CN108671058A - Clean bacteriostasis spray of woman and its preparation method and application - Google Patents
Clean bacteriostasis spray of woman and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/58—Meliaceae (Chinaberry or Mahogany family), e.g. Azadirachta (neem)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention provides clean bacteriostasis spray of a kind of woman and its preparation method and application, it is related to Amino-Cerv technical field, in the clean bacteriostasis spray of woman, include 0.2 1g of Chinese medical extract per 100g sprays, 0.05 0.3g of 0.2 1g of brown alga oligose, 0.5 2g of borneol and chlorhexidine acetate, surplus is water；The Chinese medical extract is mainly by centella, frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach extract, improving existing gynaecology's antibacterial medicines is made by acidic disinfectant mostly, long-time service can cause to damage to vagina skin and mucous membrane, the technical issues of even causing hyperblastosis, the clean bacteriostasis spray of woman provided by the invention can not only effectively inhibit staphylococcus aureus, the growth and breeding of Candida albicans and Escherichia coli, and mucous membrane can be repaired, prevent microorganism from infecting again, vagina normal flora and acid-base balance can also be maintained simultaneously, promote female reproductive health.
Description
Technical field
The present invention relates to Amino-Cerv technical fields, more particularly, to clean bacteriostasis spray of a kind of woman and preparation method thereof and answer
With.
Background technology
Due to the particularity of female sex organ, gynaecological imflammation has become common, the frequently-occurring disease of adult female, clinical table
Existing varied, the cause of disease is complicated and is often accompanied by a variety of Complicated with Severe diseases, has a significant impact to the live and work of women.
Antibacterial medicines type currently used for gynaecology is various, but most of antibacterial medicines are with acidic disinfectant by one
Determine the product of concentration requirement making, such drug, which is used for a long time, to be caused to damage to vagina skin and mucous membrane, or even causes tissue
Hyperplasia.
In view of this, special propose the present invention.
Invention content
One of the objects of the present invention is to provide a kind of clean bacteriostasis sprays of woman, most to improve existing gynaecology's antibacterial medicines
It is to be made by acidic disinfectant, long-time service can cause to damage to vagina skin and mucous membrane, or even cause hyperblastosis
Technical problem.
The clean bacteriostasis spray of woman provided by the invention includes Chinese medical extract 0.2-1g, brown alga oligose 0.2- per 100g sprays
1g, borneol 0.5-2g and chlorhexidine acetate 0.05-0.3g, surplus are water；The Chinese medical extract is mainly by centella, cnidium monnieri
Son, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach extract.
Further, include Chinese medical extract 0.3-0.8g, brown alga oligose 0.3-0.8g, borneol 0.5- per 100g sprays
1.5g and chlorhexidine acetate 0.1-0.2g, surplus are water.
Further, include Chinese medical extract 0.4-0.6g, brown alga oligose 0.4-0.6g, borneol 0.8- per 100g sprays
1.2g and chlorhexidine acetate 0.12-0.18g, surplus are water.
Further, the Chinese medical extract is mainly extracted by the raw material of following mass parts：5-15 parts of centella, snake
10-20 parts of 10-20 parts of machine tool, 10-20 parts of Cortex Phellodendri, 10-20 parts of kuh-seng, 10-20 parts of radix scutellariae, 10-20 parts of rheum officinale and azedarach；
Preferably, the Chinese medical extract is mainly extracted by the raw material of following mass parts：8-12 parts of centella, cnidium monnieri
It is 12-18 parts sub-, 12-18 parts of Cortex Phellodendri, 12-18 parts of kuh-seng, 12-18 parts of radix scutellariae, 12-18 parts of 12-18 parts of rheum officinale and azedarach.
Further, the clean bacteriostasis spray of the woman further includes auxiliary material；
Preferably, include auxiliary material 20-40g per 100g sprays；
It is further preferred that including auxiliary material 25-35g per 100g sprays；
Preferably, the auxiliary material includes at least one in surfactant, thickener, emulsifier, moisturizer and preservative
Kind；
It is further preferred that the auxiliary material includes surfactant, thickener, emulsifier, moisturizer and preservative.
Further, include surfactant 10-20g, thickener 1-5g, emulsifier 1-5g, preservative per 100g sprays
0.1-0.5g and moisturizer 5-15g；
Preferably, further include surfactant 12-18g, thickener 1-3g, emulsifier 1-3g, preservative per 100g sprays
0.2-0.4g and moisturizer 8-12g.
