CN108096627A - A kind of suture of continuous and effective bactericidal - Google Patents
A kind of suture of continuous and effective bactericidal Download PDFInfo
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- CN108096627A CN108096627A CN201711436336.2A CN201711436336A CN108096627A CN 108096627 A CN108096627 A CN 108096627A CN 201711436336 A CN201711436336 A CN 201711436336A CN 108096627 A CN108096627 A CN 108096627A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention discloses a kind of suture of continuous and effective bactericidal, is configured by the raw material of following parts by weight：80 100 parts by weight of modification of chitosan, 13 parts by weight of polyvinylpyrrolidone, 12 parts by weight of polyglycolic acid, 0.05 0.1 parts by weight of syringic acid, 0.1 0.5 parts by weight of sodium alginate, 0.5 2 parts by weight of glucose, 1.5 3 parts by weight of Seabuckthorn Oil；Wherein, the preparation method of modification of chitosan is：Sorbierite is taken to be dissolved into anhydrous ether solution, adds thionyl chloride, the acetic acid solution of shell adding glycan after reaction is stood after reaction, is added in excessive precipitating reagent, is precipitated product, purifies drying, obtain modification of chitosan.The present invention is by being modified chitosan, improve the bacteria resistance and structural strength of the chitosan as soluble suture, suture of the present invention keeps mild state with tissue contact site, reduce suture stimulates caused by tissue, the performance pharmacological action that suture can be permanently effective simultaneously, reduces the infected probability sewed up a wound.
Description
Technical field
The invention belongs to medical material manufacture field, specifically, being related to a kind of medical sutures of continuous and effective bactericidal
Line.
Background technology
Suture refers in surgical operation, for wound suture hemostasis and a kind of special use of tissue apposition
Line, according to the biodegradability of suture, suture can be mainly divided into nonabsorable line and two major class of absorbable thread, now
Suture be mainly absorbable thread.
Absorbable thread is broadly divided into natural fiber class and synthesis high score subclass, and absorbable thread need not be torn open after being sutured
Line, suture can degrade within the regular hour in itself, and very light without scar or scar at the stitch of line, more beautiful after use
It sees, very convenient practicality, also therefore has obtained relatively broad application, but suture, after sewing up a wound, wound compares appearance
It is easily red and swollen or swelling is generated because of inflammation, at this moment if suture does not have enough elasticity, suture site will due to
Stitch occurs to slide and generates pain, and worry is brought for injury, in order to solve the problems, such as this, provides a kind of continuous and effective sterilization suppression
The suture of bacterium.The present invention provides following technical schemes.
The content of the invention
It is an object of the invention to provide a kind of suture of continuous and effective bactericidal, mechanical performances of the present invention
It is good, and with good antibiotic and sterilizing effect, there is good compatibility with biological tissue.
The purpose of the present invention can be achieved through the following technical solutions：
A kind of suture of continuous and effective bactericidal, is configured by the raw material of following parts by weight：Modified shell gathers
Sugared 80-100 parts by weight, polyvinylpyrrolidone 1-3 parts by weight, polyglycolic acid 1-2 parts by weight, syringic acid 0.05-0.1 weight
Part, sodium alginate 0.1-0.5 parts by weight, glucose 0.5-2 parts by weight, Seabuckthorn Oil 1.5-3 parts by weight.
Wherein, the preparation method of modification of chitosan is：Sorbierite is taken to be dissolved into anhydrous ether solution, adds in thionyl chloride
Solution A is obtained, the acetic acid solution of chitosan is added in after reaction, it is rear after reaction to stand, excessive precipitating reagent is added in, precipitates product,
Drying is purified, obtains modification of chitosan.
Preferably, the preparation method of modification of chitosan is：Sorbierite is taken to add in anhydrous ether solution after dissolving, is gradually added
Enter thionyl chloride, obtain solution A, stirring makes thionyl chloride carry out ultrasonication after being completely dissolved, and flows back, and cooling slowly adds
The acetic acid solution of chitosan, ultrasonication, suction filtration obtains sediment, then impregnates sediment with soak, is taken out after immersion
Filter obtains filter cake, extract in filter cake to be dried in vacuo after product with soxhlet extraction method and obtains product.
