CN107233228A - A kind of manufacture method of anti-halitosis and carious tooth toothpaste - Google Patents
A kind of manufacture method of anti-halitosis and carious tooth toothpaste Download PDFInfo
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- CN107233228A CN107233228A CN201710594329.9A CN201710594329A CN107233228A CN 107233228 A CN107233228 A CN 107233228A CN 201710594329 A CN201710594329 A CN 201710594329A CN 107233228 A CN107233228 A CN 107233228A
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- Prior art keywords
- toothpaste
- antibacterial polypeptide
- halitosis
- carious tooth
- raw material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to the manufacture method of a kind of anti-halitosis and carious tooth toothpaste, it is characterised in that comprises the following steps：（1）, antibacterial polypeptide raw material preparation and the preparation of raw material of toothpaste,（2）, add antibacterial polypeptide raw material in lotion manufacturing step in toothpaste making process, antibacterial polypeptide composition is added in toothpaste.The preparation of the antibacterial polypeptide includes content the antibacterial polypeptide condensing crystallizing powder dissolved in purified water between 80 100%, is diluted to concentration for 0.001 5% antibacterial polypeptide solution.The toothpaste making process is followed successively by lotion and manufactures, examines, depositing cream, product inspection, packaging, outer packing, storage.The technology of the present invention is simple, effect is obvious.The new consumption view of toothpaste consumer is led with brand-new tooth paste product：Using toothpaste is pre- anti-halitosis and carious tooth.
Description
Technical field
The present invention relates to the manufacture method of a kind of anti-halitosis and carious tooth toothpaste and its obtained anti-halitosis and carious tooth toothpaste.
Background technology
Antibacterial polypeptide be it is a kind of can be with antibacterial, antiviral and fungi micromolecule polypeptide.Research shows, antibacterial polypeptide it is anti-
Bacterium spectrum is wide, it is strong to kill the effect of microorganism, and effect is special in terms of bacterial translocation, preventing and treating infection is suppressed, and it has antibacterium, mould
The various actives such as bacterium, virus, protozoon, cancer cell, conveyor screw.In addition to antibacterial activity, many antibacterial polypeptides are also antitumor, promote
Enter other bioactivity such as wound healing and protection sperm.
Halitosis is very awkward thing for the people of a normal work.Many people are perplexed by halitosis and occur social barrier
Hinder.Because there is halitosis, others keeps at a distance with him, and this reaction makes their stress very big.
Halitosis is a kind of multifactor the problem of cause, studies have shown that the pathogenic factor of most of halitosis is in oral cavity, it is small
The main cause of part halitosis causes in stomach tract disease.The influence factor of halitosis such as mouth disease：With carious tooth, gingivitis,
Easy breed bacteria, especially detests in the people of the mouth disease such as periodontitis, portacaval mucositis and decayed tooth, periodontosis, its oral cavity
Oxygen bacterium, its decomposition has produced sulfide, sends the taste of corruption, and produces halitosis.Enterogastric diseases, such as peptic ulcer,
Chronic gastritis, functional dyspepsia FD etc., all may be with halitosis.The reason for maiden's halitosis：Some are in adolescence
Women, hypoovarianism, when sex hormone level is relatively low, oral cavity tissue resistance declines, and easy bacteria infection is so as to produce mouth
It is smelly.Helicobacter pylori infections can also cause halitosis.Helicobacter pylori is after human body is entered, in order to resist hydrochloric acid in gastric juice killing action, meeting
Ammonia is produced by urea enzyme hydrolysis urea, ammonia cloud is formed around thalline protective layer is produced to oneself.And ammonia is foul odour
Gas.Therefore, the infection of helicobacter pylori is a major reason for causing halitosis.
Carious tooth is also known as decayed tooth, is the disease that bacterium triggers.It is able to can be caused when serious with secondary pulpitis and periapical inflammation
Alveolar bone and inflammation of jaws.Cavity is formed as treatment can allow lesion to continue development not in time, corona is destroyed disappearance completely,
Need to pull out tooth.
Bacterium is the basic reason that carious tooth occurs.It is generally acknowledged that the bacterium of cariogenic tooth has two major classes, a class is for example to deform
The effect of the bacteriums such as streptococcus, actinomyces and lactobacillus makes carbohydrate breakdown produce acid, causes tooth progressively to be corroded
Destruction；The organic matter of the another kind of action breaks down tooth for being gram-positive cocci, can make tooth formation dental caries by invading corruption for a long time
Hole.Generation of the growth of porphyromonas gingivalis also with periodontitis is closely related.Due to the corrosion of bacterium incessantly to tooth
Injury, results in halitosis and carious tooth.
