CN106580769A - Bacteriostatic and tooth-protecting toothpaste - Google Patents
Bacteriostatic and tooth-protecting toothpaste Download PDFInfo
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- CN106580769A CN106580769A CN201611109935.9A CN201611109935A CN106580769A CN 106580769 A CN106580769 A CN 106580769A CN 201611109935 A CN201611109935 A CN 201611109935A CN 106580769 A CN106580769 A CN 106580769A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention provides bacteriostatic and tooth-protecting toothpaste. Through a compound synergistic effect of components in the toothpaste, the effect of killing oral harmful bacteria can be effectively achieved, and the irritation on oral mucosa is small; the active components A, B and C in the toothpaste can become a natural preservative in the toothpaste through the synergistic effect, and can act on cell membranes of the bacteria in the oral cavity, then destroy the integrity of the cell membranes and generate perforated holes so as to enable cell contents to overflow out of cells for causing cell death; or antibacterial peptides act on membrane proteins to cause agglomeration, inactivation and ion channels so as to cause membrane permeability change for causing bacterial death; and therefore, the toothpaste can effectively control the number of pathogenic bacteria in the oral cavity and is of great significance for preventing and treating common oral problems and diseases.
Description
Technical field
The present invention relates to daily-use chemical industry technical field, and in particular to a kind of bacteriostatic tooth protective toothpaste.
Background technology
Aerobe, a small amount of anaerobe and some mycetes, different colony balance growths are there is in the oral cavity of health.Such as
Really this poised state is broken, and some pathogenic bacterium quantity increase, and will provide for common oral problem and disease
Necessary condition.For example, the antibacterial in bacterial plaque especially anaerobe and its product be cause gingivitiss, periodontal disease it is main because
Element, it connects each other, interacts as initiation factor and other factorses, affects generation, the development of periodontal disease;And for example, carefully
Bacterium factor (mainly Streptococcus mutans) cause dental caries three big factors (bacterium factors, food factor, host's tooth and
Saliva factor) in play the big factor of central role, i.e., three worked by antibacterial.
Therefore, efficiently control the oral problem common for preventing and treating of pathogenic bacterium quantity in oral cavity and disease makes great sense.
Add some antibiotic substance in toothpaste this common oral cleaning nursing article, be pathogenic bacterium quantity in effective control oral cavity
A kind of convenient effective approach.
The content of the invention
In view of this, the present invention provides a kind of bacteriostatic tooth protective toothpaste, by the antibacterial toothpaste of the present invention, can effectively control
Pathogenic bacterium quantity in donsole chamber, the oral problem and disease common for preventing and treating makes great sense.
The technical scheme is that：A kind of bacteriostatic tooth protective toothpaste, is made up of following parts by weight meter raw material：Particle diameter is
The hydrated silica 6-9 of 100 mesh, silica 1 1-15, pteria martensii shell powder 13-21, dicalcium phosphate dehydrate 8-14,
Hydroxy-methyl cellulose sodium 5-9, xylitol 23-37 parts, carrageenan 0.1-0.5, xanthan gum 0.2-0.7, C12 alkyl sugar
Glycosides 2-5, cocos nucifera oil acyl CAB 0.3-0.9, flower color glycosides 2-4, mountain bluish red element 2-4, coriander quintessence oil 0.9-1.3,
Lycopene 1-2, active components A 11-17, active component B 13-19, active component C 7-11；The active component A is narrow
Leaf hopea hainanensis crude extract；Active component C is Musca domestica larvae.
Further, the particle diameter of the pteria martensii conch meal powder is 80-120 mesh.
