CN110327246A - A kind of mouthwash containing marine oligosaccharide - Google Patents
A kind of mouthwash containing marine oligosaccharide Download PDFInfo
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- CN110327246A CN110327246A CN201910737335.4A CN201910737335A CN110327246A CN 110327246 A CN110327246 A CN 110327246A CN 201910737335 A CN201910737335 A CN 201910737335A CN 110327246 A CN110327246 A CN 110327246A
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- oligosaccharide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
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Abstract
The invention belongs to oral nursing liquid technical field, it is related to a kind of using marine oligosaccharide as the antibacterial mouthwash of the natural activity of core component, the component of the mouthwash includes: marine oligosaccharide, multi-vitamins, the sterculia seed, sweetener, flavouring agent, potassium sorbate and water.Wherein, marine oligosaccharide mainly extracts small-molecular-weight glucide inside marine animal and plant plant, and sweetener is stevioside, Radix Glycyrrhizae, disodium glycyrrhizinate or tripotassium glycyrrhetate.Mouthwash of the invention is applied widely, easy to use, has the function of cleaning, antibacterial, antiviral, anti-caries and promotes mucous membrane of mouth reparation, without any side effects.
Description
Technical field
The present invention relates to a kind of mouthwashes containing marine oligosaccharide more particularly to a kind of using marine oligosaccharide as core component
The antibacterial mouthwash of natural activity, belongs to field of marine biotechnology.
Background technique
Oral health is one of the big standard of human health ten that the World Health Organization determines, is reflection human health and life
The mirror of quality, oral health and the whole body health entirety that be one inseparable, before oral health is whole body health
It mentions and has left oral health there will be no the body of health, mouth disease can not only cause toothache, masticatory ability decline pronunciation not
Clearly, face appearance is influenced, the germ that the social interaction and Psychology and behavior to people have an impact more seriously mouth disease can also
Cause a variety of systemic diseases, becoming the important risk factor oral healths of many whole body system diseases, it is close with whole body health
Cut phase is closed；But become the something to write home about of many people, Third National as compatriots' living standard increasingly improves oral health issue
There is the puzzlement of 97% adult by different oral problems in oral health epidemiological investigation display China.
Mouthwash is the novel product of Technology Times, and researcher is by a variety for the treatment of oral cavities, the pharmaceutical compositions phases of pharyngolaryngitis
Cooperation, which is developed, can directly act on site of disease, can also remove because of mouth disease, eat peculiar smell foodstuff, dyssomnia, stress, digestion
The mouthwash of halitosis caused by bad etc..
Currently on the market there are also some mouthrinse products with antibacterial and anti-inflammation functions, these products are a small amount of anti-by addition
The chemicals such as raw element kill intraoral bacterium, treat to inflammation and wound.Although these chemicals are imitated
Fruit is obvious, but this mouthwash is used for a long time, and bacterium and virus can be made to generate drug resistance, cause consequence very serious.
Summary of the invention
Aiming at the problems existing in the prior art, the present invention provides a kind of mouthwash containing marine oligosaccharide, this is gargled
Water has good oral cleaning effect, can fresh breath, prevent saprodontia, also there is good anti-bacteria and anti-virus, disappear
Effect that is scorching, repairing mucous membrane of mouth.
In order to achieve the above object, the present invention is achieved through the following technical solutions:
A kind of mouthwash containing marine oligosaccharide, according to mass percent, the component of mouthwash includes: marine oligosaccharide 0.7-
1.1%, multi-vitamins 1.2-2%, sterculia seed 1.5-4%, sweetener 0.05-0.1%, flavouring agent 0.3-0.5%, sorbic acid
Potassium 0.1-0.3%, surplus are pure water.
Preferably, according to mass percent, a kind of component of the mouthwash containing marine oligosaccharide include: marine oligosaccharide 1%,
Multi-vitamins 1.5%, the sterculia seed 2%, sweetener 0.06%, flavouring agent 0.35%, potassium sorbate 0.2%, surplus are pure
Water.
Preferably, marine oligosaccharide selects one or two kinds of mixtures of brown alga oligose and carrageenan oligosaccharide.
Preferably, multi-vitamins be vitamin B2, vitamin C, vitamin E composition by a certain percentage it is a kind of or
The mixture of 2:1:1 in mass ratio；
Preferably, sweetener is one kind of stevioside, Radix Glycyrrhizae, disodium glycyrrhizinate or tripotassium glycyrrhetate or mixes by any mass ratio
Two or more mixtures.
It is further preferred that in marine oligosaccharide brown alga oligose and carrageenan oligosaccharide ratio are as follows: 1:2.
