CN107753398A - A kind of antibacterial mouthwash of anti-inflammatory and preparation method thereof - Google Patents
A kind of antibacterial mouthwash of anti-inflammatory and preparation method thereof Download PDFInfo
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- CN107753398A CN107753398A CN201711033937.9A CN201711033937A CN107753398A CN 107753398 A CN107753398 A CN 107753398A CN 201711033937 A CN201711033937 A CN 201711033937A CN 107753398 A CN107753398 A CN 107753398A
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- Prior art keywords
- inflammatory
- mouthwash
- antibacterial mouthwash
- antibacterial
- lysozyme
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Abstract
The present invention relates to antibacterial mouthwash of a kind of anti-inflammatory and preparation method thereof, belong to pharmaceutical chemistry technical field.The antibacterial mouthwash of anti-inflammatory includes sweetener, honeysuckle, Chinese gall, lysozyme, vitamin C, essence, pure water.The present invention is by the natural component with bacteriostatic activity, as lysozyme, Chinese gall are added in mouthwash, existing medicine and disinfectant are instead of, its composition is gentle, mucous membrane of mouth will not be damaged antibacterial while, simultaneously, the root of Dahurain angelica of the extraction with anti-inflammatory whitening function, the active ingredient in honeysuckle, are made extract solution, are added in mouthwash, prevention oral inflammation can be reached while oral cavity is cleaned, the effect of tooth-whitening.
Description
Technical field
The present invention relates to antibacterial mouthwash of a kind of anti-inflammatory and preparation method thereof, belong to pharmaceutical chemistry technical field.
Background technology
Oral problem almost annoyings everyone, and the lighter's tooth is dark yellow, influences attractive in appearance；Severe one is with dental caries, dental pulp root
Periapical desease, gingivitis, periodontitis, pericoronitis of the third molar of the mandible, mandibular osteomyelitis etc., make us suffering untold misery.
The big main cause that oral problem is formed is exactly that can not clean oral cavity in time after the meal, and the food of residual is residual in slot
Slag becomes the hotbed of Bacteria Culture, meanwhile, swill, dna exogenous pigment etc. are bonded in tooth by the emplastic of bacterial secretory
Tooth surface, bacterial plaque is formed, influence attractive in appearance, severe patient's induction oral inflammation, in addition, containing substantial amounts of in some tooth whitening products
Rubbing agent or strong oxidizing property composition, the composition can effectively remove the pigment of dental surface, although having reached the effect of tooth whitening
Fruit, but long-term use can damage enamel, tooth is become sensitive, or cause oral mucosa lesion.
In order to reach the purpose for cleaning oral cavity whenever and wherever possible, mouthwash arises at the historic moment.Originally, using the purpose of mouthwash
Be only that is inconvenient to the occasion fresh breath brushed teeth at some, keeps breath freshening；To reach the mesh for the bacterium that prevents from decaying tooth, suppress
, some fluorides or alcohol can be also added in mouthwash, triclosan, chlorhexidine can be also added in some mouthwashes, wash must
The disinfection compositions such as Thailand, although the composition can play antibacterial effect, certain injury and simultaneously discomfort can be also caused to oral cavity
The crowds such as children, pregnant woman or driver are closed to use.
The content of the invention
The present invention solves the problems, such as that existing mouthwash is present by adding many kinds of substance in existing mouthwash.
The invention provides a kind of antibacterial mouthwash of anti-inflammatory, the antibacterial mouthwash of anti-inflammatory includes sweetener, honeysuckle, five
Gall nut, lysozyme, vitamin C, essence, pure water.
It is honeysuckle gas delicate fragrance of the present invention, sweet, can be clearing heat and detoxicating, wind-heat dissipating, the effect of reducing internal heat with anti-inflammatory.
Gallic main component of the present invention is tannic acid, tannic acid to common oral cavity pathogen, such as：Deformation
Streptococcus, actinomyces viscosus, porphyromonas gingivalis, Fusobacterium nucleatum, enterococcus faecalis etc. play the role of suppression.
