CN106580771A - Children's toothpaste - Google Patents
Children's toothpaste Download PDFInfo
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- CN106580771A CN106580771A CN201611111674.4A CN201611111674A CN106580771A CN 106580771 A CN106580771 A CN 106580771A CN 201611111674 A CN201611111674 A CN 201611111674A CN 106580771 A CN106580771 A CN 106580771A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention provides children's toothpaste. The toothpaste is small in irritation on mucous membrane and capable of effectively protecting children's teeth, is safe and harmless if children eat the toothpaste by mistake, has special color and faint scent and is capable of arousing appetite of tooth brushing of children and beneficial for children's tooth growth and oral health.
Description
Technical field
The invention belongs to daily-use chemical industry product technical field, and in particular to a kind of children's toothpaste.
Background technology
This colony of children represents the following of country and wishes, their physical and mental health and growth enjoy each family and
The concern of the whole society.As a rule, children refer to the colony of 3-12 year.The colony of 3-6 year age bracket is preschool child;
The colony of 6-12 year age bracket is school-ager.Preschool child's self care ability is poor, relies primarily on the head of a family and child is old
Teacher guides and helps;School-ager starts to accept the education, and big colony's sexuality increases, and existence general knowledge and self care ability have
Certain raising, but the guidance of the head of a family and teacher is still needed to, they are declared with the using method for passing through oral care knowledge and oral-cavity article
It is very important.
Oral health care of children affects very big to its physically and mentally healthy and later growth, and toothpaste is oral health care product
Most important one in race, suitable Pediatric Oral Emergency physilogical characteristics and the toothpaste using feature at heart how are developed, use for reference flourishing state
The newest research results of family's children's toothpaste, are that research staff must the comprehensive important topic thought deeply.
Pediatric Oral Emergency main feature can summarize the following aspects:
1. mucous membrane of mouth opposing environmental stimuli power is poor, subject to damage.
2. tooth is delicate easily receives pressure injury.
3. decayed tooth is also easy to produce, if controlling bad, hidden danger can be left.
4. oral health care product, toothpaste, toothbrush, mouthwash etc. are used, because its method is improper and sense of self-protection
Difference easily occurs to swallow and injure oral cavity tissue problem by mistake.
5. it is incorrect due to some bad eating habits and using oral health-care product method, to later dental growth and
Oral health has undesirable effect.
Oral cavity health care knowledge is passed through to children a surname, correct guiding uses oral health care product, exploitation to be adapted to the mouth of children's feature
Chamber articles for use, this will be the cause that the whole society pays close attention to jointly.Toothpaste research staff should explore newly in terms of the exploitation of children's toothpaste
Method.
The content of the invention
In view of this, the present invention provides a kind of children's toothpaste, and the toothpaste of the present invention is little to oral cavity irritation on mucous membrane, Neng Gouyou
Effect protection teenager teeth, it is safe and harmless after eating by mistake orally, with special color and delicate fragrance, the desire that children can be caused to brush teeth
Hope, be conducive to growth and the oral health of teenager teeth.
The technical scheme is that：A kind of children's toothpaste, is made up of following parts by weight meter raw material：Particle diameter is 100 mesh
Hydrated silica 6-9, silica 1 1-15, pteria martensii shell powder 13-21, dicalcium phosphate dihydrate 8-14, hydroxyl first
Base sodium cellulosate 5-9, xylitol 23-37 parts, carragheen 0.1-0.5, xanthans 0.2-0.7, C14 APG 2-5,
Cocounut oil acyl CAB 0.3-0.9, flower color glycosides 2-4, mountain indigo plant red pigment 2-4, kamuning essential oil 0.9-1.3, tea are more
Phenol 1-2, active components A 11-17, active component B 13-19, active component C 7-11；The active component A is Chinese toon tender shoots
Water extract；Active component B is yellow meal worm antibacterial peptide；Active component C is clever rhizome of chuanxiong mycoplasma.
