CN109248334A - A kind of surgical sewing thread antibacterial agent and preparation method thereof - Google Patents
A kind of surgical sewing thread antibacterial agent and preparation method thereof Download PDFInfo
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- CN109248334A CN109248334A CN201811006002.6A CN201811006002A CN109248334A CN 109248334 A CN109248334 A CN 109248334A CN 201811006002 A CN201811006002 A CN 201811006002A CN 109248334 A CN109248334 A CN 109248334A
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- antibacterial agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of preparation methods of surgical sewing thread antibacterial agent, include the following steps: the preparation of (one) chloro-lactic acid silver class compound, (2) 5- (4- chlorobutyl) glycolylurea modification of chitosan, the doping of (three) silver ion.Antibacterial agent is used the invention also discloses the surgical sewing thread being prepared using the preparation method and uses antibacterial agent as the surgical sewing thread of antibiosis additive using the surgical sewing thread.Surgical sewing thread disclosed by the invention antibacterial agent prepares cheap, and antibacterial effect is significant, and good with operation suture thread compatibility, anti-microbial property stability is more preferable, uses safety and environmental protection.
Description
Technical field
The invention belongs to surgical operation equipment technical fields, are related to a kind of common surgical procedures suture inorganic agent,
Specifically, being related to a kind of surgical sewing thread antibacterial agent and preparation method thereof.
Background technique
In recent years, with the increasing of life and work pressure, the deterioration of ecological environment, various diseases hover in people's body
Side, these diseases have brought great pain, their treatment is the problem of people have to face.Some are more tight
The disease of weight needs operative treatment, and in surgical procedure, a kind of essential equipment is operation suture thread.Operation stitching
Line is in surgical operation or in wound processing, for pricking hemostasis and Suture hemostasis and organizing the special of suture
Line can be generally divided into absorbable thread and nonabsorable line.Although these operation suture threads go out by high temperature in application process
Bacterium processing, but also only bacterium original on suture is killed, and suture itself does not play bactericidal effect, when
After being infected by bacterial at wound suture, bacterium can breed under suitable conditions bursts purulence so as to cause wound, or generates tighter
The consequence of weight.Therefore, it is particularly important to seek more efficiently antibiotic and sterilizing method.
Operation suture thread is handled using antibacterial agent to improve the effective measures of its antibiotic and sterilizing performance.It is existing anti-
Microbial inoculum includes inorganic antiseptic and organic antibacterial agent two types, and inorganic antiseptic is not easy to disperse since biocompatibility is bad
Uniformly, exosmose is easy to appear after being added in operation suture thread in use, so that anti-microbial property substantially reduces.It is existing
There is the organic antibacterial agent in technology to be more toxic, while playing antibiotic and sterilizing effect, is brought to the health of patient
Other injuries.
Therefore, it in surgical technic field, needs a kind of to use with excellent anti-microbial property, using safe operation suture thread
Antibacterial agent.
Summary of the invention
In order to overcome the defects of the prior art, the present invention is intended to provide a kind of prepare cheap, antibacterial effect is significant,
Good with operation suture thread compatibility, anti-microbial property stability is more preferable, using the surgical sewing thread antibacterial agent of safety and environmental protection,
Preparation method is provided simultaneously.
The present invention is realized by the following scheme: a kind of preparation method of surgical sewing thread antibacterial agent, including it is as follows
Step:
The preparation of I chloro-lactic acid silver class compound: actol, epoxychloropropane are added in tetrahydrofuran, stir 15-
20 minutes, then basic catalyst is added thereto, it is stirred to react 8-10 hours, is cooled to room temperature at 95-105 DEG C, filter, after
Revolving removes solvent, obtains chloro-lactic acid silver class compound；
II 5- (4- chlorobutyl) glycolylurea modification of chitosan: chitosan, 5- (4- chlorobutyl) glycolylurea are dissolved in organic solvent,
And catalyst is added thereto, it is stirred to react at 40-60 DEG C 6-8 hours, is cooled to room temperature after reaction, revolving, which removes, to be had
Solvent, then water is added thereto, it filters, is finally placed at 90-100 DEG C of vacuum oven and dries 10-15 hours, obtain 5- (4-
Chlorobutyl) glycolylurea modification of chitosan；
III silver ion doping: by 5- (4- chlorobutyl) the glycolylurea modification of chitosan being prepared by step II, by step
The rapid I chloro-lactic acid silver class compound that is prepared, tetrabutylammonium bromide are added to the water, and are stirred to react 10- at 60-80 DEG C
It is 12 hours, rear to filter, it is washed with water 3-5 times, obtains surgical sewing thread antibacterial agent.