The characteristics of halitosis and carious tooth is that the incidence of disease is high, and distribution is wide.Especially carious tooth is the main common disease in oral cavity, is also the mankind
Itself and tumour and angiocardiopathy are listed as the big keypoint control disease of the mankind three by one of most common disease, the World Health Organization
Disease.
Also there is the toothpaste patent of some pre- anti-caries the country：
Such as Chinese herbal toothpaste：
A kind of Chinese herbal toothpaste of Patent No. 201110088869.2, is the Chinese herbal toothpaste based on folium artemisiae argyi, and it both had
The effect of tooth is cleaned, and there is good anti-inflammation, hemostasis and pain-relieving effect simultaneously.
One group based on grass-leaved sweetflag of applicant Li Lifen Patent No. CN201510406687.3 Chinese herbal toothpaste
Raw material, function and usage is similar with former.
The toothpaste of Patent No. 201510067326.0 is one assembling for bioactivity hyaluronic acid and D-sorbite composition
Side, solves mouth disease prevention.
These toothpaste are not to use antibacterial polypeptide anti-caries.
The lysozyme toothpaste that recent domestic market is risen, only describes the patent of invention using Fudan University, does not find
Direct patent.
It is domestic also without the patent of pre- anti-halitosis toothpaste can be alleviated.
The content of the invention
Present invention solves the technical problem that being to provide a kind of manufacture method alleviated with pre- anti-halitosis and carious tooth toothpaste, make pre-
Anti-halitosis and carious tooth technology tends to be perfect, adds than extracting type, chemical synthesis type antibacterial using plant and Chinese herbal medicine
Plus the pre- anti-halitosis and carious tooth tooth paste product technology of agent exploitation is simple, effect is obvious.Toothpaste is led to disappear with brand-new tooth paste product
The new consumption view of the person of expense：Using toothpaste is pre- anti-halitosis and carious tooth.
Intraoral bacterium can cause halitosis and decayed tooth, and real arch-criminal is to have chewed to remain in dental surface after food
Harmful bacteria, these harmful bacterias are in the environment of oral cavity warm and moist, in the eutrophic environment of food residual, make carbon aquation
Compound decomposes a kind of acidic materials eroding dental enamel of release, causes halitosis and carious tooth.Effect plus gram-positive cocci is broken
The organic matter of bad dental surface.Halitosis and carious tooth occur for these harm, and cavity is produced, injury of teeth.
If in toothpaste addition can kill bacterium again will not do harm to huamn body antibacterial polypeptide, what is brushed teeth
During by enter oral cavity bacterium kill substantially, health will not be caused harm again, people correctly brush teeth and used
Antiseptic toothpaste, it is not necessary to which worry is because halitosis and carious tooth occur for mouth disease
The people that the purpose of the present invention is to aid in oral health issue uses pre- anti-halitosis and carious tooth the hardship of toothpaste.
Meaning toothpaste of the invention is：Toothpaste and other lotion class dental health products.
The present invention solves the technical scheme that is used of above-mentioned technical problem：A kind of manufacturer of anti-halitosis and carious tooth toothpaste
Method, its technological process of production is as follows：
（1）, antibacterial polypeptide raw material preparation and the preparation of raw material of toothpaste,
（2）, in toothpaste making process add antibacterial polypeptide raw material, antibacterial polypeptide composition is added in toothpaste.Institute of the present invention
State antibacterial polypeptide preparation include by content between 80-100% antibacterial polypeptide condensing crystallizing powder dissolved in purified water, dilution
It is 0.001-5% solution for standby to concentration；The toothpaste making process for be followed successively by lotion manufacture, examine, deposit cream, product inspection,
Packaging, outer packing, storage step, and antibacterial polypeptide dilute solution is added in lotion manufacturing step, make antibacterial polypeptide composition
Inside the raw material for being evenly distributed in toothpaste.
The present invention manufactures the application in field with the excellent broad spectrum antibacterial performance of antibacterial polypeptide in toothpaste, make it is pre- anti-halitosis and
The technology of carious tooth tends to be perfect, is developed with extracting type, chemical synthesis type antibacterial additives using plant and Chinese herbal medicine
It is pre- it is anti-halitosis compared with the toothpaste of carious tooth, technology is simple, effect is obvious, and can change the situation of halitosis and carious tooth.With brand-new
Tooth paste product lead the new consumption view of toothpaste consumer：Brush teeth pre- anti-halitosis and carious tooth.
Brief description of the drawings
Fig. 1 is the process chart of the embodiment of the present invention.