Lysozyme of the present invention is also known as muramidase or N-acetylmuramide lycanohydrlase, is that a kind of can hydrolyze is caused a disease
The alkaline enzyme of polysaccharide is sticked in bacterium, lysozyme is by destroying between the -acetylmuramic acid in cell membrane and NAG
β-Isosorbide-5-Nitrae glycosidic bond, the insoluble glutinous polysaccharide of cell membrane is resolved into soluble glycopeptide, cause cell wall rupture content to escape and make
Bacterolysis, lysozyme can also with negatively charged virus protein directly in conjunction with, with DNA, RNA, apoprotein formed double salt,
Make it is virally inactivated, therefore, lysozyme have antibacterial, anti-inflammatory, antiviral etc. effect.
Vitamin C of the present invention has enhancing immunity of organisms, antiallergic sense, promotes ossein synthesis, alleviation gum to go out
Blood, promote the effect of calcium absorption, treatment canker sore.
The antibacterial mouthwash of anti-inflammatory of the present invention is preferably by weight, to be made up of following components：
Sweetener of the present invention is preferably non-sugar sweetener, more preferably xylitol, D-sorbite, erythrose
At least one of alcohol, maltitol, Sucralose, Aspartame and acesulfame potassium, such sweetener can not be utilized by microorganism,
It will not cause to decay tooth after into oral cavity, can pre- anti-caries.
Essence of the present invention is preferably soluble perfume.
The antibacterial mouthwash of anti-inflammatory of the present invention preferably comprises sweetener, NMF, honeysuckle, the root of Dahurain angelica, Chinese gall, molten
Bacterium enzyme, sodium phytate, vitamin C, essence, pure water.
The root of Dahurain angelica of the present invention has the effect of hemostasis, promoting blood circulation, analgesia, and is usually used in skin-lightening cosmetic, makes skin beautiful
In vain.
Sodium phytate of the present invention can chelate dna exogenous pigment, promote pigment to come off.
The antibacterial mouthwash of anti-inflammatory of the present invention is preferably by weight, to be made up of following components：
NMF of the present invention is preferably at least one of glycerine, propane diols and D-sorbite.
Another object of the present invention is to provide a kind of preparation method of the above-mentioned antibacterial mouthwash of anti-inflammatory, the preparation method bag
Include following steps：
1. pressing predetermined weight part, sweetener, NMF, honeysuckle, the root of Dahurain angelica, Chinese gall, lysozyme, sodium phytate, dimension life are taken
Plain C, essence, pure water；
2. honeysuckle, the root of Dahurain angelica, Chinese gall are decocted in water, filter, concentration；
3. sweetener, NMF, lysozyme, sodium phytate, vitamin C, essence are dissolved in pure water, stir to clarify；
4. 2. 3. solution that step is obtained with step mixes, filtered, obtained using the miillpore filter that aperture is 0.45 μm
The antibacterial mouthwash of anti-inflammatory.
2. step of the present invention decocts preferably twice, decoct 30-90min, second of decoction 30-90min for the first time,
Mix decoction liquor twice.
The present invention has the beneficial effect that：
Natural component with bacteriostatic activity, such as lysozyme, Chinese gall are added in mouthwash by the present invention, instead of existing
Some medicine and disinfectant, its composition is gentle, mucous membrane of mouth will not be damaged antibacterial while, meanwhile, extraction has
Active ingredient in the root of Dahurain angelica of anti-inflammatory whitening function, honeysuckle, is made extract solution, is added in mouthwash, in cleaning oral cavity
Simultaneously prevention oral inflammation can be reached, the effect of tooth-whitening.
Embodiment
Following non-limiting examples can make one of ordinary skill in the art be more fully understood the present invention, but not with
Any mode limits the present invention.
Embodiment 1
A kind of preparation method of the antibacterial mouthwash of anti-inflammatory, the preparation method comprise the following steps：
1. by weight, take 100 parts of xylitols, 50 parts of glycerine, 30 portions of honeysuckles, 150 portions of Chinese galls, 5 parts of lysozymes, 5
Part vitamin C, 5 parts of peppermint liquid essences, 500 parts of pure water；
2. honeysuckle, Chinese gall are cleaned, 30min is soaked in water, is decocted twice, decocts 60min for the first time, for the second time
60min is decocted, mixes decoction liquor twice, is filtered, concentration；
3. xylitol, glycerine, lysozyme, vitamin C, peppermint liquid essence are dissolved in pure water, stir to clarify；
4. 2. 3. solution that step is obtained with step mixes, filtered using the miillpore filter that aperture is 0.45 μm, it is filling,
Obtain the antibacterial mouthwash of anti-inflammatory.
