CN105999376A - Surgical suture with effects of easing pain and resisting bacteria - Google Patents
Surgical suture with effects of easing pain and resisting bacteria Download PDFInfo
- Publication number
- CN105999376A CN105999376A CN201610427060.0A CN201610427060A CN105999376A CN 105999376 A CN105999376 A CN 105999376A CN 201610427060 A CN201610427060 A CN 201610427060A CN 105999376 A CN105999376 A CN 105999376A
- Authority
- CN
- China
- Prior art keywords
- parts
- effects
- suture thread
- surgical suture
- antibiotic effect
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a surgical suture with the effects of easing pain and resisting bacteria. The surgical suture is prepared from, by weight, 65-75 parts of polypropylene, 5-15 parts of glycerol, 3-8 parts of fimbrin, 3-7 parts of neutral lipase, 10-14 parts of chitosan, 4-9 parts of ethyl acetate, 2-9 parts of polyvinylpyrrolidone, 11-14 parts of radix sanguisorbae powder, 3-5 parts of zinc oxide, 5-10 parts of sodium carboxymethylcellulose, 15-25 parts of pectin, 11-14 parts of sodium alginate and 11-15 parts of polymethylene carbonic ester. The surgical suture with the effects of easing pain and resisting bacteria has the good effects of easing pain and resisting bacteria and is good in blood compatibility and histocompatibility, free of inflammatory responses, free of rejection responses and adverse effects in a human body, convenient to use, wide in raw material source, low in cost and capable of not increasing the economical burden of a patient.
Description
Technical field
The invention belongs to biomedical materials field, be specifically related to one and there is analgesia antibiotic effect
Operation suture thread.
Background technology
Biomaterial is for tissue and the diagnosis of organ, repairs or promote the one of its function
Class High-tech Material, is i.e. used for replacing, repairing living tissue natural or artificial material, its effect
Medicine is irreplaceable.Biomaterial can perform, promote or replace because disease, damage etc. lose
Certain function, and rejected region can not be recovered.Since the later stage nineties, world's biology material
Material Science and Technology develops rapidly, even if under the overall situation that current global economy is low, biological
Material still remains annual 13% rapid growth, has fully demonstrated its powerful vitality with wide
Wealthy development prospect.The regeneration of modern medicine forward and rebuild impaired tissue and organ,
Recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment to develop.Traditional nothing
The conventional materials such as the medical metal of life, macromolecule, bioceramic can not meet medical development
Requirement, biomedical material scientific and engineering is faced with new opportunities and challenges.Future, raw
Medicine may well will be caught up with in the market share of thing medical material.Therefore, bio-medical is strengthened
The clinical application research of material and popularization and application, give priority to grinding of China's bio-medical material
Study carefully, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice,
Country currently has been achieved for important breakthrough progress in terms of biomaterial scientific basic research, walks
In world's rank of advanced units, but industrialization level waits to improve, and industry size is little, development is relative
Delayed, it is not met by being actually needed of Medicare health care.In national policy, economic big
Under power is supported, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen autonomous innovation
Ability, solve further to rely on the situation of import, add large outlet dynamics, it is achieved cross over simultaneously
Development, expands Chinese biological material product power of influence in the world.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial bag
Include metal material (such as alkali metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyl
Base apatite etc.) and organic material three major types.Organic material is mainly polymeric set compound material
Material, macromolecular material generally by material properties be divided into synthesis macromolecular material (polyurethane, polyester,
Polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber
Deng), natural macromolecular material (such as collagen, fibroin, cellulose, chitosan etc.)；According to
The purposes of material, these materials can be divided into again biologically inert (bioinert), biological activity
