CN105944137A - Skin bonding agent with effect of promoting wound healing - Google Patents
Skin bonding agent with effect of promoting wound healing Download PDFInfo
- Publication number
- CN105944137A CN105944137A CN201610398158.8A CN201610398158A CN105944137A CN 105944137 A CN105944137 A CN 105944137A CN 201610398158 A CN201610398158 A CN 201610398158A CN 105944137 A CN105944137 A CN 105944137A
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- Prior art keywords
- parts
- wound healing
- skin
- promoting wound
- effect
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Medicinal Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a skin bonding agent with the effect of promoting wound healing. The skin bonding agent is prepared from, by weight, 60-70 parts of polylysine, 11-14 parts of gum tragacanth, 11-15 parts of cellulose, 5-8 parts of hydroxypropyl methacrylate, 5-10 parts of lauryl sodium sulfate, 12-20 parts of chitosan lactate, 6-10 parts of calendula officinalis flower oil, 10-15 parts of fibrin glue, 8-15 parts of rhizoma cimicifugae powder, 11-14 parts of radix sanguisorbae powder, 5-10 parts of sodium carboxymethylcellulose and 3-7 parts of azone. The skin bonding agent with the effect of promoting wound healing has the advantages of being high in bonding strength, high in bonding speed and free of side effects, can assist in healing of wounds in the surface skin of an organism, is small in irritation and meets the requirements of clinical medical bonding agents.
Description
Technical field
The invention belongs to biomedical materials field, be specifically related to one and there is promotion wound healing
The skin binding agent of effect.
Background technology
Biomaterial is for tissue and the diagnosis of organ, repairs or promote the one of its function
Class High-tech Material, is i.e. used for replacing, repairing living tissue natural or artificial material, its effect
Medicine is irreplaceable.Biomaterial can perform, promote or replace because disease, damage etc. lose
Certain function, and rejected region can not be recovered.Since the later stage nineties, world's biology material
Material Science and Technology develops rapidly, even if under the overall situation that current global economy is low, biological
Material still remains annual 13% rapid growth, has fully demonstrated its powerful vitality with wide
Wealthy development prospect.The regeneration of modern medicine forward and rebuild impaired tissue and organ,
Recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment to develop.Traditional nothing
The conventional materials such as the medical metal of life, macromolecule, bioceramic can not meet medical development
Requirement, biomedical material scientific and engineering is faced with new opportunities and challenges.Future, raw
Medicine may well will be caught up with in the market share of thing medical material.Therefore, bio-medical is strengthened
The clinical application research of material and popularization and application, give priority to grinding of China's bio-medical material
Study carefully, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice,
Country currently has been achieved for important breakthrough progress in terms of biomaterial scientific basic research, walks
In world's rank of advanced units, but industrialization level waits to improve, and industry size is little, development is relative
Delayed, it is not met by being actually needed of Medicare health care.In national policy, economic big
Under power is supported, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen autonomous innovation
Ability, solve further to rely on the situation of import, add large outlet dynamics, it is achieved cross over simultaneously
Development, expands Chinese biological material product power of influence in the world.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial bag
Include metal material (such as alkali metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyl
Base apatite etc.) and organic material three major types.Organic material is mainly polymeric set compound material
Material, macromolecular material generally by material properties be divided into synthesis macromolecular material (polyurethane, polyester,
Polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber
Deng), natural macromolecular material (such as collagen, fibroin, cellulose, chitosan etc.)；According to
The purposes of material, these materials can be divided into again biologically inert (bioinert), biological activity
Or biodegradation (biodegradable) material, high molecular polymer (bioactive)
In, can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again life
Thing absorbability and biological nonabsorable.According to after material and contacting blood to blood constituent,
The state that affects of performance is then divided into blood compatible polymer and blood incompatibility.According to material
To the affinity of body cell with report situations, biocompatibility and bio-incompatibility can be divided into
Polymer etc..