Further, the surfactant is selected from lauryl hydroxyl sulfo betaine, cocounut oil both sexes guanidine-acetic acid sodium or the moon
At least one of laureth sulfosuccinate disodium；
Preferably, the surfactant includes lauryl hydroxyl sulfo betaine, cocounut oil both sexes guanidine-acetic acid sodium and bay
Alcohol polyethers sulfosuccinate disodium；
Preferably, the thickener is sodium alginate；
Preferably, the emulsifier is Tween-80；
Preferably, the moisturizer is glycerine；
Preferably, the preservative is sodium benzoate.
The second object of the present invention is to provide a kind of preparation method of the clean bacteriostasis spray of woman, include the following steps：Will in
Medicament extract, brown alga oligose, borneol, chlorhexidine acetate, optional auxiliary material and water are uniformly mixed, and obtain the clean bacteriostasis spray of woman.
Further, the preparation method of the Chinese medical extract includes the following steps：By centella, frutus cnidii, Cortex Phellodendri, hardship
Ginseng, radix scutellariae, rheum officinale and azedarach add flooding, filter to take filtered fluid, concentrate, dry, obtain Chinese medical extract.
The third object of the present invention is to provide application of the clean bacteriostasis spray of woman in terms of preventing gynaecological imflammation；
Preferably, the gynaecological imflammation includes vaginitis, cervicitis and pelvic infecton.
The clean bacteriostasis spray of woman provided by the invention is mutual by Chinese medical extract, brown alga oligose, borneol and chlorhexidine acetate
Collaboration, can not only effectively inhibit the growth and breeding of staphylococcus aureus, Candida albicans and Escherichia coli, and can
Mucous membrane is repaired, prevents microorganism from infecting again, while vagina normal flora and acid-base balance can also be maintained, promotes female reproduction strong
Health.
In addition, the clean bacteriostasis spray of woman provided by the invention does not stimulate mildly, have no toxic side effect, long-time service will not give people
Body health impacts.
The preparation method of the clean bacteriostasis spray of woman after present invention offer is simple for process, easy to operate, can be suitable for industry
Change big production, improves production efficiency.
Specific implementation mode
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
According to an aspect of the present invention, the present invention provides a kind of clean bacteriostasis sprays of woman, include Chinese medicine per 100g sprays
Extract 0.2-1g, brown alga oligose 0.2-1g, borneol 0.5-2g and chlorhexidine acetate 0.05-0.3g, surplus are water；The Chinese medicine
Extract is mainly extracted by centella, frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach.
In the clean bacteriostasis spray of woman provided by the invention, per 100g sprays in, Chinese medical extract it is typical but non-limiting
Quality as 0.2g, 0.25g, 0.3g, 0.35g, 0.4g, 0.45g, 0.5g, 0.55g, 0.6g, 0.65g, 0.7g, 0.75g,
0.8g, 0.85g, 0.9g, 0.95g or 1g.
Chinese medical extract is mutually cooperateed with by centella, frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach, can
Effective anti-inflammatory anti-itch, antibacterial bacteriostatic, while can also have promoting blood circulation and stopping pain, it dissipates stasis of blood life newly, promotes female reproductive system health.
In the clean bacteriostasis spray of woman provided by the invention, per 100g sprays in, brown alga oligose it is typical but non-limiting
Quality as 0.2g, 0.25g, 0.3g, 0.35g, 0.4g, 0.45g, 0.5g, 0.55g, 0.6g, 0.65g, 0.7g, 0.75g,
0.8g, 0.85g, 0.9g, 0.95g or 1g.
Brown alga oligose is the oligomer of algin, is a kind of functional oligosaccharide, brown alga oligose is by β-D mannuronic acids and its
C-5 epimer α-L guluronic acids are formed by 1-4 glucosides key connections.Brown alga oligose molecular weight is low, not only water-soluble
By force, stability is high, and has many bioactivity, can stimulate biochemistry, maturation and the breeding of various immunocompetent cells, make machine
The immune system of body is restored and reinforces, and a variety of physiological activity can be played by immunoregulation effect.