Or biodegradation (biodegradable) material, high molecular polymer (bioactive)
In, can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again life
Thing absorbability and biological nonabsorable.According to after material and contacting blood to blood constituent,
The state that affects of performance is then divided into blood compatible polymer and blood incompatibility.According to material
To the affinity of body cell with report situations, biocompatibility and bio-incompatibility can be divided into
Polymer etc..Wherein, operation suture thread just belongs to the one in biodegradation material, refers to
In the middle of surgical operation, for wound ligation Suture hemostasis and the special use of one of tissue apposition
Line.Two classes can be divided into: nonabsorable line and absorbable thread according to its biodegradability.The former
Have that tension intensity is high, be prone to sterilization, feature that tissue reaction is low, but the most not
Degraded, so needing after Feng Heing to take out stitches, easily brings secondary pain and infection and scar；
The latter can be degraded into soluble product in vivo, is absorbed by the body and progressively excretes body
Outward, thus to alleviate patient painful.In clinical practice, the most absorbable suture material should meet
Following condition: versatility, aseptic, electroless property, without surface tension, without anaphylaxis and nothing
Carcinogenecity, it is easy to operation, be unfavorable for bacterial growth, can ensure that during knotting line knot safety and without mill
Damage or cutting, can resist in-house contraction, stitching purpose can be absorbed by tissue after reaching and
Reaction is slight.But the absorbable suture that medical circle is commonly used mostly is catgut, polymer chemistry
, there is poor biocompatibility in synthetic thread, easily causes tissue immunity reaction, absorb not during use
Fully and the problem such as bad mechanical property.Current this preferable absorbable operation suture thread is the most not
Exist.And for the nonabsorable line of operation, effect is the most single, accordingly, it would be desirable to further
Improve, develop a kind of operation suture thread with analgesia antibiotic effect.
Summary of the invention
It is an object of the invention to provide a kind of operation suture thread with analgesia antibiotic effect.
To achieve these goals, the invention provides a kind of operation with analgesia antibiotic effect
Stitching thread, the following component including in parts by weight: polypropylene 65-75 part, bright glycerol
5-15 part, fimbrin 3-8 part, neutral lipase 3-7 part, chitosan 10-14 part,
Ethyl acetate 4-9 part, polyvinylpyrrolidone 2-9 part, Radix Sangusorbae powder 11-14 part, oxidation
Zinc 3-5 part, sodium carboxymethyl cellulose 5-10 part, pectin 15-25 part, sodium alginate 11-14
Part, polymethylene carbonic ester 11-15 part.
It also comprises Radix Angelicae Sinensis powder 10-15 part.
It also comprises succinic acid 5-11 part.
It also comprises tricalcium phosphate 3-8 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in reactor, in
Under room temperature after ultrasonic 1-6h, it is then heated to 50-90 DEG C, stirs 1-3h, obtain blend；
Blend is extruded, water-cooled, air-dry, pelletizing, obtain master batch；By master batch heating and melting, take off
Bubble and spray webbing, form primary filament, then by primary filament water-bath succeeding stretch, must have town
The operation suture thread of antibiotic effect bitterly.
Beneficial effect: a kind of operation suture thread with analgesia antibiotic effect of the present invention, has
Good analgesia antibiotic effect, blood compatibility and histocompatibility are good, and NIP reacts,
Without rejection and untoward reaction in human body, easy to use, raw material sources are extensive, cheap,
Do not increase patient economy burden.
Detailed description of the invention
Embodiment 1
The operation suture thread with analgesia antibiotic effect of the present embodiment, including according to parts by weight
The following component of meter: polypropylene 65 parts, bright glycerol 5 parts, fimbrin 3 parts, neutral fat
Fat enzyme 3 parts, chitosan 10 parts, ethyl acetate 4 parts, polyvinylpyrrolidone 2 parts,
Elm powder 11 parts, zinc oxide 3 parts, sodium carboxymethyl cellulose 5 parts, pectin 15 parts, alginic acid
11 parts of sodium, polymethylene carbonic ester 11 parts.
