CN107519527A - A kind of medical absorbable suture with antibiotic property and preparation method thereof - Google Patents
A kind of medical absorbable suture with antibiotic property and preparation method thereof Download PDFInfo
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- CN107519527A CN107519527A CN201710847872.5A CN201710847872A CN107519527A CN 107519527 A CN107519527 A CN 107519527A CN 201710847872 A CN201710847872 A CN 201710847872A CN 107519527 A CN107519527 A CN 107519527A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
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Abstract
The present invention discloses a kind of medical absorbable suture with antibiotic property and preparation method thereof.The component that the operation suture thread includes following weight parts is prepared：90~110 parts of cereal gliadin, 415~440 parts of ethanol water, 10~100 parts of chitosan, 54~71 parts of oleic acid, 5~10 parts of glycerine.The preparation method includes cereal gliadin adding ethanol water stirring and dissolving；Oleic acid is added into above-mentioned mixed liquor constant temperature to stir to solution homogeneous transparent；Chitosan is added into above-mentioned mixing liquid, 60~70 DEG C of 40~90min of insulated and stirred, is then cooled to room temperature at normal temperatures and pressures；By it is above-mentioned be fitted into silk stock solution in yarn-plying apparatus and squeeze into coagulating bath while solidification while stretch；Above-mentioned silk thread is applied into glycerine, drying at room temperature through surface and sterilized, obtains the operation suture thread.The present invention has more preferable biocompatibility, degradability, had no toxic side effect, antibacterial, avoids inflammation and wound infection.
Description
Technical field
The invention belongs to technical field of medical instruments, and in particular to one kind have more preferable biocompatibility, degradability,
Have no toxic side effect, antibacterial, avoid medical absorbable suture with antibiotic property of inflammation and wound infection and preparation method thereof.
Background technology
Operation suture thread be it is a kind of for body operation suture linear material, from the point of view of Materials, experienced silk thread,
Catgut, chemical synthesis line, pure-natural collagen suture, are divided into absorbable thread and nonabsorable line.Existing operation stitching
Line requirement：Enough intensity and retractility can be kept during Wound healing, should also be able to elongation to adapt to wound water
It is swollen；Do not produce inflammation；Nonirritant or pathogenic possibility；The processing such as easy to dye, sterilizing, sterilization；Knot securely can be formed；
It is easy to make, cheap, can largely produce.Other the more important is exactly the absorbability of operation suture thread so that suture
Can voluntarily degrade absorption after Wound healing, not stay foreign matter.But the suture of traditional nonabsorable meeting intense stimulus otch
Inflammatory reaction, influences the healing quality of otch, and absorbable suture can also produce a small amount of scar.
It is the most common clinic of surgery that surgical incision skin structure infections, inflammatory, which ooze out that even otch skin splits etc.,
One of problem.Suture is present in incision tissue as a kind of foreign matter, skin histology is produced inflammatory reaction, sutured
Wound be highly susceptible to bacterium infection in body surrounding environment.In addition, suture is the passage that bacterium enters operative incision,
Easily absorption and harbor bacteria, add the incidence of surgical site infection.Therefore, inappropriate operation suture thread not only influences
Wound healing, pain is brought to sufferer, while also increase the financial burden of patient or even society.If suture has antibacterial
Property, bacterial adsorption can be prevented, by bacterial resistant within the specific limits not with Wound contact, inflammation and thin can be avoided to greatest extent
The generation of bacterium infection, therefore the operation suture thread with antibiotic property is developed with important clinical value.
The content of the invention
The first object of the present invention be to provide it is a kind of have more preferable biocompatibility, degradability, have no toxic side effect,
Antibacterial, avoid the medical absorbable suture with antibiotic property of inflammation and wound infection；Second purpose is to provide one kind in fact
Existing first purpose has the medical absorbable suture preparation method of antibiotic property.
What the first object of the present invention was realized in：Component including following weight parts is prepared：
90~110 parts of cereal gliadin,
415~440 parts of ethanol water,
10~100 parts of chitosan,
54~71 parts of oleic acid,
5~10 parts of glycerine.