Preferably, the mass ratio of actol described in step I, epoxychloropropane, tetrahydrofuran, basic catalyst is
2.13:1:(10-15):(0.4-0.6)。
Preferably, the basic catalyst is selected from one of sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide or several
Kind.
Preferably, the mass ratio (3- of chitosan described in step II, 5- (4- chlorobutyl) glycolylurea, organic solvent, catalyst
5):(0.5-1):(10-15):0.7。
Preferably, the organic solvent is selected from one or more of acetic acid, formic acid, benzoic acid.
Preferably, the catalyst in tetrabutylammonium bromide, 1- butyl -3- methyl imidazolium tetrafluoroborate at least
It is a kind of.
Preferably, 5- described in step III (4- chlorobutyl) glycolylurea modification of chitosan, chloro-lactic acid silver class compound, four fourths
Base ammonium bromide, water mass ratio be (3-5): (0.5-1): 0.7:(20-25).
Further, a kind of surgical sewing thread antibacterial agent, using above-mentioned surgical sewing thread antibacterial agent
Preparation method is prepared.
Further, a kind of surgical sewing thread uses antibacterial agent as at antibacterial using above-mentioned surgical sewing thread
Manage agent.
The beneficial effects of adopting the technical scheme are that
1) preparation method of surgical sewing thread antibacterial agent provided by the invention, simple process is easy to operate, to equipment
Dependence is not high, not harsh to reaction condition requirement, and raw material is easy to get, and preparation cost is cheap, is suitble to large-scale production.
2) surgical sewing thread antibacterial agent provided by the invention overcomes traditional surgery suture in the prior art
The generally existing biocompatibility of line antibacterial agent is bad, is not easy to be uniformly dispersed, and is using after being added in operation suture thread
Exosmose is easy to appear in journey, stability is poor, the big problem of toxic side effect, has and prepares cheap, preparation price
Cheap, antibacterial effect is significant, good with operation suture thread compatibility, and anti-microbial property stability is more preferable, uses more safety and environmental protection
Advantage.
3) surgical sewing thread antibacterial agent provided by the invention, combines glycolylurea, chitosan, silver ion, quaternary ammonium salt
Advantage, synergistic effect, so that anti-microbial property is excellent, and each structure and ingredient effectively prevent using with chemistry key connection
The loss of process improves anti-microbial property stability, avoids previous antibacterial agent to the selection unicity of sterilizing strain, to a variety of
Mushroom has sterilization antibacterial action.
4) surgical sewing thread antibacterial agent provided by the invention, silver ion introduce antibacterial by way of organic salt
In agent, on the one hand, be conducive to it and be uniformly dispersed, so that on the other hand performance performance stable homogeneous avoids Conventional nano
Silver antibacterial agent is easy to happen aggregation because particle is tiny in preparation, and oxidation reaction can occur in air and generate oxygen for particle exposure
The technical issues of changing silver, and declining anti-microbial property；And antibacterial agent synthetic material is safe and non-toxic, antibacterial agent good biocompatibility,
Good with operation suture thread substrate compatibility, biodegradable ability is good, and use is safe.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, and make features described above of the invention,
Purpose and advantage are more clear understandable, and the present invention will be further explained with reference to the examples below.Embodiment is only used for
It is bright the present invention rather than limit the scope of the invention.
Raw material described in the following embodiments of the present invention is from upper Haiquan sunrise foreign trade Co., Ltd.
