CN106074783A - A kind of silver ion bacteriostatic gel and preparation method thereof - Google Patents

A kind of silver ion bacteriostatic gel and preparation method thereof Download PDF

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Publication number
CN106074783A
CN106074783A CN201610635746.9A CN201610635746A CN106074783A CN 106074783 A CN106074783 A CN 106074783A CN 201610635746 A CN201610635746 A CN 201610635746A CN 106074783 A CN106074783 A CN 106074783A
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parts
silver ion
gel
mentholum
radix sophorae
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刘之伟
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288—Taraxacum (dandelion)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Abstract

The present invention provides a kind of silver ion bacteriostatic gel, including: soluble silver salt, carbomer, propylene glycol, glycerol, Mentholum, Radix Sophorae Flavescentis, Semen Persicae, Herba Taraxaci, its quality proportioning is: soluble silver salt 0.5 0.6 parts, carbomer 78 parts, propylene glycol 50 150 parts, glycerol 50 150 parts, Mentholum 15 20 parts, Radix Sophorae Flavescentis 15 20 parts, 3 15 parts of Semen Persicae, Herba Taraxaci 10 20 parts.Inventive formulation is reasonable, it is simple to make, and has the killing action of strength to pathogenic microorganisms such as antibacterial, fungus, candidiasis, virus, mycoplasma, chlamydia.It is applicable to gynecological inflammation and vaginal infection that all kinds of pathogenic microorganism causes.