Embodiment 2
A kind of preparation method of the antibacterial mouthwash of anti-inflammatory, the preparation method comprise the following steps：
1. by weight, take 100 parts of xylitols, 30 parts of glycerine, 50 portions of honeysuckles, 50 portions of Chinese galls, 10 parts of lysozymes, 5
Part sodium phytate, 5 parts of vitamin Cs, 1 part of Sucralose, 10 parts of honey peach liquid essences, 550 parts of pure water；
2. honeysuckle, Chinese gall are cleaned, 30min is soaked in water, is decocted twice, decocts 60min for the first time, for the second time
60min is decocted, mixes decoction liquor twice, is filtered, concentration；
3. xylitol, glycerine, lysozyme, sodium phytate, vitamin C, Sucralose, honey peach liquid essence are dissolved in pure
In water, stir to clarify；
4. 2. 3. solution that step is obtained with step mixes, filtered using the miillpore filter that aperture is 0.45 μm, it is filling,
Obtain the antibacterial mouthwash of anti-inflammatory.
Embodiment 3
A kind of preparation method of the antibacterial mouthwash of anti-inflammatory, the preparation method comprise the following steps：
1. by weight, take 100 parts of xylitols, 50 parts of glycerine, 50 portions of honeysuckles, 50 parts of roots of Dahurain angelica, 50 portions of Chinese galls, 5 parts
Lysozyme, 10 parts of sodium phytates, 5 parts of vitamin Cs, 10 parts of green tea liquid essence, 400 parts of pure water；
2. honeysuckle, the root of Dahurain angelica, Chinese gall are cleaned, 30min is soaked in water, decocts twice, decocts 60min for the first time,
Second of decoction 60min, mixes decoction liquor twice, filters, concentration；
3. xylitol, glycerine, lysozyme, sodium phytate, vitamin C, green tea liquid essence are dissolved in pure water, stirring is extremely
Clarification；
4. 2. 3. solution that step is obtained with step mixes, filtered using the miillpore filter that aperture is 0.45 μm, it is filling,
Obtain the antibacterial mouthwash of anti-inflammatory.
Application examples 1
The influence of the antibacterial mouthwash of anti-inflammatory prepared by above-described embodiment 1-3 to dental plaque index
Recruit 100 volunteers to be tested, preliminary examination is carried out before testing, it is complete to choose denture, and 2 weeks not before experiment
Antibiotics was taken, was not in during orthodontic treatment, no Specific weight periodontosis and oral mucosal disease, no whole body system
The volunteer of disease, the measure of Dental Plaque index and index of gingivitis is carried out to it, finally selected plaque index and index of gingivitis
Similar 60 volunteers participate in experiment, and subjects the range of age 20-40 year, men and women half and half, by choose 60 subjects
It is equally divided into 5 groups, there was no significant difference for the plaque index of every group of subject and the average value of index of gingivitis.
Plaque index is dyed to supragingival plaque and remembered according to following standard using the Turesky plaque indexs measurement of improvement
Record：
0=is without bacterial plaque；
The bacterial plaque that 1=necks portion marginal existence is dispersed in；
The visible continuous thin bacterial plaque band (wide up to 1mm) of 2=tooth neck edges；
3=necks portion bacterial plaque band is more than 1mm, but less than the 1/3 of pressure surface；
4=bacterial plaques cover the 1/3-2/3 of facing；
More than the 2/3 of 5=bacterial plaques covering facing.
For index of gingivitis using the Loe-Silness index of gingivitis measurement of improvement, gingivitis evaluation method and standard are as follows：
0=is without oulitis；
Oulitis that 1=is slight, gum color and luster and quality are slightly changed, but are visited and examined no bleeding；
2=moderate inflammations, gum is bright, red and swollen, and bleeding is examined in hyperplasia, spy；
3=hyperphlogosises, gum is substantially rubescent, hyperplasia, there is hematostaxis.
