CN104451927B - A kind of Chinese medicine expelling parasite additive and application thereof - Google Patents
A kind of Chinese medicine expelling parasite additive and application thereof Download PDFInfo
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Abstract
A kind of Chinese medicine expelling parasite additive, is characterized in that, the parts by weight of the various bulk drugs of described Chinese medicine expelling parasite additive are: 10～20 parts of rhizoma atractylodis, 10～20 parts of peppermints, 10～20 parts of Radix zanthoxylis, 10～20 parts of kuh-sengs, 10～20 parts of climbing groundsels, 10～20 parts of kaempferia galamgas, 10～20 parts of calamus, 10～20 parts of tarragons, 10～20 parts of borneols, 10～20 parts of the flower buds of lily magnolia, 10～20 parts of the roots of Chinese wild ginger, 10～20 parts of cloves, windproof 10～20 parts, 10～20 parts of cassia twig, 10～20 parts of Chinese cassia trees, 10～20 parts of rhizoma cyperis, 10～20 parts of the bletilla striatas, 10～20 parts of eupatoriums, 10～20 parts of fish pelargoniums. The present invention adopts multiple extracted form natural plant composition, naturally gentle, and bite by mosquitos can be stoped, also the discomfort after bite by mosquitos can be alleviated rapidly, the pure gentleness of product, non-stimulated, the safer care of skin of giving adult. Allow people away from mosquito invasion in summer. The natural gentleness of underwear fabric of the present invention, safety, non-greasy, snug fit.
Description
Technical field
The present invention relates to contain the material that derives from plant, animal or mineral component, particularly a kind of Chinese medicine expelling parasite is addedAdd agent and application thereof.
Background technology
Bite by mosquitos can play bag, and this is mainly that skin has allergic reaction to the saliva of insect, some by bite by mosquitos after oneWheat harvesting period red packet all moves back to go down, and this is more serious, but bite by mosquitos is not what is asked greatly for most peopleTopic. For bite by mosquitos, present various folk prescriptions and medicine are very many, and folk prescription is not necessarily all effective to everyone, so,Blindly how do not hear of effect. But, common cooling ointment, essential wind oil one class have an alcoholic content, so skinThe people of skin sensitivity still lacks use as far as possible, and as for the medicine of steroids, antipruritic effect can be very obvious.
The dermatitis that bite by mosquitos causes in insect dermatitis is modal. Mosquito is stabbed skin by its mouthpart, its salivaLiquid or venom are invaded skin, and owing to containing plurality of antigens composition in the saliva of mosquito or the leachate of poison gland, these antigens are enteringAfter entering human body skin, can produce allergic reaction with antibody and cause inflammation. The local bleb, hemorrhage that produces of indivedual infants when seriousProperty the downright bad severe reaction that waits, be dermatology common disease disease in summer.
Bite by mosquitos is the maximum killer of sleep in summer, especially, concerning infant, because its skin is tender and lovely, is easy toBy red and swollen after bite by mosquitos, thereby cause skin infection. Summer, people came mosquito-expelling and antipruritic, deodorization and sterilization with floral water, if butImproper use not only can endanger healthy, and serious also can be fatal. Wherein mainly contain a lot of uses mistaken ideas. One, excessive useFor fear of bite by mosquitos, often a lot of floral water spread upon each position of whole body. But do like this, somebody there will be healthItch, emit the symptom of cold sweat, want appropriate so smear floral water, avoid health to occur bad reaction. Two, after trouble dermatitis, use flowerDew contains a kind of composition that is " Yi Moning ", and it can make mosquito lose the consciousness that people is bitten. If smeared after trouble dermatitisFloral water, not only can not treat dermatitis, and " Yi Moning " composition also can cause skin to occur allergic reaction, increases the weight of dermatitis symptom. Suffer fromThe patient of dermatitis can be dripped 4-5 and be dripped floral water on electric mat, can avoid again allergic by mosquito repellent. Three, be coated with after floral waterEnter immediately kitchen " igniting " a lot of people that cook and all ignored the points for attention after floral water uses: please avoid burning things which may cause a fire disaster and use and store upHide. This is because contain 75% alcohol and 5% perfume ingredient in floral water, once will light near burning things which may cause a fire disaster. So smearedAfter floral water, do not use immediately fire or close burning things which may cause a fire disaster, such as: kindle mosquito repellent incense, light a cigarette, use the kitchen range of naked light etc. Four, liquid distilled from honeysuckle flowers or lotus leavesWater should spread upon the arms and legs portion that mosquito often bites in right amount; The people of skin sensitivity, can drop in floral water on electric mat,Or cooling ointment uncap is placed on to bedside, can avoid again allergic by mosquito repellent like this; While using floral water to child,To be diluted 4-5 doubly, in order to avoid stimulate the tender and lovely skin of child.
No matter be electric mat or Electric liquid mosquito-repellent incense, all contain the mosquito repellent of harmful organic compound electric mosquito repellentPrinciple is that Dalmatian chrysanthemum etc. is sucked in anti-mosquito incense sheet, evaporates, if drip upper several essential wind oil better effects if after heating. Liquid electricity mosquitoPerfume (or spice) is to utilize hair suction pipe principle, and continuous heating discharges insecticide substance, and it is the most convenient to use. By using calculating in eight hours every day,One bottle of mosquito-repellent incense liquid can use 30 days continuously, has exempted the trouble of changing electric mat every day. As used in closed room, mayCan produce bad reaction. Therefore while, using electric mosquito repellent, should maintain the circulation of air. The optimal use time of electric mosquito repellent is in the first half of sleepingHour.
Now, the increasing the weight of of environmental pollution, microorganism is more and more serious on the impact of health, the micro-life in the NatureThing is ubiquitous, all-pervasive. The insect that some are harmful, with the sweat on dress ornament next to the skin, blood, phat fat, skinBits wait as nutrition, and in body temperature and moistening environment, breeding rapidly, produces bad compound, volatilizes unpleasant gasTaste, harmful, induce an illness. These factors make people more and more higher for the requirement of functions of textile fabrics, wishIt can possess several functions simultaneously, as also can hair tonic anion in meeting expelling parasite to improve surrounding air quality.
String is a kind of natural polymer subbundle, and its biological structure is made up of countless cells, wherein cell membraneIn material, contain cellulose, hemicellulose and lignin. Therefore, string has obvious biological nature, and it is often subject toThe infringement of biology and microorganism. Especially (comprise the natural wooden fiber such as timber, bamboo wood and cotton, fiber crops, crops with stringThe non-woods such as stalk and part secondary stock) for the sponge that primary raw material is prepared from, be applied to buffering, require it to there is certain durability when in the field such as packaging, building, insulation and sound insulation.
In recent years, the market demand of viscose rayon is the trend of sustainable growth, cotton, short rayon fiber, terylene short fiberDomestic three large main cotton spinning raw material, particularly cotton and short rayon fibers, owing to belonging to cellulose fibre together, in physical propertyWith in wearability, have great similitude, both have mutually substituting, therefore viscose rayon is widely used.Viscose rayon is regenerated celulose fibre, and sucting wet air permeability is good, has good degradability and recoverable, hasThe feature that a lot of chemical fibres do not have, can, by changing spinning solution component and production technology, change common viscose fiberProperty, increases that it is functional, as antibiotic property, hair tonic anion, insect-repellent etc.
Obtain the viscose rayon with function for expelling pests, just need in rayon spinning liquid, add pest repellant, both blendSpinning becomes Multifunctional adhesive fiber. For functional additive being coexisted and playing a role, the selection of additive is extremely important, it must meet to coexist does not affect its function, and in water, in alkali and acid, solubility is extremely low, to strong acid, alkali, oxidantThe property learned and hot property are stable, and spinning process, fibre property are had no adverse effects, and have spinnability, and medium can be from fibrous insideTransfer to the surface of fiber, toxicity and ecological aspect performance can accept. Must prevent that the valuable character of fiber from beingMany impacts should be tried to achieve overall balance in conflicting effect, make fibrous material obtain higher use value and morePurposes widely.
The present invention has selected the merit of natural traditional Chinese medicine plant extracts as Multifunctional adhesive fiber from numerous pest repellantsEnergy additive is with development Multifunctional adhesive fiber.
Vast territory and abundant resources in China, abounds with various natural Chinese medicinal herb. Chinese herbal medicine is traditional culture marrow. By traditional Chinese medicine theory withModern science and technology combines, and by various modern techniques such as refinement, extractions, Chinese herbal medicine elite is used for to mosquito repellent product series, spyResearch and develop herbal type high-quality and driven kill mosquito product, adopted multiple extracted form natural plant composition, naturally gentle, can alleviate rapidly mosquitoDiscomfort after biting, the pure gentleness of product, non-stimulated, the safer care of skin of giving adult. Bite by mosquitos brings to adultSkin discomfort, order adult's skin is refrigerant pleasant, away from summer mosquito invade and harass. Natural gentleness, safety, non-greasy.
Summary of the invention
Technical problem to be solved by this invention is, the present invention adopts multiple extracted form natural plant composition, naturally gentle,Bite by mosquitos can be stoped, also the discomfort after bite by mosquitos can be alleviated rapidly, the pure gentleness of product, non-stimulated, give the flesh of being grown upThe care that skin and adult are safer. Allow people away from mosquito invasion in summer. The natural gentleness of underwear fabric of the present invention, safety, not oilyGreasy, snug fit.