Preferably, the preparation method of modification of chitosan is：Sorbierite is added in anhydrous ether solution and is dissolved, is gradually added into
Thionyl chloride obtains solution A, and after sulfoxide to be chlorinated is completely dissolved, with ultrasonication 10-15min, reflux is cooled to 0-15
Degree Celsius, the acetic acid solution of slow shell adding glycan, keep mixed solution temperature in the range of 0-15 degrees Celsius ultrasound 60-
80min stands 20-24h at a temperature of 0-15 degrees Celsius, adds in excessive precipitating reagent, and suction filtration obtains sediment, soaked with soak
It is filtered after bubble sediment 20-24h and obtains filter cake, filter cake is dissolved into acetone, soxhlet extraction 20-24h, vacuum drying is changed
Property chitosan.
Further, the precipitating reagent is acetone.
Further, the soak is absolute ethyl alcohol and the mixture of anhydrous ether, wherein absolute ethyl alcohol and anhydrous second
The volume ratio of ether is 7:3.
Further, sorbierite, thionyl chloride, the w/v (g/ml) of anhydrous ether are 3 in the solution A:5:
50~70.
Further, in the acetic acid solution of chitosan, the w/v of chitosan and acetic acid is 1~1.5:50.
Above-mentioned " acetone ", the dosage of " soak " do not limit, on the premise of it can reach effect specific dosage according to
Output is determined with production status.
Beneficial effects of the present invention：The present invention is improved by being modified to chitosan as soluble medical sutures
The bacteria resistance and structural strength of the chitosan of line, the sodium alginate added in of the invention make suture and people with Seabuckthorn Oil
Body tissue contact site keeps mild state, and reduce suture stimulates caused by tissue, while using polyglycolic acid as load
Body, polyvinylpyrrolidone are corrosion inhibiter, enable the performance pharmacological action that syringic acid is permanently effective, reduce sew up a wound by
Probability is infected, accelerates healing rate and healing quality.
Specific embodiment
The technical solution in the embodiment of the present invention will be clearly and completely described below, it is clear that described implementation
Example is only part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, this field is common
All other embodiment that technical staff is obtained without creative efforts belongs to the model that the present invention protects
It encloses.
Embodiment 1：
A kind of suture of continuous and effective bactericidal, is configured by the raw material of following parts by weight：Modified shell gathers
Sugared 80 parts by weight, 2 parts by weight of polyvinylpyrrolidone, 2 parts by weight of polyglycolic acid, 0.08 parts by weight of syringic acid, sodium alginate
0.3 parts by weight, 0.5 parts by weight of glucose, 2 parts by weight of Seabuckthorn Oil.
Preferably, the preparation method of modification of chitosan is：Sorbierite is added in anhydrous ether solution and is dissolved, is gradually added into
Thionyl chloride obtains solution A, and after sulfoxide to be chlorinated is completely dissolved, with ultrasonication 12min, it is Celsius to be cooled to 0-15 for reflux
Degree, the acetic acid solution of slow shell adding glycan, keep mixed solution temperature in the range of 0-15 degrees Celsius ultrasound 60min,
It is stood at a temperature of 0-15 degrees Celsius for 24 hours, adds in excessive propanone, suction filtration obtains sediment, impregnates sediment for 24 hours with soak
It filters afterwards and obtains filter cake, filter cake is dissolved into acetone, for 24 hours, vacuum drying obtains modification of chitosan to soxhlet extraction.
Wherein, the soak is the mixture of absolute ethyl alcohol and anhydrous ether, wherein absolute ethyl alcohol and anhydrous ether
Volume ratio is 7:3.
Wherein, sorbierite, thionyl chloride, the w/v (g/ml) of anhydrous ether are 3 in the solution A:5:50.
Wherein, in the acetic acid solution of chitosan, the w/v of chitosan and acetic acid is 1.5:50.
Embodiment 2：
A kind of suture of continuous and effective bactericidal, is configured by the raw material of following parts by weight：Modified shell gathers
Sugared 100 parts by weight, 2 parts by weight of polyvinylpyrrolidone, 2 parts by weight of polyglycolic acid, 0.1 parts by weight of syringic acid, sodium alginate 0.4
Parts by weight, 2 parts by weight of glucose, 3 parts by weight of Seabuckthorn Oil.