Particularly, heretofore described flower color glycosides is sweet from red bayberry, purple sweetpotato, raspberry, multicolored flame nettle, purple
The natural anthocyanin that any one is extracted in indigo plant, blueberry, window box oxalis, Japanese red autumnal leaves barberry, vetch.
Further, the particle diameter of the pteria martensii oyster shell whiting powder is 80-120 mesh.
Further, the preparation method of the active component A is：To press after fresh Chinese toon tender shoots leaf belt cane chopping
Solid-liquid ratio 2（g）:3（mL）In adding distilled water, 8min is boiled, filtered, the soluble solid content being concentrated in water extract is
50-55%。
Further, the preparation method of active component B is：Yellow meal worm larva is taken, first polypide 3 is rinsed into running water
It is secondary, then with distilled water flushing 3 times, then dry polypide is dipped in filter paper, then sterilized with 75% alcohol wipe polypide;According to polypide quality
It is 1: 3 addition extract (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL benzene first with extracting liquid volume ratio
Base sulfuryl fluoride and 2 ‰ mercaptoethanols) polypide is placed in high-speed tissue mashing machine and is fully smashed to pieces, collect homogenate;By homogenate
It is centrifuged in 9000r/min high speed freezing centrifuges after 30min and collects supernatant, repeat the above steps 3 times is then combined with
Supernatant, by supernatant heating stirring 5min in 100 DEG C of thermostat water baths is placed in, and then treats its cooling 10min, then draws supernatant
Liquid is centrifuged 30min in 4800r/min high speed freezing centrifuges, finally take centrifuge tube supernatant (antibacterial peptide crude extract) be placed in it is little
During -20 DEG C of refrigerators are stored in test tube, as active component B.
Further, the preparation method of active component C is：Using Ligusticum wallichii as growth substrate, ganoderma lucidum mycelium is connect
Plant on matrix, by clever rhizome of chuanxiong mycoplasma obtained in two-way solid-fermented technique.
Further, all food-grades of the raw material components or pharmaceutical grade.
The beneficial effects of the present invention is：In the children's toothpaste of the present invention, using active skull cap components the essence of toothpaste, color are used as
Element and preservative, are acted on by the compound synergic of each component in the present invention, can be effectively accomplished killing oral cavity harmful thin
The effect of bacterium, at the same it is little to oral cavity irritation on mucous membrane, being capable of effective protection teenager teeth.By the effect of active component A, can
Become the natural antiseptic agent of toothpaste, coordinate the matched combined of flower color glycosides and mountain indigo plant red pigment, become reconciled from the physilogical characteristics of children
It is strange to increase degree of liking of the children to toothpaste at heart, excite using the enthusiasm and desire of toothpaste；The present invention selects excitant relative
Relatively low raw material design formulation of tooth-paste, the injury to Pediatric Oral Emergency is minimum；Rich in natural in active component B and active component C
Sterilized and nutrient content, acts on the cell membrane of bacterium in oral cavity, then destroys its integrality and produces perforation, thin so as to cause
The intracellular extracellular and dead or antibacterial peptide of tolerant spilling acts on memebrane protein and causes cohesion, inactivation and ion channel, causes film to permeate
Sexually revise and cause bacterial death, be a with mothproof and nutrition concept for treatment mouth disease has certain auxiliary curative effect
As the children's toothpaste of the main starting point of exploitation.
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with the embodiment of the present invention, it is clear that retouched
The embodiment stated is only a part of embodiment of the invention, rather than the embodiment of whole.Based on the embodiment in the present invention, this
The every other embodiment that field those of ordinary skill is obtained under the premise of creative work is not made, belongs to the present invention
The scope of protection.