For solving these technical problems, the invention provides a kind of Chinese medicine expelling parasite additive, described in it, Chinese medicine expelling parasite is addedThe parts by weight of the various bulk drugs of agent are: 10～20 parts of rhizoma atractylodis, 10～20 parts of peppermints, 10～20 parts of Radix zanthoxylis, kuh-seng 10～20Part, 10～20 parts of climbing groundsels, 10～20 parts of kaempferia galamgas, 10～20 parts of calamus, 10～20 parts of tarragons, 10～20 parts of borneols, the flower bud of lily magnolia 10～20 parts, 10～20 parts of the roots of Chinese wild ginger, 10～20 parts of cloves, windproof 10～20 parts, 10～20 parts of cassia twig, 10～20 parts of Chinese cassia trees, rhizoma cyperi10～20 parts, 10～20 parts of the bletilla striatas, 10～20 parts of eupatoriums, 10～20 parts of fish pelargoniums.
Described Chinese medicine expelling parasite additive, described in it, the parts by weight of the various bulk drugs of Chinese medicine expelling parasite additive are: rhizoma atractylodis 10～15 parts, 10～15 parts of peppermints, 10～15 parts of Radix zanthoxylis, 10～15 parts of kuh-sengs, 10～15 parts of climbing groundsels, 10～15 parts of kaempferia galamgas,10～15 parts of calamus, 10～15 parts of tarragons, 10～15 parts of borneols, 10～20 parts of the flower buds of lily magnolia, 10～20 parts of the roots of Chinese wild ginger, cloves 10～20Part, windproof 10～20 parts, 10～20 parts of cassia twig, 10～20 parts of Chinese cassia trees, 10～20 parts of rhizoma cyperis, 10～20 parts of the bletilla striatas, eupatorium 10～20 parts, 10～20 parts of fish pelargoniums.
Described Chinese medicine expelling parasite additive, is characterized in that, the parts by weight of the various bulk drugs of described Chinese medicine expelling parasite additiveFor: 10～20 parts of rhizoma atractylodis, 10～20 parts of peppermints, 10～20 parts of Radix zanthoxylis, 10～20 parts of kuh-sengs, 10～20 parts of climbing groundsels, kaempferia galamga10～20 parts, 10～20 parts of calamus, 10～20 parts of tarragons, 10～20 parts of borneols, 10～15 parts of the flower buds of lily magnolia, 10～15 parts of the roots of Chinese wild ginger, fourthFragrant 10～15 parts, windproof 10～15 parts, 10～15 parts of cassia twig, 10～15 parts of Chinese cassia trees, 10～15 parts of rhizoma cyperis, 10～15 parts of the bletilla striatas,10～15 parts of eupatoriums, 10～15 parts of fish pelargoniums.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Chinese medicine expelling parasite additive, and its feature existsIn, the preparation method of described Chinese medicine expelling parasite additive comprises the following steps:
A. get all bulk drugs way of distillation and be vaporized into crystallization, pulverized dusting cover stand-by, as component 1;
B. distillation test residue is extracted 2 times by ethanol heat, merge concentrated extracting solution, as component 2;
E. after component 1 being mixed with component 2, mix well, sterilization tinning is stand-by.
In described step a, can first all bulk drugs be distilled with steam method, obtain crystal, then pulverize mistake120-150 mesh sieve, for subsequent use as component 1.
In described step b, the residue of the bulk drug that the way of distillation can be extracted, adds and accounts for the second that its quality 5-10 doubly measuresAlcohol soaks 4-6 hour, and heating is extracted 2 times, and each 1-2 hour, merges extract, after leaving standstill, removes supernatant, then 100-120 orderFilter, then be the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C1.25 filtrate, as component 2.
In described step c, the powder crystallization of pulverizing can be mixed in the filtrate of component 2, through ultraviolet radiation for sterilizing and disinfectingStand-by afterwards.
For solving the problems of the technologies described above, the present invention also provides a kind of peppermint underwear fabric, the preparation of described underwear fabricRaw material comprises: the Chinese medicine expelling parasite additive of mint fibers and aforementioned any one.
The preparation method of described underwear fabric can comprise the following steps:
A. the purification step of mint fibers;
B. cellulosic activation step;
C. cellulose is at the dissolving step of copper ammon solution;
D. the step of spinning.
The step of described d. spinning may further include: the preparation of spinning solution, filtration, deaeration, regeneration, acidWash, washing, hot drawing-off.
The present invention adopts multiple extracted form natural plant composition, naturally gentle, can stop bite by mosquitos, also can alleviate rapidlyDiscomfort after bite by mosquitos, the pure gentleness of product, non-stimulated, skin and the safer care of adult of giving adult. Make people far awayFrom mosquito invasion in summer. The natural gentleness of the present invention, safety, non-greasy, snug fit.
The technique effect that the present invention is useful is, a kind of novel underwear fabric is provided. Have although domestic much about drivingWorm arranges and the research of expelling parasite textile material, mostly has obvious defect, drives buffalo gnat fly persistence poor. The present invention is with peppermintPlant and natural to drive the agent of buffalo gnat fly be raw material, utilizes copper ammon solution wet spinning to produce regenerated celulose fibre. This production methodBe a kind of free of contamination Green production method, have good market prospects, at home and abroad insect-repellent fiber developing material still belongs to firstExample. By the anthelminthic effect of the expelling parasite regenerated celulose fibre to prepared, structure, physical and mechanical properties and the weaving of fiberPrinting and dyeing machinability is carried out overall merit, determines the optimum process scheme of preparation expelling parasite regenerated celulose fibre, can developHave the expelling parasite regenerated celulose fibre of persistent high efficiency, expelling parasite regenerated celulose fibre prepared by the present invention is to carry out all kinds of expelling parasitesThe basis of the exploitation of fabric. The expelling parasite textile that utilizes this expelling parasite regenerated celulose fibre exploitation, can replace by rear arrangementThe expelling parasite textile of exploitation, greatly reduces cost and the pollution to environment like this, and the reality that improves expelling parasite type textile shouldBy value.
Insect-repellent fiber material of the present invention has important meaning mainly to comprise the following aspects:
(1) the expelling parasite regenerated celulose fibre of preparing is the basis of carrying out all kinds of Worm-expelling fabric exploitations, due to insect-repellent fiberMaterial itself just possesses the required function for expelling pests of people, utilizes this material can directly develop expelling parasite textile, after can replacing and passing throughArrange exploitation expelling parasite textile, meanwhile, strengthened validity and the persistence of function for expelling pests, greatly reduce costs with to environmentPollute, improve the actual application value of expelling parasite textile.
(2) adopt natural expelling parasite Chinese medicine additive, environment is poisoned less and had no side effect, the expelling parasite regenerated fiber of preparationCellulose fiber is a kind of novel green fiber, can natural degradation, meet these themes of the times of environmental protection, and be a kind of promisingCellulosic fibre material.
(3) this technology also for exploitation other specific functionality textiles point the direction, as can utilize persimmon leaf have anti-oxidant,The pharmacological properties such as hemostasis, reducing blood lipid, taking persimmon leaf as raw material, adopt the production technology of this project, and preparation has the doctor of hemostatic functionUse material.
Brief description of the drawings
Fig. 1 is Chinese medicine pest repellant vitro antibacterial activity table described in the embodiment of the present invention;
Fig. 2 is Chinese medicine expelling parasite additive repelling effect table described in the embodiment of the present invention;
Fig. 3 is Chinese medicine expelling parasite additive site test results described in the embodiment of the present invention;
Fig. 4 is Chinese medicine fabric insect-repellent fiber preparation technology flow chart described in the embodiment of the present invention;
Fig. 5 is Chinese medicine fabric experiment anthelminthic effect table described in the embodiment of the present invention.
Detailed description of the invention
Describe embodiments of the present invention in detail below with reference to embodiment, whereby to how application technology hand of the present inventionSection solves technical problem, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Mint fibers characteristic: Compendium of Material Medica the 14 volume: " peppermint, cauline leaf smell is pungent, warm, nontoxic, cure mainly harmful wind woundCold, sweating bad odor trusted subordinate turgor, cholera, place food do not disappear, lower gas, sweating, have a bowel movement tired. " common peppermint has peppermintTea, menthol ointment, peppermint candy etc.
Mint fibers herbaceous plant concept, spinning property, product applicability that feel is smooth, good are wide.
Mint fibers function: the natural harmless antibiotic effect of mint fibers, wash after 50 times, still antibacterial higher than countryStandard. And possesses the natural cool feeling of mint fibers.
Mint fibers antibiotic facing material of the present invention, takes from naturally, is dissolved in naturally, and injects in the spinning stage, lastingProperty strong, and cost is lower, technique is relatively simple, is applicable to ruck consumption.
The natural peppermint of the present invention's " mint fibers " raw material abstraction, for serious pollution feelings of antibiotic facing material complex process in the industryCondition has played brand-new pioneering contribution, and energy-saving and emission-reduction environmental protection has been had to very large contribution.
