CN105251042A - Medical absorbable polyglycolic acid (PGA) operation suture line and preparing method - Google Patents
Medical absorbable polyglycolic acid (PGA) operation suture line and preparing method Download PDFInfo
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Abstract
The invention discloses a medical absorbable polyglycolic acid (PGA) operation suture line. The medical absorbable polyglycolic acid (PGA) operation suture line is mainly prepared from first components including, by mass, 8-12 parts of decumbent bugle herb, 6-10 parts of ovateleaf holly bark, 7-12 parts of cortex phellodendri, 5-9 parts of fructus forsythiae, 8-12 parts of flos magnoliae, 12-16 parts of chrysanthemum, 9-14 parts of cyrtomium fortunei, 7-12 parts of cacumen biotae, 8-15 parts of honeysuckle, 4-7 parts of lalang grass rhizome, 5-8 parts of coptidis rhizome, 7-10 parts of houttuynia cordata and 11-15 parts of clinopodium polycephalum, second components including, by mass, 8-12 parts of polyglycolic acid and 4-6 parts of carboxymethyl chitosan, and third components including, by mass, an appropriate amount of dicumyl peroxide, an appropriate amount of sodium alginate and an appropriate amount of azone. The operation suture line is prepared from carboxymethyl chitosan and polyglycolic acid which are high in biodegradability and some common Chinese herbal medicine, has high biodegradability and a good blood coagulation effect, has the functions of resisting bacteria and eliminating inflammation, and avoids wound infection to a great extent.
Description
Technical field
The present invention relates to field of medical materials, especially relate to a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread and method for making.
Background technology
China Medical Device market is nearly ten years with the annual rate of growth sustainable growth up to 20-27%, far above the 7-10% of international market, but world market share is less than 3% shared by Chinese products, Medical Device Market share is accounted for higher than compared with 40% with the high-tech bio-medical material of international market and goods thereof, Chinese biological medical material industry is very weak, raw material supply manufacturer and production base famine, industrial technology unreasonable structure.Along with development that is biomedical and polymer material science, Degradable Biomedical Materials is just causing people to pay close attention to more and more widely.
Stitching thread is one of the most basic in surgical operation, most important material, is mainly used in variously organizing sewing hemostasis, residual cavity locking and tissue apposition.Be a kind of thread like material sewed up for body operation, from its development history of material development, experienced by silk thread, catgut, chemosynthesis line, pure natural polyglycolic acid stitching thread; Experienced by from absorbability: non-absorbing stitching thread and absorbable suture.Along with the progressively raising of people's living standard and the continuous pursuit to U.S., be more prone to now select assimilation effect better, pulling force is stronger, and combination property is polyglycolic acid stitching thread more preferably.Absorbable suture as: Tendon Suture is also pure natural polyglycolic acid stitching thread, take from special animals tendon tissue, there is many characteristics of polyglycolic acid material, compare with other stitching thread have good absorbing effect, pulling force strong, promote the exclusive functions such as wound healing.
In the sutural method of the existing traditional Chinese medical science, publication number CN104800883A(application number 201510242498.7) patent discloses a kind of absorbable medical suture and preparation method thereof, comprise the component of following weight portion: polyglycolic acid 30-50 part, collagen 16-20 part, chitosan 2.5-3 part, antibacterial 1-2 part, stabilizing agent 1-4 part, Biological cross-linker 2-6 part.Publication number CN104958780A(application number 201510372110.5) patent discloses a kind of medical operation suture thread and preparation method thereof, comprise the following raw material counted by weight: chitosan 1.2-2.8 part, Herba Cymbopogonis Citrari quintessence oil 0.3-1.5 part, glycerol 1.2-1.8 part, hyaluronic acid 0.05-0.08 part, vitamin E 0.1-0.8 part, Cuttlefish soup 0.1-0.8 part.Publication number CN104841007A(application number 201510315358.8) patent discloses a kind of suture and preparation method thereof, comprise the following steps: step one: at 30-40 DEG C, freshly extd animal tendon is contacted 1-2h with treatment fluid 1 and obtain tendon raw material 1; Step 2: at 30-40 DEG C, described tendon raw material 1 is contacted 1-2h with treatment fluid 2 and obtain tendon raw material 2; Step 3: at 15-30 DEG C, described tendon raw material 2 is contacted 0.5-1h with treatment fluid 3 and obtain tendon raw material 3; Step 4: by described tendon raw material 3 and O at 15-30 DEG C
3contact 0.5-1h obtains tendon raw material 4; Step 5: described tendon raw material 4 is contacted 20-30h at 15-30 DEG C with medical alcohol and be cured and obtain tendon raw material 5; Wherein, the constituent of described treatment fluid 1 is pepsin and/or acetic acid; The constituent of described treatment fluid 2 is trypsin and/or NaCO
3; The constituent of described treatment fluid 3 is NaClO and/or NaOH.
Existing stitching thread majority is all the suture of nonabsorable, and postoperative again taking out stitches brings larger misery to patient, and most consumer is difficult to accept.But at present absorbable suture not only costly, and just simple stitching thread effect, the effects such as not certain bactericidal antiphlogistic, use and easily cause wound infection afterwards.