It is further preferred that brown alga oligose selects enzymatic hydrolysis brown alga oligose, molecular weight is between 1000-2000Da；Carragheen
Oligosaccharides selects enzymatic hydrolysis kappa-carrageenin oligose, and molecular weight is less than 1000Da.
A kind of mouthwash containing marine oligosaccharide provided by the invention the preparation method comprises the following steps:
(1) following raw materials: marine oligosaccharide 0.7-1.1%, multi-vitamins 1.2-2%, the sterculia seed are weighed by mass percentage
1.5-4%, sweetener 0.05-0.1%, flavouring agent 0.3-0.5%, potassium sorbate 0.1-0.3%, surplus are pure water.
(2) first marine oligosaccharide is dissolved using 30-50 DEG C of warm water, then be gradually added the sterculia seed, multi-vitamins,
Potassium sorbate, after stirring and dissolving, taste and smell according still further to solution are gradually added sweetener, flavouring agent, finally, by mixed liquor
The membrane filtration that stirring is 0.45um with aperture to after being completely dissolved, obtains filtrate and obtains the mouthwash containing marine oligosaccharide.
The present invention have it is following the utility model has the advantages that
1, in the present invention brown alga oligose used in mouthwash by β-D- polymannuronate (M) and α-L- guluronic acid
(G) brown alga oligose of the linear polymer being made up of Isosorbide-5-Nitrae glycosidic bond, enzymatic hydrolysis has not in oligosaccharides non-reducing end saccharide ring C4, C5
The double bond of saturation all has inducing action, and eight sugar of guluronic acid and seven sugar of mannuronic acid to the release of cell factor
Inducing action is most significant；Moreover, can be combined into ' eggshell case ' with cationic ion netted for the guluronic acid sugar chain of brown alga oligose
Structure, wherein the degree of polymerization is that the guluronic acid oligosaccharide of 5-15 is easier to cation into colloid, to a certain extent can be temporary
Mucin network structure is sexually revised, may have the function for the treatment of oral system mucosa infection and increasing drug permeable membrane absorbing, from
And there is the latent effect for improving drug bioavailability；In addition, brown alga oligose also has including anti-oxidant, antitumor, anticoagulant
The various biologicals activity such as blood, anti-radiation, antifatigue, antibacterial, neuroprotection；
2, another marine oligosaccharide used in mouthwash of the present invention: carrageenan oligosaccharide is with 1,3- β-D- galactolipin and 1,4- α-D
Galactolipin alternately connects a kind of galactan sulfate for forming skeleton structure；The early stage that this sulfated polysaccharide breaks out virosis has
Good therapeutic effect, itself carries negative electrical charge, can directly act on virus surface, has to a variety of viruses containing cyst membrane straight
Connect lethal effect, it made to lose infection ability, in addition, carrageenan oligosaccharide by itself negative electrical charge with sulfate group shield
The positive charge of cell surface is covered, to inhibit virus to the adsorption process of cell；Carrageenan oligosaccharide is to intrinsic coagulation system simultaneously
System tool has certain effect, and this effect is further significant with the increase of sulfur content in oligosaccharides；
3, the sterculia seed has the effect of clearing lung-heat heat, throat, removing toxic substances, relax bowel and defecation, and vitamin can also improve killing for mouthwash
Bacterium effect, flavouring agent can provide faint scent for oral cavity, improve implication；Sweetener can improve the mouthfeel of mouthwash, and
The natural sweetener used will not cause fat or decayed tooth.
4, these substances used in the type mouthwash are mainly extracted from natural materials and are obtained, will not be as antibiotic
Equal chemicals equally generate apparent drug resistance, also very safe to human health.
Specific embodiment
Embodiment 1
A kind of mouthwash containing marine oligosaccharide, the component according to mass percent include: marine oligosaccharide 1%, multi-vitamins
1.5%, the sterculia seed 2%, sweetener 0.06%, flavouring agent 0.35%, potassium sorbate 0.2%, surplus are pure water；
Wherein marine oligosaccharide is brown alga oligose: the mixture of carrageenan oligosaccharide 2:1；
Multi-vitamins are vitamin B2: vitamin C: the mixture of vitamin E 2:1:1；
Sweetener are as follows: stevioside；
The mouthwash containing marine oligosaccharide the preparation method comprises the following steps:
(1) following raw materials: marine oligosaccharide 0.7-1.1%, multi-vitamins 1.2-2%, the sterculia seed are weighed by mass percentage
1.5-4%, sweetener 0.05-0.1%, flavouring agent 0.3-0.5%, potassium sorbate 0.1-0.3%, surplus are pure water.
