CN105999389A - Skin adhesive with effects of resisting bacteria and stopping bleeding - Google Patents
Skin adhesive with effects of resisting bacteria and stopping bleeding Download PDFInfo
- Publication number
- CN105999389A CN105999389A CN201610428315.5A CN201610428315A CN105999389A CN 105999389 A CN105999389 A CN 105999389A CN 201610428315 A CN201610428315 A CN 201610428315A CN 105999389 A CN105999389 A CN 105999389A
- Authority
- CN
- China
- Prior art keywords
- parts
- binding agent
- effects
- stopping bleeding
- antibacterial anti
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention discloses a skin adhesive with the effects of resisting bacteria and stopping bleeding. The skin adhesive is prepared from, by weight, 60-75 parts of polyorthoester, 3-10 parts of lemon peel pectin, 5-8 parts of hydroxypropyl methacrylate, 3-9 parts of mannose, 2-6 parts of divinyl sulfone, 4-12 parts of polysorbate, 3-8 parts of tricalcium phosphate, 5-10 parts of tea polyphenol, 3-5 parts of zinc oxide, 6-10 parts of calendula oil and 5-10 parts of sodium carboxymethylcellulose. The skin adhesive with the effects of resisting bacteria and stopping bleeding is low in irritation, high in adhesive strength, good in adhesive film toughness and free of side effects, has the effects of resisting bacteria and stopping bleeding and can be widely applied to clinical treatment.
Description
Technical field
The invention belongs to biomedical materials field, be specifically related to one and there is antibacterial anti hemorrhagic effect
Skin binding agent.
Background technology
Biomaterial is for tissue and the diagnosis of organ, repairs or promote the one of its function
Class High-tech Material, is i.e. used for replacing, repairing living tissue natural or artificial material, its effect
Medicine is irreplaceable.Biomaterial can perform, promote or replace because disease, damage etc. lose
Certain function, and rejected region can not be recovered.Since the later stage nineties, world's biology material
Material Science and Technology develops rapidly, even if under the overall situation that current global economy is low, biological
Material still remains annual 13% rapid growth, has fully demonstrated its powerful vitality with wide
Wealthy development prospect.The regeneration of modern medicine forward and rebuild impaired tissue and organ,
Recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment to develop.Traditional nothing
The conventional materials such as the medical metal of life, macromolecule, bioceramic can not meet medical development
Requirement, biomedical material scientific and engineering is faced with new opportunities and challenges.Future, raw
Medicine may well will be caught up with in the market share of thing medical material.Therefore, bio-medical is strengthened
The clinical application research of material and popularization and application, give priority to grinding of China's bio-medical material
Study carefully, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice,
Country currently has been achieved for important breakthrough progress in terms of biomaterial scientific basic research, walks
In world's rank of advanced units, but industrialization level waits to improve, and industry size is little, development is relative
Delayed, it is not met by being actually needed of Medicare health care.In national policy, economic big
Under power is supported, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen autonomous innovation
Ability, solve further to rely on the situation of import, add large outlet dynamics, it is achieved cross over simultaneously
Development, expands Chinese biological material product power of influence in the world.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial bag
Include metal material (such as alkali metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyl
Base apatite etc.) and organic material three major types.Organic material is mainly polymeric set compound material
Material, macromolecular material generally by material properties be divided into synthesis macromolecular material (polyurethane, polyester,
Polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber
Deng), natural macromolecular material (such as collagen, fibroin, cellulose, chitosan etc.)；According to
The purposes of material, these materials can be divided into again biologically inert (bioinert), biological activity
Or biodegradation (biodegradable) material, high molecular polymer (bioactive)
In, can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again life
Thing absorbability and biological nonabsorable.According to after material and contacting blood to blood constituent,
The state that affects of performance is then divided into blood compatible polymer and blood incompatibility.According to material
To the affinity of body cell with report situations, biocompatibility and bio-incompatibility can be divided into
Polymer etc..
Adhesive of medical just belongs to the one in biodegradation material, and adhesive of medical is mainly used in
The various operations of surgery such as various traumatic wounds, cosmetic surgery, family planning, it is to human-body biological
Tissue has quick-binding, promotes the effects such as wound healing, can partly replace wound suture.Doctor
With a long history with the use of binding agent, clinic has highly important effect, soft group can be divided into
Knit with binding agent, dental binding agent, bone cement and skin binding agent etc..Wherein, skin
It is a kind of medical adhesive with binding agent, for binding skin wound.Along with the progress of medical science, clinical
On to surgical technic and auxiliary material result requirement more and more higher.The theory of modern medicine is intended to
Reduce the misery of patient to greatest extent, allow patients ' recovery prestissimo, and in maximum journey
While degree ground recovers function, it is desirable to outward appearance also can ideally be recovered.Therefore clinical demand is not
Disconnected increase has promoted development and adhering technique that adhesive of medical studies in clinical application.Simultaneously
The skin binding agent that medical circle is conventional at present, comes with some shortcomings, as relatively low in viscosity, bonding
Insufficient strength, function singleness etc..Accordingly, it would be desirable to develop a kind of bonding strength height and have anti-
The skin binding agent of bacterium hemostasia effect.
Summary of the invention
It is an object of the invention to provide a kind of skin binding agent with antibacterial anti hemorrhagic effect.
To achieve these goals, the invention provides a kind of skin with antibacterial anti hemorrhagic effect
With binding agent, comprise following parts by weight of component: poe 60-75 part, pectin from lemon peel
3-10 part, Hydroxypropyl methacrylate 5-8 part, mannose 3-9 part, divinylsulfone 2-6
Part, polysorbate 4-12 part, tricalcium phosphate 3-8 part, tea polyphenols 5-10 part, zinc oxide
3-5 part, Flos Inulae oil 6-10 part, sodium carboxymethyl cellulose 5-10 part.