Embodiment 1
A kind of children's toothpaste, is made up of following parts by weight meter raw material：Particle diameter be the hydrated silica 7 of 100 mesh, silica 13,
Pteria martensii shell powder 16, dicalcium phosphate dihydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carragheen
0.3rd, xanthans 0.4, C14 APGs 3, cocounut oil acyl CAB 0.4, flower color glycosides 3, mountain indigo plant red pigment 3, nine
In essential oil 1.1, Tea Polyphenols 1.3, active components A 13, active component B 16, active component C 9；The active component A is
Chinese toon tender shoots water extract；Active component B is yellow meal worm antibacterial peptide；Active component C is clever rhizome of chuanxiong mycoplasma.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from red bayberry.
Further, the particle diameter of the pteria martensii oyster shell whiting powder is 110 mesh.
Further, the preparation method of the active component A is：To press after fresh Chinese toon tender shoots leaf belt cane chopping
Solid-liquid ratio 2（g）:3（mL）In adding distilled water, 8min is boiled, filtered, the soluble solid content being concentrated in water extract is
50-55%。
Further, the preparation method of active component B is：Yellow meal worm larva is taken, first polypide 3 is rinsed into running water
It is secondary, then with distilled water flushing 3 times, then dry polypide is dipped in filter paper, then sterilized with 75% alcohol wipe polypide;According to polypide quality
It is 1: 3 addition extract (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL benzene first with extracting liquid volume ratio
Base sulfuryl fluoride and 2 ‰ mercaptoethanols) polypide is placed in high-speed tissue mashing machine and is fully smashed to pieces, collect homogenate;By homogenate
It is centrifuged in 9000r/min high speed freezing centrifuges after 30min and collects supernatant, repeat the above steps 3 times is then combined with
Supernatant, by supernatant heating stirring 5min in 100 DEG C of thermostat water baths is placed in, and then treats its cooling 10min, then draws supernatant
Liquid is centrifuged 30min in 4800r/min high speed freezing centrifuges, finally take centrifuge tube supernatant (antibacterial peptide crude extract) be placed in it is little
During -20 DEG C of refrigerators are stored in test tube, as active component B.
Further, the preparation method of active component C is：Using Ligusticum wallichii as growth substrate, ganoderma lucidum mycelium is connect
Plant on matrix, by clever rhizome of chuanxiong mycoplasma obtained in two-way solid-fermented technique.
Further, all food-grades of the raw material components or pharmaceutical grade.
Children's toothpaste of the present invention can adopt completely the conventional method of this area to prepare, such as《Detergent compositions workshop manual》
(Xu Baocai etc. writes, Chemical Industry Press, chemistry and applied chemistry publishing centre, January the 1st edition in 2006) the
Toothpaste making process disclosed in 594-597 page is prepared.Specifically, the preparation method of the present embodiment children's toothpaste is：Will
After above-mentioned raw materials component is weighed, dispersion, mixing in pre-dispersed kettle are driven cream kettle vavuum pump processed and suck above-mentioned liquid material, are then opened and are scraped
Knife, agitator and colloid mill, close successively colloid mill, agitator and scraper after 50 minutes, vacuum breaker obtains children's toothpaste.
Obviously, in the present invention the preparation method of toothpaste is prior art, not special character, and the present invention's mainly changes
Enter to be that the difference of formula.
Embodiment 2
A kind of children's toothpaste, is made up of following parts by weight meter raw material：Particle diameter be the hydrated silica 6 of 100 mesh, silica 11,
Pteria martensii shell powder 13, dicalcium phosphate dihydrate 8, hydroxy-methyl cellulose sodium 5,23 parts of xylitol, carragheen
0.1st, xanthans 0.2, C14 APGs 2, cocounut oil acyl CAB 0.3, flower color glycosides 2, mountain indigo plant red pigment 2, nine
In essential oil 0.9, Tea Polyphenols 1, active components A 11, active component B 13, active component C 7；The active component A is perfume
Chinese toon tender shoots water extract；Active component B is yellow meal worm antibacterial peptide；Active component C is clever rhizome of chuanxiong mycoplasma.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from purple sweetpotato.