Further, the preparation method of the active component A is：Its is biological for holding for the hopea chinensis vegetable material of collection
Learn growth vigor and prune waste material gained, the vegetable material of collection is placed at room ventilation and is dried in the shade, then in 50 DEG C of constant temperature air blast
Fully it is dried in drying baker, is crushed with plant pulverizer, with the screen filtration of 150 mesh, collects the ultra-micro powder after sieving, it is standby
With；Aqueous two-phase extraction solvent, solid-liquid ratio 1: 40g/ are prepared by 60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate
ML prepares aqueous two-phase extraction solvent, and 30 min are soaked at 60 DEG C, and 50min is then extracted under ultrasonic extraction instrument, and condition is change
Width bar 6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and is removed solid
Body precipitates slag, and filtrate is placed in into concentrating under reduced pressure in Multi-example Parallel evaporator, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 12% Radix Scutellariae, 26% Herba Euphorbiae Humifusae, 18% old
Stork grass, 14% Radix Sanguisorbae, 30% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Musca domestica larva is taken, with distilled water flushing 3 times, Ran Houyong
Filter paper dips in dry polypide, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is extracted according to polypide quality and extracting liquid volume ratio
Liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) is worm
Body is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min High speed refrigerated centrifuges
Supernatant is collected after middle centrifugation 30min, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in into 100 DEG C of perseverances
Heated and stirred 5min in warm water bath, then treats its cooling 10min, then Aspirate supernatant is in 4800r/min high speed frozen centrifugations
30min is centrifuged in machine, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators,
As active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
The beneficial effects of the present invention is：
Aerobe, a small amount of anaerobe and some mycetes, different colony balance growths are there is in the oral cavity of health.If this
Plant poised state to be broken, some pathogenic bacterium quantity increase, and will be common mouth
The generation of chamber problem and disease provides necessary condition.For example, the antibacterial in bacterial plaque especially anaerobe and its product are
Cause the principal element of gingivitiss, periodontal disease, it is mutual with other factorses as initiation factor
Contact, interaction, affect generation, the development of periodontal disease；And for example, bacterium factors (mainly Streptococcus mutans) exist
Central role, i.e., three are played in the three big factors (bacterium factors, food factor, host's tooth and saliva factor) for causing dental caries
Big factor is worked by antibacterial.
Acted on by the compound synergic of each component in the present invention, the work for killing oral cavity noxious bacteria can be effectively accomplished
With, while, active component A, active component B and active component C synergism in the present invention little to oral cavity irritation on mucous membrane,
Can become the natural antiseptic agent in toothpaste, and can act on the cell membrane of antibacterial in oral cavity, then destroy its integrity
And perforation is produced, cause cohesion, inactivation so as to cause the cellular content extracellular and dead or antibacterial peptide of spilling to act on memebrane protein
And ion channel, cause membrane permeability to change and cause bacterial death, pathogenic bacterium quantity in oral cavity can be efficiently controlled, for anti-
Control common oral problem and disease makes great sense
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with the embodiment of the present invention, it is clear that retouched
The embodiment stated is only a part of embodiment of the invention, rather than the embodiment of whole.Based on the embodiment in the present invention, this
The every other embodiment that field those of ordinary skill is obtained under the premise of creative work is not made, belongs to the present invention
The scope of protection.
Embodiment 1
A kind of bacteriostatic tooth protective toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, silicon dioxide of 100 mesh
13rd, pteria martensii shell powder 16, dicalcium phosphate dehydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carrageenan
0.3rd, xanthan gum 0.4, C12 alkyl polyglucoside 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, mountain bluish red element 3, Yuan
Sui quintessence oils 1.1, lycopene 1.3, active components A 13, active component B 16, active component C 9；The active component A is
Hopea chinensis crude extract；Active component C is Musca domestica larvae.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from Fructus Myricae rubrae.
Further, the particle diameter of the pteria martensii conch meal powder is 110 mesh.
Further, the preparation method of the active component A is：Its is biological for holding for the hopea chinensis vegetable material of collection
Learn growth vigor and prune waste material gained, the vegetable material of collection is placed at room ventilation and is dried in the shade, then in 50 DEG C of constant temperature air blast
Fully it is dried in drying baker, is crushed with plant pulverizer, with the screen filtration of 150 mesh, collects the ultra-micro powder after sieving, it is standby
With；Aqueous two-phase extraction solvent, solid-liquid ratio 1: 40g/ are prepared by 60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate
ML prepares aqueous two-phase extraction solvent, and 30 min are soaked at 60 DEG C, and 50min is then extracted under ultrasonic extraction instrument, and condition is change
Width bar 6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and is removed solid
Body precipitates slag, and filtrate is placed in into concentrating under reduced pressure in Multi-example Parallel evaporator, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 12% Radix Scutellariae, 26% Herba Euphorbiae Humifusae, 18% old
Stork grass, 14% Radix Sanguisorbae, 30% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Musca domestica larva is taken, with distilled water flushing 3 times, Ran Houyong
Filter paper dips in dry polypide, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is extracted according to polypide quality and extracting liquid volume ratio
Liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) is worm
Body is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min High speed refrigerated centrifuges
Supernatant is collected after middle centrifugation 30min, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in into 100 DEG C of perseverances
Heated and stirred 5min in warm water bath, then treats its cooling 10min, then Aspirate supernatant is in 4800r/min high speed frozen centrifugations
30min is centrifuged in machine, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators,
As active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Bacteriostatic tooth protective toothpaste of the present invention can adopt completely the conventional method of this area to prepare, such as《Detergent compositions technique
Handbook》(Xu Baocai etc. writes, Chemical Industry Press, chemistry and applied chemistry publishing centre, January the 1st edition in 2006
) toothpaste making process disclosed in the 594-597 page is prepared.Specifically, the preparation of the present embodiment bacteriostatic tooth protective toothpaste
Method is：After above-mentioned raw materials component is weighed, dispersion, mixing in pre-dispersed kettle are opened cream kettle vacuum pump processed and suck above-mentioned liquid
Material, then drives scraper, agitator and colloid mill, closes colloid mill, agitator and scraper after 50 minutes successively, and vacuum breaker is obtained
Bacteriostatic tooth protective toothpaste.
