CN106039387A - Medical absorbable suture - Google Patents
Medical absorbable suture Download PDFInfo
- Publication number
- CN106039387A CN106039387A CN201610430005.7A CN201610430005A CN106039387A CN 106039387 A CN106039387 A CN 106039387A CN 201610430005 A CN201610430005 A CN 201610430005A CN 106039387 A CN106039387 A CN 106039387A
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- absorbable suture
- powder
- suture
- acid
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
Abstract
The invention discloses a medical absorbable suture, comprising the following components according to parts by weight: 60-70 parts of polylactic acid, 4-16 parts of tilapia scale collagen, 5-11 parts of laurocapram, 4-7 parts of a citrate, 5-10 parts of glyceryl monostearate, 5-9 parts of linoleic acid, 8-10 parts of tea tree essential oil, 10-15 parts of Resina Draconis powder, 10-18 parts of borneol, 10-20 parts of motherwort powder, 3-7 parts of aloin, 5-10 parts of sodium carboxymethyl cellulose and 15-20 parts of sweet potato starch. The medical absorbable suture has good blood compatibility and tissue compatibility, causes no inflammation response, causes no exclusion and adverse reaction in the human body, has high mechanical properties and is degradable and absorbable, and a gradation product of the suture is safe and nontoxic to the human body and is free of irritation.
Description
Technical field
The invention belongs to biomedical materials field, be specifically related to a kind of Surgical Absorbable Suture.
Background technology
Biomaterial is for tissue and the diagnosis of organ, the class High-tech Material repairing or promoting its function,
I.e. being used for replacing, repairing living tissue natural or artificial material, its drugs with function is irreplaceable.Biomaterial can perform, promote
Or replace certain function lost because of disease, damage etc., and rejected region can not be recovered.Since the later stage nineties, the world is raw
Thing material science and technology develop rapidly, even if under the overall situation that current global economy is low, biomaterial still remains
Annual 13% rapid growth, has fully demonstrated its powerful vitality and vast potential for future development.Modern medicine forward regeneration and
Rebuild impaired tissue and organ, recover and promote the directions such as human body physiological function, personalization and minimally-invasive treatment and develop.
The conventional materials such as traditional abiotic medical metal, macromolecule, bioceramic can not meet the requirement of medical development, biological
Medical material scientific and engineering is faced with new opportunities and challenges.In future, the market share of bio-medical material may well
Medicine will be caught up with.Therefore, strengthen clinical application research and the popularization and application of bio-medical material, give priority to China's bio-medical
The research of material, develop, produce, the integrated system combined closely of marketing is the task of top priority.It practice, country is current at biology
Fundamentals of Material Science research aspect has been achieved for important breakthrough progress, walks in world's rank of advanced units, but industrialization level is still
Waiting to improve, industry size is little, development relatively lags behind, and is not met by being actually needed of Medicare health care.National policy,
Under economic support energetically, the industrialized development of China's biomaterial will speed-raising.Enterprise should strengthen the ability of autonomous innovation, enters one
Step solves to rely on the situation of import, adds large outlet dynamics, it is achieved spanning development simultaneously, expands Chinese biological material product in the world
On power of influence.
Biomaterial is widely used, and kind is a lot, and its sorting technique is the most a lot.Biomaterial includes that metal material is (such as alkali
Metal and alloy thereof etc.), inorganic material (bioactive ceramics, hydroxyapatite etc.) and organic material three major types.Organic material
In mainly polymeric set laminate material, macromolecular material is generally divided into synthesis macromolecular material (polyurethane, poly-by material properties
Ester, polylactic acid, polyglycolic acid, PLGA and other medical synthetic plastic and rubber etc.), natural macromolecular material
(such as collagen, fibroin, cellulose, chitosan etc.)；According to the purposes of material, these materials can be divided into again biologically inert
(bioinert), biological activity (bioactive) or biodegradation (biodegradable) material, in high molecular polymer, root
Can be by organism metabolism and absorption according to catabolite, degradation-type macromolecule can be divided into again Bioabsorbable and biological nonabsorable
Property.Blood compatible polymer and blood then it is divided into according to the state that affects on blood constituent, performance after material and contacting blood
Incompatibility.To the affinity of body cell and report situations according to material, biocompatibility and bio-incompatibility can be divided into
Polymer etc..Wherein, suture just belongs to the one in biodegradation material, for wound healing, tissue ligation and group
Knitting fixing, the initial stage healing to wound plays a very important role.Generally can be divided into absorbable thread and the big class of nonabsorable line two, no
Absorbable suture is the most non-degradable, if do not taken out, stays in the tissue as health foreign body, is easier to cause tissue infection；
Absorbable suture is degraded by acid, alkali or enzyme effect in bodily tissue, degradation speed depend on the temperature of tissue, pH value and
Liquid environment around stitching thread, degraded afterproduct is converted into metabolite and the Excreta of human body, nontoxic.But doctor
The absorbable suture that educational circles commonly uses mostly is catgut, polymer chemistry synthetic thread, there is poor biocompatibility, Yi Yin during use
Send out tissue immunity reaction, absorb the problems such as insufficient and bad mechanical property.The Medical absorbable that medical circle is conventional the most at present
Stitching thread, although ratio is more prominent in terms of absorbability, but effect is the most single, therefore use on be restricted, need into
One step is improved.Accordingly, it would be desirable to develop the Surgical Absorbable Suture that a kind of mechanical performance is high, tissue reaction is low.