What the second object of the present invention was realized in：Prepared including alcohol soluble protein dissolving, mixing oleic acid, into silk stock solution,
Prepare, post-processing step, comprise the following steps that into silk：
A, alcohol soluble protein dissolves：Cereal gliadin is added in ethanol water, stirs to most alcohol soluble protein and dissolves, obtain
To alcohol soluble protein mixed liquor；
B, oleic acid is mixed：Oleic acid is added in above-mentioned alcohol soluble protein mixed liquor, with 500~700rpm/min 50~70 DEG C of speed
Constant temperature is stirred to solution homogeneous transparent, obtains mixing liquid；
C, prepared into silk stock solution：Chitosan is added into above-mentioned mixing liquid, under 60~70 DEG C of heat-retaining conditions, with 500~
700rpm/min speed stirs 40~90min, is then cooled to room temperature at normal temperatures and pressures, obtains into silk stock solution；
D, prepared into silk：It is fitted into above-mentioned into silk stock solution in yarn-plying apparatus, coagulating bath will be squeezed into silk stock solution by yarn-plying apparatus
It is middle to be stretched in solidification, obtain silk thread；
E, post-process：Above-mentioned silk thread is applied into glycerine, drying at room temperature through surface and sterilized, is obtained described absorbable with antibiotic property
Operation suture thread.
Chitosan is a kind of polysaccharide, comes from the shrimp shell crab shell after seafood eats, has unique antibacterial action, biology can
Degrade, be green.Chitosan can be dissolved in water, be widely used in the fields such as food, medical science, nutrition, have reduce cholesterol,
A variety of effectiveness such as residual heavy metal in antibacterial, adsorbent.
The present invention has the advantages that compared with prior art：
1st, suture of the invention is the absorbable operation stitching prepared using natural polymer cereal gliadin and chitosan
Line, contrast other animality sources and synthetic material, have formability is good, the high and more preferable biocompatibility of stability, can
Degradability, human body cell can be very good to adhere in suture and breed, and can promote wound healing, eliminate scar；
2nd, the cereal gliadin and chitosan that suture of the invention uses are cheap, wide material sources, and nontoxic edible is raw
Biodegradable, bio-compatible, have no toxic side effect, being advantageous to degrade in human body absorbs；
3rd, suture of the invention prepares bactericidal properties medical absorbable suture using chitosan, can stop that bacterium enters wound
Mouthful, avoid the generation of inflammation and wound infection；
4th, suture of the invention can increase the slickness and stability of suture, reduce tissue and drag through surface spraying glycerine
Drag, reduce the pain brought during suture to patient；
5th, preparation method of the invention is simple and easy, suitable for industrial production.
Embodiment
With reference to embodiment, the present invention is further illustrated, but the present invention is not any limitation as in any way,
Based on present invention teach that any changes and modifications made, belong to protection scope of the present invention.
The medical absorbable suture with antibiotic property of the present invention, including the component of following weight parts are prepared：
90~110 parts of cereal gliadin,
415~440 parts of ethanol water,
10~100 parts of chitosan,
54~71 parts of oleic acid,
5~10 parts of glycerine.
The cereal gliadin is zeins, kafirin, one kind in wheat gliadin or appointed
Meaning combination.
Volume fraction of ethanol is 72~90% in the ethanol water.
The chitosan is 75~90% deacetylated chitosans.
The density of the oleic acid is 0.891g/ml.
The density of the glycerine is 1.2633g/ml.
The preparation method of the medical absorbable suture with antibiotic property of the present invention, including alcohol soluble protein dissolving, mixing
Oleic acid, into silk stock solution prepare, into silk prepare, post-processing step, comprise the following steps that：
A, alcohol soluble protein dissolves：Cereal gliadin is added in ethanol water, stirs to most alcohol soluble protein and dissolves, obtain
To alcohol soluble protein mixed liquor；
B, oleic acid is mixed：Oleic acid is added in above-mentioned alcohol soluble protein mixed liquor, with 500~700rpm/min 50~70 DEG C of speed
Constant temperature is stirred to solution homogeneous transparent, obtains mixing liquid；
C, prepared into silk stock solution：Chitosan is added into above-mentioned mixing liquid, under 60~70 DEG C of heat-retaining conditions, with 500~
700rpm/min speed stirs 40~90min, is then cooled to room temperature at normal temperatures and pressures, obtains into silk stock solution；
D, prepared into silk：It is fitted into above-mentioned into silk stock solution in yarn-plying apparatus, coagulating bath will be squeezed into silk stock solution by yarn-plying apparatus
It is middle to be stretched in solidification, obtain silk thread；
E, post-process：Above-mentioned silk thread is applied into glycerine, drying at room temperature through surface and sterilized, is obtained described absorbable with antibiotic property
Operation suture thread.
Cereal gliadin concentration is 180~240mg/ml in the alcohol soluble protein mixed liquor of the step A, the step B
Mixing liquid in the volume fraction of oleic acid be 6~8%, the concentration into chitosan in silk stock solution of the step C for 20~
200mg/ml。
The aperture of the spinning head of yarn-plying apparatus is 0.02~0.1mm in the D steps.