In the clean bacteriostasis spray of woman provided by the invention, in every 100g sprays, the typical but non-limiting quality of borneol
Such as it is 0.5g, 0.6g, 0.7g, 0.8g, 0.9g, 1g, 1.1g, 1.2g, 1.3g, 1.4g, 1.5g, 1.6g, 1.7g, 1.8g, 1.9g
Or 2g.
Borneol is the crystallization obtained from the resin and volatile oil of kapur, enters the heart, lung channel, has and leads to all keys, dissipates stagnated fire,
Screen improving eyesight is gone, the effect of swelling and pain relieving.
In the clean bacteriostasis spray of woman provided by the invention, per 100g sprays in, chlorhexidine acetate it is typical but non-limiting
Quality as 0.05g, 0.06g, 0.07g, 0.08g, 0.09g, 0.1g, 0.12g, 0.15g, 0.18g, 0.2g, 0.22g,
0.25g, 0.28g or 0.3g.
Chlorhexidine acetate is the efficient spectrum fungicide of biguanides, makes cellular content by changing bacterial cytoplasm membrane permeability
It leaks out and plays bactericidal effect, stronger killing effect is all had to most of Gram-positive bacillus and negative bacillus, to green
Purulence bacillus and fungi also have good killing effect.
The clean bacteriostasis spray of woman provided by the invention is mutual by Chinese medical extract, brown alga oligose, borneol and chlorhexidine acetate
Collaboration, can not only effectively inhibit the growth and breeding of staphylococcus aureus, Candida albicans and Escherichia coli, and can
Mucous membrane is repaired, prevents microorganism from infecting again, while vagina normal flora and acid-base balance can also be maintained, promotes female reproduction strong
Health.
In addition, the clean bacteriostasis spray of woman provided by the invention does not stimulate mildly, have no toxic side effect, long-time service will not give people
Body health impacts.
In the preferred embodiment of the present invention, Chinese medical extract mainly by the raw material of following mass parts extract and
At：5-15 parts of centella, 10-20 parts of frutus cnidii, 10-20 parts of Cortex Phellodendri, 10-20 parts of kuh-seng, 10-20 parts of radix scutellariae, 10-20 parts of rheum officinale
With 10-20 parts of azedarach；
In the preferred embodiment of the present invention, in the raw material for preparing Chinese medical extract, the typical but non-limit of centella
The mass fraction of property processed as 5,5.5,6,6.5,7,7.5,8,8.5,9,9.5,10,10.5,11,11.5,12,12.5,13,
13.5,114,14.5 or 15 parts.
Centella is also known as pennyroyal mint, has effects that clearing heat and promoting diuresis and subdhing swelling and detoxicating, can inhibit proliferation of fibrous tissue, promotees
Increase into skin, and skin ulcer can be inhibited.
In the preferred embodiment of the present invention, in the raw material for preparing Chinese medical extract, the typical but non-limit of frutus cnidii
The mass fraction of property processed is as being 20,21,22,23,24,25,26,27,28,29 or 30 parts.
Frutus cnidii is the dry mature fruit of samphire cnidium monnieri, and warm-natured, bitter has eliminating dampness, wind-dispelling, desinsection and temperature
The effect of kidney and enhancing body.
The present invention the preferred embodiment in, in the raw material for preparing Chinese medical extract, Cortex Phellodendri it is typical but unrestricted
Property mass fraction as be 10,11,12,13,14,15,16,17,18,19 or 20 parts.
Cortex Phellodendri bitter, cold in nature, clearing heat and detoxicating, purging intense heat eliminating dampness can prevent skin sore and skin eczema.
The present invention the preferred embodiment in, in the raw material for preparing Chinese medical extract, kuh-seng it is typical but unrestricted
Property mass fraction as be 10,11,12,13,14,15,16,17,18,19 or 20 parts.
Kuh-seng, draft or undershrub have effects that clearing heat and promoting diuresis, antibacterial anti-inflammatory and stomach invigorating expelling parasite.
The present invention the preferred embodiment in, in the raw material for preparing Chinese medical extract, radix scutellariae it is typical but unrestricted
Property mass fraction as be 10,11,12,13,14,15,16,17,18,19 or 20 parts.
The root of radix scutellariae is used as medicine, and bitter is cold in nature, there is the effect of heat-clearing and damp-drying drug, purging intense heat and detonicating and arresting bleeding and miscarriage prevention.
