CN105935452A - Skin adhesive with anti-inflammation and sterilization efficacy - Google Patents

Skin adhesive with anti-inflammation and sterilization efficacy Download PDF

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Publication number
CN105935452A
CN105935452A CN201610398689.7A CN201610398689A CN105935452A CN 105935452 A CN105935452 A CN 105935452A CN 201610398689 A CN201610398689 A CN 201610398689A CN 105935452 A CN105935452 A CN 105935452A
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CN
China
Prior art keywords
parts
binding agent
antiinflammatory
inflammation
skin adhesive
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Withdrawn
Application number
CN201610398689.7A
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Chinese (zh)
Inventor
董芬芳
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Huzhou Guoxin Materials Co Ltd
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Huzhou Guoxin Materials Co Ltd
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Priority to CN201610398689.7A priority Critical patent/CN105935452A/en
Publication of CN105935452A publication Critical patent/CN105935452A/en
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a skin adhesive with anti-inflammation and sterilization efficacy. The skin adhesive comprises the following components by weight: 50-70 parts of polyphosphazene, 5-10 parts of sodium dodecyl sulfate, 3-7 parts of azone, 15-25 parts of sweet potato starch, 5-9 parts of linoleic acid, 3-8 parts of metronidazole, 2-8 parts of squalane, 5-10 parts of sodium carboxymethylcellulose, 10-20 parts of angelica dahurica powder, 2-8 parts of titanium dioxide, 2-5 parts of glutamic acid, and 3-7 parts of aloin. The skin adhesive with anti-inflammation and sterilization efficacy provided by the invention has the characteristics of low irritation, high bonding strength, good bonding film toughness, and no side effect, also has anti-inflammation and sterilization efficacy, and can be widely used in clinical treatment.