In the D steps coagulating bath be the NaHO containing 0~20% percentage by weight ice-water bath, the solution of the ice-water bath
Temperature is 0 DEG C.
Step A stirring and dissolving at normal temperatures and pressures, pass through magnetic stirrer in the step B.
The colouring agent of the parts by weight of silk thread elder generation showering 5~10 and dry or dry in the E steps, then again surface apply it is sweet
Oil.
The alcohol soluble protein mixed liquor via hole diameter obtained in the step A is 0.45 μm of filtering with microporous membrane.
Embodiment 1
1st, under normal temperature and pressure, 10g zeins is weighed, is dissolved in 50ml 80%（About 43g, the g/ml of density 0.85932）'s
In ethanol-water solution, stirred to most zeins and dissolved with glass bar, obtain zeins mixed liquor；
2nd, by 7ml oleic acid（About 6.24g, the g/ml of density 0.891）Add in above-mentioned zeins mixed liquor, 50~70
Stirred in DEG C constant temperature blender with magnetic force with 600rpm/min speed to solution homogeneous transparent, obtain mixing liquid；
3rd, into above-mentioned mixing liquid add 5g chitosan, under 60~70 DEG C of heat-retaining conditions, in constant temperature blender with magnetic force with
600rpm/min speed stirring 60min, is then cooled to room temperature, obtains into silk stock solution at normal temperatures and pressures；
4th, be fitted into above-mentioned into silk stock solution in yarn-plying apparatus, by yarn-plying apparatus aperture be 0. 08mm, the spinning head in 30 holes will be into
Silk stock solution is squeezed into 0 DEG C of NaHO containing 10% percentage by weight ice-water bath and stretched in solidification, obtains diameter 0.08mm silk
Line；
5th, above-mentioned wire surface is sprayed into 0.5g glycerine, drying at room temperature and sterilized, obtained described absorbable with antibiotic property
Operation suture thread.
Embodiment 2
1st, under normal temperature and pressure, 9g wheat gliadin is weighed, is dissolved in the 89.8% of 50ml（About 41.5g, the g/ of density 0.82992
ml）Ethanol-water solution in, with glass bar stir to most wheat gliadin dissolve, obtain wheat gliadin mixing
Liquid；
2nd, by 8ml oleic acid（About 7.12g, the g/ml of density 0.891）Add in above-mentioned wheat gliadin mixed liquor, 50~70
Stirred in DEG C constant temperature blender with magnetic force with 500rpm/min speed to solution homogeneous transparent, obtain mixing liquid；
3rd, into above-mentioned mixing liquid add 10g chitosan, under 60~70 DEG C of heat-retaining conditions, in constant temperature blender with magnetic force with
500rpm/min speed stirring 90min, is then cooled to room temperature, obtains into silk stock solution at normal temperatures and pressures；
4th, be fitted into above-mentioned into silk stock solution in yarn-plying apparatus, by yarn-plying apparatus aperture be 0. 1mm, the spinning head in 30 holes will be into
Silk stock solution is squeezed into 0 DEG C of NaHO containing 5% percentage by weight ice-water bath and stretched in solidification, obtains diameter 0.1mm silk thread；
5th, above-mentioned wire surface is sprayed into 0.7g glycerine, drying at room temperature and sterilized, obtained described absorbable with antibiotic property
Operation suture thread.
Embodiment 3
1st, under normal temperature and pressure, 5g wheat gliadins and 6g zeins are weighed, is dissolved in 50ml 84% respectively（About 42.4g,
The g/ml of density 0.84791）Ethanol-water solution in, with glass bar stir to most alcohol soluble protein dissolve, obtain the molten egg of alcohol
White mixed liquor；
2nd, by 7ml oleic acid（About 6.24g, the g/ml of density 0.891）Add in above-mentioned alcohol soluble protein mixed liquor, in 50~70 DEG C of perseverances
Stirred in warm magnetic stirring apparatus with 700rpm/min speed to solution homogeneous transparent, obtain mixing liquid；
3rd, into above-mentioned mixing liquid add 8g chitosan, under 60~70 DEG C of heat-retaining conditions, in constant temperature blender with magnetic force with
700rpm/min speed stirring 65min, is then cooled to room temperature, obtains into silk stock solution at normal temperatures and pressures；
4th, be fitted into above-mentioned into silk stock solution in yarn-plying apparatus, by yarn-plying apparatus aperture be 0. 02mm, the spinning head in 30 holes will be into
Silk stock solution is squeezed into 0 DEG C of NaHO containing 20% percentage by weight ice-water bath and stretched in solidification, obtains diameter 0.02mm silk
Line；
5th, above-mentioned wire surface is sprayed into 1g glycerine, drying at room temperature and sterilized, obtain the absorbable hand with antibiotic property
Art suture.
