CN110302417A - A kind of antibacterial, biodegradable suture - Google Patents
A kind of antibacterial, biodegradable suture Download PDFInfo
- Publication number
- CN110302417A CN110302417A CN201910524428.9A CN201910524428A CN110302417A CN 110302417 A CN110302417 A CN 110302417A CN 201910524428 A CN201910524428 A CN 201910524428A CN 110302417 A CN110302417 A CN 110302417A
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- Prior art keywords
- suture
- parts
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- preparation
- chitosan
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention belongs to field of medical materials, a kind of antibacterial, biodegradable suture are disclosed, according to parts by weight, it is composed of the following components: 30-60 parts of chitosan, 40-80 parts of alcohol soluble protein, 5-20 parts of polycaprolactone, 1-10 parts of citric acid, 10-40 parts of Honegsukle flower P.E, 2-10 parts of glycerol.Compared with the existing technology, suture of the present invention has lasting good antibacterial effect, especially has good antibacterial effect to Escherichia coli and staphylococcus aureus, sterilizing rate is up to 99%；Suture biodegradability of the present invention is good, and 4-5 months i.e. degradable, is not easy to cause the allergic reaction of human body.
Description
Technical field
The invention belongs to field of medical materials, in particular to a kind of antibacterial, biodegradable suture.
Background technique
Suture generally uses during surgery, plays a significant role to promotion wound healing.It uses in the prior art
Suture can be divided into two classes, one kind is absorbable suture, and another kind of is the suture of nonabsorable.For can not
The suture of absorption will cause larger pain for patients during taking out stitches.Absorbable suture then has significantly
Reduce the advantage for pain of taking out stitches.After patient wound's healing, without removing suture, human body interior suction can be stayed in and incorporate solution.But
The suture degradation time that can voluntarily degrade in human body used in the prior art is long, occurs in human body anaphylactoid
Probability is big, and some sutures need special antibacterial agent to be handled can just play preferable antibacterial effect, and antibacterial effect
Not persistently, antibacterial agent enters after human body the rejection also easily caused with human body.
Therefore it provides a kind of handled without antibacterial agent, just there is antibacterial effect, and biodegradability is good in human body
It is good, be not easy to cause the suture of human allergy's reaction very it is necessary to.
Summary of the invention
In view of the deficiencies of the prior art, the present invention provides a kind of antibacterial, biodegradable suture.The medical seam
Zygonema is especially handled without antibacterial agent, and the suture itself just has antibacterial effect, and with good in human body
Biological degradability can quickly be absorbed by the body.
A kind of antibacterial, biodegradable suture, according to parts by weight, composed of the following components:
Preferably, a kind of antibacterial, biodegradable suture, according to parts by weight, composed of the following components:
It is further preferred that a kind of antibacterial, biodegradable suture, according to parts by weight, by following components group
At:
Preferably, the alcohol soluble protein is selected from least one of wheat gliadin or zeins.
It is further preferred that the alcohol soluble protein is selected from wheat gliadin.
Preferably, the chitosan is the deacetylated chitosan of 78-88%.
Preferably, the Honegsukle flower P.E is be 20-50% with volume fraction alcohol solution dipping 12-24 hours,
Then it filters, filtrate is taken to obtain, as Honegsukle flower P.E.
It is further preferred that the amount ratio of the honeysuckle and ethanol solution is 5-10g:100-200mL.
A kind of antibacterial, the preparation method of biodegradable suture, comprising the following steps:
(1) each component is weighed by formula ratio, alcohol soluble protein, polycaprolactone, Honegsukle flower P.E is mixed, be made mixed
Object A is closed, it is spare；
(2) by chitosan, citric acid, glycerol mix, be made mixture B, then be added mixture A, 600-800 turn/
It is stirred 30-60 minutes under minute, mixture C is made, it is spare；
(3) mixture C made from step (2) is added twin-screw extrude into carry out melting mixing again, squeezes out, then draws
It stretches, water cooling, pelletizing, it is dry, master batch is made, then master batch is subjected to melt spinning, drawn is twisted, and sterilizing obtains medical seam
Zygonema.