It also comprises linoleic acid 5-9 part.
It also comprises Tripolyglycerol monostearates 3-5 part.
It also comprises Fibrin Glue 10-15 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, in room
Under temperature after ultrasonic 1-6h, it is then heated to 40-100 DEG C, stirs 1-3h, then the place that carries out disinfection
Manage.
Beneficial effect: a kind of skin binding agent with antibacterial anti hemorrhagic effect of the present invention stimulates
Property low, adhesion strength is high, adhesive film good toughness, has no side effect, also has the merit of antibacterial anti hemorrhagic
Effect, can be widely used in clinical treatment.
Detailed description of the invention
Embodiment 1
The skin binding agent with antibacterial anti hemorrhagic effect of the present embodiment, comprises following weight portion
Component: poe 60 parts, pectin from lemon peel 3 parts, Hydroxypropyl methacrylate 5 parts,
Mannose 3 parts, divinylsulfone 2 parts, polysorbate 4 parts, tricalcium phosphate 3 parts, tea
Polyphenol 5 parts, zinc oxide 3 parts, Flos Inulae oil 6 parts, sodium carboxymethyl cellulose 5 parts.
Embodiment 2
The skin binding agent with antibacterial anti hemorrhagic effect of the present embodiment, comprises following weight portion
Component: poe 75 parts, pectin from lemon peel 10 parts, Hydroxypropyl methacrylate 8 parts,
Mannose 9 parts, divinylsulfone 6 parts, polysorbate 12 parts, tricalcium phosphate 8 parts,
Tea polyphenols 10 parts, zinc oxide 5 parts, Flos Inulae oil 10 parts, sodium carboxymethyl cellulose 10 parts,
Linoleic acid 9 parts.
Embodiment 3
The skin binding agent with antibacterial anti hemorrhagic effect of the present embodiment, comprises following weight portion
Component: poe 60 parts, pectin from lemon peel 3 parts, Hydroxypropyl methacrylate 5 parts,
Mannose 3 parts, divinylsulfone 2 parts, polysorbate 4 parts, tricalcium phosphate 3 parts, tea
Polyphenol 5 parts, zinc oxide 3 parts, Flos Inulae oil 6 parts, sodium carboxymethyl cellulose 5 parts, sub-oil
Acid 5 parts, Tripolyglycerol monostearates 3 parts.
Embodiment 4
The skin binding agent with antibacterial anti hemorrhagic effect of the present embodiment, comprises following weight portion
Component: poe 75 parts, pectin from lemon peel 10 parts, Hydroxypropyl methacrylate 8 parts,
Mannose 9 parts, divinylsulfone 6 parts, polysorbate 12 parts, tricalcium phosphate 8 parts,
Tea polyphenols 10 parts, zinc oxide 5 parts, Flos Inulae oil 10 parts, sodium carboxymethyl cellulose 10 parts,
Linoleic acid 9 parts, Tripolyglycerol monostearates 5 parts, Fibrin Glue 15 parts.
The above, be only presently preferred embodiments of the present invention, not makees the present invention any
Pro forma restriction, although the present invention is disclosed above with preferred embodiment, but and is not used to
Limiting the present invention, any those skilled in the art, without departing from technical solution of the present invention
In the range of, when the technology contents of available the disclosure above makes a little change or is modified to equivalent change
The Equivalent embodiments changed, as long as being the content without departing from technical solution of the present invention, according to the present invention
Technical spirit any simple modification, equivalent variations and modification that above example is made, all
Still fall within the range of technical solution of the present invention.
Claims (4)
1. a skin binding agent with antibacterial anti hemorrhagic effect, it is characterised in that comprise with
Lower parts by weight of component: poe 60-75 part, pectin from lemon peel 3-10 part, metering system
Acid hydroxypropyl acrylate 5-8 part, mannose 3-9 part, divinylsulfone 2-6 part, polysorbate
4-12 part, tricalcium phosphate 3-8 part, tea polyphenols 5-10 part, zinc oxide 3-5 part, Flos Inulae
Oil 6-10 part, sodium carboxymethyl cellulose 5-10 part.
The skin binding agent with antibacterial anti hemorrhagic effect the most according to claim 1,
It is characterized in that: it also comprises linoleic acid 5-9 part.
The skin binding agent with antibacterial anti hemorrhagic effect the most according to claim 2,
It is characterized in that: it also comprises Tripolyglycerol monostearates 3-5 part.
The skin binding agent with antibacterial anti hemorrhagic effect the most according to claim 3,
It is characterized in that: it also comprises Fibrin Glue 10-15 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610428315.5A CN105999389A (en) | 2016-06-15 | 2016-06-15 | Skin adhesive with effects of resisting bacteria and stopping bleeding |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610428315.5A CN105999389A (en) | 2016-06-15 | 2016-06-15 | Skin adhesive with effects of resisting bacteria and stopping bleeding |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105999389A true CN105999389A (en) | 2016-10-12 |
Family
ID=57087870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610428315.5A Withdrawn CN105999389A (en) | 2016-06-15 | 2016-06-15 | Skin adhesive with effects of resisting bacteria and stopping bleeding |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105999389A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107714833A (en) * | 2017-10-24 | 2018-02-23 | 中山昱普生物科技开发有限公司 | Itch-relieving and sterilizing water |
-
2016
- 2016-06-15 CN CN201610428315.5A patent/CN105999389A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107714833A (en) * | 2017-10-24 | 2018-02-23 | 中山昱普生物科技开发有限公司 | Itch-relieving and sterilizing water |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161012 |
|
| WW01 | Invention patent application withdrawn after publication |