Summary of the invention
It is an object of the invention to provide a kind of Surgical Absorbable Suture.
To achieve these goals, the invention provides a kind of Surgical Absorbable Suture, including in parts by weight
Following component: polylactic acid 60-70 part, Rofe scale collagen 4-16 part, laurocapram 5-11 part, citrate 4-7 part, hard
Fat acid list glyceride 5-10 part, linoleic acid 5-9 part, tea tree ethereal oil 8-10 part, Sanguis Draxonis powder 10-15 part, Borneolum Syntheticum 10-18 part, Herba Leonuri
Grass meal 10-20 part, aloin 3-7 part, sodium carboxymethyl cellulose 5-10 part, sweet potato starch 15-20 part.
It also comprises linoleic acid 5-9 part.
It also comprises polysorbate 4-12 part.
It also comprises Fructus Gleditsia powder 5-8 part.
Its preparation method is: weigh each raw material by weight, adds raw materials in reactor, the most ultrasonic 1-6h
After, it is then heated to 50-90 DEG C, stirs 1-3h, obtain blend；Blend is extruded, water-cooled, air-dry, pelletizing, obtain mother
Grain；Master batch is heated to 120-150 DEG C, by spinneret spray webbing, makes as-spun fibre, more stretched sizing, obtains finished product fine
Dimension, sterilization packaging, obtain Surgical Absorbable Suture.
Beneficial effect: a kind of Surgical Absorbable Suture of the present invention, has good blood compatibility and tissue compatible
Property, NIP reacts, and without rejection and untoward reaction in human body, mechanical performance is high, and degraded and absorbed and catabolite are to human body
Safety non-toxic, non-stimulated.
Detailed description of the invention
Embodiment 1
The Surgical Absorbable Suture of the present embodiment, the following component including in parts by weight: polylactic acid 60 parts, sieve
Non-scale collagen 4 parts, laurocapram 5 parts, citrate 4 parts, stearic acid list glyceride 5 parts, linoleic acid 5 parts, tea tree ethereal oil 8
Part, Sanguis Draxonis powder 10 parts, Borneolum Syntheticum 10 parts, motherwort powder 10 parts, aloin 3 parts, sodium carboxymethyl cellulose 5 parts, sweet potato starch 15 parts.
Embodiment 2
The Surgical Absorbable Suture of the present embodiment, the following component including in parts by weight: polylactic acid 70 parts, sieve
Non-scale collagen 16 parts, laurocapram 11 parts, citrate 7 parts, stearic acid list glyceride 10 parts, linoleic acid 9 parts, Camellia sinensis essence
Oil 10 parts, Sanguis Draxonis powder 15 parts, Borneolum Syntheticum 18 parts, motherwort powder 20 parts, aloin 7 parts, sodium carboxymethyl cellulose 10 parts, sweet potato starch
20 parts, linoleic acid 9 parts.
Embodiment 3
The Surgical Absorbable Suture of the present embodiment, the following component including in parts by weight: polylactic acid 60 parts, sieve
Non-scale collagen 4 parts, laurocapram 5 parts, citrate 4 parts, stearic acid list glyceride 5 parts, linoleic acid 5 parts, tea tree ethereal oil 8
Part, Sanguis Draxonis powder 10 parts, Borneolum Syntheticum 10 parts, motherwort powder 10 parts, aloin 3 parts, sodium carboxymethyl cellulose 5 parts, sweet potato starch 15 parts,
Linoleic acid 5 parts, polysorbate 4 parts.