Preferably, the condition of the drying in step (3) is 1-2 hours dry at 40-60 DEG C.
Preferably, the temperature of the melting mixing in step (3) is 100-130 DEG C.
Preferably, the temperature of the melt spinning in step (3) is 150-165 DEG C.
Preferably, the sterilizing in step (3) is sterilized 20-40 minutes under the ultraviolet light of 250-300nm.
Stretching described in step (3), water cooling, pelletizing, the process of twisting are this field routine techniques.
Compared with the existing technology, beneficial effects of the present invention are as follows:
(1) suture of the present invention has lasting good antibacterial effect, especially to Escherichia coli and gold
Staphylococcus aureus has good antibacterial effect, and sterilizing rate is up to 99%.
(2) suture biodegradability of the present invention is good, and 4-5 months i.e. degradable, is not easy to cause human body
Allergic reaction.
Specific embodiment
In order to allow those skilled in the art that technical solution of the present invention is more clearly understood, now enumerate following embodiment into
Row explanation.It should be pointed out that following embodiment to the present invention claims protection scope do not constitute a limitation effect.
Embodiment 1
A kind of antibacterial, biodegradable suture, according to parts by weight, composed of the following components:
The alcohol soluble protein is wheat gliadin.
The chitosan is the deacetylated chitosan of 85-88%.
It is alcohol solution dipping 20 hours of 30% that the Honegsukle flower P.E, which is with volume fraction, then filters, takes filter
Liquid obtains, as Honegsukle flower P.E.
The amount ratio of the honeysuckle and ethanol solution is 8g:150mL.
A kind of antibacterial, the preparation method of biodegradable suture, comprising the following steps:
(1) each component is weighed by formula ratio, alcohol soluble protein, polycaprolactone, Honegsukle flower P.E is mixed, be made mixed
Object A is closed, it is spare；
(2) chitosan, citric acid, glycerol are mixed, mixture B is made, mixture A is then added, at 600 revs/min
Under be stirred 60 minutes, be made mixture C, it is spare；
(3) mixture C made from step (2) is added twin-screw extrude into carry out melting mixing again, squeezes out, then draws
It stretches, water cooling, pelletizing, it is dry, master batch is made, then master batch is subjected to melt spinning, drawn is twisted, and sterilizing obtains medical seam
Zygonema.
The condition of drying in step (3) is 1.5 hours dry at 50 DEG C.
The temperature of melting mixing in step (3) is 110 DEG C.
The temperature of melt spinning in step (3) is 165 DEG C.
Sterilizing in step (3) is sterilized 30 minutes under the ultraviolet light of 280-300nm.
Embodiment 2
A kind of antibacterial, biodegradable suture, according to parts by weight, composed of the following components:
The alcohol soluble protein is selected from wheat gliadin.
The chitosan is the deacetylated chitosan of 86-88%.
It is alcohol solution dipping 15 hours of 50% that the Honegsukle flower P.E, which is with volume fraction, then filters, takes filter
Liquid obtains, as Honegsukle flower P.E.
The amount ratio of the honeysuckle and ethanol solution is 10g:200mL.
A kind of antibacterial, the preparation method of biodegradable suture, comprising the following steps:
(1) each component is weighed by formula ratio, alcohol soluble protein, polycaprolactone, Honegsukle flower P.E is mixed, be made mixed
Object A is closed, it is spare；
(2) chitosan, citric acid, glycerol are mixed, mixture B is made, mixture A is then added, at 750 revs/min
Under be stirred 50 minutes, be made mixture C, it is spare；
(3) mixture C made from step (2) is added twin-screw extrude into carry out melting mixing again, squeezes out, then draws
It stretches, water cooling, pelletizing, it is dry, master batch is made, then master batch is subjected to melt spinning, drawn is twisted, and sterilizing obtains medical seam
Zygonema.
