | Bacteriostatic water-soluble personal lubricant and preparation method thereof, and condom | |
| CN103405593A (en) | Water soluble human lubricant capable of enhancing libido and preparation method thereof as well as condom | |
| CN110038039A (en) | A kind of bacteriostatic gel and preparation method | |
| CN110585418A (en) | External use disinfection essential oil emulsion for women and production process thereof | |
| CN108567870A (en) | Clean maintenance particle of woman and preparation method thereof, application method and application | |
| CN106074783A (en) | A kind of silver ion bacteriostatic gel and preparation method thereof | |
| CN108671058A (en) | Clean bacteriostasis spray of woman and its preparation method and application | |
| CN105106215B (en) | Treat ointment of acute mammitis of cow and preparation method thereof | |
| CN105999224B (en) | A kind of biomimetic type gynaecologic washing lotion and preparation method thereof | |
| CN108815274A (en) | Clean maintenance bacteriostatic gel of woman and its preparation method and application | |
| CN109758562B (en) | Zedoary composite essential oil and preparation method and application thereof | |
| CN103599437B (en) | One treats colpitic traditional Chinese medicine liquid | |
| CN112602732A (en) | Epidemic prevention traditional Chinese medicine essential oil formula | |
| CN112076252A (en) | Ozone antibacterial gel and preparation method thereof | |
| CN101757119B (en) | Medicine composition for treating vaginitis as well as gel and preparation method thereof | |
| CN1191066C (en) | Externally-used disinfector | |
| CN110840800A (en) | Special postpartum shower gel and preparation method thereof | |
| CN110623919A (en) | Hydrogen-ion-rich acidic maintenance contraceptive gel for gynecology and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: No.1302, No.7, Dongqing street, high tech Industrial Development Zone, Zhengzhou City, Henan Province 450001 Applicant after: Bokai Pharmaceutical Co., Ltd Address before: 450000 No. 5 Acacia Street, hi tech Development Zone, Henan, Zhengzhou Applicant before: Zhengzhou Bokai Medicine &. Health-Care Products Co., Ltd. |
|
| CB02 | Change of applicant information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181116 |
|
| RJ01 | Rejection of invention patent application after publication |