The present invention the preferred embodiment in, in the raw material for preparing Chinese medical extract, rheum officinale it is typical but unrestricted
Property mass fraction as be 10,11,12,13,14,15,16,17,18,19 or 20 parts.
Rheum officinale, which has, attacks stagnant, clearing away damp-heat, purging intense heat, cool blood, dissolving stasis and removing toxic substances and other effects.
In the preferred embodiment of the present invention, in the raw material for preparing Chinese medical extract, the typical but non-limit of azedarach
The mass fraction of property processed is as being 10,11,12,13,14,15,16,17,18,19 or 20 parts.
Azedarach also known as bitter Siberian cocklebur, have effects that heat-clearing, eliminating dampness and desinsection.
In the preferred embodiment of the present invention, the clean bacteriostasis spray of woman further includes auxiliary material.
Auxiliary material is added so that in the clean bacteriostasis spray of manufactured woman each raw material mix more uniformly, and it is made to be more easy to
It is used in as spray.
In the preferred embodiment of the present invention, include auxiliary material 20-40g per 100g sprays.
In the preferred embodiment of the present invention, the typical but non-limiting quality of contained auxiliary material in every 100g sprays
Such as it is 20g, 22g, 25g, 28g, 30g, 32g, 35g, 38g or 40g.
In the preferred embodiment of the present invention, auxiliary material includes surfactant, thickener, emulsifier, moisturizer
Preferably not only included surfactant, thickener and emulsifier one or more of with preservative, but also including moisturizer and anti-
Rotten agent.
In the preferred embodiment of the present invention, include surfactant 10-20g, thickener 1- per 100g sprays
5g, emulsifier 1-5g, preservative 0.1-0.5g and moisturizer 5-15g.
In the preferred embodiment of the present invention, per 100g sprays in, surfactant it is typical but non-limiting
Quality is as being 10g, 11g, 12g, 13g, 14g, 15g, 16g, 17g, 18g, 19g or 20g；Thickener it is typical but non-limiting
Quality as 1g, 1.2g, 1.5g, 1.8g, 2g, 2.2g, 2.5g, 2.8g, 3g, 3.2g, 3.5g, 3.8g, 4g, 4.2g, 4.5g,
4.8g or 5g；The typical but non-limiting quality of emulsifier as 1g, 1.2g, 1.5g, 1.8g, 2g, 2.2g, 2.5g, 2.8g,
3g, 3.2g, 3.5g, 3.8g, 4g, 4.2g, 4.5g, 4.8g or 5g；The typical but non-limiting quality of preservative as 0.1g,
0.15g, 0.2g, 0.25g, 0.3g, 0.35g, 0.4g, 0.45g or 0.5g；The typical but non-limiting quality of moisturizer is such as
5g, 5.5g, 6g, 6.5g, 7g, 7.5g, 8g, 8.5g, 9g, 9.5g, 10g, 10.5g, 11g, 12g, 13g, 14g or 15g.
In present invention further optimization embodiment, surfactant is selected from lauryl hydroxyl sulfo betaine, coconut palm
One or more of oily both sexes guanidine-acetic acid sodium or laureth sulfosuccinate disodium, more preferably by sulfobetaines,
Cocounut oil both sexes guanidine-acetic acid sodium or laureth sulfosuccinate disodium three's coordinated form, so that each raw material component
What is mixed is more uniform.
In the preferred embodiment of the present invention, thickener is sodium alginate.
Sodium alginate is a kind of natural polysaccharide, and stability, dissolubility, viscosity and safety are all good.
In the preferred embodiment of the present invention, emulsifier is Tween-80.
Tween-80 is a kind of nonionic surface active agent and emulsifier, passes through ethoxylation by sorbitan and oleic acid
It is made, it is safe and non-toxic, do not interfere with health.
In the preferred embodiment of the present invention, preservative is sodium benzoate.
Sodium benzoate can effectively inhibit microbial reproduction and life by preventing the rotten effect turned sour and extended the shelf life
It is long.
According to the second aspect of the invention, the present invention provides a kind of preparation methods of the clean bacteriostasis spray of woman, including such as
Lower step：Chinese medical extract, brown alga oligose, borneol, chlorhexidine acetate, optional auxiliary material and water are uniformly mixed, woman is obtained
Clean bacteriostasis spray.
The preparation method of the clean bacteriostasis spray of woman after present invention offer is simple for process, easy to operate, can be suitable for industry
Change big production, improves production efficiency.