Embodiment 2
The operation suture thread with analgesia antibiotic effect of the present embodiment, including according to parts by weight
The following component of meter: polypropylene 75 parts, bright glycerol 15 parts, fimbrin 8 parts, neutral fat
Fat enzyme 7 parts, chitosan 14 parts, ethyl acetate 9 parts, polyvinylpyrrolidone 9 parts,
Elm powder 14 parts, zinc oxide 5 parts, sodium carboxymethyl cellulose 10 parts, pectin 25 parts, Sargassum
Acid 14 parts of sodium, polymethylene carbonic ester 15 parts, Radix Angelicae Sinensis powder 15 parts.
Embodiment 3
The operation suture thread with analgesia antibiotic effect of the present embodiment, including according to parts by weight
The following component of meter: polypropylene 65 parts, bright glycerol 5 parts, fimbrin 3 parts, neutral fat
Fat enzyme 3 parts, chitosan 10 parts, ethyl acetate 4 parts, polyvinylpyrrolidone 2 parts,
Elm powder 11 parts, zinc oxide 3 parts, sodium carboxymethyl cellulose 5 parts, pectin 15 parts, alginic acid
11 parts of sodium, polymethylene carbonic ester 11 parts, Radix Angelicae Sinensis powder 10 parts, succinic acid 5 parts.
Embodiment 4
The operation suture thread with analgesia antibiotic effect of the present embodiment, including according to parts by weight
The following component of meter: polypropylene 75 parts, bright glycerol 15 parts, fimbrin 8 parts, neutral fat
Fat enzyme 7 parts, chitosan 14 parts, ethyl acetate 9 parts, polyvinylpyrrolidone 9 parts,
Elm powder 14 parts, zinc oxide 5 parts, sodium carboxymethyl cellulose 10 parts, pectin 25 parts, Sargassum
Acid 14 parts of sodium, polymethylene carbonic ester 15 parts, Radix Angelicae Sinensis powder 15 parts, succinic acid 11 parts, phosphorus
Acid DFP 8 parts.
The above, be only presently preferred embodiments of the present invention, not makees the present invention any
Pro forma restriction, although the present invention is disclosed above with preferred embodiment, but and is not used to
Limiting the present invention, any those skilled in the art, without departing from technical solution of the present invention
In the range of, when the technology contents of available the disclosure above makes a little change or is modified to equivalent change
The Equivalent embodiments changed, as long as being the content without departing from technical solution of the present invention, according to the present invention
Technical spirit any simple modification, equivalent variations and modification that above example is made, all
Still fall within the range of technical solution of the present invention.
Claims (4)
1. one kind have analgesia antibiotic effect operation suture thread, it is characterised in that include according to
The following component of parts by weight meter: polypropylene 65-75 part, bright glycerol 5-15 part, tow egg
White 3-8 part, neutral lipase 3-7 part, chitosan 10-14 part, ethyl acetate 4-9 part,
Polyvinylpyrrolidone 2-9 part, Radix Sangusorbae powder 11-14 part, zinc oxide 3-5 part, carboxymethyl
Sodium cellulosate 5-10 part, pectin 15-25 part, sodium alginate 11-14 part, polymethylene carbon
Acid esters 11-15 part.
The operation suture thread with analgesia antibiotic effect the most according to claim 1, its
It is characterised by: it also comprises Radix Angelicae Sinensis powder 10-15 part.
The operation suture thread with analgesia antibiotic effect the most according to claim 2, its
It is characterised by: it also comprises succinic acid 5-11 part.