Obviously, in the present invention the preparation method of toothpaste is prior art, not special character, and the present invention's mainly changes
Enter to be that the difference of formula.
Embodiment 2
A kind of bacteriostatic tooth protective toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 6, silicon dioxide of 100 mesh
11st, pteria martensii shell powder 13, dicalcium phosphate dehydrate 8, hydroxy-methyl cellulose sodium 5,23 parts of xylitol, carrageenan
0.1st, xanthan gum 0.2, C12 alkyl polyglucoside 2, cocos nucifera oil acyl CAB 0.3, flower color glycosides 2, mountain bluish red element 2, Yuan
Sui quintessence oils 0.9, lycopene 1, active components A 11, active component B 13, active component C 7；The active component A is narrow
Leaf hopea hainanensis crude extract；Active component C is Musca domestica larvae.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from Rhizoma Dioscoreae esculentae.
Further, the particle diameter of the pteria martensii conch meal powder is 120 mesh.
Further, the preparation method of the active component A is：Its is biological for holding for the hopea chinensis vegetable material of collection
Learn growth vigor and prune waste material gained, the vegetable material of collection is placed at room ventilation and is dried in the shade, then in 50 DEG C of constant temperature air blast
Fully it is dried in drying baker, is crushed with plant pulverizer, with the screen filtration of 150 mesh, collects the ultra-micro powder after sieving, it is standby
With；Aqueous two-phase extraction solvent, solid-liquid ratio 1: 40g/ are prepared by 60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate
ML prepares aqueous two-phase extraction solvent, and 30 min are soaked at 60 DEG C, and 50min is then extracted under ultrasonic extraction instrument, and condition is change
Width bar 6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and is removed solid
Body precipitates slag, and filtrate is placed in into concentrating under reduced pressure in Multi-example Parallel evaporator, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 12% Radix Scutellariae, 26% Herba Euphorbiae Humifusae, 18% old
Stork grass, 14% Radix Sanguisorbae, 30% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Musca domestica larva is taken, with distilled water flushing 3 times, Ran Houyong
Filter paper dips in dry polypide, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is extracted according to polypide quality and extracting liquid volume ratio
Liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) is worm
Body is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min High speed refrigerated centrifuges
Supernatant is collected after middle centrifugation 30min, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in into 100 DEG C of perseverances
Heated and stirred 5min in warm water bath, then treats its cooling 10min, then Aspirate supernatant is in 4800r/min high speed frozen centrifugations
30min is centrifuged in machine, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators,
As active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Embodiment 3
A kind of bacteriostatic tooth protective toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 9, silicon dioxide of 100 mesh
15th, pteria martensii shell powder 21, dicalcium phosphate dehydrate 14, hydroxy-methyl cellulose sodium 9,37 parts of xylitol, carrageenan
0.5th, xanthan gum 0.7, C12 alkyl polyglucoside 5, cocos nucifera oil acyl CAB 0.9, flower color glycosides 4, mountain bluish red element 4, coriander
Quintessence oil 1.3, lycopene 2, active components A 17, active component B 19, active component C 11；The active component A is narrow
Leaf hopea hainanensis crude extract；Active component C is Musca domestica larvae.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from purple cabbage.
Further, the particle diameter of the pteria martensii conch meal powder is 80 mesh.