Description

A kind of silver ion bacteriostatic gel and preparation method thereof
Technical field
The present invention relates to medicine preparing technical field, be specially a kind of silver ion bacteriostatic gel and preparation method thereof.
Background technology
Women's health is more and more paid close attention to, and various Gynecological health articles for use occurs.General health product is many For oral formulations, its health-care effect is the most inconspicuous, has bigger side effect, and hormone-content is high, be easily caused human body interior point Secrete imbalance；External used medicine is big to skin irritation, easily occur allergic symptom and without bactericidal action problem.
Silver is the most just used for accelerating wound healing, treatment is infected, purify water and preserve beverage, scientific application silver The infection that preparation anti Bacillus pyocyaneu Flugge and staphylococcus aureus cause resulted from for 19th century, until people are just true after 20th century Just finding that silver is a kind of broad-spectrum antiseptic material.Silver ion disinfectant is a kind of nontoxic, tasteless and nonirritant, free of contamination " green is killed Bacterium goods ", it is a kind of non-antibiotic class broad-spectrum antiseptic material.In recent years, silver-ion antibiotic material pref anti-presses down because it is excellent Bacterium performance and safety non-toxic, not producing the characteristic of drug resistance, the application in terms of sterilization and infection increasingly comes into one's own, Demonstrate wide application prospect.
Summary of the invention
Technical problem solved by the invention is to provide a kind of silver ion bacteriostatic gel and preparation method thereof, on solving State the problem in background technology.
Technical problem solved by the invention realizes by the following technical solutions: a kind of silver ion bacteriostatic gel, including: Soluble silver salt, carbomer, propylene glycol, glycerol, Mentholum, Radix Sophorae Flavescentis, Semen Persicae, Herba Taraxaci, its quality proportioning is: soluble silver salt 0.5-0.6 part, carbomer 7-8 part, propylene glycol 50-150 part, glycerol 50-150 part, Mentholum 15-20 part, Radix Sophorae Flavescentis 15-20 part, Semen Persicae 3-15 part, Herba Taraxaci 10-20 part.
Further, its quality proportioning of described silver ion bacteriostatic gel is: soluble silver salt 0.5 part, carbomer 7 parts, third Glycol 50 parts, glycerol 50 parts, Mentholum 15 parts, Radix Sophorae Flavescentis 15 parts, 3 parts of Semen Persicae, Herba Taraxaci 10 parts.
Further, its quality proportioning of described silver ion bacteriostatic gel is: soluble silver salt 0.6 part, carbomer 8 parts, third Glycol 150 parts, glycerol 150 parts, Mentholum 20 parts, Radix Sophorae Flavescentis 20 parts, 15 parts of Semen Persicae, Herba Taraxaci 20 parts.
Further, its quality proportioning of described silver ion bacteriostatic gel is: soluble silver salt 0.5 part, carbomer 7 parts, third Glycol 100 parts, glycerol 100 parts, Mentholum 18 parts, Radix Sophorae Flavescentis 18 parts, 5 parts of Semen Persicae, Herba Taraxaci 15 parts.
Described soluble silver salt is silver nitrate.
The preparation method of a kind of silver ion bacteriostatic gel, comprises the following steps:
(1), weigh silver nitrate 0.5-0.6 part in sterile chamber, add purified water 700-900 part and dissolve；Weigh carbomer 78 Part add dispersion, stir swelling for swelling solution, place 12h and make it the most swelling and stir, standby；
(2) weigh Mentholum 15-20 part, Radix Sophorae Flavescentis 15-20 part, Semen Persicae 3-15 part, Herba Taraxaci 10-20 part grind separation and Extraction respectively Its effective extract, standby；
(3) propylene glycol 50-150 part, glycerol 50-150 part and Mentholum, Radix Sophorae Flavescentis, Semen Persicae, the having of Herba Taraxaci, are weighed and add Effect extract, pH value controls, at 3.5-7, fully to mix, color and luster even, and mixed liquor is oil phase, standby；
(4) it is, under agitation that thread adds in swelling solution by oil phase, fully stirs evenly, make gel, silver ion gynaecological external is resisted Bacterium gel fill in gel device, obtains silver ion antimicrobial gel at disposable vaginal.
Crude drug used in the present invention can be commercially available from common Chinese shop, and its specification meets country's Chinese crude drug standard i.e. Can.
Pharmacology analysis: the present invention combines motherland's dialectical prescription of Chinese medicine marrow and obtains, returning through effect conditioning by medicine Body equilibrium between yin and yang, strengthening the body resistance, improves body constitution, fundamentally, comprehensive plays curative effect for focus, thus reaches thoroughly to control Purpose more.
Soluble silver salt: silver ion be silver atoms lose one or more positively charged sun electronically formed from Son, such as Ag+、Ag2+、Ag3+Deng.Generally existing as an aqueous solution, silver ion has Oxidation, is usually used in daily life Sterilizing etc..Ag+Electronic configuration be 2-8-18-18.Ag is generally aobvious+1 valency in common compounds；Fully replacement cosmetic product And widely used various chemical classes anticorrosive additives in personal-care supplies production, it is substantially reduced anticorrosive additive to skin Injury and harmful effect；Make cosmetics and personal-care supplies content material is more fresh and alive, more purely, can more give full play to make up Product nourish, improve looks, moisten, various effects of whitening and anti-aging be obviously prolonged service life；Promote the healing of skin wound, Increase damaged cell repair function；It is effectively improved moist infiltration effect of cosmetics, the beneficially skin absorption to nutrient substance；More For it is essential that with the addition of cosmetics and the personal-care supplies of silver ion liquid, natural possessed the Initiative Defense merit to antibacterial And and then can directly suppress the antibacterial infringement to skin.Much due to antibacterial itself, skin and the infringement of health mucosal tissue are caused Malaise symptoms also can be readily solved, such as skin allergy, inflammation, indecency body odour, acne vulgaris, the dandruff etc..