Embodiment 1
A kind of preparation method of surgical sewing thread antibacterial agent, includes the following steps:
The preparation of I chloro-lactic acid silver class compound: actol 21.3g, epoxychloropropane 10g are added to tetrahydrofuran
It in 100g, stirs 15 minutes, then sodium carbonate 4g is added thereto, be stirred to react 8 hours, be cooled to room temperature at 95 DEG C, filter,
Solvent is evaporated off in back spin, obtains chloro-lactic acid silver class compound；
II 5- (4- chlorobutyl) glycolylurea modification of chitosan: chitosan 30g, 5- (4- chlorobutyl) glycolylurea 5g is dissolved in acetic acid
In 100g, and tetrabutylammonium bromide 7g is added thereto, is stirred to react at 40 DEG C 6 hours, is cooled to room temperature after reaction,
Revolving removes acetic acid, then water is added thereto, filters, is finally placed at 90 DEG C of vacuum oven and dries 10 hours, obtain 5- (4- chlorine
Butyl) glycolylurea modification of chitosan；
The doping of III silver ion: by 5- (4- chlorobutyl) the glycolylurea modification of chitosan 30g being prepared by step II, pass through
Chloro-lactic acid silver class compound 5g, the tetrabutylammonium bromide 7g that step I is prepared are added in water 200g, are stirred at 60 DEG C
Reaction 10 hours, it is rear to filter, it is washed with water 3 times, obtains surgical sewing thread antibacterial agent.
A kind of surgical sewing thread antibacterial agent, using the preparation method system of above-mentioned surgical sewing thread antibacterial agent
It is standby to obtain.
A kind of surgical sewing thread uses antibacterial agent as antibiosis additive using above-mentioned surgical sewing thread.
Embodiment 2
A kind of preparation method of surgical sewing thread antibacterial agent, includes the following steps:
The preparation of I chloro-lactic acid silver class compound: actol 21.3g, epoxychloropropane 10g are added to tetrahydrofuran
It in 115g, stirs 16 minutes, then potassium carbonate 4.5g is added thereto, be stirred to react 8.5 hours, be cooled to room temperature at 97 DEG C,
Filtering, back spin are evaporated off solvent, obtain chloro-lactic acid silver class compound；
II 5- (4- chlorobutyl) glycolylurea modification of chitosan: chitosan 35g, 5- (4- chlorobutyl) glycolylurea 6g is dissolved in formic acid
In 115g, and 1- butyl -3- methyl imidazolium tetrafluoroborate 7g is added thereto, is stirred to react at 45 DEG C 6.5 hours, is reacted
After be cooled to room temperature, revolving removes formic acid removal, then water is added thereto, filters, is finally placed at 93 DEG C of vacuum oven and dries
12 hours, obtain 5- (4- chlorobutyl) glycolylurea modification of chitosan；
The doping of III silver ion: by 5- (4- chlorobutyl) the glycolylurea modification of chitosan 35g being prepared by step II, pass through
Chloro-lactic acid silver class compound 6.5g, the tetrabutylammonium bromide 7g that step I is prepared are added in water 220g, are stirred at 65 DEG C
Reaction 10.5 hours is mixed, it is rear to filter, it is washed with water 4 times, obtains surgical sewing thread antibacterial agent.
A kind of surgical sewing thread antibacterial agent, using the preparation method system of above-mentioned surgical sewing thread antibacterial agent
It is standby to obtain.
A kind of surgical sewing thread uses antibacterial agent as antibiosis additive using above-mentioned surgical sewing thread.
Embodiment 3
A kind of preparation method of surgical sewing thread antibacterial agent, includes the following steps:
The preparation of I chloro-lactic acid silver class compound: actol 21.3g, epoxychloropropane 10g are added to tetrahydrofuran
It in 125g, stirs 18 minutes, then sodium hydroxide 5g is added thereto, be stirred to react 9 hours, be cooled to room temperature, mistake at 99 DEG C
Filter, back spin are evaporated off solvent, obtain chloro-lactic acid silver class compound；
II 5- (4- chlorobutyl) glycolylurea modification of chitosan: chitosan 40g, 5- (4- chlorobutyl) glycolylurea 7.5g is dissolved in benzene first
In sour 130g, and tetrabutylammonium bromide 7g is added thereto, is stirred to react at 50 DEG C 7 hours, is cooled to room after reaction
Temperature, revolving removes benzoic acid, then water is added thereto, filters, is finally placed at 95 DEG C of vacuum oven and dries 13 hours, obtain 5-
(4- chlorobutyl) glycolylurea modification of chitosan；
The doping of III silver ion: by 5- (4- chlorobutyl) the glycolylurea modification of chitosan 40g being prepared by step II, pass through
Chloro-lactic acid silver class compound 7.5g, the tetrabutylammonium bromide 7g that step I is prepared are added in water 230g, are stirred at 70 DEG C
Reaction 11 hours is mixed, it is rear to filter, it is washed with water 5 times, obtains surgical sewing thread antibacterial agent.