Further, the preparation method of the active component A is：Its is biological for holding for the hopea chinensis vegetable material of collection
Learn growth vigor and prune waste material gained, the vegetable material of collection is placed at room ventilation and is dried in the shade, then in 50 DEG C of constant temperature air blast
Fully it is dried in drying baker, is crushed with plant pulverizer, with the screen filtration of 150 mesh, collects the ultra-micro powder after sieving, it is standby
With；Aqueous two-phase extraction solvent, solid-liquid ratio 1: 40g/ are prepared by 60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate
ML prepares aqueous two-phase extraction solvent, and 30 min are soaked at 60 DEG C, and 50min is then extracted under ultrasonic extraction instrument, and condition is change
Width bar 6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and is removed solid
Body precipitates slag, and filtrate is placed in into concentrating under reduced pressure in Multi-example Parallel evaporator, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 12% Radix Scutellariae, 26% Herba Euphorbiae Humifusae, 18% old
Stork grass, 14% Radix Sanguisorbae, 30% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Musca domestica larva is taken, with distilled water flushing 3 times, Ran Houyong
Filter paper dips in dry polypide, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is extracted according to polypide quality and extracting liquid volume ratio
Liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) is worm
Body is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min High speed refrigerated centrifuges
Supernatant is collected after middle centrifugation 30min, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in into 100 DEG C of perseverances
Heated and stirred 5min in warm water bath, then treats its cooling 10min, then Aspirate supernatant is in 4800r/min high speed frozen centrifugations
30min is centrifuged in machine, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators,
As active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Embodiment 4
A kind of bacteriostatic tooth protective toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, silicon dioxide of 100 mesh
13rd, pteria martensii shell powder 16, dicalcium phosphate dehydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carrageenan
0.3rd, xanthan gum 0.4, C12 alkyl polyglucoside 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, mountain bluish red element 3, Yuan
Sui quintessence oils 1.1, lycopene 1.3, active components A 12, active component B 17, active component C 8；The active component A is
Hopea chinensis crude extract；Active component C is Musca domestica larvae.
Further, the preparation method of the active component A is：Its is biological for holding for the hopea chinensis vegetable material of collection
Learn growth vigor and prune waste material gained, the vegetable material of collection is placed at room ventilation and is dried in the shade, then in 50 DEG C of constant temperature air blast
Fully it is dried in drying baker, is crushed with plant pulverizer, with the screen filtration of 150 mesh, collects the ultra-micro powder after sieving, it is standby
With；Aqueous two-phase extraction solvent, solid-liquid ratio 1: 40g/ are prepared by 60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate
ML prepares aqueous two-phase extraction solvent, and 30 min are soaked at 60 DEG C, and 50min is then extracted under ultrasonic extraction instrument, and condition is change
Width bar 6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and is removed solid
Body precipitates slag, and filtrate is placed in into concentrating under reduced pressure in Multi-example Parallel evaporator, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 12% Radix Scutellariae, 26% Herba Euphorbiae Humifusae, 18% old
Stork grass, 14% Radix Sanguisorbae, 30% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Musca domestica larva is taken, with distilled water flushing 3 times, Ran Houyong
Filter paper dips in dry polypide, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is extracted according to polypide quality and extracting liquid volume ratio
Liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) is worm
Body is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min High speed refrigerated centrifuges
Supernatant is collected after middle centrifugation 30min, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in into 100 DEG C of perseverances
Heated and stirred 5min in warm water bath, then treats its cooling 10min, then Aspirate supernatant is in 4800r/min high speed frozen centrifugations
30min is centrifuged in machine, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators,
As active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Embodiment 5
A kind of bacteriostatic tooth protective toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, silicon dioxide of 100 mesh
13rd, pteria martensii shell powder 16, dicalcium phosphate dehydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carrageenan
0.3rd, xanthan gum 0.4, C12 alkyl polyglucoside 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, mountain bluish red element 3, Yuan
Sui quintessence oils 1.1, lycopene 1.3, active components A 16, active component B 14, active component C 10；The active component A
For hopea chinensis crude extract；Active component C is Musca domestica larvae.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from Japanese red autumnal leaves Radix Berberidis Amurensis.
Further, the particle diameter of the pteria martensii conch meal powder is 105 mesh.