Description

A kind of skin binding agent with antiinflammatory biocidal efficacies
Technical field
The invention belongs to biomedical materials field, be specifically related to one and there is antiinflammatory biocidal efficacies Skin binding agent.
Background technology
Biomaterial is for tissue and the diagnosis of organ, repairs or promote the one of its function Class High-tech Material, is i.e. used for replacing, repairing living tissue natural or artificial material, its effect Medicine is irreplaceable.Biomaterial can perform, promote or replace because disease, damage etc. lose Certain function, and rejected region can not be recovered.Since the later stage nineties, world's biology material Material Science and Technology develops rapidly, even if under the overall situation that current global economy is low, biological Material still remains annual 13% rapid growth, has fully demonstrated its powerful vitality with wide Wealthy development prospect.The regeneration of modern medicine forward and rebuild impaired tissue and organ, Recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment to develop.Traditional nothing The conventional materials such as the medical metal of life, macromolecule, bioceramic can not meet medical development Requirement, biomedical material scientific and engineering is faced with new opportunities and challenges.Future, raw Medicine may well will be caught up with in the market share of thing medical material.Therefore, bio-medical is strengthened The clinical application research of material and popularization and application, give priority to grinding of China's bio-medical material Study carefully, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice, Country currently has been achieved for important breakthrough progress in terms of biomaterial scientific basic research, walks In world's rank of advanced units, but industrialization level waits to improve, and industry size is little, development is relative Delayed, it is not met by being actually needed of Medicare health care.In national policy, economic big Under power is supported, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen autonomous innovation Ability, solve further to rely on the situation of import, add large outlet dynamics, it is achieved cross over simultaneously Development, expands Chinese biological material product power of influence in the world.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial bag Include metal material (such as alkali metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyl Base apatite etc.) and organic material three major types.Organic material is mainly polymeric set compound material Material, macromolecular material generally by material properties be divided into synthesis macromolecular material (polyurethane, polyester, Polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber Deng), natural macromolecular material (such as collagen, fibroin, cellulose, chitosan etc.)；According to The purposes of material, these materials can be divided into again biologically inert (bioinert), biological activity Or biodegradation (biodegradable) material, high molecular polymer (bioactive) In, can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again life Thing absorbability and biological nonabsorable.According to after material and contacting blood to blood constituent, The state that affects of performance is then divided into blood compatible polymer and blood incompatibility.According to material To the affinity of body cell with report situations, biocompatibility and bio-incompatibility can be divided into Polymer etc..
Adhesive of medical just belongs to the one in biodegradation material, and adhesive of medical is mainly used in The various operations of surgery such as various traumatic wounds, cosmetic surgery, family planning, it is to human-body biological Tissue has quick-binding, promotes the effects such as wound healing, can partly replace wound suture.Doctor With a long history with the use of binding agent, clinic has highly important effect, soft group can be divided into Knit with binding agent, dental binding agent, bone cement and skin binding agent etc..Wherein, skin It is a kind of medical adhesive with binding agent, for binding skin wound.Along with the progress of medical science, clinical On to surgical technic and auxiliary material result requirement more and more higher.The theory of modern medicine is intended to Reduce the misery of patient to greatest extent, allow patients ' recovery prestissimo, and in maximum journey While degree ground recovers function, it is desirable to outward appearance also can ideally be recovered.Therefore clinical demand is not Disconnected increase has promoted development and adhering technique that adhesive of medical studies in clinical application.Simultaneously The skin binding agent that medical circle is conventional at present, comes with some shortcomings, as relatively low in viscosity, bonding Insufficient strength, function singleness etc..Accordingly, it would be desirable to develop a kind of bonding strength height and have anti- The skin binding agent of scorching biocidal efficacies.
Summary of the invention
It is an object of the invention to provide a kind of skin binding agent with antiinflammatory biocidal efficacies.
To achieve these goals, the invention provides a kind of skin with antiinflammatory biocidal efficacies With binding agent, comprise following parts by weight of component: poly phosphazene 50-70 part, sodium lauryl sulphate 5-10 part, azone 3-7 part, sweet potato starch 15-25 part, linoleic acid 5-9 part, metronidazole 3-8 part, squalane 2-8 part, sodium carboxymethyl cellulose 5-10 part, Radix Angelicae Dahuricae powder 10-20 part, Titanium dioxide 2-8 part, glutamic acid 2-5 part, aloin 3-7 part.
It also comprises Tripolyglycerol monostearates 3-5 part.
It also comprises xanthan gum 4-7 part.
It also comprises sodium alginate 10-15 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in container, in room Under temperature after ultrasonic 1-6h, it is then heated to 40-100 DEG C, stirs 1-3h, then the place that carries out disinfection Manage.
Beneficial effect: a kind of skin binding agent with antiinflammatory biocidal efficacies of the present invention stimulates Property low, adhesion strength is high, adhesive film good toughness, has no side effect, and also has the merit of antiinflammatory sterilization Effect, can be widely used in clinical treatment.
Detailed description of the invention
Embodiment 1
The skin binding agent with antiinflammatory biocidal efficacies of the present embodiment, comprises following weight portion Component: poly phosphazene 50 parts, sodium lauryl sulphate 5 parts, azone 3 parts, sweet potato starch 15 Part, linoleic acid 5 parts, metronidazole 3 parts, squalane 2 parts, sodium carboxymethyl cellulose 5 parts, 10 parts of Radix Angelicae Dahuricae powder, titanium dioxide 2 parts, 2 parts of glutamic acid, aloin 3 parts.
Embodiment 2
The skin binding agent with antiinflammatory biocidal efficacies of the present embodiment, comprises following weight portion Component: poly phosphazene 70 parts, sodium lauryl sulphate 10 parts, azone 7 parts, sweet potato starch 25 parts, linoleic acid 9 parts, metronidazole 8 parts, squalane 8 parts, sodium carboxymethyl cellulose 10 Part, 20 parts of Radix Angelicae Dahuricae powder, titanium dioxide 8 parts, 5 parts of glutamic acid, aloin 7 parts, trimerization Glyceryl monostearate 5 parts.
Embodiment 3
The skin binding agent with antiinflammatory biocidal efficacies of the present embodiment, comprises following weight portion Component: poly phosphazene 50 parts, sodium lauryl sulphate 5 parts, azone 3 parts, sweet potato starch 15 Part, linoleic acid 5 parts, metronidazole 3 parts, squalane 2 parts, sodium carboxymethyl cellulose 5 parts, 10 parts of Radix Angelicae Dahuricae powder, titanium dioxide 2 parts, 2 parts of glutamic acid, aloin 3 parts, three polyglycereol Monostearate 3 parts, xanthan gum 4 parts.
Embodiment 4
The skin binding agent with antiinflammatory biocidal efficacies of the present embodiment, comprises following weight portion Component: poly phosphazene 70 parts, sodium lauryl sulphate 10 parts, azone 7 parts, sweet potato starch 25 parts, linoleic acid 9 parts, metronidazole 8 parts, squalane 8 parts, sodium carboxymethyl cellulose 10 Part, 20 parts of Radix Angelicae Dahuricae powder, titanium dioxide 8 parts, 5 parts of glutamic acid, aloin 7 parts, trimerization Glyceryl monostearate 5 parts, xanthan gum 7 parts, sodium alginate 15 parts.
The above, be only presently preferred embodiments of the present invention, not makees the present invention any Pro forma restriction, although the present invention is disclosed above with preferred embodiment, but and is not used to Limiting the present invention, any those skilled in the art, without departing from technical solution of the present invention In the range of, when the technology contents of available the disclosure above makes a little change or is modified to equivalent change The Equivalent embodiments changed, as long as being the content without departing from technical solution of the present invention, according to the present invention Technical spirit any simple modification, equivalent variations and modification that above example is made, all Still fall within the range of technical solution of the present invention.