(2) first marine oligosaccharide is dissolved using 30-50 DEG C of warm water, then be gradually added the sterculia seed, multi-vitamins,
Potassium sorbate, after stirring and dissolving, taste and smell according still further to solution are gradually added sweetener, flavouring agent, finally, will mixing
The membrane filtration that it is 0.45um with aperture to after being completely dissolved that liquid, which is stirred, obtains filtrate and obtains the mouthwash containing marine oligosaccharide.
Embodiment 2
A kind of mouthwash containing marine oligosaccharide, the component according to mass percent include: marine oligosaccharide 1%, multi-vitamins
1.5%, the sterculia seed 2%, sweetener 0.06%, flavouring agent 0.35%, potassium sorbate 0.2%, surplus are pure water；
Wherein marine oligosaccharide is brown alga oligose；
Multi-vitamins are vitamin B2: vitamin C: the mixture of vitamin E 2:1:1；
Sweetener are as follows: stevioside；
The mouthwash containing marine oligosaccharide the preparation method comprises the following steps:
(1) following raw materials: marine oligosaccharide 0.7-1.1%, multi-vitamins 1.2-2%, the sterculia seed are weighed by mass percentage
1.5-4%, sweetener 0.05-0.1%, flavouring agent 0.3-0.5%, potassium sorbate 0.1-0.3%, surplus are pure water.
(2) first marine oligosaccharide is dissolved using 30-50 DEG C of warm water, then be gradually added the sterculia seed, multi-vitamins,
Potassium sorbate, after stirring and dissolving, taste and smell according still further to solution are gradually added sweetener, flavouring agent, finally, will mixing
The membrane filtration that it is 0.45um with aperture to after being completely dissolved that liquid, which is stirred, obtains filtrate and obtains the mouthwash containing marine oligosaccharide.
Embodiment 3
A kind of mouthwash containing marine oligosaccharide, the component according to mass percent include: marine oligosaccharide 1%, multi-vitamins
1.5%, the sterculia seed 2%, sweetener 0.06%, flavouring agent 0.35%, potassium sorbate 0.2%, surplus are pure water；
Wherein marine oligosaccharide is carrageenan oligosaccharide；
Multi-vitamins are vitamin B2: vitamin C: the mixture of vitamin E 2:1:1；
Sweetener are as follows: stevioside；
The mouthwash containing marine oligosaccharide the preparation method comprises the following steps:
(1) following raw materials: marine oligosaccharide 0.7-1.1%, multi-vitamins 1.2-2%, the sterculia seed are weighed by mass percentage
1.5-4%, sweetener 0.05-0.1%, flavouring agent 0.3-0.5%, potassium sorbate 0.1-0.3%, surplus are pure water.
(2) first marine oligosaccharide is dissolved using 30-50 DEG C of warm water, then be gradually added the sterculia seed, multi-vitamins,
Potassium sorbate, after stirring and dissolving, taste and smell according still further to solution are gradually added sweetener, flavouring agent, finally, will mixing
The membrane filtration that it is 0.45um with aperture to after being completely dissolved that liquid, which is stirred, obtains filtrate and obtains the mouthwash containing marine oligosaccharide.
Embodiment 4: mouthwash bacteriostatic test
Bacteriostatic experiment is carried out using 1 gained mouthwash of embodiment as laboratory sample, the bacterial strain used in bacteriostatic experiment is routine
Oral cavity pathogen, comprising: staphylococcus aureus, streptococcus mutans, Escherichia coli and Candida albicans；
Experiment equipment: culture dish, graduated cylinder, dropper, conical flask, LDZX-50FA vertical pressure steam sterilizer, JY2002 electronics day
Flat, digital display constant temperature blender with magnetic force, microscope etc.；
Experimental drug: agar, beef extract, peptone, yeast extract, NaCL, distilled water, bacterium colony culture solution etc.；
Experimental procedure:
1. 8 culture mediums of apparatus and production wash with distilled water；
2. suitably after four kinds of dilution staphylococcus aureus, streptococcus mutans, Escherichia coli and Candida albicans bacterium colony culture mediums,
0.1ml bacterium solution is respectively taken, is inoculated on 8 culture mediums respectively using spread plate method；
3. 8 culture mediums are numbered, and be divided into A(staphylococcus aureus), B(Streptococcus mutans), C(Escherichia coli), D
Four groups of (Candida albicans)；
4. cutting the disk of 16 diameter 2cm with filter paper, will be attached on culture medium after 16 immersion 1 mouth rinse solutions of embodiment,
Every culture medium pastes 2；
5. for a period of time by the culture medium culture marked, observing bacterial growth situation；
6. taking out plate, the diameter of inhibition zone is measured, and is made a record；
7. arranging data, it was therefore concluded that；
Note: inhibition zone radius is denoted as R1;Wafer radius 1cm is denoted as R2
It is above-mentioned the experimental results showed that the application mouthwash have preferable bacteriostasis efficacy, can effectively inhibit Staphylococcus aureus
Bacterium, Streptococcus mutans and Candida albicans etc., effectively nursing oral cavity.