The traditional production method of regenerated celulose fibre mainly contains two kinds of xanthates method and Fibre with Copper Ammonia Solutions. XanthatesBe a kind of solvent that is used as the earliest dissolving cellulos, utilize this solvent to be mainly used in viscose rayon or Cellophane (match LuoThe cellophane) production of fiber, present stage, most of cellulose products were mostly to utilize this explained hereafter. Xanthates method dissolving cellulosBe a complex process that comprises chemical reaction, its dissolution mechanism is first cellulose highly basic to be processed and generated alkali cellulose,React and obtain sodium cellulose xanghate with carbon disulfide again, be then dissolved in NaOH, when spinning solution is extruded,Intermediate compound is converted into cellulose again, can make viscose rayon. Utilize the major defect of this cellulose solvent exploitation fiberCan emit CS in whole production process2And H2The toxic gases such as S, pollute empty G&W, and this is to hinder for a long timeHinder the biggest obstacle of this cellulose dissolution development. Utilizing copper ammon solution to produce regenerated celulose fibre is that another is traditionalProduction method, except copper ammon solution, cupri-ethylene diamine solution also can be for dissolving cellulos, with copper ammon solution solution principle oneCause. Cuprammonium complex ion in solution can form cellulose derivative with cellulose, and then makes cellulose dissolution, its solution moltenSolution property is relevant with the degree of polymerization and solution temperature that the concentration of cuprammonium complex ion, cellulose slurry are moored.
Novel cellulose production technology mainly contains: cellulose carbamate (claiming again CC) method, N-methylmorpholine-N-oxygenThe production technologies such as compound (NMMO) method and ionic liquid.
A. cellulose carbamate (CC) method: this spinning production technology is the base that synthesizes with cellulose carbamatePlinth, the cellulose production new technology growing up gradually. Concrete technology flow process is first to use saturated aqueous solution of urea pre-to celluloseProcess, then at high temperature react and be converted into carbaminate, be finally dissolved in NaOH solution, form spinning solution.
B.N-methyl morpholine-N-oxide (NMMO) method: utilize N-methylmorpholine-N-oxide (NMMO) to dissolve fiberElement, carries out cellulosic production, and NMMO is considered to the most promising organic solvent, has successfully developed with this solution spinningLyocell fiber. Find NMMO dissolving cellulos well people such as nineteen thirty-nine Graenacher, obtain fibroblast, one-tenthThe cellulose solution that film properties is good. NMMO is a kind of aliphatic cyclic tertiary amine oxide, syntheti c route be first diethylene glycol (DEG) withAmmonia react generates morpholine, then through methylating and H2O2The dissolution mechanism that oxidation obtains NMMO.NMMO dissolving cellulos is celluloseInner hydrogen bond is replaced by the hydrogen bond between solvent molecule and cellulosic molecule and dissolves. In NMMO, contain the strong of N-O keyPolarity, oxygen atom can form hydrogen bond with the hydroxyl of cellulose inside. First NMMO has an effect with the fiber of noncrystalline domain, soAfter progressively enter cellulosic crystal region, and then destroyed cellulosic supramolecular structure, finally make cellulose obtain fullyDissolving. It has intensity height and good dimensional stability to utilize this cellulose dissolution successfully to develop Lyocell fiber, isThe green fiber of 21 century. But this cellulose solvent price compared with high, byproduct of reaction is many, dissolution conditions be difficult to control andReclaim the defects such as difficulty, need to further study, just can make this cellulose dissolution reach widely and utilize.
C. ionic liquid method: refer in temperature lower than 100 DEG C of liquid that formed by ion that are in a liquid state. Having of it and otherCellulose difference does not have electroneutral molecule in ionic liquid, is all anion and cation.
Ionic liquid not only can dissolving cellulos, also can dissolve most of inorganic matters, organic matter and macromolecule simultaneouslyMaterial. Ionic liquid also can be used as the catalyst of some reaction. Because ionic liquid can not form steam, therefore in production processIn can not produce pernicious gas, avoided in use causing environmental pollution, be called as eco-friendly green solvent. AlwaysThe advantages such as ordorless, pollution-free, the difficult combustion of body ionic liquid, easily separated and easy recovery can repeated multiple timesly recycle,Make it become the ideal substitute of traditional volatile organic solvent. Ionic liquid nitro ethamine (EtNNO3) is the earliest by WaldenSynthetic in 1914; Then in 1948, Hurley waited the fluid that contains N-ethylpyridine cation.
Present stage, also little to the research of insect-repellent fiber, expelling parasite regenerated celulose fibre is still belonged to the first at home and abroad. ThisInvention mainly comprises the following aspects:
(1) pre-treatment of mint fibers element and other raw material, comprises that cellulose is purified and activation;
(2) dissolubility, the cellulose copper ammon solution rheological property of mint fibers in copper ammon solution;
(3) preparation method of expelling parasite regenerated celulose fibre, mainly comprises coagulating bath to nascent insect-repellent fiber structure and drawsStretch impact, the lifting of tensile fiber performance etc. of performance;
(4) structure of expelling parasite regenerated celulose fibre and physical and mechanical properties, disinsectization performance.
The present invention, taking mint fibers and cellulose pulp as raw material, utilizes Fibre with Copper Ammonia Solution, adopts wet spinning preparation to driveWorm regenerated celulose fibre. The expelling parasite regenerated celulose fibre of research and development is one of important source material of exploitation expelling parasite textile.
Cellulosic purification is exactly to make cellulose and wax, pectin and lignin separation, obtains cellulose purityHigh product. Cellulosic purification mainly contains chemical method and the large class of bioanalysis two. Bioanalysis is mainly to utilize corresponding enzyme to make a return journeyCellulosic purification is carried out in the removal of impurity, and chemical method is more a kind of cellulose purification means that use at present.
Mint fibers is except being rich in cellulose, and the compositions such as hemicellulose, lignin, pectin, wax also account for significant proportion.In mint fibers, hemicellulose level is larger, and content is greatly about 22% left and right, and its content is higher, and the wax of mint fibers on average containsAmount 8.72%, is greater than common native cellulose fibre as flax, cotton and kapok etc., carry out the exploitation of mint fibers, waxRemove particularly importantly, the pectin content of mint fibers is about 1.23%, substantially suitable with the pectin content of cotton fiber. In view of peppermintThe cellulose purity of fiber is lower, is necessary before use to carry out cellulose purification.
1, the purification of mint fibers element:
(1) pre-treatment of raw material:
The peppermint herb being collected is dried in vacuum drying oven, utilize high speed medicinal herb grinder to pulverize, obtain thinLotus cellulose powder.
(2) removal of pectin and wax:
Aforementioned mint fibers powder is washed several times, carried out suction filtration, in the process of suction filtration, ceaselessly use ethanol and benzeneMixture repeatedly washs, and then in 12% ammonium oxalate, soaks 4-5 hour, after 3 washing suction filtrations, again dries, and has just obtainedGet rid of the product of wax and pectin.
(3) other appendicular removals:
The product of removing wax and pectin is utilized respectively to the sodium acid carbonate circulation immersion, clear of 5% dilute sulfuric acid and 10%Wash 3 times, each 2-3 hour, removes lignin and hemicellulose, and then carries out suction filtration washing, by sample drying, has just obtainedPure cellulose product.
2, cellulosic activation
Cellulosic activation is one of key link of preparing insect-repellent fiber, and the quality of activation is directly connected to spinning solutionQuality, and then affect the quality of fiber product. Fiber activation can be divided into physical method activation and chemical method activation. Physics sideMethod activation mainly contains the technological means such as steam explosion technology, high energy electron irradiation and microwave and ultrasound processing, physical methodActivation can, under the prerequisite that meets requirement of experiment, reduce the use of chemicals, avoids to environment its techniqueFlow process is also short, and present stage adopts physically activated method mostly. The cellulosic reagent of chemical activation mainly contains: NaOH, liquefied ammonia,The system of acetone and various dissimilar mixed solvent compositions.
The invention provides 2 kinds of different activation methods:
(1) alkali activation: take the mint fibers 50Kg after purification, be placed in the container place that fills 11%-14% NaOHReason 6-8 hour, then filters, washes, until water lotion approaches pH value neutrality, takes out the fiber after cleaning, and dries by vacuumCase is dried to constant weight, is placed in drier cooling, for subsequent use.
(2) acid activation: take the mint fibers 50Kg after purification, be placed in the container that fills 10%-13% dilute sulfuric acid and process6-8 hour, then filters, washes, until water lotion approaches pH value neutrality, takes out the fiber after cleaning, and uses vacuum drying ovenDry to constant weight, be placed in drier cooling, for subsequent use.
3, cellulose is in the dissolving of copper ammon solution
The present invention adopts copper ammon solution as cellulose solvent, carries out the production of insect-repellent fiber. Utilize copper ammon solution to dissolveRegenerated celulose fibre prepared by fiber, fiber is softly smooth, close with Real silk properties, and hygroscopicity is strong, good permeability, intensityHeight, drapability is good, and owing to using wet spinning, fiber cross section is sub-circular, without skin-core structure, has natural fiber institute toolAll advantages that have, can not produce toxic gas after burning, environmental-protecting performance is good.