Summary of the invention
For the deficiencies in the prior art, an object of the present invention is to provide a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, the good carboxymethyl chitosan of biodegradability and polyglycolic acid and some Common Chinese Herbs is adopted to make, there is good biocompatibility and biodegradability, there is good coagulating effectiveness, there is effect of inhibiting bacteria and diminishing inflammation, avoid the infection of wound to a great extent.Another object is just to provide the preparation method of above-mentioned a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, takes off the primary raw material stating quality proportioning and is prepared from: the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-12 part, Cortex Ilicis Rotundae 6-10 part, Cortex Phellodendri 7-12 part, Fructus Forsythiae 5-9 part, Flos Magnoliae 8-12 part, Flos Chrysanthemi 12-16 part, Rhizoma Osmundae 9-14 part, Cacumen Platycladi 7-12 part, Flos Lonicerae 8-15 part, Rhizoma Imperatae 4-7 part, Rhizoma Coptidis 5-8 part, Herba Houttuyniae 7-10 part, Herba Clinopodii 11-15 part.Second component: polyglycolic acid 8-12 part, carboxymethyl chitosan 4-6 part.Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
A kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, preferred scheme is, takes off the primary raw material stating quality proportioning and is prepared from: the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 9-11 part, Cortex Ilicis Rotundae 7-9 part, Cortex Phellodendri 9-11 part, Fructus Forsythiae 6-8 part, Flos Magnoliae 9-11 part, Flos Chrysanthemi 13-15 part, Rhizoma Osmundae 11-13 part, Cacumen Platycladi 9-11 part, Flos Lonicerae 11-13 part, Rhizoma Imperatae 5-6 part, Rhizoma Coptidis 6-7 part, Herba Houttuyniae 8-9 part, Herba Clinopodii 12-14 part.Second component: polyglycolic acid 9-11 part, carboxymethyl chitosan 4.5-5.5 part.Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
A kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, the scheme be more preferably is, takes off the primary raw material stating quality proportioning and is prepared from: the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10 parts, Cortex Ilicis Rotundae 8 parts, Cortex Phellodendri 10 parts, Fructus Forsythiae 7 parts, Flos Magnoliae 10 parts, Flos Chrysanthemi 14 parts, Rhizoma Osmundae 12 parts, Cacumen Platycladi 10 parts, Flos Lonicerae 12 parts, Rhizoma Imperatae 5.5 parts, Rhizoma Coptidis 6.5 parts, Herba Houttuyniae 8.5 parts, Herba Clinopodii 13 parts.Second component: polyglycolic acid 10 parts, carboxymethyl chitosan 5 parts.Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
The preparation method of above-mentioned a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, step is as follows:
1. by Cortex Ilicis Rotundae and Rhizoma Osmundae fried dry, smash to pieces, the blank sheet of paper of wide 150-200mm is placed on the bottom of pot, the Cortex Ilicis Rotundae smashed to pieces and Rhizoma Osmundae are poured in the middle of blank sheet of paper, slow fire heats, smog of emerging, and stops heating when smog is gradually reduced to disappearance, removing paper scrap, by medicine porphyrize, crosses 160-200 mesh sieve;
2. by Cortex Phellodendri, Cacumen Platycladi, Rhizoma Imperatae and Rhizoma Coptidis section, be placed in container, add rice wine, moistening 4-6 hour;
3. Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Fructus Forsythiae, Flos Magnoliae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae and Herba Clinopodii are broken into coarse powder, add dissolved in purified water 20-30 minute, add step 2. gains, water extraction twice, each extraction 40-60 minute, merge extractive liquid;
4. by step 1. gained medicated powder join step 3. in gained extracting solution, stir 3-5 minute, adding second acid for adjusting pH is 3-4, and leave standstill 2-4 hour, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
5. polyglycolic acid is placed in container, add medicinal liquid 1 and dissolve 5-10 minute, be placed in homogenizer, add carboxymethyl chitosan, cumyl peroxide and sodium alginate, high-speed stirred 15-20 minute, add laurocapram, continue to stir 4-6 minute, froth breaking, makes spinning solution, leaves standstill 10-15 hour;
6. by spinning solution through 4-12mm SPINNERETS FOR MELT SPINNING spray webbing, the monofilament lines of the obtained different size that the water-bath of gained spray webbing fiber stretched, is washed to neutrality, carries out showering coloring agent, cold drying;
7. by 30-50 minute in step 6. gains immersion medical alcohol, carry out sterilizing, vacuum drying is packed, and obtains operation suture thread.
The preparation method of above-mentioned a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, preferred scheme is: step is 1. preferred crosses 170-190 mesh sieve, is more preferably 180 mesh sieves.
The preparation method of above-mentioned a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, preferred scheme is: step 2. preferably the consumption of rice wine be the 20%-30% of quality of medicinal material, the consumption being more preferably rice wine is 25% of quality of medicinal material.
The preparation method of above-mentioned a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, preferred scheme is: step is 3. preferably each extracts 45-55 minute, is more preferably each extraction 50 minutes.
The preparation method of above-mentioned a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, preferred scheme is: 4. step preferably adds second acid for adjusting pH is 3.3-3.7, is more preferably that to add second acid for adjusting pH be 3.5.
The preparation method of above-mentioned a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, preferred scheme is: step 5. preferred rotating speed is 200 revs/min-300 revs/min, and being more preferably rotating speed is 250 revs/min.
The preparation method of above-mentioned a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, preferred scheme is: 7. step preferably immerses 35-45 minute in medical alcohol, is more preferably and immerses in medical alcohol 40 minutes.
Using method: after common wound sterilization, is used for postoperative wound by suture of the present invention or wound needs suture needle place.
Beneficial effect of the present invention is mainly reflected in:
1, a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread of the present invention adopts the good carboxymethyl chitosan of biodegradability and polyglycolic acid and some Common Chinese Herbs to make, there is good biocompatibility and biodegradability, there is good coagulating effectiveness, there is effect of inhibiting bacteria and diminishing inflammation, avoid the infection of wound to a great extent.
2, operation suture thread of the present invention has good biocompatibility and biodegradability, non-stimulated to organizing, and has no side effect, and NIP reacts, and accelerates the healing of wound, and Human Tolerance is good, avoids the misery of taking out stitches and bringing to patient.