A kind of surgical sewing thread antibacterial agent, using the preparation method system of above-mentioned surgical sewing thread antibacterial agent
It is standby to obtain.
A kind of surgical sewing thread uses antibacterial agent as antibiosis additive using above-mentioned surgical sewing thread.
Embodiment 4
A kind of preparation method of surgical sewing thread antibacterial agent, includes the following steps:
The preparation of I chloro-lactic acid silver class compound: actol 21.3g, epoxychloropropane 10g are added to tetrahydrofuran
It in 145g, stirs 18 minutes, then basic catalyst 5.5g is added thereto, be stirred to react 9.5 hours, be cooled at 103 DEG C
Room temperature, filtering, back spin are evaporated off solvent, obtain chloro-lactic acid silver class compound；The basic catalyst is sodium carbonate, carbonic acid
The mixture that potassium, sodium hydroxide, potassium hydroxide 1:1:2:1 in mass ratio are mixed；
II 5- (4- chlorobutyl) glycolylurea modification of chitosan: chitosan 45g, 5- (4- chlorobutyl) glycolylurea 9g is dissolved in organic molten
In agent 145g, and catalyst 7g is added thereto, is stirred to react at 55 DEG C 7.5 hours, is cooled to room temperature after reaction, revolves
Organic solvent is evaporated off, then water is added thereto, filters, is finally placed at 98 DEG C of vacuum oven and dries 14.5 hours, obtain 5-
(4- chlorobutyl) glycolylurea modification of chitosan；The organic solvent is that acetic acid, formic acid, benzoic acid 2:3:5 in mass ratio are mixed
Mixture；The catalyst is tetrabutylammonium bromide, 1- butyl -3- methyl imidazolium tetrafluoroborate 3:5 in mass ratio mixing
Made of mixture；
The doping of III silver ion: by 5- (4- chlorobutyl) the glycolylurea modification of chitosan 45g being prepared by step II, pass through
Chloro-lactic acid silver class compound 9g, the tetrabutylammonium bromide 7g that step I is prepared are added in water 245g, are stirred at 76 DEG C
Reaction 11.5 hours, it is rear to filter, it is washed with water 4 times, obtains surgical sewing thread antibacterial agent.
A kind of surgical sewing thread antibacterial agent, using the preparation method system of above-mentioned surgical sewing thread antibacterial agent
It is standby to obtain.
A kind of surgical sewing thread uses antibacterial agent as antibiosis additive using above-mentioned surgical sewing thread.
Embodiment 5
A kind of preparation method of surgical sewing thread antibacterial agent, includes the following steps:
The preparation of I chloro-lactic acid silver class compound: actol 21.3g, epoxychloropropane 10g are added to tetrahydrofuran
It in 150g, stirs 20 minutes, then potassium hydroxide 6g is added thereto, be stirred to react 10 hours, be cooled to room temperature at 105 DEG C,
Filtering, back spin are evaporated off solvent, obtain chloro-lactic acid silver class compound；
II 5- (4- chlorobutyl) glycolylurea modification of chitosan: chitosan 50g, 5- (4- chlorobutyl) glycolylurea 10g is dissolved in acetic acid
In 150g, and tetrabutylammonium bromide 7g is added thereto, is stirred to react at 60 DEG C 8 hours, is cooled to room temperature after reaction,
Revolving removes organic solvent, then water is added thereto, filters, is finally placed at 100 DEG C of vacuum oven and dries 15 hours, obtain 5-
(4- chlorobutyl) glycolylurea modification of chitosan；
The doping of III silver ion: by 5- (4- chlorobutyl) the glycolylurea modification of chitosan 50g being prepared by step II, pass through
Chloro-lactic acid silver class compound 10g, the tetrabutylammonium bromide 7g that step I is prepared are added in water 250g, are stirred at 80 DEG C
Reaction 12 hours is mixed, it is rear to filter, it is washed with water 5 times, obtains surgical sewing thread antibacterial agent.
A kind of surgical sewing thread antibacterial agent, using the preparation method system of above-mentioned surgical sewing thread antibacterial agent
It is standby to obtain.
