CN105999388A - Soft tissue adhesive with effects of relieving swelling and pain - Google Patents
Soft tissue adhesive with effects of relieving swelling and pain Download PDFInfo
- Publication number
- CN105999388A CN105999388A CN201610427515.9A CN201610427515A CN105999388A CN 105999388 A CN105999388 A CN 105999388A CN 201610427515 A CN201610427515 A CN 201610427515A CN 105999388 A CN105999388 A CN 105999388A
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- China
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- parts
- soft tissue
- pain
- effects
- alleviating pain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
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- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a soft tissue adhesive with the effects of relieving swelling and pain. The soft tissue adhesive is prepared from, by weight, 55-65 parts of polyvinyl pyrrolidone, 3-8 parts of agar, 5-11 parts of mupirocin, 3-7 parts of neutral lipase, 5-10 parts of sweet potato starch, 3-8 parts of ethyl acetate, 3-5 parts of triglycerol stearate, 5-15 parts of cortex dictamni powder, 11-14 parts of radix sanguisorbae powder, 5-9 parts of tricalcium phosphate and 3-5 parts of zinc oxide. The soft tissue adhesive with the effects of relieving swelling and pain has the high bonding strength and compressive strength, has little irritation to organism tissue, contains no harmful reagent, has the effects of relieving swelling and pain, and is suitable for being used for an surgical operation and especially suitable for soft tissue adhesion.
Description
Technical field
The invention belongs to biomedical materials field, be specifically related to one and there is reducing swelling and alleviating pain effect
Soft tissue binding agent.
Background technology
Biomaterial is for tissue and the diagnosis of organ, repairs or promote the one of its function
Class High-tech Material, is i.e. used for replacing, repairing living tissue natural or artificial material, its effect
Medicine is irreplaceable.Biomaterial can perform, promote or replace because disease, damage etc. lose
Certain function, and rejected region can not be recovered.Since the later stage nineties, world's biology material
Material Science and Technology develops rapidly, even if under the overall situation that current global economy is low, biological
Material still remains annual 13% rapid growth, has fully demonstrated its powerful vitality with wide
Wealthy development prospect.The regeneration of modern medicine forward and rebuild impaired tissue and organ,
Recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment to develop.Traditional nothing
The conventional materials such as the medical metal of life, macromolecule, bioceramic can not meet medical development
Requirement, biomedical material scientific and engineering is faced with new opportunities and challenges.Future, raw
Medicine may well will be caught up with in the market share of thing medical material.Therefore, bio-medical is strengthened
The clinical application research of material and popularization and application, give priority to grinding of China's bio-medical material
Study carefully, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice,
Country currently has been achieved for important breakthrough progress in terms of biomaterial scientific basic research, walks
In world's rank of advanced units, but industrialization level waits to improve, and industry size is little, development is relative
Delayed, it is not met by being actually needed of Medicare health care.In national policy, economic big
Under power is supported, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen autonomous innovation
Ability, solve further to rely on the situation of import, add large outlet dynamics, it is achieved cross over simultaneously
Development, expands Chinese biological material product power of influence in the world.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial bag
Include metal material (such as alkali metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyl
Base apatite etc.) and organic material three major types.Organic material is mainly polymeric set compound material
Material, macromolecular material generally by material properties be divided into synthesis macromolecular material (polyurethane, polyester,
Polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber
Deng), natural macromolecular material (such as collagen, fibroin, cellulose, chitosan etc.)；According to
The purposes of material, these materials can be divided into again biologically inert (bioinert), biological activity
Or biodegradation (biodegradable) material, high molecular polymer (bioactive)
In, can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again life
Thing absorbability and biological nonabsorable.According to after material and contacting blood to blood constituent,
The state that affects of performance is then divided into blood compatible polymer and blood incompatibility.According to material
To the affinity of body cell with report situations, biocompatibility and bio-incompatibility can be divided into
Polymer etc..