Every subject's buccal surface and lingual surface oulitis situation are recorded, a tooth bilateral maximum count is 6, except third molar, vacation
Tooth and the tooth for having neck reparation, remaining tooth are included in the row of counting, and the mean of index of gingivitis is by personal whole tooth detections
Gained counts sum divided by total measurement number obtains.
The Buccodental and lingual surface of subject is checked, bilateral maximum plaque index is 10, except third molar, artificial tooth and neck
There is the tooth of reparation, remaining tooth is recorded, and the mean of each subject's plaque index is succeeded in one's scheme by personal whole tooth detections
Number sum divided by total measurement number obtain.
The mouthwash of the preparation of embodiment 1, mouthwash prepared by embodiment 2, reality is respectively adopted in 5 groups of subjects during experiment
The mouthwash, pure water, commercially available mouthwash for applying the preparation of example 3 are tested, and every group of subject is respectively at the early postprandial, noon during experiment
After the meal, adopt after dinner and gargle in a like fashion, mode of gargling first to be gargled 1 time using clear water, then using mouthwash to be measured or
Pure water spues in mouth after buccal 30s.In addition, during experiment, subject is brushed teeth using identical toothbrush and toothpaste, often
It respectively brushes teeth 1 time, each 3min sooner or later, meanwhile, forbid taking antibiotics during experiment.
After testing 8 weeks, subject's index of gingivitis and plaque index are determined again, data are united using SPSS software kits
Credit analysis is counted, according to data distribution situation, the data before testing each group subject, after experiment 8 weeks carry out t inspections, p ＜ 0.05
There is conspicuousness for difference, analysis result is shown in Table 1, table 2.
The plaque index measurement result of table 1
| Group | Before experiment | After testing 8 weeks |
| Mouthwash group prepared by embodiment 1 | 2.73±0.04 | 2.39±0.18 |
| Mouthwash group prepared by embodiment 2 | 2.73±0.03 | 2.15±0.19 |
| Mouthwash group prepared by embodiment 3 | 2.74±0.07 | 1.52±0.21 |
| Pure water group | 2.73±0.08 | 2.81±0.24 |
| Commercially available mouthwash group | 2.72±0.12 | 2.46±0.22 |
The index of gingivitis measurement result of table 2
| Group | Before experiment | After testing 8 weeks |
| Mouthwash group prepared by embodiment 1 | 1.5±0.09 | 1.27±0.17 |
| Mouthwash group prepared by embodiment 2 | 1.51±0.07 | 1.09±0.13 |
| Mouthwash group prepared by embodiment 3 | 1.5±0.08 | 0.63±0.08 |
| Pure water group | 1.51±0.06 | 1.47±0.05 |
| Commercially available mouthwash group | 1.5±0.09 | 1.36±0.13 |
Obtained by the measurement result of above-mentioned plaque index, before the test, plaque index and index of gingivitis are close between each group, show
Work property analysis result shows that there was no significant difference between each group (p ＞ 0.05), and after testing 8 weeks, prepared by embodiment 1,2,3 gargles
Water group and commercially available mouthwash group can substantially reduce oral plaque, and pure water group and the plaque index phase of tested preceding sample
Than, it is increased slightly, but gather way slowly, the production of bacterial plaque can be alleviated to a certain extent by illustrating to gargle only with pure water
It is raw, but not reduce existing bacterial plaque.
Obtained by the measurement result of above-mentioned index of gingivitis, mouthwash group and commercially available mouthwash group prepared by embodiment 1,2,3 is equal
Oral inflammation can be alleviated to some extent, there was no significant difference (p ＞ 0.05) compared with before testing for the measurement result of pure water group, its
In, mouthwash prepared by embodiment 3 employs Multiple components compounding, significantly improves the inhibiting bacteria and diminishing inflammation effect of one-component, dashes forward
The Synergistic gone out between each composition.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art in the technical scope of present disclosure, technique according to the invention scheme and its
Inventive concept is subject to equivalent substitution or change, should all be included within the scope of the present invention.