In the preferred embodiment of the present invention, the preparation method of Chinese medical extract includes the following steps：By accumulated snow
Grass, frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach add flooding, filter to take filtered fluid, concentrate, dry, obtain Chinese medicine
Extract.
By adding water to carry out adding flooding centella, frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach, so that
The active ingredient obtained in raw material components can be safely and efficiently leached out, and play drug effect.
According to the third aspect of the present invention, the answering in terms of preventing gynaecological imflammation the present invention provides the clean bacteriostasis spray of woman
With.
In the present invention, gynaecological imflammation includes but not limited to vaginitis, cervicitis and pelvic infecton.
Technical solution provided by the invention is further described with reference to embodiment and comparative example.
Embodiment 1
A kind of clean bacteriostasis spray of woman is present embodiments provided, includes Chinese medical extract 0.2g, brown alga oligose per 100g sprays
1g, borneol 0.5g, chlorhexidine acetate 0.3g, lauryl hydroxyl sulfo betaine 5g, laureth sulfosuccinate disodium
5g, sodium cocoamphoacetate 5g, Tween 80 2g and sodium benzoate 0.25g, surplus are water, wherein Chinese medical extract be by
The following raw material extraction according to the mass fraction is prepared：15 parts of centella, 10 parts of frutus cnidii, 20 parts of Cortex Phellodendri, 10 parts of kuh-seng are yellow
15 parts of 20 parts of a kind of reed mentioned in ancient books, 10 parts of rheum officinale and azedarach.
Embodiment 2
A kind of clean bacteriostasis spray of woman is present embodiments provided, includes Chinese medical extract 1g, brown alga oligose per 100g sprays
0.2g, borneol 0.5g, chlorhexidine acetate 0.05g, lauryl hydroxyl sulfo betaine 5g, laureth sulfosuccinate two
Sodium 5g, sodium cocoamphoacetate 5g, Tween 80 2g and sodium benzoate 0.25g, surplus are water, and wherein Chinese medical extract is
It is prepared by the following raw material extraction according to the mass fraction：15 parts of centella, 20 parts of frutus cnidii, 10 parts of Cortex Phellodendri, 20 parts of kuh-seng,
10 parts of 10 parts of radix scutellariae, 15 parts of rheum officinale and azedarach.
Embodiment 3
A kind of clean bacteriostasis spray of woman is present embodiments provided, includes Chinese medical extract 0.3g, brown alga oligose per 100g sprays
0.8g, borneol 0.5g, chlorhexidine acetate 0.2g, lauryl hydroxyl sulfo betaine 5g, laureth sulfosuccinate two
Sodium 5g, sodium cocoamphoacetate 5g, Tween 80 2g and sodium benzoate 0.25g, surplus are water, and wherein Chinese medical extract is
It is prepared by the following raw material extraction according to the mass fraction：8 parts of centella, 18 parts of frutus cnidii, 12 parts of Cortex Phellodendri, 18 parts of kuh-seng,
12 parts of 14 parts of radix scutellariae, 18 parts of rheum officinale and azedarach.
Embodiment 4
A kind of clean bacteriostasis spray of woman is present embodiments provided, includes Chinese medical extract 0.8g, brown alga oligose per 100g sprays
0.3g, borneol 1.5g, chlorhexidine acetate 0.1g, lauryl hydroxyl sulfo betaine 5g, laureth sulfosuccinate two
Sodium 5g, sodium cocoamphoacetate 5g, Tween 80 2g and sodium benzoate 0.25g, surplus are water, and wherein Chinese medical extract is
It is prepared by the following raw material extraction according to the mass fraction：10 parts of centella, 12 parts of frutus cnidii, 18 parts of Cortex Phellodendri, 12 parts of kuh-seng,
18 parts of 18 parts of radix scutellariae, 12 parts of rheum officinale and azedarach.
Embodiment 5
A kind of clean bacteriostasis spray of woman is present embodiments provided, includes Chinese medical extract 0.4g, brown alga oligose per 100g sprays
0.6g, borneol 0.8g, chlorhexidine acetate 0.18g, lauryl hydroxyl sulfo betaine 5g, laureth sulfosuccinate two
Sodium 5g, sodium cocoamphoacetate 5g, Tween 80 2g and sodium benzoate 0.25g, surplus are water, and wherein Chinese medical extract is
It is prepared by the following raw material extraction according to the mass fraction：10 parts of centella, 15 parts of frutus cnidii, 15 parts of Cortex Phellodendri, 15 parts of kuh-seng,
15 parts of 15 parts of radix scutellariae, 15 parts of rheum officinale and azedarach.