In copper-bath, add excessive sodium hydroxide solution, by gained Cu (OH)2Precipitation suction filtration, wash severalInferior, to get rid of Na+With SO4 2-Impact, then add slowly concentrated ammonia liquor that Kocide SD precipitation is just disappeared, obtained darkBlue copper ammon solution. Concentrated ammonia liquor concentration used is that between 25-28%, density is about 0.91g/ml, and amount of substance concentration is about13.3mol·L-1. In the ammoniacal liquor of 100L, dissolve Cu (OH)2Quality be slightly larger than 1Kg. By mint fibers and cotton after activationCellulosic mixture (wherein the mass ratio of mint fibers and cotton fiber is 1:10 ~ 1:5), is dissolved in aforementioned at 40-46 DEG CPreparation is dissolved in copper ammon solution, forms 5 ~ 10% cellulose stoste. Afterwards, add therein the Chinese medicine of the present invention of 2%-10%Expelling parasite additive.
Vast territory and abundant resources in China, abounds with various natural Chinese medicinal herb. Chinese herbal medicine is traditional culture marrow. By traditional Chinese medicine theory withModern science and technology combines, and by various modern techniques such as refinement, extractions, Chinese herbal medicine elite is used for to mosquito repellent product series, spyResearch and develop herbal type high-quality and driven kill mosquito product, adopted multiple extracted form natural plant composition, naturally gentle, can alleviate rapidly mosquitoDiscomfort after biting, the pure gentleness of product, non-stimulated, the safer care of skin of giving adult. As brand-new deinsectization underwearQuite popular in America and Europe, Japan and other countries and area. Research shows, because invention Chinese medicine expelling parasite additive has unique releasingPlaying function, outside decapacitation mosquito repellent, also has the peculiar smell of eliminating, inspires enthusiasm, the advantage such as antibiotic health care, has before good applicationScape.
Under laboratory condition, the present invention observes repelling effect of the present invention with aedes albopictus and culex. KnotFruit demonstration, Chinese medicine mosquito repellent additive of the present invention is to having certain repellent effect for examination mosquito, and its juice can effectively prevent mosquitoSting, and in confined conditions multiple mosquito is also had to stronger smoked kill effect.
Rhizoma atractylodis are pungent, bitter, temperature. Return spleen, stomach, Liver Channel. Function cures mainly: drying damp and strengthening spleen, and expelling wind and clearing away cold, improving eyesight. For gastral cavity abdominal distensionFull, the oedema of having loose bowels, beriberi Wei lame, arthralgia due to wind-dampness, anemofrigid cold, yctalopia. Main the spleen and stomach being stranded by dampness; Burnout is had a liking for sleeping; Born of the same parents' ruffian abdominal distension; FoodWish is depressed; Tell and have loose bowels; Phlegm and retained fluid; Wet swollen; Illness that has not attacked the vital organs of the human body folder is wet; The heavy pain of body; Bi Zheng warm nature; Podomere is ached and is being weighed; Impotence folds in a garment. Rhizoma atractylodis toolHave drying damp and strengthening spleen, effect of wines used as antirheumatic. Cure mainly damp retention in middle-jiao, wind-cold-dampness arthralgia, pin swelling and pain in knee, impotence is soft unable, night blindness yctalopia. " stoneCassia tora capsule " day: " can stomach invigorating pacify spleen, all wet swollen non-these can not remove. " Compendium of Material Medica says: " control wet phlegm and stay drink ... and spleen wet underStream, under turbid drop band, the sliding intestines wind that rushes down. " " Tang materia medica " claim that it can " diuresis ".
Bletilla striata property hardship, sweet, puckery, is slightly cold. Return lung, liver, stomach warp. Function cures mainly astringing to arrest bleeding, detumescence and promoting granulation. Tell for hemoptysisBlood, traumatism and bleeding, sore swollen toxin, chapped skin; Pulmonary tuberculosis hemoptysis, ulcer haemorrhage. Shennong's Herbal: " main carbuncle is swollen, evilSore, lose subcutaneous ulcer, the dead flesh of impairment of yin, perverse trend in stomach "; Compendium of Material Medica: " smell (root) is bitter, flat, nontoxic.
The flower bud of lily magnolia is warm in nature, the pungent micro-hardship of taste. Gui Jing attaches to the lung and stomach meridians. Dispersing wind and cold, clearing the nasal passage. For anemofrigid headache, nasal obstruction, nasosinusitis,Turbid nasal discharge. " herbal classic ": main the five internal organs health fever and chills, public attention cerebralgia, face acid anhydride. " not Lu ": expelling pathogenic factors from muscles and skin in temperature, sharp nine orifices, logical nasal obstruction, tearsGo out, control edema of the face and draw dentalgia, vertigo, body several as on car and boat person. Raw beard and hair, goes white worm. " property of medicine opinion ": can control the acid anhydride of looking unfamiliar.Face fat use, key light China.
The root of Chinese wild ginger, Chinese medicine name, cures mainly: dispel the wind, loose cold, row water, has one's ideas straightened out. Control air-cooled headache, nasosinusitis, dentalgia, phlegm and retained fluid is coughed contrary, windPain of dampness syndrome. All herbal medicine, with being antipyretic, diuresis, analgesia, sedative. Control headache, the effect of have sweating, eliminating the phlegm. Exterior syndrome due to wind-cold; HeadBitterly, toothache; Arthralgia due to wind-dampness; Phlegm and retained fluid is coughed and is breathed heavily; Nasal obstruction; Nasosinusitis; Aphtha. Refrigeration function Herba Asari volatile oil gavages many reasons as temperatureAcupuncture manipulation, tetrahydrochysene beta-naphthylamine, typhoid fever, the caused rabbit experiment heat pyrexia of paratyphoid polyvalent vaccine have obvious refrigeration function, rightRat fever due to brewer's yeast also has obvious solution thermal effect. Can also reduce the body temperature of normal rat.
Cloves: enter liver, kidney two warps. Function cures mainly eliminate indigestion, and screen disappears. Control hernia lump in the abdomen, disease addiction, order screen, the triangular mass of mucous membrane growing from the inner corner of the eye, carious tooth. Treat order pain,Certainly carbuncle furuncle, woman is with down, drowns unfavorable, except hernia lump in the abdomen. " daily book on Chinese herbal medicine ": " remove freckle on face, acne. "
Fish pelargonium Latin formal name used at school PelargoniumhortorumBailey. smell is sweet and slightly heavy, a little as rose, againSlightly as peppermint. Historical clinography: be once used to treat cholera and bone is injured, and also had the effect of exorcising a demon. Effect: hemostasis,Vasoconstriction, asthma, liver and expelling toxin, gall stone, kidney toxin expelling, kidney stone, diuresis, DOMS, Oily, aging skin is livedChange, bleb, ochrodermia, fat-reducing, promotes to scab, eczema, the sunburn of burning, tinea, menstruation has some setbacks, and engorgement of breasts inflammation, alleviates sorrowYu Buan, mends body, and deodorizing is antibacterial, sterilization. and fish pelargonium is neural tonic, can put down and comfort anxiety, dejected, can also improve feelingsThread. Allow mental recovery balance, and because it also can affect adrenal cortex, therefore it can relieve pressure.
Peppermint is one of Chinese conventional Chinese medicine. It is pungent cool property sweating antipyretic medicine, controls influenza, headache, hot eyes, bodyHeat, throat, the gum disease such as swell and ache. Place is with controlling neuralgia, pruitus, fash and eczema etc. The peppermint of light friend Greenhouse Fruit PickingIt is again the fresh vegetable on dining table in the Spring Festival. Clearly good to eat. Usually with peppermint for tea, improving eyesight clears away heart-fire. Peppermint has medical and edible dualFunction, mainly edible position is stem and leaf, the clothes of also can squeezing the juice. On edible, peppermint both can be used as flavor enhancement, can make again spices,Also can join wine, make tea etc. In every 100 grams of dried peppermints, 31.1 grams of 9.6 grams of moisture contents, 6.8 grams, protein and fibers, can provide870.7 the heat of kilojoule.
Radix zanthoxyli (formal name used at school: Zanthoxylumnitidum(Roxb.) DC.) root, stem, the leaf of Radix zanthoxyli be used as medicine. Can the loose stasis of bloodActive, the removing toxic substances of dispeling the wind. All can excavate the whole year, cleans, and section or section, dry. Aubergine when Follicle radish fruit is ripe, has thick gland point,The short beak of the positive tool in top. There is promoting qi circulation and relieving pain, the effects such as promoting blood circulation to remove blood stasis. Can be used for traumatic injury, arthralgia due to wind-dampness, stomachache, toothache, poisonous snakeBite etc. Leaf and pericarp can be carried aromatic oil; Seed oil is for soap system.
Kuh-seng, Chinese medicine name. For the dry root of legume kuh-seng, spring, Qiu Erji excavate, and remove root head and little supporting root, washOnly, dry, or take advantage of fresh slices, dry. Its hardship, cold. There is heat-clearing and damp-drying drug, desinsection, the merit of diuresis. For hot dysentery, have blood in stool, jaundice urineClose, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy, controls trichomonas vaginitis outward.
Climbing groundsel (SenecioscandensBuch.-Ham.exD.Don), has another name called nine li of bright, Herba Senecionis Scandentis, chrysanthemumMother, Kowloon light, nine ridge light. Be a kind of Chinese herbal medicine, it is cold in nature, bitter, have clearing heat and detoxicating, improving eyesight, the effect such as antipruritic. Be used forAnemopyretic cold, red eye, swell pain, dysentery, skin eczema sore furuncle.