The condition of drying in step (3) is 1.5 hours dry at 60 DEG C.
The temperature of melting mixing in step (3) is 130 DEG C.
The temperature of melt spinning in step (3) is 160 DEG C.
Sterilizing in step (3) is sterilized 25 minutes under the ultraviolet light of 250-260nm.
Embodiment 3
A kind of antibacterial, biodegradable suture, according to parts by weight, composed of the following components:
The alcohol soluble protein is selected from wheat gliadin.
The chitosan is the deacetylated chitosan of 78-88%.
The Honegsukle flower P.E is be 20-50% with volume fraction alcohol solution dipping 12-24 hours, then mistake
Filter, takes filtrate to obtain, as Honegsukle flower P.E.
It is further preferred that the amount ratio of the honeysuckle and ethanol solution is 5-10g:100-200mL.
A kind of antibacterial, the preparation method of biodegradable suture, comprising the following steps:
(1) each component is weighed by formula ratio, alcohol soluble protein, polycaprolactone, Honegsukle flower P.E is mixed, be made mixed
Object A is closed, it is spare；
(2) chitosan, citric acid, glycerol are mixed, mixture B is made, mixture A is then added, at 700 revs/min
Under be stirred 50 minutes, be made mixture C, it is spare；
(3) mixture C made from step (2) is added twin-screw extrude into carry out melting mixing again, squeezes out, then draws
It stretches, water cooling, pelletizing, it is dry, master batch is made, then master batch is subjected to melt spinning, drawn is twisted, and sterilizing obtains medical seam
Zygonema.
The condition of drying in step (3) is 1 hour dry at 60 DEG C.
The temperature of melting mixing in step (3) is 120 DEG C.
The temperature of melt spinning in step (3) is 160 DEG C.
Sterilizing in step (3) is sterilized 35 minutes under the ultraviolet light of 280-300nm.
Comparative example 1
Compared with Example 2, the suture in comparative example 1 does not include Honegsukle flower P.E and alcohol soluble protein.Remaining
Component and preparation process are same as Example 2.
Comparative example 2
Compared with Example 2,20 parts of the suture chitosan in comparative example 2,40 parts of polycaprolactone, remaining component and
Preparation process is same as Example 2.
Comparative example 3
Compared with Example 2, by chitosan, lemon in the step of suture preparation process in comparative example 3 (2)
Acid, glycerol mixing, are made mixture B, mixture A are then added, is stirred under 300 revs/min 50 minutes, mixing is made
Object C, remaining component and preparation process are same as Example 2.
Product measure of merit
Suture that Example 1-3 and comparative example 1-3 are prepared and commercially available antibacterial medical suture are (no
Simultaneously containing chitosan and Honegsukle flower P.E), according to the detection method and standard testing medical sutures of QB/T 2591-2003
Line is to the sterilizing rate of Escherichia coli and staphylococcus aureus, and the results are shown in Table 1.
Table 1:
As it can be seen from table 1 the suture that 1-3 of the embodiment of the present invention is prepared is to Escherichia coli and golden yellow Portugal
The sterilizing rate of grape coccus, hence it is evident that the suture being prepared better than comparative example 1-3 is to Escherichia coli and Staphylococcus aureus
The sterilizing rate of bacterium, also superior to commercially available antibacterial medical suture to the sterilizing rate of Escherichia coli and staphylococcus aureus.
In addition, suture and commercially available antibacterial medical suture prepared by Example 2 (do not contain chitosan simultaneously
And Honegsukle flower P.E) wound close to small white mouse same section size suture, be observed continuously, it is prepared with embodiment 2
Silk sutures wound, just absorbed by mouse in 4-5 month suturees, and in wound healing process, and
It is good not occur allergic reactions phenomenon, the biodegradabilities such as unusual erythema.With commercially available antibacterial medical suture to 6-7
The moon is just absorbed, and in wound healing process, the allergic reactions phenomenon such as slight erythema occurs.