Preferably, the preparation method of modification of chitosan is：Sorbierite is added in anhydrous ether solution and is dissolved, is gradually added into
Thionyl chloride obtains solution A, and after sulfoxide to be chlorinated is completely dissolved, with ultrasonication 15min, it is Celsius to be cooled to 0-15 for reflux
Degree, the acetic acid solution of slow shell adding glycan, keep mixed solution temperature in the range of 0-15 degrees Celsius ultrasound 70min,
23h is stood at a temperature of 0-15 degrees Celsius, adds in excessive propanone, suction filtration obtains sediment, impregnates sediment 23h with soak
It filters afterwards and obtains filter cake, filter cake is dissolved into acetone, soxhlet extraction 23h, vacuum drying obtains modification of chitosan.
Wherein, the soak is the mixture of absolute ethyl alcohol and anhydrous ether, wherein absolute ethyl alcohol and anhydrous ether
Volume ratio is 7:3.
Wherein, sorbierite, thionyl chloride, the w/v (g/ml) of anhydrous ether are 3 in the solution A:5:60.
Wherein, in the acetic acid solution of chitosan, the w/v of chitosan and acetic acid is 1:50.
Embodiment 3：
A kind of suture of continuous and effective bactericidal, is configured by the raw material of following parts by weight：Modified shell gathers
Sugared 90 parts by weight, 1.5 parts by weight of polyvinylpyrrolidone, 2 parts by weight of polyglycolic acid, 0.08 parts by weight of syringic acid, sodium alginate
0.4 parts by weight, 1 parts by weight of glucose, 2.5 parts by weight of Seabuckthorn Oil.
Preferably, the preparation method of modification of chitosan is：Sorbierite is added in anhydrous ether solution and is dissolved, is gradually added into
Thionyl chloride obtains solution A, and after sulfoxide to be chlorinated is completely dissolved, with ultrasonication 14min, it is Celsius to be cooled to 0-15 for reflux
Degree, the acetic acid solution of slow shell adding glycan, keep mixed solution temperature in the range of 0-15 degrees Celsius ultrasound 70min,
22h is stood at a temperature of 0-15 degrees Celsius, adds in excessive propanone, suction filtration obtains sediment, impregnates sediment 22h with soak
It filters afterwards and obtains filter cake, filter cake is dissolved into acetone, soxhlet extraction 22h, vacuum drying obtains modification of chitosan.
Wherein, the soak is the mixture of absolute ethyl alcohol and anhydrous ether, wherein absolute ethyl alcohol and anhydrous ether
Volume ratio is 7:3.
Wherein, sorbierite, thionyl chloride, the w/v (g/ml) of anhydrous ether are 3 in the solution A:5:70.
Wherein, in the acetic acid solution of chitosan, the w/v of chitosan and acetic acid is 1.5:50.
Present invention disclosed above preferred embodiment is only intended to help to illustrate the present invention.There is no detailed for preferred embodiment
All details are described, are not limited the invention to the specific embodiments described.Obviously, according to the content of this specification,
It can make many modifications and variations.This specification is chosen and specifically describes these embodiments, is in order to preferably explain the present invention
Principle and practical application so that skilled artisan can be best understood by and utilize the present invention.The present invention is only
It is limited by claims and its four corner and equivalent.
Claims (6)
1. a kind of suture of continuous and effective bactericidal, which is characterized in that configured by the raw material of following parts by weight：
Modification of chitosan 80-100 parts by weight, polyvinylpyrrolidone 1-3 parts by weight, polyglycolic acid 1-2 parts by weight, syringic acid 0.05-
0.1 parts by weight, sodium alginate 0.1-0.5 parts by weight, glucose 0.5-2 parts by weight, Seabuckthorn Oil 1.5-3 parts by weight；
Wherein, the preparation method of modification of chitosan is：Sorbierite is taken to be dissolved into anhydrous ether solution, thionyl chloride is added in and obtains
Solution A adds in the acetic acid solution of chitosan after reaction, rear after reaction to stand, and adds in excessive precipitating reagent, precipitates product, purifies
It is dry, obtain modification of chitosan.
A kind of 2. suture of continuous and effective bactericidal according to claim 1, which is characterized in that the modification
The preparation method of chitosan is：Sorbierite is added in anhydrous ether solution and is dissolved, thionyl chloride is gradually added into, obtains solution A,
After sulfoxide to be chlorinated is completely dissolved, with ultrasonication 10-15min, reflux is cooled to 0-15 degrees Celsius, slow shell adding glycan
Acetic acid solution, keep mixed solution temperature in the range of 0-15 degrees Celsius ultrasound 60-80min, at 0-15 degrees Celsius
At a temperature of stand 20-24h, add in excessive precipitating reagent, suction filtration obtains sediment, is taken out after impregnating sediment 20-24h with soak
Filter obtains filter cake, filter cake is dissolved into acetone, soxhlet extraction 20-24h, vacuum drying obtains modification of chitosan.