The pungent perfume (or spice) of kaempferia galamga gas, pungent, taste is sweet, pungent. , look white, pungent give off a strong fragrance person large, full taking sheet is as good. Nature and flavor andFunction is pungent, temperature. Return spleen, stomach warp. Warming middle-JIAO for eliminating dampness, promoting qi circulation and relieving pain. For chest abdomen crymodynia, cold-dampness is vomited and diarrhoea, bone sticking larynx, and toothache, falls and beatsSwell and ache etc.
Calamus: bitter, pungent, temperature. Reduce phlegm, have one's ideas straightened out, invigorating the spleen, dampness removing. For epilepsy, palpitate with fear forgetful, obnubilation, humidity hysteresis ruffianSwollen, dysentery, rheumatalgia pain, the carbuncle scabies that swells. Its flower of calamus, stem aromatic flavour, have have one's ideas straightened out, eliminate the phlegm, effect of loose wind, canThe epidemic disease of dispelling intelligence development, improve the health. The successive dynasties classic of TCM is the medicine using calamus rhizome as the wide chest of intelligence development, hearing-improing and eyesight improving, clearing damp removing toxic substances all.
The tarragon prevention pestilence history of existing several thousand, Chinese herbal medicine can be gathered materials on the spot, and the pharmacological research of modern medicineShow that tarragon is a kind of medicine of broad-spectrum antibacterial antiviral, it has inhibition and lethal effect to a lot of virus and bacterium, to exhalingDesorption system disease has certain preventive and therapeutic effect. Tarragon taste is pungent, bitter, warm in nature, nontoxic; Return spleen, liver, kidney channel; Fragrance temperature is loose, and can rise canFall. there is warming channel for arresting bleeding, eliminating cold to stop pain, effect of wet down desinsection. cure mainly irregular menstruation, dysmenorrhoea, fertility, fetal irritability,Trusted subordinate's crymodynia, spits blood, bleeding from five sense organs or subcutaneous tissue, and spitting of blood, has blood in stool, uterine bleeding, gestation hemorrhage, the protracted dysentery of having loose bowels, under band, eczema, mange, carbuncle is swollen, hemorrhoid.Moxibustion treatment all kinds of diseases and ailments.
Borneol has another name called sheet brain, tangerine sheet, L-Borneol, kapur, MEIHUA BINGPIAN, Dipterocarpus pilosus, plum blossom brain, borneol brain, Mei Bing etc.,Also be recrystallized and obtain through steam distillation by composite family Blumea balsamifera cauline leaf or canella borneol camphor tree branches and leaves. Also useful turpentine oil warpA series of chemical method technique and obtaining. It can be used for closing card coma, for red eye, swell pain, larynx numbness aphtha, swell and ache for sore, burstAfter do not hold back etc.
Windproof Chinese medicine name. Another name copper rue, Hui Yun, return grass, hundred, hundred kinds. Windproof Gen Kesheng uses. Taste is pungent, sweet, and property is micro-Temperature. Expel pathogenic wind from the body surface, removing dampness to relieve pain, only effect of convulsion. For diseases caused by external factors illness that has not attacked the vital organs of the human body, rubella itch, arthralgia due to wind-dampness, lockjaw just, spleenEmpty wet Sheng. Compendium of Material Medica: " wind as 36, goes part of the body cavity above the diaphragm housing the heart and lungs ailment said due to cold or exposure, the stagnant gas of the head, and channels and collaterals stay wet, all over the body pain all over the joints. Except wind goesWet elixir. " " medicine class method resembles ": " control wind general. Purging the lung of pathogenic fire is real, and stagnant gas in the loose head, except part of the body cavity above the diaphragm housing the heart and lungs heresy. "
Its nature and flavor acrid, sweet, warm of cassia twig, enter lung, the heart, urinary bladder channel, are to cure mainly the conventional drugs for dispelling internal cold of interior cold, have complement sun,Effect of promoting blood circulation, warming spleen and stomach, normal and filling liver kidney medicine, the medicine compatibility that fills blood, treat the insufficiency of the kidney yang, the Yang-function insufficiency of kidneyzang, the cold weak pulse of limb,With other drugs for dispelling internal cold compatibility treatment coldness and pain in the epigastrium, arthritis pain in the back, there is the effect of obvious analgesia and anti-cancer and cancer-preventing. Existing eachKind of wind dispelling oils medicine all contains oil of bay composition as cooling ointment, rheumatism wet goods.
Chinese cassia tree complement sun, warming spleen and stomach, removing internal cold, promoting blood circulation. Control the Yang-function insufficiency of kidneyzang, the cold weak pulse of limb, yang depletion collapse, stomachache is let outRush down, the cold hernia globefish that runs quickly, waist knee crymodynia, through closing abdominal mass, cloudy subcutaneous ulcer, streamer, and empty sun is more floating, heat in the upper and cold in the lower. " herbal classic ": Your Majesty's gas is coughedContrary, knot gas larynx numbness is told suction, sharp joint, tonifying middle-Jiao and Qi. " not Lu ": main pained, side of body wind, hypochondriac pain, warm muscle, promotes blood circulation, only tired, perspire.In main temperature, benefitting liver and lung gas, trusted subordinate's fever and chills, cold disease, choleraic myospasm, headache, pain in the back, only saliva, cough ， Bi Weng: can have an abortion, hard boneJoint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, and nothing institute is feared.
The rhizoma cyperi Xie Yu that regulates the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive. The main distending pain in hypochondrium; Spargosis is educated; Hernia pain; Irregular menstruation; Gastral cavity abdomenThe full pain of ruffian; Belch acid regurgitation, the evil of vomitting; Dysmenorrhea; Under uterine bleeding band; Fetal irritability. For stagnation of QI due to depression of the liver, chest, the side of body, gastral cavity abdominal distensionBitterly, indigestion, chest gastral cavity ruffian is vexed, cold hernia stomachache, swollen breasts, irregular menstruation, through closing dysmenorrhoea.
Eupatorium: experience summer-heat and damp; Fever and chills headache; In moistening, accumulate; Gastral cavity ruffian is not hungry; N and V; Sweet greasy in mouthful; Disappear truly. Be used forTurbi damp obstructing in middle-JIAO, the gastral cavity ruffian evil of vomitting, sweet greasy in mouthful, halitosis, polysialia, summer-heat and damp table disease, alliteration is uncomfortable in chest. " herbal classic ": main dredging water passages, kills legendary venomous insectPoison. " Chinese medicinal herbal ": deliver clearing damp, and middleization is turbid. Control summer-heat headache, lossless heating, abdomen uncomfortable in chest is full, sweet greasy in mouthful, halitosis. " guiding principleOrder ": subduing inflammation, adjust menstruation. " modern Practical Chinese medicinal ": be armaticity stomach invigorating, sweating, diuretics. Be used for emitting cold headache, nosePlug, nervous headache, infectiousness pyreticosis, stomachache, waist nephralgia, calculus etc.
Specific embodiment 1
By rhizoma atractylodis 1000g, peppermint 1000g, Radix zanthoxyli 1000g, kuh-seng 1000g, climbing groundsel 1000g, kaempferia galamga 1000g, ChangPu 1000g, tarragon 1000g, borneol 1000g, flower bud of lily magnolia 1000g, root of Chinese wild ginger 1000g, cloves 1000g, windproof 1000g, cassia twig1000g, Chinese cassia tree 1000g, rhizoma cyperi 1000g, bletilla striata 1000g, eupatorium 1000g, fish pelargonium 1000g, is vaporized into crystallization by the way of distillation,Grinding and sieving, the dusting cover of 120-150, stand-by excessively, as component 1; Bulk drug residue after vaporization is soaked, and heating is boiledBoil 3 times, each 1-2 hour, filters, and filtrate is for subsequent use; By merging in the filtrate suction reduced pressure concentration tank of latter 3 times, be evaporated toRelative density is 1.20, the medicinal extract that temperature to 60 is DEG C-70 DEG C; Become component 2, blending ingredients 1 and component 2, add and go out with ultraviolet rayBacterium is stand-by.
Specific embodiment 2
By rhizoma atractylodis 1200g, peppermint 1200g, Radix zanthoxyli 1300g, kuh-seng 1200g, climbing groundsel 1200g, kaempferia galamga 1200g, ChangPu 1200g, tarragon 1100g, borneol 1200g, flower bud of lily magnolia 1200g, root of Chinese wild ginger 1200g, cloves 1200g, windproof 1200g, cassia twig1200g, Chinese cassia tree 1100g, rhizoma cyperi 1100g, bletilla striata 1200g, eupatorium 1100g, windproof 1100g, camphor 1100g, uses way of distillation vapourChange into crystallization, grinding and sieving, the dusting cover of 120-150, stand-by excessively, as component 1; The bulk drug residue that vaporization was extracted addsEnter in the ethanol that 5-10 doubly measures and soak 1-2 hour, heating is extracted 2 times, and each 1-2 hour, merges extract, after leaving standstill, removes supernatantLiquid, then 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, ultrafiltrate reduced pressure concentration phase1.36 medicinal extract when density is 80 DEG C, stand for standby use, becomes component 1. The dregs of a decoction of the bulk drug that above-mentioned alcohol extract is crossed add 10Times water gaging, heating and refluxing extraction 2 times, each 1～2 hour, No. 2 extracts are merged and left standstill, become component 2. By component 1 and groupPoints 2 merging, adds with ultraviolet disinfection stand-by.