Carbomer: for acrylic acid bonding allyl sucrose or the high molecular polymer of tetramethylolmethane allyl ether.By dry product Calculating, (COOH) containing carboxylic acid group should be 56.0%～68.0%.Card ripple is also referred to as carbomer (carbomer), is with tetramethylolmethane etc. Cross-linking, with acrylic acid, the acrylic acid crosslinked resin obtained, be a very important rheology control agent of class, the card ripple after neutralization is excellent Elegant gel-type vehicle, has the important use such as thickening, suspension, and technique is simple, and good stability is widely used in emulsion, cream, gel In.
Propylene glycol: with water, ethanol and multiple immiscible organic solvent.Propylene glycol can be used as the raw material of unsaturated polyester resin. Cosmetics, toothpaste and fancy soap can coordinate with glycerol or sorbitol and be used as wetting agent.
Glycerol is achromatism and clarity syrupy liq, has hygroscopicity, odorless, and taste is micro-sweet, absorb in atmosphere moisture, H2S, HCN and SO2, the aobvious neutrality of liquid, can be the most miscible with water, alcohol, propenyl and ethylene glycol, be slightly soluble in acetone, insoluble in chloroform, Ether.2.6% aqueous solution is isotonic with blood plasma, forbids same oxidant compatibility, low temperature to place solidification.
Mentholum: acrid in the mouth；Cool in nature, perennial fragrance draft, stem is upright, high 30-80cm.The rhizome that tool is crawled, deeply soil Earth can be to 13cm, and matter is crisp, easily snaps off.Sharp four prismatics of stem, multi-branched, four sides without hair or the raw pubescence that somewhat falls, corner and near At joint, hair is more significant；Cure mainly anemopyretic cold；Headache；Conjunctival congestion；Laryngopharynx swelling and pain；Toothache；Skin pruritus.
Radix Sophorae Flavescentis: for the dry root of leguminous plant Radix Sophorae Flavescentis, excavate in spring, season in autumn two, removing root head and little supporting root, cleaning, drying, Or take advantage of fresh slices, it is dried.It is bitter, cold.There are heat clearing and damp drying, parasite killing, the merit of diuresis.For hematodiarrhoea, have blood in stool, jaundice urine retention, red in vain Leukorrhagia, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.Cure mainly: for hematodiarrhoea, just Blood, jaundice urine retention, leucorrhea with red and white discharge, swelling of the vulva pudendal pruritus, eczema, eczema, skin pruritus, scabies leprosy, external treatment trichomonal vaginitis.
Semen Persicae: " Chinese medicine modern study and the application " edited by Zheng Huzhan etc. is recorded: Semen Persicae bitter in the mouth, sweet, property is put down, GUIXIN Liver, large intestine channel, have and improve microcirculation and hemorheology situation." Semen Persicae is raw with when can significantly extend hemorrhage, the blood coagulation of mice Between, there is obvious blood coagulation resisting function." Semen Persicae also has antiinflammatory action, " having notable Anti-Inflammatory Actives in Semen Persicae is protein Class ".
Herba Taraxaci: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, dampness removing is treating stranguria, at whole nation Chinese medicine professorship, high specially Ministry of Public Health programming textbook Described in " pharmacology of Chinese materia medica ": Herba Taraxaci has the effects such as antibacterial, antiviral.
Compared with disclosed technology, there is advantages below in the present invention: inventive formulation rationally, make simple, to antibacterial, true The pathogenic microorganisms such as bacterium, candidiasis, virus, mycoplasma, chlamydia have the killing action of strength.It is applicable to all kinds of pathogenic microorganism The gynecological inflammation caused and vaginal infection.
Detailed description of the invention
It is prone to bright in order to make the technological means of the present invention, creation characteristic, workflow, using method reach purpose with effect White understanding, below in conjunction with the embodiment of the present invention, is clearly and completely described the technical scheme in the embodiment of the present invention, Obviously, described embodiment is only a part of embodiment of the present invention rather than whole embodiments.Based in the present invention Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise, all Belong to the scope of protection of the invention.
Embodiment 1
The preparation method of a kind of silver ion bacteriostatic gel, comprises the following steps:
(1), weigh silver nitrate 0.5g in sterile chamber, add purified water 700g and dissolve；Weigh carbomer 7g and add dispersion, stirring Swelling for swelling solution, place 12h and make it the most swelling and stir.Standby；
(2) weigh Mentholum 15g, Radix Sophorae Flavescentis 15g, Semen Persicae 3g, Herba Taraxaci 10g grind its effective extract of separation and Extraction respectively, standby With；
(3), weigh and add propylene glycol 50g, glycerol 50g and Mentholum, Radix Sophorae Flavescentis, Semen Persicae, the effective extract of Herba Taraxaci, PH Value controls, at 3.5-7, fully to mix, color and luster even, and mixed liquor is oil phase, standby；