Claims (10)
1. a kind of antibacterial, biodegradable suture, which is characterized in that according to parts by weight, composed of the following components:
2. suture according to claim 1, which is characterized in that according to parts by weight, composed of the following components:
3. suture according to claim 1 or 2, which is characterized in that the chitosan is that 78-88% is deacetylated
Chitosan.
4. suture according to claim 1 or 2, which is characterized in that the alcohol soluble protein is selected from the molten egg of wheat alcohol
At least one of white or zeins.
5. suture according to claim 1 or 2, which is characterized in that the Honegsukle flower P.E is with volume point
Number is alcohol solution dipping honeysuckle 12-24 hours of 20-50%, then filters, filtrate is taken to obtain.
6. suture according to claim 5, which is characterized in that the amount ratio of the honeysuckle and ethanol solution is
5-10g:100-200mL。
7. a kind of preparation method of suture according to claim 1 to 6, which is characterized in that including with
Lower step:
(1) each component is weighed by formula ratio, alcohol soluble protein, polycaprolactone, Honegsukle flower P.E is mixed, mixture is made
A, it is spare；
(2) chitosan, citric acid, glycerol are mixed, mixture B is made, the mixture A of step (1) preparation, stirring is then added
Mixture C is made in mixing, spare；
(3) mixture C made from step (2) is subjected to melting mixing again, then stretched, water cooling, pelletizing, it is dry, master batch is made,
Master batch is subjected to melt spinning again, drawn is twisted, and sterilizing obtains suture.
8. preparation method according to claim 7, which is characterized in that being stirred in step (2) is in 600-800
It is stirred under rev/min 30-60 minutes.
9. preparation method according to claim 7, which is characterized in that the temperature of the melting mixing in step (3) is 100-
130℃；The temperature of melt spinning in step (3) is 150-165 DEG C；The condition of drying in step (3) is at 40-60 DEG C
It is 1-2 hours dry.
10. preparation method according to claim 7, which is characterized in that the sterilizing in step (3) is in 250-300nm
Under ultraviolet light, sterilize 20-40 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910524428.9A CN110302417A (en) | 2019-06-18 | 2019-06-18 | A kind of antibacterial, biodegradable suture |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910524428.9A CN110302417A (en) | 2019-06-18 | 2019-06-18 | A kind of antibacterial, biodegradable suture |
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| CN110302417A true CN110302417A (en) | 2019-10-08 |
Family
ID=68076736
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| CN201910524428.9A Pending CN110302417A (en) | 2019-06-18 | 2019-06-18 | A kind of antibacterial, biodegradable suture |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111298184A (en) * | 2020-04-20 | 2020-06-19 | 张丙起 | Biodegradable drug-loaded nanofiber medical bandage for burn department and preparation method thereof |
| CN114470301A (en) * | 2021-12-22 | 2022-05-13 | 南京财经大学 | Preparation method of soybean polypeptide absorbable medical suture line |
| CN114752091A (en) * | 2022-03-25 | 2022-07-15 | 中国科学院兰州化学物理研究所 | Preparation method of zein/honeysuckle extract composite antibacterial preservative film |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111298184A (en) * | 2020-04-20 | 2020-06-19 | 张丙起 | Biodegradable drug-loaded nanofiber medical bandage for burn department and preparation method thereof |
| CN114470301A (en) * | 2021-12-22 | 2022-05-13 | 南京财经大学 | Preparation method of soybean polypeptide absorbable medical suture line |
| CN114752091A (en) * | 2022-03-25 | 2022-07-15 | 中国科学院兰州化学物理研究所 | Preparation method of zein/honeysuckle extract composite antibacterial preservative film |
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