Further, the particle diameter of the pteria martensii oyster shell whiting powder is 120 mesh.
Further, the preparation method of the active component A is：To press after fresh Chinese toon tender shoots leaf belt cane chopping
Solid-liquid ratio 2（g）:3（mL）In adding distilled water, 8min is boiled, filtered, the soluble solid content being concentrated in water extract is
50-55%。
Further, the preparation method of active component B is：Yellow meal worm larva is taken, first polypide 3 is rinsed into running water
It is secondary, then with distilled water flushing 3 times, then dry polypide is dipped in filter paper, then sterilized with 75% alcohol wipe polypide;According to polypide quality
It is 1: 3 addition extract (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL benzene first with extracting liquid volume ratio
Base sulfuryl fluoride and 2 ‰ mercaptoethanols) polypide is placed in high-speed tissue mashing machine and is fully smashed to pieces, collect homogenate;By homogenate
It is centrifuged in 9000r/min high speed freezing centrifuges after 30min and collects supernatant, repeat the above steps 3 times is then combined with
Supernatant, by supernatant heating stirring 5min in 100 DEG C of thermostat water baths is placed in, and then treats its cooling 10min, then draws supernatant
Liquid is centrifuged 30min in 4800r/min high speed freezing centrifuges, finally take centrifuge tube supernatant (antibacterial peptide crude extract) be placed in it is little
During -20 DEG C of refrigerators are stored in test tube, as active component B.
Further, the preparation method of active component C is：Using Ligusticum wallichii as growth substrate, ganoderma lucidum mycelium is connect
Plant on matrix, by clever rhizome of chuanxiong mycoplasma obtained in two-way solid-fermented technique.
Further, all food-grades of the raw material components or pharmaceutical grade.
Embodiment 3
A kind of children's toothpaste, is made up of following parts by weight meter raw material：Particle diameter be the hydrated silica 9 of 100 mesh, silica 15,
Pteria martensii shell powder 21, dicalcium phosphate dihydrate 14, hydroxy-methyl cellulose sodium 9,37 parts of xylitol, carragheen 0.5,
Xanthans 0.7, C14 APGs 5, cocounut oil acyl CAB 0.9, flower color glycosides 4, mountain indigo plant red pigment 4, murralongin
Oil 1.3, Tea Polyphenols 2, active components A 17, active component B 19, active component C 11；The active component A is that Chinese toon is tender
Bud water extract；Active component B is yellow meal worm antibacterial peptide；Active component C is clever rhizome of chuanxiong mycoplasma.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from violet cabbage.
Further, the particle diameter of the pteria martensii oyster shell whiting powder is 80 mesh.
Further, the preparation method of the active component A is：To press after fresh Chinese toon tender shoots leaf belt cane chopping
Solid-liquid ratio 2（g）:3（mL）In adding distilled water, 8min is boiled, filtered, the soluble solid content being concentrated in water extract is
50-55%。
Further, the preparation method of active component B is：Yellow meal worm larva is taken, first polypide 3 is rinsed into running water
It is secondary, then with distilled water flushing 3 times, then dry polypide is dipped in filter paper, then sterilized with 75% alcohol wipe polypide;According to polypide quality
It is 1: 3 addition extract (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL benzene first with extracting liquid volume ratio
Base sulfuryl fluoride and 2 ‰ mercaptoethanols) polypide is placed in high-speed tissue mashing machine and is fully smashed to pieces, collect homogenate;By homogenate
It is centrifuged in 9000r/min high speed freezing centrifuges after 30min and collects supernatant, repeat the above steps 3 times is then combined with
Supernatant, by supernatant heating stirring 5min in 100 DEG C of thermostat water baths is placed in, and then treats its cooling 10min, then draws supernatant
Liquid is centrifuged 30min in 4800r/min high speed freezing centrifuges, finally take centrifuge tube supernatant (antibacterial peptide crude extract) be placed in it is little
During -20 DEG C of refrigerators are stored in test tube, as active component B.