3, the easy soft easy knotting of stitching thread of the present invention, intensity and pliability moderate, skin-friction coefficient is little, be easy to sew up and knotting.
4, the body absorption phase of operation suture thread of the present invention is 15-22 days, can meet clinical needs completely.And the degradation rate deposited under felicity condition is in vitro minimum.
5, operation suture thread of the present invention has good biodegradability, uniform absorption after implanting, can biodegradation in body, can absorb completely, and without obvious stitch vestige after wound healing.
6, the raw material sources of operation suture thread of the present invention are extensive, and cost is low.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, takes off and states primary raw material and be prepared from (getting 80g for every part): the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8 parts, Cortex Ilicis Rotundae 6 parts, Cortex Phellodendri 7 parts, Fructus Forsythiae 5 parts, Flos Magnoliae 8 parts, Flos Chrysanthemi 12 parts, Rhizoma Osmundae 9 parts, Cacumen Platycladi 7 parts, Flos Lonicerae 8 parts, Rhizoma Imperatae 4 parts, Rhizoma Coptidis 5 parts, Herba Houttuyniae 7 parts, Herba Clinopodii 11 parts.Second component: polyglycolic acid 8 parts, carboxymethyl chitosan 4 parts.Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
A kind of Medical absorbable polyglycolic acid (PGA) operation suture thread preparation process is as follows:
1. by Cortex Ilicis Rotundae and Rhizoma Osmundae fried dry, smash to pieces, the blank sheet of paper of wide 150mm is placed on the bottom of pot, the Cortex Ilicis Rotundae smashed to pieces and Rhizoma Osmundae are poured in the middle of blank sheet of paper, slow fire heats, smog of emerging, and stops heating when smog is gradually reduced to disappearance, removing paper scrap, by medicine porphyrize, crosses 160 mesh sieves;
2. by Cortex Phellodendri, Cacumen Platycladi, Rhizoma Imperatae and Rhizoma Coptidis section, be placed in container, add rice wine, moistening 4 hours;
3. Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Fructus Forsythiae, Flos Magnoliae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae and Herba Clinopodii are broken into coarse powder, add dissolved in purified water 20 minutes, add step 2. gains, water extraction twice, each extraction 40 minutes, merge extractive liquid;
4. by step 1. gained medicated powder join step 3. in gained extracting solution, stir 3 minutes, adding second acid for adjusting pH is 3, and leave standstill 2 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
5. polyglycolic acid is placed in container, adds medicinal liquid 1 and dissolve 5 minutes, be placed in homogenizer, add carboxymethyl chitosan, cumyl peroxide and sodium alginate, high-speed stirred 15 minutes, adds laurocapram, continues stirring 4 minutes, froth breaking, makes spinning solution, leaves standstill 10 hours;
6. by spinning solution through 4mm SPINNERETS FOR MELT SPINNING spray webbing, the monofilament lines of the obtained different size that the water-bath of gained spray webbing fiber stretched, is washed to neutrality, carries out showering coloring agent, cold drying;
7. by step 6. gains to immerse in medical alcohol 30 minutes, carry out sterilizing, vacuum drying is packed, and obtains operation suture thread.
Using method: after common wound sterilization, is used for postoperative wound by suture of the present invention or wound needs suture needle place.
embodiment 2a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, takes off and states primary raw material and be prepared from (getting 20g for every part): the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 12 parts, Cortex Ilicis Rotundae 10 parts, Cortex Phellodendri 12 parts, Fructus Forsythiae 9 parts, Flos Magnoliae 12 parts, Flos Chrysanthemi 16 parts, Rhizoma Osmundae 14 parts, Cacumen Platycladi 12 parts, Flos Lonicerae 15 parts, Rhizoma Imperatae 7 parts, Rhizoma Coptidis 8 parts, Herba Houttuyniae 10 parts, Herba Clinopodii 15 parts.Second component: polyglycolic acid 12 parts, carboxymethyl chitosan 6 parts.Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
A kind of preparation process of Medical absorbable polyglycolic acid (PGA) operation suture thread is as follows:
1. by Cortex Ilicis Rotundae and Rhizoma Osmundae fried dry, smash to pieces, the blank sheet of paper of wide 200mm is placed on the bottom of pot, the Cortex Ilicis Rotundae smashed to pieces and Rhizoma Osmundae are poured in the middle of blank sheet of paper, slow fire heats, smog of emerging, and stops heating when smog is gradually reduced to disappearance, removing paper scrap, by medicine porphyrize, crosses 200 mesh sieves;
2. by Cortex Phellodendri, Cacumen Platycladi, Rhizoma Imperatae and Rhizoma Coptidis section, be placed in container, add rice wine, moistening 6 hours;
3. Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Fructus Forsythiae, Flos Magnoliae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae and Herba Clinopodii are broken into coarse powder, add dissolved in purified water 30 minutes, add step 2. gains, water extraction twice, each extraction 60 minutes, merge extractive liquid;
4. by step 1. gained medicated powder join step 3. in gained extracting solution, stir 5 minutes, adding second acid for adjusting pH is 4, and leave standstill 4 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
5. polyglycolic acid is placed in container, adds medicinal liquid 1 and dissolve 10 minutes, be placed in homogenizer, add carboxymethyl chitosan, cumyl peroxide and sodium alginate, high-speed stirred 20 minutes, adds laurocapram, continues stirring 6 minutes, froth breaking, makes spinning solution, leaves standstill 15 hours;
6. by spinning solution through 12mm SPINNERETS FOR MELT SPINNING spray webbing, the monofilament lines of the obtained different size that the water-bath of gained spray webbing fiber stretched, is washed to neutrality, carries out showering coloring agent, cold drying;
7. by step 6. gains to immerse in medical alcohol 50 minutes, carry out sterilizing, vacuum drying is packed, and obtains operation suture thread.