Adhesive of medical just belongs to the one in biodegradation material, and adhesive of medical is mainly used in
The various operations of surgery such as various traumatic wounds, cosmetic surgery, family planning, it is to human-body biological
Tissue has quick-binding, promotes the effects such as wound healing, can partly replace wound suture.Doctor
With a long history with the use of binding agent, clinic has highly important effect, soft group can be divided into
Knit with binding agent, dental binding agent, bone cement and skin binding agent etc..Wherein, skin
It is a kind of medical adhesive with binding agent, for binding skin wound.Along with the progress of medical science, clinical
On to surgical technic and auxiliary material result requirement more and more higher.The theory of modern medicine is intended to
Reduce the misery of patient to greatest extent, allow patients ' recovery prestissimo, and in maximum journey
While degree ground recovers function, it is desirable to outward appearance also can ideally be recovered.Therefore clinical demand is not
Disconnected increase has promoted development and adhering technique that adhesive of medical studies in clinical application.Simultaneously
The skin binding agent that medical circle is conventional at present, comes with some shortcomings, as relatively low in viscosity, bonding
Insufficient strength, function singleness etc..Accordingly, it would be desirable to develop a kind of bonding strength height and there is rush
Enter the skin binding agent of wound healing effect.
Summary of the invention
It is an object of the invention to provide a kind of skin with promotion wound healing effect and use viscous
Mixture.
To achieve these goals, the invention provides a kind of have promote wound healing effect
Skin binding agent, comprises following parts by weight of component: polylysine 60-70 part, tragacanth
11-14 part, cellulose 11-15 part, Hydroxypropyl methacrylate 5-8 part, dodecyl sulfur
Acid sodium 5-10 part, chitosan lactate 12-20 part, Flos Inulae oil 6-10 part, fibrin
Glue 10-15 part, Rhizoma Cimicifugae powder 8-15 part, Radix Sangusorbae powder 11-14 part, sodium carboxymethyl cellulose 5-10
Part, azone 3-7 part.
It also comprises sweet potato starch 15-20 part.
It also comprises linoleic acid 5-9 part.
It also comprises carbomer 3-5 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, in room
Under temperature after ultrasonic 1-6h, it is then heated to 40-100 DEG C, stirs 1-3h, then the place that carries out disinfection
Manage.
Beneficial effect: a kind of of the present invention has the skin binding agent promoting wound healing effect
Having adhesion strength high, bonding is quick, the feature having no side effect, and can assist organism surface simultaneously
The healing of surface skin wound tissue, stimulates little, reaches the requirement of clinical medical binding agent.
Detailed description of the invention
Embodiment 1
The skin binding agent with promotion wound healing effect of the present embodiment, comprises following heavy
Amount part component: polylysine 70 parts, tragacanth 14 parts, cellulose 15 parts, metering system
Acid hydroxypropyl acrylate 8 parts, sodium lauryl sulphate 10 parts, chitosan lactate 20 parts, Flos Inulae
Oil 10 parts, Fibrin Glue 15 parts, 15 parts of Rhizoma Cimicifugae powder, Radix Sangusorbae powder 14 parts, carboxymethyl are fine
Dimension element 10 parts of sodium, azone 7 parts.
Embodiment 2
The skin binding agent with promotion wound healing effect of the present embodiment, comprises following heavy
Amount part component: polylysine 60 parts, tragacanth 11 parts, cellulose 11 parts, metering system
Acid hydroxypropyl acrylate 5 parts, sodium lauryl sulphate 5 parts, chitosan lactate 12 parts, Flos Inulae
Oil 6 parts, Fibrin Glue 10 parts, 8 parts of Rhizoma Cimicifugae powder, Radix Sangusorbae powder 11 parts, carboxymethyl cellulose
Element 5 parts of sodium, azone 3 parts, sweet potato starch 15 parts.
Embodiment 3
The skin binding agent with promotion wound healing effect of the present embodiment, comprises following heavy
Amount part component: polylysine 70 parts, tragacanth 14 parts, cellulose 15 parts, metering system
Acid hydroxypropyl acrylate 8 parts, sodium lauryl sulphate 10 parts, chitosan lactate 20 parts, Flos Inulae
Oil 10 parts, Fibrin Glue 15 parts, 15 parts of Rhizoma Cimicifugae powder, Radix Sangusorbae powder 14 parts, carboxymethyl are fine
Dimension element 10 parts of sodium, azone 7 parts, sweet potato starch 20 parts, linoleic acid 9 parts.