Embodiment 6
A kind of clean bacteriostasis spray of woman is present embodiments provided, includes Chinese medical extract 0.6g, brown alga oligose per 100g sprays
0.4g, borneol 1.2g, chlorhexidine acetate 0.12g, lauryl hydroxyl sulfo betaine 5g, laureth sulfosuccinate two
Sodium 5g, sodium cocoamphoacetate 5g, Tween 80 2g and sodium benzoate 0.25g, surplus are water, and wherein Chinese medical extract is
It is prepared by the following raw material extraction according to the mass fraction：10 parts of centella, 15 parts of frutus cnidii, 15 parts of Cortex Phellodendri, 15 parts of kuh-seng,
15 parts of 15 parts of radix scutellariae, 15 parts of rheum officinale and azedarach.
Embodiment 7
A kind of clean bacteriostasis spray of woman is present embodiments provided, includes Chinese medical extract 0.5g, brown alga oligose per 100g sprays
0.5g, borneol 1g, chlorhexidine acetate 0.15g, lauryl hydroxyl sulfo betaine 5g, laureth sulfosuccinate disodium
5g, sodium cocoamphoacetate 5g, Tween 80 2g and sodium benzoate 0.25g, surplus are water, wherein Chinese medical extract be by
The following raw material extraction according to the mass fraction is prepared：10 parts of centella, 15 parts of frutus cnidii, 15 parts of Cortex Phellodendri, 15 parts of kuh-seng are yellow
15 parts of 15 parts of a kind of reed mentioned in ancient books, 15 parts of rheum officinale and azedarach.
Embodiment 8
Present embodiments provide a kind of preparation method of the clean bacteriostasis spray of woman, the clean bacteriostasis spray of woman that embodiment 1-7 is provided
It is prepared in the method：Specifically comprise the following steps：
(1) centella, frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach are added into flooding, filter to take filtered fluid,
Concentration, it is dry, obtain Chinese medical extract.
(2) by Chinese medical extract, brown alga oligose, borneol, chlorhexidine acetate, lauryl hydroxyl sulfo betaine, laruyl alcohol
Polyethers sulfosuccinate disodium, sodium cocoamphoacetate, Tween 80 and sodium benzoate are uniformly mixed, and obtain the clean suppression of woman
Bacterium spray.
Comparative example 1
This comparative example provides a kind of clean bacteriostasis spray of woman, the difference is that, brown alga widow is not added with embodiment 7
Sugar.
Comparative example 2
This comparative example provides a kind of clean bacteriostasis spray of woman, the difference is that, borneol is not added with embodiment 7.
Comparative example 3
This comparative example provides a kind of clean bacteriostasis spray of woman, the difference is that, acetic acid chlorine is not added with embodiment 7
Oneself is fixed.
Comparative example 4
This comparative example provides a kind of clean bacteriostasis spray of woman, with embodiment 7 the difference is that, Chinese medical extract
Centella is not added in raw material.
Comparative example 5
This comparative example provides a kind of clean bacteriostasis spray of woman, with embodiment 7 the difference is that, Chinese medical extract
Frutus cnidii is not added in raw material.
Comparative example 6
This comparative example provides a kind of clean bacteriostasis spray of woman, with embodiment 7 the difference is that, Chinese medical extract
Radix scutellariae is not added in raw material.
Comparative example 7
This comparative example provides a kind of clean bacteriostasis spray of woman, with embodiment 7 the difference is that, Chinese medical extract
Rheum officinale is not added in raw material.
Comparative example 8
This comparative example provides a kind of clean bacteriostasis spray of woman, with embodiment 7 the difference is that, Chinese medical extract
Azedarach is not added in raw material.
Comparative example 9
This comparative example provides a kind of clean bacteriostasis spray of woman, the difference is that, Chinese medical extract is with embodiment 7
It is prepared by the following raw material extraction according to the mass fraction：25 parts of centella, 30 parts of frutus cnidii, 5 parts of Cortex Phellodendri, 5 parts of kuh-seng are yellow
5 parts of 5 parts of a kind of reed mentioned in ancient books, 25 parts of rheum officinale and azedarach.