Further, the preparation method of active component C is：Using Ligusticum wallichii as growth substrate, ganoderma lucidum mycelium is connect
Plant on matrix, by clever rhizome of chuanxiong mycoplasma obtained in two-way solid-fermented technique.
Further, all food-grades of the raw material components or pharmaceutical grade.
Embodiment 4
A kind of children's toothpaste, is made up of following parts by weight meter raw material：Particle diameter be the hydrated silica 7 of 100 mesh, silica 13,
Pteria martensii shell powder 16, dicalcium phosphate dihydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carragheen
0.3rd, xanthans 0.4, C14 APGs 3, cocounut oil acyl CAB 0.4, flower color glycosides 3, mountain indigo plant red pigment 3, nine
In essential oil 1.1, Tea Polyphenols 1.3, active components A 12, active component B 17, active component C 8；The active component A is
Chinese toon tender shoots water extract；Active component B is yellow meal worm antibacterial peptide；Active component C is clever rhizome of chuanxiong mycoplasma.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from blueberry.
Further, the particle diameter of the pteria martensii oyster shell whiting powder is 90 mesh.
Further, the preparation method of the active component A is：To press after fresh Chinese toon tender shoots leaf belt cane chopping
Solid-liquid ratio 2（g）:3（mL）In adding distilled water, 8min is boiled, filtered, the soluble solid content being concentrated in water extract is
50-55%。
Further, the preparation method of active component B is：Yellow meal worm larva is taken, first polypide 3 is rinsed into running water
It is secondary, then with distilled water flushing 3 times, then dry polypide is dipped in filter paper, then sterilized with 75% alcohol wipe polypide;According to polypide quality
It is 1: 3 addition extract (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL benzene first with extracting liquid volume ratio
Base sulfuryl fluoride and 2 ‰ mercaptoethanols) polypide is placed in high-speed tissue mashing machine and is fully smashed to pieces, collect homogenate;By homogenate
It is centrifuged in 9000r/min high speed freezing centrifuges after 30min and collects supernatant, repeat the above steps 3 times is then combined with
Supernatant, by supernatant heating stirring 5min in 100 DEG C of thermostat water baths is placed in, and then treats its cooling 10min, then draws supernatant
Liquid is centrifuged 30min in 4800r/min high speed freezing centrifuges, finally take centrifuge tube supernatant (antibacterial peptide crude extract) be placed in it is little
During -20 DEG C of refrigerators are stored in test tube, as active component B.
Further, the preparation method of active component C is：Using Ligusticum wallichii as growth substrate, ganoderma lucidum mycelium is connect
Plant on matrix, by clever rhizome of chuanxiong mycoplasma obtained in two-way solid-fermented technique.
Further, all food-grades of the raw material components or pharmaceutical grade.
Embodiment 5
A kind of children's toothpaste, is made up of following parts by weight meter raw material：Particle diameter be the hydrated silica 7 of 100 mesh, silica 13,
Pteria martensii shell powder 16, dicalcium phosphate dihydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carragheen
0.3rd, xanthans 0.4, C14 APGs 3, cocounut oil acyl CAB 0.4, flower color glycosides 3, mountain indigo plant red pigment 3, nine
In essential oil 1.1, Tea Polyphenols 1.3, active components A 16, active component B 14, active component C 10；The active component A is
Chinese toon tender shoots water extract；Active component B is yellow meal worm antibacterial peptide；Active component C is clever rhizome of chuanxiong mycoplasma.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from Japanese red autumnal leaves barberry.
Further, the particle diameter of the pteria martensii oyster shell whiting powder is 105 mesh.