Embodiment 4
The skin binding agent with promotion wound healing effect of the present embodiment, comprises following heavy
Amount part component: polylysine 60 parts, tragacanth 11 parts, cellulose 11 parts, metering system
Acid hydroxypropyl acrylate 5 parts, sodium lauryl sulphate 5 parts, chitosan lactate 12 parts, Flos Inulae
Oil 6 parts, Fibrin Glue 10 parts, 8 parts of Rhizoma Cimicifugae powder, Radix Sangusorbae powder 11 parts, carboxymethyl cellulose
Element 5 parts of sodium, azone 3 parts, sweet potato starch 15 parts, linoleic acid 5 parts, carbomer 3 parts.
The above, be only presently preferred embodiments of the present invention, not makees the present invention any
Pro forma restriction, although the present invention is disclosed above with preferred embodiment, but and is not used to
Limiting the present invention, any those skilled in the art, without departing from technical solution of the present invention
In the range of, when the technology contents of available the disclosure above makes a little change or is modified to equivalent change
The Equivalent embodiments changed, as long as being the content without departing from technical solution of the present invention, according to the present invention
Technical spirit any simple modification, equivalent variations and modification that above example is made, all
Still fall within the range of technical solution of the present invention.
Claims (4)
1. one kind has the skin binding agent promoting wound healing effect, it is characterised in that bag
Containing following parts by weight of component: polylysine 60-70 part, tragacanth 11-14 part, cellulose
11-15 part, Hydroxypropyl methacrylate 5-8 part, sodium lauryl sulphate 5-10 part, shell
Polysaccharide lactate 12-20 part, Flos Inulae oil 6-10 part, Fibrin Glue 10-15 part, liter
Fiber crops powder 8-15 part, Radix Sangusorbae powder 11-14 part, sodium carboxymethyl cellulose 5-10 part, azone 3-7
Part.
The most according to claim 1 have the skin bonding promoting wound healing effect
Agent, it is characterised in that: it also comprises sweet potato starch 15-20 part.
The most according to claim 2 have the skin bonding promoting wound healing effect
Agent, it is characterised in that: it also comprises linoleic acid 5-9 part.
The most according to claim 3 have the skin bonding promoting wound healing effect
Agent, it is characterised in that: it also comprises carbomer 3-5 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610398158.8A CN105944137A (en) | 2016-06-06 | 2016-06-06 | Skin bonding agent with effect of promoting wound healing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610398158.8A CN105944137A (en) | 2016-06-06 | 2016-06-06 | Skin bonding agent with effect of promoting wound healing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105944137A true CN105944137A (en) | 2016-09-21 |
Family
ID=56908799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610398158.8A Withdrawn CN105944137A (en) | 2016-06-06 | 2016-06-06 | Skin bonding agent with effect of promoting wound healing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105944137A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06304239A (en) * | 1993-04-27 | 1994-11-01 | Nichiban Co Ltd | Adhesive tape for skin therapy |
| CN101909667A (en) * | 2008-01-10 | 2010-12-08 | 爱乐康株式会社 | Pressure-sensitive adhesive agent for skin, pressure-sensitive adhesive sheet for skin and face plate of ostomy appliance |
| CN102895700A (en) * | 2012-09-04 | 2013-01-30 | 青岛保利康新材料有限公司 | Medical wound repair polymer biomaterial |
| CN103272263A (en) * | 2013-05-22 | 2013-09-04 | 无锡市华明化工有限公司 | Medical adhesive |
-
2016
- 2016-06-06 CN CN201610398158.8A patent/CN105944137A/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06304239A (en) * | 1993-04-27 | 1994-11-01 | Nichiban Co Ltd | Adhesive tape for skin therapy |
| CN101909667A (en) * | 2008-01-10 | 2010-12-08 | 爱乐康株式会社 | Pressure-sensitive adhesive agent for skin, pressure-sensitive adhesive sheet for skin and face plate of ostomy appliance |
| CN102895700A (en) * | 2012-09-04 | 2013-01-30 | 青岛保利康新材料有限公司 | Medical wound repair polymer biomaterial |
| CN103272263A (en) * | 2013-05-22 | 2013-09-04 | 无锡市华明化工有限公司 | Medical adhesive |
Non-Patent Citations (2)
| Title |
|---|
| 苑振亭 等主编: "《临证中药500味手册（配彩图）》", 29 February 2016, 金盾出版社 * |
| 赵克键 主编: "《现代药学名词手册》", 31 October 2004, 中国医药科技出版社 * |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160921 |
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| WW01 | Invention patent application withdrawn after publication |