CN106580849A - Natural plant component toothpaste - Google Patents
Natural plant component toothpaste Download PDFInfo
- Publication number
- CN106580849A CN106580849A CN201611110768.XA CN201611110768A CN106580849A CN 106580849 A CN106580849 A CN 106580849A CN 201611110768 A CN201611110768 A CN 201611110768A CN 106580849 A CN106580849 A CN 106580849A
- Authority
- CN
- China
- Prior art keywords
- active component
- supernatant
- natural plant
- toothpaste
- polypide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides natural plant component toothpaste. The natural plant component toothpaste is designed by selecting the low-irritation raw materials, has little injury to children dentistry; an active component A, an active component B and an active component C contain the natural sterilization and nutrition components, are effected on the cytomembrane of bacteria in oral cavity, then destroy the completeness and generate perforation, so that the cellular content overflows the extracellular region and dies, or the antimicrobial peptide is effected on membrane protein to cause coagulation, inactivation and ion channels, membrane permeability change is generated to cause bacterial death, the natural plant component toothpaste has certain auxiliary effect on treatment of oral disease, and is the children toothpaste by taking moth resistance and nutrition idea as the main starting points.
Description
Technical field
The invention belongs to daily-use chemical industry product technical field, and in particular to a kind of natural plant composition toothpaste.
Background technology
This colony of child represents the following of country and wishes, their physical and mental health and growth enjoy each family and
The concern of the whole society.As a rule, child refers to the colony of 3-12 year.The colony of 3-6 year age bracket is preschooler;
The colony of 6-12 year age bracket is school age population.Preschooler self care ability is poor, relies primarily on the head of a family and child is old
Teacher guides and helps;School age population starts to accept the education, and big colony's sexual activity increases, and existence general knowledge and self care ability have
Certain raising, but the guidance of the head of a family and teacher is still needed to, they are declared with the using method for passing through oral care knowledge and oral-cavity article
It is very important.
Oral health care of children affects very big to its physically and mentally healthy and later growth, and toothpaste is oral health care product
Most important one in race, suitable Pediatric Oral Emergency physiological characteristicies and the toothpaste using feature at heart how are developed, use for reference flourishing state
The newest research results of family's children's toothpaste, are that research staff must the comprehensive important topic thought deeply.
Pediatric Oral Emergency main feature can summarize the following aspects:
1. oral mucosa opposing environmental stimuli power is poor, subject to damage.
2. tooth is delicate easily receives pressure injury.
3. decayed tooth is also easy to produce, if controlling bad, hidden danger can be left.
4. oral health care product, toothpaste, toothbrush, collutory etc. are used, because its method is improper and sense of self-protection
Difference easily occurs to swallow by mistake and injure oral cavity tissue problem.
5. it is incorrect due to some bad dietary habit and using oral health-care product method, to later dental growth and
Oral health has undesirable effect.
Oral cavity health care knowledge is passed through to child a surname, correct guiding uses oral health care product, exploitation to be adapted to the mouth of child's feature
Chamber articles for use, this will be the cause that the whole society pays close attention to jointly.Toothpaste research staff should be explored in terms of the exploitation of children's toothpaste newly
Method.
The content of the invention
In view of this, the present invention provides a kind of natural plant composition toothpaste, researches and develops mainly for child, the toothpaste of the present invention
It is little to oral cavity irritation on mucous membrane, can effective teenager teeth, eat by mistake it is oral after it is safe and harmless, with special color and delicate fragrance,
The desire that child can be caused to brush teeth, is conducive to growth and the oral health of teenager teeth.
The technical scheme is that：A kind of natural plant composition toothpaste, is made up of following parts by weight meter raw material：Particle diameter
For the hydrated silica 6-9 of 100 mesh, Sorbitol 11-15, Paphia Undulata shell powder 13-21, dicalcium phosphate dehydrate 8-14,
Tertiary sodium phosphate 5-9, xylitol 23-37 parts, carrageenan 0.1-0.5, xanthan gum 0.2-0.7, bathypelagic fish oil 2-5, cocos nucifera oil acyl
CAB 0.3-0.9, flower color glycosides 2-4, anthocyanidin 2-4, Fructus Pruni pseudocerasi extract 0.9-1.3, Radix Oenotherae erythrosepalae quintessence oil 1-
2nd, active components A 11-17, active component B 13-19, active component C 7-11；The active component A is Herba humuli scandentis crude extract；Institute
Active component C is stated for diamondback moth larvae antibacterial peptide.