Further, the preparation method of the active component A is：To press after fresh Chinese toon tender shoots leaf belt cane chopping
Solid-liquid ratio 2（g）:3（mL）In adding distilled water, 8min is boiled, filtered, the soluble solid content being concentrated in water extract is
50-55%。
Further, the preparation method of active component B is：Yellow meal worm larva is taken, first polypide 3 is rinsed into running water
It is secondary, then with distilled water flushing 3 times, then dry polypide is dipped in filter paper, then sterilized with 75% alcohol wipe polypide;According to polypide quality
It is 1: 3 addition extract (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL benzene first with extracting liquid volume ratio
Base sulfuryl fluoride and 2 ‰ mercaptoethanols) polypide is placed in high-speed tissue mashing machine and is fully smashed to pieces, collect homogenate;By homogenate
It is centrifuged in 9000r/min high speed freezing centrifuges after 30min and collects supernatant, repeat the above steps 3 times is then combined with
Supernatant, by supernatant heating stirring 5min in 100 DEG C of thermostat water baths is placed in, and then treats its cooling 10min, then draws supernatant
Liquid is centrifuged 30min in 4800r/min high speed freezing centrifuges, finally take centrifuge tube supernatant (antibacterial peptide crude extract) be placed in it is little
During -20 DEG C of refrigerators are stored in test tube, as active component B.
Further, the preparation method of active component C is：Using Ligusticum wallichii as growth substrate, ganoderma lucidum mycelium is connect
Plant on matrix, by clever rhizome of chuanxiong mycoplasma obtained in two-way solid-fermented technique.
Further, all food-grades of the raw material components or pharmaceutical grade.
Comparative example 1
A kind of children's toothpaste, is made up of following parts by weight meter raw material：Particle diameter be the hydrated silica 7 of 100 mesh, silica 13,
Pteria martensii shell powder 16, dicalcium phosphate dihydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carragheen
0.3rd, xanthans 0.4, C14 APGs 3, cocounut oil acyl CAB 0.4, flower color glycosides 3, mountain indigo plant red pigment 3, nine
In essential oil 1.1, Tea Polyphenols 1.3, active component B 16, active component C 9；Active component B is yellow meal worm antibacterial peptide；
Active component C is clever rhizome of chuanxiong mycoplasma.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from red bayberry.
Further, the particle diameter of the pteria martensii oyster shell whiting powder is 110 mesh.
Further, the preparation method of active component B is：Yellow meal worm larva is taken, first polypide 3 is rinsed into running water
It is secondary, then with distilled water flushing 3 times, then dry polypide is dipped in filter paper, then sterilized with 75% alcohol wipe polypide;According to polypide quality
It is 1: 3 addition extract (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL benzene first with extracting liquid volume ratio
Base sulfuryl fluoride and 2 ‰ mercaptoethanols) polypide is placed in high-speed tissue mashing machine and is fully smashed to pieces, collect homogenate;By homogenate
It is centrifuged in 9000r/min high speed freezing centrifuges after 30min and collects supernatant, repeat the above steps 3 times is then combined with
Supernatant, by supernatant heating stirring 5min in 100 DEG C of thermostat water baths is placed in, and then treats its cooling 10min, then draws supernatant
Liquid is centrifuged 30min in 4800r/min high speed freezing centrifuges, finally take centrifuge tube supernatant (antibacterial peptide crude extract) be placed in it is little
During -20 DEG C of refrigerators are stored in test tube, as active component B.
Further, the preparation method of active component C is：Using Ligusticum wallichii as growth substrate, ganoderma lucidum mycelium is connect
Plant on matrix, by clever rhizome of chuanxiong mycoplasma obtained in two-way solid-fermented technique.
Further, all food-grades of the raw material components or pharmaceutical grade.
Comparative example 2
A kind of children's toothpaste, is made up of following parts by weight meter raw material：Particle diameter be the hydrated silica 7 of 100 mesh, silica 13,
Pteria martensii shell powder 16, dicalcium phosphate dihydrate 11, hydroxy-methyl cellulose sodium 7,28 parts of xylitol, carragheen
0.3rd, xanthans 0.4, C14 APGs 3, cocounut oil acyl CAB 0.4, flower color glycosides 3, mountain indigo plant red pigment 3, nine
In essential oil 1.1, Tea Polyphenols 1.3, active components A 13, active component C 9；The active component A is Chinese toon tender shoots water extraction
Thing；Active component C is clever rhizome of chuanxiong mycoplasma.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from red bayberry.