Using method: after common wound sterilization, is used for postoperative wound by suture of the present invention or wound needs suture needle place.
model case onekorea Spro XX, female, 46 years old, Shandong Province Laiwu City people.Approximately the year before, Mrs Han finds that unintentionally abdominal part has the lump of a Semen arachidis hypogaeae size, removable, and pressing is without pain.It is tumor that Mrs Han worries, so remove examination in hospital, is diagnosed as lipoma after inspection, has not big harm, so do not implement treatment.Half a year how after, Mrs Han realizes that the lipoma of abdominal part is increasing, so decision excision, perform the operation very well, a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread of postoperative use the present invention carries out interior stitching, within 5 days, afterwards substantially without pain, wound healing is better, and also drier around the edge of a knife.After 1 month, stitching thread is absorbed completely, and the later stage visits and learns that wound heals completely, and does not have scar.
embodiment 3a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, takes off and states primary raw material and be prepared from (getting 50g for every part): the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 9 parts, Cortex Ilicis Rotundae 7 parts, Cortex Phellodendri 9 parts, Fructus Forsythiae 6 parts, Flos Magnoliae 9 parts, Flos Chrysanthemi 13 parts, Rhizoma Osmundae 11 parts, Cacumen Platycladi 9 parts, Flos Lonicerae 11 parts, Rhizoma Imperatae 5 parts, Rhizoma Coptidis 6 parts, Herba Houttuyniae 8 parts, Herba Clinopodii 12 parts.Second component: polyglycolic acid 9 parts, carboxymethyl chitosan 4.5 parts.Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
A kind of Medical absorbable polyglycolic acid (PGA) operation suture thread preparation process is as follows:
1. by Cortex Ilicis Rotundae and Rhizoma Osmundae fried dry, smash to pieces, the blank sheet of paper of wide 170mm is placed on the bottom of pot, the Cortex Ilicis Rotundae smashed to pieces and Rhizoma Osmundae are poured in the middle of blank sheet of paper, slow fire heats, smog of emerging, and stops heating when smog is gradually reduced to disappearance, removing paper scrap, by medicine porphyrize, crosses 170 mesh sieves;
2. by Cortex Phellodendri, Cacumen Platycladi, Rhizoma Imperatae and Rhizoma Coptidis section, be placed in container, add rice wine, moistening 4.5 hours;
3. Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Fructus Forsythiae, Flos Magnoliae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae and Herba Clinopodii are broken into coarse powder, add dissolved in purified water 23 minutes, add step 2. gains, water extraction twice, each extraction 45 minutes, merge extractive liquid;
4. by step 1. gained medicated powder join step 3. in gained extracting solution, stir 3.5 minutes, adding second acid for adjusting pH is 3.3, and leave standstill 2.5 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
5. polyglycolic acid is placed in container, adds medicinal liquid 1 and dissolve 7 minutes, be placed in homogenizer, add carboxymethyl chitosan, cumyl peroxide and sodium alginate, high-speed stirred 17 minutes, adds laurocapram, continues stirring 4.5 minutes, froth breaking, makes spinning solution, leaves standstill 12 hours;
6. by spinning solution through 7mm SPINNERETS FOR MELT SPINNING spray webbing, the monofilament lines of the obtained different size that the water-bath of gained spray webbing fiber stretched, is washed to neutrality, carries out showering coloring agent, cold drying;
7. by step 6. gains to immerse in medical alcohol 35 minutes, carry out sterilizing, vacuum drying is packed, and obtains operation suture thread.
Using method: after common wound sterilization, is used for postoperative wound by suture of the present invention or wound needs suture needle place.
embodiment 4a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, takes off and states primary raw material and be prepared from (getting 30g for every part): the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 11 parts, Cortex Ilicis Rotundae 9 parts, Cortex Phellodendri 11 parts, Fructus Forsythiae 8 parts, Flos Magnoliae 11 parts, Flos Chrysanthemi 15 parts, Rhizoma Osmundae 13 parts, Cacumen Platycladi 11 parts, Flos Lonicerae 13 parts, Rhizoma Imperatae 6 parts, Rhizoma Coptidis 7 parts, Herba Houttuyniae 9 parts, Herba Clinopodii 14 parts.Second component: polyglycolic acid 11 parts, carboxymethyl chitosan 5.5 parts.Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
A kind of Medical absorbable polyglycolic acid (PGA) operation suture thread preparation process is as follows:
1. by Cortex Ilicis Rotundae and Rhizoma Osmundae fried dry, smash to pieces, the blank sheet of paper of wide 190mm is placed on the bottom of pot, the Cortex Ilicis Rotundae smashed to pieces and Rhizoma Osmundae are poured in the middle of blank sheet of paper, slow fire heats, smog of emerging, and stops heating when smog is gradually reduced to disappearance, removing paper scrap, by medicine porphyrize, crosses 190 mesh sieves;
2. by Cortex Phellodendri, Cacumen Platycladi, Rhizoma Imperatae and Rhizoma Coptidis section, be placed in container, add rice wine, moistening 5.5 hours;
3. Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Fructus Forsythiae, Flos Magnoliae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae and Herba Clinopodii are broken into coarse powder, add dissolved in purified water 27 minutes, add step 2. gains, water extraction twice, each extraction 55 minutes, merge extractive liquid;
4. by step 1. gained medicated powder join step 3. in gained extracting solution, stir 4.5 minutes, adding second acid for adjusting pH is 3.7, and leave standstill 3.5 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
5. polyglycolic acid is placed in container, adds medicinal liquid 1 and dissolve 9 minutes, be placed in homogenizer, add carboxymethyl chitosan, cumyl peroxide and sodium alginate, high-speed stirred 19 minutes, adds laurocapram, continues stirring 5.5 minutes, froth breaking, makes spinning solution, leaves standstill 14 hours;
6. by spinning solution through 9mm SPINNERETS FOR MELT SPINNING spray webbing, the monofilament lines of the obtained different size that the water-bath of gained spray webbing fiber stretched, is washed to neutrality, carries out showering coloring agent, cold drying;
7. by step 6. gains to immerse in medical alcohol 45 minutes, carry out sterilizing, vacuum drying is packed, and obtains operation suture thread.