(4) it is, under agitation that thread adds in swelling solution by oil phase, fully stirs evenly, make gel, silver ion gynaecological external is resisted Bacterium gel fill in gel device, obtains silver ion antimicrobial gel at disposable vaginal.
During use, removing the protective cap of injector front end, the assistor that will be equipped with gel slowly inserts vagina depths, utilizes Gel is pushed vagina by boosting bar, extracts after keeping 3～5 minutes.
Embodiment 2
The preparation method of a kind of silver ion bacteriostatic gel, comprises the following steps:
(1), weigh silver nitrate 0.6g in sterile chamber, add purified water 900g and dissolve；Weigh carbomer 8g and add dispersion, stirring Swelling for swelling solution, place 12h and make it the most swelling and stir.Standby；
(2) weigh Mentholum 20g, Radix Sophorae Flavescentis 20g, Semen Persicae 15g, Herba Taraxaci 20g grind its effective extract of separation and Extraction respectively, standby With；
(3), weigh and add propylene glycol 150g, glycerol 150g and Mentholum, Radix Sophorae Flavescentis, Semen Persicae, the effective extract of Herba Taraxaci, PH value controls, at 3.5-7, fully to mix, color and luster even, and mixed liquor is oil phase, standby；
(4) it is, under agitation that thread adds in swelling solution by oil phase, fully stirs evenly, make gel, silver ion gynaecological external is resisted Bacterium gel fill in gel device, obtains silver ion antimicrobial gel at disposable vaginal.
During use, removing the protective cap of injector front end, the assistor that will be equipped with gel slowly inserts vagina depths, utilizes Gel is pushed vagina by boosting bar, extracts after keeping 3～5 minutes.
Embodiment 3
The preparation method of a kind of silver ion bacteriostatic gel, comprises the following steps:
(1), weigh silver nitrate 0.5g in sterile chamber, add purified water 700g and dissolve；Weigh carbomer 7g and add dispersion, stirring Swelling for swelling solution, place 12h and make it the most swelling and stir.Standby；
(2) weigh Mentholum 18g, Radix Sophorae Flavescentis 18g, Semen Persicae 5g, Herba Taraxaci 15g grind its effective extract of separation and Extraction respectively, standby With
(3), weigh and add propylene glycol 100g, glycerol 100g and Mentholum, Radix Sophorae Flavescentis, Semen Persicae, the effective extract of Herba Taraxaci, PH value controls, at 3.5-7, fully to mix, color and luster even, and mixed liquor is oil phase, standby；
(4) it is, under agitation that thread adds in swelling solution by oil phase, fully stirs evenly, make gel, silver ion gynaecological external is resisted Bacterium gel fill in gel device, obtains silver ion antimicrobial gel at disposable vaginal.
During use, removing the protective cap of injector front end, the assistor that will be equipped with gel slowly inserts vagina depths, utilizes Gel is pushed vagina by boosting bar, extracts after keeping 3～5 minutes.
The present invention 1. high concentration liquid silver ion raw material, efficient absorption, antibacterial, antiinflammatory two-ways regulation, unique " antibacterial, repair Multiple, lubrication " triple function.2. broad-spectrum antibacterial, includes monilial vaginitis, bacterial vaginosis, infusorian to multiple vaginitis The property highly effective and safe such as vaginitis, vagina mixed infection, has no drug resistance.3. unique hydrogel dosage form, it is not necessary to body water is dissolved, Can be uniformly distributed in intravaginal, recover intravaginal cell regeneration, strengthen the elasticity of vagina, nonirritant, free from extraneous odour, the clearing heat in the pericardium, row Poison, yin nourishing, koro, it is adaptable to vagina maintenance and vaginal disorder of being correlated with.
The pathogenic microorganisms such as antibacterial, fungus, candidiasis, virus, mycoplasma, chlamydia are had strength to kill work by the present invention With.It is applicable to gynecological inflammation and vaginal infection that all kinds of pathogenic microorganism causes, including: mycotic (candidiasis) vaginitis, drips The multiple colpitis such as worm property vaginitis, bacterial vaginitis, gonococcal vaginitis, vagina mixed infection；Interior cloudy pruritus, cervix uteri Erosion, the gynaecopathias such as abnormal flavour, leucorrhoea grow in quantity of smelling as of rotten fish.
The scope of application of the present invention: the aging premonitory symptoms of vagina such as pruritus of vagina, lower body abnormal flavour, leucorrhea abnormal have occurred the most Women；Bacterial infection, trichomonas, colpitis mycotica the most, the aging women starting to accelerate of vagina；3. vagina pine after fertility Relax and significantly affect the women of life quality；4. pathogenic bacteria is caused often to be invaded because of slack vagina, the women that inflammation recurs repeatedly； 5. vaginal dryness, induced life pain, and then affect the women of goodwill as between spouses；6. sexual life enlivens, and vagina needs often to protect Support and the women of protection；7. for prevention slack vagina and the appearance repeatedly of inflammation, it is desirable to carry out the fashion of " vagina maintenance " in advance Women.The sexual life caused the most for various reasons women cold, discordant.
The ultimate principle of the present invention, principal character and advantages of the present invention have more than been shown and described.The technology of the industry Personnel, it should be appreciated that the present invention is not restricted to the described embodiments, simply illustrating this described in above-described embodiment and description The principle of invention, without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, and these become Change and improvement both falls within scope of the claimed invention.The claimed scope of the present invention by appending claims and Its equivalent defines.