Further, the particle diameter of the Paphia Undulata conch meal powder is 80-120 mesh.
Further, the preparation method of the active component A is：Prepare Herba humuli scandentis herb, stalk is cut into into 2-4cm length
Section, is smashed to pieces together with leaf, 50 DEG C of freeze-day with constant temperature, with the screen filtration of 200 mesh, collects the ultra-micro powder after sieving, standby；Press
60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate prepares aqueous two-phase extraction solvent, and solid-liquid ratio 1: 40g/mL is prepared
Aqueous two-phase extraction solvent, soaks 30 min at 60 DEG C, then extracts 50min under ultrasonic extraction instrument, and condition is horn
6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing are filtered, and are removed solid and are sunk
Filtrate is placed in concentrating under reduced pressure in Multi-example Parallel evaporator by mud matter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 17% Radix Scutellariae, 16% Herba Euphorbiae Humifusae, 28% old
Stork grass, 19% Radix Sanguisorbae, 20% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Diamondback moth larvae is taken, with distilled water flushing 3 times, then
Dry polypide is dipped in filter paper, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is carried according to polypide quality and extracting liquid volume ratio
Take liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols)
Polypide is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min high speed frozen centrifugations
Supernatant is collected after 30min is centrifuged in machine, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in 100 DEG C
Heated and stirred 5min in thermostat water bath, then treats its cooling 10min, then Aspirate supernatant 4800r/min freeze at a high speed from
30min is centrifuged in scheming, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators
In, as active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
The beneficial effects of the present invention is：The plant toothpaste of the present invention, is primarily directed to a natural plant of child's research and development
Thing component dentifrice.In the present invention, it is used as the essence of toothpaste, pigment and preservative using active skull cap components, by activearm
Divide the effect of A, the natural antiseptic agent of toothpaste can be become, coordinate the matched combined of flower color glycosides and anthocyanidin, being capable of basis
The pH changes in oral cavity, further change the color for producing foam, from the physiological characteristicies of child and it is curious at heart, increase child couple
The degree of liking of toothpaste, excites the enthusiasm and desire using toothpaste；The raw material design formulation of tooth-paste that the present invention selects zest low, it is right
The injury of Pediatric Oral Emergency is minimum；Natural sterilization and nutritional labeling are rich in active component A, active component B and active component C,
The cell membrane of antibacterial in oral cavity is acted on, its integrity is then destroyed and is produced perforation, so as to cause cellular content to overflow born of the same parents
It is outer and dead or antibacterial peptide acts on memebrane protein and causes cohesion, inactivation and ion channel, cause membrane permeability to change and cause carefully
Bacterium is dead, for treatment oral disease has certain auxiliary curative effect, is a main using mothproof and nutrition concept as what is developed
The children's toothpaste of starting point.
Specific embodiment
Technical scheme is clearly and completely described below in conjunction with the embodiment of the present invention, it is clear that retouched
The embodiment stated is only a part of embodiment of the invention, rather than the embodiment of whole.Based on the embodiment in the present invention, this
The every other embodiment obtained under the premise of creative work is not made by field those of ordinary skill, belongs to the present invention
The scope of protection.
Embodiment 1
A kind of natural plant composition toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, Pyrusussuriensiss of 100 mesh
Alcohol 13, Paphia Undulata shell powder 16, dicalcium phosphate dehydrate 11, tertiary sodium phosphate 7,28 parts of xylitol, carrageenan 0.3,
Xanthan gum 0.4, bathypelagic fish oil 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, anthocyanidin 3, Fructus Pruni pseudocerasi extract
1.1st, Radix Oenotherae erythrosepalae quintessence oil 1.3, active components A 13, active component B 16, active component C 9；The active component A is Herba humuli scandentis
Crude extract；Active component C is diamondback moth larvae antibacterial peptide.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from Fructus Myricae rubrae.
Further, the particle diameter of the Paphia Undulata conch meal powder is 110 mesh.