Further, the preparation method of the active component A is：Its is biological for holding for the hopea chinensis vegetable material of collection
Learn growth vigor and prune waste material gained, the vegetable material of collection is placed at room ventilation and is dried in the shade, then in 50 DEG C of constant temperature air blast
Fully it is dried in drying baker, is crushed with plant pulverizer, with the screen filtration of 150 mesh, collects the ultra-micro powder after sieving, it is standby
With；Aqueous two-phase extraction solvent, solid-liquid ratio 1: 40g/ are prepared by 60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate
ML prepares aqueous two-phase extraction solvent, and 30 min are soaked at 60 DEG C, and 50min is then extracted under ultrasonic extraction instrument, and condition is change
Width bar 6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and is removed solid
Body precipitates slag, and filtrate is placed in into concentrating under reduced pressure in Multi-example Parallel evaporator, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 12% Radix Scutellariae, 26% Herba Euphorbiae Humifusae, 18% old
Stork grass, 14% Radix Sanguisorbae, 30% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Musca domestica larva is taken, with distilled water flushing 3 times, Ran Houyong
Filter paper dips in dry polypide, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is extracted according to polypide quality and extracting liquid volume ratio
Liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) is worm
Body is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min High speed refrigerated centrifuges
Supernatant is collected after middle centrifugation 30min, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in into 100 DEG C of perseverances
Heated and stirred 5min in warm water bath, then treats its cooling 10min, then Aspirate supernatant is in 4800r/min high speed frozen centrifugations
30min is centrifuged in machine, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators,
As active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Comparative example 1
A kind of bacteriostatic tooth protective toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, silicon dioxide of 100 mesh
13rd, pteria martensii shell powder 16, dicalcium phosphate dehydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carrageenan
0.3rd, xanthan gum 0.4, C12 alkyl polyglucoside 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, mountain bluish red element 3, Yuan
Sui quintessence oils 1.1, lycopene 1.3, active component B 16, active component C 9；Active component C is Musca domestica larva antibacterial
Peptide.
Further, the preparation method of active component B is：In mass ratio by 12% Radix Scutellariae, 26% Herba Euphorbiae Humifusae, 18% old
Stork grass, 14% Radix Sanguisorbae, 30% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Musca domestica larva is taken, with distilled water flushing 3 times, Ran Houyong
Filter paper dips in dry polypide, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is extracted according to polypide quality and extracting liquid volume ratio
Liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) is worm
Body is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min High speed refrigerated centrifuges
Supernatant is collected after middle centrifugation 30min, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in into 100 DEG C of perseverances
Heated and stirred 5min in warm water bath, then treats its cooling 10min, then Aspirate supernatant is in 4800r/min high speed frozen centrifugations
30min is centrifuged in machine, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators,
As active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Comparative example 2
A kind of bacteriostatic tooth protective toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, silicon dioxide of 100 mesh
13rd, pteria martensii shell powder 16, dicalcium phosphate dehydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carrageenan
0.3rd, xanthan gum 0.4, C12 alkyl polyglucoside 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, mountain bluish red element 3, Yuan
Sui quintessence oils 1.1, lycopene 1.3, active components A 13, active component C 9；The active component A is slightly carried for hopea chinensis
Thing；Active component C is Musca domestica larvae.
Further, the preparation method of the active component A is：Its is biological for holding for the hopea chinensis vegetable material of collection
Learn growth vigor and prune waste material gained, the vegetable material of collection is placed at room ventilation and is dried in the shade, then in 50 DEG C of constant temperature air blast
Fully it is dried in drying baker, is crushed with plant pulverizer, with the screen filtration of 150 mesh, collects the ultra-micro powder after sieving, it is standby
With；Aqueous two-phase extraction solvent, solid-liquid ratio 1: 40g/ are prepared by 60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate
ML prepares aqueous two-phase extraction solvent, and 30 min are soaked at 60 DEG C, and 50min is then extracted under ultrasonic extraction instrument, and condition is change
Width bar 6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing is filtered, and is removed solid
Body precipitates slag, and filtrate is placed in into concentrating under reduced pressure in Multi-example Parallel evaporator, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component C is：Musca domestica larva is taken, with distilled water flushing 3 times, Ran Houyong
Filter paper dips in dry polypide, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is extracted according to polypide quality and extracting liquid volume ratio
Liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) is worm
Body is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min High speed refrigerated centrifuges
Supernatant is collected after middle centrifugation 30min, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in into 100 DEG C of perseverances
Heated and stirred 5min in warm water bath, then treats its cooling 10min, then Aspirate supernatant is in 4800r/min high speed frozen centrifugations
30min is centrifuged in machine, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators,
As active component C.