Claims (6)

1. a silver ion bacteriostatic gel, it is characterised in that: including: soluble silver salt, carbomer, propylene glycol, glycerol, Herba Menthae Brain, Radix Sophorae Flavescentis, Semen Persicae, Herba Taraxaci, its quality proportioning is: soluble silver salt 0.5-0.6 part, carbomer 7-8 part, propylene glycol 50-150 Part, glycerol 50-150 part, Mentholum 15-20 part, Radix Sophorae Flavescentis 15-20 part, Semen Persicae 3-15 part, Herba Taraxaci 10-20 part.
A kind of silver ion bacteriostatic gel the most according to claim 1, it is characterised in that: described its matter of silver ion bacteriostatic gel Amount proportioning is: soluble silver salt 0.5 part, carbomer 7 parts, propylene glycol 50 parts, glycerol 50 parts, Mentholum 15 parts, Radix Sophorae Flavescentis 15 parts, Fructus Persicae Core 3 parts, Herba Taraxaci 10 parts.
A kind of silver ion bacteriostatic gel the most according to claim 1, it is characterised in that: described its matter of silver ion bacteriostatic gel Amount proportioning be: soluble silver salt 0.6 part, carbomer 8 parts, propylene glycol 150 parts, glycerol 150 parts, Mentholum 20 parts, Radix Sophorae Flavescentis 20 parts, 15 parts of Semen Persicae, Herba Taraxaci 20 parts.
A kind of silver ion bacteriostatic gel the most according to claim 1, it is characterised in that: described its matter of silver ion bacteriostatic gel Amount proportioning be: soluble silver salt 0.5 part, carbomer 7 parts, propylene glycol 100 parts, glycerol 100 parts, Mentholum 18 parts, Radix Sophorae Flavescentis 18 parts, 5 parts of Semen Persicae, Herba Taraxaci 15 parts.
5. according to a kind of silver ion bacteriostatic gel described in claim 1-4 any one, it is characterised in that: described silver soluble Salt is silver nitrate.
6. a preparation method for silver ion bacteriostatic gel, comprises the following steps:
(1), weigh silver nitrate 0.5-0.6 part in sterile chamber, add purified water 700-900 part and dissolve；Weigh carbomer 7-8 part Add dispersion, stir swelling for swelling solution, place 12h and make it the most swelling and stir, standby；
(2) weigh Mentholum 15-20 part, Radix Sophorae Flavescentis 15-20 part, Semen Persicae 3-15 part, Herba Taraxaci 10-20 part grind separation and Extraction respectively Its effective extract, standby；
(3) propylene glycol 50-150 part, glycerol 50-150 part and Mentholum, Radix Sophorae Flavescentis, Semen Persicae, the having of Herba Taraxaci, are weighed and add Effect extract, pH value controls, at 3.5-7, fully to mix, color and luster even, and mixed liquor is oil phase, standby；
(4) it is, under agitation that thread adds in swelling solution by oil phase, fully stirs evenly, make gel, silver ion gynaecological external is resisted Bacterium gel fill in gel device, obtains silver ion antimicrobial gel at disposable vaginal.
CN201610635746.9A 2016-08-05 2016-08-05 A kind of silver ion bacteriostatic gel and preparation method thereof Pending CN106074783A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112190541A (en) * 2020-09-27 2021-01-08 安婕妤化妆品科技股份有限公司 Privacy care gel product
CN113244287A (en) * 2021-05-10 2021-08-13 广州天恩药业科技有限公司 Traditional Chinese medicine preparation formula for treating female vaginitis
CN113813442A (en) * 2021-09-29 2021-12-21 王旺盛 Artemisia desertorum gum antibacterial gel formula

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112190541A (en) * 2020-09-27 2021-01-08 安婕妤化妆品科技股份有限公司 Privacy care gel product
CN113244287A (en) * 2021-05-10 2021-08-13 广州天恩药业科技有限公司 Traditional Chinese medicine preparation formula for treating female vaginitis
CN113813442A (en) * 2021-09-29 2021-12-21 王旺盛 Artemisia desertorum gum antibacterial gel formula

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