Further, the preparation method of the active component A is：Prepare Herba humuli scandentis herb, stalk is cut into into 2-4cm length
Section, is smashed to pieces together with leaf, 50 DEG C of freeze-day with constant temperature, with the screen filtration of 200 mesh, collects the ultra-micro powder after sieving, standby；Press
60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate prepares aqueous two-phase extraction solvent, and solid-liquid ratio 1: 40g/mL is prepared
Aqueous two-phase extraction solvent, soaks 30 min at 60 DEG C, then extracts 50min under ultrasonic extraction instrument, and condition is horn
6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing are filtered, and are removed solid and are sunk
Filtrate is placed in concentrating under reduced pressure in Multi-example Parallel evaporator by mud matter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 17% Radix Scutellariae, 16% Herba Euphorbiae Humifusae, 28% old
Stork grass, 19% Radix Sanguisorbae, 20% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Diamondback moth larvae is taken, with distilled water flushing 3 times, then
Dry polypide is dipped in filter paper, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is carried according to polypide quality and extracting liquid volume ratio
Take liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols)
Polypide is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min high speed frozen centrifugations
Supernatant is collected after 30min is centrifuged in machine, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in 100 DEG C
Heated and stirred 5min in thermostat water bath, then treats its cooling 10min, then Aspirate supernatant 4800r/min freeze at a high speed from
30min is centrifuged in scheming, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators
In, as active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Natural plant composition toothpaste of the present invention can adopt the conventional method of this area to prepare completely, such as《Detergent compositions
Workshop manual》(Xu Baocai etc. writes, Chemical Industry Press, chemistry and applied chemistry publishing centre, January in 2006 the
1 edition) toothpaste making process disclosed in the 594-597 page is prepared.Specifically, the present embodiment natural plant composition
The preparation method of toothpaste is：After above-mentioned raw materials component is weighed, in pre-dispersed kettle, dispersion, mixing, open cream kettle vacuum pumping processed
Enter above-mentioned liquid material, then drive scraper, agitator and colloid mill, after 50 minutes, close colloid mill, agitator and scraper successively, break
Vacuum, obtains natural plant composition toothpaste.
Obviously, the preparation method of toothpaste is prior art in the present invention, not special character, and the present invention's mainly changes
Enter to be that the difference of formula.
Embodiment 2
A kind of natural plant composition toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 6, Pyrusussuriensiss of 100 mesh
Alcohol 11, Paphia Undulata shell powder 13, dicalcium phosphate dehydrate 8, tertiary sodium phosphate 5,23 parts of xylitol, carrageenan 0.1,
Xanthan gum 0.2, bathypelagic fish oil 2, cocos nucifera oil acyl CAB 0.3, flower color glycosides 2, anthocyanidin 2, Fructus Pruni pseudocerasi extract
0.9th, Radix Oenotherae erythrosepalae quintessence oil 1, active components A 11, active component B 13, active component C 7；The active component A is that Herba humuli scandentis are thick
Extract；Active component C is diamondback moth larvae antibacterial peptide.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from Rhizoma Dioscoreae esculentae.
Further, the particle diameter of the Paphia Undulata conch meal powder is 120 mesh.
Further, the preparation method of the active component A is：Prepare Herba humuli scandentis herb, stalk is cut into into 2-4cm length
Section, is smashed to pieces together with leaf, 50 DEG C of freeze-day with constant temperature, with the screen filtration of 200 mesh, collects the ultra-micro powder after sieving, standby；Press
60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate prepares aqueous two-phase extraction solvent, and solid-liquid ratio 1: 40g/mL is prepared
Aqueous two-phase extraction solvent, soaks 30 min at 60 DEG C, then extracts 50min under ultrasonic extraction instrument, and condition is horn
6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing are filtered, and are removed solid and are sunk
Filtrate is placed in concentrating under reduced pressure in Multi-example Parallel evaporator by mud matter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 17% Radix Scutellariae, 16% Herba Euphorbiae Humifusae, 28% old
Stork grass, 19% Radix Sanguisorbae, 20% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Diamondback moth larvae is taken, with distilled water flushing 3 times, then
Dry polypide is dipped in filter paper, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is carried according to polypide quality and extracting liquid volume ratio
Take liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols)
Polypide is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min high speed frozen centrifugations
Supernatant is collected after 30min is centrifuged in machine, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in 100 DEG C
Heated and stirred 5min in thermostat water bath, then treats its cooling 10min, then Aspirate supernatant 4800r/min freeze at a high speed from
30min is centrifuged in scheming, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators
In, as active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Embodiment 3
A kind of natural plant composition toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 9, Pyrusussuriensiss of 100 mesh
Alcohol 15, Paphia Undulata shell powder 21, dicalcium phosphate dehydrate 14, tertiary sodium phosphate 9,37 parts of xylitol, carrageenan 0.5, Huang
Virgin rubber 0.7, C12 alkyl polyglucoside 5, cocos nucifera oil acyl CAB 0.9, flower color glycosides 4, anthocyanidin 4, Fructus Pruni pseudocerasi extract
1.3rd, Radix Oenotherae erythrosepalae quintessence oil 2, active components A 17, active component B 19, active component C 11；The active component A is that Herba humuli scandentis are thick
Extract；Active component C is diamondback moth larvae antibacterial peptide.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from purple cabbage.