Specific embodiment 3
By rhizoma atractylodis 1300g, peppermint 1200g, Radix zanthoxyli 1300g, kuh-seng 1200g, climbing groundsel 1100g, kaempferia galamga 1200g, ChangPu 1300g, tarragon 1400g, borneol 1200g, flower bud of lily magnolia 1200g, root of Chinese wild ginger 1200g, cloves 1200g, windproof 1200g, cassia twig1200g, Chinese cassia tree 1400g, rhizoma cyperi 1300g, bletilla striata 1200g, eupatorium 1100g, windproof 1300g, camphor 1100g, uses way of distillation vapourChange into crystallization, grinding and sieving, the dusting cover of 120-150, stand-by excessively, as component 1, the dregs of a decoction of the bulk drug that vaporization was extractedSoak 1 hour; Put boiling secondary in multi-function extractor; Add up for the first time the water of 10 times of amounts of medicinal material, decoction 1.5～2 hours, get decocting liquid, filter; Add for the second time the water of 7 times of amounts of total amount, decoct 1～1.2 hour, get twice decocting liquid and mix, filter; WillThe filtrate of filtering is inserted in economic benefits and social benefits vacuum concentrator, and the concentrate that while being concentrated into 90 DEG C, relative density is 1.05, sets to 0～5 DEG C lowTemperature refrigeration 24 hours; Refrigeration liquid is added to 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, denseBe reduced to every 1ml containing 0.1g crude drug amount, as component 2, by the merging of component 1 and component 2, add with ultraviolet disinfection stand-by.
Pharmacology toxicity test
Antibacterial tests of the present invention
Experiment material
1, animal subject: Kunming mouse, 18-22g, male and female half and half; Instar chicken embryo on the 9th. 2, bacterium and virus: bacterial isolatesBe clinical separation strain, totally 97 strains; Flu virus FM1 strain. 3, plate: MH culture medium; Streptococcus pneumoniaAdopt blood meida, in MH culture medium, add 5% defiber sheep blood to make; Haemophilus influenzae adopts chocolate cultivationBase.
2, In vitro Bactericidal Experiments
1, the mensuration of external minimum inhibitory concentration (MIC)
(1) experimental technique: be subject to reagent (the present invention) to extract medicinal extract sterile saline and be diluted to following concentration gradient,1600,800,400,200,100,50,25,12.5,6.25,3.13 (mg/ml), draw respectively 1.5ml to aseptic plateIn, then add the sterilizing MH culture medium in 55 DEG C of water-baths of 13.5ml constant temperature, mix rear cooling for subsequent use. The dull and stereotyped Chinese traditional medicine of each medicineUltimate density be 160,80,40,20,10,5,2.5,1.25,0.625,0.313 (mg/ml). Establish blank group simultaneously. WillThe test organisms of cultivating 8-12h is diluted to desired concn (being generally 107CFU/ml) with sterile saline, adopts multiple spot inoculationInstrument is connected to the medicine flat board of variable concentrations, and inoculum concentration is about 104～105CFU. Test organisms was in 37 DEG C of constant temperature culture 24 hoursObserved result, and record MIC value.
(2) experimental result
In vitro Bactericidal Experiments result shows (seeing Fig. 1), and Grain-positive and the Grain-negative of medicine to the infection of the upper respiratory tract facesBed pathogenic bacteria are all inhibited, wherein to staphylococcus aureus, MRSE, streptococcus pneumonia, bloodthirsty influenzaThe MIC50 of bacillus, Klebsiella Pneumoniae, Escherichia coli and Pseudomonas aeruginosa is respectively 10,20,20,2.5,40,20 and 10mg/Ml, MIC90 is respectively 80,40,80,20,160,40 and 160mg/ml.
Acute toxicity testing data
1, experimental technique
Guinea pig back backbone both sides are evenly coated hair remover, make approximately 40 square centimeters of unhairing scopes. Clean hair removerReturn cage to observe 24 hours, every group of cavy is coated with respectively the present invention 0.2,0.4 and 0.8ml, respectively containing crude drug 92mg, 184mg and368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment finishes, cavy is put to death to the heart, liver, kidney and de-Fur skin does pathological examination.
2, result
Above-mentioned three groups of medication cavy trunks depilation district, having no local skin has oedema, hyperemia, erythema, blutpunkte and ulcer.Medication group cavy chroma of hair, ingest, the control group no significant difference such as four limbs activity, histopathologic examination, the administration group heart,Liver, kidney and depilation skin with contrast more also no significant difference of word.
Results suggest, the present invention, without local irritant effect, also has no general toxicity performance. Show that the present invention uses safety.
Long term toxicity test data
1, experimental technique
Become 4 groups, 15 every group by random cavy part. In guinea pig back backbone both sides, hair remover is evenly coated, made it de-Approximately 40 square centimeters of hair scopes. Clean hair remover, observe every group of cavy after 24 hours and be coated with respectively eye cream 0.2,0.4 and of the present invention0.8ml, respectively containing crude drug 92,184 and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, and continuous 30 days, observation cavyOrdinary circumstance, experiment finishes rear execution animal and carries out hematology, blood biochemical and pathological examination.
2, result
Above-mentioned three groups of medication cavy trunk unhairing districts, having no local skin has oedema, hyperemia, erythema, blutpunkte and ulcer.Medication group and control animals chroma of hair, ingest, the control group no significant difference such as four limbs activity, blood biochemistry checking, medicationGroup and control group are all in normal range (NR). Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious diseaseBecome. Prompting, long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ. Result of the test tableBright: experiment safety of the present invention.
Pharmacology test
Object: the repelling effect of testing dress material herbal medicine immersion liquid of the present invention. The author verifies and comments by 4 groupsValency.
1 materials and methods
1.1 test samples and equipment: prepare herbal medicine immersion liquid of the present invention by the method for embodiment 2. Column type glass mosquitoCage (bottleneck 30cm, high 30cm), puts 90 of examination mosquitos in a suitable place to breed; Airtight good glass jar (60cm × 30cm × 35cm), inPortion separates with gauze, and 90 of examination mosquitos are put in left side; Mosquito net 3 pushes up (2MM × 1M × 1.5).
1.2 aedes albopictus (Aedesalbopictus) and the culexs of not sucking blood for the rear 4～5d of examination mosquito emergence(Culex.spp) female mosquito, is the common people of disturbing mosquito kind.
1.3 experimental condition temperature (26 ± 1) DEG C, relative humidity (60 ± 5) %, tests the mosquito in 19:00～21:00Carry out the worm peak period of sucking blood.
1.4 test method
1.4.1 effect of the present invention: test is prepared soak of the present invention according to the method for embodiment 2. Select 3 people in testThe different time on the same day, by everyone 1ML liquid measure, is evenly coated the skin exposed section of left hand the back of the hand 4cm × 4cm, with right hand handIn contrast, the back of the hand remainder all tightly covers the back of the body. When test, successively the right hand and left hand are stretched into 5min in glass mosquito cage,Observe and record the mosquito number of times that comes to stop and suck blood, calculate effective protecting time and protective rate. Effective protecting time is with nothingMosquito comes to stop the maximum duration of sucking blood and calculates.
Protective rate (%)=right hand bite by mosquitos number of times-left hand bite by mosquitos number of times/right hand bite by mosquitos number of times × 100
1.4.2 repellency test stretches into both hands the right-hand part of glass jar, puts into the liquid of the present invention of some simultaneously,Put into front bottle water spray, in 5min, record and rest in or collide the mosquito number of times on gauze. Every group is repeated 3 times, calculates protectionRate.
1.4.3 smoked kill is tested in 250ml conical flask, every bottled 10 of mosquitos that enter to try. Get respectively fresh liquid of the present invention5ml, 10ml, 15ml grind in mortar, then put into conical flask, closely seal with preservative film, and every group is repeated 3 times, with speckling withThe absorbent cotton of distilled water in contrast. Observe and record examination mosquito all by the lethal time of smoked kill.
1.4.4 outdoor test is selected intensive, the quiet calm place of mosquito, in propping at dusk 3 top mosquito nets, mosquito net bottomApart from ground 20cm, in two groups of mosquito nets, put into respectively 2 basin medicinal extract of the present invention, another 1 top is blank group, when test, needsTo spraying water in tent. Before 19:00, enter mosquito net by 1 people respectively, later l9:00～2l:00 every 0.5h observe and record intoEnter the mosquito number of times of mosquito net, calculate protective rate.
2 results and analysis
As seen from Figure 2, the present invention has good repellent effect, effective protecting time to mosquito to 2.1 juice repelling effectsIn 40min left and right, in 1.5h, still keep higher protective rate simultaneously.
The present invention also has stronger repellent action to mosquito, and a small amount of liquid can be achieved good results, and along with liquidThe increase protective rate of quantity significantly improves, and rises to more than 90% to protective rate after 10ml, also finds that now trying mosquito keeps away in testThe distance of opening is in 10cm.
2.3 smoked kill test effects try mosquito restlessness immediately after people's conical flask is put in the present invention, occur dead after 5minDie. And smoked kill time and the quality of the present invention of examination mosquito are negative correlation, and it is all lethal that 15ml can make mosquito within the shortest time.