The operation suture thread with analgesia antibiotic effect the most according to claim 3, its
It is characterised by: it also comprises tricalcium phosphate 3-8 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610427060.0A CN105999376A (en) | 2016-06-15 | 2016-06-15 | Surgical suture with effects of easing pain and resisting bacteria |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610427060.0A CN105999376A (en) | 2016-06-15 | 2016-06-15 | Surgical suture with effects of easing pain and resisting bacteria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105999376A true CN105999376A (en) | 2016-10-12 |
Family
ID=57088551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610427060.0A Withdrawn CN105999376A (en) | 2016-06-15 | 2016-06-15 | Surgical suture with effects of easing pain and resisting bacteria |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105999376A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106540309A (en) * | 2016-11-25 | 2017-03-29 | 江苏爱西施科技服务咨询股份有限公司 | A kind of fibroin albumen stitching thread with promotion wound healing effect and preparation method thereof |
| CN108096627A (en) * | 2017-12-26 | 2018-06-01 | 庞庆华 | A kind of suture of continuous and effective bactericidal |
| CN111558080A (en) * | 2020-06-15 | 2020-08-21 | 南昌大学 | Antibacterial silk suture line with double-light response function and preparation method thereof |
| CN114057898A (en) * | 2021-11-19 | 2022-02-18 | 沭阳富宴生物科技有限公司 | Modified cellulose and preparation method and application thereof |
| WO2022087425A1 (en) * | 2020-10-23 | 2022-04-28 | Lanny Leo Johnson | Wound closure devices comprising protocatechuic acid |
-
2016
- 2016-06-15 CN CN201610427060.0A patent/CN105999376A/en not_active Withdrawn
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106540309A (en) * | 2016-11-25 | 2017-03-29 | 江苏爱西施科技服务咨询股份有限公司 | A kind of fibroin albumen stitching thread with promotion wound healing effect and preparation method thereof |
| CN108096627A (en) * | 2017-12-26 | 2018-06-01 | 庞庆华 | A kind of suture of continuous and effective bactericidal |
| CN111558080A (en) * | 2020-06-15 | 2020-08-21 | 南昌大学 | Antibacterial silk suture line with double-light response function and preparation method thereof |
| WO2022087425A1 (en) * | 2020-10-23 | 2022-04-28 | Lanny Leo Johnson | Wound closure devices comprising protocatechuic acid |
| CN114057898A (en) * | 2021-11-19 | 2022-02-18 | 沭阳富宴生物科技有限公司 | Modified cellulose and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105999376A (en) | Surgical suture with effects of easing pain and resisting bacteria | |
| Namvar et al. | Potential use of plant fibres and their composites for biomedical applications | |
| CN106075545A (en) | A kind of soft tissue binding agent with antibacterial anti hemorrhagic effect | |
| CN104448479A (en) | Medical antibacterial agent modified LDPE and preparation method thereof | |
| CN105999375A (en) | Medical absorbable suture with effects of easing pain and resisting bacteria | |
| CN105963759A (en) | Medical membrane for promoting wound healing | |
| Nath et al. | Recent advances in production of sustainable and biodegradable polymers from agro-food waste: Applications in tissue engineering and regenerative medicines | |
| CN106075541A (en) | A kind of operation suture thread promoting wound healing | |
| CN106039386A (en) | Anti-infection surgical suture | |
| CN105999379A (en) | Antisepsis and anti-inflammation medical absorbable suture line | |
| CN106366589B (en) | Degradable composite material and application its intrauterine device and preparation method thereof | |
| CN105963802A (en) | Anti-adhesion membrane for promoting wound healing | |
| CN102618954B (en) | Human serum albumin nano biomaterial and preparation method thereof | |
| CN105999378A (en) | Operation absorbable suture line | |
| CN105999380A (en) | Anti-infective medical absorbable suture line | |
| CN105944136A (en) | Medical absorbable suture capable of promoting wound healing | |
| CN106039387A (en) | Medical absorbable suture | |
| CN106039385A (en) | Operation suture line having antibacterial effect | |
| CN105999389A (en) | Skin adhesive with effects of resisting bacteria and stopping bleeding | |
| CN106075531A (en) | A kind of medical film of reducing swelling and alleviating pain | |
| CN106075542A (en) | A kind of operation suture thread of anti-inflammation | |
| CN109224117A (en) | A kind of production method of the bacteria cellulose operation suture thread of antibacterial | |
| CN106075611A (en) | A kind of Antiadhesive film with antiphlogistic antibacterial effect | |
| CN105999388A (en) | Soft tissue adhesive with effects of relieving swelling and pain | |
| CN105999377A (en) | Medical absorbable suture line with antibacterial effect |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161012 |
|
| WW01 | Invention patent application withdrawn after publication |