Further, the particle diameter of the Paphia Undulata conch meal powder is 80 mesh.
Further, the preparation method of the active component A is：Prepare Herba humuli scandentis herb, stalk is cut into into 2-4cm length
Section, is smashed to pieces together with leaf, 50 DEG C of freeze-day with constant temperature, with the screen filtration of 200 mesh, collects the ultra-micro powder after sieving, standby；Press
60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate prepares aqueous two-phase extraction solvent, and solid-liquid ratio 1: 40g/mL is prepared
Aqueous two-phase extraction solvent, soaks 30 min at 60 DEG C, then extracts 50min under ultrasonic extraction instrument, and condition is horn
6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing are filtered, and are removed solid and are sunk
Filtrate is placed in concentrating under reduced pressure in Multi-example Parallel evaporator by mud matter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 17% Radix Scutellariae, 16% Herba Euphorbiae Humifusae, 28% old
Stork grass, 19% Radix Sanguisorbae, 20% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Diamondback moth larvae is taken, with distilled water flushing 3 times, then
Dry polypide is dipped in filter paper, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is carried according to polypide quality and extracting liquid volume ratio
Take liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols)
Polypide is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min high speed frozen centrifugations
Supernatant is collected after 30min is centrifuged in machine, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in 100 DEG C
Heated and stirred 5min in thermostat water bath, then treats its cooling 10min, then Aspirate supernatant 4800r/min freeze at a high speed from
30min is centrifuged in scheming, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators
In, as active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Embodiment 4
A kind of natural plant composition toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, Pyrusussuriensiss of 100 mesh
Alcohol 13, Paphia Undulata shell powder 16, dicalcium phosphate dehydrate 11, tertiary sodium phosphate 7,28 parts of xylitol, carrageenan 0.3,
Xanthan gum 0.4, bathypelagic fish oil 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, anthocyanidin 3, Fructus Pruni pseudocerasi extract
1.1st, Radix Oenotherae erythrosepalae quintessence oil 1.3, active components A 12, active component B 17, active component C 8；The active component A is Herba humuli scandentis
Crude extract；Active component C is diamondback moth larvae antibacterial peptide.
Further, the preparation method of the active component A is：Prepare Herba humuli scandentis herb, stalk is cut into into 2-4cm length
Section, is smashed to pieces together with leaf, 50 DEG C of freeze-day with constant temperature, with the screen filtration of 200 mesh, collects the ultra-micro powder after sieving, standby；Press
60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate prepares aqueous two-phase extraction solvent, and solid-liquid ratio 1: 40g/mL is prepared
Aqueous two-phase extraction solvent, soaks 30 min at 60 DEG C, then extracts 50min under ultrasonic extraction instrument, and condition is horn
6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing are filtered, and are removed solid and are sunk
Filtrate is placed in concentrating under reduced pressure in Multi-example Parallel evaporator by mud matter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 17% Radix Scutellariae, 16% Herba Euphorbiae Humifusae, 28% old
Stork grass, 19% Radix Sanguisorbae, 20% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Diamondback moth larvae is taken, with distilled water flushing 3 times, then
Dry polypide is dipped in filter paper, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is carried according to polypide quality and extracting liquid volume ratio
Take liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols)
Polypide is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min high speed frozen centrifugations
Supernatant is collected after 30min is centrifuged in machine, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in 100 DEG C
Heated and stirred 5min in thermostat water bath, then treats its cooling 10min, then Aspirate supernatant 4800r/min freeze at a high speed from
30min is centrifuged in scheming, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators
In, as active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Embodiment 5
A kind of natural plant composition toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, Pyrusussuriensiss of 100 mesh
Alcohol 13, Paphia Undulata shell powder 16, dicalcium phosphate dehydrate 11, tertiary sodium phosphate 7,28 parts of xylitol, carrageenan 0.3,
Xanthan gum 0.4, bathypelagic fish oil 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, anthocyanidin 3, Fructus Pruni pseudocerasi extract
1.1st, Radix Oenotherae erythrosepalae quintessence oil 1.3, active components A 16, active component B 14, active component C 10；The active component A is Herba humuli scandentis
Crude extract；Active component C is diamondback moth larvae antibacterial peptide.