2.4 outdoor mosquito nets tests are carried out outdoor test with 2 basin the present invention, each time period of 19:00～21:00,2 basins thisBright average 55.96% the protective rate that reaches, it is average 77.49% that 4 basin protective rates rise to, and visible the present invention is at outdoor skySpacious place has preferably repellent effect to mosquito, and after increasing its quantity, repelling effect can significantly improve (seeing Fig. 3).
Quite popular in America and Europe, Japan and other countries and area as brand-new deinsectization underwear. Much research shows, due toThis underwear has unique release function, outside decapacitation mosquito repellent, also has the peculiar smell of eliminating, inspires enthusiasm, eases off the pressure, antibacterialThe advantages such as health care, have good application prospect.
Under laboratory condition, we observe the repelling effect of the clean vanilla of mosquito with aedes albopictus and culex. KnotFruit demonstration, the present invention is to having certain repellent effect for examination mosquito, and its juice can effectively prevent bite by mosquitos, and closeClose under condition multiple mosquito is also had to stronger smoked kill effect. In test, find that the selection in place and correct using method areThe present invention receives the prerequisite of applications well effect.
4, spinning
Spinning is extruded spinning solution continuously and uniformly exactly under certain pressure from spinning head or spinneret hole,Form stoste thread, then in air, water or other coagulating baths, be solidified into the process of silk. According to shaping polymer natureDifference, spinning process is mainly divided into melt spinning process and the large class of solution spinning two, and solution spinning is not again according to coagulating bathWith being divided into dry spinning and wet spinning. The fusing point of every high polymer lower than its decomposition temperature, mostly adopts melt spinning process,The contrary solution spinning that adopts, because cellulose heat decomposition temperature is lower than fusion point temperature, can not directly carry out melt-processed, thereforeThe present invention adopts the wet spinning process in solution spinning to prepare insect-repellent fiber.
Wet spinning is by the spinning solution preparing, after filtration, after the operation such as deaeration, join in spinning still, at nitrogenUnder the effect of atmospheric pressure, spinning solution is extruded from spinning head, forms stoste thread, and thread directly enters coagulating bath, molten in stosteThere is a series of reaction with coagulating bath in agent, makes fibre forming. The structure of curing condition to as-spun fibre in wet spinning processMost important with the impact of performance.
(1) utilize light microscope to observe to cellulose course of dissolution in copper ammon solution, result display fibersFirst element occurs swelling in copper ammon solution, and then cellulose molecular chain constantly ruptures, and final cellulose dissolves completely.
(2) dissolubility of copper ammon solution is analyzed, found molten in copper ammon solution of cellulose after activatedXie Du significantly improves, and the solubility of cellulose in copper ammon solution is along with Cu simultaneously2+The rising of concentration and increasing, from economic interestsCu2+Content should be controlled between 18-20%; The solubility of the lower cellulose of temperature in copper ammon solution is higher, the present inventionBoth fixed temperature was 0 DEG C. The dissolving of cellulose in copper ammon solution is very fast, and approximately 2h left and right just can be dissolved completely.
(3) rheological property of cellulose copper ammon solution is studied. Find along with the rising of temperature, viscosity gradually underFall, therefore in the process of spinning, should suitably control the temperature of spinning solution, the viscosity of spinning solution is along with content of celluloseIncrease and increase, expelling parasite Chinese medicine additive content is larger in addition, and the viscosity of spinning solution is less, and the parameter adopting in experiment is to makeObtain spinning solution and keep low-temperature condition as far as possible, cellulosic content is in 7% left and right, and the content that adds expelling parasite Chinese medicine additive is 6%Left and right.
The 1000Kg copper ammon solution preparing is placed in to container, and the mint fibers after adding 10Kg activated adds simultaneouslyEnter the gossypin 50 ~ 100Kg after activation, to regulate the concentration of cellulose copper ammon solution, temperature is controlled at 0 DEG C of left and right, utilizesAgitator stirs after 2h, then adds 0.2 ~ 0.8Kg emulsifying agent, and 2 ~ 10Kg pest repellant of the present invention, then stirs a 2h left side at normal temperaturesThe right side, obtains spinning solution.
The emulsifying agent using in the present embodiment is peregal, English trade name: Peregal. AEOAlcoholEthoxylate. Molecular formula is: RO-(CH2CH2O）n-HR=C16-18N=9-30. There is good wet performance,And the performance such as there is good emulsification, dispersion, clean. AEO, leveling agent o has another name called paregal O, belong to non-fromSubtype surfactant, outward appearance is milky or ecru ointment shape, when molecular weight is higher, is solid shape and (can makes as requestedSlabbing solid), soluble in water, ethanol, ethylene glycol etc., have cloud point, and 1% aqueous ph value is neutral. Can be acidproof, alkaline-resisting, resistance to hardWater, heat-resisting, resistance to heavy metallic salt. Various dyestuffs are had to powerful level-dyeing property, slow metachromia, permeability, diffusivity, and when kiering, tool helps white silkPerformance, can be with various surfactants and dyestuff with molten use.
Idiographic flow be first spinning solution will be after filtration, after deaeration, under uniform temperature, nitrogen pressure, from 30 ×0.2mm spinning head is extruded, and then enters in diluted alkaline coagulating tank and carries out fibre forming, prepares as-spun fibre, then through overpickling,Stretching, wet heat setting, the post processing such as dry, obtained the good insect-repellent fiber of mechanical property.
Prepare the technological process of insect-repellent fiber element as shown in Figure 4, mainly comprise: the preparation of spinning solution, filtration, deaeration,Regeneration, pickling, washing, hot drawing-off.
In the spinning solution preparing, also exist a lot of undissolved mint fibers and other impurity, the work of filtrationWith being exactly to remove not molten cellulose and other impurity, if do not remove these impurity, when spinning solution sprays from spinneret orifice notCan form stable thread, the spinnability of solution declines, if impurity is too many, more can cause the obstruction of spinneret orifice, even fiber energyEnough shaping also may form weak link, and then affect the intensity of fiber in fibre structure; The process of filtering at spinning solutionIn, can produce a lot of bubbles, if before fibre forming, do not carry out deaeration processing, can affect the spinnability of spinning solution,Bring difficulty to spinning, when serious, even can cause fiber fracture of wire, the carrying out that allows to maintain spinning also can be caused fiber powerLearn the decline of performance, due to the existence of bubble, the fiber of spinning can cause cavity or not tight at some position, and then impact is fineThe overall quality of dimension; The spinning solution preparing is by the extruding of stream of nitrogen gas, and spinning solution is extruded and formed spinning by spinning headThread, thread enters coagulating basin and coagulating bath generation mass exchange, and cellulose is separated out again, now, due to copper ionExist fiber strand silk show light blue, can remove copper ion through pickling, fiber strand silk is bleached, the effect of washing is to removeThe dilute sulfuric acid that previous operation pickling is residual and other chemical substance, if do not remove dilute sulfuric acid, easily damage after being dried and can fallThe intensity of low shaped fibers in hot drafting process, can cause the nascent insect-repellent fiber goods charing of part simultaneously.
Make as-spun fibre obtain better physical and mechanical properties, need to carry out hot drawing-off, make to tanglewrackCellulose macromolecule is under the effect of external tensile force, along the neat arrangement of the axial formation of fiber, the fiber after hot drawing-off, fibreThe large molecule of dimension element forms an organic whole, and the physical and mechanical properties of fiber increases.
The present invention experiment showed, in the time that content of cellulose is 6.5% left and right, and the intensity of nascent insect-repellent fiber is higher, celluloseContent is lower than 6.5% time, and the intensity of as-spun fibre increases along with the increase of content of cellulose, after content of cellulose exceedes 6.5%,The intensity of as-spun fibre diminishes gradually. The concentration of visible spinning solution is larger to the intensity effect of as-spun fibre, tests in spinningIn, content of cellulose is too low, not only has influence on the intensity of as-spun fibre, and causes as-spun fibre a little less than certain position producesRing, the spinning solution that content of cellulose is higher, the fibre structure of preparation is even and closely knit, but content of cellulose is when too high, is spunSilk ribbon comes difficult, and the solubility of cellulose in copper ammon solution is also certain, should adopt as seen the concentration of spinning solutionIt is 6.5% left and right.
Along with the increase of coagulating bath concentration, the brute force of fiber is first to increase, after increasing to a certain degree, reduce gradually,The optium concentration of coagulating bath is near 15%. The concentration of coagulating bath is too low, and the fiber of separating out same amount needs more coagulating bath,Entering in a large number of coagulating bath, makes fiber looser, and fibre strength is lower, in the time that coagulating bath concentration is larger, and coagulating agent and solventExchange too fastly, cause fibre forming too fast, as-spun fibre intensity is declined. The best coagulation bath temperature that the present invention experimental results show thatIt is 35 DEG C.
The test of fiber anthelminthic effect:
Both at home and abroad for anthelminthic effect test also there is no concrete standard, the test of anthelminthic effect be mostly to rise with the Ministry of AgricultureThree standards of grass are as using for reference and reference. These three testing standards are respectively: GB13917.1-1992 " agriculture chemical registration healthWith the assay method of the indoor harmacological effect of pesticide indoor pharmacodynamic test method propellant ", GB/T17322.10-1998 " agricultural chemicalsThe indoor harmacological effect of registration hygienic insecticide is evaluated repellant " and GB13917.3-1992 " agriculture chemical registration hygienic insecticide chamberThe indoor harmacological effect method of testing of the small-sized smoke agent of interior test of pesticide effectiveness method and smog sheet ". The present invention is with reference to these three standards, rightThe actual anthelminthic effect of insect-repellent fiber is tested.