The preparation method for the clean bacteriostasis spray of woman that comparative example 1-9 is provided is with embodiment 7, and details are not described herein.
Test example 1
The clean bacteriostasis spray of woman that embodiment 1-7 and comparative example 1-9 are provided is placed in 37 DEG C of insulating boxs 3 months, phase is kept
To humidity 75%, bacteriostasis property test is carried out, as a result shown in table 1.
The clean bacteriostasis spray bacteriostasis property tables of data of 1 woman of table
The comparison of embodiment 1-7 and blank control group can be seen that the clean bacteriostasis spray energy of woman provided by the invention from table 1
Enough growths for effectively inhibiting Escherichia coli, staphylococcus aureus and Candida albicans, prevent microorganism from infecting again, maintain vagina
Normal flora balances, and promotes female reproductive health.
From the comparison of embodiment 1-7 and comparative example 1-3 as can be seen that the clean bacteriostasis spray of woman that embodiment 1-7 is provided passes through
Chinese medical extract, brown alga oligose, borneol and the chlorhexidine acetate of extra fine quality proportioning mutually cooperate with, to Escherichia coli, golden yellow
The inhibition of staphylococcus and Candida albicans is more preferably.
From the comparison of embodiment 1-7 and comparative example 4-9 as can be seen that when the Chinese medical extract in gynaecology's maintenance bacteriostatic gel
When being prepared by the extraction of the centella of extra fine quality number, frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach, resist
Bacterium fungistatic effect is more preferably.
Test example 2
The female patient for suffering from gynecological disease selected from 850, the age is 29-45 Sui, is married, non-menstrual period and bosom
In the pregnancy period, it is randomly divided into 17 groups, every group of 50 people, nonspecific vaginitis (III, IV degree of vagina cleanness degree) 20 in every group is trichomonas
Vaginitis 15, colpomycosis 15 spray the clean bacteriostasis spray of woman that embodiment 1-7 and comparative example 1-9 are provided respectively
In the pelvic cavity trigonum of 1-16 group patients, one day every time, continuous spray 15 days, the 17th group was blank control group, and record is used respectively
Symptom before and after medicine, sign, laboratory examination leukorrhea routine inspection result.The results are shown in Table 2 for prevention.
Control effect table of the clean bacteriostasis spray of 2 woman of table to vaginitis
Note：The standard of healing is clinical symptoms, sign disappearance, and nonspecific vaginitis vaginal fluid checks that cleannes exist
I-II degree, leukorrhea routine inspection pathogen are turned out cloudy；The standard of improvement is clinical symptoms, sign partial disappearance, non-specific vagina
Scorching vaginal fluid checks cleannes part in I-II degree, and leukorrhea routine inspection pathogen is turned out cloudy；Invalid standard be it is clinical,
Sign is without change, and nonspecific vaginitis vaginal fluid checks cleannes in III-IV degree, and leukorrhea routine inspection pathogen is still
For the positive.
The comparison of embodiment 1-7 and blank control group is as can be seen that the clean antibacterial spray of woman that embodiment 1-7 is provided from table 2
The effective percentage of agent reaches 90% or more, and cure rate also reaches 70% or more, this illustrates the clean bacteriostasis spray of woman provided by the invention
Vaginal pathogenic effectively can be killed and remove, bacterio static itching-relieving prevents microorganism from infecting again, maintains vagina normal flora balance,
Restore normal physiological context.
From table 2, the comparison of embodiment 1-7 and comparative example 1-3 is as can be seen that the clean antibacterial spray of woman that embodiment 1-7 is provided
Chinese medical extract, brown alga oligose, borneol and the chlorhexidine acetate that agent is matched by extra fine quality mutually cooperate with so that it is to vagina
Scorching control effect more preferably, cure rate higher.
From the comparison of embodiment 1-7 and comparative example 4-9 as can be seen that when the Chinese medical extract in the clean bacteriostasis spray of woman is by spy
When determining the centella of mass fraction, frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach extraction and being prepared so that its is right
The control effect of vaginitis more preferably, cure rate higher.
Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent
Present invention has been described in detail with reference to the aforementioned embodiments for pipe, it will be understood by those of ordinary skill in the art that：Its according to
So can with technical scheme described in the above embodiments is modified, either to which part or all technical features into
Row equivalent replacement；And these modifications or replacements, various embodiments of the present invention technology that it does not separate the essence of the corresponding technical solution
The range of scheme.