Further, the particle diameter of the pteria martensii oyster shell whiting powder is 80-120 mesh.
Further, the preparation method of the active component A is：To press after fresh Chinese toon tender shoots leaf belt cane chopping
Solid-liquid ratio 2（g）:3（mL）In adding distilled water, 8min is boiled, filtered, the soluble solid content being concentrated in water extract is
50-55%。
Further, the preparation method of active component C is：Using Ligusticum wallichii as growth substrate, ganoderma lucidum mycelium is connect
Plant on matrix, by clever rhizome of chuanxiong mycoplasma obtained in two-way solid-fermented technique.
Further, all food-grades of the raw material components or pharmaceutical grade.
Test example
Using embodiment 1-5 and the toothpaste of comparative example 1-2 component preparation as test group, its fungistatic effect is tested.
1. oxford cup ethods
The 1ml of bacterium solution 0., even spread is respectively added dropwise in the MH agar plate surfaces of diameter 90mm.With tweezers with sterile working skill
Art by the Oxford cuvette after sterilizing be gently put into it is above-mentioned be coated with the MH agar plates of bacterium, it is uniform on each flat board
Four Oxford cuvettes of placement.0.5g embodiments 1-5 and comparative example 1-2 component are taken, in being added slowly to Oxford cuvette, each
The test component of same dose is added in three Oxford cuvettes on flat board, in a remaining Oxford cuvette 0.5mL is added
Physiological saline does blank, carries out mark, and above-mentioned flat board is lain against into 37 DEG C of constant incubator culture 16-18h (white vacation silks
Saccharomycete culture 48h) result is observed afterwards.Inhibition zone is whether there is around observation cuvette, and measures its size.Every kind of bacterium is cooked 3
Repeat, the mean value with antibacterial circle diameter is as result of the test.
2. agar dilution
1. the preparation of pastille agar, takes the component of 0.2g embodiments 1 and is added in the flat board of a diameter of 90mm, then takes after thawing
The MH agar 1.8ml that 0. more than 5h is balanced in 50 DEG C of water-baths add (medicine in flat board:Agar=1:9), side edged
Flat board is rocked, medicine and culture medium is fully mixed.
2. inoculation micro sample adding appliance takes the defined area that 2 μ l bacterium solutions are inoculated into flat board, makes the bacterium solution formed after inoculation
Loop diameter about 5-8mm.First it is inoculated with during inoculation containing the low flat board of concentration, inoculates containing the high flat board of concentration, is finally inoculated with not
The growth control flat board of drug containing, to check whole process of the test in test bacterium existing state.
3. cultivate mobile flat board after vaccination bacterium solution is done, put 37 DEG C of culture 16-20h (candida albicans bacterium cultivates 48h)
。
4. result judges that with the lowest concentration of drug on the MH agar plates for occurring without bacterium colony be the medicine to detecting bacterium most
Low Mlc (MIC), single colony growth is negligible.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be in other specific forms realized.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of specification is only that for clarity those skilled in the art should
Using specification as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.The ins and outs not described in detail in the present invention, can pass through arbitrary in this area
Prior art is realized.Particularly, all technical characterstics not described in detail can be realized by any prior art in the present invention.