Embodiment 4
1st, under normal temperature and pressure, 10g kafirins are weighed, are dissolved in 50ml 72%（About 44g, the g/ml of density 0.88051）Second
In alcohol-water solution, stirred to most kafirin and dissolved with glass bar, obtain kafirin mixed liquor；
2nd, by 6ml oleic acid（About 5.35g, the g/ml of density 0.891）Add in above-mentioned kafirin mixed liquor, 50~70
Stirred in DEG C constant temperature blender with magnetic force with 600rpm/min speed to solution homogeneous transparent, obtain mixing liquid；
3rd, into above-mentioned mixing liquid add 1g chitosan, under 60~70 DEG C of heat-retaining conditions, in constant temperature blender with magnetic force with
600rpm/min speed stirring 40min, is then cooled to room temperature, obtains into silk stock solution at normal temperatures and pressures；
4th, be fitted into above-mentioned into silk stock solution in yarn-plying apparatus, by yarn-plying apparatus aperture be 0. 05mm, the spinning head in 30 holes will be into
Silk stock solution is squeezed into 0 DEG C of ice-water bath and stretched in solidification, obtains diameter 0.05mm silk thread；
5th, by above-mentioned silk thread elder generation showering 0.5g colouring agent and dry, then surface spraying 1g glycerine, drying at room temperature and go out again
Bacterium, obtain the medical absorbable suture with antibiotic property.
Embodiment 5
1st, under normal temperature and pressure, 5g kafirins and 4g zeins are weighed, is dissolved in 50ml 78% respectively（About
43.2g, the g/ml of density 0.8648）Ethanol-water solution in, with glass bar stir to most alcohol soluble protein dissolve, obtain alcohol
Molten mixed liquid of protein；
2nd, by 8ml oleic acid（About 7.12g, the g/ml of density 0.891）Add in above-mentioned alcohol soluble protein mixed liquor, in 50~70 DEG C of perseverances
Stirred in warm magnetic stirring apparatus with 500rpm/min speed to solution homogeneous transparent, obtain mixing liquid；
3rd, into above-mentioned mixing liquid add 3g chitosan, under 60~70 DEG C of heat-retaining conditions, in constant temperature blender with magnetic force with
500rpm/min speed stirring 50min, is then cooled to room temperature, obtains into silk stock solution at normal temperatures and pressures；
4th, be fitted into above-mentioned into silk stock solution in yarn-plying apparatus, by yarn-plying apparatus aperture be 0. 08mm, the spinning head in 30 holes will be into
Silk stock solution is squeezed into 0 DEG C of NaHO containing 15% percentage by weight ice-water bath and stretched in solidification, obtains diameter 0.08mm silk
Line；
5th, by above-mentioned silk thread elder generation showering 1g colouring agent and dry, then surface spraying 0.8g glycerine, drying at room temperature and go out again
Bacterium, obtain the medical absorbable suture with antibiotic property.
Embodiment 6
1st, under normal temperature and pressure, 5g kafirins and 5g wheat gliadins are weighed, is dissolved in 50ml 80% respectively（About
43g, the g/ml of density 0.85932）Ethanol-water solution in, with glass bar stir to most alcohol soluble protein dissolve, obtain alcohol
Molten mixed liquid of protein；
2nd, by 7ml oleic acid（About 6.24g, the g/ml of density 0.891）Add in above-mentioned alcohol soluble protein mixed liquor, in 50~70 DEG C of perseverances
Stirred in warm magnetic stirring apparatus with 600rpm/min speed to solution homogeneous transparent, obtain mixing liquid；
3rd, into above-mentioned mixing liquid add 7g chitosan, under 60~70 DEG C of heat-retaining conditions, in constant temperature blender with magnetic force with
600rpm/min speed stirring 80min, is then cooled to room temperature, obtains into silk stock solution at normal temperatures and pressures；
4th, be fitted into above-mentioned into silk stock solution in yarn-plying apparatus, by yarn-plying apparatus aperture be 0. 1mm, the spinning head in 30 holes will be into
Silk stock solution is squeezed into 0 DEG C of NaHO containing 10% percentage by weight ice-water bath and stretched in solidification, obtains diameter 0.1mm silk thread；
5th, by above-mentioned silk thread elder generation showering 0.8g colouring agent and dry, then surface spraying 1g glycerine, drying at room temperature and go out again
Bacterium, obtain the medical absorbable suture with antibiotic property.