(1) mosquito of collecting is imported to A chamber and the B chamber of mosquito-proof measure of merit case, make the number base of mosquito in two RoomOriginally be consistent; 100% the salt water yield of getting equivalent as bait, is placed in respectively the lower floor of A chamber and B chamber in culture dish;
(2) mosquito is under the attraction of salt, after a while, and when mosquito falls within on the gauze of A chamber and B chamber or arbitrarily dividesBe dispersed in two when indoor, will be put in the upper strata of A chamber drawer without the fiber of mosquito-proof effect, in contrast, mosquito-proof regenerated celulose fibrePut into the upper strata of B chamber drawer; Baffle plate about closing, the active situation of observing mosquito;
(3) after a few minutes, open the baffle plate between two Room, observe mosquito activity direction, treat that the land situation of mosquito is substantially steadyRegularly, the indoor mosquito sum of record two.
Calculate the mosquito repellent rate of the mosquito-proof regenerated celulose fibre of different culicifuge content according to formula (1-1), to this fiberMosquito-proof effect evaluate.
By expelling parasite Chinese medicine additive content be respectively 3.5%, 5.2%, 7%(numbering 1#, 2#, 3#) insect-repellent fiber utilization driveWorm testing arrangement, test anthelminthic effect, test result as shown in Figure 5:
As seen in Figure 5, the anthelminthic effect of insect-repellent fiber element is along with the increase of expelling parasite Chinese medicine additive content, expelling parasiteEffect is become better and better, and is tested from the present invention, and expelling parasite Chinese medicine additive content is too large, gives the system of expelling parasite regenerated celulose fibreFor bringing certain difficulty, in actual production, obtain certain anthelminthic effect, add the content of expelling parasite Chinese medicine additive notBeing less than 5.2% is advisable.
All above-mentioned these intellectual properties of primary enforcement, do not set this new product of the other forms of enforcement of restrictionAnd/or new method. Those skilled in the art will utilize this important information, and foregoing amendment, to realize similar execution feelingsCondition. But all modifications or transformation belong to the right of reservation based on new product of the present invention.
Claims (8)
1. a Chinese medicine expelling parasite additive, is characterized in that, is made up of the bulk drug of following weight portion: 10～20 parts of rhizoma atractylodis are thin10～20 parts of lotuses, 10～20 parts of Radix zanthoxylis, 10～20 parts of kuh-sengs, 10～20 parts of climbing groundsels, 10～20 parts of kaempferia galamgas, calamus 10～20Part, 10～20 parts of tarragons, 10～20 parts of borneols, 10～20 parts of the flower buds of lily magnolia, 10～20 parts of the roots of Chinese wild ginger, 10～20 parts of cloves, windproof 10～20 parts, 10～20 parts of cassia twig, 10～20 parts of Chinese cassia trees, 10～20 parts of rhizoma cyperis, 10～20 parts of the bletilla striatas, 10～20 parts of eupatoriums, fish pelargonium10～20 parts;
The preparation method of described Chinese medicine expelling parasite additive comprises the following steps:
A. get all bulk drugs way of distillation and be vaporized into crystallization, pulverized dusting cover stand-by, as component 1;
B. distillation test residue is extracted 2 times by ethanol heat, merge concentrated extracting solution, as component 2;
E. after component 1 being mixed with component 2, mix well, sterilization tinning is stand-by.
2. Chinese medicine expelling parasite additive according to claim 1, is characterized in that, is made up: grey of the bulk drug of following weight portion10～15 parts of arts, 10～15 parts of peppermints, 10～15 parts of Radix zanthoxylis, 10～15 parts of kuh-sengs, 10～15 parts of climbing groundsels, kaempferia galamga 10～15Part, 10～15 parts of calamus, 10～15 parts of tarragons, 10～15 parts of borneols, 10～20 parts of the flower buds of lily magnolia, 10～20 parts of the roots of Chinese wild ginger, cloves 10～20 parts, windproof 10～20 parts, 10～20 parts of cassia twig, 10～20 parts of Chinese cassia trees, 10～20 parts of rhizoma cyperis, 10～20 parts of the bletilla striatas, eupatorium 10～20 parts, 10～20 parts of fish pelargoniums.
3. Chinese medicine expelling parasite additive according to claim 1, is characterized in that, is made up: grey of the bulk drug of following weight portion10～20 parts of arts, 10～20 parts of peppermints, 10～20 parts of Radix zanthoxylis, 10～20 parts of kuh-sengs, 10～20 parts of climbing groundsels, kaempferia galamga 10～20Part, 10～20 parts of calamus, 10～20 parts of tarragons, 10～20 parts of borneols, 10～15 parts of the flower buds of lily magnolia, 10～15 parts of the roots of Chinese wild ginger, cloves 10～15 parts, windproof 10～15 parts, 10～15 parts of cassia twig, 10～15 parts of Chinese cassia trees, 10～15 parts of rhizoma cyperis, 10～15 parts of the bletilla striatas, eupatorium 10～15 parts, 10～15 parts of fish pelargoniums.
4. a preparation method for Chinese medicine expelling parasite additive as described in any one in claim 1～3, is characterized in that, described inThe preparation method of Chinese medicine expelling parasite additive comprises the following steps:
A. get all bulk drugs way of distillation and be vaporized into crystallization, pulverized dusting cover stand-by, as component 1;
B. distillation test residue is extracted 2 times by ethanol heat, merge concentrated extracting solution, as component 2;
E. after component 1 being mixed with component 2, mix well, sterilization tinning is stand-by.
5. the preparation method of Chinese medicine expelling parasite additive according to claim 4, is characterized in that, in described step a, first by instituteThere is bulk drug steam method to distill, obtain crystal, then pulverize, cross 120-150 mesh sieve, for subsequent use as component 1.
6. the preparation method of Chinese medicine expelling parasite additive according to claim 4, is characterized in that, in described step b, will distillThe residue of the bulk drug that method was extracted, adds and accounts for the alcohol immersion 4-6 hour that its quality 5-10 doubly measures, and heating is extracted 2 times, each1-2 hour, merges extract, after leaving standstill, removes supernatant, and then 100-120 order filters, then is 5000-through the molecular weight that dams10000 ultrafiltration post ultrafiltration, 1.25 filtrate when ultrafiltrate reduced pressure concentration relative density is 80 DEG C, as component 2.
7. the preparation method of Chinese medicine expelling parasite additive according to claim 4, is characterized in that, in described step c, will pulverizePowder crystallization be mixed in the filtrate of component 2, stand-by after ultraviolet radiation for sterilizing and disinfecting.
8. a peppermint underwear fabric, is characterized in that, the raw materials of described underwear fabric comprises: mint fibers and right are wantedAsk the Chinese medicine expelling parasite additive described in any one in 1-3.
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| CN104960480A (en) * | 2015-06-08 | 2015-10-07 | 魏国营 | Inner decorative board assembly with negative-ion partitioned embedded decorative boards, for automobile left rear door |
| CN104924996A (en) * | 2015-06-08 | 2015-09-23 | 魏国营 | Car left front door internal decorative plate with slow-release mosquito expelling function |
| CN105534034A (en) * | 2015-12-15 | 2016-05-04 | 苏州博朗家具有限公司 | Dining table capable of repelling mosquitoes |
| CN110881483A (en) * | 2018-09-05 | 2020-03-17 | 山东海沃嘉美环境工程有限公司 | Plant mosquito-repelling and odor-removing disinfectant for disaster areas |
| CN110882620A (en) * | 2018-09-05 | 2020-03-17 | 山东海沃嘉美环境工程有限公司 | Plant odor-removing antidote for household garbage |
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| CN1156540A (en) * | 1996-09-24 | 1997-08-13 | 南召县供销合作社联合社 | Air pure and fresh disinfectant using folium artemisiae argyi oil as main and preparing process thereof |
| CN1823594A (en) * | 2005-02-25 | 2006-08-30 | 李春年 | Insecticide prepared from pure traditional Chinese medicine |
| CN101049511A (en) * | 2006-04-06 | 2007-10-10 | 张志明 | Air freshness spraying agent |
| CN101181425A (en) * | 2007-11-19 | 2008-05-21 | 王雨良 | Chinese medicine externally used liniment |
| CN103866421A (en) * | 2014-02-25 | 2014-06-18 | 西安工程大学 | Method for preparing anti-mosquito regenerated cellulose fiber |
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| CN1156540A (en) * | 1996-09-24 | 1997-08-13 | 南召县供销合作社联合社 | Air pure and fresh disinfectant using folium artemisiae argyi oil as main and preparing process thereof |
| CN1823594A (en) * | 2005-02-25 | 2006-08-30 | 李春年 | Insecticide prepared from pure traditional Chinese medicine |
| CN101049511A (en) * | 2006-04-06 | 2007-10-10 | 张志明 | Air freshness spraying agent |
| CN101181425A (en) * | 2007-11-19 | 2008-05-21 | 王雨良 | Chinese medicine externally used liniment |
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