Using method: after common wound sterilization, is used for postoperative wound by suture of the present invention or wound needs suture needle place.
model case twoyellow XX, man, 36 years old, people from Dezhou City Shandong Province.Mr. Huang is a builder, accidentally throws from eminence more than a year in a construction working, causes right lower limb leg femur comminuted fracture and right arm fracture, needs surgical menopause.Operation process is very well, and a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread of postoperative use the present invention carries out wound suture, and 5 days after operation is without pain, and postoperative incision recovers good, occurs without malaise symptoms such as infection.After 1 month, stitching thread is completely absorbed, and wound is without obvious cicatrix.Later stage visits and learns that wound recovers positive normal skin tone completely, does not leave obvious cicatrix.
embodiment 5a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread, takes off and states primary raw material and be prepared from (getting 50g for every part): the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10 parts, Cortex Ilicis Rotundae 8 parts, Cortex Phellodendri 10 parts, Fructus Forsythiae 7 parts, Flos Magnoliae 10 parts, Flos Chrysanthemi 14 parts, Rhizoma Osmundae 12 parts, Cacumen Platycladi 10 parts, Flos Lonicerae 12 parts, Rhizoma Imperatae 5.5 parts, Rhizoma Coptidis 6.5 parts, Herba Houttuyniae 8.5 parts, Herba Clinopodii 13 parts.Second component: polyglycolic acid 10 parts, carboxymethyl chitosan 5 parts.Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
A kind of Medical absorbable polyglycolic acid (PGA) operation suture thread preparation process is as follows:
1. by Cortex Ilicis Rotundae and Rhizoma Osmundae fried dry, smash to pieces, the blank sheet of paper of wide 180mm is placed on the bottom of pot, the Cortex Ilicis Rotundae smashed to pieces and Rhizoma Osmundae are poured in the middle of blank sheet of paper, slow fire heats, smog of emerging, and stops heating when smog is gradually reduced to disappearance, removing paper scrap, by medicine porphyrize, crosses 180 mesh sieves;
2. by Cortex Phellodendri, Cacumen Platycladi, Rhizoma Imperatae and Rhizoma Coptidis section, be placed in container, add rice wine, moistening 5 hours;
3. Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Fructus Forsythiae, Flos Magnoliae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae and Herba Clinopodii are broken into coarse powder, add dissolved in purified water 25 minutes, add step 2. gains, water extraction twice, each extraction 50 minutes, merge extractive liquid;
4. by step 1. gained medicated powder join step 3. in gained extracting solution, stir 4 minutes, adding second acid for adjusting pH is 3.5, and leave standstill 3 hours, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
5. polyglycolic acid is placed in container, adds medicinal liquid 1 and dissolve 8 minutes, be placed in homogenizer, add carboxymethyl chitosan, cumyl peroxide and sodium alginate, high-speed stirred 18 minutes, adds laurocapram, continues stirring 5 minutes, froth breaking, makes spinning solution, leaves standstill 18 hours;
6. by spinning solution through 8mm SPINNERETS FOR MELT SPINNING spray webbing, the monofilament lines of the obtained different size that the water-bath of gained spray webbing fiber stretched, is washed to neutrality, carries out showering coloring agent, cold drying;
7. by step 6. gains to immerse in medical alcohol 40 minutes, carry out sterilizing, vacuum drying is packed, and obtains operation suture thread.
Using method: after common wound sterilization, is used for postoperative wound by suture of the present invention or wound needs suture needle place.
The pharmacological effect of each crude drug is respectively:
Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.): bitter in the mouth, cold in nature.For the herb of Labiatae bugle Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.).There is heat-clearing and toxic substances removing, effect of removing heat from blood suppressing the hyperactive liver.For upper respiratory tract infection, tonsillitis, pharyngitis, bronchitis, pneumonia, lung abscess, gastroenteritis, hepatitis, appendicitis, mastitis, acute conjunctivitis, hypertension; Traumatic injury is controlled in external, traumatic hemorrhage, carbuncle furuncle infections, burn and scald, venom.
Cortex Ilicis Rotundae: bitter in the mouth, cool in nature.Return lung, liver, large intestine channel.Another name: silver bark, Semen Sterculiae Nobilis, white orchid are fragrant, Fel Ursi is wooden.For bark or the root bark of holly plant Ilex rotunda Thunb..Containing flavonoid glycoside, phenols, tannin, Triterpene Glycosides, and isolate β-Amyrin, cupreol and stearic acid.Leaf contains flavonoid glycoside, phenols, aminoacid, saccharide, triterpene.Seed is containing oleanolic acid, rotundic acid.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.For flu, tonsillitis, laryngopharynx swelling and pain, acute gastroenteritis, rheumatic ostalgia; Traumatic injury is controlled in external, carbuncle furuncle infections, traumatic hemorrhage, burn and scald.