Embodiment
Antibacterial polypeptide solution of the present invention is to common oral anaerobic bacteria：The resistance of porphyromonas gingivalis and Streptococcus mutans is surveyed
Determine result as follows：
Note：1. porphyromonas gingivalis is standard strain ATCC33277；
2. Streptococcus mutans are standard strain ATCC25175；
3. experiment by microbiological analysis inspection center of Guangdong Province according to《Disinfection technology standard》2002 editions -2.1.11.3.1 are performed.
The process chart of the embodiment of the present invention is referring to Fig. 1, and three embodiments differ only in raw material of toothpaste according to each
Self application people's constitution and characteristics of demand carry out selection proportioning.
Embodiment 1：
A kind of anti-halitosis and carious tooth children's toothpaste technological process of production for protecting teenager teeth is as follows：
（1）, antibacterial polypeptide raw material preparation and the preparation of raw material of toothpaste,
（2）, in toothpaste making process add antibacterial polypeptide raw material, antibacterial polypeptide composition is added in toothpaste.Institute of the present invention
State antibacterial polypeptide preparation include by content between 80-100% antibacterial polypeptide condensing crystallizing powder dissolved in purified water, dilution
It is 0.0005-2% solution for standby to concentration；The raw material of toothpaste includes rubbing agent, clean-preserving agent, thickener, foaming agent, flavouring agent
With other small powders, production process is to be followed successively by cream processed（Lotion is manufactured）, examine, deposit cream, product inspection, packaging, outer packing, storage
Step, and antibacterial polypeptide dilute solution is added in lotion manufacturing step, antibacterial polypeptide composition is evenly distributed in toothpaste
Raw material inside.
The present invention manufactures the application in field with the excellent broad spectrum antibacterial performance of antibacterial polypeptide in toothpaste, make it is pre- anti-halitosis and
The technology of carious tooth tends to be perfect, is developed with extracting type, chemical synthesis type antibacterial additives using plant and Chinese herbal medicine
It is pre- it is anti-halitosis compared with the toothpaste of carious tooth, technology is simple, effect is obvious, and can change the situation of halitosis and carious tooth.With brand-new
Tooth paste product lead the new consumption view of toothpaste consumer：Brush teeth pre- anti-halitosis and carious tooth.
Embodiment 2：
A kind of its technological process of production of person in middle and old age's toothpaste is as follows：
（1）, antibacterial polypeptide raw material preparation and the preparation of raw material of toothpaste,
（2）, in toothpaste making process add antibacterial polypeptide raw material, antibacterial polypeptide composition is added in toothpaste.Institute of the present invention
State antibacterial polypeptide preparation include by content between 80-100% antibacterial polypeptide condensing crystallizing powder dissolved in purified water, dilution
It is 0.001-3% solution for standby to concentration；The toothpaste making process is followed successively by lotion and manufactures, examines, depositing cream, product inspection, bag
Dress, outer packing, storage step, and antibacterial polypeptide dilute solution is added in cream step processed, make antibacterial polypeptide composition equably
Inside the raw material for being distributed in toothpaste.
The present invention manufactures the application in field with the excellent broad spectrum antibacterial performance of antibacterial polypeptide in toothpaste, make it is pre- anti-halitosis and
The technology of carious tooth tends to be perfect, is developed with extracting type, chemical synthesis type antibacterial additives using plant and Chinese herbal medicine
It is pre- it is anti-halitosis compared with the toothpaste of carious tooth, technology is simple, effect is obvious, and can change the situation of halitosis and carious tooth.With brand-new
Tooth paste product lead the new consumption view of toothpaste consumer：Brush teeth pre- anti-halitosis and carious tooth.
Embodiment 3：
A kind of pre- anti-halitosis and its technological process of production of the toothpaste of carious tooth is as follows：
（1）, antibacterial polypeptide raw material preparation and the preparation of raw material of toothpaste,
（2）, in toothpaste making process add antibacterial polypeptide raw material, antibacterial polypeptide composition is added in toothpaste.Institute of the present invention
State antibacterial polypeptide preparation include by content between 80-100% antibacterial polypeptide condensing crystallizing powder dissolved in purified water, dilution
It is 0.0015-5% solution for standby to concentration；The toothpaste making process is manufactured, examined to be followed successively by lotion, depositing cream, into product examine
Test, pack, outer packing, storage step, and antibacterial polypeptide dilute solution is added in cream step processed, makes antibacterial polypeptide composition equal
Inside the raw material for being distributed in toothpaste evenly.