Test example
Using embodiment 1-5 and the toothpaste of comparative example 1-2 component preparation as test group, its fungistatic effect is tested.
1. oxford cup ethods
In each 1ml of Deca bacterium solution 0. of the MH agar plate surfaces of diameter 90mm, even spread.With tweezers with sterile working's skill
Art by the Oxford cuvette after sterilizing be gently put into it is above-mentioned be coated with the MH agar plates of antibacterial, it is uniform on each flat board
Four Oxford cuvettes of placement.0.5g embodiments 1-5 and comparative example 1-2 component are taken, in being added slowly to Oxford cuvette, each
The test component of same dose is added in three Oxford cuvettes on flat board, in a remaining Oxford cuvette 0.5mL is added
Normal saline does blank, carries out labelling, and above-mentioned flat board is lain against into 37 DEG C of constant incubator culture 16-18h (white vacation silks
Yeast culture 48h) result is observed afterwards.Inhibition zone is whether there is around observation cuvette, and measures its size.Every kind of antibacterial is cooked 3
Repeat, the meansigma methodss with antibacterial circle diameter are as result of the test.
2. agar dilution
1. the preparation of pastille agar, takes the component of 0.2g embodiments 2 and is added in the flat board of a diameter of 90mm, then takes after thawing
The MH agar 1.8ml that 0. more than 5h is balanced in 50 DEG C of water-baths add (medicine in flat board:Agar=1:9), side edged
Flat board is rocked, medicine and culture medium is fully mixed.
2. inoculation micro sample adding appliance takes the defined area that 2 μ l bacterium solutions are inoculated into flat board, makes the bacterium solution formed after inoculation
Loop diameter about 5-8mm.First it is inoculated with during inoculation containing the low flat board of concentration, inoculates containing the high flat board of concentration, is finally inoculated with not
The growth control flat board of drug containing, to check whole process of the test in test bacterium existing state.
3. cultivate mobile flat board after vaccination bacterium solution is done, put 37 DEG C of culture 16-20h (candida albicans bacterium cultivates 48h)
。
4. result judges that with the lowest concentration of drug on the MH agar plates for occurring without bacterium colony be the medicine to detecting bacterium most
Low Mlc (MIC), single colony growth is negligible.
3. physical and chemical index detection
Each component formula of embodiment 1-5 is investigated by GB8372 toothpaste standards, and add examined denseness and foaming figureofmerit,
Synthesis result see the table below, and from result, each formula mastic meets the requirement of GB8372 toothpaste standard.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and do not carrying on the back
In the case of the spirit or essential attributes of the present invention, the present invention can be in other specific forms realized.Therefore, no matter from which
From the point of view of a bit, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention will by appended right
Ask rather than described above is limited, it is intended that all changes that will fall in the implication and scope of the equivalency of claim
Include in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of description is only that for clarity those skilled in the art should
Using description as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.The ins and outs not described in detail in the present invention, can pass through arbitrary in this area
Prior art is realized.Particularly, all technical characterstics not described in detail can be realized by any prior art in the present invention.
Claims (6)
1. a kind of bacteriostatic tooth protective toothpaste, it is characterised in that be made up of following parts by weight meter raw material：Particle diameter is the hydration of 100 mesh
Silicon stone 6-9, silica 1 1-15, pteria martensii shell powder 13-21, dicalcium phosphate dehydrate 8-14, hydroxymethyl fiber
Plain sodium 5-9, xylitol 23-37 parts, carrageenan 0.1-0.5, xanthan gum 0.2-0.7, C12 alkyl polyglucoside 2-5, cocos nucifera oil acyl
CAB 0.3-0.9, flower color glycosides 2-4, mountain bluish red element 2-4, coriander quintessence oil 0.9-1.3, lycopene 1-2,
Active components A 11-17, active component B 13-19, active component C 7-11；The active component A is hopea chinensis crude extract；
Active component C is Musca domestica larvae.
2. bacteriostatic tooth protective toothpaste according to claim 1, it is characterised in that the grain of the pteria martensii conch meal powder
Footpath is 80-120 mesh.