Particularly, heretofore described flower color glycosides is the natural anthocyanin extracted from Japanese red autumnal leaves Radix Berberidis Amurensis.
Further, the particle diameter of the Paphia Undulata conch meal powder is 105 mesh.
Further, the preparation method of the active component A is：Prepare Herba humuli scandentis herb, stalk is cut into into 2-4cm length
Section, is smashed to pieces together with leaf, 50 DEG C of freeze-day with constant temperature, with the screen filtration of 200 mesh, collects the ultra-micro powder after sieving, standby；Press
60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate prepares aqueous two-phase extraction solvent, and solid-liquid ratio 1: 40g/mL is prepared
Aqueous two-phase extraction solvent, soaks 30 min at 60 DEG C, then extracts 50min under ultrasonic extraction instrument, and condition is horn
6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing are filtered, and are removed solid and are sunk
Filtrate is placed in concentrating under reduced pressure in Multi-example Parallel evaporator by mud matter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component B is：In mass ratio by 17% Radix Scutellariae, 16% Herba Euphorbiae Humifusae, 28% old
Stork grass, 19% Radix Sanguisorbae, 20% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Diamondback moth larvae is taken, with distilled water flushing 3 times, then
Dry polypide is dipped in filter paper, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is carried according to polypide quality and extracting liquid volume ratio
Take liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols)
Polypide is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min high speed frozen centrifugations
Supernatant is collected after 30min is centrifuged in machine, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in 100 DEG C
Heated and stirred 5min in thermostat water bath, then treats its cooling 10min, then Aspirate supernatant 4800r/min freeze at a high speed from
30min is centrifuged in scheming, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators
In, as active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Comparative example 1
A kind of natural plant composition toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, Pyrusussuriensiss of 100 mesh
Alcohol 13, Paphia Undulata shell powder 16, dicalcium phosphate dehydrate 11, tertiary sodium phosphate 7,28 parts of xylitol, carrageenan 0.3,
Xanthan gum 0.4, bathypelagic fish oil 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, anthocyanidin 3, Fructus Pruni pseudocerasi extract
1.1st, Radix Oenotherae erythrosepalae quintessence oil 1.3, active component B 16, active component C 9；Active component C is diamondback moth larvae antibacterial peptide.
Further, the preparation method of active component B is：In mass ratio by 17% Radix Scutellariae, 16% Herba Euphorbiae Humifusae, 28% old
Stork grass, 19% Radix Sanguisorbae, 20% deionized water, decoct 2 times, collecting decoction, filtered through gauze, and filtrate heating is concentrated into 2g/mL containing crude drug,
100 DEG C of sterilizing 10min, 4 DEG C save backup.
Further, the preparation method of active component C is：Diamondback moth larvae is taken, with distilled water flushing 3 times, then
Dry polypide is dipped in filter paper, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is carried according to polypide quality and extracting liquid volume ratio
Take liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols)
Polypide is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min high speed frozen centrifugations
Supernatant is collected after 30min is centrifuged in machine, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in 100 DEG C
Heated and stirred 5min in thermostat water bath, then treats its cooling 10min, then Aspirate supernatant 4800r/min freeze at a high speed from
30min is centrifuged in scheming, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators
In, as active component C.
Further, all food stage of the raw material components or pharmaceutical grade.