Claims (10)
1. a kind of clean bacteriostasis spray of woman, which is characterized in that every 100g sprays include Chinese medical extract 0.2-1g, brown alga oligose 0.2-
1g, borneol 0.5-2g and chlorhexidine acetate 0.05-0.3g, surplus are water；The Chinese medical extract is mainly by centella, cnidium monnieri
Son, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach extract.
2. the clean bacteriostasis spray of woman according to claim 1, which is characterized in that every 100g sprays include Chinese medical extract 0.3-
0.8g, brown alga oligose 0.3-0.8g, borneol 0.5-1.5g and chlorhexidine acetate 0.1-0.2g, surplus are water.
3. the clean bacteriostasis spray of woman according to claim 1, which is characterized in that every 100g sprays include Chinese medical extract 0.4-
0.6g, brown alga oligose 0.4-0.6g, borneol 0.8-1.2g and chlorhexidine acetate 0.12-0.18g, surplus are water.
4. according to the clean bacteriostasis spray of claim 1-3 any one of them woman, which is characterized in that the Chinese medical extract mainly by
The raw material of following mass parts extracts：5-15 parts of centella, 10-20 parts of frutus cnidii, 10-20 parts of Cortex Phellodendri, 10-20 parts of kuh-seng,
10-20 parts of 10-20 parts of radix scutellariae, 10-20 parts of rheum officinale and azedarach；
Preferably, the Chinese medical extract is mainly extracted by the raw material of following mass parts：8-12 parts of centella, frutus cnidii
12-18 parts, 12-18 parts of Cortex Phellodendri, 12-18 parts of kuh-seng, 12-18 parts of radix scutellariae, 12-18 parts of 12-18 parts of rheum officinale and azedarach.
5. according to the clean bacteriostasis spray of claim 1-3 any one of them woman, which is characterized in that further include auxiliary material；
Preferably, include auxiliary material 20-40g per 100g sprays；
It is further preferred that including auxiliary material 25-35g per 100g sprays；
Preferably, the auxiliary material includes surfactant, thickener, emulsifier, moisturizer and at least one of the preservatives；
It is further preferred that the auxiliary material includes surfactant, thickener, emulsifier, moisturizer and preservative.
6. the clean bacteriostasis spray of woman according to claim 5, which is characterized in that every 100g sprays include surfactant 10-
20g, thickener 1-5g, emulsifier 1-5g, preservative 0.1-0.5g and moisturizer 5-15g；
Preferably, further include surfactant 12-18g, thickener 1-3g, emulsifier 1-3g, preservative 0.2- per 100g sprays
0.4g and moisturizer 8-12g.
7. the clean bacteriostasis spray of woman according to claim 5, which is characterized in that the surfactant is selected from lauryl hydroxyl
At least one of sulfobetaines, cocounut oil both sexes guanidine-acetic acid sodium or laureth sulfosuccinate disodium；
Preferably, the surfactant includes that lauryl hydroxyl sulfo betaine, cocounut oil both sexes guanidine-acetic acid sodium and laruyl alcohol are poly-
Ether sulfosuccinates disodium；
Preferably, the thickener is sodium alginate；
Preferably, the emulsifier is Tween-80；
Preferably, the moisturizer is glycerine；
Preferably, the preservative is sodium benzoate.
8. according to the preparation method of the clean bacteriostasis spray of claim 1-7 any one of them woman, which is characterized in that including walking as follows
Suddenly：Chinese medical extract, brown alga oligose, borneol, chlorhexidine acetate, optional auxiliary material and water are uniformly mixed, the clean suppression of woman is obtained
Bacterium spray.
9. the preparation method of the clean bacteriostasis spray of woman according to claim 8, which is characterized in that the system of the Chinese medical extract
Preparation Method includes the following steps：
Centella, frutus cnidii, Cortex Phellodendri, kuh-seng, radix scutellariae, rheum officinale and azedarach are added into flooding, filter to take filtered fluid, is concentrated, is done
It is dry, obtain Chinese medical extract.
10. according to application of the claim clean bacteriostasis spray of 1-7 any one of them woman in terms of preventing gynaecological imflammation；
Preferably, the gynaecological imflammation includes vaginitis, cervicitis and pelvic infecton.
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