Claims (4)

1. a skin binding agent with antiinflammatory biocidal efficacies, it is characterised in that comprise with Lower parts by weight of component: poly phosphazene 50-70 part, sodium lauryl sulphate 5-10 part, azone 3-7 Part, sweet potato starch 15-25 part, linoleic acid 5-9 part, metronidazole 3-8 part, squalane 2-8 Part, sodium carboxymethyl cellulose 5-10 part, Radix Angelicae Dahuricae powder 10-20 part, titanium dioxide 2-8 part, Glutamic acid 2-5 part, aloin 3-7 part.
The skin binding agent with antiinflammatory biocidal efficacies the most according to claim 1, It is characterized in that: it also comprises Tripolyglycerol monostearates 3-5 part.
The skin binding agent with antiinflammatory biocidal efficacies the most according to claim 2, It is characterized in that: it also comprises xanthan gum 4-7 part.
The skin binding agent with antiinflammatory biocidal efficacies the most according to claim 3, It is characterized in that: it also comprises sodium alginate 10-15 part.
CN201610398689.7A 2016-06-06 2016-06-06 Skin adhesive with anti-inflammation and sterilization efficacy Withdrawn CN105935452A (en)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06304239A (en) * 1993-04-27 1994-11-01 Nichiban Co Ltd Adhesive tape for skin therapy
CN101909667A (en) * 2008-01-10 2010-12-08 爱乐康株式会社 Pressure-sensitive adhesive agent for skin, pressure-sensitive adhesive sheet for skin and face plate of ostomy appliance
CN102327651A (en) * 2010-07-12 2012-01-25 北京迈迪顶峰医疗科技有限公司 Anti-adhesion membrane
CN104874008A (en) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 Method for preparing medical bio-antimicrobial dressing
CN104906628A (en) * 2015-05-22 2015-09-16 苏州市贝克生物科技有限公司 Method for preparing medical antisepsis and anti-inflammation sponge

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06304239A (en) * 1993-04-27 1994-11-01 Nichiban Co Ltd Adhesive tape for skin therapy
CN101909667A (en) * 2008-01-10 2010-12-08 爱乐康株式会社 Pressure-sensitive adhesive agent for skin, pressure-sensitive adhesive sheet for skin and face plate of ostomy appliance
CN102327651A (en) * 2010-07-12 2012-01-25 北京迈迪顶峰医疗科技有限公司 Anti-adhesion membrane
CN104874008A (en) * 2015-05-22 2015-09-02 苏州市贝克生物科技有限公司 Method for preparing medical bio-antimicrobial dressing
CN104906628A (en) * 2015-05-22 2015-09-16 苏州市贝克生物科技有限公司 Method for preparing medical antisepsis and anti-inflammation sponge

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
苑振亭 等主编: "《临证中药500味手册（配彩图）》", 29 February 2016, 金盾出版社 *
赵克键 主编: "《现代药学名词手册》", 31 October 2004, 中国医药科技出版社 *

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