Claims (6)
1. a kind of children's toothpaste, it is characterised in that be made up of following parts by weight meter raw material：Particle diameter is the hydrated silica of 100 mesh
6-9, silica 1 1-15, pteria martensii shell powder 13-21, dicalcium phosphate dihydrate 8-14, hydroxy-methyl cellulose sodium
5-9, xylitol 23-37 parts, carragheen 0.1-0.5, xanthans 0.2-0.7, C14 APG 2-5, cocounut oil acyl propyl group
Glycine betaine 0.3-0.9, flower color glycosides 2-4, mountain indigo plant red pigment 2-4, kamuning essential oil 0.9-1.3, Tea Polyphenols 1-2, activity
Composition A 11-17, active component B 13-19, active component C 7-11；The active component A is Chinese toon tender shoots water extract；It is described
Active component B is yellow meal worm antibacterial peptide；Active component C is clever rhizome of chuanxiong mycoplasma.
2. children's toothpaste according to claim 1, it is characterised in that the particle diameter of the pteria martensii oyster shell whiting powder is
80-120 mesh.
3. children's toothpaste according to claim 1, it is characterised in that the preparation method of the active component A is：Will be new
Solid-liquid ratio 2 is pressed after fresh Chinese toon tender shoots leaf belt cane chopping（g）:3（mL）In adding distilled water, 8min is boiled, filtered, concentration
Soluble solid content into water extract is 50-55%.
4. children's toothpaste according to claim 1, it is characterised in that the preparation method of active component B is：Take
Yellow meal worm larva, first rinses polypide 3 times with running water, then with distilled water flushing 3 times, then dips in dry polypide with filter paper, then uses
75% alcohol wipe polypide is sterilized;It is 1: 3 addition extract (0.05 mol/L second according to polypide quality and extracting liquid volume ratio
Sour ammonium buffer solution, pH=5.0,0.35g/mL phenylmethylsulfonyl fluorides and 2 ‰ mercaptoethanols) polypide is placed in high-speed organization smashes
Fully smash to pieces in broken machine, collect homogenate;Homogenate is centrifuged in 9000r/min high speed freezing centrifuges and receive after 30min
Collection supernatant, repeat the above steps 3 times are then combined with supernatant, supernatant are placed in heat in 100 DEG C of thermostat water baths and are stirred
5min is mixed, its cooling 10min is then treated, then Aspirate supernatant is centrifuged 30min in 4800r/min high speed freezing centrifuges, most
After take centrifuge tube supernatant (antibacterial peptide crude extract) and be placed in small test tube and be stored in -20 DEG C of refrigerators, as active component B.
5. children's toothpaste according to claim 1, it is characterised in that the preparation method of active component C is：With river
Rhizome of chuanxiong is inoculated in ganoderma lucidum mycelium on matrix as growth substrate, by clever rhizome of chuanxiong mycoplasma obtained in two-way solid-fermented technique.
6. children's toothpaste according to claim 1, it is characterised in that all food-grades of the raw material components or medicine
Level.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611111674.4A CN106580771A (en) | 2016-12-06 | 2016-12-06 | Children's toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611111674.4A CN106580771A (en) | 2016-12-06 | 2016-12-06 | Children's toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106580771A true CN106580771A (en) | 2017-04-26 |
Family
ID=58596785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611111674.4A Pending CN106580771A (en) | 2016-12-06 | 2016-12-06 | Children's toothpaste |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233228A (en) * | 2017-07-20 | 2017-10-10 | 杭州坦珮信息技术有限公司 | A kind of manufacture method of anti-halitosis and carious tooth toothpaste |
| CN109481360A (en) * | 2018-09-05 | 2019-03-19 | 上海全力日用品有限公司 | Whitening type pure plant nano silver healthy mouth toothpaste |
-
2016
- 2016-12-06 CN CN201611111674.4A patent/CN106580771A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233228A (en) * | 2017-07-20 | 2017-10-10 | 杭州坦珮信息技术有限公司 | A kind of manufacture method of anti-halitosis and carious tooth toothpaste |
| CN109481360A (en) * | 2018-09-05 | 2019-03-19 | 上海全力日用品有限公司 | Whitening type pure plant nano silver healthy mouth toothpaste |
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Application publication date: 20170426 |