Cortex Phellodendri: bitter in the mouth, cold in nature.Return kidney, urinary bladder channel.For the dry bark of rutaceae wampee.Have heat clearing and damp drying, pathogenic fire purging removes steams, effect of detoxification sore treatment.For inflammation damp-heat dysenteries such as acute bacillary dysentery, acute enteritis, acute icterohepatitis, urinary system infections, jaundice, pyretic stranguria, beriberi ， flaccidity of feet with lamenness, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.
Fructus Forsythiae: bitter in the mouth, cold in nature.Return lung, the heart, small intestine meridian.For the dry fruit of Oleaceae plants Fructus Forsythiae.There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, antibacterial, heart tonifying, diuresis, effect that town is told.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Flos Magnoliae: acrid in the mouth, warm in nature.Attach to the lung and stomach meridians.For the dry flower of Magnoliacea plant Flos Magnoliae, Magnolia denudata or Flos Magnoliae.There is dispersing wind and cold, effect of clearing the nasal passage.For headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge.
Flos Chrysanthemi: sweet in the mouth, hardship, cold nature.Return lung, Liver Channel.For the dry capitulum of feverfew chrysanthemum.There is loose wind heat clearing away, effect of suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.
Rhizoma Osmundae: bitter in the mouth, puckery, cold nature.Return liver, stomach warp.For rhizome and the petiole residual base of Dryopteridaceae plant dryopteris crassirhizoma.There is parasite killing, heat clearing away, removing toxic substances, effect of cooling blood for hemostasis.For anemopyretic cold, warm skin eruption, spit blood, hemoptysis, epistaxis, has blood in stool, metrorrhagia, dysentery, the intestinal parasitic diseases such as leukorrhagia and hook, ascarid, cestode.
Cacumen Platycladi: bitter in the mouth, puckery, cold in nature.Return lung, liver, spleen channel.For the dry branch tip and leaf of Cupressaceae plant Cacumen Platycladi.There is cooling blood for hemostasis, effect of growing and blacking hair.For hematemesis and epistaxis, spitting of blood, has blood in stool, metrostaxis, heat in blood alopecia, early whitening of beard and hair.
Flos Lonicerae: sweet in the mouth, cold in nature.Return lung, the heart, stomach warp.For the flower that dry flower or the band of caprifoliaceae plant Radix Ophiopogonis are just opened.There is heat-clearing and toxic substances removing, effect of wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat, various febrile disease (as fever of the body, dermexanthesis, sending out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain).
Rhizoma Imperatae: sweet in the mouth, cold in nature.Return lung, stomach, urinary bladder channel.For the dry rhizome of grass Herba Imperatae, Arundoin, Coixol, fernenol, simiarenol, Isoarborinol, Anemonin, also containing sterols: stigmasterol, cupreol, campesterol, saccharide, volume sucrose, glucose and a small amount of fructose, xylose, simple acids: citric acid, oxalic acid and malic acid.There is cooling blood for hemostasis, effect of heat-clearing and toxic substances removing.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria, acute nephritis edema, dysuria, gastric heat is vomitted the sound of vomiting, coughs.
Rhizoma Coptidis: bitter in the mouth, cold in nature.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.For the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.There is heat clearing and damp drying, effect of eliminating fire and detoxication.Tie mutually for cold and heat, damp and hot middle resistance, feeling of fullness is vomitted.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.For incoordination between the liver and stomach, vomiting acid regurgitation.
Herba Houttuyniae: acrid in the mouth, cold nature.Return lung meridian.For fresh herb or the dry aerial parts of saururaceae plant houttuynia cordata.There is heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, effect of inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.
Herba Clinopodii: mildly bitter flavor, puckery, cool in nature.Return Liver Channel.For the dry aerial parts of the labiate Clinopodium Polycephalum Herba Clinopodii (Herba Clinopodii Polycephali) or Herba Clinopodii Polycephali.There is effect of hemostasis.For metrorrhagia, hematuria, epistaxis, gingival hemorrhage, wound hemorrhage, hysteromyoma hemorrhage.
Polyglycolic acid: be a kind of synthesized polymer material with good biodegradability properties and biocompatibility, different from the macromolecular material of traditional stable performance, polyglycolic acid is degraded after using certain hour gradually as material, and finally becomes the harmless water of human body, animals and plants and natural environment and carbon dioxide.The application of polyglycolic acid is mainly manifested in biomedical and ecological two aspects, and biomedical applications is mainly manifested in suture, medicine controlled release carrier, fracture fixation material, tissue engineering bracket, stitch reinforce material.
Carboxymethyl chitosan: be a kind of water-solubility chitosan derivative, is a kind of chemical industry synthetic occurred in recent years, in medicine, chemical industry, environmental protection, health product, has important meaning.It makes chitosan by carboxymethyl chitosan de-acetyl under acid or alkali condition, then (under being generally alkali condition) and chloroacetate reaction are produced and formed under proper condition by chitosan.With carboxymethyl chitosan, chitosan comparatively speaking, its advantage with can dissolve in neutral, alkalescence and subacidity water, and character is more stable.And its stable character and antibacterial anti-infection, blood fat reducing and prevent and treat the pharmacological actions such as arteriosclerosis and be doomed that it will play a greater role in the daily life of human future is a kind of polyampholyte etc.Cosmetics, fresh-keeping, medical etc. in have multiple application, be also that Recent study obtains one of more chitosan derivatives.