Comparative example 2
A kind of natural plant composition toothpaste, is made up of following parts by weight meter raw material：Particle diameter is the hydrated silica 7, Pyrusussuriensiss of 100 mesh
Alcohol 13, Paphia Undulata shell powder 16, dicalcium phosphate dehydrate 11, tertiary sodium phosphate 7,28 parts of xylitol, carrageenan 0.3,
Xanthan gum 0.4, bathypelagic fish oil 3, cocos nucifera oil acyl CAB 0.4, flower color glycosides 3, anthocyanidin 3, Fructus Pruni pseudocerasi extract
1.1st, Radix Oenotherae erythrosepalae quintessence oil 1.3, active components A 13, active component C 9；The active component A is Herba humuli scandentis crude extract；The work
Property component C be diamondback moth larvae antibacterial peptide.
Further, the preparation method of the active component A is：Prepare Herba humuli scandentis herb, stalk is cut into into 2-4cm length
Section, is smashed to pieces together with leaf, 50 DEG C of freeze-day with constant temperature, with the screen filtration of 200 mesh, collects the ultra-micro powder after sieving, standby；Press
60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate prepares aqueous two-phase extraction solvent, and solid-liquid ratio 1: 40g/mL is prepared
Aqueous two-phase extraction solvent, soaks 30 min at 60 DEG C, then extracts 50min under ultrasonic extraction instrument, and condition is horn
6mm, ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s, centrifuging and taking supernatant after extraction, Jing are filtered, and are removed solid and are sunk
Filtrate is placed in concentrating under reduced pressure in Multi-example Parallel evaporator by mud matter, obtains thick extracted extract, and 4 DEG C save backup.
Further, the preparation method of active component C is：Diamondback moth larvae is taken, with distilled water flushing 3 times, then
Dry polypide is dipped in filter paper, then is sterilized with 75% alcohol wipe polypide;It is that 1: 3 addition is carried according to polypide quality and extracting liquid volume ratio
Take liquid (0.05 mol/L ammonium acetate buffers, pH=5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols)
Polypide is placed in high-speed tissue mashing machine and fully smashs to pieces, collects homogenate;By homogenate in 9000r/min high speed frozen centrifugations
Supernatant is collected after 30min is centrifuged in machine, repeat the above steps 3 times are then combined with supernatant, supernatant is placed in 100 DEG C
Heated and stirred 5min in thermostat water bath, then treats its cooling 10min, then Aspirate supernatant 4800r/min freeze at a high speed from
30min is centrifuged in scheming, centrifuge tube supernatant (antibacterial peptide crude extract) is finally taken and is placed in small test tube and be stored in -20 DEG C of refrigerators
In, as active component C.
Test example
Toothpaste using embodiment 1-5 and the preparation of comparative example 1-2 component is tested as test group to its fungistatic effect.
1. oxford cup ethods
In each 0. 1ml of Deca bacterium solution of the MH agar plate surfaces of diameter 90mm, even spread.With tweezers with sterile working's skill
Art by the Oxford cuvette after sterilizing be gently put into it is above-mentioned be coated with the MH agar plates of antibacterial, it is uniform on each flat board
Four Oxford cuvettes of placement.0.5g embodiments 1-5 and comparative example 1-2 component are taken, is added slowly in the cuvette of Oxford, each
The test component of same dose is added in three Oxford cuvettes on flat board, in a remaining Oxford cuvette, 0.5mL is added
Normal saline does blank, carries out labelling, and above-mentioned flat board is lain against 37 DEG C of constant incubator culture 16-18h (white vacation silks
Yeast culture 48h) result is observed afterwards.Inhibition zone is whether there is around observation cuvette, and measure its size.Every kind of antibacterial is cooked 3
Repeat, the meansigma methodss with antibacterial circle diameter are as result of the test.
2. agar dilution
1. the preparation of pastille agar, takes 1 component of 0.2g embodiments and is added in the flat board of a diameter of 90mm, then take thawing after
The MH agar 1.8ml that 0. more than 5h is balanced in 50 DEG C of water-baths add (medicine in flat board:Agar=1:9), side edged
Flat board is rocked, medicine and culture medium is fully mixed.
2. inoculation micro sample adding appliance takes the defined area that 2 μ l bacterium solutions are inoculated into flat board, the bacterium solution formed after making inoculation
Loop diameter about 5-8mm.First it is inoculated with during inoculation containing the low flat board of concentration, inoculates containing the high flat board of concentration, be finally inoculated with not
The growth control flat board of drug containing, to check the existing state that bacterium is tested in whole process of the test.