3. according to a kind of suture of continuous and effective bactericidal of claim 1-2 any one of them, which is characterized in that
In the preparation method of modification of chitosan, precipitating reagent is acetone.
A kind of 4. suture of continuous and effective bactericidal according to claim 2, which is characterized in that the immersion
Liquid is absolute ethyl alcohol and the mixture of anhydrous ether, and the wherein volume ratio of absolute ethyl alcohol and anhydrous ether is 7:3.
5. according to a kind of suture of continuous and effective bactericidal of claim 1-2 any one of them, which is characterized in that
Sorbierite, thionyl chloride, the w/v of anhydrous ether are 3 in the solution A:5:50~70.
6. according to a kind of suture of continuous and effective bactericidal of claim 1-2 any one of them, which is characterized in that
In the acetic acid solution of the chitosan, the w/v of chitosan and acetic acid is 1~1.5:50.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711436336.2A CN108096627A (en) | 2017-12-26 | 2017-12-26 | A kind of suture of continuous and effective bactericidal |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711436336.2A CN108096627A (en) | 2017-12-26 | 2017-12-26 | A kind of suture of continuous and effective bactericidal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108096627A true CN108096627A (en) | 2018-06-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711436336.2A Withdrawn CN108096627A (en) | 2017-12-26 | 2017-12-26 | A kind of suture of continuous and effective bactericidal |
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| CN (1) | CN108096627A (en) |
Citations (8)
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|---|---|---|---|---|
| JP2007216041A (en) * | 2006-01-16 | 2007-08-30 | Ito:Kk | Polymer composition for healing wound |
| CN101255202A (en) * | 2007-12-12 | 2008-09-03 | 中国海洋大学 | p-benzoyl amido benzoyl chitosan and preparation thereof |
| CN102617878A (en) * | 2012-04-11 | 2012-08-01 | 武汉大学 | Preparation method of chitosan-based antibacterial membrane material |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105107016A (en) * | 2015-08-11 | 2015-12-02 | 安徽省康宁医疗用品有限公司 | Absorbable medical suture line with excellent antibacterial property |
| CN105251042A (en) * | 2015-10-28 | 2016-01-20 | 钊桂英 | Medical absorbable polyglycolic acid (PGA) operation suture line and preparing method |
| CN105999376A (en) * | 2016-06-15 | 2016-10-12 | 湖州科达化工燃料有限公司 | Surgical suture with effects of easing pain and resisting bacteria |
| CN105999379A (en) * | 2016-06-16 | 2016-10-12 | 湖州科达化工燃料有限公司 | Antisepsis and anti-inflammation medical absorbable suture line |
-
2017
- 2017-12-26 CN CN201711436336.2A patent/CN108096627A/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007216041A (en) * | 2006-01-16 | 2007-08-30 | Ito:Kk | Polymer composition for healing wound |
| CN101255202A (en) * | 2007-12-12 | 2008-09-03 | 中国海洋大学 | p-benzoyl amido benzoyl chitosan and preparation thereof |
| CN102617878A (en) * | 2012-04-11 | 2012-08-01 | 武汉大学 | Preparation method of chitosan-based antibacterial membrane material |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105107016A (en) * | 2015-08-11 | 2015-12-02 | 安徽省康宁医疗用品有限公司 | Absorbable medical suture line with excellent antibacterial property |
| CN105251042A (en) * | 2015-10-28 | 2016-01-20 | 钊桂英 | Medical absorbable polyglycolic acid (PGA) operation suture line and preparing method |
| CN105999376A (en) * | 2016-06-15 | 2016-10-12 | 湖州科达化工燃料有限公司 | Surgical suture with effects of easing pain and resisting bacteria |
| CN105999379A (en) * | 2016-06-16 | 2016-10-12 | 湖州科达化工燃料有限公司 | Antisepsis and anti-inflammation medical absorbable suture line |
Non-Patent Citations (1)
| Title |
|---|
| 金晓晓: "新型壳聚糖衍生物的制备及其抗菌活性研究", 《中国优秀硕士学位论文全文数据库工程科技Ⅰ辑》 * |
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Application publication date: 20180601 |