Cumyl peroxide: the initiator that can be used as monomer polymerization, the vulcanizing agent, cross-linking agent firming agent, flame-retardant additive etc. of macromolecular material.And be the most frequently used cross-linking agent, be also use as cross-linking agent in the present invention.Room-temperature stable, is shown in that light becomes micro-yellow gradually.Cumyl peroxide can make eva foam material form fine and even foam, improves thermostability simultaneously; Also the initiator of high polymer is used as; As the cross-linking agent of acrylonitrile-butadiene rubber, neoprene, polystyrene etc.; During as free radical suspensioning polymerization initiator, redox initiator can be formed with reducing agent ferrous salt; Also can be used as the cross-linking agent of the firming agent of unsaturated polyester (UP), phenolic aldehyde butyronitrile adhesive, improve thermostability and resistance to ag(e)ing.
Sodium alginate: a kind of natural polysaccharide, has the stability needed for pharmaceutical preparation adjuvant, dissolubility, viscosity and safety.Most common use: the sizing agent and the printing paste that are 1. used as textile, be widely used in food industry as thickening agent, stabilizing agent, emulsifying agent simultaneously.2. make emulsion stabilizer and thickening agent, China's regulation can be used for varieties of food items, uses in right amount by need of production.3. stabilizing agent, thickening agent, emulsifying agent, dispersant, gellant, fruit glaze agent, suspending agent.4. for increasing blood volume with maintain blood pressure, get rid of the whole body such as the histamine toxoid that produces and wound is lost blood, the stablizing of perioperatively blood circulation, bleeding profusely property shock, burn shock, hyperpyrexia and acute dysentery of burning and dewater, therapeutic effect is good.Mainly on medicament be used as suspending agent, emulsifying agent, sticky dose, the capsule material etc. of microcapsule.As long as play the effect of stabilizing agent in stitching thread of the present invention.
Laurocapram: pharmaceutic adjuvant, for colourless to the oily liquids of yellowish clarification.As penetrating agent, for cream frost all kinds of in cosmetics and hair care product; The penetrating agent of smear as external used medicine, massaging; For pesticide, as the penetrating agent of the short vapor of plant growth regulator and sterilization, insecticide; For the painted promoter in the field such as leather and printing and dyeing.Skin chromaticness layer lipid and protein structure can be changed, promote that drug percutaneous skin absorbs, its transdermal effect can be strengthened to hydrophilic and hydrophobic compound, generally can work at low concentration (0.5-2%).To skin, mucosa nonirritant, in ointment, cream, liniment, add this product all can play Transdermal absorption effect.Can be used as the adjuvant of the medicine for external use such as ointment, cream, liniment.Antibacterial is mainly used in suture of the present invention.
test example: in order to verify the curative effect of a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread (embodiment 5) of the present invention: in February ,-2011 in April, 2010 has done series of contrast.
Test 1: tensile strength is tested
Screen the patient that 150 examples need to finish operation, be divided into experimental group and matched group two groups at random, wherein experimental group has 100 people, and matched group has 50 people.Experimental group uses a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread of the present invention, after common wound sterilization, suture of the present invention is used for postoperative wound or wound needs suture needle place.Matched group uses other stitching thread, as nylon suture.Other sutural tensile strength that the stitching thread of the present invention adopting stitching thread tension tester test experience group to use and matched group use, test intensity results is as follows: can be obtained by tensile strength experiment in body, in the 10 day time after using stitching thread, nylon suture is hydrolyzed gradually, its tensile strength weakens gradually, and a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread of the present invention is without significant change, tensile strength is better.
Test 2: absorbing state (biodegradability) is tested
Screening 150 body weight is the white mice of 20-25g, be divided into experimental group and contrast immediately, wherein experimental group 100, matched group 50, abdominal part aseptic incision 2cm is carried out to every white mice, experimental group uses a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread of the present invention to sew up wound, matched group adopts stitching thread (the PGA suture of chemosynthesis, purchased from Nantong Hua Likang Medical Devices Co., Ltd.) wound is sewed up, then stitching thread in animal body the 5th is got, 12, otch sample when 20 days does HE stained, and examine under a microscope sutural absorbing state, as can be seen from assimilation effect, stitching thread of the present invention the 5th day time substantially without absorption, ensure that sutural basic stitching effect, be completely absorbed the 20th day time, and matched group absorbing state is undesirable, still do not occur when the 20th day absorbing, need postoperative taking out stitches.
Test 3: the situation of wound healing and desalination cicatrix
Screen the patient that 200 examples need to finish operation, be divided into experimental group and matched group two groups at random, wherein experimental group has 150 people, and matched group has 50 people.Experimental group uses a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread of the present invention, after common wound sterilization, suture of the present invention is used for postoperative wound or wound needs suture needle place.Matched group uses other stitching thread, as nylon suture.It is as follows that the healing time of observation experiment group and matched group and cicatrix desalinate situation, and the average healing of experimental group is 12.7 days, and the average healing of matched group is 17.9 days; And during after sew up wound 45 days, the patient more than 93% of experimental group, without cicatrix sign, only have the patient less than 7% to have lighter cicatrix, and matched group has the patient more than 94% to have obvious cicatrix, only has the patient less than 6% to have slight cicatrix.