3. cultivate mobile flat board after vaccination bacterium solution is done, put 37 DEG C of culture 16-20h (candida albicans bacterium cultivates 48h)
。
4. result judges that to occur without the lowest concentration of drug on the MH agar plates of bacterium colony be the medicine to detecting bacterium most
Low Mlc (MIC), single colony growth are negligible.
It is obvious to a person skilled in the art that the invention is not restricted to the details of above-mentioned one exemplary embodiment, Er Qie
In the case of spirit or essential attributes without departing substantially from the present invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, embodiment all should be regarded as exemplary, and be nonrestrictive, the scope of the present invention is by appended power
Profit is required rather than described above is limited, it is intended that all in the implication and scope of the equivalency of claim by falling
Change is included in the present invention.
Moreover, it will be appreciated that although this specification is been described by according to embodiment, not each embodiment is only wrapped
Containing an independent technical scheme, this narrating mode of description is only that those skilled in the art should for clarity
Using description as an entirety, the technical scheme in each embodiment can also Jing it is appropriately combined, form those skilled in the art
Understandable other embodiment.The ins and outs not described in detail in the present invention, can pass through arbitrary in this area
Prior art is realized.Particularly, in the present invention, all technical characterstics not described in detail can be realized by any prior art.
Claims (6)
1. a kind of natural plant composition toothpaste, it is characterised in that be made up of following parts by weight meter raw material：Particle diameter is 100 purposes
Hydrated silica 6-9, Sorbitol 11-15, Paphia Undulata shell powder 13-21, dicalcium phosphate dehydrate 8-14, tertiary sodium phosphate
5-9, xylitol 23-37 parts, carrageenan 0.1-0.5, xanthan gum 0.2-0.7, bathypelagic fish oil 2-5, cocos nucifera oil acyl CAB
0.3-0.9, flower color glycosides 2-4, anthocyanidin 2-4, Fructus Pruni pseudocerasi extract 0.9-1.3, Radix Oenotherae erythrosepalae quintessence oil 1-2, active components A
11-17, active component B 13-19, active component C 7-11；The active component A is Herba humuli scandentis crude extract；Active component C
For diamondback moth larvae antibacterial peptide.
2. natural plant composition toothpaste according to claim 1, it is characterised in that the Paphia Undulata conch meal powder
Particle diameter be 80-120 mesh.
3. natural plant composition toothpaste according to claim 1, it is characterised in that the preparation side of the active component A
Method is：Prepare Herba humuli scandentis herb, stalk is cut into into the section of 2-4cm length, is smashed to pieces with leaf together, 50 DEG C of freeze-day with constant temperature, with the sieve of 200 mesh
Net filtration, collects the ultra-micro powder after sieving, standby；Match somebody with somebody by 60% (volume fraction) ethanol+10% (volume fraction) ethyl acetate
Aqueous two-phase extraction solvent processed, solid-liquid ratio 1: 40g/mL prepare aqueous two-phase extraction solvent, and 30 min, Ran Hou are soaked at 60 DEG C
50min is extracted under ultrasonic extraction instrument, condition is horn 6mm, and ultrasonic power 800W, 50 DEG C of temperature, ultrasonic 6s, interval 5s extract
Rear centrifuging and taking supernatant is taken, Jing is filtered, and is removed solid precipitation slag, filtrate is placed in Multi-example Parallel evaporator and reduces pressure dense
Contracting, obtains thick extracted extract, and 4 DEG C save backup.
4. natural plant composition toothpaste according to claim 1, it is characterised in that the preparation side of active component B
Method is：In mass ratio by 17% Radix Scutellariae, 16% Herba Euphorbiae Humifusae, 28% Herba Erodii, 19% Radix Sanguisorbae, 20% deionized water, decoct 2 times, merge and decoct
Liquid, filtered through gauze, filtrate heating are concentrated into 2g/mL containing crude drug, 100 DEG C of sterilizing 10min, and 4 DEG C save backup.