Adhesive of medical just belongs to the one in biodegradation material, and adhesive of medical is mainly used in
The various operations of surgery such as various traumatic wounds, cosmetic surgery, family planning, it is to human-body biological
Tissue has quick-binding, promotes the effects such as wound healing, can partly replace wound suture.Doctor
With a long history with the use of binding agent, clinic has highly important effect, soft group can be divided into
Knit with binding agent, dental binding agent, bone cement and skin binding agent etc..Wherein, soft group
Knitting with binding agent with biological tissue for bonding object, human body overwhelming majority tissue, organ are in treatment
During can apply adhering technique replace part sew up, ligation operation, it is not necessary to anesthesia.Soft
Tissue adhesive's purpose is to promote the normal healing of tissue itself, but the bonding of existing soft tissue
Agent comes with some shortcomings, such as bonding strength deficiency, function singleness etc..Accordingly, it would be desirable to develop
A kind of high bonding strength also has the soft tissue binding agent of reducing swelling and alleviating pain effect.
Summary of the invention
It is an object of the invention to provide a kind of soft tissue bonding with reducing swelling and alleviating pain effect
Agent.
To achieve these goals, the invention provides a kind of soft group with reducing swelling and alleviating pain effect
Knit with binding agent, comprise following parts by weight of component: polyvinyl pyrrolidone 55-65 part, fine jade
Fat 3-8 part, mupirocin 5-11 part, neutral lipase 3-7 part, sweet potato starch 5-10 part,
Ethyl acetate 3-8 part, Tripolyglycerol monostearates 3-5 part, dittany corium farinosum 5-15 part,
Radix Sangusorbae powder 11-14 part, tricalcium phosphate 5-9 part, zinc oxide 3-5 part.
It also comprises sodium carboxymethyl cellulose 5-10 part.
It also comprises sodium alginate 15-20 part.
It also comprises cellulose 11-14 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, in room
Under temperature after ultrasonic 1-6h, it is then heated to 40-100 DEG C, stirs 1-3h, then the place that carries out disinfection
Manage.
Beneficial effect: a kind of soft tissue binding agent with reducing swelling and alleviating pain effect of the present invention has
There are higher adhesion strength and comprcssive strength, bio-tissue stimulated little, has without any
Evil reagent, also has effect of reducing swelling and alleviating pain, is suitable in surgical operation, is especially suitable for
The bonding of soft tissue.
Detailed description of the invention
Embodiment 1
The soft tissue binding agent with reducing swelling and alleviating pain effect of the present embodiment, comprises following weight
Part component: polyvinyl pyrrolidone 55 parts, 3 parts of agar, mupirocin 5 parts, neutrality
Lipase 3 parts, sweet potato starch 5 parts, ethyl acetate 3 parts, Tripolyglycerol monostearates 3
Part, dittany corium farinosum 5 parts, Radix Sangusorbae powder 11 parts, tricalcium phosphate 5 parts, zinc oxide 3 parts.
Embodiment 2
The soft tissue binding agent with reducing swelling and alleviating pain effect of the present embodiment, comprises following weight
Part component: polyvinyl pyrrolidone 65 parts, 8 parts of agar, mupirocin 11 parts, neutrality
Lipase 7 parts, sweet potato starch 10 parts, ethyl acetate 8 parts, Tripolyglycerol monostearates
5 parts, dittany corium farinosum 15 parts, Radix Sangusorbae powder 14 parts, tricalcium phosphate 9 parts, zinc oxide 5 parts,
Sodium carboxymethyl cellulose 10 parts.