To sum up test 1-3 and can find out operation suture thread anti-inflammation better effects if of the present invention, effectively promote wound healing, there is effect of desalination cicatrix, accelerating wound better, shorten healing time, and biological degradability of the present invention is good, avoids the misery of again taking out stitches and bringing to patient.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. Medical absorbable polyglycolic acid (PGA) operation suture thread, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from (being weight portion): the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 8-12 part, Cortex Ilicis Rotundae 6-10 part, Cortex Phellodendri 7-12 part, Fructus Forsythiae 5-9 part, Flos Magnoliae 8-12 part, Flos Chrysanthemi 12-16 part, Rhizoma Osmundae 9-14 part, Cacumen Platycladi 7-12 part, Flos Lonicerae 8-15 part, Rhizoma Imperatae 4-7 part, Rhizoma Coptidis 5-8 part, Herba Houttuyniae 7-10 part, Herba Clinopodii 11-15 part; Second component: polyglycolic acid 8-12 part, carboxymethyl chitosan 4-6 part; Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
2. a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread according to claim 1, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from (being weight portion): the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 9-11 part, Cortex Ilicis Rotundae 7-9 part, Cortex Phellodendri 9-11 part, Fructus Forsythiae 6-8 part, Flos Magnoliae 9-11 part, Flos Chrysanthemi 13-15 part, Rhizoma Osmundae 11-13 part, Cacumen Platycladi 9-11 part, Flos Lonicerae 11-13 part, Rhizoma Imperatae 5-6 part, Rhizoma Coptidis 6-7 part, Herba Houttuyniae 8-9 part, Herba Clinopodii 12-14 part; Second component: polyglycolic acid 9-11 part, carboxymethyl chitosan 4.5-5.5 part; Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
3. a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread according to claim 1, it is characterized in that, take off the primary raw material stating quality proportioning and be prepared from (being weight portion): the first component: Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.) 10 parts, Cortex Ilicis Rotundae 8 parts, Cortex Phellodendri 10 parts, Fructus Forsythiae 7 parts, Flos Magnoliae 10 parts, Flos Chrysanthemi 14 parts, Rhizoma Osmundae 12 parts, Cacumen Platycladi 10 parts, Flos Lonicerae 12 parts, Rhizoma Imperatae 5.5 parts, Rhizoma Coptidis 6.5 parts, Herba Houttuyniae 8.5 parts, Herba Clinopodii 13 parts; Second component: polyglycolic acid 10 parts, carboxymethyl chitosan 5 parts; Three components: cumyl peroxide is appropriate, sodium alginate is appropriate, laurocapram is appropriate.
4., according to the preparation method of arbitrary described a kind of Medical absorbable polyglycolic acid (PGA) operation suture thread of claim 1-3, it is characterized in that, step is as follows:
1. by Cortex Ilicis Rotundae and Rhizoma Osmundae fried dry, smash to pieces, the blank sheet of paper of wide 150-200mm is placed on the bottom of pot, the Cortex Ilicis Rotundae smashed to pieces and Rhizoma Osmundae are poured in the middle of blank sheet of paper, slow fire heats, smog of emerging, and stops heating when smog is gradually reduced to disappearance, removing paper scrap, by medicine porphyrize, crosses 160-200 mesh sieve;
2. by Cortex Phellodendri, Cacumen Platycladi, Rhizoma Imperatae and Rhizoma Coptidis section, be placed in container, add rice wine, moistening 4-6 hour;
3. Herba ajugae ciliatae (Herba Ajugae Ajuga ciliata Bge.), Fructus Forsythiae, Flos Magnoliae, Flos Chrysanthemi, Flos Lonicerae, Herba Houttuyniae and Herba Clinopodii are broken into coarse powder, add dissolved in purified water 20-30 minute, add step 2. gains, water extraction twice, each extraction 40-60 minute, merge extractive liquid;
4. by step 1. gained medicated powder join step 3. in gained extracting solution, stir 3-5 minute, adding second acid for adjusting pH is 3-4, and leave standstill 2-4 hour, remove precipitate, filtrate, by the charcoal treatment of 0.2%, obtains medicinal liquid 1;
5. polyglycolic acid is placed in container, add medicinal liquid 1 and dissolve 5-10 minute, be placed in homogenizer, add carboxymethyl chitosan, cumyl peroxide and sodium alginate, high-speed stirred 15-20 minute, add laurocapram, continue to stir 4-6 minute, froth breaking, makes spinning solution, leaves standstill 10-15 hour;
6. by spinning solution through 4-12mm SPINNERETS FOR MELT SPINNING spray webbing, the monofilament lines of the obtained different size that the water-bath of gained spray webbing fiber stretched, is washed to neutrality, carries out showering coloring agent, cold drying;
7. by 30-50 minute in step 6. gains immersion medical alcohol, carry out sterilizing, vacuum drying is packed, and obtains operation suture thread.
5. preparation method according to claim 4, is characterized in that: step is 1. preferred crosses 170-190 mesh sieve, is more preferably 180 mesh sieves.
6. preparation method according to claim 4, is characterized in that: step 2. preferably the consumption of rice wine be the 20%-30% of quality of medicinal material, the consumption being more preferably rice wine is 25% of quality of medicinal material.
7. preparation method according to claim 4, is characterized in that: step is 3. preferably each extracts 45-55 minute, is more preferably each extraction 50 minutes.
8. preparation method according to claim 4, is characterized in that: 4. step preferably adds second acid for adjusting pH is 3.3-3.7, is more preferably that to add second acid for adjusting pH be 3.5.
9. preparation method according to claim 4, is characterized in that: step 5. preferred rotating speed is 200 revs/min-300 revs/min, and being more preferably rotating speed is 250 revs/min.
10. preparation method according to claim 4, is characterized in that: 7. step preferably immerses 35-45 minute in medical alcohol, is more preferably and immerses in medical alcohol 40 minutes.
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| CN108096627A (en) * | 2017-12-26 | 2018-06-01 | 庞庆华 | A kind of suture of continuous and effective bactericidal |
| CN109224117A (en) * | 2018-10-11 | 2019-01-18 | 天津科技大学 | A kind of production method of the bacteria cellulose operation suture thread of antibacterial |
| CN110279899A (en) * | 2019-07-05 | 2019-09-27 | 王延英 | A kind of noninvasive eye tail promotion high molecular material mixed processing method |
| CN110302417A (en) * | 2019-06-18 | 2019-10-08 | 珠海稻田医疗科技有限公司 | A kind of antibacterial, biodegradable suture |
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