5. natural plant composition toothpaste according to claim 1, it is characterised in that the preparation side of active component C
Method is：Diamondback moth larvae is taken, and with distilled water flushing 3 times, then dry polypide is dipped in filter paper, then is disappeared with 75% alcohol wipe polypide
Poison;According to polypide quality and extracting liquid volume ratio be 1: 3 add extracting solution (0.05 mol/L ammonium acetate buffers, pH=
5.0,0.35g/mL Phenylmethanesulfonyl fluorides and 2 ‰ mercaptoethanols) polypide is placed in high-speed tissue mashing machine and is fully smashed to pieces, receive
Collection homogenate;Supernatant is collected after homogenate is centrifuged 30min in 9000r/min High speed refrigerated centrifuges, repetition is above-mentioned
Step 3 time, is then combined with supernatant, and supernatant is placed in heated and stirred 5min in 100 DEG C of thermostat water baths, then treats which is cold
But 10min, then Aspirate supernatant is centrifuged 30min in 4800r/min High speed refrigerated centrifuges, finally takes centrifuge tube supernatant
(antibacterial peptide crude extract) is placed in small test tube and is stored in -20 DEG C of refrigerators, as active component C.
6. natural plant composition toothpaste according to claim 1, it is characterised in that all food of the raw material components
Level or pharmaceutical grade.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611110768.XA CN106580849A (en) | 2016-12-06 | 2016-12-06 | Natural plant component toothpaste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611110768.XA CN106580849A (en) | 2016-12-06 | 2016-12-06 | Natural plant component toothpaste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106580849A true CN106580849A (en) | 2017-04-26 |
Family
ID=58596208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611110768.XA Pending CN106580849A (en) | 2016-12-06 | 2016-12-06 | Natural plant component toothpaste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106580849A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233228A (en) * | 2017-07-20 | 2017-10-10 | 杭州坦珮信息技术有限公司 | A kind of manufacture method of anti-halitosis and carious tooth toothpaste |
-
2016
- 2016-12-06 CN CN201611110768.XA patent/CN106580849A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107233228A (en) * | 2017-07-20 | 2017-10-10 | 杭州坦珮信息技术有限公司 | A kind of manufacture method of anti-halitosis and carious tooth toothpaste |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Van Ermengem | A new anaerobic bacillus and its relation to botulism | |
| JP5667358B2 (en) | Aspergillus fermented composition of citrus peel | |
| CN102178844B (en) | Oral Chinese medicine preparation for treating gum swelling and pain and preparation method thereof | |
| CN105168038B (en) | Golden flower flower clay mask and preparation method thereof | |
| CN111437235B (en) | Rice composite fermentation product with anti-aging effect and preparation method and application thereof | |
| CN103655257A (en) | Chinese medicine hair nourishing shampoo and preparation method thereof | |
| CN103169127B (en) | Beverage prepared from honeysuckle flowers, chrysanthemums and peonies | |
| CN106562921A (en) | Liquid oral composition containing TCM active substances and tea tree essential oil | |
| CN105726439A (en) | Cordyceps cicadae whitening and moisturizing cosmeceutical and preparing method thereof | |
| CN104451927B (en) | A kind of Chinese medicine expelling parasite additive and application thereof | |
| CN110327246A (en) | A kind of mouthwash containing marine oligosaccharide | |
| CN106580769A (en) | Bacteriostatic and tooth-protecting toothpaste | |
| CN106580849A (en) | Natural plant component toothpaste | |
| CN106580771A (en) | Children's toothpaste | |
| CN106614137A (en) | Collecting method of monopterus albus mucus | |
| CN104288344A (en) | Applications of a Pu'er tea extract product in preparation of medicines or foods adjusting intestinal flora and relaxing the bowels | |
| JP2022551319A (en) | American cockroach extract, formulation, preparation method and use thereof | |
| CN103054839A (en) | Medicine for killing acid-fast staining positive (red) bacilli | |
| CN109010231A (en) | A kind of Haircare composition and preparation method thereof based on marine organism extract | |
| Goodale | The diagnosis and management of vasomotor disturbances of the upper air passages | |
| Koch | Aetiology of tuberculosis | |
| CN106692021A (en) | Tea cake hair-care composition and preparation method thereof | |
| CN107951813A (en) | A kind of antibacterial anti-inflammatory anti-acne repairs facial mask | |
| CN108066518A (en) | A kind of dog Chinese medicine bath lotion composition and preparation method thereof | |
| CN113827502B (en) | Application of cistanche deserticola polysaccharide in preparation of cosmetics with moisture absorption, moisturizing or relieving effects |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20170426 |