The above examples are only used to illustrate the technical scheme of the present invention, rather than is limited；Although referring to aforementioned reality
It applies example to be described in detail to by invention, but for those of ordinary skill in the art, it still can be to aforementioned reality
Technical solution documented by example is applied to modify or equivalent replacement of some of the technical features；And to these modifications
Or replacement, the spirit and scope for claimed technical solution of the invention that it does not separate the essence of the corresponding technical solution.
Claims (8)
1. a kind of mouthwash containing marine oligosaccharide, it is characterised in that the mass fraction component of mouthwash includes: marine oligosaccharide
0.7-1.1%, multi-vitamins 1.2-2%, sterculia seed 1.5-4%, sweetener 0.05-0.1%, flavouring agent 0.3-0.5%, mountain
Potassium sorbate 0.1-0.3%, surplus are pure water.
2. a kind of mouthwash containing marine oligosaccharide according to claim 1, it is characterised in that the quality of the mouthwash
Number component include: marine oligosaccharide 1%, multi-vitamins 1.5%, the sterculia seed 2%, sweetener 0.06%, flavouring agent 0.35%,
Potassium sorbate 0.2%, surplus are pure water.
3. a kind of mouthwash containing marine oligosaccharide according to claim 1, it is characterised in that the marine oligosaccharide is selected
One or two kinds of mixtures of brown alga oligose and carrageenan oligosaccharide.
4. a kind of mouthwash containing marine oligosaccharide according to claim 1, it is characterised in that the multi-vitamins are
Vitamin B2, vitamin C, vitamin E composition by a certain percentage is a kind of or the mixture of 2:1:1 in mass ratio.
5. a kind of mouthwash containing marine oligosaccharide according to claim 1, it is characterised in that the sweetener is stevia rebaudianum
Sugar, Radix Glycyrrhizae, one kind of disodium glycyrrhizinate or tripotassium glycyrrhetate or the two or more mixtures that are mixed by any mass ratio.
6. a kind of mouthwash containing marine oligosaccharide according to claim 1, it is characterised in that brown in the marine oligosaccharide
The ratio of algae oligosaccharides and carrageenan oligosaccharide are as follows: 1:2.
7. a kind of mouthwash containing marine oligosaccharide according to claim 6, it is characterised in that the brown alga oligose is selected
Brown alga oligose is digested, molecular weight is between 1000-2000Da；Carrageenan oligosaccharide selects enzymatic hydrolysis kappa-carrageenin oligose, and molecular weight is small
In 1000Da.
8. a kind of mouthwash containing marine oligosaccharide according to claim 1, it is characterised in that described to contain marine oligosaccharide
Mouthwash the preparation method comprises the following steps:
(1) following raw materials: marine oligosaccharide 0.7-1.1%, multi-vitamins 1.2-2%, the sterculia seed are weighed by mass percentage
1.5-4%, sweetener 0.05-0.1%, flavouring agent 0.3-0.5%, potassium sorbate 0.1-0.3%, surplus are pure water；
(2) first marine oligosaccharide is dissolved using 30-50 DEG C of warm water, then is gradually added the sterculia seed, multi-vitamins, sorb
Sour potassium, after stirring and dissolving, taste and smell according still further to solution are gradually added sweetener, flavouring agent, finally, mixed liquor is stirred
The membrane filtration for being 0.45um with aperture to after being completely dissolved obtains filtrate and obtains the mouthwash containing marine oligosaccharide.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110946804A (en) * | 2020-01-06 | 2020-04-03 | 王爱芹 | Mouthwash for preventing dental caries and oral ulcer and preparation method thereof |
| CN112370426A (en) * | 2019-12-27 | 2021-02-19 | 青岛博智汇力生物科技有限公司 | Marine oligosaccharide oral spray |
| CN112494361A (en) * | 2020-12-28 | 2021-03-16 | 青岛博智汇力生物科技有限公司 | Antibacterial and anti-radiation marine oligosaccharide isolation emulsion and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110946804A (en) * | 2020-01-06 | 2020-04-03 | 王爱芹 | Mouthwash for preventing dental caries and oral ulcer and preparation method thereof |
| CN112494361A (en) * | 2020-12-28 | 2021-03-16 | 青岛博智汇力生物科技有限公司 | Antibacterial and anti-radiation marine oligosaccharide isolation emulsion and preparation method thereof |
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