3. bacteriostatic tooth protective toothpaste according to claim 1, it is characterised in that the preparation method of the active component A
For：The hopea chinensis vegetable material of collection prunes waste material gained, the vegetable material that will be gathered to keep its biological growth advantage
It is placed at room ventilation and dries in the shade, then be fully dried in 50 DEG C of constant temperature blast drying oven, crushed with plant pulverizer, uses 150
Purpose screen filtration, collects the ultra-micro powder after sieving, standby；By 60% (volume fraction) ethanol+10% (volume fraction) acetic acid
Ethyl ester prepares aqueous two-phase extraction solvent, and solid-liquid ratio 1: 40g/mL prepares aqueous two-phase extraction solvent, 30 min are soaked at 60 DEG C,
Then 50min is extracted under ultrasonic extraction instrument, condition is horn 6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s,
Have a rest 5s, centrifuging and taking supernatant after extraction, and Jing is filtered, and removes solid precipitation slag, and filtrate is placed in Multi-example Parallel evaporator
Concentrating under reduced pressure, obtains thick extracted extract, and 4 DEG C save backup.
4. bacteriostatic tooth protective toothpaste according to claim 1, it is characterised in that the preparation method of active component B
For：In mass ratio by 12% Radix Scutellariae, 26% Herba Euphorbiae Humifusae, 18% Herba Erodii, 14% Radix Sanguisorbae, 30% deionized water, decoct 2 times, merge and decoct
Liquid, filtered through gauze, filtrate heating is concentrated into 2g/mL containing crude drug, 100 DEG C of sterilizing 10min, and 4 DEG C save backup.
5. bacteriostatic tooth protective toothpaste according to claim 1, it is characterised in that the preparation method of active component C
For：Musca domestica larva is taken, with distilled water flushing 3 times, then dry polypide is dipped in filter paper, then is sterilized with 75% alcohol wipe polypide;Press
According to polypide quality and extracting liquid volume ratio be 1: 3 add extracting solution (0.05 mol/L ammonium acetate buffers, pH=5.0,
0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) polypide is placed in high-speed tissue mashing machine and is fully smashed to pieces, collect even
Serosity;Homogenate is centrifuged in 9000r/min High speed refrigerated centrifuges and collect supernatant, repeat the above steps 3 after 30min
It is secondary, supernatant is then combined with, supernatant is placed in into heated and stirred 5min in 100 DEG C of thermostat water baths, then treat its cooling
10min, then Aspirate supernatant is centrifuged 30min in 4800r/min High speed refrigerated centrifuges, finally takes centrifuge tube supernatant (anti-
Bacterium peptide crude extract) it is placed in small test tube and is stored in -20 DEG C of refrigerators, as active component C.
6. bacteriostatic tooth protective toothpaste according to claim 1, it is characterised in that all food stage of the raw material components or
Pharmaceutical grade.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611109935.9A CN106580769A (en) | 2016-12-06 | 2016-12-06 | Bacteriostatic and tooth-protecting toothpaste |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611109935.9A CN106580769A (en) | 2016-12-06 | 2016-12-06 | Bacteriostatic and tooth-protecting toothpaste |
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| Publication Number | Publication Date |
|---|---|
| CN106580769A true CN106580769A (en) | 2017-04-26 |
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ID=58596573
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233228A (en) * | 2017-07-20 | 2017-10-10 | 杭州坦珮信息技术有限公司 | A kind of manufacture method of anti-halitosis and carious tooth toothpaste |
| CN113717267A (en) * | 2021-09-02 | 2021-11-30 | 湖南师范大学 | Antibacterial peptide pHTP-1, application thereof and product containing antibacterial peptide pHTP-1 |
| CN114732763A (en) * | 2022-03-08 | 2022-07-12 | 普万特科技(南京)有限公司 | Oral cavity antibacterial liquid and preparation method thereof |
-
2016
- 2016-12-06 CN CN201611109935.9A patent/CN106580769A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233228A (en) * | 2017-07-20 | 2017-10-10 | 杭州坦珮信息技术有限公司 | A kind of manufacture method of anti-halitosis and carious tooth toothpaste |
| CN113717267A (en) * | 2021-09-02 | 2021-11-30 | 湖南师范大学 | Antibacterial peptide pHTP-1, application thereof and product containing antibacterial peptide pHTP-1 |
| CN114732763A (en) * | 2022-03-08 | 2022-07-12 | 普万特科技(南京)有限公司 | Oral cavity antibacterial liquid and preparation method thereof |
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