Embodiment 3
The soft tissue binding agent with reducing swelling and alleviating pain effect of the present embodiment, comprises following weight
Part component: polyvinyl pyrrolidone 55 parts, 3 parts of agar, mupirocin 5 parts, neutrality
Lipase 3 parts, sweet potato starch 5 parts, ethyl acetate 3 parts, Tripolyglycerol monostearates 3
Part, dittany corium farinosum 5 parts, Radix Sangusorbae powder 11 parts, tricalcium phosphate 5 parts, zinc oxide 3 parts, carboxylic
Sodium carboxymethylcellulose pyce 5 parts, sodium alginate 15 parts.
Embodiment 4
The soft tissue binding agent with reducing swelling and alleviating pain effect of the present embodiment, comprises following weight
Part component: polyvinyl pyrrolidone 65 parts, 8 parts of agar, mupirocin 11 parts, neutrality
Lipase 7 parts, sweet potato starch 10 parts, ethyl acetate 8 parts, Tripolyglycerol monostearates
5 parts, dittany corium farinosum 15 parts, Radix Sangusorbae powder 14 parts, tricalcium phosphate 9 parts, zinc oxide 5 parts,
Sodium carboxymethyl cellulose 10 parts, sodium alginate 20 parts, cellulose 14 parts.
The above, be only presently preferred embodiments of the present invention, not makees the present invention any
Pro forma restriction, although the present invention is disclosed above with preferred embodiment, but and is not used to
Limiting the present invention, any those skilled in the art, without departing from technical solution of the present invention
In the range of, when the technology contents of available the disclosure above makes a little change or is modified to equivalent change
The Equivalent embodiments changed, as long as being the content without departing from technical solution of the present invention, according to the present invention
Technical spirit any simple modification, equivalent variations and modification that above example is made, all
Still fall within the range of technical solution of the present invention.
Claims (4)
1. a soft tissue binding agent with reducing swelling and alleviating pain effect, it is characterised in that comprise
Following parts by weight of component: polyvinyl pyrrolidone 55-65 part, agar 3-8 part, not sieve
Star 5-11 part, neutral lipase 3-7 part, sweet potato starch 5-10 part, ethyl acetate 3-8 part,
Tripolyglycerol monostearates 3-5 part, dittany corium farinosum 5-15 part, Radix Sangusorbae powder 11-14 part,
Tricalcium phosphate 5-9 part, zinc oxide 3-5 part.
The soft tissue bonding with reducing swelling and alleviating pain effect the most according to claim 1
Agent, it is characterised in that: it also comprises sodium carboxymethyl cellulose 5-10 part.
The soft tissue bonding with reducing swelling and alleviating pain effect the most according to claim 2
Agent, it is characterised in that: it also comprises sodium alginate 15-20 part.
The soft tissue binding agent with reducing swelling and alleviating pain effect the most according to claim 3,
It is characterized in that: it also comprises cellulose 11-14 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610427515.9A CN105999388A (en) | 2016-06-15 | 2016-06-15 | Soft tissue adhesive with effects of relieving swelling and pain |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610427515.9A CN105999388A (en) | 2016-06-15 | 2016-06-15 | Soft tissue adhesive with effects of relieving swelling and pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105999388A true CN105999388A (en) | 2016-10-12 |
Family
ID=57088480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610427515.9A Withdrawn CN105999388A (en) | 2016-06-15 | 2016-06-15 | Soft tissue adhesive with effects of relieving swelling and pain |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105999388A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101980729A (en) * | 2007-12-17 | 2011-02-23 | 新特斯有限责任公司 | Crosslinked hydrogels |
| CN104399113A (en) * | 2014-11-25 | 2015-03-11 | 苏州市贝克生物科技有限公司 | Adhesive for soft tissues and preparation method of adhesive |
-
2016
- 2016-06-15 CN CN201610427515.9A patent/CN105999388A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101980729A (en) * | 2007-12-17 | 2011-02-23 | 新特斯有限责任公司 | Crosslinked hydrogels |
| CN104399113A (en) * | 2014-11-25 | 2015-03-11 | 苏州市贝克生物科技有限公司 | Adhesive for soft tissues and preparation method of adhesive |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161012 |