Embodiment 4
The Surgical Absorbable Suture of the present embodiment, the following component including in parts by weight: polylactic acid 70 parts, sieve
Non-scale collagen 16 parts, laurocapram 11 parts, citrate 7 parts, stearic acid list glyceride 10 parts, linoleic acid 9 parts, Camellia sinensis essence
Oil 10 parts, Sanguis Draxonis powder 15 parts, Borneolum Syntheticum 18 parts, motherwort powder 20 parts, aloin 7 parts, sodium carboxymethyl cellulose 10 parts, sweet potato starch
20 parts, linoleic acid 9 parts, polysorbate 12 parts, 8 parts of Fructus Gleditsia powder.
The above, be only presently preferred embodiments of the present invention, and the present invention not makees any pro forma restriction, though
So the present invention is disclosed above with preferred embodiment, but is not limited to the present invention, any technology people being familiar with this specialty
Member, in the range of without departing from technical solution of the present invention, when the technology contents of available the disclosure above makes a little change or modification
For the Equivalent embodiments of equivalent variations, as long as being the content without departing from technical solution of the present invention, the technical spirit of the foundation present invention
Any simple modification, equivalent variations and the modification being made above example, all still falls within the range of technical solution of the present invention.
Claims (4)
1. a Surgical Absorbable Suture, it is characterised in that include following component in parts by weight: polylactic acid 60-70
Part, Rofe scale collagen 4-16 part, laurocapram 5-11 part, citrate 4-7 part, stearic acid list glyceride 5-10 part, Asia
Oleic acid 5-9 part, tea tree ethereal oil 8-10 part, Sanguis Draxonis powder 10-15 part, Borneolum Syntheticum 10-18 part, motherwort powder 10-20 part, aloin 3-7
Part, sodium carboxymethyl cellulose 5-10 part, sweet potato starch 15-20 part.
Surgical Absorbable Suture the most according to claim 1, it is characterised in that: it also comprises linoleic acid 5-9 part.
Surgical Absorbable Suture the most according to claim 2, it is characterised in that: it also comprises polysorbate 4-12
Part.
Surgical Absorbable Suture the most according to claim 3, it is characterised in that: it also comprises Fructus Gleditsia powder 5-8 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610430005.7A CN106039387A (en) | 2016-06-16 | 2016-06-16 | Medical absorbable suture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610430005.7A CN106039387A (en) | 2016-06-16 | 2016-06-16 | Medical absorbable suture |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106039387A true CN106039387A (en) | 2016-10-26 |
Family
ID=57167509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610430005.7A Withdrawn CN106039387A (en) | 2016-06-16 | 2016-06-16 | Medical absorbable suture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106039387A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113550021A (en) * | 2021-08-10 | 2021-10-26 | 苏州大学 | Antibacterial nanofiber and preparation method thereof |
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|---|---|---|---|---|
| EP1660630A2 (en) * | 2003-07-24 | 2006-05-31 | Materials Evolution and Development Usa, Inc. | Nucleic acid biomaterials and methods of formation and use |
| CN104383592A (en) * | 2014-11-25 | 2015-03-04 | 苏州市贝克生物科技有限公司 | Medical absorbable polyvinyl alcohol suture line and preparation method thereof |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105056295A (en) * | 2015-08-11 | 2015-11-18 | 安徽省康宁医疗用品有限公司 | Anti-inflammatory, anti-bacterial and absorbable medical suture and preparation method thereof |
| CN105079868A (en) * | 2015-08-11 | 2015-11-25 | 安徽省康宁医疗用品有限公司 | Good-compatibility and absorbable medical suture line and production method thereof |
-
2016
- 2016-06-16 CN CN201610430005.7A patent/CN106039387A/en not_active Withdrawn
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| EP1660630A2 (en) * | 2003-07-24 | 2006-05-31 | Materials Evolution and Development Usa, Inc. | Nucleic acid biomaterials and methods of formation and use |
| CN104383592A (en) * | 2014-11-25 | 2015-03-04 | 苏州市贝克生物科技有限公司 | Medical absorbable polyvinyl alcohol suture line and preparation method thereof |
| CN104474586A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyglycolic acid medical absorbable suture and preparation method thereof |
| CN105056295A (en) * | 2015-08-11 | 2015-11-18 | 安徽省康宁医疗用品有限公司 | Anti-inflammatory, anti-bacterial and absorbable medical suture and preparation method thereof |
| CN105079868A (en) * | 2015-08-11 | 2015-11-25 | 安徽省康宁医疗用品有限公司 | Good-compatibility and absorbable medical suture line and production method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113550021A (en) * | 2021-08-10 | 2021-10-26 | 苏州大学 | Antibacterial nanofiber and preparation method thereof |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20161026 |
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| WW01 | Invention patent application withdrawn after publication |