Claims (10)
- A kind of 1. medical absorbable suture with antibiotic property, it is characterised in that component including following weight parts prepare and Into：90~110 parts of cereal gliadin,415~440 parts of ethanol water,10~100 parts of chitosan,54~71 parts of oleic acid,5~10 parts of glycerine.
- 2. there is the medical absorbable suture of antibiotic property according to claim 1, it is characterised in that the molten egg of cereal alcohol It is zeins, kafirin, one kind or any combination in wheat gliadin in vain.
- 3. there is the medical absorbable suture of antibiotic property according to claim 1, it is characterised in that the ethanol water Middle volume fraction of ethanol is 72~90%.
- 4. there is the medical absorbable suture of antibiotic property according to claim 1, it is characterised in that the chitosan is 75 ~90% deacetylated chitosan.
- A kind of 5. preparation method of the medical absorbable suture with antibiotic property described in claim 1, it is characterised in that including Alcohol soluble protein dissolving, oleic acid is mixed, is prepared into silk stock solution, is prepared into silk, post-processing step, comprised the following steps that：A, alcohol soluble protein dissolves：Cereal gliadin is added in ethanol water, stirs to most alcohol soluble protein and dissolves, obtain To alcohol soluble protein mixed liquor；B, oleic acid is mixed：Oleic acid is added in above-mentioned alcohol soluble protein mixed liquor, with 500~700rpm/min 50~70 DEG C of speed Constant temperature is stirred to solution homogeneous transparent, obtains mixing liquid；C, prepared into silk stock solution：Chitosan is added into above-mentioned mixing liquid, under 60~70 DEG C of heat-retaining conditions, with 500~ 700rpm/min speed stirs 40~90min, is then cooled to room temperature at normal temperatures and pressures, obtains into silk stock solution；D, prepared into silk：It is fitted into above-mentioned into silk stock solution in yarn-plying apparatus, coagulating bath will be squeezed into silk stock solution by yarn-plying apparatus It is middle to be stretched in solidification, obtain silk thread；E, post-process：Above-mentioned silk thread is applied into glycerine, drying at room temperature through surface and sterilized, is obtained described absorbable with antibiotic property Operation suture thread.
- 6. the preparation method of the medical absorbable suture with antibiotic property according to claim 5, it is characterised in that the A Cereal gliadin concentration is 180~240mg/ml in the alcohol soluble protein mixed liquor of step, oleic acid in the mixing liquid of the step B Volume fraction be 6~8%, the concentration into chitosan in silk stock solution of the step C is 20~200mg/ml.
- 7. the preparation method of the medical absorbable suture with antibiotic property according to claim 5, it is characterised in that the D The aperture of the spinning head of yarn-plying apparatus is 0.02~0.1mm in step.
- 8. the preparation method of the medical absorbable suture with antibiotic property according to claim 5 or 7, it is characterised in that institute The ice-water bath that coagulating bath in D steps is the NaHO containing 0~20% percentage by weight is stated, the solution temperature of the ice-water bath is 0 DEG C.
- 9. the preparation method of the medical absorbable suture with antibiotic property according to claim 5, it is characterised in that the A Step stirring and dissolving at normal temperatures and pressures, pass through magnetic stirrer in the step B.
- 10. the preparation method of the medical absorbable suture with antibiotic property according to claim 5, it is characterised in that described The colouring agent of the parts by weight of silk thread elder generation showering 5~10 and dry or dry in E steps, then surface applies glycerine again.
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| CN201710847872.5A CN107519527A (en) | 2017-09-19 | 2017-09-19 | A kind of medical absorbable suture with antibiotic property and preparation method thereof |
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| CN201710847872.5A CN107519527A (en) | 2017-09-19 | 2017-09-19 | A kind of medical absorbable suture with antibiotic property and preparation method thereof |
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| CN110302417A (en) * | 2019-06-18 | 2019-10-08 | 珠海稻田医疗科技有限公司 | A kind of antibacterial, biodegradable suture |
| CN110354298A (en) * | 2019-07-26 | 2019-10-22 | 南京聚屹新材料有限公司 | It is a kind of to be cross-linked in situ silver nanowires/polycaprolactone operation suture thread preparation method |
| CN110755671A (en) * | 2019-09-29 | 2020-02-07 | 姜之全 | Barb knotting-free reinforced suture line and preparation method thereof |
| CN111319214A (en) * | 2020-03-11 | 2020-06-23 | 单县华宇缝合制品有限公司 | Collagen line preparation equipment and preparation process thereof |
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Application publication date: 20171229 |