The present invention manufactures the application in field with the excellent broad spectrum antibacterial performance of antibacterial polypeptide in toothpaste, make it is pre- anti-halitosis and
The technology of carious tooth tends to be perfect, is developed with extracting type, chemical synthesis type antibacterial additives using plant and Chinese herbal medicine
It is pre- it is anti-halitosis compared with the toothpaste of carious tooth, technology is simple, effect is obvious, and can change the situation of halitosis and carious tooth.With brand-new
Tooth paste product lead the new consumption view of toothpaste consumer：Brush teeth pre- anti-halitosis and carious tooth.
Claims (3)
1. the manufacture method of a kind of anti-halitosis and carious tooth toothpaste, it is characterised in that comprise the following steps：
（1）, antibacterial polypeptide raw material preparation and the preparation of raw material of toothpaste,
（2）, add antibacterial polypeptide raw material in lotion manufacturing step in toothpaste making process, be added to antibacterial polypeptide composition
In toothpaste.
2. the manufacture method of anti-halitosis according to claim 1 and carious tooth toothpaste, it is characterised in that：The standard of the antibacterial polypeptide
It is standby to include content the antibacterial polypeptide condensing crystallizing powder dissolved in purified water between 80-100%, concentration is diluted to for 0.001-
5% antibacterial polypeptide solution.
3. the manufacture method of anti-halitosis according to claim 2 and carious tooth toothpaste, it is characterised in that：The toothpaste making process
It is followed successively by lotion manufacture, examine, depositing cream, product inspection, packaging, outer packing, storage, antibacterial polypeptide solution is in lotion manufacturing step
Addition.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710594329.9A CN107233228A (en) | 2017-07-20 | 2017-07-20 | A kind of manufacture method of anti-halitosis and carious tooth toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710594329.9A CN107233228A (en) | 2017-07-20 | 2017-07-20 | A kind of manufacture method of anti-halitosis and carious tooth toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107233228A true CN107233228A (en) | 2017-10-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710594329.9A Pending CN107233228A (en) | 2017-07-20 | 2017-07-20 | A kind of manufacture method of anti-halitosis and carious tooth toothpaste |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1922203A (en) * | 2004-01-19 | 2007-02-28 | 卢卡斯·海布雷赫特 | Anticariogenic proteins and peptides and saccharides |
| CN103468673A (en) * | 2013-06-19 | 2013-12-25 | 江苏吉锐生物技术有限公司 | Preparation method and applications of antibacterial peptide |
| CN105153285A (en) * | 2015-09-17 | 2015-12-16 | 北京化工大学 | Antibacterial peptide |
| CN105767419A (en) * | 2016-04-06 | 2016-07-20 | 俞祖勋 | Production method of caries-prevention candies |
| CN106580771A (en) * | 2016-12-06 | 2017-04-26 | 广东康绿宝科技实业有限公司 | Children's toothpaste |
| CN106580769A (en) * | 2016-12-06 | 2017-04-26 | 广东康绿宝科技实业有限公司 | Bacteriostatic and tooth-protecting toothpaste |
| CN106580849A (en) * | 2016-12-06 | 2017-04-26 | 广东康绿宝科技实业有限公司 | Natural plant component toothpaste |
-
2017
- 2017-07-20 CN CN201710594329.9A patent/CN107233228A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1922203A (en) * | 2004-01-19 | 2007-02-28 | 卢卡斯·海布雷赫特 | Anticariogenic proteins and peptides and saccharides |
| CN103468673A (en) * | 2013-06-19 | 2013-12-25 | 江苏吉锐生物技术有限公司 | Preparation method and applications of antibacterial peptide |
| CN105153285A (en) * | 2015-09-17 | 2015-12-16 | 北京化工大学 | Antibacterial peptide |
| CN105767419A (en) * | 2016-04-06 | 2016-07-20 | 俞祖勋 | Production method of caries-prevention candies |
| CN106580771A (en) * | 2016-12-06 | 2017-04-26 | 广东康绿宝科技实业有限公司 | Children's toothpaste |
| CN106580769A (en) * | 2016-12-06 | 2017-04-26 | 广东康绿宝科技实业有限公司 | Bacteriostatic and tooth-protecting toothpaste |
| CN106580849A (en) * | 2016-12-06 | 2017-04-26 | 广东康绿宝科技实业有限公司 | Natural plant component toothpaste |
Non-Patent Citations (1)
| Title |
|---|
| 杨九闻: "《日用工业品商品学》", 30 October 1983, 中央广播电视大学出版社 * |
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| SE01 | Entry into force of request for substantive examination | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20171010 |
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| RJ01 | Rejection of invention patent application after publication |