Claims (10)
- A kind of 1. antibacterial mouthwash of anti-inflammatory, it is characterised in that：The antibacterial mouthwash of anti-inflammatory include sweetener, honeysuckle, five times Son, lysozyme, vitamin C, essence, pure water.
- 2. the antibacterial mouthwash of anti-inflammatory according to claim 1, it is characterised in that：The antibacterial mouthwash of anti-inflammatory, by weight Part, it is made up of following components：
- 3. the antibacterial mouthwash of anti-inflammatory according to claim 2, it is characterised in that：The sweetener is non-sugar sweetener.
- 4. the antibacterial mouthwash of anti-inflammatory according to claim 3, it is characterised in that：The sweetener is xylitol, sorbose At least one of alcohol, antierythrite, maltitol, Sucralose, Aspartame and acesulfame potassium.
- 5. the antibacterial mouthwash of anti-inflammatory according to claim 4, it is characterised in that：The essence is soluble perfume.
- 6. the antibacterial mouthwash of anti-inflammatory according to claim 5, it is characterised in that：The antibacterial mouthwash of anti-inflammatory includes sweet taste Agent, NMF, honeysuckle, the root of Dahurain angelica, Chinese gall, lysozyme, sodium phytate, vitamin C, essence, pure water.
- 7. the antibacterial mouthwash of anti-inflammatory according to claim 6, it is characterised in that：The antibacterial mouthwash of anti-inflammatory, by weight Part, it is made up of following components：
- 8. the antibacterial mouthwash of anti-inflammatory according to claim 7, it is characterised in that：The NMF be glycerine, propane diols and At least one of D-sorbite.
- 9. the preparation method of the antibacterial mouthwash of the anti-inflammatory of claim 1,2,3,4,5,6,7 or 8, it is characterised in that：The system Preparation Method comprises the following steps：1. press predetermined weight part, take sweetener, NMF, honeysuckle, the root of Dahurain angelica, Chinese gall, lysozyme, sodium phytate, vitamin C, Essence, pure water；2. honeysuckle, the root of Dahurain angelica, Chinese gall are decocted in water, filter, concentration；3. sweetener, NMF, lysozyme, sodium phytate, vitamin C, essence are dissolved in pure water, stir to clarify；4. 2. 3. solution that step is obtained with step mixes, filtered using the miillpore filter that aperture is 0.45 μm, obtain anti-inflammatory Antibacterial mouthwash.
- 10. preparation method according to claim 9, it is characterised in that：2. the step decocts twice, decoct for the first time 30-90min, second of decoction 30-90min, mixes decoction liquor twice.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711033937.9A CN107753398A (en) | 2017-10-30 | 2017-10-30 | A kind of antibacterial mouthwash of anti-inflammatory and preparation method thereof |
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| CN201711033937.9A CN107753398A (en) | 2017-10-30 | 2017-10-30 | A kind of antibacterial mouthwash of anti-inflammatory and preparation method thereof |
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| CN107753398A true CN107753398A (en) | 2018-03-06 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110327246A (en) * | 2019-08-12 | 2019-10-15 | 青岛博智汇力生物科技有限公司 | A kind of mouthwash containing marine oligosaccharide |
| CN113456518A (en) * | 2021-07-16 | 2021-10-01 | 北京洗得宝消毒制品有限公司 | Composite polypeptide mouthwash and preparation method thereof |
| CN113662897A (en) * | 2021-10-08 | 2021-11-19 | 利川市常大产业技术研究院有限公司 | Mouthwash and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110327246A (en) * | 2019-08-12 | 2019-10-15 | 青岛博智汇力生物科技有限公司 | A kind of mouthwash containing marine oligosaccharide |
| CN113456518A (en) * | 2021-07-16 | 2021-10-01 | 北京洗得宝消毒制品有限公司 | Composite polypeptide mouthwash and preparation method thereof |
| CN113662897A (en) * | 2021-10-08 | 2021-11-19 | 利川市常大产业技术研究院有限公司 | Mouthwash and preparation method thereof |
| CN113662897B (en) * | 2021-10-08 | 2023-02-28 | 利川市常大产业技术研究院有限公司 | Mouthwash and preparation method thereof |
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Application publication date: 20180306 |