A kind of surgical sewing thread uses antibacterial agent as antibiosis additive using above-mentioned surgical sewing thread.
Comparative example
Common surgical procedures suture antibacterial agent, according to the preparation of Chinese invention patent CN 102726448B embodiment 1
Method is prepared.
The performance of embodiment 1-5 and comparative example the surgical sewing thread antibacterial agent being prepared is examined respectively
It surveys, test method and test result are shown in Table 1.
Table 1
Seen from table 1, the surgical sewing thread of preparation of the embodiment of the present invention has more excellent antibacterial with antibacterial agent
Property and biocompatibility.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its
Equivalent defines.
Claims (9)
1. a kind of preparation method of surgical sewing thread antibacterial agent, which comprises the steps of:
The preparation of I chloro-lactic acid silver class compound: actol, epoxychloropropane are added in tetrahydrofuran, and 15-20 points of stirring
Clock, then basic catalyst is added thereto, it is stirred to react 8-10 hours, is cooled to room temperature at 95-105 DEG C, filter, it is rear to rotate
Solvent is removed, chloro-lactic acid silver class compound is obtained；
II 5- (4- chlorobutyl) glycolylurea modification of chitosan: chitosan, 5- (4- chlorobutyl) glycolylurea are dissolved in organic solvent, and to
Catalyst is wherein added, is stirred to react at 40-60 DEG C 6-8 hours, is cooled to room temperature after reaction, revolving removes organic molten
Agent, then water is added thereto, it filters, is finally placed at 90-100 DEG C of vacuum oven and dries 10-15 hours, obtain 5- (4- neoprene
Base) glycolylurea modification of chitosan；
III silver ion doping: by 5- (4- chlorobutyl) the glycolylurea modification of chitosan being prepared by step II, by step I system
Standby obtained chloro-lactic acid silver class compound, tetrabutylammonium bromide are added to the water, and it is small to be stirred to react 10-12 at 60-80 DEG C
When, it is rear to filter, it is washed with water 3-5 times, obtains surgical sewing thread antibacterial agent.
2. the preparation method of surgical sewing thread antibacterial agent according to claim 1, which is characterized in that in step I
The actol, epoxychloropropane, tetrahydrofuran, the mass ratio of basic catalyst are 2.13:1:(10-15): (0.4-0.6).
3. the preparation method of surgical sewing thread antibacterial agent according to claim 1, which is characterized in that the alkalinity
Catalyst is selected from one or more of sodium carbonate, potassium carbonate, sodium hydroxide, potassium hydroxide.
4. the preparation method of surgical sewing thread antibacterial agent according to claim 1, which is characterized in that in step II
The chitosan, 5- (4- chlorobutyl) glycolylurea, organic solvent, catalyst mass ratio (3-5): (0.5-1): (10-15): 0.7.
5. the preparation method of surgical sewing thread antibacterial agent according to claim 1, which is characterized in that described organic
Solvent is selected from one or more of acetic acid, formic acid, benzoic acid.
6. the preparation method of surgical sewing thread antibacterial agent according to claim 1, which is characterized in that the catalysis
Agent is selected from least one of tetrabutylammonium bromide, 1- butyl -3- methyl imidazolium tetrafluoroborate.
7. the preparation method of surgical sewing thread antibacterial agent according to claim 1, which is characterized in that in step III
5- (4- chlorobutyl) the glycolylurea modification of chitosan, chloro-lactic acid silver class compound, tetrabutylammonium bromide, water mass ratio be
(3-5):(0.5-1):0.7:(20-25)。
What 8. a kind of preparation method using any one of claim 1-7 surgical sewing thread antibacterial agent was prepared
Surgical sewing thread antibacterial agent.
9. a kind of use antibacterial agent as the surgical operation suturing of antibiosis additive using surgical sewing thread described in claim 8
Line.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111334053A (en) * | 2020-04-24 | 2020-06-26 | 刘平弟 | Antibacterial material of nano-silver covalent grafting halogenated hydantoin-based chitosan and preparation method thereof |
| CN115418855A (en) * | 2022-06-16 | 2022-12-02 | 聚治(苏州)纳米科技有限公司 | Preparation method of novel polysaccharide antibacterial antiviral textile after-finishing agent |
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